{ "uniprot_canonical_ac": "O75912-1", "uniprot_ac": "O75912", "uniprot_id": "DGKI_HUMAN", "mass": { "chemical_mass": 116997.0, "monoisotopic_mass": 116997.0 }, "refseq": { "ac": "NP_001308637", "name": "diacylglycerol kinase iota isoform 2", "summary": "This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" }, "gene_names": [ { "name": "DGKI", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75912", "id": "O75912" }, { "name": "DGK-IOTA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637", "id": "NP_001308637" }, { "name": "DGKI", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637", "id": "NP_001308637" } ], "protein_names": [ { "name": "Diacylglycerol kinase iota", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75912" }, { "name": "2.7.1.107", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75912" }, { "name": "DAG kinase iota; diglyceride kinase iota", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637", "id": "NP_001308637" }, { "name": "DAG kinase iota", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75912" }, { "name": "DGK-iota", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75912" }, { "name": "diacylglycerol kinase iota isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637", "id": "NP_001308637" } ], "function": [ { "annotation": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:9830018, PubMed:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:9830018). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912#function" }, { "database": "UniProtKB", "id": "D3YWQ0", "url": "https://www.uniprot.org/uniprot/D3YWQ0#function" }, { "database": "PubMed", "id": "9830018", "url": "https://glygen.org/publication/PubMed/9830018" }, { "database": "PubMed", "id": "23949095", "url": "https://glygen.org/publication/PubMed/23949095" } ] }, { "annotation": "Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001308637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" }, { "database": "PubMed", "id": "36059514", "url": "https://glygen.org/publication/PubMed/36059514" } ] }, { "annotation": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001308637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" }, { "database": "PubMed", "id": "19065143", "url": "https://glygen.org/publication/PubMed/19065143" } ] }, { "annotation": "The DGKI methylation status identified 22% of poorly responding patients in the low-risk group Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001308637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" }, { "database": "PubMed", "id": "25233099", "url": "https://glygen.org/publication/PubMed/25233099" } ] }, { "annotation": "This gene is a member of the type IV diacylglycerol kinase subfamily. Diacylglycerol kinases regulate the intracellular concentration of diacylglycerol through its phosphorylation, producing phosphatidic acid. The specific role of the enzyme encoded by this gene is undetermined, however, it may play a crucial role in the production of phosphatidic acid in the retina or in recessive forms of retinal degeneration. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001308637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O75912", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75912" } ], "glycoeffect": [], "start_pos": 185, "end_pos": 185, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "V", "sequence_mut": "I", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "7", "chr_pos": "137678610", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "V185", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] }, { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75912" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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"length": 1057, "header": "tr|A0A087WV00-1|A0A087WV00_HUMAN Computationally mapped isoform of Diacylglycerol kinase OS=Homo sapiens OX=9606 GN=DGKI PE=1 SV=2 CANONICAL=O75912-1" }, "locus": { "chromosome": "7", "start_pos": 137846862, "end_pos": 137391223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000614521.2", "url": "https://www.ensembl.org/id/ENST00000614521.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000479053.2", "url": "https://www.ensembl.org/id/ENSP00000479053.2" } ] } }, { "isoform_ac": "A0A9L9PXR3-1", "url": "", "sequence": { "sequence": "MWDRWKEKHPWMGRRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNV", "length": 66, "header": "tr|A0A9L9PXR3-1|DGKI_HUMAN Computationally mapped isoform of Diacylglycerol kinase iota OS=Homo sapiens OX=9606 GN=DGKI PE=1 SV=1 CANONICAL=O75912-1" }, "locus": { "chromosome": "7", "start_pos": 137774638, "end_pos": 137678608, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000483619.1", "url": "https://www.ensembl.org/id/ENST00000483619.