{ "uniprot_canonical_ac": "O75553-1", "uniprot_ac": "O75553", "uniprot_id": "DAB1_HUMAN", "mass": { "chemical_mass": 63775.0, "monoisotopic_mass": 63775.0 }, "refseq": { "ac": "NP_066566", "name": "disabled homolog 1 isoform 1", "summary": "The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" }, "gene_names": [ { "name": "DAB1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75553", "id": "O75553" }, { "name": "DAB1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566", "id": "NP_066566" }, { "name": "SCA37", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566", "id": "NP_066566" } ], "protein_names": [ { "name": "Disabled homolog 1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75553" }, { "name": "disabled homolog 1 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566", "id": "NP_066566" }, { "name": "disabled homolog 1; Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; DAB1, reelin adaptor protein; yotari; spinocerebellar ataxia 37", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566", "id": "NP_066566" } ], "function": [ { "annotation": "Adapter molecule functioning in neural development. May regulate SIAH1 activity.", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553#function" }, { "database": "UniProtKB", "id": "P97318", "url": "https://www.uniprot.org/uniprot/P97318#function" } ] }, { "annotation": "ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" }, { "database": "PubMed", "id": "38093390", "url": "https://glygen.org/publication/PubMed/38093390" } ] }, { "annotation": "Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" }, { "database": "PubMed", "id": "33572344", "url": "https://glygen.org/publication/PubMed/33572344" } ] }, { "annotation": "Inhibition of microRNA-300 inhibits cell adhesion, migration, and invasion of prostate cancer cells by promoting the expression of DAB1.", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" }, { "database": "PubMed", "id": "33064976", "url": "https://glygen.org/publication/PubMed/33064976" } ] }, { "annotation": "The appearance of DAB1 and Reelin during fetal kidney development confirms their potential significant role in the formation of kidney structure or function. High DAB1 expression in the DCT implies its regulatory role in tubular formation or function maintenance during development.", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" }, { "database": "PubMed", "id": "31894918", "url": "https://glygen.org/publication/PubMed/31894918" } ] }, { "annotation": "The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. [provided by RefSeq, Jan 2017].", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" } ] }, { "annotation": "Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" }, { "database": "PubMed", "id": "35977442", "url": "https://glygen.org/publication/PubMed/35977442" } ] } ], "disease": [ { "disease_id": "DOID:0050984", "recommended_name": { "id": "DOID:0050984", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0050984", "name": "spinocerebellar ataxia type 37", "description": "An autosomal dominant cerebellar ataxia that is characterized by progressive ataxia and dysarthria, presenting in mid-adulthood, and has_material_basis_in mutation to the DAB1 gene." }, "synonyms": [ { "id": "MONDO:0014410", "resource": "MONDO", "url": 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tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", 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"name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O75553", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75553" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" } ], "common_name": "Human" } ], "gene": [ { "name": "DAB1", "url": "https://www.uniprot.org/uniprot/O75553", "locus": { "chromosome": "1", "start_pos": 56994778, "end_pos": 58546734, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000173406", "url": "https://www.ensembl.org/id/ENSG00000173406" } ] } } ], "crossref": [ { "id": "ENSG00000173406", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000173406", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O75553", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75553", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd01215", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01215", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DAB1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=DAB1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "1600", "url": "https://www.ncbi.nlm.nih.gov/gene/1600", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "2661", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2661", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O75553", "url": "https://www.ebi.ac.uk/intact/interactors/id:O75553*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR006020", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006020", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048559", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048559", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048561", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048561", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:1600", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1600", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603448", "url": "http://www.omim.org/entry/603448", "database": "MIM", "categories": [ "Other" ] }, { "id": "615945", "url": "http://www.omim.org/entry/615945", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O75553", "url": "https://www.nextprot.org/entry/NX_O75553", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O75553", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75553", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "FDEKTGX", "url": "https://omabrowser.org/oma/group/FDEKTGX/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2913989at2759", "url": "http://www.orthodb.org/?query=2913989at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR47695", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47695", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47695:SF4", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47695:SF4", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00640", "url": "http://pfam.xfam.org/family/PF00640", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF21792", "url": "http://pfam.xfam.org/family/PF21792", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O75553", "url": "https://pharos.nih.gov/targets/O75553", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75553", "url": "http://purl.obolibrary.org/obo/PR_O75553", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A075B6G7", "url": "https://www.uniprot.org/uniprot/A0A075B6G7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A075B6G7-1", "url": "https://www.uniprot.org/uniprot/A0A075B6G7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75553-1", "url": "https://www.uniprot.org/uniprot/O75553-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75553-2", "url": "https://www.uniprot.org/uniprot/O75553-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75553-3", "url": "https://www.uniprot.org/uniprot/O75553-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75553-4", "url": "https://www.uniprot.org/uniprot/O75553-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75553-5", "url": "https://www.uniprot.org/uniprot/O75553-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75553-6", "url": "https://www.uniprot.org/uniprot/O75553-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6R4J9", "url": "https://www.uniprot.org/uniprot/X6R4J9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "X6R4J9-1", "url": "https://www.uniprot.org/uniprot/X6R4J9-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS", "length": 588, "header": "sp|O75553-1|DAB1_HUMAN Isoform 1 of Disabled homolog 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=3 CANONICAL=O75553-1" }, "isoforms": [ { "isoform_ac": "A0A075B6G7-1", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGA", "length": 239, "header": "tr|A0A075B6G7-1|A0A075B6G7_HUMAN Computationally mapped isoform of DAB adaptor protein 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=1 CANONICAL=O75553-1" }, "locus": { "chromosome": "1", "start_pos": 57291030, "end_pos": 57015352, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000371232.8", "url": "https://www.ensembl.org/id/ENST00000371232.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000360276.4", "url": "https://www.ensembl.org/id/ENSP00000360276.4" } ] } }, { "isoform_ac": "O75553-1", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS", "length": 588, "header": "sp|O75553-1|DAB1_HUMAN Isoform 1 of Disabled homolog 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=3 CANONICAL=O75553-1" }, "locus": { "chromosome": "1", "start_pos": 57291030, "end_pos": 57010698, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000371231.5", "url": "https://www.ensembl.org/id/ENST00000371231.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000360275.1", "url": "https://www.ensembl.org/id/ENSP00000360275.1" } ] } }, { "isoform_ac": "O75553-2", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQVISETSRGFRFKSD", "length": 213, "header": "sp|O75553-2|DAB1_HUMAN Isoform 2 of Disabled homolog 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=3 CANONICAL=O75553-1" }, "locus": { "chromosome": "1", "start_pos": 57291030, "end_pos": 57070981, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000371230.1", "url": "https://www.ensembl.org/id/ENST00000371230.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000360274.1", "url": "https://www.ensembl.org/id/ENSP00000360274.1" } ] } }, { "isoform_ac": "O75553-3", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS", "length": 469, "header": "sp|O75553-3|DAB1_HUMAN Isoform 3 of Disabled homolog 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=3 CANONICAL=O75553-1" }, "locus": {} }, { "isoform_ac": "O75553-4", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS", "length": 537, "header": "sp|O75553-4|DAB1_HUMAN Isoform 4 of Disabled homolog 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=3 CANONICAL=O75553-1" }, "locus": {} }, { "isoform_ac": "O75553-5", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQVPTSQKKEGVYDVPKSQPVSNGYSFEDFEERFAAATPNRNLPTDFDEIFEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS", "length": 553, "header": "sp|O75553-5|DAB1_HUMAN Isoform 5 of Disabled homolog 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=3 CANONICAL=O75553-1" }, "locus": { "chromosome": "1", "start_pos": 57291030, "end_pos": 57010698, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420954.6", "url": "https://www.ensembl.org/id/ENST00000420954.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000395296.2", "url": "https://www.ensembl.org/id/ENSP00000395296.2" } ] } }, { "isoform_ac": "O75553-6", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPVSAVTQLELFGDMSTPPDITSPPTPATPGDAFIPSSSQTLPASADVFSSVPFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQMVMGAQPPVAQVMPGAQPIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTSDSTRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAPDGSQASSNSDPFGEPSGEPSGDNISPQAGS", "length": 555, "header": "sp|O75553-6|DAB1_HUMAN Isoform 6 of Disabled homolog 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=3 CANONICAL=O75553-1" }, "locus": { "chromosome": "1", "start_pos": 57291030, "end_pos": 57010698, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000414851.6", "url": "https://www.ensembl.org/id/ENST00000414851.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000387581.3", "url": "https://www.ensembl.org/id/ENSP00000387581.3" } ] } }, { "isoform_ac": "X6R4J9-1", "url": "", "sequence": { "sequence": "MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQVPTSQKKEGVYDVPKSQP", "length": 204, "header": "tr|X6R4J9-1|X6R4J9_HUMAN Computationally mapped isoform of DAB adaptor protein 1 OS=Homo sapiens OX=9606 GN=DAB1 PE=1 SV=1 CANONICAL=O75553-1" }, "locus": { "chromosome": "1", "start_pos": 57291030, "end_pos": 57062890, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000332102.10", "url": "https://www.ensembl.org/id/ENST00000332102.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000329120.6", "url": "https://www.ensembl.org/id/ENSP00000329120.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O75553", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75553" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [ { "start_pos": 198, "end_pos": 198, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" }, { "database": "phospho.ELM", "id": "O75553", "url": "http://phospho.elm.eu.org/byAccession/O75553.html" }, { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" }, { "database": "PubMed", "id": "15316068", "url": "https://glygen.org/publication/PubMed/15316068" }, { "database": "PRO", "id": "O75553", "url": "http://purl.obolibrary.org/obo/O75553" }, { "database": "PubMed", "id": "18593473", "url": "https://glygen.org/publication/PubMed/18593473" }, { "database": "PubMed", "id": "27602387", "url": "https://glygen.org/publication/PubMed/27602387" } ], "site_lbl": "Tyr198" }, { "start_pos": 220, "end_pos": 220, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" }, { "database": "phospho.ELM", "id": "O75553", "url": "http://phospho.elm.eu.org/byAccession/O75553.html" }, { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" }, { "database": "PubMed", "id": "15316068", "url": "https://glygen.org/publication/PubMed/15316068" }, { "database": "PRO", "id": "O75553", "url": "http://purl.obolibrary.org/obo/O75553" }, { "database": "PubMed", "id": "19116273", "url": "https://glygen.org/publication/PubMed/19116273" }, { "database": "PubMed", "id": "29590626", "url": "https://glygen.org/publication/PubMed/29590626" } ], "site_lbl": "Tyr220" }, { "start_pos": 232, "end_pos": 232, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" }, { "database": "phospho.ELM", "id": "O75553", "url": "http://phospho.elm.eu.org/byAccession/O75553.html" }, { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" }, { "database": "PubMed", "id": "15316068", "url": "https://glygen.org/publication/PubMed/15316068" }, { "database": "PRO", "id": "O75553", "url": "http://purl.obolibrary.org/obo/O75553" }, { "database": "PubMed", "id": "29590626", "url": "https://glygen.org/publication/PubMed/29590626" } ], "site_lbl": "Tyr232" }, { "start_pos": 433, "end_pos": 433, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" }, { "database": "PubMed", "id": "12077184", "url": "https://glygen.org/publication/PubMed/12077184" }, { "database": "PubMed", "id": "18076569", "url": "https://glygen.org/publication/PubMed/18076569" } ], "site_lbl": "Ser433" }, { "start_pos": 524, "end_pos": 524, "kinase_uniprot_canonical_ac": "P24941-1", "kinase_gene_name": "CDK2", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" }, { "database": "PubMed", "id": "21111810", "url": "https://glygen.org/publication/PubMed/21111810" } ], "site_lbl": "Ser524" }, { "start_pos": 524, "end_pos": 524, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CDK5", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" }, { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" }, { "database": "PubMed", "id": "12077184", "url": "https://glygen.org/publication/PubMed/12077184" }, { "database": "PubMed", "id": "18076569", "url": "https://glygen.org/publication/PubMed/18076569" }, { "database": "phospho.ELM", "id": "O75553", "url": "http://phospho.elm.eu.org/byAccession/O75553.html" } ], "site_lbl": "Ser524" }, { "start_pos": 548, "end_pos": 548, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O75553", "url": "http://phospho.elm.eu.org/byAccession/O75553.html" }, { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" }, { "database": "PubMed", "id": "12077184", "url": "https://glygen.org/publication/PubMed/12077184" } ], "site_lbl": "Ser548" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.", "journal": "Neuron", "date": "1999", "authors": "Hiesberger T, Trommsdorff M, Howell BW, Goffinet A, Mumby MC, Cooper JA, Herz J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "10571241", "url": "https://glygen.org/publication/PubMed/10571241" } ] }, { "title": "Cyclin-dependent kinase 5 phosphorylates disabled 1 independently of Reelin signaling.