{ "uniprot_canonical_ac": "O75807-1", "uniprot_ac": "O75807", "uniprot_id": "PR15A_HUMAN", "mass": { "chemical_mass": 73478.0, "monoisotopic_mass": 73478.0 }, "refseq": { "ac": "NP_055145", "name": "protein phosphatase 1 regulatory subunit 15A", "summary": "This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" }, "gene_names": [ { "name": "PPP1R15A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75807", "id": "O75807" }, { "name": "GADD34", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145", "id": "NP_055145" }, { "name": "GADD34", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75807", "id": "O75807" }, { "name": "PPP1R15A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145", "id": "NP_055145" } ], "protein_names": [ { "name": "Protein phosphatase 1 regulatory subunit 15A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75807" }, { "name": "Growth arrest and DNA damage-inducible protein GADD34", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75807" }, { "name": "Myeloid differentiation primary response protein MyD116 homolog", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75807" }, { "name": "growth arrest and DNA-damage-inducible 34; growth arrest and DNA damage-inducible protein GADD34; myeloid differentiation primary response protein MyD116 homolog; protein phosphatase 1, regulatory (inhibitor) subunit 15A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145", "id": "NP_055145" }, { "name": "protein phosphatase 1 regulatory subunit 15A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145", "id": "NP_055145" } ], "function": [ { "annotation": "(Microbial infection) Promotes enterovirus 71 replication by mediating the internal ribosome entry site (IRES) activity of viral 5'-UTR.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807#function" }, { "database": "PubMed", "id": "34985336", "url": "https://glygen.org/publication/PubMed/34985336" } ] }, { "annotation": "Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.", "evidence": [ { "database": "RefSeq", "id": "NP_055145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" }, { "database": "PubMed", "id": "34985336", "url": "https://glygen.org/publication/PubMed/34985336" } ] }, { "annotation": "GADD34 translation is regulated by a unique 5'UTR uORF mechanism to ensure proper GADD34 expression during eIF2alpha phosphorylation", "evidence": [ { "database": "RefSeq", "id": "NP_055145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" }, { "database": "PubMed", "id": "19131336", "url": "https://glygen.org/publication/PubMed/19131336" } ] }, { "annotation": "Higher-order phosphatase-substrate contacts terminate the integrated stress response.", "evidence": [ { "database": "RefSeq", "id": "NP_055145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" }, { "database": "PubMed", "id": "34625748", "url": "https://glygen.org/publication/PubMed/34625748" } ] }, { "annotation": "Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26742780, PubMed:26095357). Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1 (PubMed:14718519). May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15' (PubMed:14635196). Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux (PubMed:32978159). Acts also a viral restriction factor by attenuating HIV-1 replication (PubMed:31778897). Mechanistically, mediates the inhibition of HIV-1 TAR RNA-mediated translation (PubMed:31778897).", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807#function" }, { "database": "PubMed", "id": "14635196", "url": "https://glygen.org/publication/PubMed/14635196" }, { "database": "PubMed", "id": "14718519", "url": "https://glygen.org/publication/PubMed/14718519" }, { "database": "PubMed", "id": "11564868", "url": "https://glygen.org/publication/PubMed/11564868" }, { "database": "PubMed", "id": "26095357", "url": "https://glygen.org/publication/PubMed/26095357" }, { "database": "PubMed", "id": "31778897", "url": "https://glygen.org/publication/PubMed/31778897" }, { "database": "PubMed", "id": "8139541", "url": "https://glygen.org/publication/PubMed/8139541" }, { "database": "PubMed", "id": "12556489", "url": "https://glygen.org/publication/PubMed/12556489" } ] }, { "annotation": "Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" }, { "database": "PubMed", "id": "34732748", "url": "https://glygen.org/publication/PubMed/34732748" } ] }, { "annotation": "Substrate recognition determinants of human eIF2alpha phosphatases.", "evidence": [ { "database": "RefSeq", "id": "NP_055145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" }, { "database": "PubMed", "id": "34847777", "url": "https://glygen.org/publication/PubMed/34847777" } ] }, { "annotation": "The PPP1R15 Family of eIF2-alpha Phosphatase Targeting Subunits (GADD34 and CReP). Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" }, { "database": "PubMed", "id": "38139150", "url": "https://glygen.org/publication/PubMed/38139150" } ] }, { "annotation": "This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_055145", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055145" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 25, "end_pos": 25, "sequence_org": "V", "sequence_mut": "R", "comment": "Localizes to cytoplasm, degraded more slowly.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "21518769", "url": "https://glygen.org/publication/PubMed/21518769" } ] }, { "start_pos": 262, "end_pos": 262, "sequence_org": "Y", "sequence_mut": "F", "comment": "Significantly reduced turnover.