{ "uniprot_canonical_ac": "O75879-1", "uniprot_ac": "O75879", "uniprot_id": "GATB_HUMAN", "mass": { "chemical_mass": 61864.0, "monoisotopic_mass": 61864.0 }, "refseq": { "ac": "NP_004555", "name": "glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555" }, "gene_names": [ { "name": "GATB", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75879", "id": "O75879" }, { "name": "COXPD41; HSPC199; PET112; PET112L", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555", "id": "NP_004555" }, { "name": "GATB", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555", "id": "NP_004555" }, { "name": "HSPC199", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75879", "id": "O75879" }, { "name": "PET112L", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75879", "id": "O75879" }, { "name": "PET112", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75879", "id": "O75879" } ], "protein_names": [ { "name": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75879" }, { "name": "6.3.5.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75879" }, { "name": "Cytochrome c oxidase assembly factor PET112 homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75879" }, { "name": "Glu-AdT subunit B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75879" }, { "name": "cytochrome oxidase assembly factor PET112 homolog; cytochrome c oxidase assembly factor PET112 homolog; glutamyl-tRNA(Gln) amidotransferase, subunit B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555", "id": "NP_004555" }, { "name": "glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555", "id": "NP_004555" } ], "function": [ { "annotation": "Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).", "evidence": [ { "database": "UniProtKB", "id": "D6REA0", "url": "https://www.uniprot.org/uniprot/D6REA0#function" }, { "database": "UniProtKB", "id": "MF_03147", "url": "https://www.uniprot.org/uniprot/MF_03147#function" }, { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879#function" }, { "database": "PubMed", "id": "19805282", "url": "https://glygen.org/publication/PubMed/19805282" } ] }, { "annotation": "Observational study of gene-disease association. 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "common_name": "Human" } ], "gene": [ { "name": "GATB", "url": "https://www.uniprot.org/uniprot/O75879", "locus": { "chromosome": "4", "start_pos": 151670504, "end_pos": 151761007, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000059691", "url": "https://www.ensembl.org/id/ENSG00000059691" } ] } } ], "crossref": [ { "id": "ENSG00000059691", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000059691", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O75879", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75879", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "6.3.5.7", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=6.3.5.7&UniProtAcc=O75879", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "GATB", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=GATB", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "5188", "url": "https://www.ncbi.nlm.nih.gov/gene/5188", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "8849", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8849", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "D6REA0", "url": "https://www.ebi.ac.uk/intact/interactors/id:D6REA0*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "O75879", "url": "https://www.ebi.ac.uk/intact/interactors/id:O75879*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR003789", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003789", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR004413", "url": "https://www.ebi.ac.uk/interpro/entry/IPR004413", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006075", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006075", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014746", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014746", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017958", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017958", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017959", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017959", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018027", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018027", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR023168", "url": "https://www.ebi.ac.uk/interpro/entry/IPR023168", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:5188", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5188", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603645", "url": "http://www.omim.org/entry/603645", "database": "MIM", "categories": [ "Other" ] }, { "id": "618838", "url": "http://www.omim.org/entry/618838", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O75879", "url": "https://www.nextprot.org/entry/NX_O75879", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "ARKWWMG", "url": "https://omabrowser.org/oma/group/ARKWWMG/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5474932at2759", "url": "http://www.orthodb.org/?query=5474932at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11659", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11659", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11659:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11659:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF02637", "url": "http://pfam.xfam.org/family/PF02637", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02934", "url": "http://pfam.xfam.org/family/PF02934", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O75879", "url": "https://pharos.nih.gov/targets/O75879", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75879", "url": "http://purl.obolibrary.org/obo/PR_O75879", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_004555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "17521", "url": "https://www.rhea-db.org/rhea/17521", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "B4E0P2", "url": "https://www.uniprot.org/uniprot/B4E0P2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "B4E0P2-1", "url": "https://www.uniprot.org/uniprot/B4E0P2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RDU9", "url": "https://www.uniprot.org/uniprot/D6RDU9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RDU9-1", "url": "https://www.uniprot.org/uniprot/D6RDU9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6REA0", "url": "https://www.uniprot.org/uniprot/D6REA0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6REA0-1", "url": "https://www.uniprot.org/uniprot/D6REA0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RGY4", "url": "https://www.uniprot.org/uniprot/D6RGY4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "D6RGY4-1", "url": "https://www.uniprot.org/uniprot/D6RGY4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y8G7", "url": "https://www.uniprot.org/uniprot/H0Y8G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y8G7-1", "url": "https://www.uniprot.org/uniprot/H0Y8G7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y9F2", "url": "https://www.uniprot.org/uniprot/H0Y9F2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y9F2-1", "url": "https://www.uniprot.org/uniprot/H0Y9F2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y9W6", "url": "https://www.uniprot.org/uniprot/H0Y9W6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0Y9W6-1", "url": "https://www.uniprot.org/uniprot/H0Y9W6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75879-1", "url": "https://www.uniprot.org/uniprot/O75879-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPAGYQITQQRLPIAVNGSLIYGVCAGKKQSQVIPKTVRIKQIQLEQDSGKSLHDNLRSQTLIDLNRAGVGLLEVVLEPDMSCGEEAATAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSIRFLAKAIDYEIQRQINELENGGEILNETRSFHHKLGCTMSMRDKEGKQDYRFMPEPNLPPLVLYDATSLPAGADPQQVINIDQIRETLPELPSVTREKLVQQYGMLLEHSFTLLNEVGLLEFFQNVIKETRAEPKKVTSWVLNTFLGYLKQQNLAVSESPVTPSALAELLDLLDSRTISSSAAKQVFEELWKREGKTPGQIVSEKQLELMQDQGALEQLCHSVMEAHPQVVMDVKNRNPRAINKLIGLVRKATQSRADPVMIKEILEKKLSL", "length": 557, "header": "sp|O75879-1|GATB_HUMAN Isoform 1 of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "isoforms": [ { "isoform_ac": "B4E0P2-1", "url": "", "sequence": { "sequence": "MLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPRAS", "length": 146, "header": "tr|B4E0P2-1|GATB_HUMAN Computationally mapped isoform of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151760970, "end_pos": 151708093, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000511538.5", "url": "https://www.ensembl.org/id/ENST00000511538.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000421240.1", "url": "https://www.ensembl.org/id/ENSP00000421240.1" } ] } }, { "isoform_ac": "D6RDU9-1", "url": "", "sequence": { "sequence": "MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPAGYQITQQRLPIAVNGSLIYGVCAGKKQSQVIPKTVRIKQIQLEQDSGKSLHDNLRSQTLIDLNRAGVGLLEVVLEPDMSCGEEAATAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSIRFLAKAIDYEIQRQINELENGGEILNETRSFHHKLGCTMSMRDKEGKQDYRWLLLMAKYRYISGAGAYFKFI", "length": 357, "header": "tr|D6RDU9-1|GATB_HUMAN Computationally mapped isoform of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151760982, "end_pos": 151703787, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000512306.5", "url": "https://www.ensembl.org/id/ENST00000512306.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000420831.1", "url": "https://www.ensembl.org/id/ENSP00000420831.1" } ] } }, { "isoform_ac": "D6REA0-1", "url": "", "sequence": { "sequence": "MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPAGYQITQQRLPIAVNGSLIYGVCAGKKQSQVIPKTVRIKQIQLEQDSGKSLHDNLRSQTLIDLNRAEGQLRVDANISVHHPGEPLGVRTEVKNLNSIRFLAKAIDYEIQRQINELENGGEILNETRSFHHKLGCTMSMRDKEGKQDYRFMPEPNLPPLVLYDATSLPAGADPQQVINIDQIRETLPELPSVTREKLVQQYGMLLEHSFTLLNEVGLLEFFQNVIKETRAEPKKVTSWVLNTFLGYLKQQNLAVSESPVTPSALAELLDLLDSRTISSSAAKQVFEELWKREGKTPGQIVSEKQLELMQDQGALEQLCHSVMEAHPQVVMDVKNRNPRAINKLIGLVRKATQSRADPVMIKEILEKKLSL", "length": 516, "header": "tr|D6REA0-1|GATB_HUMAN Computationally mapped isoform of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151760982, "end_pos": 151671177, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000515812.5", "url": "https://www.ensembl.org/id/ENST00000515812.