{ "uniprot_canonical_ac": "O75365-1", "uniprot_ac": "O75365", "uniprot_id": "TP4A3_HUMAN", "mass": { "chemical_mass": 19535.0, "monoisotopic_mass": 19535.0 }, "refseq": { "ac": "NP_009010", "name": "protein tyrosine phosphatase type IVA 3 isoform 2", "summary": "This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" }, "gene_names": [ { "name": "PTP4A3", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75365", "id": "O75365" }, { "name": "PRL-3; PRL-R; PRL3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010", "id": "NP_009010" }, { "name": "PRL3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75365", "id": "O75365" }, { "name": "PTP4A3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010", "id": "NP_009010" } ], "protein_names": [ { "name": "Protein tyrosine phosphatase type IVA 3", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75365" }, { "name": "3.1.3.48", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75365" }, { "name": "PRL-3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75365" }, { "name": "PRL-R", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75365" }, { "name": "Protein-tyrosine phosphatase 4a3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75365" }, { "name": "Protein-tyrosine phosphatase of regenerating liver 3", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75365" }, { "name": "potentially prenylated protein tyrosine phosphatase; protein-tyrosine phosphatase of regenerating liver 3; protein tyrosine phosphatase type IVA, member 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010", "id": "NP_009010" }, { "name": "protein tyrosine phosphatase type IVA 3 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010", "id": "NP_009010" } ], "function": [ { "annotation": "Data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" }, { "database": "PubMed", "id": "11598267", "url": "https://glygen.org/publication/PubMed/11598267" } ] }, { "annotation": "PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" }, { "database": "PubMed", "id": "34630392", "url": "https://glygen.org/publication/PubMed/34630392" } ] }, { "annotation": "Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365#function" }, { "database": "PubMed", "id": "11355880", "url": "https://glygen.org/publication/PubMed/11355880" }, { "database": "PubMed", "id": "12782572", "url": "https://glygen.org/publication/PubMed/12782572" } ] }, { "annotation": "Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" }, { "database": "PubMed", "id": "34482023", "url": "https://glygen.org/publication/PubMed/34482023" } ] }, { "annotation": "The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in Gastric Cancer and Mediates NF-kappaB Signaling by Regulating PRL-3 Expression.", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" }, { "database": "PubMed", "id": "36336860", "url": "https://glygen.org/publication/PubMed/36336860" } ] }, { "annotation": "The effects of endosulfan on cell migration and invasion in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis.", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" }, { "database": "PubMed", "id": "35817112", "url": "https://glygen.org/publication/PubMed/35817112" } ] }, { "annotation": "The phosphatase of regenerating liver-3 protein (PRL-3) promotes glioma cell invasiveness by interacting with beta3 -tubulin.", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" }, { "database": "PubMed", "id": "35098869", "url": "https://glygen.org/publication/PubMed/35098869" } ] }, { "annotation": "This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 104, "end_pos": 104, "sequence_org": "C", "sequence_mut": "A", "comment": "95% loss of enzymatic activity.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "PubMed", "id": "11355880", "url": "https://glygen.org/publication/PubMed/11355880" }, { "database": "PubMed", "id": "12782572", "url": "https://glygen.org/publication/PubMed/12782572" } ] }, { "start_pos": 104, "end_pos": 104, "sequence_org": "C", "sequence_mut": "S", "comment": "95% loss of enzymatic activity.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "PubMed", "id": "11355880", "url": "https://glygen.org/publication/PubMed/11355880" }, { "database": "PubMed", "id": "12782572", "url": "https://glygen.org/publication/PubMed/12782572" } ] }, { "start_pos": 104, "end_pos": 104, "sequence_org": "C", "sequence_mut": "S", "comment": "Reduces migration-promoting activity.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "PubMed", "id": "11355880", "url": "https://glygen.org/publication/PubMed/11355880" }, { "database": "PubMed", "id": "12782572", "url": "https://glygen.org/publication/PubMed/12782572" } ] }, { "start_pos": 111, "end_pos": 111, "sequence_org": "A", "sequence_mut": "S", "comment": "Enhances catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "PubMed", "id": "14704153", "url": "https://glygen.org/publication/PubMed/14704153" } ] }, { "start_pos": 49, "end_pos": 49, "sequence_org": "C", "sequence_mut": "A", "comment": "No effect on enzymatic activity.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "PubMed", "id": "14704153", "url": "https://glygen.org/publication/PubMed/14704153" } ] }, { "start_pos": 71, "end_pos": 71, "sequence_org": "D", "sequence_mut": "A", "comment": "No effect on enzymatic activity.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "PubMed", "id": "14704153", "url": "https://glygen.org/publication/PubMed/14704153" } ] }, { "start_pos": 72, "end_pos": 72, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolishes enzymatic activity.", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "PubMed", "id": "14704153", "url": "https://glygen.org/publication/PubMed/14704153" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "83.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "68.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "85.14", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "83.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "96.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "74.87", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "73.87", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "78.87", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "87.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "72.61", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "70.11", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.51", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "89.21", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184489", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184489" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": 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"https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": 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This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Esophageal cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:5041", "evidence": [ { "database": "BioXpress", "id": "O75365", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75365" } ], "disease": [ { "disease_id": "DOID:5041", "recommended_name": { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophageal cancer", "description": "A gastrointestinal system cancer that is located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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"MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM", "length": 87, "header": "tr|E5RFQ4-1|E5RFQ4_HUMAN Computationally mapped isoform of Protein tyrosine phosphatase 4A3 OS=Homo sapiens OX=9606 GN=PTP4A3 PE=1 SV=1 CANONICAL=O75365-1" }, "locus": { "chromosome": "8", "start_pos": 141431041, "end_pos": 141422241, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000524028.1", "url": "https://www.ensembl.org/id/ENST00000524028.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000430332.1", "url": "https://www.ensembl.org/id/ENSP00000430332.1" } ] } }, { "isoform_ac": "E5RGR3-1", "url": "", "sequence": { "sequence": "MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPF", "length": 70, "header": "tr|E5RGR3-1|TP4A3_HUMAN Computationally mapped isoform of Protein tyrosine phosphatase type IVA 3 OS=Homo sapiens OX=9606 GN=PTP4A3 PE=1 SV=1 CANONICAL=O75365-1" }, "locus": { "chromosome": "8", "start_pos": 141426950, "end_pos": 141422241, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000523147.5", "url": "https://www.ensembl.org/id/ENST00000523147.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428725.1", "url": "https://www.ensembl.org/id/ENSP00000428725.1" } ] } }, { "isoform_ac": "O75365-1", "url": "", "sequence": { "sequence": "MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM", "length": 173, "header": "sp|O75365-1|TP4A3_HUMAN Isoform 1 of Protein tyrosine phosphatase type IVA 3 OS=Homo sapiens OX=9606 GN=PTP4A3 PE=1 SV=2 CANONICAL=O75365-1" }, "locus": { "chromosome": "HG2031_PATCH", "start_pos": 97595, "end_pos": 88795, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000707616.1", "url": "https://www.ensembl.org/id/ENST00000707616.