{ "uniprot_canonical_ac": "O75865-1", "uniprot_ac": "O75865", "uniprot_id": "TPC6A_HUMAN", "mass": { "chemical_mass": 17605.0, "monoisotopic_mass": 17605.0 }, "refseq": { "ac": "NP_001257820", "name": "trafficking protein particle complex subunit 6A isoform 2", "summary": "This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820" }, "gene_names": [ { "name": "TRAPPC6A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75865", "id": "O75865" }, { "name": "HSPC289", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75865", "id": "O75865" }, { "name": "TRAPPC6A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820", "id": "NP_001257820" }, { "name": "TRS33", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820", "id": "NP_001257820" } ], "protein_names": [ { "name": "Trafficking protein particle complex subunit 6A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75865" }, { "name": "TRAPP complex subunit 6A; trafficking protein particle complex 6A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820", "id": "NP_001257820" }, { "name": "TRAPP complex subunit 6A", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75865" }, { "name": "trafficking protein particle complex subunit 6A isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820", "id": "NP_001257820" } ], "function": [ { "annotation": "Host cellular protein TRAPPC6ADelta interacts with influenza A virus M2 protein and regulates viral propagation by modulating M2 trafficking. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001257820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820" }, { "database": "PubMed", "id": "27795429", "url": "https://glygen.org/publication/PubMed/27795429" } ] }, { "annotation": "Mapping and characterization of mouse Trappc6a, along with a description of the human homolog.", "evidence": [ { "database": "RefSeq", "id": "NP_001257820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820" }, { "database": "PubMed", "id": "16697553", "url": "https://glygen.org/publication/PubMed/16697553" } ] }, { "annotation": "May play a role in vesicular transport during the biogenesis of melanosomes.", "evidence": [ { "database": "UniProtKB", "id": "O75865", "url": "https://www.uniprot.org/uniprot/O75865#function" }, { "database": "UniProtKB", "id": "Q78XR0", "url": "https://www.uniprot.org/uniprot/Q78XR0#function" } ] }, { "annotation": "Missense mutation in TRAPPC6A identified in patients with a neurodevelopmental syndrome, affects stability of the TRAPP complex. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001257820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820" }, { "database": "PubMed", "id": "29391579", "url": "https://glygen.org/publication/PubMed/29391579" } ] }, { "annotation": "This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. Loss of expression of the related gene in mouse affects coat and eye pigmentation, suggesting that the encoded protein may be involved in melanosome biogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_001257820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "88.93", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "79.25", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "82.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "76.5", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "88.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "83.5", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "84.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "86.39", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.14", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "73.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "85.59", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "93.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "90.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000007255", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000007255" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75865", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75865" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", 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ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion.", "journal": "Nature cell biology", "date": "1999", "authors": "Muller JM, Rabouille C, Newman R, Shorter J, Freemont P, Schiavo G, Warren G, Shima DT", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "10559959", "url": "https://glygen.org/publication/PubMed/10559959" } ] }, { "title": "The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo.", "journal": "Molecular biology of the cell", "date": "2000", "authors": "Seemann J, Jokitalo EJ, Warren G", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "10679020", "url": "https://glygen.org/publication/PubMed/10679020" } ] }, { "title": "Asymmetric requirements for a Rab GTPase and 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complexes segregate from COPII in close proximity to ER exit sites.", "journal": "Journal of cell science", "date": "2000", "authors": "Stephens DJ, Lin-Marq N, Pagano A, Pepperkok R, Paccaud JP", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "10825291", "url": "https://glygen.org/publication/PubMed/10825291" } ] }, { "title": "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion.", "journal": "Science (New York, N.Y.)", "date": "2000", "authors": "Allan BB, Moyer BD, Balch WE", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "10903204", "url": "https://glygen.org/publication/PubMed/10903204" } ] }, { "title": "Dynamics of transitional endoplasmic reticulum sites in vertebrate cells.", "journal": "Molecular biology of the cell", "date": "2000", "authors": "Hammond AT, Glick BS", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "10982397", "url": "https://glygen.org/publication/PubMed/10982397" } ] }, { "title": "Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p.", "journal": "The EMBO journal", "date": "2000", "authors": "Siniossoglou S, Peak-Chew SY, Pelham HR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "10990452", "url": "https://glygen.org/publication/PubMed/10990452" } ] }, { "title": "Subunit structure of a mammalian ER/Golgi SNARE complex.