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000426859.1", "url": "https://www.ensembl.org/id/ENSP00000426859.1" } ] } }, { "isoform_ac": "D6RGY4-1", "url": "", "sequence": { "sequence": "MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPSEDSPS", "length": 115, "header": "tr|D6RGY4-1|GATB_HUMAN Computationally mapped isoform of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151760982, "end_pos": 151722198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000508611.1", "url": "https://www.ensembl.org/id/ENST00000508611.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000421105.1", "url": "https://www.ensembl.org/id/ENSP00000421105.1" } ] } }, { "isoform_ac": "H0Y8G7-1", "url": "", "sequence": { "sequence": "XRVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPGRSRVR", "length": 136, "header": "tr|H0Y8G7-1|GATB_HUMAN Computationally mapped isoform of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151760930, "end_pos": 151716983, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000503160.5", "url": "https://www.ensembl.org/id/ENST00000503160.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000421005.1", "url": "https://www.ensembl.org/id/ENSP00000421005.1" } ] } }, { "isoform_ac": "H0Y9F2-1", "url": "", "sequence": { "sequence": "XRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPRAS", "length": 141, "header": "tr|H0Y9F2-1|GATB_HUMAN Computationally mapped isoform of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151760953, "end_pos": 151708091, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000515884.5", "url": "https://www.ensembl.org/id/ENST00000515884.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000423999.1", "url": "https://www.ensembl.org/id/ENSP00000423999.1" } ] } }, { "isoform_ac": "H0Y9W6-1", "url": "", "sequence": { "sequence": "XFMPEPNLPPLVLYDATSLPAGADPQQVINIDQIRETLPELPSVTREKLVQQYGMLLEHSFTLLNEVGLLEFFQNVIKETRAEPKKVTSWVLNTFLGYLKQQNLAVSERCLRNCGRGKARLQGRLFQKSSLN", "length": 132, "header": "tr|H0Y9W6-1|GATB_HUMAN Computationally mapped isoform of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151701518, "end_pos": 151672825, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000510720.1", "url": "https://www.ensembl.org/id/ENST00000510720.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000425294.1", "url": "https://www.ensembl.org/id/ENSP00000425294.1" } ] } }, { "isoform_ac": "O75879-1", "url": "", "sequence": { "sequence": "MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPAGYQITQQRLPIAVNGSLIYGVCAGKKQSQVIPKTVRIKQIQLEQDSGKSLHDNLRSQTLIDLNRAGVGLLEVVLEPDMSCGEEAATAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSIRFLAKAIDYEIQRQINELENGGEILNETRSFHHKLGCTMSMRDKEGKQDYRFMPEPNLPPLVLYDATSLPAGADPQQVINIDQIRETLPELPSVTREKLVQQYGMLLEHSFTLLNEVGLLEFFQNVIKETRAEPKKVTSWVLNTFLGYLKQQNLAVSESPVTPSALAELLDLLDSRTISSSAAKQVFEELWKREGKTPGQIVSEKQLELMQDQGALEQLCHSVMEAHPQVVMDVKNRNPRAINKLIGLVRKATQSRADPVMIKEILEKKLSL", "length": 557, "header": "sp|O75879-1|GATB_HUMAN Isoform 1 of Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Homo sapiens OX=9606 GN=GATB PE=1 SV=1 CANONICAL=O75879-1" }, "locus": { "chromosome": "4", "start_pos": 151760982, "end_pos": 151671177, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000263985.11", "url": "https://www.ensembl.org/id/ENST00000263985.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000263985.6", "url": "https://www.ensembl.org/id/ENSP00000263985.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 107, "end_pos": 107, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75879", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75879" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr107" }, { "start_pos": 95, "end_pos": 95, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75879", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75879" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser95" }, { "start_pos": 98, "end_pos": 98, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75879", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75879" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser98" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Biogenesis of glutaminyl-mt tRNAGln in human mitochondria.