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000516927.1", "url": "https://www.ensembl.org/id/ENSP00000516927.1" } ] } }, { "isoform_ac": "O75365-2", "url": "", "sequence": { "sequence": "MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM", "length": 148, "header": "sp|O75365-2|TP4A3_HUMAN Isoform 2 of Protein tyrosine phosphatase type IVA 3 OS=Homo sapiens OX=9606 GN=PTP4A3 PE=1 SV=2 CANONICAL=O75365-1" }, "locus": { "chromosome": "HG2031_PATCH", "start_pos": 97595, "end_pos": 88795, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000707620.1", "url": "https://www.ensembl.org/id/ENST00000707620.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000516931.1", "url": "https://www.ensembl.org/id/ENSP00000516931.1" } ] } }, { "isoform_ac": "O75365-3", "url": "", "sequence": { "sequence": "MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM", "length": 87, "header": "sp|O75365-3|TP4A3_HUMAN Isoform 3 of Protein tyrosine phosphatase type IVA 3 OS=Homo sapiens OX=9606 GN=PTP4A3 PE=1 SV=2 CANONICAL=O75365-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 126, "end_pos": 126, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75365", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75365" }, { "database": "PubMed", "id": "23691193", "url": "https://glygen.org/publication/PubMed/23691193" } ], "site_lbl": "Tyr126" }, { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75365", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75365" }, { "database": "PubMed", "id": "23691193", "url": "https://glygen.org/publication/PubMed/23691193" } ], "site_lbl": "Tyr14" }, { "start_pos": 53, "end_pos": 53, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O75365", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75365" }, { "database": "PubMed", "id": "23691193", "url": "https://glygen.org/publication/PubMed/23691193" } ], "site_lbl": "Tyr53" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-II signaling.", "journal": "Biochemical and biophysical research communications", "date": "2001", "authors": "Matter WF, Estridge T, Zhang C, Belagaje R, Stancato L, Dixon J, Johnson B, Bloem L, Pickard T, Donaghue M, Acton S, Jeyaseelan R, Kadambi V, Vlahos CJ", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" } ], "reference": [ { "type": "PubMed", "id": "11355880", "url": "https://glygen.org/publication/PubMed/11355880" } ] }, { "title": "A phosphatase associated with metastasis of colorectal cancer.", "journal": "Science", "date": "2001", "authors": "Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" }, { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" } ], "reference": [ { "type": "PubMed", "id": "11598267", "url": "https://glygen.org/publication/PubMed/11598267" } ] }, { "title": "The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Wang J, Kirby CE, Herbst R", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" } ], "reference": [ { "type": "PubMed", "id": "12235145", "url": "https://glygen.org/publication/PubMed/12235145" } ] }, { "title": "Pentamidine is an inhibitor of PRL phosphatases with anticancer activity.", "journal": "Mol. Cancer Ther.", "date": "2002", "authors": "Pathak Manas K, Dhawan Deepika, Lindner Daniel J, Borden Ernest C, Farver Carol, Yi Taolin", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" } ], "reference": [ { "type": "PubMed", "id": "12516958", "url": "https://glygen.org/publication/PubMed/12516958" } ] }, { "title": "PRL-3 and PRL-1 promote cell migration, invasion, and metastasis.", "journal": "Cancer research", "date": "2003", "authors": "Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, Pallen CJ, Manser E, Hong W", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" } ], "reference": [ { "type": "PubMed", "id": "12782572", "url": "https://glygen.org/publication/PubMed/12782572" } ] }, { "title": "Structural insights into molecular function of the metastasis-associated phosphatase PRL-3.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kozlov G, Cheng J, Ziomek E, Banville D, Gehring K, Ekiel I", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" } ], "reference": [ { "type": "PubMed", "id": "14704153", "url": "https://glygen.org/publication/PubMed/14704153" } ] }, { "title": "Structure of human PRL-3, the phosphatase associated with cancer metastasis.", "journal": "FEBS Lett.", "date": "2004", "authors": "Kim Kyoung-Ah, Song Jin-Sue, Jee JunGoo, Sheen Mee Rie, Lee Chulhyun, Lee Tae Gyu, Ro Seonggu, Cho Joong Myung, Lee Weontae, Yamazaki Toshio, Jeon Young Ho, Cheong Chaejoon", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" } ], "reference": [ { "type": "PubMed", "id": "15135076", "url": "https://glygen.org/publication/PubMed/15135076" } ] }, { "title": "Src-mediated phosphorylation of the tyrosine phosphatase PRL-3 is required for PRL-3 promotion of Rho activation, motility and invasion.", "journal": "PloS one", "date": "2013", "authors": "Fiordalisi JJ, Dewar BJ, Graves LM, Madigan JP, Cox AD", "evidence": [ { "database": "iPTMnet", "id": "O75365", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75365" } ], "reference": [ { "type": "PubMed", "id": "23691193", "url": "https://glygen.org/publication/PubMed/23691193" } ] }, { "title": "Rag GTPases suppress PRL-3 degradation and predict poor clinical diagnosis of cancer patients with low PRL-3 mRNA expression.", "journal": "Biochemical and biophysical research communications", "date": "2021", "authors": "Shi Y, Xu S, Ngoi NYL, Hui Y, Ye Z", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" } ], "reference": [ { "type": "PubMed", "id": "34482023", "url": "https://glygen.org/publication/PubMed/34482023" } ] }, { "title": "PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Song Q, Zheng Y, Wu J, Wang S, Meng L, Yao Q, Li Z, Lian S", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" } ], "reference": [ { "type": "PubMed", "id": "34630392", "url": "https://glygen.org/publication/PubMed/34630392" } ] }, { "title": "The phosphatase of regenerating liver-3 protein (PRL-3) promotes glioma cell invasiveness by interacting with beta3 -tubulin.", "journal": "Bioengineered", "date": "2022", "authors": "Ge Z, Gu T, Zhang L, Fan Q, Ma L, Fang N", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" } ], "reference": [ { "type": "PubMed", "id": "35098869", "url": "https://glygen.org/publication/PubMed/35098869" } ] }, { "title": "The effects of endosulfan on cell migration and invasion in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis.", "journal": "The Science of the total environment", "date": "2022", "authors": "Wang Y, Guo Y, Lu Y, Sun Y, Xu D", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" } ], "reference": [ { "type": "PubMed", "id": "35817112", "url": "https://glygen.org/publication/PubMed/35817112" } ] }, { "title": "The Deubiquitinating Enzyme USP4 Functions as an Oncoprotein in Gastric Cancer and Mediates NF-\u03baB Signaling by Regulating PRL-3 Expression.", "journal": "Frontiers in bioscience (Landmark edition)", "date": "2022-10-19", "authors": "Tao Yuanyuan, You Wendao", "evidence": [ { "database": "RefSeq", "id": "NP_009010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009010" } ], "reference": [ { "type": "PubMed", "id": "36336860", "url": "https://glygen.org/publication/PubMed/36336860" } ] }, { "title": "Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38.", "journal": "Recept. Signal Transduct.", "date": "1997", "authors": "Dayton MA, Knobloch TJ", "evidence": [ { "database": "UniProtKB", "id": "O75365", "url": "https://www.uniprot.org/uniprot/O75365" } ], "reference": [ { "type": "PubMed", "id": "9633825", "url": "https://glygen.org/publication/PubMed/9633825" } ] } ], "pathway": [ { "id": "hsa:11156", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11156", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "B0K032-1", "protein_name": "Protein tyrosine phosphatase 4A3", "gene_name": "Ptp4a3", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MARMNRPAPVEVSYRHMRFLITHNPSNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLLKAKFYNDPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM", "length": 173 }, "evidence": [ { "id": "45923317", "url": "http://www.informatics.jax.org/homology/45923317", "database": "MGI" } ], "common_name": "Rat" }, { 