{ "uniprot_canonical_ac": "O75417-1", "uniprot_ac": "O75417", "uniprot_id": "DPOLQ_HUMAN", "mass": { "chemical_mass": 289619.0, "monoisotopic_mass": 289619.0 }, "refseq": { "ac": "NP_955452", "name": "DNA polymerase theta", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" }, "gene_names": [ { "name": "POLQ", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75417", "id": "O75417" }, { "name": "POLH", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75417", "id": "O75417" }, { "name": "POLQ", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452", "id": "NP_955452" }, { "name": "PRO0327", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452", "id": "NP_955452" } ], "protein_names": [ { "name": "DNA polymerase theta", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75417" }, { "name": "2.7.7.49", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75417" }, { "name": "DNA polymerase eta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75417" }, { "name": "DNA polymerase theta", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452", "id": "NP_955452" }, { "name": "RNA-directed DNA polymerase POLQ", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75417" }, { "name": "polymerase (DNA directed), theta; polymerase (DNA) theta; epididymis secretory sperm binding protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452", "id": "NP_955452" } ], "function": [ { "annotation": "DNA Pol theta has a specialized function in lymphocytes and in tumor progression", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" }, { "database": "PubMed", "id": "14735462", "url": "https://glygen.org/publication/PubMed/14735462" } ] }, { "annotation": "DNA polymerase theta purified from human cells is a high-fidelity enzyme.", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" }, { "database": "PubMed", "id": "12051913", "url": "https://glygen.org/publication/PubMed/12051913" } ] }, { "annotation": "Low-fidelity DNA polymerase with a helicase activity that promotes microhomology-mediated end-joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery required to repair double-strand breaks in DNA during mitosis (PubMed:14576298, PubMed:18503084, PubMed:24648516, PubMed:25642963, PubMed:25643323, PubMed:27311885, PubMed:27591252, PubMed:30655289, PubMed:31562312, PubMed:32873648, PubMed:34179826, PubMed:34140467, PubMed:25775267, PubMed:26636256, PubMed:36455556, PubMed:37674080, PubMed:37440612). MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation (PubMed:25642963, PubMed:25643323, PubMed:27311885, PubMed:27591252, PubMed:31562312, PubMed:32873648, PubMed:25775267). MMEJ is required during mitosis to repair persistent double-strand breaks that originate in S-phase (PubMed:37674080, PubMed:37440612). Although error-prone, MMEJ protects against chromosomal instability and tumorigenesis (By similarity). The polymerase acts by binding directly the 2 ends of resected double-strand breaks, allowing microhomologous sequences in the overhangs to form base pairs (PubMed:25643323, PubMed:27311885, PubMed:27591252, PubMed:25775267). It then extends each strand from the base-paired region using the opposing overhang as a template (PubMed:25643323, PubMed:27311885, PubMed:27591252, PubMed:25775267). Requires partially resected DNA containing 2 to 6 base pairs of microhomology to perform MMEJ (PubMed:25643323, PubMed:27311885, PubMed:27591252, PubMed:25775267). The polymerase lacks proofreading activity and is highly promiscuous: unlike most polymerases, promotes extension of ssDNA and partial ssDNA (pssDNA) substrates (PubMed:18503084, PubMed:21050863, PubMed:22135286). When the ends of a break do not contain terminal microhomology must identify embedded complementary sequences through a scanning step (PubMed:32234782). Also shows endonuclease activity, which is required to trim the 3' ends before synthesis can occur, thereby preventing non-paired tails (PubMed:33577776). Also acts as a DNA helicase, promoting dissociation of the replication protein A complex (RPA/RP-A), composed of RPA1, RPA2 and RPA3, from resected double-strand breaks to allow their annealing and subsequent joining by MMEJ (PubMed:36455556). Removal of RPA/RP-A complex proteins prevents RAD51 accumulation at resected ends, thereby inhibiting homology-recombination repair (HR) pathway (PubMed:25642963, PubMed:28695890). Also shows RNA-directed DNA polymerase activity to mediate DNA repair in vitro; however this activity needs additional evidence in vivo (PubMed:34117057). May also have lyase activity (PubMed:19188258). Involved in somatic hypermutation of immunoglobulin genes, a process that requires the activity of DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs (By similarity). POLQ-mediated end joining activity is involved in random integration of exogenous DNA hampers (PubMed:28695890).", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417#function" }, { "database": "PubMed", "id": "25642963", "url": "https://glygen.org/publication/PubMed/25642963" }, { "database": "PubMed", "id": "22135286", "url": "https://glygen.org/publication/PubMed/22135286" }, { "database": "PubMed", "id": "18503084", "url": "https://glygen.org/publication/PubMed/18503084" }, { "database": "PubMed", "id": "21050863", "url": "https://glygen.org/publication/PubMed/21050863" }, { "database": "UniProtKB", "id": "Q8CGS6", "url": "https://www.uniprot.org/uniprot/Q8CGS6#function" }, { "database": "PubMed", "id": "25643323", "url": "https://glygen.org/publication/PubMed/25643323" }, { "database": "PubMed", "id": "14576298", "url": "https://glygen.org/publication/PubMed/14576298" }, { "database": "PubMed", "id": "19188258", "url": "https://glygen.org/publication/PubMed/19188258" }, { "database": "PubMed", "id": "24648516", "url": "https://glygen.org/publication/PubMed/24648516" }, { "database": "PubMed", "id": "31562312", "url": "https://glygen.org/publication/PubMed/31562312" }, { "database": "PubMed", "id": "26636256", "url": "https://glygen.org/publication/PubMed/26636256" }, { "database": "PubMed", "id": "37440612", "url": "https://glygen.org/publication/PubMed/37440612" }, { "database": "PubMed", "id": "32873648", "url": "https://glygen.org/publication/PubMed/32873648" }, { "database": "PubMed", "id": "30655289", "url": "https://glygen.org/publication/PubMed/30655289" }, { "database": "PubMed", "id": "36455556", "url": "https://glygen.org/publication/PubMed/36455556" }, { "database": "PubMed", "id": "28695890", "url": "https://glygen.org/publication/PubMed/28695890" }, { "database": "PubMed", "id": "34117057", "url": "https://glygen.org/publication/PubMed/34117057" }, { "database": "PubMed", "id": "32234782", "url": "https://glygen.org/publication/PubMed/32234782" }, { "database": "PubMed", "id": "27591252", "url": "https://glygen.org/publication/PubMed/27591252" }, { "database": "PubMed", "id": "34140467", "url": "https://glygen.org/publication/PubMed/34140467" }, { "database": "PubMed", "id": "33577776", "url": "https://glygen.org/publication/PubMed/33577776" }, { "database": "PubMed", "id": "27311885", "url": "https://glygen.org/publication/PubMed/27311885" }, { "database": "PubMed", "id": "25775267", "url": "https://glygen.org/publication/PubMed/25775267" }, { "database": "PubMed", "id": "34179826", "url": "https://glygen.org/publication/PubMed/34179826" }, { "database": "PubMed", "id": "37674080", "url": "https://glygen.org/publication/PubMed/37674080" } ] }, { "annotation": "Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases nu and theta in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells.", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" }, { "database": "PubMed", "id": "35815634", "url": "https://glygen.org/publication/PubMed/35815634" } ] }, { "annotation": "Poltheta; is phosphorylated by PLK1 to repair double-strand breaks in mitosis. Erratum:[Nature. 2024 Jan 25;:. PMID: 38273133]", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" }, { "database": "PubMed", "id": "37674080", "url": "https://glygen.org/publication/PubMed/37674080" } ] }, { "annotation": "The isolation of the full-length human DNA POLQ gene, and an initial characterization of its gene product, DNA polymerase theta", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" }, { "database": "PubMed", "id": "14576298", "url": "https://glygen.org/publication/PubMed/14576298" } ] }, { "annotation": "[Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells].", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" }, { "database": "PubMed", "id": "37153990", "url": "https://glygen.org/publication/PubMed/37153990" } ] } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "evidence": [ { "id": "114480", "database": "MIM", "url": "https://www.omim.org/entry/114480" } ] } ], "snv": [ { "evidence": [ { "id": "rs551658820", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs551658820" }, { "id": "rs551658820", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs551658820" }, { "id": "rs551658820", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs551658820" }, { "id": "rs551658820", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs551658820#frequency_tab" }, { "id": "rs551658820", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs551658820" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1031, "end_pos": 1031, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NFN->NFS).", "chr_id": "3", "chr_pos": "121489839", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "N1031", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O75417", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75417" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1036, "end_pos": 1036, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (SRS->NRS).", "chr_id": "3", "chr_pos": "121489824", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S1036", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75417" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { 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Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "common_name": "Human" } ], "gene": [ { "name": "POLQ", "url": "https://www.uniprot.org/uniprot/O75417", "locus": { "chromosome": "3", "start_pos": 121431431, "end_pos": 121545988, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000051341", "url": "https://www.ensembl.org/id/ENSG00000051341" } ] } } ], "crossref": [ { "id": "ENSG00000051341", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000051341", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O75417", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75417", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd08638", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd08638", "database": "CDD", 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"id": "IPR019760", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019760", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036397", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036397", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043502", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043502", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046931", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046931", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR048960", "url": "https://www.ebi.ac.uk/interpro/entry/IPR048960", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:10721", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10721", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "114480", "url": "http://www.omim.org/entry/114480", "database": "MIM", "categories": [ "Other" ] }, { "id": "604419", "url": "http://www.omim.org/entry/604419", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O75417", "url": "https://www.nextprot.org/entry/NX_O75417", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O75417", "url": "https://oglcnac.org/atlas/detail/O75417", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O75417", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75417", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "208079at2759", "url": "http://www.orthodb.org/?query=208079at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10133", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10133", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR10133:SF62", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10133:SF62", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47961", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47961", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR47961:SF6", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47961:SF6", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "4X0P", "url": "https://www.rcsb.org/structure/4X0P", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "4X0Q", "url": "https://www.rcsb.org/structure/4X0Q", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5A9F", "url": "https://www.rcsb.org/structure/5A9F", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5A9J", "url": "https://www.rcsb.org/structure/5A9J", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5AGA", "url": "https://www.rcsb.org/structure/5AGA", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6XBU", "url": "https://www.rcsb.org/structure/6XBU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7ZUS", "url": "https://www.rcsb.org/structure/7ZUS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7ZX0", "url": "https://www.rcsb.org/structure/7ZX0", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7ZX1", "url": "https://www.rcsb.org/structure/7ZX1", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8E23", "url": "https://www.rcsb.org/structure/8E23", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "8E24", "url": "https://www.rcsb.org/structure/8E24", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00270", "url": "http://pfam.xfam.org/family/PF00270", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00271", "url": "http://pfam.xfam.org/family/PF00271", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00476", "url": "http://pfam.xfam.org/family/PF00476", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20470", "url": "http://pfam.xfam.org/family/PF20470", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF21099", "url": "http://pfam.xfam.org/family/PF21099", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O75417", "url": "https://pharos.nih.gov/targets/O75417", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75417", "url": "http://purl.obolibrary.org/obo/PR_O75417", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5685939", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5685939", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "13065", "url": "https://www.rhea-db.org/rhea/13065", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "22508", "url": "https://www.rhea-db.org/rhea/22508", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A804HJJ9", "url": "https://www.uniprot.org/uniprot/A0A804HJJ9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A804HJJ9-1", "url": "https://www.uniprot.org/uniprot/A0A804HJJ9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75417-1", "url": "https://www.uniprot.org/uniprot/O75417-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75417-2", "url": "https://www.uniprot.org/uniprot/O75417-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV", "length": 2590, "header": "sp|O75417-1|DPOLQ_HUMAN Isoform 1 of DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=1 SV=2 CANONICAL=O75417-1" }, "isoforms": [ { "isoform_ac": "A0A804HJJ9-1", "url": "", "sequence": { "sequence": "XPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQLFQRHSSQQSWSYMVTSLNLDPK", "length": 67, "header": "tr|A0A804HJJ9-1|A0A804HJJ9_HUMAN Computationally mapped isoform of DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=4 SV=1 CANONICAL=O75417-1" }, "locus": { "chromosome": "3", "start_pos": 121541479, "end_pos": 121540129, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000683498.1", "url": "https://www.ensembl.org/id/ENST00000683498.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000507534.1", "url": "https://www.ensembl.org/id/ENSP00000507534.1" } ] } }, { "isoform_ac": "O75417-1", "url": "", "sequence": { "sequence": "MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPTVPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRHFSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYITRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGNSIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIAREFYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGRAGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIVGGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEASDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFEDWTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFKSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV", "length": 2590, "header": "sp|O75417-1|DPOLQ_HUMAN Isoform 1 of DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=1 SV=2 CANONICAL=O75417-1" }, "locus": { "chromosome": "3", "start_pos": 121545877, "end_pos": 121432307, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000264233.6", "url": "https://www.ensembl.org/id/ENST00000264233.