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Xu D, Joglekar AP, Williams AL, Hay JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "11035026", "url": "https://glygen.org/publication/PubMed/11035026" } ] }, { "title": "TRAPP stimulates guanine nucleotide exchange on Ypt1p.", "journal": "The Journal of cell biology", "date": "2000", "authors": "Wang W, Sacher M, Ferro-Novick S", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "11038176", "url": "https://glygen.org/publication/PubMed/11038176" } ] }, { "title": "Rab-interacting lysosomal protein (RILP): the Rab7 effector required for transport to lysosomes.", "journal": "The EMBO journal", "date": "2001", "authors": "Cantalupo G, Alifano P, Roberti V, Bruni CB, Bucci C", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ 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"https://glygen.org/publication/PubMed/11689439" } ] }, { "title": "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.", "journal": "Developmental cell", "date": "2001", "authors": "Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "11703925", "url": "https://glygen.org/publication/PubMed/11703925" } ] }, { "title": "Role of rRAB22b, an oligodendrocyte protein, in regulation of transport of vesicles from trans Golgi to endocytic compartments.", "journal": "Journal of neuroscience research", "date": "2001", "authors": "Rodriguez-Gabin AG, Cammer M, Almazan G, Charron M, Larocca JN", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "11746448", "url": "https://glygen.org/publication/PubMed/11746448" } ] }, { "title": "Molecular cloning, bacterial expression and properties of Rab31 and Rab32.", "journal": "European journal of biochemistry", "date": "2002", "authors": "Bao X, Faris AE, Jang EK, Haslam RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "11784320", "url": "https://glygen.org/publication/PubMed/11784320" } ] }, { "title": "Mutation of melanosome protein RAB38 in chocolate mice.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Loftus SK, Larson DM, Baxter LL, Antonellis A, Chen Y, Wu X, Jiang Y, Bittner M, Hammer JA 3rd, Pavan WJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "11917121", "url": "https://glygen.org/publication/PubMed/11917121" } ] }, { "title": "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "11927603", "url": "https://glygen.org/publication/PubMed/11927603" } ] }, { "title": "The small GTPase Rab13 regulates assembly of functional tight junctions in epithelial cells.", "journal": "Molecular biology of the cell", "date": "2002", "authors": "Marzesco AM, Dunia I, Pandjaitan R, Recouvreur M, Dauzonne D, Benedetti EL, Louvard D, Zahraoui A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", 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"reference": [ { "type": "PubMed", "id": "12221131", "url": "https://glygen.org/publication/PubMed/12221131" } ] }, { "title": "Sec16p potentiates the action of COPII proteins to bud transport vesicles.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Supek F, Madden DT, Hamamoto S, Orci L, Schekman R", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "12235121", "url": "https://glygen.org/publication/PubMed/12235121" } ] }, { "title": "Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse.", "journal": "Nature genetics", "date": "2002", "authors": "Kapfhamer D, Valladares O, Sun Y, Nolan PM, Rux JJ, Arnold SE, Veasey SC, Bucan M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": 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"id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "12684051", "url": "https://glygen.org/publication/PubMed/12684051" } ] }, { "title": "Phagosomes fuse with late endosomes and/or lysosomes by extension of membrane protrusions along microtubules: role of Rab7 and RILP.", "journal": "Molecular and cellular biology", "date": "2003", "authors": "Harrison RE, Bucci C, Vieira OV, Schroer TA, Grinstein S", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "12944476", "url": "https://glygen.org/publication/PubMed/12944476" } ] }, { "title": "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.", "journal": "Journal of cell science", "date": "2003", "authors": "Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, Kurosu H, Katada T", "evidence": [ { 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"reference": [ { "type": "PubMed", "id": "15096524", "url": "https://glygen.org/publication/PubMed/15096524" } ] }, { "title": "Rab7 is required for the normal progression of the autophagic pathway in mammalian cells.", "journal": "Journal of cell science", "date": "2004", "authors": "Gutierrez MG, Munafo DB, Beron W, Colombo MI", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15138286", "url": "https://glygen.org/publication/PubMed/15138286" } ] }, { "title": "The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway.", "journal": "Cell", "date": "1992", "authors": "Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, Zerial M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "1516130", "url": 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JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15388334", "url": "https://glygen.org/publication/PubMed/15388334" } ] }, { "title": "Rab13 mediates the continuous endocytic recycling of occludin to the cell surface.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Morimoto S, Nishimura N, Terai T, Manabe S, Yamamoto Y, Shinahara W, Miyake H, Tashiro S, Shimada M, Sasaki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15528189", "url": "https://glygen.org/publication/PubMed/15528189" } ] }, { "title": "A role for the small GTPase Rab21 in the early endocytic pathway.", "journal": "Journal of cell science", "date": "2004", "authors": "Simpson JC, Griffiths G, Wessling-Resnick M, Fransen JA, Bennett H, Jones AT", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15561770", "url": "https://glygen.org/publication/PubMed/15561770" } ] }, { "title": "ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling.", "journal": "The EMBO journal", "date": "2005", "authors": "Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15692570", "url": "https://glygen.org/publication/PubMed/15692570" } ] }, { "title": "Characterization of the human GARP (Golgi associated retrograde protein) complex.", "journal": "Experimental cell research", "date": "2005", "authors": "Liewen H, Meinhold-Heerlein I, Oliveira V, Schwarzenbacher R, Luo G, Wadle A, Jung M, Pfreundschuh M, Stenner-Liewen F", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15878329", "url": "https://glygen.org/publication/PubMed/15878329" } ] }, { "title": "Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane.", "journal": "Journal of cell science", "date": "2005", "authors": "Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H, Fujimoto T", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15914536", "url": "https://glygen.org/publication/PubMed/15914536" } ] }, { "title": "ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2005", "authors": "Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "15958533", "url": "https://glygen.org/publication/PubMed/15958533" } ] }, { "title": "Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Martin S, Driessen K, Nixon SJ, Zerial M, Parton RG", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16207721", "url": "https://glygen.org/publication/PubMed/16207721" } ] }, { "title": "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p.", "journal": "Traffic", "date": "2005", "authors": "Kim MS, Yi MJ, Lee KH, Wagner J, Munger C, Kim YG, Whiteway M, Cygler M, Oh BH, Sacher M", "evidence": [ { "database": "UniProtKB", "id": "O75865", "url": "https://www.uniprot.org/uniprot/O75865" } ], "reference": [ { "type": "PubMed", "id": "16262728", "url": "https://glygen.org/publication/PubMed/16262728" } ] }, { "title": "Cysteine-disulfide cross-linking to monitor SNARE complex assembly during endoplasmic reticulum-Golgi transport.