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"3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6G7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6G7Q4" } ] } ] }, { "uniprot_ac": "A0A8I6GK94", "gene_name": "Ptprj", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6GK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK94" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6GK94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GK94" } ] } ] }, { "uniprot_ac": "A1L1L3", "gene_name": "Ptpn20", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A1L1L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1L3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A1L1L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1L1L3" } ] } ] }, { "uniprot_ac": "A1ZAB3", "gene_name": "Ptp52F", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A1ZAB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZAB3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A1ZAB3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A1ZAB3" } ] } ] }, { "uniprot_ac": "A2A8L5", "gene_name": "Ptprf", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2A8L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2A8L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2A8L5" } ] } ] }, { "uniprot_ac": "A2ALK8", "gene_name": "Ptpn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A2ALK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ALK8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A2ALK8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2ALK8" } ] } ] }, { "uniprot_ac": "A4D256", "gene_name": "CDC14C", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] } ] }, { "uniprot_ac": "A6HQ12", "gene_name": "Dusp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] } ] }, { "uniprot_ac": "A6NDG6", "gene_name": "PGP", "activity": [ { "ec_number": "3.1.3.21", "activity": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate.", "evidence": [ { "id": "A6NDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NDG6" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6NDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NDG6" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "A6NDG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6NDG6" } ] } ] }, { "uniprot_ac": "B0V2N1", "gene_name": "Ptprs", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B0V2N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0V2N1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B0V2N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0V2N1" } ] } ] }, { "uniprot_ac": "B1AUH1", "gene_name": "Ptpru", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B1AUH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AUH1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B1AUH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AUH1" } ] } ] }, { "uniprot_ac": "B2GV87", "gene_name": "Ptpre", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B2GV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV87" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B2GV87", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2GV87" } ] } ] }, { "uniprot_ac": "B2RU80", "gene_name": "Ptprb", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B2RU80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RU80" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B2RU80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RU80" } ] } ] }, { "uniprot_ac": "B2RZ50", "gene_name": "Cdkn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] } ] }, { "uniprot_ac": "B3EWF7", "gene_name": "EPM2A", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] } ] }, { "uniprot_ac": "B4F7B7", "gene_name": "Dusp15", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] } ] }, { "uniprot_ac": "B9EKR1", "gene_name": "Ptprz1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B9EKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B9EKR1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B9EKR1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B9EKR1" } ] } ] }, { "uniprot_ac": "D3ZBG7", "gene_name": "Dusp10", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBG7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D3ZBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBG7" } ] } ] }, { "uniprot_ac": "D3ZDK7", "gene_name": "Pgp", "activity": [ { "ec_number": "3.1.3.21", "activity": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate.", "evidence": [ { "id": "D3ZDK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZDK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK7" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "D3ZDK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "D3ZDK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDK7" } ] } ] }, { "uniprot_ac": "D3ZNK9", "gene_name": "Dusp8", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZNK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZNK9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D3ZNK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZNK9" } ] } ] }, { "uniprot_ac": "D3ZVI5", "gene_name": "Eya1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZVI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVI5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "D3ZVI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZVI5" } ] } ] }, { "uniprot_ac": "D4A3W6", "gene_name": "Dusp16", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D4A3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3W6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D4A3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3W6" } ] } ] }, { "uniprot_ac": "D4ADT2", "gene_name": "Cdc25c", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "D4ADT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "D4ADT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADT2" } ] } ] }, { "uniprot_ac": "E9Q0N2", "gene_name": "Ptprh", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E9Q0N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q0N2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E9Q0N2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q0N2" } ] } ] }, { "uniprot_ac": "E9Q612", "gene_name": "Ptpro", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "E9Q612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q612" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "E9Q612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q612" } ] } ] }, { "uniprot_ac": "F1LP13", "gene_name": "Ptprg", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1LP13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP13" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1LP13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LP13" } ] } ] }, { "uniprot_ac": "F1LQQ5", "gene_name": "Ptpn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "F1LQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQQ5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "F1LQQ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LQQ5" } ] } ] }, { "uniprot_ac": "G3V6B9", "gene_name": "Ptpn4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3V6B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6B9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3V6B9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6B9" } ] } ] }, { "uniprot_ac": "G3V7Q4", "gene_name": "Ptpn12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3V7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7Q4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3V7Q4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7Q4" } ] } ] }, { "uniprot_ac": "G3V9S3", "gene_name": "Ptpn13", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "G3V9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9S3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "G3V9S3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9S3" } ] } ] }, { "uniprot_ac": "O00167", "gene_name": "EYA2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O00167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00167" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O00167", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00167" } ] } ] }, { "uniprot_ac": "O08575", "gene_name": "Eya2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08575" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08575" } ] } ] }, { "uniprot_ac": "O08586", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] } ] }, { "uniprot_ac": "O08617", "gene_name": "Ptprr", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O08617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08617" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O08617", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08617" } ] } ] }, { "uniprot_ac": "O09112", "gene_name": "Dusp8", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] } ] }, { "uniprot_ac": "O14522", "gene_name": "PTPRT", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O14522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14522" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O14522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14522" } ] } ] }, { "uniprot_ac": "O35239", "gene_name": "Ptpn9", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O35239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35239" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O35239