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "24092754", "url": "https://glygen.org/publication/PubMed/24092754" } ] }, { "start_pos": 29, "end_pos": 29, "sequence_org": "L", "sequence_mut": "R", "comment": "Localizes to cytoplasm.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "21518769", "url": "https://glygen.org/publication/PubMed/21518769" } ] }, { "start_pos": 555, "end_pos": 558, "sequence_org": "KVRF", "sequence_mut": "AAAA", "comment": "Reduces interaction with SMARCB1.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "12016208", "url": "https://glygen.org/publication/PubMed/12016208" } ] }, { "start_pos": 556, "end_pos": 558, "sequence_org": "VRF", "sequence_mut": "ARA", "comment": "Impairs PP1 activation.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "12556489", "url": "https://glygen.org/publication/PubMed/12556489" } ] }, { "start_pos": 612, "end_pos": 612, "sequence_org": "R", "sequence_mut": "K", "comment": "Reduces PP1-binding; when associated with K-614.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "12556489", "url": "https://glygen.org/publication/PubMed/12556489" } ] }, { "start_pos": 614, "end_pos": 614, "sequence_org": "R", "sequence_mut": "K", "comment": "Reduces PP1-binding; when associated with K-612.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "12556489", "url": "https://glygen.org/publication/PubMed/12556489" } ] }, { "start_pos": 618, "end_pos": 618, "sequence_org": "R", "sequence_mut": "D", "comment": "Reduces PP1-binding.", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "12556489", "url": "https://glygen.org/publication/PubMed/12556489" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "82.52", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "77.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "81.59", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "75.52", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "97.96", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "93.5", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "65.8", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "83.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "91.25", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "91.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "83.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "93.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000087074", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000087074" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75807" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has 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"id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O75807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75807" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O75807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75807" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O75807", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75807" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75807" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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{ "id": "A0A994J4D6-1", "url": "https://www.uniprot.org/uniprot/A0A994J4D6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J786", "url": "https://www.uniprot.org/uniprot/A0A994J786", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A994J786-1", "url": "https://www.uniprot.org/uniprot/A0A994J786-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QXL1", "url": "https://www.uniprot.org/uniprot/M0QXL1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0QXL1-1", "url": "https://www.uniprot.org/uniprot/M0QXL1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75807-1", "url": "https://www.uniprot.org/uniprot/O75807-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75807-2", "url": "https://www.uniprot.org/uniprot/O75807-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG", "length": 674, "header": "sp|O75807-1|PR15A_HUMAN Isoform 1 of Protein phosphatase 1 regulatory subunit 15A OS=Homo sapiens OX=9606 GN=PPP1R15A PE=1 SV=1 CANONICAL=O75807-1" }, "isoforms": [ { "isoform_ac": "A0A994J4D6-1", "url": "", "sequence": { "sequence": "MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG", "length": 579, "header": "tr|A0A994J4D6-1|PR15A_HUMAN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 15A OS=Homo sapiens OX=9606 GN=PPP1R15A PE=1 SV=1 CANONICAL=O75807-1" }, "locus": { "chromosome": "19", "start_pos": 48875970, "end_pos": 48873234, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704026.1", "url": "https://www.ensembl.org/id/ENST00000704026.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515636.1", "url": "https://www.ensembl.org/id/ENSP00000515636.1" } ] } }, { "isoform_ac": "A0A994J786-1", "url": "", "sequence": { "sequence": "MAPKLYFFLPLFQPRHMAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG", "length": 690, "header": "tr|A0A994J786-1|PR15A_HUMAN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 15A OS=Homo sapiens OX=9606 GN=PPP1R15A PE=1 SV=1 CANONICAL=O75807-1" }, "locus": { "chromosome": "19", "start_pos": 48875970, "end_pos": 48873186, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000704027.1", "url": "https://www.ensembl.org/id/ENST00000704027.