{ "uniprot_canonical_ac": "O75414-1", "uniprot_ac": "O75414", "uniprot_id": "NDK6_HUMAN", "mass": { "chemical_mass": 21142.0, "monoisotopic_mass": 21142.0 }, "refseq": { "ac": "NP_001295355", "name": "nucleoside diphosphate kinase 6 isoform 2", "summary": "Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355" }, "gene_names": [ { "name": "NME6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75414", "id": "O75414" }, { "name": "IPIA-ALPHA; NDK 6; NM23-H6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355", "id": "NP_001295355" }, { "name": "NME6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355", "id": "NP_001295355" }, { "name": "hCG_1779448", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75414", "id": "O75414" } ], "protein_names": [ { "name": "Nucleoside diphosphate kinase 6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75414" }, { "name": "2.7.4.6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75414" }, { "name": "IPIA-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75414" }, { "name": "Inhibitor of p53-induced apoptosis-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75414" }, { "name": "NDK 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75414" }, { "name": "NDP kinase 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75414" }, { "name": "nm23-H6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75414" }, { "name": "nucleoside diphosphate kinase 6 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355", "id": "NP_001295355" }, { "name": "nucleoside diphosphate kinase 6; inhibitor of p53-induced apoptosis-alpha; NDP kinase 6; non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355", "id": "NP_001295355" } ], "function": [ { "annotation": "It was suggested that rs1076394 served as an expression Quantitative Trait Loci (eQTL) for gene CCDC12 and NME6, while NME6's expression was obviously higher in colorectal cancer tissues. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001295355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355" }, { "database": "PubMed", "id": "27120998", "url": "https://glygen.org/publication/PubMed/27120998" } ] }, { "annotation": "Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Inhibitor of p53-induced apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414#function" } ] }, { "annotation": "Nucleoside diphosphate (NDP) kinases (EC 2.7.4.6), such as NME6, are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates (Mehus et al., 1999 [PubMed 10453732]).[supplied by OMIM, Jul 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001295355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001295355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355" }, { "database": "PubMed", "id": "20877624", "url": "https://glygen.org/publication/PubMed/20877624" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "76.81", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "66.95", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "72.02", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "85.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "87.85", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "79.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "83.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "76.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "85.43", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "82.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000172113", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000172113" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75414", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75414" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"https://www.ensembl.org/id/ENST00000421967.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000416658.1", "url": "https://www.ensembl.org/id/ENSP00000416658.1" } ] } }, { "isoform_ac": "A0A2R8Y547-1", "url": "", "sequence": { "sequence": "MGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA", "length": 88, "header": "tr|A0A2R8Y547-1|NDK6_HUMAN Computationally mapped isoform of Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=1 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48295174, "end_pos": 48294640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000444069.5", "url": "https://www.ensembl.org/id/ENST00000444069.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000493725.1", "url": "https://www.ensembl.org/id/ENSP00000493725.1" } ] } }, { "isoform_ac": "A0A2R8Y7V2-1", "url": "", "sequence": { "sequence": "MTQNLGGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA", "length": 114, "header": "tr|A0A2R8Y7V2-1|A0A2R8Y7V2_HUMAN Computationally mapped isoform of Nucleoside diphosphate kinase OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=1 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48301312, "end_pos": 48294640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000643011.1", "url": "https://www.ensembl.org/id/ENST00000643011.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496560.1", "url": "https://www.ensembl.org/id/ENSP00000496560.1" } ] } }, { "isoform_ac": "C9J1J2-1", "url": "", "sequence": { "sequence": "MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVA", "length": 111, "header": "tr|C9J1J2-1|NDK6_HUMAN Computationally mapped isoform of Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=1 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48298516, "end_pos": 48295136, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000456495.5", "url": "https://www.ensembl.org/id/ENST00000456495.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000392715.1", "url": "https://www.ensembl.org/id/ENSP00000392715.1" } ] } }, { "isoform_ac": "C9J867-1", "url": "", "sequence": { "sequence": "MRLERSEMASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKE", "length": 61, "header": "tr|C9J867-1|C9J867_HUMAN Computationally mapped isoform of NME/NM23 nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=1 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48300290, "end_pos": 48296758, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000447724.1", "url": "https://www.ensembl.org/id/ENST00000447724.