{ "uniprot_canonical_ac": "O75387-1", "uniprot_ac": "O75387", "uniprot_id": "LAT3_HUMAN", "mass": { "chemical_mass": 61477.0, "monoisotopic_mass": 61477.0 }, "refseq": { "ac": "NP_001185739", "name": "large neutral amino acids transporter small subunit 3", "summary": "SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739" }, "gene_names": [ { "name": "SLC43A1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75387", "id": "O75387" }, { "name": "LAT3; PB39; POV1; R00504", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739", "id": "NP_001185739" }, { "name": "LAT3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75387", "id": "O75387" }, { "name": "PB39", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75387", "id": "O75387" }, { "name": "POV1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75387", "id": "O75387" }, { "name": "SLC43A1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739", "id": "NP_001185739" } ], "protein_names": [ { "name": "Large neutral amino acids transporter small subunit 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75387" }, { "name": "L-type amino acid transporter 3; prostate cancer overexpressed gene 1 protein; solute carrier family 43 (amino acid system L transporter), member 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739", "id": "NP_001185739" }, { "name": "L-type amino acid transporter 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75387" }, { "name": "Prostate cancer overexpressed gene 1 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75387" }, { "name": "Solute carrier family 43 member 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75387" }, { "name": "large neutral amino acids transporter small subunit 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739", "id": "NP_001185739" } ], "function": [ { "annotation": "LAT3 is a transporter subserving system L2 and should denote a new family of organic solute transporters", "evidence": [ { "database": "RefSeq", "id": "NP_001185739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739" }, { "database": "PubMed", "id": "12930836", "url": "https://glygen.org/publication/PubMed/12930836" } ] }, { "annotation": "SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001185739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739" } ] }, { "annotation": "Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:12930836). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:12930836).", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387#function" }, { "database": "PubMed", "id": "12930836", "url": "https://glygen.org/publication/PubMed/12930836" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1278206480", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1278206480" }, { "id": "rs1278206480", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1278206480" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 212, "end_pos": 212, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NCT->SCT).", "chr_id": "11", "chr_pos": "57496088", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N212", "keywords": [ "ebi", "germline" 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"start_pos": 231, "end_pos": 231, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NYT->NYM).", "chr_id": "11", "chr_pos": "57496031", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T231", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1242428124", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1242428124" }, { "id": "rs1242428124", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1242428124" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 289, "end_pos": 289, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLP->NLS).", "chr_id": "11", "chr_pos": "57493999", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P289", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1338237067", "database": "dbSNP", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has 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"id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O75387", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75387" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O75387", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75387" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O75387", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75387" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O75387", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75387" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O75387", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75387" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75387" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "E9PJ68", "url": "https://www.uniprot.org/uniprot/E9PJ68", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PJ68-1", "url": "https://www.uniprot.org/uniprot/E9PJ68-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PJT8", "url": "https://www.uniprot.org/uniprot/E9PJT8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PJT8-1", "url": "https://www.uniprot.org/uniprot/E9PJT8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PR