{ "uniprot_canonical_ac": "O75717-1", "uniprot_ac": "O75717", "uniprot_id": "WDHD1_HUMAN", "mass": { "chemical_mass": 125967.0, "monoisotopic_mass": 125967.0 }, "refseq": { "ac": "NP_001008397", "name": "WD repeat and HMG-box DNA-binding protein 1 isoform 2", "summary": "The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, "gene_names": [ { "name": "WDHD1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75717", "id": "O75717" }, { "name": "AND-1; AND1; CHTF4; CTF4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397", "id": "NP_001008397" }, { "name": "AND1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75717", "id": "O75717" }, { "name": "WDHD1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397", "id": "NP_001008397" } ], "protein_names": [ { "name": "WD repeat and HMG-box DNA-binding protein 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75717" }, { "name": "Acidic nucleoplasmic DNA-binding protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75717" }, { "name": "And-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75717" }, { "name": "CTF4, chromosome transmission fidelity factor 4 homolog; Acidic nucleoplasmic DNA-binding protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397", "id": "NP_001008397" }, { "name": "WD repeat and HMG-box DNA-binding protein 1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397", "id": "NP_001008397" } ], "function": [ { "annotation": "Core replisome component that acts as a replication initiation factor. Binds directly to the CMG complex and functions as a hub to recruit additional proteins to the replication fork.", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717#function" }, { "database": "PubMed", "id": "19805216", "url": "https://glygen.org/publication/PubMed/19805216" }, { "database": "PubMed", "id": "34694004", "url": "https://glygen.org/publication/PubMed/34694004" }, { "database": "PubMed", "id": "35585232", "url": "https://glygen.org/publication/PubMed/35585232" } ] }, { "annotation": "Mcm10 is required for chromatin loading of And-1.", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, { "database": "PubMed", "id": "17761813", "url": "https://glygen.org/publication/PubMed/17761813" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, { "database": "PubMed", "id": "19423540", "url": "https://glygen.org/publication/PubMed/19423540" } ] }, { "annotation": "Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1 enhances radiosensitivity of non-small cell lung cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, { "database": "PubMed", "id": "35065237", "url": "https://glygen.org/publication/PubMed/35065237" } ] }, { "annotation": "The clinical significance of transcription factor WD repeat and HMG-box DNA binding protein 1 in laryngeal squamous cell carcinoma and its potential molecular mechanism.", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, { "database": "PubMed", "id": "34999279", "url": "https://glygen.org/publication/PubMed/34999279" } ] }, { "annotation": "The protein encoded by this gene contains multiple N-terminal WD40 domains and a C-terminal high mobility group (HMG) box. WD40 domains are found in a variety of eukaryotic proteins and may function as adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" } ] }, { "annotation": "The study indicated that miR-494 overexpression suppresses epithelial-mesenchymal transition, tumor formation and lymph node metastasis while promoting cholangiocarcinoma (CCA) cell apoptosis through inhibiting WDHD1 in CCA.", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, { "database": "PubMed", "id": "30314946", "url": "https://glygen.org/publication/PubMed/30314946" } ] }, { "annotation": "WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, { "database": "PubMed", "id": "32883234", "url": "https://glygen.org/publication/PubMed/32883234" } ] }, { "annotation": "WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. Erratum:[Cell Death Dis. 2021 Mar 15;12(3):269. PMID: 33723224] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" }, { "database": "PubMed", "id": "33221821", "url": "https://glygen.org/publication/PubMed/33221821" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1448518695", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1448518695" }, { "id": "rs1448518695", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1448518695#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1033, "end_pos": 