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35239" } ] } ] }, { "uniprot_ac": "O54838", "gene_name": "Dusp5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] } ] }, { "uniprot_ac": "O54857", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] } ] }, { "uniprot_ac": "O55082", "gene_name": "Ptpn20", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O55082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55082" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O55082", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55082" } ] } ] }, { "uniprot_ac": "O60729", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] } ] }, { "uniprot_ac": "O61722", "gene_name": "PRL-1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O61722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61722" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O61722", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61722" } ] } ] }, { "uniprot_ac": "O70274", "gene_name": "Ptp4a2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O70274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70274" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O70274", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70274" } ] } ] }, { "uniprot_ac": "O75061", "gene_name": "DNAJC6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O75061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75061" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O75061", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75061" } ] } ] }, { "uniprot_ac": "O75365", "gene_name": "PTP4A3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O75365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75365" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O75365", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75365" } ] } ] }, { "uniprot_ac": "O88488", "gene_name": "Ptprq", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O88488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88488" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O88488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88488" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O88488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88488" } ] } ] }, { "uniprot_ac": "O88902", "gene_name": "Ptpn23", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O88902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88902" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O88902", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88902" } ] } ] }, { "uniprot_ac": "O95147", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] } ] }, { "uniprot_ac": "O95677", "gene_name": "EYA4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O95677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95677" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O95677", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95677" } ] } ] }, { "uniprot_ac": "P04157", "gene_name": "Ptprc", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P04157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04157" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P04157", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04157" } ] } ] }, { "uniprot_ac": "P06800", "gene_name": "Ptprc", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P06800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06800" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P06800", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06800" } ] } ] }, { "uniprot_ac": "P08575", "gene_name": "PTPRC", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08575" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P08575", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08575" } ] } ] }, { "uniprot_ac": "P0C089", "gene_name": "Ptpmt1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] } ] }, { "uniprot_ac": "P0C595", "gene_name": "Dusp29", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] } ] }, { "uniprot_ac": "P0C5E4", "gene_name": "Ptprq", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P0C5E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5E4" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C5E4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C5E4" } ] } ] }, { "uniprot_ac": "P10586", "gene_name": "PTPRF", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P10586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10586" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P10586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10586" } ] } ] }, { "uniprot_ac": "P15309", "gene_name": "ACP3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P15309", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15309" } ] } ] }, { "uniprot_ac": "P16620", "gene_name": "Ptp69D", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16620" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16620" } ] } ] }, { "uniprot_ac": "P16621", "gene_name": "Lar", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P16621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16621" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P16621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16621" } ] } ] }, { "uniprot_ac": "P17706", "gene_name": "PTPN2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P17706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17706" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P17706", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17706" } ] } ] }, { "uniprot_ac": "P18031", "gene_name": "PTPN1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P18031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18031" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P18031", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18031" } ] } ] }, { "uniprot_ac": "P18052", "gene_name": "Ptpra", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P18052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18052" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P18052", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18052" } ] } ] }, { "uniprot_ac": "P18433", "gene_name": "PTPRA", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P18433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18433" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P18433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18433" } ] } ] }, { "uniprot_ac": "P20417", "gene_name": "Ptpn1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20417" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P20417", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20417" } ] } ] }, { "uniprot_ac": "P20483", "gene_name": "stg", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20483" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P20483", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20483" } ] } ] }, { "uniprot_ac": "P20646", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P20646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20646" } ] } ] }, { "uniprot_ac": "P23467", "gene_name": "PTPRB", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23467" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23467", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23467" } ] } ] }, { "uniprot_ac": "P23468", "gene_name": "PTPRD", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23468", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23468" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23468", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23468" } ] } ] }, { "uniprot_ac": "P23469", "gene_name": "PTPRE", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23469" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23469", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23469" } ] } ] }, { "uniprot_ac": "P23470", "gene_name": "PTPRG", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23470" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23470" } ] } ] }, { "uniprot_ac": "P23471", "gene_name": "PTPRZ1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23471" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23471", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23471" } ] } ] }, { "uniprot_ac": "P23748", "gene_name": "MIH1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P23748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23748" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P23748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23748" } ] } ] }, { "uniprot_ac": "P24666", "gene_name": "ACP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P24666", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24666" } ] } ] }, { "uniprot_ac": "P25044", "gene_name": "PTP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P25044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25044" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P25044", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