87", "url": "https://www.uniprot.org/uniprot/E9PR87", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PR87-1", "url": "https://www.uniprot.org/uniprot/E9PR87-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PRF0", "url": "https://www.uniprot.org/uniprot/E9PRF0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PRF0-1", "url": "https://www.uniprot.org/uniprot/E9PRF0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YEH0", "url": "https://www.uniprot.org/uniprot/H0YEH0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YEH0-1", "url": "https://www.uniprot.org/uniprot/H0YEH0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75387-1", "url": "https://www.uniprot.org/uniprot/O75387-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75387-2", "url": "https://www.uniprot.org/uniprot/O75387-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA", "length": 559, "header": "sp|O75387-1|LAT3_HUMAN Isoform 1 of Large neutral amino acids transporter small subunit 3 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "isoforms": [ { "isoform_ac": "E9PJ68-1", "url": "", "sequence": { "sequence": "MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPE", "length": 259, "header": "tr|E9PJ68-1|LAT3_HUMAN Computationally mapped isoform of Large neutral amino acids transporter small subunit 3 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "locus": { "chromosome": "11", "start_pos": 57514111, "end_pos": 57493994, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000533066.5", "url": "https://www.ensembl.org/id/ENST00000533066.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435647.1", "url": "https://www.ensembl.org/id/ENSP00000435647.1" } ] } }, { "isoform_ac": "E9PJT8-1", "url": "", "sequence": { "sequence": "MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVG", "length": 110, "header": "tr|E9PJT8-1|E9PJT8_HUMAN Computationally mapped isoform of Solute carrier family 43 member 1 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "locus": { "chromosome": "11", "start_pos": 57514111, "end_pos": 57501154, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000533263.1", "url": "https://www.ensembl.org/id/ENST00000533263.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000435486.1", "url": "https://www.ensembl.org/id/ENSP00000435486.1" } ] } }, { "isoform_ac": "E9PR87-1", "url": "", "sequence": { "sequence": "MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTEEDQAEWAGPGPQGDR", "length": 171, "header": "tr|E9PR87-1|LAT3_HUMAN Computationally mapped isoform of Large neutral amino acids transporter small subunit 3 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "locus": { "chromosome": "11", "start_pos": 57514111, "end_pos": 57494124, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000530159.5", "url": "https://www.ensembl.org/id/ENST00000530159.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000434312.1", "url": "https://www.ensembl.org/id/ENSP00000434312.1" } ] } }, { "isoform_ac": "E9PRF0-1", "url": "", "sequence": { "sequence": "MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAVPGVMC", "length": 58, "header": "tr|E9PRF0-1|LAT3_HUMAN Computationally mapped isoform of Large neutral amino acids transporter small subunit 3 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "locus": { "chromosome": "11", "start_pos": 57514111, "end_pos": 57501355, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000534105.5", "url": "https://www.ensembl.org/id/ENST00000534105.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000432241.1", "url": "https://www.ensembl.org/id/ENSP00000432241.1" } ] } }, { "isoform_ac": "H0YEH0-1", "url": "", "sequence": { "sequence": "XTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTGRGCYQIHQTTLLQDPKAHQCHQCLHPDQPAACGFWHHLSHQQLTPPVCDLCPAHHCSRFLPLSLWESLCCSVPIQPLWDADRPA", "length": 186, "header": "tr|H0YEH0-1|H0YEH0_HUMAN Computationally mapped isoform of Solute carrier family 43 member 1 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "locus": { "chromosome": "11", "start_pos": 57501319, "end_pos": 57487180, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000525764.5", "url": "https://www.ensembl.org/id/ENST00000525764.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435803.1", "url": "https://www.ensembl.org/id/ENSP00000435803.1" } ] } }, { "isoform_ac": "O75387-1", "url": "", "sequence": { "sequence": "MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA", "length": 559, "header": "sp|O75387-1|LAT3_HUMAN Isoform 1 of Large neutral amino acids transporter small subunit 3 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "locus": { "chromosome": "11", "start_pos": 57514111, "end_pos": 57485099, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000278426.8", "url": "https://www.ensembl.org/id/ENST00000278426.