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Flanagan JJ, Barlowe C", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "16303754", "url": "https://glygen.org/publication/PubMed/16303754" } ] }, { "title": "Transcript profiling in peripheral T-cell lymphoma, not otherwise specified, and diffuse large B-cell lymphoma identifies distinct tumor profile signatures.", "journal": "Molecular cancer therapeutics", "date": "2005", "authors": "Mahadevan D, Spier C, Della Croce K, Miller S, George B, Riley C, Warner S, Grogan TM, Miller TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16373702", "url": "https://glygen.org/publication/PubMed/16373702" } ] }, { "title": "Rab5-activating protein 6, a novel endosomal protein with a role in endocytosis.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Hunker CM, Galvis A, Kruk I, Giambini H, Veisaga ML, Barbieri MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16410077", "url": "https://glygen.org/publication/PubMed/16410077" } ] }, { "title": "JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin.", "journal": "Molecular biology of the cell", "date": "2006", "authors": "Terai T, Nishimura N, Kanda I, Yasui N, Sasaki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16525024", "url": "https://glygen.org/publication/PubMed/16525024" } ] }, { "title": "Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics.", "journal": "Journal of cell science", "date": "2006", "authors": "Zhang X, He X, Fu XY, Chang Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16525121", "url": "https://glygen.org/publication/PubMed/16525121" } ] }, { "title": "Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans.", "journal": "Molecular biology of the cell", "date": "2006", "authors": "Mahoney TR, Liu Q, Itoh T, Luo S, Hadwiger G, Vincent R, Wang ZW, Fukuda M, Nonet ML", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16571673", "url": "https://glygen.org/publication/PubMed/16571673" } ] }, { "title": "On and off membrane dynamics of the endoplasmic reticulum-golgi tethering factor p115 in vivo.", "journal": "Molecular biology of the cell", "date": "2006", "authors": "Brandon E, Szul T, Alvarez C, Grabski R, Benjamin R, Kawai R, Sztul E", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "16624868", "url": "https://glygen.org/publication/PubMed/16624868" } ] }, { "title": "Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells.", "journal": "Molecular biology of the cell", "date": "2006", "authors": "Babbey CM, Ahktar N, Wang E, Chen CC, Grant BD, Dunn KW", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16641372", "url": "https://glygen.org/publication/PubMed/16641372" } ] }, { "title": "A mouse TRAPP-related protein is involved in pigmentation.", "journal": "Genomics", "date": "2006", "authors": "Gwynn B, Smith RS, Rowe LB, Taylor BA, Peters LL", "evidence": [ { "database": "RefSeq", "id": "NP_001257820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257820" } ], "reference": [ { "type": "PubMed", "id": "16697553", "url": "https://glygen.org/publication/PubMed/16697553" } ] }, { "title": "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16754960", "url": "https://glygen.org/publication/PubMed/16754960" } ] }, { "title": "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2.", "journal": "J. Mol. Biol.", "date": "2006", "authors": "Kummel D, Muller JJ, Roske Y, Henke N, Heinemann U", "evidence": [ { "database": "UniProtKB", "id": "O75865", "url": "https://www.uniprot.org/uniprot/O75865" } ], "reference": [ { "type": "PubMed", "id": "16828797", "url": "https://glygen.org/publication/PubMed/16828797" } ] }, { "title": "Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Kondo H, Shirakawa R, Higashi T, Kawato M, Fukuda M, Kita T, Horiuchi H", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16880209", "url": "https://glygen.org/publication/PubMed/16880209" } ] }, { "title": "SNAREs--engines for membrane fusion.", "journal": "Nature reviews. Molecular cell biology", "date": "2006", "authors": "Jahn R, Scheller RH", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "16912714", "url": "https://glygen.org/publication/PubMed/16912714" } ] }, { "title": "Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis.", "journal": "Current biology : CB", "date": "2006", "authors": "Kouranti I, Sachse M, Arouche N, Goud B, Echard A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "16950109", "url": "https://glygen.org/publication/PubMed/16950109" } ] }, { "title": "Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2006", "authors": "Watson P, Townley AK, Koka P, Palmer KJ, Stephens DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "17005010", "url": "https://glygen.org/publication/PubMed/17005010" } ] }, { "title": "SNARE status regulates tether recruitment and function in homotypic COPII vesicle fusion.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Bentley M, Liang Y, Mullen K, Xu D, Sztul E, Hay JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "17038314", "url": "https://glygen.org/publication/PubMed/17038314" } ] }, { "title": "Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes.", "journal": "The Journal of cell biology", "date": "2006", "authors": "Wasmeier C, Romao M, Plowright L, Bennett DC, Raposo G, Seabra MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17043139", "url": "https://glygen.org/publication/PubMed/17043139" } ] }, { "title": "Rab10 is involved in basolateral transport in polarized Madin-Darby canine kidney cells.