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000516651.1", "url": "https://www.ensembl.org/id/ENSP00000516651.1" } ] } }, { "isoform_ac": "E7EM72-1", "url": "", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDDRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV", "length": 1047, "header": "tr|E7EM72-1|E7EM72_HUMAN Computationally mapped isoform of Diacylglycerol kinase OS=Homo sapiens OX=9606 GN=DGKI PE=1 SV=1 CANONICAL=O75912-1" }, "locus": { "chromosome": "7", "start_pos": 137846862, "end_pos": 137391223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000446122.5", "url": "https://www.ensembl.org/id/ENST00000446122.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000399131.1", "url": "https://www.ensembl.org/id/ENSP00000399131.1" } ] } }, { "isoform_ac": "E7EWQ4-1", "url": "", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQTADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV", "length": 1078, "header": "tr|E7EWQ4-1|DGKI_HUMAN Computationally mapped isoform of Diacylglycerol kinase iota OS=Homo sapiens OX=9606 GN=DGKI PE=1 SV=2 CANONICAL=O75912-1" }, "locus": { "chromosome": "7", "start_pos": 137846862, "end_pos": 137391223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000424189.6", "url": "https://www.ensembl.org/id/ENST00000424189.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000396078.2", "url": "https://www.ensembl.org/id/ENSP00000396078.2" } ] } }, { "isoform_ac": "E9PFX6-1", "url": "", "sequence": { "sequence": "MLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV", "length": 734, "header": "tr|E9PFX6-1|DGKI_HUMAN Computationally mapped isoform of Diacylglycerol kinase iota OS=Homo sapiens OX=9606 GN=DGKI PE=1 SV=1 CANONICAL=O75912-1" }, "locus": { "chromosome": "7", "start_pos": 137619916, "end_pos": 137391223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000453654.6", "url": "https://www.ensembl.org/id/ENST00000453654.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000392161.1", "url": "https://www.ensembl.org/id/ENSP00000392161.1" } ] } }, { "isoform_ac": "O75912-1", "url": "", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAAAAAAAASPPGPCSGAACAPSAAAGAGAMNPSSSAGEEKGATGGSSSSGSGAGSCCLGAEGGADPRGAGSAAAAGAAALDEPAAAGQKEKDEALEEKLRNLTFRKQVSYRKAISRAGLQHLAPAHPLSLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTVVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGFHYDKEKLREASISDWLRTIAGELVQSFGAIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDHETSFPRALSAQRLSPRWCFLDDRSQEHLHFVMEISQDEIFILDPDMVVSQPAGTPPGMPDLVVEQASGISDWWNPALRKRMLSDSGLGMIAPYYEDSDLKDLSHSRVLQSPVSSEDHAILQAVIAGDLMKLIESYKNGGSLLIQGPDHCSLLHYAAKTGNGEIVKYILDHGPSELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRKTDSKGKTPQERAQQAGDPDLAAYLESRQNYKVIGHEDLETAV", "length": 1065, "header": "sp|O75912-1|DGKI_HUMAN Isoform 1 of Diacylglycerol kinase iota OS=Homo sapiens OX=9606 GN=DGKI PE=1 SV=1 CANONICAL=O75912-1" }, "locus": { "chromosome": "7", "start_pos": 137846862, "end_pos": 137391223, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000288490.9", "url": "https://www.ensembl.org/id/ENST00000288490.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000288490.4", "url": "https://www.ensembl.org/id/ENSP00000288490.4" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Evaluation of human diacylglycerol kinase iota, DGKI, a homolog of Drosophila rdgA, in inherited retinopathy mapping to 7q.", "journal": "Mol. Vis.", "date": "2000", "authors": "Bowne SJ, Sullivan LS, Ding L, Traer E, Prescott SM, Birch DG, Kennan A, Humphries P, Daiger SP", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "reference": [ { "type": "PubMed", "id": "10706894", "url": "https://glygen.org/publication/PubMed/10706894" } ] }, { "title": "Properties and functions of diacylglycerol kinases.", "journal": "Cellular signalling", "date": "2000", "authors": "van Blitterswijk WJ, Houssa B", "evidence": [ { "database": "Reactome", "id": "R-HSA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508" } ], "reference": [ { "type": "PubMed", "id": "11080611", "url": "https://glygen.org/publication/PubMed/11080611" } ] }, { "title": "The versatility and universality of calcium signalling.", "journal": "Nature reviews. Molecular cell biology", "date": "2000", "authors": "Berridge MJ, Lipp P, Bootman MD", "evidence": [ { "database": "Reactome", "id": "R-HSA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508" } ], "reference": [ { "type": "PubMed", "id": "11413485", "url": "https://glygen.org/publication/PubMed/11413485" } ] }, { "title": "Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Riccio A, Mattei C, Kelsell RE, Medhurst AD, Calver AR, Randall AD, Davis JB, Benham CD, Pangalos MN", "evidence": [ { "database": "Reactome", "id": "R-HSA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508" } ], "reference": [ { "type": "PubMed", "id": "11805119", "url": "https://glygen.org/publication/PubMed/11805119" } ] }, { "title": "Diacylglycerol kinase iota regulates Ras guanyl-releasing protein 3 and inhibits Rap1 signaling.