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000405755.1", "url": "https://www.ensembl.org/id/ENSP00000405755.1" } ] } }, { "isoform_ac": "C9J9V6-1", "url": "", "sequence": { "sequence": "MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGV", "length": 174, "header": "tr|C9J9V6-1|NDK6_HUMAN Computationally mapped isoform of Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=1 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48298516, "end_pos": 48294676, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000425930.5", "url": "https://www.ensembl.org/id/ENST00000425930.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000411116.1", "url": "https://www.ensembl.org/id/ENSP00000411116.1" } ] } }, { "isoform_ac": "C9JQB1-1", "url": "", "sequence": { "sequence": "MRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA", "length": 141, "header": "tr|C9JQB1-1|NDK6_HUMAN Computationally mapped isoform of Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=1 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48296784, "end_pos": 48294640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000447314.5", "url": "https://www.ensembl.org/id/ENST00000447314.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000414842.1", "url": "https://www.ensembl.org/id/ENSP00000414842.1" } ] } }, { "isoform_ac": "F2Z2J2-1", "url": "", "sequence": { "sequence": "MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGKEVEVQKVALGTRMKVS", "length": 82, "header": "tr|F2Z2J2-1|F2Z2J2_HUMAN Computationally mapped isoform of NME/NM23 nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=1 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48298516, "end_pos": 48296184, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000418431.5", "url": "https://www.ensembl.org/id/ENST00000418431.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000394128.1", "url": "https://www.ensembl.org/id/ENSP00000394128.1" } ] } }, { "isoform_ac": "O75414-1", "url": "", "sequence": { "sequence": "MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA", "length": 186, "header": "sp|O75414-1|NDK6_HUMAN Isoform 1 of Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48298516, "end_pos": 48294640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452211.5", "url": "https://www.ensembl.org/id/ENST00000452211.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000392352.1", "url": "https://www.ensembl.org/id/ENSP00000392352.1" } ] } }, { "isoform_ac": "O75414-2", "url": "", "sequence": { "sequence": "MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA", "length": 119, "header": "sp|O75414-2|NDK6_HUMAN Isoform 2 of Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48298516, "end_pos": 48294640, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000415644.5", "url": "https://www.ensembl.org/id/ENST00000415644.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000394232.1", "url": "https://www.ensembl.org/id/ENSP00000394232.1" } ] } }, { "isoform_ac": "O75414-3", "url": "", "sequence": { "sequence": "MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEAGQSEPTSLPTRMPSSSGGRSWDPPECSEHAMWPQILSVGVSASLTPATPPMVRTLWFQPAERLQPSSLTSVNSAGMRRKSPSCAVALCAIAQREVSTM", "length": 163, "header": "sp|O75414-3|NDK6_HUMAN Isoform 3 of Nucleoside diphosphate kinase 6 OS=Homo sapiens OX=9606 GN=NME6 PE=1 SV=3 CANONICAL=O75414-1" }, "locus": { "chromosome": "3", "start_pos": 48298516, "end_pos": 48294669, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000435684.5", "url": "https://www.ensembl.org/id/ENST00000435684.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000393261.1", "url": "https://www.ensembl.org/id/ENSP00000393261.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O75414", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75414" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3.", "journal": "Hum. Genet.", "date": "1999", "authors": "Mehus JG, Deloukas P, Lambeth DO", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "reference": [ { "type": "PubMed", "id": "10453732", "url": "https://glygen.org/publication/PubMed/10453732" } ] }, { "title": "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.", "journal": "PloS one", "date": "2010", "authors": "Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ", "evidence": [ { "database": "RefSeq", "id": "NP_001295355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355" } ], "reference": [ { "type": "PubMed", "id": "20877624", "url": "https://glygen.org/publication/PubMed/20877624" } ] }, { "title": "Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population.", "journal": "Scientific reports", "date": "2016", "authors": "Ke J, Lou J, Zhong R, Chen X, Li J, Liu C, Gong Y, Yang Y, Zhu Y, Zhang Y, Chang J, Gong J", "evidence": [ { "database": "RefSeq", "id": "NP_001295355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295355" } ], "reference": [ { "type": "PubMed", "id": "27120998", "url": "https://glygen.org/publication/PubMed/27120998" } ] }, { "title": "Synthesis of a Highly Azide-Reactive and Thermosensitive Biofunctional Reagent for Efficient Enrichment and Large-Scale Identification of O-GlcNAc Proteins by Mass Spectrometry.", "journal": "Analytical chemistry", "date": "2017", "authors": "Zhang W, Liu T, Dong H, Bai H, Tian F, Shi Z, Chen M, Wang J, Qin W, Qian X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75414", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75414" } ], "reference": [ { "type": "PubMed", "id": "28510447", "url": "https://glygen.org/publication/PubMed/28510447" } ] } ], "pathway": [ { "id": "hsa:10201", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10201", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O88425-1", "protein_name": "Nucleoside diphosphate kinase 6", "gene_name": "Nme6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTSILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVHYSPEEGIHCAAETGGHKQPNKT", "length": 189 }, "evidence": [ { "id": "45916605", "url": "http://www.informatics.jax.org/homology/45916605", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "O88426-1", "protein_name": "Nucleoside diphosphate kinase 