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2007", "authors": "Schuck S, Gerl MJ, Ang A, Manninen A, Keller P, Mellman I, Simons K", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17132146", "url": "https://glygen.org/publication/PubMed/17132146" } ] }, { "title": "Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.", "journal": "Cell metabolism", "date": "2007", "authors": "Lodhi IJ, Chiang SH, Chang L, Vollenweider D, Watson RT, Inoue M, Pessin JE, Saltiel AR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17189207", "url": "https://glygen.org/publication/PubMed/17189207" } ] }, { "title": "Two mammalian Sec16 homologues have nonredundant functions in endoplasmic reticulum (ER) export and transitional ER organization.", "journal": "Molecular biology of the cell", "date": "2007", "authors": "Bhattacharyya D, Glick BS", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "17192411", "url": "https://glygen.org/publication/PubMed/17192411" } ] }, { "title": "Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Ishikura S, Bilan PJ, Klip A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17208202", "url": "https://glygen.org/publication/PubMed/17208202" } ] }, { "title": "ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Suzuki-Utsunomiya K, Hadano S, Otomo A, Kunita R, Mizumura H, Osuga H, Ikeda JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17239822", "url": "https://glygen.org/publication/PubMed/17239822" } ] }, { "title": "TRAPPI tethers COPII vesicles by binding the coat subunit Sec23.", "journal": "Nature", "date": "2007", "authors": "Cai H, Yu S, Menon S, Cai Y, Lazarova D, Fu C, Reinisch K, Hay JC, Ferro-Novick S", "evidence": [ { 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"https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17488286", "url": "https://glygen.org/publication/PubMed/17488286" } ] }, { "title": "Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways.", "journal": "The Journal of cell biology", "date": "2007", "authors": "Fuchs E, Haas AK, Spooner RA, Yoshimura S, Lord JM, Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "17562788", "url": "https://glygen.org/publication/PubMed/17562788" } ] }, { "title": "A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.", "journal": "Cell", "date": "2007", "authors": "Nachury MV, Loktev AV, Zhang Q, Westlake CJ, Peranen J, Merdes A, Slusarski DC, Scheller RH, Bazan JF, Sheffield VC, Jackson PK", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17574030", "url": "https://glygen.org/publication/PubMed/17574030" } ] }, { "title": "Functional dissection of Rab GTPases involved in primary cilium formation.", "journal": "The Journal of cell biology", "date": "2007", "authors": "Yoshimura S, Egerer J, Fuchs E, Haas AK, Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17646400", "url": "https://glygen.org/publication/PubMed/17646400" } ] }, { "title": "Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis.", "journal": "Molecular biology of the cell", "date": "2007", "authors": "Lopes VS, Wasmeier C, Seabra MC, Futter CE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17671165", "url": "https://glygen.org/publication/PubMed/17671165" } ] }, { "title": "Rab22B's role in trans-Golgi network membrane dynamics.", "journal": "Biochemical and biophysical research communications", "date": "2007", "authors": "Ng EL, Wang Y, Tang BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "17678623", "url": "https://glygen.org/publication/PubMed/17678623" } ] }, { "title": "Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells.", "journal": "Journal of cell science", "date": "2007", "authors": "Haas AK, Yoshimura S, Stephens DJ, Preisinger C, Fuchs E, Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "17684057", "url": "https://glygen.org/publication/PubMed/17684057" } ] }, { "title": "Rab10 in insulin-stimulated GLUT4 translocation.", "journal": "The Biochemical journal", "date": "2008", "authors": "Sano H, Roach WG, Peck GR, Fukuda M, Lienhard GE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18076383", "url": "https://glygen.org/publication/PubMed/18076383" } ] }, { "title": "The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.", "journal": "Molecular biology of the cell", "date": "2008", "authors": "Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18094055", "url": "https://glygen.org/publication/PubMed/18094055" } ] }, { "title": "Regulation of endocytic recycling by C. elegans Rab35 and its regulator RME-4, a coated-pit protein.", "journal": "The EMBO journal", "date": "2008", "authors": "Sato M, Sato K, Liou W, Pant S, Harada A, Grant BD", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18354496", "url": "https://glygen.org/publication/PubMed/18354496" } ] }, { "title": "Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.", "journal": "Molecular biology of the cell", "date": "2008", "authors": "Perez-Victoria FJ, Mardones GA, Bonifacino JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18367545", "url": "https://glygen.org/publication/PubMed/18367545" } ] }, { "title": "A small GTP-binding protein dissociates from synaptic vesicles during exocytosis.", "journal": "Nature", "date": "1991", "authors": "Fischer von Mollard G, Sudhof TC, Jahn R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "1845915", "url": "https://glygen.org/publication/PubMed/1845915" } ] }, { "title": "Varp interacts with Rab38 and functions as its potential effector.", "journal": "Biochemical and biophysical research communications", "date": "2008", "authors": "Wang F, Zhang H, Zhang X, Wang Y, Ren F, Zhang X, Zhai Y, Chang Z", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18477474", "url": "https://glygen.org/publication/PubMed/18477474" } ] }, { "title": "Rab3GEP is the non-redundant guanine nucleotide exchange factor for Rab27a in melanocytes.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Figueiredo AC, Wasmeier C, Tarafder AK, Ramalho JS, Baron RA, Seabra MC", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18559336", "url": "https://glygen.org/publication/PubMed/18559336" } ] }, { "title": "The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes.", "journal": "Cell", "date": "2008", "authors": "Cai Y, Chin HF, Lazarova D, Menon S, Fu C, Cai H, Sclafani A, Rodgers DW, De La Cruz EM, Ferro-Novick S, Reinisch KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18585354", "url": "https://glygen.org/publication/PubMed/18585354" } ] }, { "title": "Rab18 and Rab43 have key roles in ER-Golgi trafficking.", "journal": "Journal of cell science", "date": "2008", "authors": "Dejgaard SY, Murshid A, Erman A, Kizilay O, Verbich D, Lodge R, Dejgaard K, Ly-Hartig TB, Pepperkok R, Simpson JC, Presley JF", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18664496", "url": "https://glygen.org/publication/PubMed/18664496" } ] }, { "title": "Muscle cells engage Rab8A and myosin Vb in insulin-dependent GLUT4 translocation.", "journal": "American journal of physiology. Cell