1033, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (ILS->NLS).", "chr_id": "14", "chr_pos": "54944423", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1033", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs771261193", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771261193" }, { "id": "rs771261193", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771261193" }, { "id": "rs771261193", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs771261193" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 105, "end_pos": 105, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGT->NGT).", "chr_id": "14", "chr_pos": "55010337", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D105", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs868036385", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs868036385" }, { "id": "rs868036385", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs868036385" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1091, "end_pos": 1091, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DET->NET).", "chr_id": "14", "chr_pos": "54941609", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D1091", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs745380893", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745380893" }, { "id": "rs745380893", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745380893" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 141, "end_pos": 141, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SLS->NLS).", "chr_id": "14", "chr_pos": "55008639", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S141", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs143976463", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs143976463" }, { "id": "rs143976463", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs143976463" }, { "id": "rs143976463", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs143976463" }, { "id": "rs143976463", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs143976463#frequency_tab" }, { "id": "rs143976463", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs143976463" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 331, "end_pos": 331, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DMS->NMS).", "chr_id": "14", "chr_pos": "54995765", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.000998", "site_lbl": "D331", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1399069550", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1399069550" }, { "id": "rs1399069550", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1399069550" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 342, "end_pos": 342, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDN->NDS).", "chr_id": "14", "chr_pos": "54995731", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N342", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs746746117", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746746117" }, { "id": "rs746746117", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs746746117" }, { "id": "rs746746117", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs746746117#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 391, "end_pos": 391, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TGS->NGS).", "chr_id": "14", "chr_pos": "54991382", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T391", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs201445432", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201445432" }, { "id": "rs201445432", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs201445432" }, { "id": "rs201445432", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201445432" }, { "id": "rs201445432", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs201445432#frequency_tab" }, { "id": "rs201445432", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs201445432" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 412, "end_pos": 412, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLP->NLS).", "chr_id": "14", "chr_pos": "54991320", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000399", "site_lbl": "P412", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1228819962", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1228819962" }, { "id": "rs1228819962", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1228819962" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 480, "end_pos": 480, "sequence_org": "H", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HLS->NLS).", "chr_id": "14", "chr_pos": "54989116", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "H480", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs761890357", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761890357" }, { "id": "rs761890357", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761890357" }, { "id": "rs761890357", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs761890357#frequency_tab" }, { "id": "rs761890357", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs761890357" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 485, "end_pos": 485, "sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTL->NTS).", "chr_id": "14", "chr_pos": "54989100", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L485", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1490517440", 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"Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTA->NTS).", "chr_id": "14", "chr_pos": "54962840", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A849", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O75717", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75717" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 930, "end_pos": 930, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NSA->NST).", "chr_id": "14", "chr_pos": "54957162", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A930", "disease": [ { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O75717", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75717" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O75717", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75717" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O75717", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75717" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75717" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": 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"O75717", "url": "https://pharos.nih.gov/targets/O75717", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75717", "url": "http://purl.obolibrary.org/obo/PR_O75717", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "C9JYB3", "url": "https://www.uniprot.org/uniprot/C9JYB3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JYB3-1", "url": "https://www.uniprot.org/uniprot/C9JYB3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BSQ1", "url": "https://www.uniprot.org/uniprot/H3BSQ1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H3BSQ1-1", "url": "https://www.uniprot.org/uniprot/H3BSQ1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75717-1", "url": "https://www.uniprot.org/uniprot/O75717-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75717-2", "url": "https://www.uniprot.org/uniprot/O75717-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE", "length": 1129, "header": "sp|O75717-1|WDHD1_HUMAN Isoform 1 of WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1 CANONICAL=O75717-1" }, "isoforms": [ { "isoform_ac": "C9JYB3-1", "url": "", "sequence": { "sequence": "MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQ", "length": 168, "header": "tr|C9JYB3-1|C9JYB3_HUMAN Computationally mapped isoform of WD repeat and HMG-box DNA binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1 CANONICAL=O75717-1" }, "locus": { "chromosome": "14", "start_pos": 55026787, "end_pos": 55008316, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000455555.1", "url": "https://www.ensembl.org/id/ENST00000455555.