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000264233.5", "url": "https://www.ensembl.org/id/ENSP00000264233.5" } ] } }, { "isoform_ac": "O75417-2", "url": "", "sequence": { "sequence": "MNSFLSFPISLCSARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNPCALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLNKSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFSQKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCEDPFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTGSQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQSHEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDISRTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFEDSFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQHPLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDSQLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLVKEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSEMDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKLTGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQEVISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPIPTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPISDTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIRSLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKEQKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGISLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEHSGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECESQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGSTRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCLNPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPMGRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILAHLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYRKAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKRKLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGASWGELKDFDV", "length": 1762, "header": "sp|O75417-2|DPOLQ_HUMAN Isoform 2 of DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=1 SV=2 CANONICAL=O75417-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1089, "start_aa": "Thr", "end_pos": 1089, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1089", "evidence": [ { "id": "O75417", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75417" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "29208956", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29208956" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "O75417", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O75417" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1660, "start_aa": "Ser", "end_pos": 1660, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1660", "evidence": [ { "id": "O75417", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75417" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "29208956", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29208956" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" }, { "id": "O75417", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O75417" } ] } ], "phosphorylation": [ { "start_pos": 1260, "end_pos": 1260, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75417", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75417" }, { "database": "PubMed", "id": "18452278", "url": "https://glygen.org/publication/PubMed/18452278" } ], "site_lbl": "Ser1260" }, { "start_pos": 1289, "end_pos": 1289, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1289" }, { "start_pos": 1482, "end_pos": 1482, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1482" }, { "start_pos": 1486, "end_pos": 1486, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1486" }, { "start_pos": 1488, "end_pos": 1488, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1488" }, { "start_pos": 1493, "end_pos": 1493, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1493" }, { "start_pos": 1555, "end_pos": 1555, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1555" }, { "start_pos": 1563, "end_pos": 1563, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1563" }, { "start_pos": 1628, "end_pos": 1628, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1628" }, { "start_pos": 1635, "end_pos": 1635, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Ser1635" }, { "start_pos": 1651, "end_pos": 1651, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75417", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75417" }, { "database": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" } ], "site_lbl": "Ser1651" }, { "start_pos": 1755, "end_pos": 1755, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "site_lbl": "Thr1755" }, { "start_pos": 176, "end_pos": 176, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75417", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75417" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" } ], "site_lbl": "Ser176" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase.", "journal": "Genomics", "date": "1999", "authors": "Sharief FS, Vojta PJ, Ropp PA, Copeland WC", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "10395804", "url": "https://glygen.org/publication/PubMed/10395804" } ] }, { "title": "Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Lavrik OI, Prasad R, Sobol RW, Horton JK, Ackerman EJ, Wilson SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5685939", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5685939" } ], "reference": [ { "type": "PubMed", "id": "11340072", "url": "https://glygen.org/publication/PubMed/11340072" } ] }, { "title": "DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Prasad R, Lavrik OI, Kim SJ, Kedar P, Yang XP, Vande Berg BJ, Wilson SH", "evidence": [ { "database": "Reactome", "id": "R-HSA-5685939", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5685939" } ], "reference": [ { "type": "PubMed", "id": "11440997", "url": "https://glygen.org/publication/PubMed/11440997" } ] }, { "title": "DNA polymerase theta purified from human cells is a high-fidelity enzyme.", "journal": "Journal of molecular biology", "date": "2002", "authors": "Maga G, Shevelev I, Ramadan K, Spadari S, Hubscher U", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" } ], "reference": [ { "type": "PubMed", "id": "12051913", "url": "https://glygen.org/publication/PubMed/12051913" } ] }, { "title": "POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells.", "journal": "Nucleic acids research", "date": "2003", "authors": "Seki M, Marini F, Wood RD", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" }, { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" } ], "reference": [ { "type": "PubMed", "id": "14576298", "url": "https://glygen.org/publication/PubMed/14576298" } ] }, { "title": "DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers.", "journal": "International journal of cancer", "date": "2004", "authors": "Kawamura K, Bahar R, Seimiya M, Chiyo M, Wada A, Okada S, Hatano M, Tokuhisa T, Kimura H, Watanabe S, Honda I, Sakiyama S, Tagawa M, O-Wang J", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" } ], "reference": [ { "type": "PubMed", "id": "14735462", "url": "https://glygen.org/publication/PubMed/14735462" } 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Zhang Y, Maizels N", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "32873648", "url": "https://glygen.org/publication/PubMed/32873648" } ] }, { "title": "Human DNA polymerase theta harbors DNA end-trimming activity critical for DNA repair.", "journal": "Molecular cell", "date": "2021", "authors": "Zahn KE, Jensen RB, Wood RD, Doublie S", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "33577776", "url": "https://glygen.org/publication/PubMed/33577776" } ] }, { "title": "Pol\u03b8 reverse transcribes RNA and promotes RNA-templated DNA repair.", "journal": "Science advances", "date": "2021-06", "authors": "Chandramouly Gurushankar, Zhao Jiemin, McDevitt Shane, Rusanov Timur, Hoang Trung, Borisonnik Nikita, Treddinick Taylor, Lopezcolorado Felicia Wednesday, Kent Tatiana, Siddique Labiba A, Mallon Joseph, Huhn Jacklyn, Shoda Zainab, Kashkina Ekaterina, Brambati Alessandra, Stark Jeremy M, Chen Xiaojiang S, Pomerantz Richard T", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "34117057", "url": "https://glygen.org/publication/PubMed/34117057" } ] }, { "title": "Pol\u03b8 inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance.", "journal": "Nature communications", "date": "2021-06-17", "authors": "Zatreanu Diana, Robinson Helen M R, Alkhatib Omar, Boursier Marie, Finch Harry, Geo Lerin, Grande Diego, Grinkevich Vera, Heald Robert A, Langdon Sophie, Majithiya Jayesh, McWhirter Claire, Martin Niall M B, Moore Shaun, Neves Joana, Rajendra Eeson, Ranzani Marco, Schaedler Theresia, Stockley Martin, Wiggins Kimberley, Brough Rachel, Sridhar Sandhya, Gulati Aditi, Shao Nan, Badder Luned M, Novo Daniela, Knight Eleanor G, Marlow Rebecca, Haider Syed, Callen Elsa, Hewitt Graeme, Schimmel Joost, Prevo Remko, Alli Christina, Ferdinand Amanda, Bell Cameron, Blencowe Peter, Bot Chris, Calder Mathew, Charles Mark, Curry Jayne, Ekwuru Tennyson, Ewings Katherine, Krajewski Wojciech, MacDonald Ellen, McCarron Hollie, Pang Leon, Pedder Chris, Rigoreau Laurent, Swarbrick Martin, Wheatley Ed, Willis Simon, Wong Ai Ching, Nussenzweig Andre, Tijsterman Marcel, Tutt Andrew, Boulton Simon J, Higgins Geoff S, Pettitt Stephen J, Smith Graeme C M, Lord Christopher J", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "34140467", "url": "https://glygen.org/publication/PubMed/34140467" } ] }, { "title": "A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors.", "journal": "Nature cancer", "date": "2021-06", "authors": "Zhou Jia, Gelot Camille, Pantelidou Constantia, Li Adam, Y\u00fccel Hatice, Davis Rachel E, F\u00e4rkkil\u00e4 Anniina, Kochupurakkal Bose, Syed Aleem, Shapiro Geoffrey I, Tainer John A, Blagg Brian S J, Ceccaldi Raphael, D'Andrea Alan D", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "34179826", "url": "https://glygen.org/publication/PubMed/34179826" } ] }, { "title": "POLtheta-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis.", "journal": "Nature cell biology", "date": "2021", "authors": "Llorens-Agost M, Ensminger M, Le HP, Gawai A, Liu J, Cruz-Garcia A, Bhetawal S, Wood RD, Heyer WD, Lobrich M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5685939", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5685939" } ], "reference": [ { "type": "PubMed", "id": "34616022", "url": "https://glygen.org/publication/PubMed/34616022" } ] }, { "title": "Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases nu and theta in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu Y, Zhu X, Wang Z, Dai X, You C", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" } ], "reference": [ { "type": "PubMed", "id": "35815634", "url": "https://glygen.org/publication/PubMed/35815634" } ] }, { "title": "POLQ seals post-replicative ssDNA gaps to maintain genome stability in BRCA-deficient cancer cells.", "journal": "Molecular cell", "date": "2022-12-15", "authors": "Belan Ondrej, Sebald Marie, Adamowicz Marek, Anand Roopesh, Vancevska Aleksandra, Neves Joana, Grinkevich Vera, Hewitt Graeme, Segura-Bayona Sandra, Bellelli Roberto, Robinson Helen M R, Higgins Geoff S, Smith Graeme C M, West Stephen C, Rueda David S, Boulton Simon J", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "36455556", "url": "https://glygen.org/publication/PubMed/36455556" } ] }, { "title": "[Study on enhanced sensitivity to DNA damage in POLQ knocking-down salivary of adenoid cystic carcinoma-83 cells].", "journal": "Shanghai kou qiang yi xue = Shanghai journal of stomatology", "date": "2023-04", "authors": "Bai Han, Liu Han, Zhu Lei, Liu Chao, Xiao Jing", "evidence": [ { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" } ], "reference": [ { "type": "PubMed", "id": "37153990", "url": "https://glygen.org/publication/PubMed/37153990" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75417", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75417" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "RHINO directs MMEJ to repair DNA breaks in mitosis.", "journal": "Science (New York, N.Y.)", "date": "2023-08-11", "authors": "Brambati Alessandra, Sacco Olivia, Porcella Sarina, Heyza Joshua, Kareh Mike, Schmidt Jens C, Sfeir Agnel", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "reference": [ { "type": "PubMed", "id": "37440612", "url": "https://glygen.org/publication/PubMed/37440612" } ] }, { "title": "Pol\u03b8 is phosphorylated by PLK1 to repair double-strand breaks in mitosis.", "journal": "Nature", "date": "2023-09", "authors": "Gelot Camille, Kovacs Marton Tibor, Miron Simona, Mylne Emilie, Haan Alexis, Boeffard-Dosierre Liza, Ghouil Rania, Popova Tatiana, Dingli Florent, Loew Damarys, Guirouilh-Barbat Jos\u00e9e, Del Nery Elaine, Zinn-Justin Sophie, Ceccaldi Raphael", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" }, { "database": "RefSeq", "id": "NP_955452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_955452" } ], "reference": [ { "type": "PubMed", "id": "37674080", "url": "https://glygen.org/publication/PubMed/37674080" } ] }, { "title": "Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage.", "journal": "Biochemistry", "date": "1994", "authors": "Satoh MS, Poirier GG, Lindahl T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5685939", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5685939" } ], "reference": [ { "type": "PubMed", "id": "8003475", "url": "https://glygen.org/publication/PubMed/8003475" } ] }, { "title": "Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).", "journal": "The EMBO journal", "date": "1997", "authors": "Klungland A, Lindahl T", "evidence": [ { "database": "Reactome", "id": "R-HSA-5685939", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5685939" } ], "reference": [ { "type": "PubMed", "id": "9214649", "url": "https://glygen.org/publication/PubMed/9214649" } ] } ], "pathway": [ { "id": "hsa:10721", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10721", "resource": "KEGG Pathway" }, { "id": "R-HSA-5685939", "name": "HDR through MMEJ (alt-NHEJ)", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5685939", "resource": "Reactome", "description": "HDR through MMEJ (alt-NHEJ)" } ], "orthologs": [ { "uniprot_canonical_ac": "D4A628-1", "protein_name": "DNA polymerase theta", "gene_name": "Polq", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLPRRSGKRRRSSSGSDSFSFSGDGDSCVSPQLLCRPVLSPPPGLGRGRRLAGTGTCKQRVSDDQIDQLLLANWGLPKAVLEKYHNFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAGKTLVAELLILKRVLETRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPTGRFSSLDVAVCTIERANGLINRLIEENKMDLLGTVVVDELHMLGDSHRGYLLELLLTKVCFVTRKSASCQADSASALACAVQIVGMSATLPNLQLVASWLNAELYHTDFRPVPLLESIKVGNSIYDSSMKLVREFQPLLQVKGDEDHIVSLCYETVRDNHSVLVFCPSKKWCEKVADIIAREFYNLHHQPEGLVKSSEFPPVILDQKSLLEVIDQLKRSPSGLDSVLKNTVPWGVAFHHAGLTFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPVFGGQPLDILTYKQMVGRAGRKGVDTMGESILVCKNSEKSKGIALLQGSLEPVHSCLQSQGEVTSTMIRAILEIIVSGVASTSQDMQTYAACTFLAADVKEGKQGIQRNRDDVQRGAVDACVTWLLENEFIQAAEPSDGTGGKVYHPTHLGSATLSSSLSPTDTLDIFADLQRAMKGFVLENDLHIVYLVTPVFEDWTSIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEIPLKEINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLIRVSSLNAQRARFLYASGFLTVADLARADTVEVEAALKDALPFKSARKAVDEEEEAAEERRSMRTIWVAGKSLSAREAAALIVEEAKVILQQDLIEMGVQWGPHSPLSSSTHSLTSGSEVKEHTFKSQTKSSHKRLASKSRNSMRVSGSNGKQSPEAGQGLDECRERPDSLCKFQGNHEIQTPSVYRARKRTSLGVNKEMLRTSLKEGKPSTKEVLQTLSFEKTRKAALSFSSEQANNSFPSGRDRKYRKKSWGSSPMSDSVMHRDDLQGQTMCKSTLCEDPQKSLEEQNTEYRSPGLFAKNVSFCAKEKCNKTSFPLQMQQPCLRRKPESGAAVDHSVAVSQNKNVVEQPPGAPRDRRGLAAHGRAEVNEVLTENGTESQLHDTHPVSQCLENHSEKQTNTCTRQKTLTEGQAGISHVTRGSNDLTPIRCERLKLNSKEHDSNPCPQALGTNAGRTEAPQSSEALGQAGGQCENLLNSPGIQEKTSAHATNKTEHSHVANQAFCDFGDSLYLDTQSEEIIEQMATKNATQGAEAAGITEEGSATQNEPHSTTGGQHIPGAANTDHVDRKNTESVKENPEKNIDRRTPHSLIFHSPTPQGGNSACFKENEHSVTDSQLNSFLQGLETQDKPIIPLAPQMRTSTGVEEESLPETSLNMSDSILFDSFGEDSFGQRQSLDVKAKQPLLSEMTPNHFHNPPYPQEDPVMTPHMSEPQGTLERMACLSGESIIFSEIDSAQVIEALDNMAAFYMQENCNPITLKTEPRDLAALGNECPQGEVVRGEQHEGSSKPKFMEINQDNSFTWSAASFNLSPELQRILDKVSTPRENEEPELMHADLSCFEENSTESHERQDMNSDLGTVQRTSFLPSNGVKSRTEGLESKAKHGGASSALPHKAAADDNGLIPPTPLPASASASASKLALPEILGTSVKHQKASCLFDSPSDNQNQDLSQELRDSLKDSDGSVVDTSFFLQSQDGLLLTQASCSSESLAIIDVASDQILFQTFVKEWQCQKRFSISLACEKMTSSTSSKTATIGGRLKQVNSPQEASVEDDGFPVHGSDCAVVVGLAVCWGGKDAYYLSLQKEQKQSEMSPSLAPPPLDATLTVKERMEYLQSCLQKKSDQERSVVTYDFIQTYKVLLLSCGISLEPSYEDPKVACWLLDPDSKEPTLHSIVTSFLPHELALLEGIETGPGIQSLGLNVNTDHSGRYRASVESVLIFNSMNQLNSMLQKENLHDIFCKVEMPSQYCLALLELNGIGFSTAECETQKHIMQAKLDAIETQAYQLAGHSFSFTSADDIAQVLFLELKLPPNGEMKTQGGRKTLGSTRRGTESDRKLRLGRRFSTSKDILNKLKDLHPLPGLILEWRRISNAITKVVFPLQREKHLNPFLRMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVRESPPSQASGKGQLAMARQNQKVYGLHPGQRTVLEKTSDRGVPFSVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDCRLIQVLNSGADVFRSIAAEWKMIEPDAVGDNLRQQAKQICYGIIYGMGAKSLGEQMGIKENDAACYIDSFKSRYKGINHFMRDTVKNCRRDGFVETILGRRRYLPGIKDNNPYHKAHAERQAINTTVQGSAADIVKVATVNIQKQLETFHPTFKSHGHRESMLQSDRAGLLPKRKVKGMFCPMRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMECAIKLSVKLKVKVKIGASWGELKDFDV", "length": 2547 }, "evidence": [ { "id": "45932422", "url": "http://www.informatics.jax.org/homology/45932422", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8CGS6-1", "protein_name": "DNA polymerase