physiology", "date": "2008", "authors": "Ishikura S, Klip A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18701652", "url": "https://glygen.org/publication/PubMed/18701652" } ] }, { "title": "Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.", "journal": "The Journal of cell biology", "date": "2008", "authors": "Nokes RL, Fields IC, Collins RN, Folsch H", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18779367", "url": "https://glygen.org/publication/PubMed/18779367" } ] }, { "title": "Integrin trafficking regulated by Rab21 is necessary for cytokinesis.", "journal": "Developmental cell", "date": "2008", "authors": "Pellinen T, Tuomi S, Arjonen A, Wolf M, Edgren H, Meyer H, Grosse R, Kitzing T, Rantala JK, Kallioniemi O, Fassler R, Kallio M, Ivaska J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "18804435", "url": "https://glygen.org/publication/PubMed/18804435" } ] }, { "title": "Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.", "journal": "The EMBO journal", "date": "2008", "authors": "Mancias JD, Goldberg J", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "18843296", "url": "https://glygen.org/publication/PubMed/18843296" } ] }, { "title": "rab5 controls early endosome fusion in vitro.", "journal": "Cell", "date": "1991", "authors": "Gorvel JP, Chavrier P, Zerial M, Gruenberg J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "1900457", "url": "https://glygen.org/publication/PubMed/1900457" } ] }, { "title": "Tracing the retrograde route in protein trafficking.", "journal": "Cell", "date": "2008", "authors": "Johannes L, Popoff V", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19109890", "url": "https://glygen.org/publication/PubMed/19109890" } ] }, { "title": "Membrane fusion: grappling with SNARE and SM proteins.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Sudhof TC, Rothman JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "19164740", "url": "https://glygen.org/publication/PubMed/19164740" } ] }, { "title": "Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31.", "journal": "Experimental cell research", "date": "2009", "authors": "Rodriguez-Gabin AG, Yin X, Si Q, Larocca JN", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19345684", "url": "https://glygen.org/publication/PubMed/19345684" } ] }, { "title": "Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.", "journal": "Molecular biology of the cell", "date": "2009", "authors": "Tamura K, Ohbayashi N, Maruta Y, Kanno E, Itoh T, Fukuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19403694", "url": "https://glygen.org/publication/PubMed/19403694" } ] }, { "title": "TRAPPC2L is a novel, highly conserved TRAPP-interacting protein.", "journal": "Traffic", "date": "2009", "authors": "Scrivens PJ, Shahrzad N, Moores A, Morin A, Brunet S, Sacher M", "evidence": [ { "database": "UniProtKB", "id": "O75865", "url": "https://www.uniprot.org/uniprot/O75865" } ], "reference": [ { "type": "PubMed", "id": "19416478", "url": "https://glygen.org/publication/PubMed/19416478" } ] }, { "title": "RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.", "journal": "Cell", "date": "2009", "authors": "Espinosa EJ, Calero M, Sridevi K, Pfeffer SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19490898", "url": "https://glygen.org/publication/PubMed/19490898" } ] }, { "title": "Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network.", "journal": "Molecular and cellular biology", "date": "2009", "authors": "Perez-Victoria FJ, Bonifacino JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19620288", "url": "https://glygen.org/publication/PubMed/19620288" } ] }, { "title": "Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.", "journal": "Journal of cell science", "date": "2009", "authors": "Hughes H, Budnik A, Schmidt K, Palmer KJ, Mantell J, Noakes C, Johnson A, Carter DA, Verkade P, Watson P, Stephens DJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "19638414", "url": "https://glygen.org/publication/PubMed/19638414" } ] }, { "title": "mTrs130 is a component of a mammalian TRAPPII complex, a Rab1 GEF that binds to COPI-coated vesicles.", "journal": "Molecular biology of the cell", "date": "2009", "authors": "Yamasaki A, Menon S, Yu S, Barrowman J, Meerloo T, Oorschot V, Klumperman J, Satoh A, Ferro-Novick S", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "19656848", "url": "https://glygen.org/publication/PubMed/19656848" } ] }, { "title": "Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.", "journal": "Journal of cellular physiology", "date": "2009", "authors": "Ng EL, Ng JJ, Liang F, Tang BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19725050", "url": "https://glygen.org/publication/PubMed/19725050" } ] }, { "title": "Rab35 controls actin bundling by recruiting fascin as an effector protein.", "journal": "Science (New York, N.Y.)", "date": "2009", "authors": "Zhang J, Fonovic M, Suyama K, Bogyo M, Scott MP", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19729655", "url": "https://glygen.org/publication/PubMed/19729655" } ] }, { "title": "Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth.", "journal": "EMBO reports", "date": "2009", "authors": "Burgo A, Sotirakis E, Simmler MC, Verraes A, Chamot C, Simpson JC, Lanzetti L, Proux-Gillardeaux V, Galli T", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "19745841", "url": "https://glygen.org/publication/PubMed/19745841" } ] }, { "title": "Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2.", "journal": "Molecular and cellular biology", "date": "2010", "authors": "Sakane A, Honda K, Sasaki T", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20008558", "url": "https://glygen.org/publication/PubMed/20008558" } ] }, { "title": "The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.", "journal": "The Journal of biological chemistry", "date": "2010", "authors": "Marat AL, McPherson PS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20154091", "url": "https://glygen.org/publication/PubMed/20154091" } ] }, { "title": "Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.", "journal": "American journal of human genetics", "date": "2010", "authors": "Giannandrea M, Bianchi V, Mignogna ML, Sirri A, Carrabino S, D'Elia E, Vecellio M, Russo S, Cogliati F, Larizza L, Ropers HH, Tzschach A, Kalscheuer V, Oehl-Jaschkowitz B, Skinner C, Schwartz CE, Gecz J, Van Esch H, Raynaud M, Chelly J, de Brouwer AP, Toniolo D, D'Adamo P", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20159109", "url": "https://glygen.org/publication/PubMed/20159109" } ] }, { "title": "The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes.", "journal": "Molecular cell", "date": "2010", "authors": "Allaire