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000515637.1", "url": "https://www.ensembl.org/id/ENSP00000515637.1" } ] } }, { "isoform_ac": "M0QXL1-1", "url": "", "sequence": { "sequence": "MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVGAESPDSIFFFFLIELESWAVTQAGVQRHDLGSLPTSAAQVQAILVPQPPEYLGLQAHDTTPS", "length": 619, "header": "tr|M0QXL1-1|M0QXL1_HUMAN Computationally mapped isoform of Protein phosphatase 1 regulatory subunit 15A OS=Homo sapiens OX=9606 GN=PPP1R15A PE=1 SV=2 CANONICAL=O75807-1" }, "locus": { "chromosome": "19", "start_pos": 48875090, "end_pos": 48873234, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000600406.2", "url": "https://www.ensembl.org/id/ENST00000600406.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000469239.2", "url": "https://www.ensembl.org/id/ENSP00000469239.2" } ] } }, { "isoform_ac": "O75807-1", "url": "", "sequence": { "sequence": "MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG", "length": 674, "header": "sp|O75807-1|PR15A_HUMAN Isoform 1 of Protein phosphatase 1 regulatory subunit 15A OS=Homo sapiens OX=9606 GN=PPP1R15A PE=1 SV=1 CANONICAL=O75807-1" }, "locus": { "chromosome": "19", "start_pos": 48875970, "end_pos": 48873234, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000200453.6", "url": "https://www.ensembl.org/id/ENST00000200453.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000200453.4", "url": "https://www.ensembl.org/id/ENSP00000200453.4" } ] } }, { "isoform_ac": "O75807-2", "url": "", "sequence": { "sequence": "MAPGQAPHQATPWRDDKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG", "length": 515, "header": "sp|O75807-2|PR15A_HUMAN Isoform 2 of Protein phosphatase 1 regulatory subunit 15A OS=Homo sapiens OX=9606 GN=PPP1R15A PE=1 SV=1 CANONICAL=O75807-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 143, "end_pos": 143, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O75807", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75807" } ], "site_lbl": "Ser143" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "24092754", "url": "https://glygen.org/publication/PubMed/24092754" }, { "database": "iPTMnet", "id": "O75807", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75807" }, { "database": "PubMed", "id": "17287340", "url": "https://glygen.org/publication/PubMed/17287340" } ], "site_lbl": "Tyr262" }, { "start_pos": 264, "end_pos": 264, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75807", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75807" }, { "database": "PubMed", "id": "17287340", "url": "https://glygen.org/publication/PubMed/17287340" } ], "site_lbl": "Ser264" }, { "start_pos": 391, "end_pos": 391, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "24092754", "url": "https://glygen.org/publication/PubMed/24092754" }, { "database": "iPTMnet", "id": "O75807", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75807" } ], "site_lbl": "Tyr391" }, { "start_pos": 434, "end_pos": 434, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "24092754", "url": "https://glygen.org/publication/PubMed/24092754" }, { "database": "iPTMnet", "id": "O75807", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75807" } ], "site_lbl": "Tyr434" }, { "start_pos": 512, "end_pos": 512, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "PubMed", "id": "24092754", "url": "https://glygen.org/publication/PubMed/24092754" }, { "database": "iPTMnet", "id": "O75807", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75807" } ], "site_lbl": "Tyr512" }, { "start_pos": 559, "end_pos": 559, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75807", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75807" }, { "database": "PubMed", "id": "35494241", "url": "" } ], "site_lbl": "Ser559" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins.", "journal": "Mol. Cell. Biol.", "date": "1999", "authors": "Adler HT, Chinery R, Wu DY, Kussick SJ, Payne JM, Fornace AJ Jr, Tkachuk DC", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" } ], "reference": [ { "type": "PubMed", "id": "10490642", "url": "https://glygen.org/publication/PubMed/10490642" } ] }, { "title": "Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.", "journal": "Nature", "date": "1999", "authors": "Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "10519551", "url": "https://glygen.org/publication/PubMed/10519551" } ] }, { "title": "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Datta PK, Moses HL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "10757800", "url": "https://glygen.org/publication/PubMed/10757800" } ] }, { "title": "Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter.", "journal": "Molecular and cellular biology", "date": "2000", "authors": "Bruhat A, Jousse C, Carraro V, Reimold AM, Ferrara M, Fafournoux P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "10982836", "url": "https://glygen.org/publication/PubMed/10982836" } ] }, { "title": "Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Zhang Y, Chang C, Gehling DJ, Hemmati-Brivanlou A, Derynck R", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "11158580", "url": "https://glygen.org/publication/PubMed/11158580" } ] }, { "title": "Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.", "journal": "Molecular cell", "date": "2000", "authors": "Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "11163210", "url": "https://glygen.org/publication/PubMed/11163210" } ] }, { "title": "Peroxynitrite induces GADD34, 45, and 153 VIA p38 MAPK in human neuroblastoma SH-SY5Y cells.", "journal": "Free radical biology & medicine", "date": "2001", "authors": "Oh-Hashi K, Maruyama W, Isobe K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "11163539", "url": "https://glygen.org/publication/PubMed/11163539" } ] }, { "title": "Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors.", "journal": "International journal of cancer", "date": "2001", "authors": "Hollander MC, Sheikh MS, Yu K, Zhan Q, Iglesias M, Woodworth C, Fornace AJ Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "11241327", "url": "https://glygen.org/publication/PubMed/11241327" } ] }, { "title": "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Ebisawa T, Fukuchi M, Murakami G, Chiba T, Tanaka K, Imamura T, Miyazono K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "11278251", "url": "https://glygen.org/publication/PubMed/11278251" } ] }, { "title": "Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Grishin AV, Azhipa O, Semenov I, Corey SJ", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" } ], "reference": [ { "type": "PubMed", "id": "11517336", "url": "https://glygen.org/publication/PubMed/11517336" } ] }, { "title": "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" } ], "reference": [ { "type": "PubMed", "id": "11564868", "url": "https://glygen.org/publication/PubMed/11564868" } ] }, { "title": "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Wu DY, Tkachuck DC, Roberson RS, Schubach WH", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" } ], "reference": [ { "type": "PubMed", "id": "12016208", "url": "https://glygen.org/publication/PubMed/12016208" } ] }, { "title": "mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.", "journal": "Proc. Natl. Acad. Sci. 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Biol. Chem.", "date": "1997", "authors": "Hollander MC, Zhan Q, Bae I, Fornace AJ Jr", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" }, { "database": "Reactome", "id": "R-HSA-9648895", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895" } ], "reference": [ { "type": "PubMed", "id": "9153226", "url": "https://glygen.org/publication/PubMed/9153226" } ] }, { "title": "The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.", "journal": "Cell", "date": "1997", "authors": "Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, Falb D", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "9215638", "url": "https://glygen.org/publication/PubMed/9215638" } ] }, { "title": "Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.", "journal": "Nature", "date": "1997", "authors": "Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "9335507", "url": "https://glygen.org/publication/PubMed/9335507" } ] }, { "title": "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Datta PK, Chytil A, Gorska AE, Moses HL", "evidence": [ { "database": "Reactome", "id": "R-HSA-2173788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788" } ], "reference": [ { "type": "PubMed", "id": "9856985", "url": "https://glygen.org/publication/PubMed/9856985" } ] } ], "pathway": [ { "id": "hsa:23645", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23645", "resource": "KEGG Pathway" }, { "id": "R-HSA-2173788", "name": "Downregulation of TGF-beta receptor signaling", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2173788", "resource": "Reactome", "description": "Downregulation of TGF-beta receptor signaling" }, { "id": "R-HSA-9648895", "name": "Response of EIF2AK1 (HRI) to heme deficiency", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648895", "resource": "Reactome", "description": "Response of EIF2AK1 (HRI) to heme deficiency" } ], "orthologs": [ { "uniprot_canonical_ac": "P17564-1", "protein_name": "Protein phosphatase 1 regulatory subunit 15A", "gene_name": "Ppp1r15a", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAPSPRPQHVLHWRDAHNFYLLSPLMGLLSRAWSRLRGPEVPEAWLAKTVTGADQIEAAALLTPTPVSGNLLPHGETEESGSPEQSQAAQRLCLVEAESSPPETWGLSNVDEYNAKPGQDDLREKEMERTAGKATLQPAGLQGADKRLGEVVAREEGVAEPAYPTSQLEGGPAENEEDGETVKTYQASAASIAPGYKPSTPVPFLGEAEHQATEEKGTENKADPSNSPSSGSHSRAWEYYSREKPKQEGEAKVEAHRAGQGHPCRNAEAEEGGPETTFVCTGNAFLKAWVYRPGEDTEEEDNSDSDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEEDSDSDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEENSDLDSAEEDTAQTGATPHTSAFLKAWVYRPGEDTEEENSDLDSAEEDTAQTGATPHTSPFLKAWVYRPGEDTEDDTEEEEDSENVAPGDSETADSSQSPCLQPQRCLPGEKTKGRGEEPPLFQVAFYLPGEKPESPWAAPKLPLRLQRRLRLFKAPTRDQDPEIPLKARKVHFAEKVTVHFLAVWAGPAQAARRGPWEQFARDRSRFARRIAQAEEKLGPYLTPDSRARAWARLRNPSLPQSEPRSSSEATPLTQDVTTPSPLPSETPSPSLYLGGRRG", "length": 657 }, "evidence": [ { "id": "45930648", "url": "http://www.informatics.jax.org/homology/45930648", "database": "MGI" }, { "id": "O75807", "url": "https://omabrowser.org/oma/group/O75807/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q6IN02-1", "protein_name": "Protein phosphatase 1 regulatory 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"" }, { "name": "protein phosphatase 1 binding", "id": "GO:0008157", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008157", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" } ], "pmid": "" }, { "name": "protein phosphatase activator activity", "id": "GO:0072542", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072542", "evidence": [ { "database": "UniProtKB", "id": "O75807", "url": "https://www.uniprot.org/uniprot/O75807" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [ { "annotation": "Phosphorylated at multiple Ser/Thr residues. 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