25044" } ] } ] }, { "uniprot_ac": "P26045", "gene_name": "PTPN3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P26045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26045" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P26045", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26045" } ] } ] }, { "uniprot_ac": "P28562", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] } ] }, { "uniprot_ac": "P28563", "gene_name": "Dusp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] } ] }, { "uniprot_ac": "P28827", "gene_name": "PTPRM", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28827" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28827" } ] } ] }, { "uniprot_ac": "P28828", "gene_name": "Ptprm", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28828" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28828" } ] } ] }, { "uniprot_ac": "P29074", "gene_name": "PTPN4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29074" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29074", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29074" } ] } ] }, { "uniprot_ac": "P29349", "gene_name": "csw", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29349" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29349", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29349" } ] } ] }, { "uniprot_ac": "P29350", "gene_name": "PTPN6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29350" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29350" } ] } ] }, { "uniprot_ac": "P29351", "gene_name": "Ptpn6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29351" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29351" } ] } ] }, { "uniprot_ac": "P29352", "gene_name": "Ptpn22", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29352" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29352", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29352" } ] } ] }, { "uniprot_ac": "P29461", "gene_name": "PTP2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P29461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29461" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P29461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29461" } ] } ] }, { "uniprot_ac": "P30304", "gene_name": "CDC25A", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30304" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30304", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30304" } ] } ] }, { "uniprot_ac": "P30305", "gene_name": "CDC25B", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30305" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30305", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30305" } ] } ] }, { "uniprot_ac": "P30306", "gene_name": "Cdc25b", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30306" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30306" } ] } ] }, { "uniprot_ac": "P30307", "gene_name": "CDC25C", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P30307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30307" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P30307", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30307" } ] } ] }, { "uniprot_ac": "P34137", "gene_name": "ptpA1-2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P34137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34137" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P34137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34137" } ] } ] }, { "uniprot_ac": "P34138", "gene_name": "ptpB", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P34138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34138" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P34138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34138" } ] } ] }, { "uniprot_ac": "P35233", "gene_name": "Ptpn2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35233" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35233", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35233" } ] } ] }, { "uniprot_ac": "P35234", "gene_name": "Ptpn5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35234" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35234" } ] } ] }, { "uniprot_ac": "P35235", "gene_name": "Ptpn11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35235", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35235" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35235", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35235" } ] } ] }, { "uniprot_ac": "P35236", "gene_name": "PTPN7", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35236" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35236" } ] } ] }, { "uniprot_ac": "P35821", "gene_name": "Ptpn1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35821" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35821" } ] } ] }, { "uniprot_ac": "P35822", "gene_name": "Ptprk", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35822" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35822" } ] } ] }, { "uniprot_ac": "P35831", "gene_name": "Ptpn12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35831" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35831", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35831" } ] } ] }, { "uniprot_ac": "P35832", "gene_name": "Ptp99A", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35832" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35832" } ] } ] }, { "uniprot_ac": "P35992", "gene_name": "Ptp10D", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P35992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35992" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P35992", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35992" } ] } ] }, { "uniprot_ac": "P38148", "gene_name": "PPS1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] } ] }, { "uniprot_ac": "P38590", "gene_name": "MSG5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P38590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38590" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P38590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38590" } ] } ] }, { "uniprot_ac": "P40048", "gene_name": "PTP3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40048" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40048" } ] } ] }, { "uniprot_ac": "P40081", "gene_name": "", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40081" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40081" } ] } ] }, { "uniprot_ac": "P40347", "gene_name": "LTP1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P40347", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40347" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40347", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40347" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40347", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40347" } ] } ] }, { "uniprot_ac": "P40479", "gene_name": "SDP1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P40479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40479" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P40479", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40479" } ] } ] }, { "uniprot_ac": "P41498", "gene_name": "Acp1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "P41498", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41498" } ] } ] }, { "uniprot_ac": "P41499", "gene_name": "Ptpn11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P41499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41499" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P41499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41499" } ] } ] }, { "uniprot_ac": "P43378", "gene_name": "PTPN9", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P43378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43378" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P43378", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43378" } ] } ] }, { "uniprot_ac": "P48964", "gene_name": "Cdc25a", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48964" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48964", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48964" } ] } ] }, { "uniprot_ac": "P48965", "gene_name": "Cdc25a", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48965" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48965" } ] } ] }, { "uniprot_ac": "P48966", "gene_name": "Cdc25b", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48966" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48966" } ] } ] }, { "uniprot_ac": "P48967", "gene_name": "Cdc25c", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P48967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48967" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P48967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48967" } ] } ] }, { "uniprot_ac": "P49445", "gene_name": "Ptpn7", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