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Nagao A, Suzuki T, Katoh T, Sakaguchi Y, Suzuki T", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" }, { "database": "RefSeq", "id": "NP_004555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555" } ], "reference": [ { "type": "PubMed", "id": "19805282", "url": "https://glygen.org/publication/PubMed/19805282" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O75879", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75879" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.", "journal": "PloS one", "date": "2010", "authors": "Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ", "evidence": [ { "database": "RefSeq", "id": "NP_004555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004555" } ], "reference": [ { "type": "PubMed", "id": "20877624", "url": "https://glygen.org/publication/PubMed/20877624" } ] }, { "title": "Pathogenic variants in glutamyl-tRNA(Gln) amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder.", "journal": "Nature communications", "date": "2018", "authors": "Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, Gonzalez C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B Jr, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernandez-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "reference": [ { "type": "PubMed", "id": "30283131", "url": "https://glygen.org/publication/PubMed/30283131" } ] }, { "title": "Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain.", "journal": "Genomics", "date": "1998", "authors": "Petruzzella V, Tiranti V, Fernandez P, Ianna P, Carrozzo R, Zeviani M", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "reference": [ { "type": "PubMed", "id": "9878253", "url": "https://glygen.org/publication/PubMed/9878253" } ] } ], "pathway": [ { "id": "hsa:5188", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5188", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P33893-1", "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "gene_name": "PET112", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MLRLARFYSLARTKAIHSHGAPFRPEYALKCGLEIHTQLNTKNKLFSQSTNSATSLVDAPNHHTSYYDIALPGTQPVLNLEAILFAMKLSLALGSQVNSISQFDRKHYFYGDQPQGYQLTQHYRPFARGGKINLSKELDDIDESAKEIGILQLQIEQDTGKSHYTETDKDVITLVDLNRSNVPLIELVTKPDFSDIKQVRAFIKKYQNLVRHLHISSGDLETGAMRVDVNLSINEYARVELKNLPNTSSIINAIKYEYQRQVELISVGDTSSLMEPETRGWTGSSTVKLRSKETTIDYRYMPDPELPYINLAPDVISGVRGLMPQLPDDIMRILMKKPYQLSLKDAKILTYNSNQNDMYNHEALRSYYLDTFREFSKLAGERSNAKLPTNWIIHEFLGDLNKLQIPLAKAKEILPPPVFAQFLKLLHEEVISATSGKMLLFHILENFEQSNCQDLSIPDFSKLIEKFELHAINQVDPQELMDLCNDVIAQHTDDTFIRNLVTGKKKSSLKFLIGQGMRRSQGRIKANEFEKKFKEILNIQW", "length": 541 }, "evidence": [ { "id": "O75879", "url": "https://omabrowser.org/oma/group/O75879/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "Q99JT1-1", "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "gene_name": "Gatb", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAPMLRLGFPGRRWALTWLDGGSRHRSGSQTGPTSNWARRQSSVAQPSLHTAQKPRKGEHKWAAVVGLEIHAQISSNSKLFSGAQVCFAAPPNSLVSYFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYSDLPAGYQITQQRLPIAANGHLTYCIYLGKKPSQVTTKTVRIKQIQLEQDSGKSLHDDLRSQTLIDLNRAGIGLLEVVLEPDLCCGEEAALAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSLRFLAKAIDYEIQRQITELENGGEILNETRSFDYKLGCTMPMRDKEGKQDYRFMPEPNLPPLVLYDDTSLPRGADSQQVINIDQLRDMLPELPSATRERLVQQYGMLPEHSFALLNEVGLLEFFQNVIKETRTEPKKVTNWVLNTFLCYLKQQNLAVSESPVTPSALAELLNLLDRKAISSSAAKQVFEELWKGEGKTAAQIVSEQQLELMQDQEALEKLCQTTIDGHPQVVMDVKKRNPKAINKLIGLVRKASHSRADPALIKKILERKLSL", "length": 557 }, "evidence": [ { "id": "45919261", "url": "http://www.informatics.jax.org/homology/45919261", "database": "MGI" }, { "id": "O75879", "url": "https://omabrowser.org/oma/group/O75879/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VCD0-1", "protein_name": "Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial", "gene_name": "GatB", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MHYSIIRKLVTAPKLANVPKRKWKSVVGLEVHAQIASASKLFSGSGTSFGAPLNSSVAYFDASIPGTLPVLNRKCVESGIKTSLALGCRVNEVSMFDRKHYFYADLPNGYQITQQRAALANDGKMTFPVITPGKKVYYKTAKLLQLQLEQDSGKSLHDDYLKRSLVDLNRAGLPLMELVFAPDLETGEEAASLVKELILILRRLQTCSCKMEEGALRVDANISIHQEGDPLGVRTEVKNIGSVRSISQAITYEINRQLETVANGGVITNETRNWDAENRRTVAMRDKEVLQDYRFMPEPNLPPLHVNLKPGSMSTEDLLSVAALSEEIPELPEDTRQRLVEQHNLNAETAIILVNEPILLDHFLSITRSLSDLPNKVICNFLINDLLTYCNKLNLDVEDCSIKADDLKDILMSLHAELINLQAARQLVDLLHNNPKAKVSELIELHSLQQICSPDEIENLCQLAIANQAKAVEQYQKGKAKALFAIAGEVAKLSSQKANMKLVVQRLEKLLKPTNK", "length": 516 }, "evidence": [ { "id": "O75879", "url": "https://omabrowser.org/oma/group/O75879/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" }, { "name": "carbon-nitrogen ligase activity, with glutamine as amido-N-donor", "id": "GO:0016884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016884", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" }, { "name": "glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity", "id": "GO:0050567", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050567", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" }, { "name": "transferase activity", "id": "GO:0016740", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016740", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "translation", "id": "GO:0006412", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006412", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" }, { "name": "mitochondrial