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000278426.3", "url": "https://www.ensembl.org/id/ENSP00000278426.3" } ] } }, { "isoform_ac": "O75387-2", "url": "", "sequence": { "sequence": "MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVRARVGVGGAGATLLGAGVGPCMWCHPSLISARGTSEVSNLQVSKLSAF", "length": 560, "header": "sp|O75387-2|LAT3_HUMAN Isoform 2 of Large neutral amino acids transporter small subunit 3 OS=Homo sapiens OX=9606 GN=SLC43A1 PE=1 SV=1 CANONICAL=O75387-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 212, "start_aa": "Asn", "end_pos": 212, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn212", "evidence": [ { "id": "O75387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75387#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 229, "start_aa": "Asn", "end_pos": 229, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn229", "evidence": [ { "id": "O75387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75387#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 57, "start_aa": "Asn", "end_pos": 57, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn57", "evidence": [ { "id": "O75387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75387#ptm_processing" } ] } ], "phosphorylation": [ { "start_pos": 237, "end_pos": 237, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O75387", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75387" } ], "site_lbl": "Ser237" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O75387", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75387" } ], "site_lbl": "Ser262" }, { "start_pos": 267, "end_pos": 267, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O75387", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75387" }, { "database": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ], "site_lbl": "Ser267" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10391915", "url": "https://glygen.org/publication/PubMed/10391915" } ] }, { "title": "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1.", "journal": "The Journal of membrane biology", "date": "1999", "authors": "Kamath SG, Furesz TC, Way BA, Smith CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10485994", "url": "https://glygen.org/publication/PubMed/10485994" } ] }, { "title": "Neutral amino acid transporter ASCT2 displays substrate-induced Na+ exchange and a substrate-gated anion conductance.", "journal": "The Biochemical journal", "date": "2000", "authors": "Broer A, Wagner C, Lang F, Broer S", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10698697", "url": "https://glygen.org/publication/PubMed/10698697" } ] }, { "title": "Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Fei YJ, Sugawara M, Nakanishi T, Huang W, Wang H, Prasad PD, Leibach FH, Ganapathy V", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10823827", "url": "https://glygen.org/publication/PubMed/10823827" } ] }, { "title": "Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity.", "journal": "Neuroscience letters", "date": "2000", "authors": "Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, Cha SH, Inatomi J, Shiokawa Y, Yamaguchi K, Saito I, Endou H, Kanai Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10863037", "url": "https://glygen.org/publication/PubMed/10863037" } ] }, { "title": "Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta.", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Wang H, Huang W, Sugawara M, Devoe LD, Leibach FH, Prasad PD, Ganapathy V", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10891391", "url": "https://glygen.org/publication/PubMed/10891391" } ] }, { "title": "The heterodimeric amino acid transporter 4F2hc/y+LAT2 mediates arginine efflux in exchange with glutamine.", "journal": "The Biochemical journal", "date": "2000", "authors": "Broer A, Wagner CA, Lang F, Broer S", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10903140", "url": "https://glygen.org/publication/PubMed/10903140" } ] }, { "title": "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.", "journal": "Biochimica et biophysica acta", "date": "2000", "authors": "Hatanaka T, Huang W, Wang H, Sugawara M, Prasad PD, Leibach FH, Ganapathy V", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "10930503", "url": "https://glygen.org/publication/PubMed/10930503" } ] }, { "title": "Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Nakanishi T, Sugawara M, Huang W, Martindale RG, Leibach FH, Ganapathy ME, Prasad PD, Ganapathy V", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "11243884", "url": "https://glygen.org/publication/PubMed/11243884" } ] }, { "title": "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "11278508", "url": "https://glygen.org/publication/PubMed/11278508" } ] }, { "title": "Human cystinuria-related transporter: localization and functional characterization.", "journal": "Kidney international", "date": "2001", "authors": "Mizoguchi K, Cha SH, Chairoungdua A, Kim DK, Shigeta Y, Matsuo H, Fukushima J, Awa Y, Akakura K, Goya T, Ito H, Endou H, Kanai Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "11318953", "url": "https://glygen.org/publication/PubMed/11318953" } ] }, { "title": "Evidence for the transport of neutral as well as cationic amino acids by ATA3, a novel and liver-specific subtype of amino acid transport system A.", "journal": "Biochimica et biophysica acta", "date": "2001", "authors": "Hatanaka T, Huang W, Ling R, Prasad PD, Sugawara M, Leibach FH, Ganapathy V", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "11342143", "url": "https://glygen.org/publication/PubMed/11342143" } ] }, { "title": "Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-.", "journal": "Pflugers Archiv : European journal of physiology", "date": "2001", "authors": "Bassi MT, Gasol E, Manzoni M, Pineda M, Riboni M, Martin R, Zorzano A, Borsani G, Palacin M", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "11417227", "url": "https://glygen.org/publication/PubMed/11417227" } ] }, { "title": "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues.", "journal": "Biochemistry", "date": "2001", "authors": "Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "11591158", "url": "https://glygen.org/publication/PubMed/11591158" } ] }, { "title": "The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location.", "journal": "Genomics", "date": "2002", "authors": "Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "11827462", "url": "https://glygen.org/publication/PubMed/11827462" } ] }, { "title": "Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes.", "journal": "The Journal of membrane biology", "date": "2002", "authors": "Furesz TC, Heath-Monnig E, Kamath SG, Smith CH", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "12202949", "url": "https://glygen.org/publication/PubMed/12202949" } ] }, { "title": "Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2.", "journal": "The Journal of physiology", "date": "2003", "authors": "Chen Z, Fei YJ, Anderson CM, Wake KA, Miyauchi S, Huang W, Thwaites DT, Ganapathy V", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "12527723", "url": "https://glygen.org/publication/PubMed/12527723" } ] }, { "title": "A cluster of proton/amino acid transporter genes in the human and mouse genomes.", "journal": "Genomics", "date": "2003", "authors": "Boll M, Foltz M, Rubio-Aliaga I, Daniel H", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "12809675", "url": "https://glygen.org/publication/PubMed/12809675" } ] }, { "title": "Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Babu E, Kanai Y, Chairoungdua A, Kim DK, Iribe Y, Tangtrongsup S, Jutabha P, Li Y, Ahmed N, Sakamoto S, Anzai N, Nagamori S, Endou H", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" }, { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" }, { "database": "RefSeq", "id": "NP_001185739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185739" } ], "reference": [ { "type": "PubMed", "id": "12930836", "url": "https://glygen.org/publication/PubMed/12930836" } ] }, { "title": "Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Gasol E, Jimenez-Vidal M, Chillaron J, Zorzano A, Palacin M", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "15151999", "url": "https://glygen.org/publication/PubMed/15151999" } ] }, { "title": "Identification of LAT4, a novel amino acid transporter with system L activity.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Bodoy S, Martin L, Zorzano A, Palacin M, Estevez R, Bertran J", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "15659399", "url": "https://glygen.org/publication/PubMed/15659399" } ] }, { "title": "Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule.", "journal": "Archives of pharmacal research", "date": "2005", "authors": "Park SY, Kim JK, Kim IJ, Choi BK, Jung KY, Lee S, Park KJ, Chairoungdua A, Kanai Y, Endou H, Kim DK", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "15918515", "url": "https://glygen.org/publication/PubMed/15918515" } ] }, { "title": "Amino acid transport across mammalian intestinal and renal epithelia.", "journal": "Physiological reviews", "date": "2008", "authors": "Broer S", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "18195088", "url": "https://glygen.org/publication/PubMed/18195088" } ] }, { "title": "Amino acid transporter LAT3 is required for podocyte development and function.", "journal": "J. Am. Soc. Nephrol.", "date": "2009", "authors": "Sekine Y, Nishibori Y, Akimoto Y, Kudo A, Ito N, Fukuhara D, Kurayama R, Higashihara E, Babu E, Kanai Y, Asanuma K, Nagata M, Majumdar A, Tryggvason K, Yan K", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "reference": [ { "type": "PubMed", "id": "19443642", "url": "https://glygen.org/publication/PubMed/19443642" } ] }, { "title": "Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis.", "journal": "Electrophoresis", "date": "2010", "authors": "Han G, Ye M, Liu H, Song C, Sun D, Wu Y, Jiang X, Chen R, Wang C, Wang L, Zou H", "evidence": [ { "database": "iPTMnet", "id": "O75387-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75387-1" } ], "reference": [ { "type": "PubMed", "id": "20166139", "url": "https://glygen.org/publication/PubMed/20166139" } ] }, { "title": "SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Pillai SM, Meredith D", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "21097500", "url": "https://glygen.org/publication/PubMed/21097500" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" }, { "database": "iPTMnet", "id": "O75387", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75387" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" }, { "database": "iPTMnet", "id": "O75387", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75387" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Porcelli