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2005", "authors": "Regier Debra S, Higbee Jared, Lund Katrina M, Sakane Fumio, Prescott Stephen M, Topham Matthew K", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "reference": [ { "type": "PubMed", "id": "15894621", "url": "https://glygen.org/publication/PubMed/15894621" } ] }, { "title": "Lipid activation of protein kinases.", "journal": "Journal of lipid research", "date": "2009", "authors": "Newton AC", "evidence": [ { "database": "Reactome", "id": "R-HSA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508" } ], "reference": [ { "type": "PubMed", "id": "19033211", "url": "https://glygen.org/publication/PubMed/19033211" } ] }, { "title": "Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.", "journal": "Molecular psychiatry", "date": "2009", "authors": "Moskvina V, Craddock N, Holmans P, Nikolov I, Pahwa JS, Green E, Owen MJ, O'Donovan MC", "evidence": [ { "database": "RefSeq", "id": "NP_001308637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" } ], "reference": [ { "type": "PubMed", "id": "19065143", "url": "https://glygen.org/publication/PubMed/19065143" } ] }, { "title": "DGKiota regulates presynaptic release during mGluR-dependent LTD.", "journal": "EMBO J.", "date": "2011", "authors": "Yang J, Seo J, Nair R, Han S, Jang S, Kim K, Han K, Paik SK, Choi J, Lee S, Bae YC, Topham MK, Prescott SM, Rhee JS, Choi SY, Kim E", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "reference": [ { "type": "PubMed", "id": "21119615", "url": "https://glygen.org/publication/PubMed/21119615" } ] }, { "title": "Purification, cDNA-cloning and expression of human diacylglycerol kinase.", "journal": "FEBS letters", "date": "1990", "authors": "Schaap D, de Widt J, van der Wal J, Vandekerckhove J, van Damme J, Gussow D, Ploegh HL, van Blitterswijk WJ, van der Bend RL", "evidence": [ { "database": "Reactome", "id": "R-HSA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508" } ], "reference": [ { "type": "PubMed", "id": "2175712", "url": "https://glygen.org/publication/PubMed/2175712" } ] }, { "title": "Evaluations of the selectivities of the diacylglycerol kinase inhibitors R59022 and R59949 among diacylglycerol kinase isozymes using a new non-radioactive assay method.", "journal": "Pharmacology", "date": "2013", "authors": "Sato Mayu, Liu Ke, Sasaki Saori, Kunii Naoko, Sakai Hiromichi, Mizuno Hirotaka, Saga Hiroshi, Sakane Fumio", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "reference": [ { "type": "PubMed", "id": "23949095", "url": "https://glygen.org/publication/PubMed/23949095" } ] }, { "title": "DGKI methylation status modulates the prognostic value of MGMT in glioblastoma patients treated with combined radio-chemotherapy with temozolomide.", "journal": "PloS one", "date": "2014", "authors": "Etcheverry A, Aubry M, Idbaih A, Vauleon E, Marie Y, Menei P, Boniface R, Figarella-Branger D, Karayan-Tapon L, Quillien V, Sanson M, de Tayrac M, Delattre JY, Mosser J", "evidence": [ { "database": "RefSeq", "id": "NP_001308637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" } ], "reference": [ { "type": "PubMed", "id": "25233099", "url": "https://glygen.org/publication/PubMed/25233099" } ] }, { "title": "Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets.", "journal": "Frontiers in immunology", "date": "2022", "authors": "Bai M, Ke S, Yu H, Xu Y, Yu Y, Lu S, Wang C, Huang J, Ma Y, Dai W, Wu Y", "evidence": [ { "database": "RefSeq", "id": "NP_001308637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308637" } ], "reference": [ { "type": "PubMed", "id": "36059514", "url": "https://glygen.org/publication/PubMed/36059514" } ] }, { "title": "The extended protein kinase C superfamily.", "journal": "The Biochemical journal", "date": "1998", "authors": "Mellor H, Parker PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508" } ], "reference": [ { "type": "PubMed", "id": "9601053", "url": "https://glygen.org/publication/PubMed/9601053" } ] }, { "title": "The cloning and characterization of a novel human diacylglycerol kinase, DGKiota.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Ding L, Traer E, McIntyre TM, Zimmerman GA, Prescott SM", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "reference": [ { "type": "PubMed", "id": "9830018", "url": "https://glygen.org/publication/PubMed/9830018" } ] }, { "title": "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.", "journal": "Nature", "date": "1999", "authors": "Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G", "evidence": [ { "database": "Reactome", "id": "R-HSA-114508", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508" } ], "reference": [ { "type": "PubMed", "id": "9930701", "url": "https://glygen.org/publication/PubMed/9930701" } ] } ], "pathway": [ { "id": "hsa:9162", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9162", "resource": "KEGG Pathway" }, { "id": "R-HSA-114508", "name": "Effects of PIP2 hydrolysis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-114508", "resource": "Reactome", "description": "Effects of PIP2 