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000413435.1", "url": "https://www.ensembl.org/id/ENSP00000413435.1" } ] } }, { "isoform_ac": "H3BSQ1-1", "url": "", "sequence": { "sequence": "XGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMQASLPAL", "length": 64, "header": "tr|H3BSQ1-1|H3BSQ1_HUMAN Computationally mapped isoform of WD repeat and HMG-box DNA binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1 CANONICAL=O75717-1" }, "locus": { "chromosome": "14", "start_pos": 54991382, "end_pos": 54987366, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000567693.1", "url": "https://www.ensembl.org/id/ENST00000567693.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000456806.1", "url": "https://www.ensembl.org/id/ENSP00000456806.1" } ] } }, { "isoform_ac": "O75717-1", "url": "", "sequence": { "sequence": "MPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE", "length": 1129, "header": "sp|O75717-1|WDHD1_HUMAN Isoform 1 of WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1 CANONICAL=O75717-1" }, "locus": { "chromosome": "14", "start_pos": 55026787, "end_pos": 54941493, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000360586.8", "url": "https://www.ensembl.org/id/ENST00000360586.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000353793.3", "url": "https://www.ensembl.org/id/ENSP00000353793.3" } ] } }, { "isoform_ac": "O75717-2", "url": "", "sequence": { "sequence": "MDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE", "length": 1006, "header": "sp|O75717-2|WDHD1_HUMAN Isoform 2 of WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1 CANONICAL=O75717-1" }, "locus": { "chromosome": "14", "start_pos": 55008691, "end_pos": 54941493, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420358.2", "url": "https://www.ensembl.org/id/ENST00000420358.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000399349.2", "url": "https://www.ensembl.org/id/ENSP00000399349.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 933, "start_aa": "Thr", "end_pos": 933, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr933", "evidence": [ { "id": "O75717", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 943, "start_aa": "Ser", "end_pos": 943, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser943", "evidence": [ { "id": "O75717", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" } ] } ], "phosphorylation": [ { "start_pos": 1041, "end_pos": 1041, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" }, { "database": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" }, { "database": "phospho.ELM", "id": "O75717", "url": "http://phospho.elm.eu.org/byAccession/O75717.html" } ], "site_lbl": "Ser1041" }, { "start_pos": 1090, "end_pos": 1090, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" }, { "database": "phospho.ELM", "id": "O75717", "url": "http://phospho.elm.eu.org/byAccession/O75717.html" } ], "site_lbl": "Ser1090" }, { "start_pos": 323, "end_pos": 323, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O75717", "url": "http://phospho.elm.eu.org/byAccession/O75717.html" } ], "site_lbl": "Tyr323" }, { "start_pos": 333, "end_pos": 333, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" }, { "database": "phospho.ELM", "id": "O75717", "url": "http://phospho.elm.eu.org/byAccession/O75717.html" } ], "site_lbl": "Ser333" }, { "start_pos": 350, "end_pos": 350, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O75717", "url": "http://phospho.elm.eu.org/byAccession/O75717.html" } ], "site_lbl": "Ser350" }, { "start_pos": 374, "end_pos": 374, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "phospho.ELM", "id": "O75717", "url": "http://phospho.elm.eu.org/byAccession/O75717.html" } ], "site_lbl": "Ser374" }, { "start_pos": 383, "end_pos": 383, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" }, { "database": "PubMed", "id": "17322306", "url": "https://glygen.org/publication/PubMed/17322306" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" }, { "database": "PubMed", "id": "18767875", "url": "https://glygen.org/publication/PubMed/18767875" }, { "database": "PubMed", 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Chem.", "date": "2012", "authors": "Duxin JP, Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ Jr, Stewart SA", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "reference": [ { "type": "PubMed", "id": "22570476", "url": "https://glygen.org/publication/PubMed/22570476" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" }, { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75717", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2014", "authors": "Impens