P49445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49445" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P49445", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49445" } ] } ] }, { "uniprot_ac": "P49446", "gene_name": "Ptpre", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P49446", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49446" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P49446", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49446" } ] } ] }, { "uniprot_ac": "P50946", "gene_name": "OCA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P50946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50946" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P50946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50946" } ] } ] }, { "uniprot_ac": "P51452", "gene_name": "DUSP3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] } ] }, { "uniprot_ac": "P54637", "gene_name": "ptpC", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P54637", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54637" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P54637", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54637" } ] } ] }, { "uniprot_ac": "P54829", "gene_name": "PTPN5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P54829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54829" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P54829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54829" } ] } ] }, { "uniprot_ac": "P54830", "gene_name": "Ptpn5", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P54830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54830" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P54830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54830" } ] } ] }, { "uniprot_ac": "P56180", "gene_name": "TPTE", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P56180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56180" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P56180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P56180" } ] } ] }, { "uniprot_ac": "P60484", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] } ] }, { "uniprot_ac": "P70289", "gene_name": "Ptprv", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P70289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70289" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P70289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70289" } ] } ] }, { "uniprot_ac": "P80560", "gene_name": "Ptprn2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P80560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80560" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P80560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80560" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P80560", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80560" } ] } ] }, { "uniprot_ac": "P81718", "gene_name": "Ptpn6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P81718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P81718" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P81718", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P81718" } ] } ] }, { "uniprot_ac": "P82890", "gene_name": "primo-1", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P82890", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82890" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P82890", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82890" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P82890", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82890" } ] } ] }, { "uniprot_ac": "P82891", "gene_name": "primo-2", "activity": [ { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "P82891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82891" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P82891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82891" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P82891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P82891" } ] } ] }, { "uniprot_ac": "P97480", "gene_name": "Eya3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P97480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97480" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P97480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97480" } ] } ] }, { "uniprot_ac": "P97767", "gene_name": "Eya1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] } ] }, { "uniprot_ac": "Q00684", "gene_name": "CDC14", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q00684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00684" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q00684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00684" } ] } ] }, { "uniprot_ac": "Q02256", "gene_name": "YVH1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q02256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q02256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02256" } ] } ] }, { "uniprot_ac": "Q03019", "gene_name": "twe", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q03019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03019" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q03019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03019" } ] } ] }, { "uniprot_ac": "Q03348", "gene_name": "Ptpra", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q03348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03348" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q03348", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03348" } ] } ] }, { "uniprot_ac": "Q05201", "gene_name": "eya", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05201" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05201", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05201" } ] } ] }, { "uniprot_ac": "Q05209", "gene_name": "PTPN12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05209" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05209" } ] } ] }, { "uniprot_ac": "Q05909", "gene_name": "Ptprg", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05909" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05909", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05909" } ] } ] }, { "uniprot_ac": "Q05922", "gene_name": "Dusp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] } ] }, { "uniprot_ac": "Q05923", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] } ] }, { "uniprot_ac": "Q06124", "gene_name": "PTPN11", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q06124", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06124" } ] } ] }, { "uniprot_ac": "Q06180", "gene_name": "Ptpn2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q06180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06180" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q06180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06180" } ] } ] }, { "uniprot_ac": "Q12454", "gene_name": "OCA6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12454" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12454" } ] } ] }, { "uniprot_ac": "Q12913", "gene_name": "PTPRJ", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12913" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12913", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12913" } ] } ] }, { "uniprot_ac": "Q12923", "gene_name": "PTPN13", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12923" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12923" } ] } ] }, { "uniprot_ac": "Q12974", "gene_name": "PTP4A2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q12974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12974" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q12974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12974" } ] } ] }, { "uniprot_ac": "Q13115", "gene_name": "DUSP4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q13115", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13115" } ] } ] }, { "uniprot_ac": "Q13202", "gene_name": "DUSP8", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q13202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13202" } ] } ] }, { "uniprot_ac": "Q13332", "gene_name": "PTPRS", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13332" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13332" } ] } ] }, { "uniprot_ac": "Q13615", "gene_name": "MTMR3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "Q13615", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13615" } ] } ] }, { "uniprot_ac": "Q15256", "gene_name": "PTPRR", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q15256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q15256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15256" } ] } ] }, { "uniprot_ac": "Q15262", "gene_name": "PTPRK", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q15262", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15262" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