PD, Marat AL, Dall'Armi C, Di Paolo G, McPherson PS, Ritter B", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20159556", "url": "https://glygen.org/publication/PubMed/20159556" } ] }, { "title": "Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.", "journal": "Nature", "date": "2010", "authors": "Kinchen JM, Ravichandran KS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20305638", "url": "https://glygen.org/publication/PubMed/20305638" } ] }, { "title": "Coordination of Rab8 and Rab11 in primary ciliogenesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010", "authors": "Knodler A, Feng S, Zhang J, Zhang X, Das A, Peranen J, Guo W", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20308558", "url": "https://glygen.org/publication/PubMed/20308558" } ] }, { "title": "Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C.", "journal": "The Journal of cell biology", "date": "2010", "authors": "Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Gronborg M, Mobius W, Rhee J, Barr FA, Simons M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20404108", "url": "https://glygen.org/publication/PubMed/20404108" } ] }, { "title": "Identification of the switch in early-to-late endosome transition.", "journal": "Cell", "date": "2010", "authors": "Poteryaev D, Datta S, Ackema K, Zerial M, Spang A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20434987", "url": "https://glygen.org/publication/PubMed/20434987" } ] }, { "title": "A targeted siRNA screen to identify SNAREs required for constitutive secretion in mammalian cells.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2010", "authors": "Gordon DE, Bond LM, Sahlender DA, Peden AA", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "20545907", "url": "https://glygen.org/publication/PubMed/20545907" } ] }, { "title": "Junctional adhesion molecule-C is a soluble mediator of angiogenesis.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2010", "authors": "Rabquer BJ, Amin MA, Teegala N, Shaheen MK, Tsou PS, Ruth JH, Lesch CA, Imhof BA, Koch AE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20592283", "url": "https://glygen.org/publication/PubMed/20592283" } ] }, { "title": "p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport.", "journal": "The Journal of cell biology", "date": "2010", "authors": "Ong YS, Tang BL, Loo LS, Hong W", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "20679433", "url": "https://glygen.org/publication/PubMed/20679433" } ] }, { "title": "The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.", "journal": "Current biology : CB", "date": "2010", "authors": "Nordmann M, Cabrera M, Perz A, Brocker C, Ostrowicz C, Engelbrecht-Vandre S, Ungermann C", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20797862", "url": "https://glygen.org/publication/PubMed/20797862" } ] }, { "title": "Rab7: role of its protein interaction cascades in endo-lysosomal traffic.", "journal": "Cellular signalling", "date": "2011", "authors": "Wang T, Ming Z, Xiaochun W, Hong W", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20851765", "url": "https://glygen.org/publication/PubMed/20851765" } ] }, { "title": "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.", "journal": "The Journal of cell biology", "date": "2010", "authors": "Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "20937701", "url": "https://glygen.org/publication/PubMed/20937701" } ] }, { "title": "TRAPP complexes in membrane traffic: convergence through a common Rab.", "journal": "Nature reviews. Molecular cell biology", "date": "2010", "authors": "Barrowman J, Bhandari D, Reinisch K, Ferro-Novick S", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "20966969", "url": "https://glygen.org/publication/PubMed/20966969" } ] }, { "title": "Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2010", "authors": "Sun Y, Bilan PJ, Liu Z, Klip A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21041651", "url": "https://glygen.org/publication/PubMed/21041651" } ] }, { "title": "Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments.", "journal": "Cell", "date": "1990", "authors": "Chavrier P, Parton RG, Hauri HP, Simons K, Zerial M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "2115402", "url": "https://glygen.org/publication/PubMed/2115402" } ] }, { "title": "Transport according to GARP: receiving retrograde cargo at the trans-Golgi network.", "journal": "Trends in cell biology", "date": "2011", "authors": "Bonifacino JS, Hierro A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21183348", "url": "https://glygen.org/publication/PubMed/21183348" } ] }, { "title": "Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Tamura K, Ohbayashi N, Ishibashi K, Fukuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21187289", "url": "https://glygen.org/publication/PubMed/21187289" } ] }, { "title": "Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis.", "journal": "Trends in endocrinology and metabolism: TEM", "date": "2011", "authors": "Hoffman NJ, Elmendorf JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21216617", "url": "https://glygen.org/publication/PubMed/21216617" } ] }, { "title": "Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Westlake CJ, Baye LM, Nachury MV, Wright KJ, Ervin KE, Phu L, Chalouni C, Beck JS, Kirkpatrick DS, Slusarski DC, Sheffield VC, Scheller RH, Jackson PK", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21273506", "url": "https://glygen.org/publication/PubMed/21273506" } ] }, { "title": "DENN domain proteins: regulators of Rab GTPases.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Marat AL, Dokainish H, McPherson PS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21330364", "url": "https://glygen.org/publication/PubMed/21330364" } ] }, { "title": "Entry at the trans-face of the Golgi.", "journal": "Cold Spring Harbor perspectives in biology", "date": "2011", "authors": "Pfeffer SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21421921", "url": "https://glygen.org/publication/PubMed/21421921" } ] }, { "title": "A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis.", "journal": "PLoS biology", "date": "2011", "authors": "Taylor MJ, Perrais D, Merrifield CJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21445324", "url": "https://glygen.org/publication/PubMed/21445324" } ] }, { "title": "Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins.", "journal": "Cell", "date": "2011", "authors": "Uytterhoeven V, Kuenen S, Kasprowicz J, Miskiewicz K, Verstreken P", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21458671", "url": "https://glygen.org/publication/PubMed/21458671" } ] }, { "title": "TFG-1 function in