V, Fiermonte G, Longo A, Palmieri F", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "24652292", "url": "https://glygen.org/publication/PubMed/24652292" } ] }, { "title": "Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Arriza JL, Kavanaugh MP, Fairman WA, Wu YN, Murdoch GH, North RA, Amara SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "8101838", "url": "https://glygen.org/publication/PubMed/8101838" } ] }, { "title": "Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.", "journal": "The Journal of biological chemistry", "date": "1993", "authors": "Shafqat S, Tamarappoo BK, Kilberg MS, Puranam RS, McNamara JO, Guadano-Ferraz A, Fremeau RT Jr", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "8340364", "url": "https://glygen.org/publication/PubMed/8340364" } ] }, { "title": "Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "8702519", "url": "https://glygen.org/publication/PubMed/8702519" } ] }, { "title": "ASCT-1 is a neutral amino acid exchanger with chloride channel activity.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Zerangue N, Kavanaugh MP", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "8910405", "url": "https://glygen.org/publication/PubMed/8910405" } ] }, { "title": "Human cationic amino acid transporters hCAT-1, hCAT-2A, and hCAT-2B: three related carriers with distinct transport properties.", "journal": "Biochemistry", "date": "1997", "authors": "Closs EI, Graf P, Habermeier A, Cunningham JM, Forstermann U", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "9174363", "url": "https://glygen.org/publication/PubMed/9174363" } ] }, { "title": "Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma.", "journal": "Urology", "date": "1997", "authors": "Chuaqui R F, Englert C R, Strup S E, Vocke C D, Zhuang Z, Duray P H, Bostwick D G, Linehan W M, Liotta L A, Emmert-Buck M R", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "reference": [ { "type": "PubMed", "id": "9255310", "url": "https://glygen.org/publication/PubMed/9255310" } ] }, { "title": "cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer.", "journal": "Genomics", "date": "1998", "authors": "Cole K A, Chuaqui R F, Katz K, Pack S, Zhuang Z, Cole C E, Lyne J C, Linehan W M, Liotta L A, Emmert-Buck M R", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "reference": [ { "type": "PubMed", "id": "9722952", "url": "https://glygen.org/publication/PubMed/9722952" } ] }, { "title": "Amino acid transport of y+L-type by heterodimers of 4F2hc/CD98 and members of the glycoprotein-associated amino acid transporter family.", "journal": "The EMBO journal", "date": "1999", "authors": "Pfeiffer R, Rossier G, Spindler B, Meier C, Kuhn L, Verrey F", "evidence": [ { "database": "Reactome", "id": "R-HSA-352230", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230" } ], "reference": [ { "type": "PubMed", "id": "9878049", "url": "https://glygen.org/publication/PubMed/9878049" } ] } ], "pathway": [ { "id": "hsa:8501", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8501", "resource": "KEGG Pathway" }, { "id": "R-HSA-352230", "name": "Amino acid transport across the plasma membrane", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-352230", "resource": "Reactome", "description": "Amino acid transport across the plasma membrane" } ], "orthologs": [ { "uniprot_canonical_ac": "B1WBX5-1", "protein_name": "Solute carrier family 43 member 1", "gene_name": "Slc43a1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"L-isoleucine transmembrane transporter activity", "id": "GO:0015188", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015188", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "pmid": "" }, { "name": "L-amino acid transmembrane transporter activity", "id": "GO:0015179", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015179", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "pmid": "" }, { "name": "amino acid transmembrane transporter activity", "id": "GO:0015171", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015171", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "pmid": "" }, { "name": "neutral L-amino acid transmembrane transporter activity", "id": "GO:0015175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015175", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "pmid": "" }, { "name": "L-leucine transmembrane transporter activity", "id": "GO:0015190", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015190", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "pmid": "" }, { "name": "L-valine transmembrane transporter activity", "id": "GO:0005304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005304", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "leucine transport", "id": "GO:0015820", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015820", "evidence": [ { "database": "UniProtKB", "id": "O75387", "url": "https://www.uniprot.org/uniprot/O75387" } ], "pmid": "" }, { "name": "amino acid transport", "id": "GO:0006865", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006865", "evidence": [ { 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