hydrolysis" } ], "orthologs": [ { "uniprot_canonical_ac": "D3YWQ0-1", "protein_name": "Diacylglycerol kinase iota", "gene_name": "Dgki", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPTGLCSGTTSASFAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGADPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQETKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALEMYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDIHQVQAADLRRVSAPPGSFTIPQSVPDRLRIRVNKISLQDYEGLHYDKDKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRALSAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVLTGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGDIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV", "length": 1071 }, "evidence": [ { "id": "45924009", "url": "http://www.informatics.jax.org/homology/45924009", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "F1MAB7-1", "protein_name": "Diacylglycerol kinase iota", "gene_name": "Dgki", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MDAAGRGCHLLPLPAARGPARAPAASSALSPAGLCSGTASASSAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGVDPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKEKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRAISAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVITGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGEIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV", "length": 1050 }, "evidence": [ { "id": "45924009", "url": "http://www.informatics.jax.org/homology/45924009", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "ATP-dependent diacylglycerol kinase activity", "id": "GO:0004143", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004143", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "GTPase inhibitor activity", "id": "GO:0005095", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005095", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "small GTPase binding", "id": "GO:0031267", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 15, "go_terms": [ { "name": "protein kinase C-activating G protein-coupled receptor signaling pathway", "id": "GO:0007205", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007205", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "platelet activation", "id": "GO:0030168", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030168", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "glycerolipid metabolic process", "id": "GO:0046486", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046486", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "diacylglycerol metabolic process", "id": "GO:0046339", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046339", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "lipid phosphorylation", "id": "GO:0046834", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046834", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "intracellular signal transduction", "id": "GO:0035556", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "regulation of synaptic transmission, glutamatergic", "id": "GO:0051966", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051966", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "positive regulation of Ras protein signal transduction", "id": "GO:0046579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046579", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "habituation", "id": "GO:0046959", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046959", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "regulation of long-term synaptic depression", "id": "GO:1900452", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1900452", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "excitatory postsynaptic potential", "id": "GO:0060079", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060079", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "Ras protein signal transduction", "id": "GO:0007265", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "neurotransmitter secretion", "id": "GO:0007269", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007269", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "presynaptic modulation of chemical synaptic transmission", "id": "GO:0099171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099171", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 17, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "postsynaptic density", "id": "GO:0014069", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0014069", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "axon", "id": "GO:0030424", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "dendritic spine", "id": "GO:0043197", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "synaptic vesicle membrane", "id": "GO:0030672", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030672", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "synaptic membrane", "id": "GO:0097060", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097060", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "protein-containing