theta", "gene_name": "Polq", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSLPRRSRKRRRSSSGSDTFSGDGDSFVSPQLRCGPVLSPPPGLGRGRRLTGTGTNKRRVSDDQIDQLLLANWGLPKAVLEKYHSFGVRKMFEWQAECLLLGHVLEGKNLVYSAPTSAGKTLVAELLILKRVLETRKKALFILPFVSVAKEKKCYLQSLFQEVGLKVDGYMGSTSPTGQFSSLDIAVCTIERANGLVNRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYVTRKSASHQAESASTLSNAVQIVGMSATLPNLQLVASWLNAELYHTDFRPVPLLESIKIGNSIYDSSMKLVREFQPLLQVKGDEDHIVSLCYETIQDNHSVLIFCPSKKWCEKVADIIAREFYNLHHQPEGLVKSSEFPPVILDQKSLLEVMDQLKRSPSGLDSVLKNTVPWGVAFHHAGLTFEERDIIEGAFRQGFIRVLAATSTLSSGVNLPARRVIIRTPIFSGQPLDILTYKQMVGRAGRKGVDTMGESILVCKNSEKSKGIALLQGSLEPVHSCLQRQGEVTASMIRAILEIIVGGVASTSQDMQTYAACTFLAAAIQEGKQGMQRNQDDAQLGAIDACVTWLLENEFIQVAEPGDGTGGKVYHPTHLGSATLSSSLSPTDTLDIFADLQRAMKGFVLENDLHIVYLVTPVFEDWISIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFFTSLVLLDLISEIPLKDINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQFQKRLTFGIQRELCDLIRVSLLNAQRARFLYASGFLTVADLARADSAEVEVALKNSLPFKSARKAVDEEEEAAEERRSMRTIWVTGKGLSAREAAALIVEEAKMILQQDLIEMGVRWDPKSPLSSSTHSRTSTSEVKEHTFKSQTKSSHKRLASMGRNSIRASGSNDKPSPDAERGIDDCSEHADSLCKFQGNFEPQTPSICTARKRTSLGINKEMLRKSLKEGKPSTKEVLQTFSSEKTRKTALSFSSEQVNNTLPSGRDRKYQKKSWGSSPVRDSGMHRGDLQGQTMCTSALCEDSQKSLEEQNAEFRSPGLFAKHLPSCAKEKCKKPSLPLQRQQACSRRSTESCAAVGHPAAGSSPAAARDRRGLAARETEKGNEALTENGGESQLQDTYPVSQYLEYHSEKHTNTCTRQKTLTEGQAGSSYVARDSNDAAPIKCERMKLNSKDRDSNPCRQALGSYTGRTEALQSTAKLGQAGGQCENLLNSSGVQGKTGAHATNRTEHSHASNPAFCDFGDSLDLDTQSEEIIEQMATENTMQGAKAVVIMEEGSAMQNKCHSTPGDQHVPGAANTDHVDSKKVESVKANTEKNINRGAPVSLIFHTQGENGACFKGNEHSVTDSQLNSFLQGFETQEIVKPIIPLAPQMRTPTGVEEESLPETSLNMSDSILFDSFGEDGFGQGQSPDIKANQPLLSEMTPNHFSNPPHPQEDPVMTPTVSEPQGTQQQGVCLSGESIIFSDIDSAQVIEALDNMAAFHVQENCNSVALKTLEPSDSAVLGNECPQGKLVRGDQNEGSPKPKLTETNQDNSFTWSGASFNLSPELQRILDKVSSPRENEKPKMIHVNLSSFEGNSKESHEREEINSDLGTVQRTSVFPSNEVKNRTEGLESKARHGGASSPLPRKESAAADDNGLIPPTPVPASASKVAFPEILGTSVKRQKASSALQPGESCLFGSPSDNQNQDLSQELRDSLKDYDGSVADTSFFLQSQDGLLLTQASCSSESLAIIDVASDQILFQTFVKEWQCQKRFSISLACEKMTSSMSSKTATIGGKLKQVSLPQEATVEDAGFPVRGCDGAVVVGLAVCWGAKDAYYLSLQKEQKQSEISPSLAPPPLDATLTVKERMECLQSCLQKKSDRERSVVTYDFIQTYKVLLLSCGISLEPSYEDPKVACWLLDPDSKEPTLHSIVTSFLPHELALLEGMETGPGIQSLGLNVNTEHSGRYRASVESVLIFNSMNQLNSLLQKENLHDIFCKVEMPSQYCLALLELNGIGFSTAECESQKHVMQAKLDAIETQAYQLAGHSFSFTSADDIAQVLFLELKLPPNGEMKTQGSKKTLGSTRRGNESGRRMRLGRQFSTSKDILNKLKGLHPLPGLILEWRRISNAITKVVFPLQREKHLNPLLRMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVRESPPSQAPKGRFPMAIGQDKKVYGLHPGHRTQMEEKASDRGVPFSVSMRHAFVPFPGGLILAADYSQLELRILAHLSRDCRLIQVLNTGADVFRSIAAEWKMIEPDAVGDDLRQHAKQICYGIIYGMGAKSLGEQMGIKENDAASYIDSFKSRYKGINHFMRDTVKNCRKNGFVETILGRRRYLPGIKDDNPYHKAHAERQAINTTVQGSAADIVKIATVNIQKQLETFRSTFKSHGHRESMLQNDRTGLLPKRKLKGMFCPMRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMECAIKLSVKLKVKVKIGASWGELKDFDV", "length": 2544 }, "evidence": [ { "id": "45932422", "url": "http://www.informatics.jax.org/homology/45932422", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 11, "go_terms": [ { "name": "DNA-directed DNA polymerase activity", "id": "GO:0003887", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003887", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "5'-deoxyribose-5-phosphate lyase activity", "id": "GO:0051575", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051575", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "RNA-directed DNA polymerase activity", "id": "GO:0003964", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003964", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "magnesium ion binding", "id": "GO:0000287", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000287", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "chromatin binding", "id": "GO:0003682", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "damaged DNA binding", "id": "GO:0003684", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003684", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "DNA helicase activity", "id": "GO:0003678", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003678", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "single-stranded DNA endodeoxyribonuclease activity", "id": "GO:0000014", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000014", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "single-stranded DNA helicase activity", "id": "GO:0017116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017116", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "double-strand break repair via alternative nonhomologous end joining", "id": "GO:0097681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097681", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "DNA repair", "id": "GO:0006281", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006281", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "protein homooligomerization", "id": "GO:0051260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051260", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "base-excision repair", "id": "GO:0006284", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006284", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "DNA damage response", "id": "GO:0006974", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "double-strand break repair", "id": "GO:0006302", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "somatic hypermutation of immunoglobulin genes", "id": "GO:0016446", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016446", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "error-prone translesion synthesis", "id": "GO:0042276", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042276", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "replication fork processing", "id": "GO:0031297", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031297", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "site of double-strand break", "id": "GO:0035861", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" }, { "name": "site of DNA damage", "id": "GO:0090734", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090734", "evidence": [ { "database": "UniProtKB", "id": "O75417", "url": "https://www.uniprot.org/uniprot/O75417" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1100, "end_pos": 1102, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1110, "end_pos": 1112, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1121, "end_pos": 1123, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1125, "end_pos": 1127, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1145, "end_pos": 1147, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1175, "end_pos": 1177, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1232, "end_pos": 1234, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1287, "end_pos": 1289, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1301, "end_pos": 1303, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1484, "end_pos": 1486, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1582, "end_pos": 1584, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1626, "end_pos": 1628, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1664, "end_pos": 1666, "annotation": "n_glycosylation_sequon" }, { "start_pos": 337, "end_pos": 339, "annotation": "n_glycosylation_sequon" }, { "start_pos": 938, "end_pos": 940, "annotation": 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"Q9W4W2-1" ], "evidence": [ { "id": "13065", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/13065" } ] }, { "id": "22508", "name": "", "equation": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q673L6-1", "Q5RKI3-1", "O54747-1", "O89042-1", "P06766-1", "Q9QYV8-1", "D3Z8X4-1", "E9PT58-1", "F1M8G6-1", "F7F6Z7-1", "Q07864-1", "P28340-1", "P06746-1", "Q9UGP5-1", "P54098-1", "Q9NP87-1", "P09884-1", "Q7Z5Q5-1", "O75417-1", "O00370-1", "Q9WJR5-1", "Q9UBT6-1", "O60673-1", "Q9UNA4-1", "Q9Y253-1", "P63135-1", "P10266-1", "P63132-1", "P63133-1", "P63136-1", "Q9UQG0-1", "Q9QC07-1", "P63128-1", "Q9BXR3-1", "P04053-1", "O14746-1", "P10400-1", "P11369-1", "P52431-1", "Q7TQ07-1", "Q9JIW4-1", "P54099-1", "Q8K409-1", "P33609-1", "Q9WVF7-1", "Q9QXE2-1", "Q8CGS6-1", "Q61493-1", "O70372-1", "P09838-2", "Q6R3M4-1", "Q9JJN0-1", "Q9QUG2-1", "P13382-1", "P14284-1", "P15436-1", "P15801-1", "P21951-1", "P25384-1", "P25615-1", "P46957-1", "Q04049-1", "Q06163-1", "A0A0B7P3V8-1", "O13527-1", "O13535-1", "P0C2I2-1", "P0C2I3-1", "P0C2I5-1", "P0C2I6-1", "P0C2I9-1", "P0C2J0-1", "P0C2J1-1", "P0C2J3-1", "P0C2J7-1", "P0CX63-1", "P0CX64-1", "Q99231-1", "P39985-1", "P47024-1", "P47098-1", "P47100-1", "Q12472-1", "Q03434-1", "Q03494-1", "Q03612-1", "Q03619-1", "Q03855-1", "Q04214-1", "Q04670-1", "Q04711-1", "Q07791-1", "Q07793-1", "Q12088-1", "Q12112-1", "Q12113-1", "Q12141-1", "Q12193-1", "Q12269-1", "Q12273-1", "Q12316-1", "Q12414-1", "Q12490-1", "Q12491-1", "Q12501-1", "Q7LHG5-1", "Q92393-1", "Q99315-1", "Q99337-1", "Q55AZ3-1", "Q1ZXF2-1", "Q54B44-1", "Q54N97-1", "Q54RD4-1", "Q54SV8-1", "Q9GSR1-1", "Q9VHV1-1", "Q9VNX1-1", "Q9VCN1-1", "P26019-1", "P54358-1", "Q27607-1", "O18475-1" ], "evidence": [ { "id": "22508", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22508" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A096MJV7", "gene_name": "Chd9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A096MJV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A096MJV7" } ] } ] }, { "uniprot_ac": "A0A0B7P3V8", "gene_name": "TY4B-P", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "A0A0B7P3V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B7P3V8" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "A0A0B7P3V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B7P3V8" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "A0A0B7P3V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B7P3V8" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "A0A0B7P3V8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0B7P3V8" } ] } ] }, { "uniprot_ac": "A0A0G2JTM6", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2JTM6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JTM6" } ] } ] }, { "uniprot_ac": "A0A0G2K0E0", "gene_name": "Ddx56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K0E0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0E0" } ] } ] }, { "uniprot_ac": "A0A0G2K0H9", "gene_name": "Ruvbl1-ps1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0H9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2K0H9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0H9" } ] } ] }, { "uniprot_ac": "A0A0G2K283", "gene_name": "Dhx8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K283" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K283" } ] } ] }, { "uniprot_ac": "A0A0G2K4S4", "gene_name": "Ddx51", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K4S4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A0G2K4S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K4S4" } ] } ] }, { "uniprot_ac": "A0A0G2KA92", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A0G2KA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KA92" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A0G2KA92", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2KA92" } ] } ] }, { "uniprot_ac": "A0A7N9VSG0", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A7N9VSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A7N9VSG0" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "A0A7N9VSG0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A7N9VSG0" } ] } ] }, { "uniprot_ac": "A0A8I5ZKH1", "gene_name": "Ythdc2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKH1" } ] } ] }, { "uniprot_ac": "A0A8I5ZKV9", "gene_name": "Ddx5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKV9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKV9" } ] } ] }, { "uniprot_ac": "A0A8I5ZKX7", "gene_name": "Ddx47", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZKX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKX7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZKX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZKX7" } ] } ] }, { "uniprot_ac": "A0A8I5ZZZ0", "gene_name": "Ddx31", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I5ZZZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I5ZZZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZZZ0" } ] } ] }, { "uniprot_ac": "A0A8I6ABZ7", "gene_name": "Dhx9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6ABZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6ABZ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ABZ7" } ] } ] }, { "uniprot_ac": "A0A8I6AFW4", "gene_name": "Ddx24", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6AFW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFW4" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6AFW4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFW4" } ] } ] }, { "uniprot_ac": "A0A8I6AK63", "gene_name": "ENSRNOG00000069014", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6AK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK63" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6AK63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK63" } ] } ] }, { "uniprot_ac": "A0A8I6GF11", "gene_name": "Eif4a1-ps8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GF11" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A0A8I6GF11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GF11" } ] } ] }, { "uniprot_ac": "A0A8I6GIN4", "gene_name": "AC129365.1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIN4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6GIN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIN4" } ] } ] }, { "uniprot_ac": "A0A8I6GIY0", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A0A8I6GIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIY0" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A0A8I6GIY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GIY0" } ] } ] }, { "uniprot_ac": "A1Z9L3", "gene_name": "pea", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A1Z9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9L3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A1Z9L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1Z9L3" } ] } ] }, { "uniprot_ac": "A2A4P0", "gene_name": "Dhx8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2A4P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A4P0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A2A4P0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A4P0" } ] } ] }, { "uniprot_ac": "A2A8L1", "gene_name": "Chd5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2A8L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A2A8L1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L1" } ] } ] }, { "uniprot_ac": "A2ACQ1", "gene_name": "Dhx35", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2ACQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ACQ1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A2ACQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ACQ1" } ] } ] }, { "uniprot_ac": "A2AJK6", "gene_name": "Chd7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2AJK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJK6" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A2AJK6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJK6" } ] } ] }, { "uniprot_ac": "A2PYH4", "gene_name": "HFM1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A2PYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2PYH4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A2PYH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2PYH4" } ] } ] }, { "uniprot_ac": "A3KFM7", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A3KFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KFM7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A3KFM7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A3KFM7" } ] } ] }, { "uniprot_ac": "A6KSS8", "gene_name": "Mcm7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A6KSS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KSS8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "A6KSS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6KSS8" } ] } ] }, { "uniprot_ac": "A6NHR9", "gene_name": "SMCHD1", "activity": [ { "ec_number": "3.6.1.-", "activity": "", "evidence": [ { "id": "A6NHR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NHR9" } ] } ] }, { "uniprot_ac": "A8DZ26", "gene_name": "anne", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "A8DZ26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8DZ26" } ] } ] }, { "uniprot_ac": "A8MPP1", "gene_name": "DDX11L8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "A8MPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8MPP1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "A8MPP1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8MPP1" } ] } ] }, { "uniprot_ac": "B0G0Y4", "gene_name": "wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B0G0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B0G0Y4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G0Y4" } ] } ] }, { "uniprot_ac": "B1AR17", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B1AR17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AR17" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B1AR17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AR17" } ] } ] }, { "uniprot_ac": "B2GUX3", "gene_name": "Mcm5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "B2GUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GUX3" } ] } ] }, { "uniprot_ac": "B2RR83", "gene_name": "Ythdc2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "B2RR83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RR83" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "B2RR83", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RR83" } ] } ] }, { "uniprot_ac": "D3Z0M9", "gene_name": "Ddx23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z0M9" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3Z0M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z0M9" } ] } ] }, { "uniprot_ac": "D3Z4R1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z4R1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z4R1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z4R1" } ] } ] }, { "uniprot_ac": "D3Z8X4", "gene_name": "Pole", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "D3Z8X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X4" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "D3Z8X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z8X4" } ] } ] }, { "uniprot_ac": "D3Z9Z9", "gene_name": "Smarcad1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3Z9Z9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9Z9" } ] } ] }, { "uniprot_ac": "D3ZA12", "gene_name": "Chd6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZA12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZA12" } ] } ] }, { "uniprot_ac": "D3ZAP7", "gene_name": "Chd7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZAP7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZAP7" } ] } ] }, { "uniprot_ac": "D3ZBY5", "gene_name": "Ddx10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZBY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBY5" } ] } ] }, { "uniprot_ac": "D3ZD32", "gene_name": "Chd5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZD32", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD32" } ] } ] }, { "uniprot_ac": "D3ZD46", "gene_name": "Dhx58", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD46" } ] } ] }, { "uniprot_ac": "D3ZD97", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZD97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD97" } ] } ] }, { "uniprot_ac": "D3ZEG9", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZEG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZEG9" } ] } ] }, { "uniprot_ac": "D3ZFP4", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZFP4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZFP4" } ] } ] }, { "uniprot_ac": "D3ZG52", "gene_name": "Dna2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZG52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZG52" } ] } ] }, { "uniprot_ac": "D3ZH42", "gene_name": "Mov10l1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZH42" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZH42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZH42" } ] } ] }, { "uniprot_ac": "D3ZHW0", "gene_name": "Dhx29", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZHW0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZHW0" } ] } ] }, { "uniprot_ac": "D3ZP96", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZP96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP96" } ] } ] }, { "uniprot_ac": "D3ZQW1", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZQW1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQW1" } ] } ] }, { "uniprot_ac": "D3ZSV6", "gene_name": "Dhx33", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZSV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZSV6" } ] } ] }, { "uniprot_ac": "D3ZUC2", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZUC2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZUC2" } ] } ] }, { "uniprot_ac": "D3ZVK1", "gene_name": "Mcm8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D3ZVK1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVK1" } ] } ] }, { "uniprot_ac": "D3ZX56", "gene_name": "Ddx55", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D3ZX56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZX56" } ] } ] }, { "uniprot_ac": "D4A1R0", "gene_name": "Dhx37", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A1R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1R0" } ] } ] }, { "uniprot_ac": "D4A2B7", "gene_name": "Afg2b", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "D4A2B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2B7" } ] } ] }, { "uniprot_ac": "D4A2Z8", "gene_name": "Dhx36", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A2Z8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A2Z8" } ] } ] }, { "uniprot_ac": "D4A321", "gene_name": "Dhx38", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A321" } ] } ] }, { "uniprot_ac": "D4A523", "gene_name": "Nlrp3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A523" } ] } ] }, { "uniprot_ac": "D4A6Q6", "gene_name": "Ino80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "D4A6Q6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A6Q6" } ] } ] }, { "uniprot_ac": "D4A7Q5", "gene_name": "Ddx28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7Q5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4A7Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7Q5" } ] } ] }, { "uniprot_ac": "D4AAG9", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4AAG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AAG9" } ] } ] }, { "uniprot_ac": "D4ACP5", "gene_name": "Recql5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "D4ACP5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ACP5" } ] } ] }, { "uniprot_ac": "D4ADT5", "gene_name": "Rig1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "D4ADT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT5" } ] } ] }, { "uniprot_ac": "E9PT58", "gene_name": "Dntt", "activity": [ { "ec_number": "2.7.7.31", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "E9PT58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT58" } ] }, { "ec_number": "2.7.7.31", "activity": "", "evidence": [ { "id": "E9PT58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT58" } ] } ] }, { "uniprot_ac": "E9PU01", "gene_name": "Chd4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PU01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PU01" } ] } ] }, { "uniprot_ac": "E9PZJ8", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PZJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZJ8" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PZJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZJ8" } ] } ] }, { "uniprot_ac": "E9PZM4", "gene_name": "Chd2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9PZM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZM4" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "E9PZM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PZM4" } ] } ] }, { "uniprot_ac": "E9Q555", "gene_name": "Rnf213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "E9Q555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q555" } ] } ] }, { "uniprot_ac": "E9QAM5", "gene_name": "Helz2", "activity": [ { "ec_number": "3.1.13.1", "activity": "Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] }, { "ec_number": "3.1.13.1", "activity": "", "evidence": [ { "id": "E9QAM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9QAM5" } ] } ] }, { "uniprot_ac": "F1LNJ2", "gene_name": "Snrnp200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LNJ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNJ2" } ] } ] }, { "uniprot_ac": "F1LPQ2", "gene_name": "Ascc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LPQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPQ2" } ] } ] }, { "uniprot_ac": "F1LTH9", "gene_name": "Wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LTH9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTH9" } ] } ] }, { "uniprot_ac": "F1LTR3", "gene_name": "Tdrd12", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "F1LTR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LTR3" } ] } ] }, { "uniprot_ac": "F1LWY1", "gene_name": "Hfm1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1LWY1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LWY1" } ] } ] }, { "uniprot_ac": "F1M298", "gene_name": "Fbh1", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "F1M298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M298" } ] } ] }, { "uniprot_ac": "F1M5F3", "gene_name": "Mcm9", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "F1M5F3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M5F3" } ] } ] }, { "uniprot_ac": "F1M8G6", "gene_name": "Rev3l", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "F1M8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8G6" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "F1M8G6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M8G6" } ] } ] }, { "uniprot_ac": "F1M9L4", "gene_name": "Atp13a4", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1M9L4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M9L4" } ] } ] }, { "uniprot_ac": "F1MA70", "gene_name": "Atp13a5", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "F1MA70", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MA70" } ] } ] }, { "uniprot_ac": "F7F6Z7", "gene_name": "Polm", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "F7F6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F6Z7" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "F7F6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F6Z7" } ] } ] }, { "uniprot_ac": "F8VPZ5", "gene_name": "Ercc6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "F8VPZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F8VPZ5" } ] } ] }, { "uniprot_ac": "G3V681", "gene_name": "Mcm4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V681" } ] } ] }, { "uniprot_ac": "G3V6W5", "gene_name": "Ifih1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V6W5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6W5" } ] } ] }, { "uniprot_ac": "G3V8T5", "gene_name": "Ruvbl2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "G3V8T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V8T5" } ] } ] }, { "uniprot_ac": "G3V9M1", "gene_name": "Ddx23", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9M1" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3V9M1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9M1" } ] } ] }, { "uniprot_ac": "G3X8X0", "gene_name": "Dhx16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "G3X8X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3X8X0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "G3X8X0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3X8X0" } ] } ] }, { "uniprot_ac": "O00148", "gene_name": "DDX39A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00148" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O00148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00148" } ] } ] }, { "uniprot_ac": "O00370", "gene_name": "", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O00370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00370" } ] }, { "ec_number": "3.1.21.-", "activity": "", "evidence": [ { "id": "O00370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00370" } ] } ] }, { "uniprot_ac": "O00571", "gene_name": "DDX3X", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00571" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O00571", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00571" } ] } ] }, { "uniprot_ac": "O00835", "gene_name": "repB", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O00835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00835" } ] } ] }, { "uniprot_ac": "O08811", "gene_name": "Ercc2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O08811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08811" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O08811", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08811" } ] } ] }, { "uniprot_ac": "O09053", "gene_name": "Wrn", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O09053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09053" } ] } ] }, { "uniprot_ac": "O13527", "gene_name": "TY1B-A", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13527" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "O13527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13527" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13527", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13527" } ] } ] }, { "uniprot_ac": "O13535", "gene_name": "TY1B-H", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O13535", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13535" } ] } ] }, { "uniprot_ac": "O13559", "gene_name": "YRF1-4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O13559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13559" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O13559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O13559" } ] } ] }, { "uniprot_ac": "O14646", "gene_name": "CHD1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14646" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14646" } ] } ] }, { "uniprot_ac": "O14647", "gene_name": "CHD2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O14647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14647" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O14647", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14647" } ] } ] }, { "uniprot_ac": "O14656", "gene_name": "TOR1A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O14656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14656" } ] } ] }, { "uniprot_ac": "O14657", "gene_name": "TOR1B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O14657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14657" } ] } ] }, { "uniprot_ac": "O14746", "gene_name": "TERT", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O14746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14746" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "O14746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14746" } ] } ] }, { "uniprot_ac": "O15523", "gene_name": "DDX3Y", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O15523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15523" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O15523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15523" } ] } ] }, { "uniprot_ac": "O16102", "gene_name": "Chd3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O16102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O16102" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O16102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O16102" } ] } ] }, { "uniprot_ac": "O18475", "gene_name": "PolQ", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18475" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O18475" } ] } ] }, { "uniprot_ac": "O35286", "gene_name": "Dhx15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O35286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35286" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O35286", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35286" } ] } ] }, { "uniprot_ac": "O43143", "gene_name": "DHX15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] } ] }, { "uniprot_ac": "O43933", "gene_name": "PEX1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O43933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43933" } ] } ] }, { "uniprot_ac": "O46072", "gene_name": "kz", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O46072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46072" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O46072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46072" } ] } ] }, { "uniprot_ac": "O54747", "gene_name": "Pold1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "O54747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54747" } ] } ] }, { "uniprot_ac": "O60231", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] } ] }, { "uniprot_ac": "O60282", "gene_name": "KIF5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "O60282", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60282" } ] } ] }, { "uniprot_ac": "O60306", "gene_name": "AQR", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] } ] }, { "uniprot_ac": "O60673", "gene_name": "REV3L", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O60673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60673" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O60673", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60673" } ] } ] }, { "uniprot_ac": "O61305", "gene_name": "Dbp80", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O61305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61305" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O61305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61305" } ] } ] }, { "uniprot_ac": "O70133", "gene_name": "Dhx9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O70133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70133" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O70133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70133" } ] } ] }, { "uniprot_ac": "O70372", "gene_name": "Tert", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O70372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70372" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "O70372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70372" } ] } ] }, { "uniprot_ac": "O75351", "gene_name": "VPS4B", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75351" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "O75351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75351" } ] } ] }, { "uniprot_ac": "O75417", "gene_name": "POLQ", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O75417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75417" } ] } ] }, { "uniprot_ac": "O75643", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] } ] }, { "uniprot_ac": "O88700", "gene_name": "Blm", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O88700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88700" } ] } ] }, { "uniprot_ac": "O89042", "gene_name": "Pola1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "O89042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89042" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "O89042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89042" } ] } ] }, { "uniprot_ac": "O94761", "gene_name": "RECQL4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O94761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94761" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O94761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94761" } ] } ] }, { "uniprot_ac": "O94762", "gene_name": "RECQL5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O94762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94762" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O94762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94762" } ] } ] }, { "uniprot_ac": "O95786", "gene_name": "RIGI", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O95786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95786" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O95786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95786" } ] } ] }, { "uniprot_ac": "O97159", "gene_name": "Mi-2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O97159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97159" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "O97159", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O97159" } ] } ] }, { "uniprot_ac": "P02572", "gene_name": "Act42A", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02572" } ] } ] }, { "uniprot_ac": "P02574", "gene_name": "Act79B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P02574", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P02574" } ] } ] }, { "uniprot_ac": "P04053", "gene_name": "DNTT", "activity": [ { "ec_number": "2.7.7.31", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P04053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04053" } ] }, { "ec_number": "2.7.7.31", "activity": "", "evidence": [ { "id": "P04053", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04053" } ] } ] }, { "uniprot_ac": "P05186", "gene_name": "ALPL", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P05186", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05186" } ] } ] }, { "uniprot_ac": "P06634", "gene_name": "DED1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06634" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P06634", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06634" } ] } ] }, { "uniprot_ac": "P06746", "gene_name": "POLB", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "P06746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06746" } ] } ] }, { "uniprot_ac": "P06761", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P06761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06761" } ] } ] }, { "uniprot_ac": "P06766", "gene_name": "Polb", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "4.2.99.18", "activity": "2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+).", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "4.2.99.-", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P06766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06766" } ] } ] }, { "uniprot_ac": "P06839", "gene_name": "RAD3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P06839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06839" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P06839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06839" } ] } ] }, { "uniprot_ac": "P07271", "gene_name": "PIF1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07271" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P07271", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07271" } ] } ] }, { "uniprot_ac": "P07828", "gene_name": "act18", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07828" } ] } ] }, { "uniprot_ac": "P07829", "gene_name": "act3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07829" } ] } ] }, { "uniprot_ac": "P07830", "gene_name": "act19", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P07830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07830" } ] } ] }, { "uniprot_ac": "P07900", "gene_name": "HSP90AA1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P07900", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07900" } ] } ] }, { "uniprot_ac": "P07901", "gene_name": "Hsp90aa1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P07901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07901" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P07901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07901" } ] } ] }, { "uniprot_ac": "P08289", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P08289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08289" } ] } ] }, { "uniprot_ac": "P09052", "gene_name": "vas", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P09052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09052" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P09052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09052" } ] } ] }, { "uniprot_ac": "P09242", "gene_name": "Alpl", "activity": [ { "ec_number": "3.1.3.1", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "H2O + N-phosphocreatine = creatine + phosphate.", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.1.3.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] }, { "ec_number": "3.9.1.1", "activity": "", "evidence": [ { "id": "P09242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09242" } ] } ] }, { "uniprot_ac": "P09838", "gene_name": "Dntt", "activity": [ { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P09838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09838" } ] }, { "ec_number": "2.7.7.31", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P09838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09838" } ] }, { "ec_number": "2.7.7.31", "activity": "", "evidence": [ { "id": "P09838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09838" } ] } ] }, { "uniprot_ac": "P09884", "gene_name": "POLA1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P09884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09884" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P09884", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09884" } ] } ] }, { "uniprot_ac": "P0C2I2", "gene_name": "TY1B-DR5", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I2" } ] } ] }, { "uniprot_ac": "P0C2I3", "gene_name": "TY1B-DR6", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I3" } ] } ] }, { "uniprot_ac": "P0C2I5", "gene_name": "TY1B-LR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I5" } ] } ] }, { "uniprot_ac": "P0C2I6", "gene_name": "TY1B-LR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I6" } ] } ] }, { "uniprot_ac": "P0C2I9", "gene_name": "TY1B-PR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2I9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2I9" } ] } ] }, { "uniprot_ac": "P0C2J0", "gene_name": "TY1B-PR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J0" } ] } ] }, { "uniprot_ac": "P0C2J1", "gene_name": "TY1B-PR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J1" } ] } ] }, { "uniprot_ac": "P0C2J3", "gene_name": "TY2B-LR1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J3" } ] } ] }, { "uniprot_ac": "P0C2J7", "gene_name": "TY4B-H", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0C2J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C2J7" } ] } ] }, { "uniprot_ac": "P0CS90", "gene_name": "SSC1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CS90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CS90" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P0CS90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CS90" } ] } ] }, { "uniprot_ac": "P0CX14", "gene_name": "YRF1-3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX14" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX14" } ] } ] }, { "uniprot_ac": "P0CX15", "gene_name": "YRF1-7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX15" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX15", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX15" } ] } ] }, { "uniprot_ac": "P0CX20", "gene_name": "YRF1-1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX20" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX20" } ] } ] }, { "uniprot_ac": "P0CX21", "gene_name": "YRF1-5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX21" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX21" } ] } ] }, { "uniprot_ac": "P0CX22", "gene_name": "YRF1-8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P0CX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX22" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P0CX22", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX22" } ] } ] }, { "uniprot_ac": "P0CX63", "gene_name": "TY2B-F", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0CX63", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX63" } ] } ] }, { "uniprot_ac": "P0CX64", "gene_name": "TY2B-GR2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P0CX64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0CX64" } ] } ] }, { "uniprot_ac": "P10081", "gene_name": "TIF1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P10081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10081" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P10081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10081" } ] } ] }, { "uniprot_ac": "P10266", "gene_name": "ERVK-10", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P10266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10266" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P10266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10266" } ] }, { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P10266", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10266" } ] } ] }, { "uniprot_ac": "P10400", "gene_name": "Pol", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P10400", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10400" } ] } ] }, { "uniprot_ac": "P10630", "gene_name": "Eif4a2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P10630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10630" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P10630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10630" } ] } ] }, { "uniprot_ac": "P10981", "gene_name": "Act87E", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10981" } ] } ] }, { "uniprot_ac": "P10987", "gene_name": "Act5C", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P10987", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10987" } ] } ] }, { "uniprot_ac": "P11021", "gene_name": "HSPA5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11021" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11021", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11021" } ] } ] }, { "uniprot_ac": "P11142", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] } ] }, { "uniprot_ac": "P11369", "gene_name": "Pol", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P11369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11369" } ] }, { "ec_number": "3.1.21.-", "activity": "", "evidence": [ { "id": "P11369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11369" } ] } ] }, { "uniprot_ac": "P11484", "gene_name": "SSB1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11484" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11484" } ] } ] }, { "uniprot_ac": "P12954", "gene_name": "SRS2", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "P12954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12954" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "P12954", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12954" } ] } ] }, { "uniprot_ac": "P13382", "gene_name": "POL1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P13382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13382" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P13382", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13382" } ] } ] }, { "uniprot_ac": "P14284", "gene_name": "REV3", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P14284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14284" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P14284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14284" } ] } ] }, { "uniprot_ac": "P15424", "gene_name": "MSS116", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P15424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15424" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P15424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15424" } ] } ] }, { "uniprot_ac": "P15436", "gene_name": "POL3", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P15436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15436" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P15436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15436" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P15436", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15436" } ] } ] }, { "uniprot_ac": "P15801", "gene_name": "MIP1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P15801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15801" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P15801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15801" } ] } ] }, { "uniprot_ac": "P15938", "gene_name": "PRP16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P15938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15938" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P15938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15938" } ] } ] }, { "uniprot_ac": "P16381", "gene_name": "D1Pas1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P16381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16381" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P16381", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16381" } ] } ] }, { "uniprot_ac": "P16474", "gene_name": "KAR2", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P16474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16474" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P16474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16474" } ] } ] }, { "uniprot_ac": "P16521", "gene_name": "YEF3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P16521", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16521" } ] } ] }, { "uniprot_ac": "P17119", "gene_name": "KAR3", "activity": [ { "ec_number": "5.6.1.4", "activity": "ATP + H2O + a kinesin associated with a microtubule at position (n) = ADP + phosphate + a kinesin associated with a microtubule at position (n-1, toward the minus end).", "evidence": [ { "id": "P17119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17119" } ] }, { "ec_number": "5.6.1.4", "activity": "", "evidence": [ { "id": "P17119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17119" } ] } ] }, { "uniprot_ac": "P17844", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] } ] }, { "uniprot_ac": "P18074", "gene_name": "ERCC2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P18074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18074" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P18074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18074" } ] } ] }, { "uniprot_ac": "P19109", "gene_name": "Rm62", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P19109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19109" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P19109", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19109" } ] } ] }, { "uniprot_ac": "P19447", "gene_name": "ERCC3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P19447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19447" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P19447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19447" } ] } ] }, { "uniprot_ac": "P20029", "gene_name": "Hspa5", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20029" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P20029", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20029" } ] } ] }, { "uniprot_ac": "P20095", "gene_name": "PRP2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20095", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20095" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20095", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20095" } ] } ] }, { "uniprot_ac": "P20447", "gene_name": "DBP3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20447" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20447" } ] } ] }, { "uniprot_ac": "P20448", "gene_name": "HCA4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20448" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20448" } ] } ] }, { "uniprot_ac": "P20449", "gene_name": "DBP5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P20449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20449" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P20449", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20449" } ] } ] }, { "uniprot_ac": "P20480", "gene_name": "ncd", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P20480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20480" } ] } ] }, { "uniprot_ac": "P21372", "gene_name": "PRP5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P21372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21372" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P21372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21372" } ] } ] }, { "uniprot_ac": "P21951", "gene_name": "POL2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P21951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21951" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P21951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21951" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P21951", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21951" } ] } ] }, { "uniprot_ac": "P22516", "gene_name": "CHL1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P22516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22516" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P22516", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22516" } ] } ] }, { "uniprot_ac": "P23128", "gene_name": "me31B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23128" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23128" } ] } ] }, { "uniprot_ac": "P23249", "gene_name": "Mov10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23249" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23249", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23249" } ] } ] }, { "uniprot_ac": "P23394", "gene_name": "PRP28", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P23394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23394" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P23394", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23394" } ] } ] }, { "uniprot_ac": "P24004", "gene_name": "PEX1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P24004", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24004" } ] } ] }, { "uniprot_ac": "P24279", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24279" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P24279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24279" } ] } ] }, { "uniprot_ac": "P24384", "gene_name": "PRP22", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24384" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24384", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24384" } ] } ] }, { "uniprot_ac": "P24783", "gene_name": "DBP2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24783" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24783" } ] } ] }, { "uniprot_ac": "P24784", "gene_name": "DBP1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24784" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24784" } ] } ] }, { "uniprot_ac": "P24785", "gene_name": "mle", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P24785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24785" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P24785", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24785" } ] } ] }, { "uniprot_ac": "P25205", "gene_name": "MCM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25205" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25205" } ] } ] }, { "uniprot_ac": "P25206", "gene_name": "Mcm3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25206" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P25206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25206" } ] } ] }, { "uniprot_ac": "P25384", "gene_name": "TY2B-C", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P25384", "database": "UniProtKB", "url": 