protein secretion and oncogenesis.", "journal": "Nature cell biology", "date": "2011", "authors": "Witte K, Schuh AL, Hegermann J, Sarkeshik A, Mayers JR, Schwarze K, Yates JR 3rd, Eimer S, Audhya A", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "21478858", "url": "https://glygen.org/publication/PubMed/21478858" } ] }, { "title": "Sequential interactions with Sec23 control the direction of vesicle traffic.", "journal": "Nature", "date": "2011", "authors": "Lord C, Bhandari D, Menon S, Ghassemian M, Nycz D, Hay J, Ghosh P, Ferro-Novick S", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": 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"database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21586568", "url": "https://glygen.org/publication/PubMed/21586568" } ] }, { "title": "Membrane dynamics and fusion at late endosomes and vacuoles--Rab regulation, multisubunit tethering complexes and SNAREs.", "journal": "European journal of cell biology", "date": "2011", "authors": "Epp N, Rethmeier R, Kramer L, Ungermann C", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21683469", "url": "https://glygen.org/publication/PubMed/21683469" } ] }, { "title": "Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF).", "journal": "Biochimica et biophysica acta", "date": "2012", "authors": "Zhao C, Smith EC, Whiteheart SW", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "21689688", "url": "https://glygen.org/publication/PubMed/21689688" } ] }, { "title": "Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.", "journal": "Nature cell biology", "date": "2011", "authors": "Dambournet D, Machicoane M, Chesneau L, Sachse M, Rocancourt M, El Marjou A, Formstecher E, Salomon R, Goud B, Echard A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21706022", "url": "https://glygen.org/publication/PubMed/21706022" } ] }, { "title": "Small GTPase Rab12 regulates constitutive degradation of transferrin receptor.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2011", "authors": "Matsui T, Itoh T, Fukuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21718402", "url": "https://glygen.org/publication/PubMed/21718402" } ] }, { "title": "Distinct yet overlapping roles of Rab GTPases on synaptic vesicles.", "journal": "Small GTPases", "date": "2011", "authors": "Pavlos NJ, Jahn R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21776405", "url": "https://glygen.org/publication/PubMed/21776405" } ] }, { "title": "MICAL-L1 is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2012", "authors": "Rahajeng J, Giridharan SS, Cai B, Naslavsky N, Caplan S", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "21951725", "url": "https://glygen.org/publication/PubMed/21951725" } ] }, { "title": "COPII and COPI traffic at the ER-Golgi interface.", "journal": "Physiology (Bethesda, Md.)", "date": "2011", "authors": "Szul T, Sztul E", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "22013193", "url": "https://glygen.org/publication/PubMed/22013193" } ] }, { "title": "Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Wu X, Bradley MJ, Cai Y, Kummel D, De La Cruz EM, Barr FA, Reinisch KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22065758", "url": "https://glygen.org/publication/PubMed/22065758" } ] }, { "title": "Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton.", "journal": "Molecular biology of the cell", "date": "2012", "authors": "Marat AL, Ioannou MS, McPherson PS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22072793", "url": "https://glygen.org/publication/PubMed/22072793" } ] }, { "title": "Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat.", "journal": "The EMBO journal", "date": "2012", "authors": "Kung LF, Pagant S, Futai E, D'Arcangelo JG, Buchanan R, Dittmar JC, Reid RJ, Rothstein R, Hamamoto S, Snapp EL, Schekman R, Miller EA", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "22157747", "url": "https://glygen.org/publication/PubMed/22157747" } ] }, { "title": "The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes.", "journal": "Molecular biology of the cell", "date": "2012", "authors": "Ohbayashi N, Yatsu A, Tamura K, Fukuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22171327", "url": "https://glygen.org/publication/PubMed/22171327" } ] }, { "title": "Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression.", "journal": "Molecular cell", "date": "2012", "authors": "Kachaner D, Filipe J, Laplantine E, Bauch A, Bennett KL, Superti-Furga G, Israel A, Weil R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22365832", "url": "https://glygen.org/publication/PubMed/22365832" } ] }, { "title": "A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Feng S, Knodler A, Ren J, Zhang J, Zhang X, Hong Y, Huang S, Peranen J, Guo W", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22433857", "url": "https://glygen.org/publication/PubMed/22433857" } ] }, { "title": "BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles.", "journal": "The Journal of biological chemistry", "date": "2012", "authors": "Bultema JJ, Ambrosio AL, Burek CL, Di Pietro SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22511774", "url": "https://glygen.org/publication/PubMed/22511774" } ] }, { "title": "Are Rab proteins the link between Golgi organization and membrane trafficking?", "journal": "Cellular and molecular life sciences : CMLS", "date": "2012", "authors": "Liu S, Storrie B", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22581368", "url": "https://glygen.org/publication/PubMed/22581368" } ] }, { "title": "Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells.", "journal": "Developmental cell", "date": "2012", "authors": "Linford A, Yoshimura S, Nunes Bastos R, Langemeyer L, Gerondopoulos A, Rigden DJ, Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22595670", "url": "https://glygen.org/publication/PubMed/22595670" } ] }, { "title": "Rab5 is necessary for the biogenesis of the endolysosomal system in vivo.", "journal": "Nature", "date": "2012", "authors": "Zeigerer A, Gilleron J, Bogorad RL, Marsico G, Nonaka H, Seifert S, Epstein-Barash H, Kuchimanchi S, Peng CG, Ruda VM, Del Conte-Zerial P, Hengstler JG, Kalaidzidis Y, Koteliansky V, Zerial M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22622570", "url": "https://glygen.org/publication/PubMed/22622570" } ] }, { "title": "Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.", "journal": "Molecular biology of the cell", "date": "2012", "authors": "Jean S, Cox S, Schmidt EJ, Robinson FL, Kiger A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22648168", "url": "https://glygen.org/publication/PubMed/22648168" } ] }, { "title": "The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization.", "journal": "EMBO