complex", "id": "GO:0032991", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "glutamatergic synapse", "id": "GO:0098978", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098978", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "postsynapse", "id": "GO:0098794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098794", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "presynapse", "id": "GO:0098793", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098793", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "guanyl-nucleotide exchange factor complex", "id": "GO:0032045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032045", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" }, { "name": "Schaffer collateral - CA1 synapse", "id": "GO:0098685", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098685", "evidence": [ { "database": "UniProtKB", "id": "O75912", "url": "https://www.uniprot.org/uniprot/O75912" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 124, "end_pos": 126, "annotation": "n_glycosylation_sequon" }, { "start_pos": 184, "end_pos": 186, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "10272", "name": "", "equation": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "F1LZW2-1", "D3ZEY4-1", "P51556-1", "P49620-1", "P49621-1", "A0A096UWG9-1", "F1MAB7-1", "D3ZSZ6-1", "F1M5T2-1", "D3Z9L0-1", "P52429-1", "Q53H12-1", "Q86XP1-1", "O75912-1", "P52824-1", "P49619-1", "Q16760-1", "Q5KSL6-1", "Q9Y6T7-1", "P23743-1", "Q13574-2", "Q91WG7-1", "D3YXJ0-1", "D3YWQ0-1", "Q9ESW4-1", "Q9R1C6-1", "O88673-1", "Q80UP3-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1", "F6UUZ3-1", "P34125-1", "Q01583-4", "Q09103-1", "A8JQ65-1", "A0A0B4KHZ4-1", "Q7K579-1" ], "evidence": [ { "id": "10272", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10272" } ] }, { "id": "40323", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "P51556-1", "P49620-1", "P49621-1", "F1LZW2-1", "D3ZEY4-1", "F1MAB7-1", "A0A096UWG9-1", "F1M5T2-1", "D3ZSZ6-1", "O75912-1", "Q9Y6T7-1", "P52429-1", "P49619-1", "Q16760-1", "P52824-1", "P23743-1", "Q13574-2", "D3YWQ0-1", "Q80UP3-1", "O88673-1", "Q91WG7-1", "Q9R1C6-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1" ], "evidence": [ { "id": "40323", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40323" } ] }, { "id": "40327", "name": "", "equation": "1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O08560-1", "P51556-1", "P49620-1", "P49621-1", "A0A096UWG9-1", "F1LZW2-1", "F1MAB7-1", "D3ZSZ6-1", "F1M5T2-1", "D3ZEY4-1", "Q53H12-1", "O75912-1", "P23743-1", "P52824-1", "P52429-1", "Q86XP1-1", "Q9Y6T7-1", "P49619-1", "Q16760-1", "Q5KSL6-1", "Q13574-2", "Q9ESW4-1", "O88673-1", "Q80UP3-1", "D3YWQ0-1", "D3YXJ0-1", "Q91WG7-1", "Q9R1C6-1", "Q6P5E8-1", "Q6NS52-1", "E9PUQ8-1", "F6UUZ3-1" ], "evidence": [ { "id": "40327", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40327" } ] }, { "id": "40339", "name": "", "equation": "1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycerol + ATP = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + ADP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P49620-1", "P49621-1", "F1MAB7-1", "P52429-1", "P49619-1", "Q9Y6T7-1", "O75912-1", "Q91WG7-1", "Q9R1C6-1", "Q6NS52-1", "D3YWQ0-1" ], "evidence": [ { "id": "40339", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40339" } ] }, { "id": "R-HSA-426240", "name": "DAG kinase produces phosphatidic acid from DAG", "equation": "", "summary": "Diacylglycerol kinases (DGKs) are intracellular lipid kinases that use ATP to phosphorylate diacylglycerol (DAG)., generating phosphatidic acid (PA). This lowers membrane DAG levels, regulating signalling proteins that require DAG for membrane association such as Protein Kinase C. PA is a signalling molecule that regulates Raf-1 and PKC zeta, and a substrate for the resynthesis of phosphatidylinositol.", "cellular_location": "cytosol, plasma membrane", "input_participant_list": [ "R-ALL-114519" ], "output_participant_list": [], "enzyme_list": [ "O75912-1", "Q16760-1", "Q86XP1-1", "P52429-1", "P23743-1", "P49619-1", "Q13574-2", "Q9Y6T7-1", "P52824-1", "Q5KSL6-1" ], "evidence": [ { "id": "R-HSA-426240", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-426240" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-114519", "participant_name": "DAG [plasma membrane]", "crossref": [ { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "17815", "database": "ChEBI", "url": "" }, { "id": "17815", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A096UWG9", "gene_name": "Dgke", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A096UWG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096UWG9" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A096UWG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096UWG9" } ] } ] }, { "uniprot_ac": "A0A0B4KHZ4", "gene_name": "Dmel\\CG31140", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] }, { "ec_number": "2.7.1.23", "activity": "ATP + NAD(+) = ADP + H(+) + NADP(+).", "evidence": [ { "id": "A0A0B4KHZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B4KHZ4" } ] } ] }, { "uniprot_ac": "A8JQ65", "gene_name": "", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "A8JQ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8JQ65" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "A8JQ65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8JQ65" } ] } ] }, { "uniprot_ac": "D3YWQ0", "gene_name": "Dgki", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3YWQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3YWQ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YWQ0" } ] } ] }, { "uniprot_ac": "D3YXJ0", "gene_name": "Dgkh", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3YXJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YXJ0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3YXJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3YXJ0" } ] } ] }, { "uniprot_ac": "D3Z9L0", "gene_name": "Agk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.94", "activity": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate.", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.138", "activity": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+).", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.94", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] }, { "ec_number": "2.7.1.138", "activity": "", "evidence": [ { "id": "D3Z9L0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9L0" } ] } ] }, { "uniprot_ac": "D3ZEY4", "gene_name": "Dgkq", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] }, { "ec_number": "2.7.1.93", "activity": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] }, { "ec_number": "2.7.1.93", "activity": "", "evidence": [ { "id": "D3ZEY4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEY4" } ] } ] }, { "uniprot_ac": "D3ZSZ6", "gene_name": "Dgkh", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "D3ZSZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ6" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "D3ZSZ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSZ6" } ] } ] }, { "uniprot_ac": "E9PUQ8", "gene_name": "Dgkd", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "E9PUQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PUQ8" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "E9PUQ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PUQ8" } ] } ] }, { "uniprot_ac": "F1LZW2", "gene_name": "Dgkk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1LZW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LZW2" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1LZW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LZW2" } ] } ] }, { "uniprot_ac": "F1M5T2", "gene_name": "Dgkd", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1M5T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5T2" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1M5T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5T2" } ] } ] }, { "uniprot_ac": "F1MAB7", "gene_name": "Dgki", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F1MAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAB7" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F1MAB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAB7" } ] } ] }, { "uniprot_ac": "F6UUZ3", "gene_name": "Dgkk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "F6UUZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F6UUZ3" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "F6UUZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F6UUZ3" } ] } ] }, { "uniprot_ac": "O08560", "gene_name": "Dgkz", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] }, { "ec_number": "2.7.1.93", "activity": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] }, { "ec_number": "2.7.1.93", "activity": "", "evidence": [ { "id": "O08560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08560" } ] } ] }, { "uniprot_ac": "O75912", "gene_name": "DGKI", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O75912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75912" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O75912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75912" } ] } ] }, { "uniprot_ac": "O88673", "gene_name": "Dgka", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] }, { "ec_number": "2.7.1.93", "activity": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] }, { "ec_number": "2.7.1.93", "activity": "", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "O88673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88673" } ] } ] }, { "uniprot_ac": "P23743", "gene_name": "DGKA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] }, { "ec_number": "2.7.1.93", "activity": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] }, { "ec_number": "2.7.1.93", "activity": "", "evidence": [ { "id": "P23743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23743" } ] } ] }, { "uniprot_ac": "P34125", "gene_name": "dgkA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P34125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34125" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P34125", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34125" } ] } ] }, { "uniprot_ac": "P49619", "gene_name": "DGKG", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49619" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49619" } ] } ] }, { "uniprot_ac": "P49620", "gene_name": "Dgkg", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49620" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49620" } ] } ] }, { "uniprot_ac": "P49621", "gene_name": "Dgkb", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P49621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49621" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P49621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49621" } ] } ] }, { "uniprot_ac": "P51556", "gene_name": "Dgka", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P51556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51556" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P51556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51556" } ] }, { "ec_number": "2.7.1.93", "activity": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P51556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51556" } ] }, { "ec_number": "2.7.1.93", "activity": "", "evidence": [ { "id": "P51556", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51556" } ] } ] }, { "uniprot_ac": "P52429", "gene_name": "DGKE", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P52429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52429" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P52429", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52429" } ] } ] }, { "uniprot_ac": "P52824", "gene_name": "DGKQ", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P52824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52824" } ] }, { "ec_number": "2.7.1.93", "activity": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "P52824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52824" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "P52824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52824" } ] }, { "ec_number": "2.7.1.93", "activity": "", "evidence": [ { "id": "P52824", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52824" } ] } ] }, { "uniprot_ac": "Q01583", "gene_name": "Dgk", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q01583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01583" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q01583", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01583" } ] } ] }, { "uniprot_ac": "Q09103", "gene_name": "rdgA", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q09103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09103" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q09103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09103" } ] } ] }, { "uniprot_ac": "Q13574", "gene_name": "DGKZ", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q13574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13574" } ] }, { "ec_number": "2.7.1.93", "activity": "1-O-alkyl-sn-glycerol + ATP = 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q13574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13574" } ] }, { "ec_number": "2.7.1.93", "activity": "", "evidence": [ { "id": "Q13574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13574" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q13574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13574" } ] } ] }, { "uniprot_ac": "Q16760", "gene_name": "DGKD", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q16760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16760" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q16760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16760" } ] } ] }, { "uniprot_ac": "Q53H12", "gene_name": "AGK", "activity": [ { "ec_number": "2.7.1.107", "activity": "a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+).", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.94", "activity": "a monoacylglycerol + ATP = ADP + H(+) + monoacyl-sn-glycero-3-phosphate.", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.138", "activity": "an N-acylsphing-4-enine + ATP = ADP + an N-acylsphing-4-enine 1-phosphate + H(+).", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.107", "activity": "", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.138", "activity": "", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] }, { "ec_number": "2.7.1.94", "activity": "", "evidence": [ { "id": "Q53H12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q53H12" } ] } ] }, { "uniprot_ac": "Q5KSL6", "gene_name": "DGKK", "activity": [ { "ec_number": "2.7.1.107", 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