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"activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P25808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25808" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P25808", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25808" } ] } ] }, { "uniprot_ac": "P26019", "gene_name": "PolA1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P26019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26019" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P26019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26019" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P26019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26019" } ] } ] }, { "uniprot_ac": "P26196", "gene_name": "DDX6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P26196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26196" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P26196", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26196" } ] } ] }, { "uniprot_ac": "P26802", "gene_name": "Dbp73D", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P26802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26802" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P26802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26802" } ] } ] }, { "uniprot_ac": "P28340", "gene_name": "POLD1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P28340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28340" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P28340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28340" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P28340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28340" } ] } ] }, { "uniprot_ac": "P28738", "gene_name": "Kif5c", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P28738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28738" } ] } ] }, { "uniprot_ac": "P29469", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P29469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29469" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P29469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29469" } ] } ] }, { 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"gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30665", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30665" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P30665", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30665" } ] } ] }, { "uniprot_ac": "P30771", "gene_name": "NAM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P30771", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30771" } ] } ] }, { "uniprot_ac": "P31380", "gene_name": "FUN30", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P31380", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31380" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P31380", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31380" } ] } ] }, { "uniprot_ac": "P32580", "gene_name": "SUV3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32580" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P32580", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32580" } ] } ] }, { "uniprot_ac": "P32597", "gene_name": "STH1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32597" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P32597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32597" } ] } ] }, { "uniprot_ac": "P32639", "gene_name": "BRR2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32639" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P32639", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32639" } ] } ] }, { "uniprot_ac": "P32644", "gene_name": "ECM32", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32644" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P32644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32644" } ] } ] }, { "uniprot_ac": "P32794", "gene_name": "AFG2", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32794" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P32794", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32794" } ] } ] }, { "uniprot_ac": "P32807", "gene_name": "YKU70", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32807" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P32807", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32807" } ] } ] }, { "uniprot_ac": "P32863", "gene_name": "RAD54", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32863" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P32863", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32863" } ] } ] }, { "uniprot_ac": "P32892", "gene_name": "DRS1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P32892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32892" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P32892", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32892" } ] } ] }, { "uniprot_ac": "P33609", "gene_name": "Pola1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P33609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33609" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P33609", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33609" } ] } ] }, { "uniprot_ac": "P33760", "gene_name": "PEX6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P33760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33760" } ] } ] }, { "uniprot_ac": "P33991", "gene_name": "MCM4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P33991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33991" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P33991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33991" } ] } ] }, { "uniprot_ac": "P33992", "gene_name": "MCM5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P33992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33992" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P33992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33992" } ] } ] }, { "uniprot_ac": "P33993", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P33993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33993" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P33993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33993" } ] } ] }, { "uniprot_ac": "P34243", "gene_name": "HCS1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P34243", "database": "UniProtKB", "url": 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"P36120", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36120" } ] } ] }, { "uniprot_ac": "P38086", "gene_name": "RDH54", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38086" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P38086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38086" } ] } ] }, { "uniprot_ac": "P38112", "gene_name": "MAK5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38112" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P38112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38112" } ] } ] }, { "uniprot_ac": "P38132", "gene_name": "MCM7", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38132" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P38132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38132" } ] } ] }, { "uniprot_ac": "P38712", "gene_name": "RRP3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38712" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P38712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38712" } ] } ] }, { "uniprot_ac": "P38719", "gene_name": "DBP8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38719" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P38719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38719" } ] } ] }, { "uniprot_ac": "P38766", "gene_name": "RRM3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38766" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P38766", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38766" } ] } ] }, { "uniprot_ac": "P38859", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P38859", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38859" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38859", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38859" } ] } ] }, { "uniprot_ac": "P38919", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38919" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P38919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38919" } ] } ] }, { "uniprot_ac": "P38935", "gene_name": "IGHMBP2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38935" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P38935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38935" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38935" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P38935", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38935" } ] } ] }, { "uniprot_ac": "P39517", "gene_name": "DHH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P39517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39517" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P39517", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39517" } ] } ] }, { "uniprot_ac": "P39985", "gene_name": "POL5", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P39985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39985" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P39985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39985" } ] } ] }, { "uniprot_ac": "P40024", "gene_name": "ARB1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P40024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40024" } ] } ] }, { "uniprot_ac": "P40105", "gene_name": "YRF1-2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40105" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P40105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40105" } ] } ] }, { "uniprot_ac": "P40150", "gene_name": "SSB2", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40150" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P40150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40150" } ] } ] }, { "uniprot_ac": "P40201", "gene_name": "Chd1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40201" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P40201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40201" } ] } ] }, { "uniprot_ac": "P40352", "gene_name": "RAD26", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40352" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P40352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40352" } ] } ] }, { "uniprot_ac": "P40434", "gene_name": "", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40434" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P40434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40434" } ] } ] }, { "uniprot_ac": "P40562", "gene_name": "MPH1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40562" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P40562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40562" } ] } ] }, { "uniprot_ac": "P40694", "gene_name": "Ighmbp2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40694" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40694" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P40694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40694" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P40694", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40694" } ] } ] }, { "uniprot_ac": "P40889", "gene_name": "", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P40889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40889" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P40889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40889" } ] } ] }, { "uniprot_ac": "P42285", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P42285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42285" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P42285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42285" } ] } ] }, { "uniprot_ac": "P43538", "gene_name": "", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P43538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43538" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P43538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43538" } ] } ] }, { "uniprot_ac": "P45818", "gene_name": "ROK1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P45818", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45818" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P45818", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45818" } ] } ] }, { "uniprot_ac": "P46063", "gene_name": "RECQL", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46063" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P46063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46063" } ] } ] }, { "uniprot_ac": "P46100", "gene_name": "ATRX", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46100" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P46100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46100" } ] } ] }, { "uniprot_ac": "P46459", "gene_name": "NSF", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46459" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46459" } ] } ] }, { "uniprot_ac": "P46460", "gene_name": "Nsf", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46460" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46460", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46460" } ] } ] }, { "uniprot_ac": "P46461", "gene_name": "comt", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46461" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46461" } ] } ] }, { "uniprot_ac": "P46462", "gene_name": "Vcp", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46462" } ] } ] }, { "uniprot_ac": "P46467", "gene_name": "Vps4b", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P46467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46467" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P46467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46467" } ] } ] }, { "uniprot_ac": "P46957", "gene_name": "POL31", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P46957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46957" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P46957", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46957" } ] } ] }, { "uniprot_ac": "P47024", "gene_name": "TY4B-J", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P47024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47024" } ] } ] }, { "uniprot_ac": "P47047", "gene_name": "MTR4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P47047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47047" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P47047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47047" } ] } ] }, { "uniprot_ac": "P47098", "gene_name": "TY1B-JR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47098" } ] } ] }, { "uniprot_ac": "P47100", "gene_name": "TY1B-JR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P47100", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47100" } ] } ] }, { "uniprot_ac": "P49135", "gene_name": "Ercc3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P49135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49135" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P49135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49135" } ] } ] }, { "uniprot_ac": "P49717", "gene_name": "Mcm4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P49717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49717" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P49717", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49717" } ] } ] }, { "uniprot_ac": "P49718", "gene_name": "Mcm5", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P49718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49718" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P49718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49718" } ] } ] }, { "uniprot_ac": "P49735", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P49735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49735" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P49735", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49735" } ] } ] }, { "uniprot_ac": "P49736", "gene_name": "MCM2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P49736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49736" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P49736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49736" } ] } ] }, { "uniprot_ac": "P49961", "gene_name": "ENTPD1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.", "evidence": [ { "id": "P49961", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49961" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "P49961", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49961" } ] } ] }, { "uniprot_ac": "P51530", "gene_name": "DNA2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P51530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51530" } ] }, { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P51530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51530" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P51530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51530" } ] } ] }, { "uniprot_ac": "P51979", "gene_name": "HFM1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P51979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51979" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P51979", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51979" } ] } ] }, { "uniprot_ac": "P52431", "gene_name": "Pold1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P52431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52431" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P52431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52431" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P52431", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52431" } ] } ] }, { "uniprot_ac": "P53091", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P53091", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53091" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P53091", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53091" } ] } ] }, { "uniprot_ac": "P53115", "gene_name": "INO80", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P53115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53115" } ] } ] }, { "uniprot_ac": "P53131", "gene_name": "PRP43", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P53131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53131" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P53131", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53131" } ] } ] }, { "uniprot_ac": "P53166", "gene_name": "MRH4", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P53166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53166" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P53166", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53166" } ] } ] }, { "uniprot_ac": "P53327", "gene_name": "SLH1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P53327", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53327" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P53327", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53327" } ] } ] }, { "uniprot_ac": "P53501", "gene_name": "Act57B", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P53501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53501" } ] } ] }, { "uniprot_ac": "P53734", "gene_name": "DBP6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P53734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53734" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P53734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53734" } ] } ] }, { "uniprot_ac": "P53819", "gene_name": "YRF1-6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P53819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53819" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P53819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53819" } ] } ] }, { "uniprot_ac": "P53978", "gene_name": "HEF3", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P53978", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53978" } ] } ] }, { "uniprot_ac": "P54098", "gene_name": "POLG", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P54098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54098" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P54098", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54098" } ] } ] }, { "uniprot_ac": "P54099", "gene_name": "Polg", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P54099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54099" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P54099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54099" } ] } ] }, { "uniprot_ac": "P54132", "gene_name": "BLM", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P54132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54132" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P54132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54132" } ] } ] }, { "uniprot_ac": "P54278", "gene_name": "PMS2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P54278", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54278" } ] } ] }, { "uniprot_ac": "P54279", "gene_name": "Pms2", "activity": [ { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "P54279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54279" } ] } ] }, { "uniprot_ac": "P54351", "gene_name": "Nsf2", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P54351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54351" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P54351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54351" } ] } ] }, { "uniprot_ac": "P54358", "gene_name": "PolD1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P54358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54358" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "P54358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54358" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "P54358", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54358" } ] } ] }, { "uniprot_ac": "P54777", "gene_name": "Pex6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P54777", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54777" } ] } ] }, { "uniprot_ac": "P54823", "gene_name": "Ddx6", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P54823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54823" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P54823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54823" } ] } ] }, { "uniprot_ac": "P55072", "gene_name": "VCP", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P55072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55072" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "P55072", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55072" } ] } ] }, { "uniprot_ac": "P55772", "gene_name": "Entpd1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.", "evidence": [ { "id": "P55772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55772" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "P55772", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55772" } ] } ] }, { "uniprot_ac": "P56536", "gene_name": "Kif5c", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P56536", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56536" } ] } ] }, { "uniprot_ac": "P60010", "gene_name": "ACT1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60010", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60010" } ] } ] }, { "uniprot_ac": "P60122", "gene_name": "Ruvbl1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P60122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60122" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P60122", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60122" } ] } ] }, { "uniprot_ac": "P60123", "gene_name": "Ruvbl1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P60123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60123" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P60123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60123" } ] } ] }, { "uniprot_ac": "P60709", "gene_name": "ACTB", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60709" } ] } ] }, { "uniprot_ac": "P60710", "gene_name": "Actb", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60710", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60710" } ] } ] }, { "uniprot_ac": "P60711", "gene_name": "Actb", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P60711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60711" } ] } ] }, { "uniprot_ac": "P60842", "gene_name": "EIF4A1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P60842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60842" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P60842", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60842" } ] } ] }, { "uniprot_ac": "P60843", "gene_name": "Eif4a1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P60843", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60843" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P60843", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60843" } ] } ] }, { "uniprot_ac": "P61221", "gene_name": "ABCE1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P61221", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61221" } ] } ] }, { "uniprot_ac": "P61222", "gene_name": "Abce1", "activity": [ { "ec_number": "3.6.5.-", "activity": "", "evidence": [ { "id": "P61222", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61222" } ] } ] }, { "uniprot_ac": "P62736", "gene_name": "ACTA2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62736" } ] } ] }, { "uniprot_ac": "P62737", "gene_name": "Acta2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62737", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62737" } ] } ] }, { "uniprot_ac": "P62738", "gene_name": "Acta2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P62738", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62738" } ] } ] }, { "uniprot_ac": "P63017", "gene_name": "Hspa8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P63017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63017" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P63017", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63017" } ] } ] }, { "uniprot_ac": "P63018", "gene_name": "Hspa8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P63018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63018" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P63018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63018" } ] } ] }, { "uniprot_ac": "P63128", "gene_name": "ERVK-9", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] }, { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63128", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63128" } ] } ] }, { "uniprot_ac": "P63132", "gene_name": "HERVK_113", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63132" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63132" } ] } ] }, { "uniprot_ac": "P63133", "gene_name": "ERVK-8", "activity": [ { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63133" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63133" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63133" } ] } ] }, { "uniprot_ac": "P63135", "gene_name": "ERVK-7", "activity": [ { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63135" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63135" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63135", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63135" } ] } ] }, { "uniprot_ac": "P63136", "gene_name": "ERVK-25", "activity": [ { "ec_number": "3.4.23.50", "activity": "Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.", "evidence": [ { "id": "P63136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63136" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "P63136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63136" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "P63136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63136" } ] } ] }, { "uniprot_ac": "P63259", "gene_name": "Actg1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63259", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63259" } ] } ] }, { "uniprot_ac": "P63260", "gene_name": "Actg1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63260" } ] } ] }, { "uniprot_ac": "P63261", "gene_name": "ACTG1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63261", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63261" } ] } ] }, { "uniprot_ac": "P63267", "gene_name": "ACTG2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63267" } ] } ] }, { "uniprot_ac": "P63268", "gene_name": "Actg2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63268" } ] } ] }, { "uniprot_ac": "P63269", "gene_name": "Actg2", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P63269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63269" } ] } ] }, { "uniprot_ac": "P68032", "gene_name": "ACTC1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68032" } ] } ] }, { "uniprot_ac": "P68033", "gene_name": "Actc1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68033" } ] } ] }, { "uniprot_ac": "P68035", "gene_name": "Actc1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68035" } ] } ] }, { "uniprot_ac": "P68133", "gene_name": "ACTA1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68133", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68133" } ] } ] }, { "uniprot_ac": "P68134", "gene_name": "Acta1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68134" } ] } ] }, { "uniprot_ac": "P68136", "gene_name": "Acta1", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P68136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68136" } ] } ] }, { "uniprot_ac": "P70270", "gene_name": "Rad54l", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P70270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70270" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P70270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70270" } ] } ] }, { "uniprot_ac": "P70486", "gene_name": "Atrx", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P70486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70486" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P70486", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70486" } ] } ] }, { "uniprot_ac": "P82995", "gene_name": "Hsp90aa1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P82995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82995" } ] } ] }, { "uniprot_ac": "P83967", "gene_name": "Act88F", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "P83967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83967" } ] } ] }, { "uniprot_ac": "P90529", "gene_name": "ifdA", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P90529", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P90529" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P90529", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P90529" } ] } ] }, { "uniprot_ac": "P97310", "gene_name": "Mcm2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P97310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97310" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P97310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97310" } ] } ] }, { "uniprot_ac": "P97311", "gene_name": "Mcm6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P97311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97311" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P97311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97311" } ] } ] }, { "uniprot_ac": "P97687", "gene_name": "Entpd1", "activity": [ { "ec_number": "3.6.1.5", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + 2 H2O = a 2'-deoxyribonucleoside 5'-phosphate + 2 H(+) + 2 phosphate.", "evidence": [ { "id": "P97687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97687" } ] }, { "ec_number": "3.6.1.5", "activity": "", "evidence": [ { "id": "P97687", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97687" } ] } ] }, { "uniprot_ac": "P97855", "gene_name": "G3bp1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P97855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97855" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P97855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97855" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "P97855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97855" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P97855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97855" } ] } ] }, { "uniprot_ac": "Q00578", "gene_name": "SSL2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q00578", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00578" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q00578", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00578" } ] } ] }, { "uniprot_ac": "Q01853", "gene_name": "Vcp", "activity": [ { "ec_number": "3.6.4.6", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q01853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01853" } ] }, { "ec_number": "3.6.4.6", "activity": "", "evidence": [ { "id": "Q01853", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01853" } ] } ] }, { "uniprot_ac": "Q02748", "gene_name": "eIF4A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q02748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02748" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q02748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02748" } ] } ] }, { "uniprot_ac": "Q02870", "gene_name": "hay", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q02870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02870" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q02870", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02870" } ] } ] }, { "uniprot_ac": "Q03099", "gene_name": "", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q03099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03099" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q03099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03099" } ] } ] }, { "uniprot_ac": "Q03434", "gene_name": "TY1B-ML2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03434" } ] } ] }, { "uniprot_ac": "Q03468", "gene_name": "ERCC6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q03468", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03468" } ] } ] }, { "uniprot_ac": "Q03494", "gene_name": "TY2B-DR2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03494" } ] } ] }, { "uniprot_ac": "Q03532", "gene_name": "HAS1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q03532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03532" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q03532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03532" } ] } ] }, { "uniprot_ac": "Q03612", "gene_name": "TY1B-ER1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03612" } ] } ] }, { "uniprot_ac": "Q03619", "gene_name": "TY1B-ER2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03619" } ] } ] }, { "uniprot_ac": "Q03855", "gene_name": "TY1B-DR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q03855", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03855" } ] } ] }, { "uniprot_ac": "Q03940", "gene_name": "RVB1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q03940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03940" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q03940", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03940" } ] } ] }, { "uniprot_ac": "Q04049", "gene_name": "RAD30", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04049" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q04049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04049" } ] } ] }, { "uniprot_ac": "Q04214", "gene_name": "TY1B-MR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04214", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04214" } ] } ] }, { "uniprot_ac": "Q04217", "gene_name": "ECM16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q04217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04217" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q04217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04217" } ] } ] }, { "uniprot_ac": "Q04437", "gene_name": "YKU80", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q04437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04437" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q04437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04437" } ] } ] }, { "uniprot_ac": "Q04670", "gene_name": "TY1B-MR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04670", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04670" } ] } ] }, { "uniprot_ac": "Q04692", "gene_name": "Smarcad1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q04692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04692" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q04692", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04692" } ] } ] }, { "uniprot_ac": "Q04711", "gene_name": "TY1B-ML1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q04711", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04711" } ] } ] }, { "uniprot_ac": "Q05471", "gene_name": "SWR1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q05471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05471" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05471" } ] } ] }, { "uniprot_ac": "Q05549", "gene_name": "HRQ1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q05549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05549" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q05549", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05549" } ] } ] }, { "uniprot_ac": "Q05931", "gene_name": "SSQ1", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q05931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05931" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "Q05931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05931" } ] } ] }, { "uniprot_ac": "Q06163", "gene_name": "EST2", "activity": [ { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q06163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06163" } ] }, { "ec_number": "2.7.7.49", "activity": "", "evidence": [ { "id": "Q06163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06163" } ] } ] }, { "uniprot_ac": "Q06218", "gene_name": "DBP9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q06218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06218" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q06218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06218" } ] } ] }, { "uniprot_ac": "Q06698", "gene_name": "", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q06698", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06698" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q06698", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06698" } ] } ] }, { "uniprot_ac": "Q07478", "gene_name": "SUB2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q07478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07478" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q07478", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07478" } ] } ] }, { "uniprot_ac": "Q07791", "gene_name": "TY2B-DR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07791", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07791" } ] } ] }, { "uniprot_ac": "Q07793", "gene_name": "TY1B-DR4", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07793" } ] } ] }, { "uniprot_ac": "Q07864", "gene_name": "POLE", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q07864", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07864" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q07864", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07864" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q07864", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07864" } ] } ] }, { "uniprot_ac": "Q07886", "gene_name": "Dbp45A", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q07886", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07886" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q07886", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07886" } ] } ] }, { "uniprot_ac": "Q07888", "gene_name": "", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q07888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07888" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q07888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07888" } ] } ] }, { "uniprot_ac": "Q08211", "gene_name": "DHX9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q08211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08211" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q08211", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08211" } ] } ] }, { "uniprot_ac": "Q08995", "gene_name": "", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q08995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08995" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q08995", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08995" } ] } ] }, { "uniprot_ac": "Q09XV5", "gene_name": "Chd8", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q09XV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09XV5" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q09XV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09XV5" } ] } ] }, { "uniprot_ac": "Q0VGM9", "gene_name": "Rtel1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q0VGM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VGM9" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q0VGM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VGM9" } ] } ] }, { "uniprot_ac": "Q0VGT4", "gene_name": "Zgrf1", "activity": [ { "ec_number": "5.6.2.3", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.", "evidence": [ { "id": "Q0VGT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VGT4" } ] }, { "ec_number": "5.6.2.3", "activity": "", "evidence": [ { "id": "Q0VGT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q0VGT4" } ] } ] }, { "uniprot_ac": "Q12039", "gene_name": "HMI1", "activity": [ { "ec_number": "5.6.2.4", "activity": "Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.", "evidence": [ { "id": "Q12039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12039" } ] }, { "ec_number": "5.6.2.4", "activity": "", "evidence": [ { "id": "Q12039", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12039" } ] } ] }, { "uniprot_ac": "Q12088", "gene_name": "TY1B-LR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12088" } ] } ] }, { "uniprot_ac": "Q12099", "gene_name": "FAL1", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q12099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12099" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q12099", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12099" } ] } ] }, { "uniprot_ac": "Q12112", "gene_name": "TY1B-NL1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12112" } ] } ] }, { "uniprot_ac": "Q12113", "gene_name": "TY2B-OR1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12113", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12113" } ] } ] }, { "uniprot_ac": "Q12141", "gene_name": "TY1B-GR1", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12141" } ] } ] }, { "uniprot_ac": "Q12193", "gene_name": "TY1B-BR", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12193", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12193" } ] } ] }, { "uniprot_ac": "Q12269", "gene_name": "TY1B-GR2", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12269", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12269" } ] } ] }, { "uniprot_ac": "Q12273", "gene_name": "TY1B-OL", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12273", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12273" } ] } ] }, { "uniprot_ac": "Q12316", "gene_name": "TY1B-GR3", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12316", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12316" } ] } ] }, { "uniprot_ac": "Q12389", "gene_name": "DBP10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q12389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12389" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q12389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12389" } ] } ] }, { "uniprot_ac": "Q12414", "gene_name": "TY1B-PL", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12414" } ] } ] }, { "uniprot_ac": "Q12464", "gene_name": "RVB2", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q12464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12464" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q12464", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12464" } ] } ] }, { "uniprot_ac": "Q12472", "gene_name": "TY2B-DR1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12472" } ] } ] }, { "uniprot_ac": "Q12490", "gene_name": "TY1B-BL", "activity": [ { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] }, { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12490" } ] } ] }, { "uniprot_ac": "Q12491", "gene_name": "TY2B-B", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12491" } ] } ] }, { "uniprot_ac": "Q12501", "gene_name": "TY2B-OR2", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] }, { "ec_number": "3.1.26.4", "activity": "Endonucleolytic cleavage to 5'-phosphomonoester.", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] }, { "ec_number": "2.7.7.49", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] }, { "ec_number": "3.4.23.-", "activity": "", "evidence": [ { "id": "Q12501", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12501" } ] } ] }, { "uniprot_ac": "Q12697", "gene_name": "YPK9", "activity": [ { "ec_number": "7.2.2.-", "activity": "", "evidence": [ { "id": "Q12697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12697" } ] } ] }, { "uniprot_ac": "Q12873", "gene_name": "CHD3", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q12873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12873" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q12873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12873" } ] } ] }, { "uniprot_ac": "Q13206", "gene_name": "DDX10", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q13206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13206" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q13206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13206" } ] } ] }, { "uniprot_ac": "Q13283", "gene_name": "G3BP1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q13283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13283" } ] }, { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q13283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13283" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q13283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13283" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q13283", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13283" } ] } ] }, { "uniprot_ac": "Q13608", "gene_name": "PEX6", "activity": [ { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q13608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13608" } ] } ] }, { "uniprot_ac": "Q13838", "gene_name": "DDX39B", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q13838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13838" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q13838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13838" } ] } ] }, { "uniprot_ac": "Q14147", "gene_name": "DHX34", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q14147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14147" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q14147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14147" } ] } ] }, { "uniprot_ac": "Q14191", "gene_name": "WRN", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q14191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14191" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q14191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14191" } ] } ] }, { "uniprot_ac": "Q14240", "gene_name": "EIF4A2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q14240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14240" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q14240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14240" } ] } ] }, { "uniprot_ac": "Q14562", "gene_name": "DHX8", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q14562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14562" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q14562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14562" } ] } ] }, { "uniprot_ac": "Q14566", "gene_name": "MCM6", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q14566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14566" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q14566", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14566" } ] } ] }, { "uniprot_ac": "Q14839", "gene_name": "CHD4", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q14839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14839" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q14839", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14839" } ] } ] }, { "uniprot_ac": "Q14BI7", "gene_name": "Tdrd9", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q14BI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14BI7" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q14BI7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14BI7" } ] } ] }, { "uniprot_ac": "Q15477", "gene_name": "SKIC2", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q15477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15477" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q15477", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15477" } ] } ] }, { "uniprot_ac": "Q1HG60", "gene_name": "Pif1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q1HG60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1HG60" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q1HG60", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1HG60" } ] } ] }, { "uniprot_ac": "Q1ZXF2", "gene_name": "polB", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q1ZXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXF2" } ] }, { "ec_number": "2.7.7.7", "activity": "", "evidence": [ { "id": "Q1ZXF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q1ZXF2" } ] } ] }, { "uniprot_ac": "Q23976", "gene_name": "Irbp", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q23976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23976" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q23976", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23976" } ] } ] }, { "uniprot_ac": "Q26454", "gene_name": "dpa", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q26454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q26454" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q26454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q26454" } ] } ] }, { "uniprot_ac": "Q27268", "gene_name": "Hel25E", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q27268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27268" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q27268", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27268" } ] } ] }, { "uniprot_ac": "Q27607", "gene_name": "PolG1", "activity": [ { "ec_number": "2.7.7.7", "activity": "a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1).", "evidence": [ { "id": "Q27607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27607" } ] }, { "ec_number": "3.1.11.-", "activity": "", "evidence": [ { "id": "Q27607", "database": 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[ { "id": "Q9VQN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VQN8" } ] } ] }, { "uniprot_ac": "Q9VQR3", "gene_name": "Pif1", "activity": [ { "ec_number": "3.6.4.12", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q9VQR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VQR3" } ] }, { "ec_number": "3.6.4.12", "activity": "", "evidence": [ { "id": "Q9VQR3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VQR3" } ] } ] }, { "uniprot_ac": "Q9VRI0", "gene_name": "Ddx56", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "Q9VRI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VRI0" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "Q9VRI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VRI0" } ] } ] }, { "uniprot_ac": "Q9VSE2", "gene_name": "mus301", "activity": [ { 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