reports", "date": "2012", "authors": "Reiter JF, Blacque OE, Leroux MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "22653444", "url": "https://glygen.org/publication/PubMed/22653444" } ] }, { "title": "Insights into structural and regulatory roles of Sec16 in COPII vesicle formation at ER exit sites.", "journal": "Molecular biology of the cell", "date": "2012", "authors": "Yorimitsu T, Sato K", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": 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RAB12-mediated autophagic death in retinal ganglion cells.", "journal": "Autophagy", "date": "2013", "authors": "Sirohi K, Chalasani ML, Sudhakar C, Kumari A, Radha V, Swarup G", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23357852", "url": "https://glygen.org/publication/PubMed/23357852" } ] }, { "title": "The highly conserved COPII coat complex sorts cargo from the endoplasmic reticulum and targets it to the golgi.", "journal": "Cold Spring Harbor perspectives in biology", "date": "2013", "authors": "Lord C, Ferro-Novick S, Miller EA", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "23378591", "url": "https://glygen.org/publication/PubMed/23378591" } ] }, { "title": "Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome.", "journal": "Human mutation", "date": "2013", "authors": "Handley MT, Morris-Rosendahl DJ, Brown S, Macdonald F, Hardy C, Bem D, Carpanini SM, Borck G, Martorell L, Izzi C, Faravelli F, Accorsi P, Pinelli L, Basel-Vanagaite L, Peretz G, Abdel-Salam GM, Zaki MS, Jansen A, Mowat D, Glass I, Stewart H, Mancini G, Lederer D, Roscioli T, Giuliano F, Plomp AS, Rolfs A, Graham JM, Seemanova E, Poo P, Garcia-Cazorla A, Edery P, Jackson IJ, Maher ER, Aligianis IA", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23420520", "url": "https://glygen.org/publication/PubMed/23420520" } ] }, { "title": "A role for Rab14 in the endocytic trafficking of GLUT4 in 3T3-L1 adipocytes.", "journal": "Journal of cell science", "date": "2013", "authors": "Reed SE, Hodgson LR, Song S, May MT, Kelly EE, McCaffrey MW, Mastick CC, Verkade P, Tavare JM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23444368", "url": "https://glygen.org/publication/PubMed/23444368" } ] }, { "title": "Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4.", "journal": "EMBO reports", "date": "2013", "authors": "Matsui T, Fukuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23478338", "url": "https://glygen.org/publication/PubMed/23478338" } ] }, { "title": "Inhibition of TFG function causes hereditary axon degeneration by impairing endoplasmic reticulum structure.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2013", "authors": "Beetz C, Johnson A, Schuh AL, Thakur S, Varga RE, Fothergill T, Hertel N, Bomba-Warczak E, Thiele H, Nurnberg G, Altmuller J, Saxena R, Chapman ER, Dent EW, Nurnberg P, Audhya A", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "23479643", "url": "https://glygen.org/publication/PubMed/23479643" } ] }, { "title": "CORVET and HOPS tethering complexes - coordinators of endosome and lysosome fusion.", "journal": "Journal of cell science", "date": "2013", "authors": "Balderhaar HJ, Ungermann C", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23645161", "url": "https://glygen.org/publication/PubMed/23645161" } ] }, { "title": "Rab27 effectors, pleiotropic regulators in secretory pathways.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2013", "authors": "Fukuda M", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23678941", "url": "https://glygen.org/publication/PubMed/23678941" } ] }, { "title": "Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.", "journal": "Cell metabolism", "date": "2013", "authors": "Humphrey SJ, Yang G, Yang P, Fazakerley DJ, Stockli J, Yang JY, James DE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23684622", "url": "https://glygen.org/publication/PubMed/23684622" } ] }, { "title": "Organization of the ER-Golgi interface for membrane traffic control.", "journal": "Nature reviews. Molecular cell biology", "date": "2013", "authors": "Brandizzi F, Barlowe C", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "23698585", "url": "https://glygen.org/publication/PubMed/23698585" } ] }, { "title": "Rab10 delivers GLUT4 storage vesicles to the plasma membrane.", "journal": "Communicative & integrative biology", "date": "2013", "authors": "Chen Y, Lippincott-Schwartz J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "23713133", "url": "https://glygen.org/publication/PubMed/23713133" } ] }, { "title": "The Golgi puppet master: COG complex at center stage of membrane trafficking interactions.", "journal": "Histochemistry and cell biology", "date": "2013", "authors": "Willett R, Ungar D, Lupashin V", "evidence": [ { "database": 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"https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "24119662", "url": "https://glygen.org/publication/PubMed/24119662" } ] }, { "title": "The roles of evolutionarily conserved functional modules in cilia-related trafficking.", "journal": "Nature cell biology", "date": "2013", "authors": "Sung CH, Leroux MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8876198" } ], "reference": [ { "type": "PubMed", "id": "24296415", "url": "https://glygen.org/publication/PubMed/24296415" } ] }, { "title": "Engagement of the small GTPase Rab31 protein and its effector, early endosome antigen 1, is important for trafficking of the ligand-bound epidermal growth factor receptor from the early to the late endosome.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Chua CE, Tang BL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8876198", "url": 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"Johnson A, Bhattacharya N, Hanna M, Pennington JG, Schuh AL, Wang L, Otegui MS, Stagg SM, Audhya A", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "25586378", "url": "https://glygen.org/publication/PubMed/25586378" } ] }, { "title": "SEC16 in COPII coat dynamics at ER exit sites.", "journal": "Biochemical Society transactions", "date": "2015", "authors": "Sprangers J, Rabouille C", "evidence": [ { "database": "Reactome", "id": "R-HSA-204005", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-204005" } ], "reference": [ { "type": "PubMed", "id": "25619252", "url": "https://glygen.org/publication/PubMed/25619252" } ] }, { "title": "Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.", "journal": "EMBO reports", "date": "2015", "authors": "Jean S, Cox S, Nassari S, Kiger AA", "evidence": [ { "database": 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