q15262", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15262" } ] } ] }, { "uniprot_ac": "Q15678", "gene_name": "PTPN14", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q15678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15678" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q15678", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15678" } ] } ] }, { "uniprot_ac": "Q16667", "gene_name": "CDKN3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q16667", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16667" } ] } ] }, { "uniprot_ac": "Q16690", "gene_name": "DUSP5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q16690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16690" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q16690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16690" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q16690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16690" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q16690", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16690" } ] } ] }, { "uniprot_ac": "Q16825", "gene_name": "PTPN21", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q16825", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16825" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q16825", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16825" } ] } ] }, { "uniprot_ac": "Q16827", "gene_name": "PTPRO", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q16827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16827" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q16827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16827" } ] } ] }, { "uniprot_ac": "Q16828", "gene_name": "DUSP6", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q16828", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16828" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q16828", "database": "UniProtKB", "url": 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"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "Q5PQT2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5PQT2" } ] } ] }, { "uniprot_ac": "Q5SW75", "gene_name": "Ssh2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5SW75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5SW75" } ] } ] }, { "uniprot_ac": "Q5XIS1", "gene_name": "Ssh3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q5XIS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIS1" } ] } ] }, { "uniprot_ac": "Q61152", "gene_name": "Ptpn18", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q61152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61152" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q61152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61152" } ] } ] }, { "uniprot_ac": "Q62130", "gene_name": "Ptpn14", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62130" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62130", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62130" } ] } ] }, { "uniprot_ac": "Q62132", "gene_name": "Ptprr", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62132" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62132" } ] } ] }, { "uniprot_ac": "Q62136", "gene_name": "Ptpn21", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62136" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62136" } ] } ] }, { "uniprot_ac": "Q62656", "gene_name": "Ptprz1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62656" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62656" } ] } ] }, { "uniprot_ac": "Q62728", "gene_name": "Ptpn21", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62728" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62728" } ] } ] }, { "uniprot_ac": "Q62767", "gene_name": "Dusp4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62767" } ] } ] }, { "uniprot_ac": "Q62797", "gene_name": "Ptpro", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q62797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62797" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q62797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62797" } ] } ] }, { "uniprot_ac": "Q63340", "gene_name": "Dusp7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63340", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63340" } ] } ] }, { "uniprot_ac": "Q63475", "gene_name": "Ptprn2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q63475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63475" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63475" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63475" } ] } ] }, { "uniprot_ac": "Q63739", "gene_name": "Ptp4a1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63739" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63739" } ] } ] }, { "uniprot_ac": "Q63HR2", "gene_name": "TNS2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q63HR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HR2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q63HR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HR2" } ] } ] }, { "uniprot_ac": "Q641Z2", "gene_name": "Ptpn9", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q641Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641Z2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q641Z2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641Z2" } ] } ] }, { "uniprot_ac": "Q64346", "gene_name": "Dusp6", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q64346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64346" } ] } ] }, { "uniprot_ac": "Q64455", "gene_name": "Ptprj", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64455" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64455" } ] } ] }, { "uniprot_ac": "Q64487", "gene_name": "Ptprd", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64487" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64487" } ] } ] }, { "uniprot_ac": "Q64512", "gene_name": "Ptpn13", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64512" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64512", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64512" } ] } ] }, { "uniprot_ac": "Q64604", "gene_name": "Ptprf", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64604" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64604" } ] } ] }, { "uniprot_ac": "Q64605", "gene_name": "Ptprs", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64605" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64605", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64605" } ] } ] }, { "uniprot_ac": "Q64612", "gene_name": "Ptprv", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64612" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64612" } ] } ] }, { "uniprot_ac": "Q64623", "gene_name": "Dusp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] } ] }, { "uniprot_ac": "Q66GT5", "gene_name": "Ptpmt1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] } ] }, { "uniprot_ac": "Q68J44", "gene_name": "DUSP29", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q68J44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68J44" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q68J44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68J44" } ] } ] }, { "uniprot_ac": "Q6AXW7", "gene_name": "Dusp18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6AXW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6AXW7" } ] } ] }, { "uniprot_ac": "Q6B8I1", "gene_name": "DUSP13A", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6B8I1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6B8I1" } ] } ] }, { "uniprot_ac": "Q6GQT0", "gene_name": "Cdc14a", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6GQT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6GQT0" } ] } ] }, { "uniprot_ac": "Q6NN85", "gene_name": "ssh", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6NN85", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NN85" } ] } ] }, { "uniprot_ac": "Q6NT99", "gene_name": "Dusp23", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6NT99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NT99" } ] } ] }, { "uniprot_ac": "Q6P9X4", "gene_name": "Ptp4a2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6P9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P9X4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6P9X4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P9X4" } ] } ] }, { "uniprot_ac": "Q6PB44", "gene_name": "Ptpn23", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6PB44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PB44" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6PB44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PB44" } ] } ] }, { "uniprot_ac": "Q6PFY9", "gene_name": "Cdc14b", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q6PFY9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6PFY9" } ] } ] }, { "uniprot_ac": "Q76I76", "gene_name": "SSH2