F, Radoshevich L, Cossart P, Ribet D", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "reference": [ { "type": "PubMed", "id": "25114211", "url": "https://glygen.org/publication/PubMed/25114211" } ] }, { "title": "SUMO-2 orchestrates chromatin modifiers in response to DNA damage.", "journal": "Cell Rep.", "date": "2015", "authors": "Hendriks Ivo A, Treffers Louise W, Verlaan-de Vries Matty, Olsen Jesper V, Vertegaal Alfred C O", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "reference": [ { "type": "PubMed", "id": "25772364", "url": "https://glygen.org/publication/PubMed/25772364" } ] }, { "title": "And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress.", "journal": "The EMBO journal", "date": "2015", "authors": "Hao J, de Renty C, Li Y, Xiao H, Kemp MG, Han Z, DePamphilis ML, Zhu W", "evidence": [ { "database": "iPTMnet", "id": "O75717", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75717" } ], "reference": [ { "type": "PubMed", "id": "26082189", "url": "https://glygen.org/publication/PubMed/26082189" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75717", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] }, { "title": "MicroRNA-494-dependent WDHDI inhibition suppresses epithelial-mesenchymal transition, tumor growth and metastasis in cholangiocarcinoma.", "journal": "Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver", "date": "2019", "authors": "Liu B, Hu Y, Qin L, Peng XB, Huang YX", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" } ], "reference": [ { "type": "PubMed", "id": "30314946", "url": "https://glygen.org/publication/PubMed/30314946" } ] }, { "title": "CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.", "journal": "Nucleic Acids Res.", "date": "2020", "authors": "Rzechorzek Neil J, Hardwick Steven W, Jatikusumo Vincentius A, Chirgadze Dimitri Y, Pellegrini Luca", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "reference": [ { "type": "PubMed", "id": "32453425", "url": "https://glygen.org/publication/PubMed/32453425" } ] }, { "title": "WDHD1 facilitates G1 checkpoint abrogation in HPV E7 expressing cells by modulating GCN5.", "journal": "BMC cancer", "date": "2020", "authors": "Zhou Y, Pei F, Ji M, Zhang F, Sun Y, Zhao Q, Wang X, Hong Y, Tian J, Wang Y, Chen JJ", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" } ], "reference": [ { "type": "PubMed", "id": "32883234", "url": "https://glygen.org/publication/PubMed/32883234" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75717", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer.", "journal": "Cell death & disease", "date": "2020", "authors": "Ertay A, Liu H, Liu D, Peng P, Hill C, Xiong H, Hancock D, Yuan X, Przewloka MR, Coldwell M, Howell M, Skipp P, Ewing RM, Downward J, Wang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" } ], "reference": [ { "type": "PubMed", "id": "33221821", "url": "https://glygen.org/publication/PubMed/33221821" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75717", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2021", "authors": "Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J, Li X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75717", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" } ], "reference": [ { "type": "PubMed", "id": "34229054", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "title": "Structure of a human replisome shows the organisation and interactions of a DNA replication machine.", "journal": "The EMBO journal", "date": "2021-12-01", "authors": "Jones Morgan L, Baris Yasemin, Taylor Martin R G, Yeeles Joseph T P", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "reference": [ { "type": "PubMed", "id": "34694004", "url": "https://glygen.org/publication/PubMed/34694004" } ] }, { "title": "A conserved mechanism for regulating replisome disassembly in eukaryotes.", "journal": "Nature", "date": "2021", "authors": "Jenkyn-Bedford Michael, Jones Morgan L, Baris Yasemin, Labib Karim P M, Cannone Giuseppe, Yeeles Joseph T P, Deegan Tom D", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "reference": [ { "type": "PubMed", "id": "34700328", "url": "https://glygen.org/publication/PubMed/34700328" } ] }, { "title": "The clinical significance of transcription factor WD repeat and HMG-box DNA binding protein 1 in laryngeal squamous cell carcinoma and its potential molecular mechanism.", "journal": "Pathology, research and practice", "date": "2022", "authors": "Wu JY, Lan XL, Yan DM, Fang YY, Peng YX, Liang FF, Jiang L, Huang SN, Mo M, Lin CX, Niu YT, Wu XW, Wei ZX", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" } ], "reference": [ { "type": "PubMed", "id": "34999279", "url": "https://glygen.org/publication/PubMed/34999279" } ] }, { "title": "Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1 enhances radiosensitivity of non-small cell lung cancer.", "journal": "Cancer letters", "date": "2022", "authors": "Gou W, Yu X, Wu S, Wu H, Chang H, Chen L, Wei H, Bi C, Ning H, Wu Y, Hou W, Zuo D, Li Y", "evidence": [ { "database": "RefSeq", "id": "NP_001008397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008397" } ], "reference": [ { "type": "PubMed", "id": "35065237", "url": "https://glygen.org/publication/PubMed/35065237" } ] }, { "title": "Fast and efficient DNA replication with purified human proteins.", "journal": "Nature", "date": "2022-06", "authors": "Baris Yasemin, Taylor Martin R G, Aria Valentina, Yeeles Joseph T P", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "reference": [ { "type": "PubMed", "id": "35585232", "url": "https://glygen.org/publication/PubMed/35585232" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75717", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75717" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] } ], "pathway": [ { "id": "hsa:11169", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11169", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZN63-1", "protein_name": "WD repeat and HMG-box DNA binding protein 1", "gene_name": "Wdhd1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPAIQKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNGKLVTAVSNNTVQVYTFPEGAPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKVVDVMDNSQQQTFRGHDAPVLSLSFDPKDVFLASASCDGTVRVWNISDQTCAASWPVLRKSNDVVNSESICRLAWQPKTGKFLAVPVEKSVKLYRRETWSNPFDLSDSSVTQTLNIVTWSPCGQYLAAGAINGLIVVWNVETKECMERVKHEKGYAICGLAWHPTYSRICYTDVEGNLGILENVCDLSGKLSSNKVPSGVEKDYSDLFDGDDTSSAGDFLNDNAVEIPSFSKGIRNEEDDNDDLMLAADHVLGDDENSVDVTMLRNDLHREEGEDRQASSLHSLPLVKSQRPLYDGPMPTPRQKPFQPSSTPLHLTHRFMAWNSVGIIRCYNDDQDSAIDVEFHDTSIHHATHLSNAFNYTMGSLSHEAVLLACESADELASKLHCLHFSSWDSSKEWIVDMPENEDIEAICLGLGWAAAATSALLLRLFTIGGVQKEVFCLPGPVVSMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELGRKKKQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILPFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAENGYDYEESIKKQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAEIQTEEREEDFRERLNAGYSHTTTEWSQPRVRSQVEEDAEDREDTVSEGNPEPQNHVIGQNLIQSANSSDTPAMKSGAVFSSSQGRVNPFKVLVSSKEPAVSVNATRSANILDNMNKLSRKSTSFNRVANNEKSPVIKPLIPKPRCKQASAASYFQKRTSQAEKTEEVKENPKSSSSEAPAVCLQNSEVQRPKTGFQMWLEENRSHIMSDNPDISDEADIIKEGMIRFRVLSAEERKEWTNKAKGGTASDGAEAKKRKRGVSEICETEKQEEAVKENLELSKKQKALDLSTNQKLSAFAFKQE", "length": 1119 }, "evidence": [ { "id": "45928128", "url": "http://www.informatics.jax.org/homology/45928128", "database": "MGI" }, { "id": "O75717", "url": "https://omabrowser.org/oma/group/O75717/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P59328-1", "protein_name": "WD repeat and HMG-box DNA-binding protein 1", "gene_name": "Wdhd1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPATQKPMRYGHTEGHTEVCFDDSGSYIVTCGSDGDVRMWEDLDDDDPKSVNVGEKAFSCALKNGKLVTAVSNNTVQVYTFPEGVPDGILTRFTTNANHVVFNGAGNKIAAGSSDFLVKVVDVMDNSQQQTFRGHDAPVLSLSFDPKDIFLASASCDGTVRVWNISDQTCAVSWPVLQKSNDVVNAKSICRLAWQPKAGKLLAVPVEKSVKLYRRETWSNPFDLSDSSISQTLNIVTWSPCGQYLAAGAINGLIVVWNVETKDCMERVKHEKGYAICGLAWHPTCSRICYTDVEGNLGVLENVCDLSGKVSSNKVSSRVEKDYNDLFDGDDTSSAGDFLNDNAVEIPSFSKGIINEDDDNDDIMLAADHDLGDDENSVDVTMLKADLSHKEEGDDDQARSIHNLPLIRPQRPFYDGPMPTPRQKPFQSSSTPLHLSHRFMVWNSVGIIRCYNDDQDSAIDVEFHDTSIHHATHLLNAFNYTMGTLSHEAILLACESADELASKLHCLHFSSWDSSKEWMVDMPQNEDIEAICLGLGWAAAATTALLLRLFTIGGVQKEVFCLPGPVVSMAGHGEQLCIVYHRGTGFDGDQCLGVQLLELGRKKNQVLHGDPLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNTWTPVCNIREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQTSTEKGQMEEQFWHSVLFHNYLDYLAKNGYDYEESIKNQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVHLAIKYASRSRKLILAQKLSELAAEKAAELAETQSEEEKEEDFREKLNAGYSHTTTEWSRPRVRSQVEDAEDREDTVSEEKPESHNHGQNLFQSANSSDTPALKSGAVFSSSQGWVNPFKVVVSSKEPAVSANSTRSANILDSMNKSSRKSTSLNRMENNEKSPVIKPLTPKPRSKQASAASYFQKRTPQADKTEEVKENPKSSSSDAPAVCLQNSENQRPKTGFQMWLEENRSQILSDNPDISDETDIIKEGMIRFRVLSAEERKAWTNKAKGETASDGAEAKKRKRVVSEICETENQEETVKENLDLSKKQKALNLPANQKLSAFAFKQ", "length": 