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2002", "authors": "Keshvara L, Magdaleno S, Benhayon D, Curran T", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "12077184", "url": "https://glygen.org/publication/PubMed/12077184" } ] }, { "title": "The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Bar I, Tissir F, Lambert de Rouvroit C, De Backer O, Goffinet AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "12446734", "url": "https://glygen.org/publication/PubMed/12446734" } ] }, { "title": "Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.", "journal": "J. Biol. Chem.", "date": "2004", "authors": "Ranganathan S, Liu CX, Migliorini MM, Von Arnim CA, Peltan ID, Mikhailenko I, Hyman BT, Strickland DK", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" } ], "reference": [ { "type": "PubMed", "id": "15272003", "url": "https://glygen.org/publication/PubMed/15272003" } ] }, { "title": "Interaction between Dab1 and CrkII is promoted by Reelin signaling.", "journal": "Journal of cell science", "date": "2004", "authors": "Chen K, Ochalski PG, Tran TS, Sahir N, Schubert M, Pramatarova A, Howell BW", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "15316068", "url": "https://glygen.org/publication/PubMed/15316068" } ] }, { "title": "Modulation of Reelin signaling by Cyclin-dependent kinase 5.", "journal": "Brain research", "date": "2007", "authors": "Ohshima T, Suzuki H, Morimura T, Ogawa M, Mikoshiba K", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "16529723", "url": "https://glygen.org/publication/PubMed/16529723" } ] }, { "title": "Hierarchical disabled-1 tyrosine phosphorylation in Src family kinase activation and neurite formation.", "journal": "Journal of molecular biology", "date": "2007", "authors": "Katyal S, Gao Z, Monckton E, Glubrecht D, Godbout R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "17350651", "url": "https://glygen.org/publication/PubMed/17350651" } ] }, { "title": "Regulation of the interaction of Disabled-1 with CIN85 by phosphorylation with Cyclin-dependent kinase 5.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2007", "authors": "Sato Y, Taoka M, Sugiyama N, Kubo K, Fuchigami T, Asada A, Saito T, Nakajima K, Isobe T, Hisanaga S", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "18076569", "url": "https://glygen.org/publication/PubMed/18076569" } ] }, { "title": "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1.", "journal": "BMC developmental biology", "date": "2008", "authors": "Keilani S, Sugaya K", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "18593473", "url": "https://glygen.org/publication/PubMed/18593473" } ] }, { "title": "Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2009", "authors": "Yang XV, Banerjee Y, Fernandez JA, Deguchi H, Xu X, Mosnier LO, Urbanus RT, de Groot PG, White-Adams TC, McCarty OJ, Griffin JH", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "19116273", "url": "https://glygen.org/publication/PubMed/19116273" } ] }, { "title": "Serine phosphorylation regulates disabled-1 early isoform turnover independently of Reelin.", "journal": "Cellular signalling", "date": "2011", "authors": "Gao Z, Godbout R", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "21111810", "url": "https://glygen.org/publication/PubMed/21111810" } ] }, { "title": "Reelin-Disabled-1 signaling in neuronal migration: splicing takes the stage.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2013", "authors": "Gao Z, Godbout R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "23052211", "url": "https://glygen.org/publication/PubMed/23052211" } ] }, { "title": "Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2013", "authors": "Fuchigami T, Sato Y, Tomita Y, Takano T, Miyauchi SY, Tsuchiya Y, Saito T, Kubo K, Nakajima K, Fukuda M, Hattori M, Hisanaga S", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "23506116", "url": "https://glygen.org/publication/PubMed/23506116" } ] }, { "title": "Schizophrenia patient-derived olfactory neurosphere-derived cells do not respond to extracellular reelin.", "journal": "NPJ schizophrenia", "date": "2016", "authors": "Tee JY, Sutharsan R, Fan Y, Mackay-Sim A", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "27602387", "url": "https://glygen.org/publication/PubMed/27602387" } ] }, { "title": "A pentanucleotide ATTTC repeat insertion in the non-coding region of DAB1, mapping to SCA37, causes spinocerebellar ataxia.", "journal": "Am. J. Hum. Genet.", "date": "2017", "authors": "Seixas AI, Loureiro JR, Costa C, Ordonez-Ugalde A, Marcelino H, Oliveira CL, Loureiro JL, Dhingra A, Brandao E, Cruz VT, Timoteo A, Quintans B, Rouleau GA, Rizzu P, Carracedo A, Bessa J, Heutink P, Sequeiros J, Sobrido MJ, Coutinho P, Silveira I", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" } ], "reference": [ { "type": "PubMed", "id": "28686858", "url": "https://glygen.org/publication/PubMed/28686858" } ] }, { "title": "DCC-Mediated Dab1 Phosphorylation Participates in the Multipolar-to-Bipolar Transition of Migrating Neurons.", "journal": "Cell reports", "date": "2018-03-27", "authors": "Zhang Jian-Hua, Zhao Yi-Fei, He Xiao-Xiao, Zhao Yang, He Zi-Xuan, Zhang Lei, Huang Ying, Wang Yu-Bing, Hu Ling, Liu Lin, Yu Hua-Li, Xu Jia-Hui, Lai Ming-Ming, Zhao Dong-Dong, Cui Lei, Guo Wei-Xiang, Xiong Wen-Cheng, Ding Yu-Qiang, Zhu Xiao-Juan", "evidence": [ { "database": "iPTMnet", "id": "O75553", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75553" } ], "reference": [ { "type": "PubMed", "id": "29590626", "url": "https://glygen.org/publication/PubMed/29590626" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75553", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75553" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Expression and localization of DAB1 and Reelin during normal human kidney development.", "journal": "Croatian medical journal", "date": "2019", "authors": "Racetin A, Juric M, Filipovic N, Solic I, Kosovic I, Glavina Durdov M, Kunac N, Zekic Tomas S, Saraga M, Soljic V, Martinovic V, Petricevic J, Restovic I, Lasic V, Kostic S, Kablar B, Watanabe K, Katsuyama Y, Saraga Babic M, Vukojevic K", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" } ], "reference": [ { "type": "PubMed", "id": "31894918", "url": "https://glygen.org/publication/PubMed/31894918" } ] }, { "title": "Inhibition of microRNA-300 inhibits cell adhesion, migration, and invasion of prostate cancer cells by promoting the expression of DAB1.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2020", "authors": "Li L, Hao J, Yan CQ, Wang HF, Meng B, Cai SY", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" } ], "reference": [ { "type": "PubMed", "id": "33064976", "url": "https://glygen.org/publication/PubMed/33064976" } ] }, { "title": "Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor.", "journal": "International journal of molecular sciences", "date": "2021", "authors": "Dlugosz P, Teufl M, Schwab M, Kohl KE, Nimpf J", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" } ], "reference": [ { "type": "PubMed", "id": "33572344", "url": "https://glygen.org/publication/PubMed/33572344" } ] }, { "title": "Whole genome analysis in APOE4 homozygotes identifies the DAB1-RELN pathway in Alzheimer's disease pathogenesis.", "journal": "Neurobiology of aging", "date": "2022", "authors": "Bracher-Smith M, Leonenko G, Baker E, Crawford K, Graham AC, Salih DA, Howell BW, Hardy J, Escott-Price V", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" } ], "reference": [ { "type": "PubMed", "id": "35977442", "url": "https://glygen.org/publication/PubMed/35977442" } ] }, { "title": "ApoER2-Dab1 disruption as the origin of pTau-associated neurodegeneration in sporadic Alzheimer's disease.", "journal": "Acta neuropathologica communications", "date": "2023-12-13", "authors": "Ramsden Christopher E, Zamora Daisy, Horowitz Mark S, Jahanipour Jahandar, Calzada Elizabeth, Li Xiufeng, Keyes Gregory S, Murray Helen C, Curtis Maurice A, Faull Richard M, Sedlock Andrea, Maric Dragan", "evidence": [ { "database": "RefSeq", "id": "NP_066566", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066566" } ], "reference": [ { "type": "PubMed", "id": "38093390", "url": "https://glygen.org/publication/PubMed/38093390" } ] }, { "title": "The human reelin gene: isolation, sequencing, and mapping on chromosome 7.", "journal": "Genome research", "date": "1997", "authors": "DeSilva U, D'Arcangelo G, Braden VV, Chen J, Miao GG, Curran T, Green ED", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "9049633", "url": "https://glygen.org/publication/PubMed/9049633" } ] }, { "title": "Cloning of human DAB1 and mapping to chromosome 1p31-p32.", "journal": "Genomics", "date": "1998", "authors": "Lambert de Rouvroit C, Goffinet A M", "evidence": [ { "database": "UniProtKB", "id": "O75553", "url": "https://www.uniprot.org/uniprot/O75553" } ], "reference": [ { "type": "PubMed", "id": "9790777", "url": "https://glygen.org/publication/PubMed/9790777" } ] }, { "title": "A decrease of reelin expression as a putative vulnerability factor in schizophrenia.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Impagnatiello F, Guidotti AR, Pesold C, Dwivedi Y, Caruncho H, Pisu MG, Uzunov DP, Smalheiser NR, Davis JM, Pandey GN, Pappas GD, Tueting P, Sharma RP, Costa E", "evidence": [ { "database": "Reactome", "id": "R-HSA-8866376", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376" } ], "reference": [ { "type": "PubMed", "id": "9861036", "url": "https://glygen.org/publication/PubMed/9861036" } ] } ], "pathway": [ { "id": "hsa:1600", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:1600", "resource": "KEGG Pathway" }, { "id": "R-HSA-8866376", "name": "Reelin signalling pathway", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8866376", "resource": "Reactome", "description": "Reelin signalling pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P97318-1", "protein_name": "Disabled homolog 1", "gene_name": "Dab1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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