6", "gene_name": "Nme6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "QLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWKPEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQLWRTLMGPTRVFRARHIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVHYSPEEGIHCAAETGGPKPA", "length": 175 }, "evidence": [ { "id": "45916605", "url": "http://www.informatics.jax.org/homology/45916605", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "nucleoside diphosphate kinase activity", "id": "GO:0004550", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004550", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "phosphorylation", "id": "GO:0016310", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "GTP biosynthetic process", "id": "GO:0006183", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006183", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "UTP biosynthetic process", "id": "GO:0006228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006228", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "CTP biosynthetic process", "id": "GO:0006241", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006241", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "negative regulation of cell growth", "id": "GO:0030308", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030308", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" }, { "name": "negative regulation of mitotic nuclear division", "id": "GO:0045839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045839", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "O75414", "url": "https://www.uniprot.org/uniprot/O75414" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 126, "end_pos": 128, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "18113", "name": "", "equation": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q05982-1", "Q9QXL7-1", "O88426-1", "Q68FP8-1", "Q4KM73-1", "P19804-1", "Q9WUS0-1", "P39069-1", "Q9Z2M4-1", "G3V816-1", "A0A8I6A4T4-1", "A0A8I6AII3-1", "Q5EBM0-1", "Q5TCS8-4", "P27144-1", "P30085-1", "Q9Y6K8-1", "P00568-1", "Q96MA6-1", "Q96M32-1", "Q13232-1", "Q9Y5B8-1", "P15531-1", "O60361-1", "O00746-1", "P22392-1", "O75414-1", "A0A8I5KW96-1", "Q3U5Q7-1", "Q9WUR9-1", "Q9R0Y5-1", "Q920P5-1", "Q32M07-1", "Q9D2H2-2", "Q9DBP5-1", "P15532-1", "Q9QXL8-1", "Q9WV84-1", "Q9WV85-1", "O88425-1", "Q01768-1", "P36010-1", "Q54CG9-1", "P22887-1", "P34093-1", "P08879-1", "Q9VA43-1" ], "evidence": [ { "id": "18113", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/18113" } ] }, { "id": "44640", "name": "", "equation": "a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q05982-1", "Q9QXL7-1", "O88426-1", "Q68FP8-1", "Q4KM73-1", "P19804-1", "Q9WUS0-1", "Q9Z2M4-1", "G3V816-1", "P39069-1", "A0A8I6A4T4-1", "A0A8I6AII3-1", "Q13232-1", "O00746-1", "P22392-1", "O75414-1", "Q5EBM0-1", "Q5TCS8-4", "P27144-1", "P30085-1", "Q9Y6K8-1", "P00568-1", "Q96MA6-1", "Q96M32-1", "Q9Y5B8-1", "P15531-1", "O60361-1", "A0A8I5KW96-1", "Q9WV84-1", "Q3U5Q7-1", "Q9WUR9-1", "Q9R0Y5-1", "Q920P5-1", "Q32M07-1", "Q9D2H2-2", "Q9DBP5-1", "P15532-1", "Q9QXL8-1", "Q9WV85-1", "O88425-1", "Q01768-1", "P36010-1", "Q54CG9-1", "P22887-1", "P34093-1", "P08879-1", "Q9VY27-1", "Q9VA43-1" ], "evidence": [ { "id": "44640", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/44640" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I5KW96", "gene_name": "AK4P3", "activity": [ { "ec_number": "2.7.4.10", "activity": "a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP.", "evidence": [ { "id": "A0A8I5KW96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5KW96" } ] }, { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "A0A8I5KW96", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5KW96" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "A0A8I5KW96", "database": "UniProtKB", "url": 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"activity": "", "evidence": [ { "id": "O00746", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00746" } ] } ] }, { "uniprot_ac": "O60361", "gene_name": "NME2P1", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "O60361", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60361" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "O60361", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60361" } ] } ] }, { "uniprot_ac": "O75414", "gene_name": "NME6", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "O75414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75414" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "O75414", "database": "UniProtKB", "url": 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"activity": "", "evidence": [ { "id": "P00568", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00568" } ] } ] }, { "uniprot_ac": "P08879", "gene_name": "awd", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "P08879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08879" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P08879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08879" } ] } ] }, { "uniprot_ac": "P15531", "gene_name": "NME1", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "P15531", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15531" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "P15531", "database": "UniProtKB", "url": 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ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "Q05982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05982" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q05982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05982" } ] } ] }, { "uniprot_ac": "Q13232", "gene_name": "NME3", "activity": [ { "ec_number": "2.7.4.6", "activity": "a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP.", "evidence": [ { "id": "Q13232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13232" } ] }, { "ec_number": "2.7.4.6", "activity": "", "evidence": [ { "id": "Q13232", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13232" } ] } ] }, { "uniprot_ac": "Q32M07", "gene_name": "Ak8", "activity": [ { "ec_number": "2.7.4.3", "activity": "AMP + ATP = 2 ADP.", "evidence": [ { "id": "Q32M07", "database": "UniProtKB", "url": 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