1117 }, "evidence": [ { "id": "45928128", "url": "http://www.informatics.jax.org/homology/45928128", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q01454-1", "protein_name": "DNA polymerase alpha-binding protein", "gene_name": "CTF4", "tax_id": 559292, "organism": "Saccharomyces cerevisiae S288C", "sequence": { "sequence": "MVSVIDKLVFDFGGKTLVSLAPDNNTLCVANKNGLTKILKTNNPEEEPETLDSSKLVSSIKCYSNSHFLMTTMQGDALRYNIDSSQEELLARFALPLRDCCVIHSGKMAVFGGDDLELILLELDDETHKKHAIKIDEQVSQISYNSQMNILAVSMINGKVQIFSLTSTIPNKVHELNDYIVANSYDDTHRDKILSNMMDDIDKDNDNDLSETADPDENNVADPEFCAANRICTRVAWHPKGLHFALPCADDTVKIFSIKGYSLQKTLSTNLSSTKAHFIDLQFDPLRGTYIAAVDLNNKLTVWNWETSEIHYTREFKRKITNIAWKIQADSKTLDLVLGTWSGSIAIVQNLAESVVSNIPDQSVAESSTKHGLFVDSESDLENLEGNDDINKSDKLFSDITQEANAEDVFTQTHDGPSGLSEKRKYNFEDEEDFIDDDDGAGYISGKKPHNEHSYSRVHKTHSFPISLANTGKFRYMPFSPAGTPFGFTDRRYLTMNEVGYVSTVKNSEQYSITVSFFDVGRFREYHFEDLFGYDLCFLNEKGTLFGQSKTGQIQYRPHDSIHSNWTKIIPLQAGERITSVAATPVRVIVGTSLGYFRSFNQFGVPFAVEKTSPIVALTAQNYRVFSVHYSQFHGLSYSLSELGTSSKRYYKRECPLPMSLPNINSDMKKDANLDYYNFNPMGIKSLFFSSYGDPCIFGSDNTLLLLSKWRSPEESKWLPILDSNMEIWKMSGGKETTDIHVWPLALAYDTLNCILVKGKHIWPEFPLPLPSEMEIRMPVFVKSKLLEENKAILNKKNEIGADTEAEEGEEDKEIQIPVSMAAEEEYLRSKVLSELLTDTLENDGEMYGNENEVLAALNGAYDKALLRLFASACSDQNVEKALSLAHELKQDRALTAAVKISERAELPSLVKKINNIREARYEQQLK", "length": 927 }, "evidence": [ { "id": "O75717", "url": "https://omabrowser.org/oma/group/O75717/", "database": "OMA" } ], "common_name": "Yeast" }, { "uniprot_canonical_ac": "Q494K2-1", "protein_name": "LD47422p", "gene_name": "Ctf4", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MSFLRSALRYAHTNGYTGLLYTPRGEFIITCGTDGDIRHWTCISDDDPRSSCLGEFVMCIAHTGTRLLASTDRNTIHAYTFPEMDSDGILMRFTAPATCLKVSGGYTAAGSEDTTIKVLKGDTAGNETVLEGHTGPILALDLFAERKLLVSVAGDGQLKVWNFEEGKELKTIGGLPKVNSFESASLYGTPHFEPQSGELLAYAVDNEIVVLNTANWEVAFKLRDDSVSSNYSCCQFSPNGERLAAGTTKGEVSIFDVKKRKAVTVEIPPSDCNAITCLAWNLSGEVEVAFCDATGQLGTVFLGDAVDTGNGDGLVDDQAELLGDDYEFEAGDDVDTAADDGDGVSLEQLKRKVMNFADPVDHDDASNQSLDSSSRTVPAPVAPQIKLFKQQTAFQPSATPADLEHRYMAWNDVGIVTAHVEPSGDSSIDVEFHDASIHHALHISNYNQHNLASVSSGALALASNESSKLVVIALAAAGNKEWSLSLPDCESAEAVVATRFLVAVATSSSFLRIFTVMGTQREVLTIPGPMVAIAGHEHSLMVVYHSSAPSQTQQHLAAMLVNINGLSLRQEYLPVPLTPGRQLTWFGYSDTGSPSIADNMGLLQLYRRSSNAWFPICDTMKQSTSVSHNFFVVAVSEKRQIVQAVLCRGTSYPMTNPRPMLQELRMQIPLCDVEVEKSELEDALLRSSLMQMDGAEKMQKETAIKLFALACSSECETRARELIESIACTDLLQLAVKYATKRGRIHLSDRLCELLPQLEAVQEARKQQTLLGASGIAATIVLPMTPTSASQSGPKPKAIELSSAKRGTLKRLVNSPNMFKAAAASAASRPSTPDITPSPLDTQENIFGESESEVPMGKATDHRSPLNSVNPFAMKRKLGDTGVIFGSEKLKLAKK", "length": 895 }, "evidence": [ { "id": "O75717", "url": "https://omabrowser.org/oma/group/O75717/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nuclear replication fork", "id": "GO:0043596", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043596", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" }, { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "mitotic cell cycle", "id": "GO:0000278", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000278", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" }, { "name": "DNA-templated DNA replication", "id": "GO:0006261", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006261", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "DNA binding", "id": "GO:0003677", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "O75717", "url": "https://www.uniprot.org/uniprot/O75717" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1029, "end_pos": 1031, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1105, "end_pos": 1107, "annotation": "n_glycosylation_sequon" }, { "start_pos": 486, "end_pos": 488, "annotation": "n_glycosylation_sequon" }, { "start_pos": 73, "end_pos": 75, "annotation": "n_glycosylation_sequon" }, { "start_pos": 892, "end_pos": 894, "annotation": "n_glycosylation_sequon" }, { "start_pos": 987, "end_pos": 989, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": 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