translation", "id": "GO:0032543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032543", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" }, { "name": "glutaminyl-tRNAGln biosynthesis via transamidation", "id": "GO:0070681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070681", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" }, { "name": "glutamyl-tRNA(Gln) amidotransferase complex", "id": "GO:0030956", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030956", "evidence": [ { "database": "UniProtKB", "id": "O75879", "url": "https://www.uniprot.org/uniprot/O75879" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 162, "end_pos": 164, "annotation": "n_glycosylation_sequon" }, { "start_pos": 263, "end_pos": 265, "annotation": "n_glycosylation_sequon" }, { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "17521", "name": "", "equation": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D3ZY68-1", "Q5FWT5-1", "A0A8I6AHE4-1", "O75879-1", "O43716-1", "Q9H0R6-1", "Q8CBY0-1", "Q99JT1-1", "Q9CZN8-1", "P33893-1", "Q03557-1", "P53260-1", "Q54L63-1", "Q54PU2-1", "Q55ER8-1", "Q86BL4-1", "Q9VE09-1", "Q9VCD0-1" ], "evidence": [ { "id": "17521", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/17521" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6AHE4", "gene_name": "Gatb", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "A0A8I6AHE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AHE4" } ] } ] }, { "uniprot_ac": "D3ZY68", "gene_name": "Gatc", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "D3ZY68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZY68" } ] } ] }, { "uniprot_ac": "O43716", "gene_name": "GATC", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "O43716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43716" } ] } ] }, { "uniprot_ac": "O75879", "gene_name": "GATB", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "O75879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75879" } ] } ] }, { "uniprot_ac": "P33893", "gene_name": "PET112", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "P33893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33893" } ] } ] }, { "uniprot_ac": "P53260", "gene_name": "GTF1", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "P53260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53260" } ] } ] }, { "uniprot_ac": "Q03557", "gene_name": "HER2", "activity": [ { "ec_number": "6.3.5.7", "activity": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate.", "evidence": [ { "id": "Q03557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03557" } ] }, { "ec_number": "6.3.5.7", "activity": "", "evidence": [ { "id": "Q03557", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03557" } ] } ] }, { "uniprot_ac": "Q54L63", "gene_name": "gatA", "activity": [ { "ec_number": "6.3.5.7", "activity": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate.", "evidence": [ { "id": "Q54L63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54L63" } ] }, { "ec_number": "6.3.5.7", "activity": "", "evidence": [ { "id": "Q54L63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54L63" } ] } ] }, { "uniprot_ac": "Q54PU2", "gene_name": "gatc", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "Q54PU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54PU2" } ] } ] }, { "uniprot_ac": "Q55ER8", "gene_name": "", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "Q55ER8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55ER8" } ] } ] }, { "uniprot_ac": "Q5FWT5", "gene_name": "Qrsl1", "activity": [ { "ec_number": "6.3.5.7", "activity": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate.", "evidence": [ { "id": "Q5FWT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWT5" } ] }, { "ec_number": "6.3.5.7", "activity": "", "evidence": [ { "id": "Q5FWT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FWT5" } ] } ] }, { "uniprot_ac": "Q86BL4", "gene_name": "GatC", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "Q86BL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BL4" } ] } ] }, { "uniprot_ac": "Q8CBY0", "gene_name": "Gatc", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "Q8CBY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBY0" } ] } ] }, { "uniprot_ac": "Q99JT1", "gene_name": "Gatb", "activity": [ { "ec_number": "6.3.5.-", "activity": "", "evidence": [ { "id": "Q99JT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99JT1" } ] } ] }, { "uniprot_ac": "Q9CZN8", "gene_name": "Qrsl1", "activity": [ { "ec_number": "6.3.5.7", "activity": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate.", "evidence": [ { "id": "Q9CZN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZN8" } ] }, { "ec_number": "6.3.5.7", "activity": "", "evidence": [ { "id": "Q9CZN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CZN8" } ] } ] }, { "uniprot_ac": "Q9H0R6", "gene_name": "QRSL1", "activity": [ { "ec_number": "6.3.5.7", "activity": "ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP 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