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q76I76", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I76" } ] } ] }, { "uniprot_ac": "Q76I79", "gene_name": "Ssh1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q76I79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76I79" } ] } ] }, { "uniprot_ac": "Q78EG7", "gene_name": "Ptp4a1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q78EG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78EG7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q78EG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78EG7" } ] } ] }, { "uniprot_ac": "Q7KMQ6", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] } ] }, { "uniprot_ac": "Q7TNL7", "gene_name": "Dusp9", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] } ] }, { "uniprot_ac": "Q80TZ3", "gene_name": "Dnajc6", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q80TZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TZ3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q80TZ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TZ3" } ] } ] }, { "uniprot_ac": "Q810P3", "gene_name": "Cdkn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] } ] }, { "uniprot_ac": "Q86BN8", "gene_name": "PTPMT1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] } ] }, { "uniprot_ac": "Q86IL4", "gene_name": "", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86IL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IL4" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q86IL4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86IL4" } ] } ] }, { "uniprot_ac": "Q86V88", "gene_name": "MDP1", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q86V88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V88" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86V88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V88" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q86V88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86V88" } ] } ] }, { "uniprot_ac": "Q8BFV3", "gene_name": "Dusp4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] } ] }, { "uniprot_ac": "Q8BGG7", "gene_name": "Ubash3b", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BGG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGG7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BGG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGG7" } ] } ] }, { "uniprot_ac": "Q8BK84", "gene_name": "Dusp29", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] } ] }, { "uniprot_ac": "Q8BTR5", "gene_name": "Dusp28", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] } ] }, { "uniprot_ac": "Q8BUM3", "gene_name": "Ptpn7", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BUM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BUM3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BUM3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BUM3" } ] } ] }, { "uniprot_ac": "Q8CE08", "gene_name": "Acp3", "activity": [ { "ec_number": "3.1.3.5", "activity": "a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate.", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] }, { "ec_number": "3.1.3.2", "activity": "a phosphate monoester + H2O = an alcohol + phosphate.", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] }, { "ec_number": "3.1.3.2", "activity": "", "evidence": [ { "id": "Q8CE08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE08" } ] } ] }, { "uniprot_ac": "Q8CGB6", "gene_name": "Tns2", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CGB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGB6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8CGB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGB6" } ] } ] }, { "uniprot_ac": "Q8CHP8", "gene_name": "Pgp", "activity": [ { "ec_number": "3.1.3.21", "activity": "H2O + sn-glycerol 3-phosphate = glycerol + phosphate.", "evidence": [ { "id": "Q8CHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHP8" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHP8" } ] }, { "ec_number": "3.1.3.21", "activity": "", "evidence": [ { "id": "Q8CHP8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHP8" } ] } ] }, { "uniprot_ac": "Q8K296", "gene_name": "Mtmr3", "activity": [ { "ec_number": "3.1.3.64", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.64", "activity": "", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] }, { "ec_number": "3.1.3.95", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate.", "evidence": [ { "id": "Q8K296", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K296" } ] } ] }, { "uniprot_ac": "Q8K330", "gene_name": "Ssh3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] } ] }, { "uniprot_ac": "Q8K4T5", "gene_name": "Dusp19", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] } ] }, { "uniprot_ac": "Q8NEJ0", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] } ] }, { "uniprot_ac": "Q8R4V2", "gene_name": "Dusp15", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] } ] }, { "uniprot_ac": "Q8T9S7", "gene_name": "pteN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] } ] }, { "uniprot_ac": "Q8TE77", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] } ] }, { "uniprot_ac": "Q8TF42", "gene_name": "UBASH3B", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TF42" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8TF42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TF42" } ] } ] }, { "uniprot_ac": "Q8VE01", "gene_name": "Dusp18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] } ] }, { "uniprot_ac": "Q8WTR2", "gene_name": "DUSP19", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] } ] }, { "uniprot_ac": "Q8WUK0", "gene_name": "PTPMT1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] } ] }, { "uniprot_ac": "Q8WYL5", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] } ] }, { "uniprot_ac": "Q91XQ2", "gene_name": "Epm2a", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] } ] }, { "uniprot_ac": "Q91XS1", "gene_name": "Mtmr4", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XS1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q91XS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XS1" } ] } ] }, { "uniprot_ac": "Q91Z46", "gene_name": "Dusp7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q91Z46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z46" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q91Z46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z46" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q91Z46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z46" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q91Z46", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91Z46" } ] } ] }, { "uniprot_ac": "Q92729", "gene_name": "PTPRU", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q92729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92729" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q92729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92729" } ] } ] }, { "uniprot_ac": "Q92932", "gene_name": "PTPRN2", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q92932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92932" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q92932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92932" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q92932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q92932" } ] } ] }, { "uniprot_ac": "Q93096", "gene_name": "PTP4A1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q93096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q93096" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q93096", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q93096" } ] } ] }, { "uniprot_ac": "Q99502", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] } ] }, { "uniprot_ac": "Q99504", "gene_name": "EYA3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q99504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99504" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99504" } ] } ] }, { "uniprot_ac": "Q99952", "gene_name": "PTPN18", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q99N11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99N11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] } ] }, { "uniprot_ac": "Q9BV47", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BV47", "database": 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"url": "https://www.uniprot.org/uniprot/Q9BVJ7" } ] } ] }, { "uniprot_ac": "Q9BY84", "gene_name": "DUSP16", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] } ] }, { "uniprot_ac": "Q9D0T2", "gene_name": "Dusp12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + 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"Q9D700", "gene_name": "Dusp26", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] } ] }, { "uniprot_ac": "Q9D7X3", "gene_name": "Dusp3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", 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