{ "uniprot_canonical_ac": "O75354-1", "uniprot_ac": "O75354", "uniprot_id": "ENTP6_HUMAN", "mass": { "chemical_mass": 53246.0, "monoisotopic_mass": 53246.0 }, "refseq": { "ac": "NP_001107561", "name": "ectonucleoside triphosphate diphosphohydrolase 6 isoform 2", "summary": "ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561" }, "gene_names": [ { "name": "ENTPD6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75354", "id": "O75354" }, { "name": "CD39L2; dJ738P15.3; IL-6SAG; IL6ST2; NTPDase-6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561", "id": "NP_001107561" }, { "name": "CD39L2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75354", "id": "O75354" }, { "name": "ENTPD6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561", "id": "NP_001107561" }, { "name": "IL6ST2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75354", "id": "O75354" } ], "protein_names": [ { "name": "Ectonucleoside triphosphate diphosphohydrolase 6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75354" }, { "name": "3.6.1.6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75354" }, { "name": "CD39 antigen-like 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75354" }, { "name": "NTPDase 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75354" }, { "name": "ectonucleoside triphosphate diphosphohydrolase 6 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561", "id": "NP_001107561" }, { "name": "interleukin 6 signal transducer-2; NTPDase 6; CD39 antigen-like 2; ectonucleoside triphosphate diphosphohydrolase 6 (putative)", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561", "id": "NP_001107561" } ], "function": [ { "annotation": "A secondary structural model of NTPDase-6 is proposed based on disulfide architecture (four conserved cysteine residues Cys249-Cys280 and Cys340-Cys354, circular dichroism data, and regions of conservation among all NTPDases.", "evidence": [ { "database": "RefSeq", "id": "NP_001107561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561" }, { "database": "PubMed", "id": "14529283", "url": "https://glygen.org/publication/PubMed/14529283" } ] }, { "annotation": "Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:14529283, PubMed:11041856). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:14529283, PubMed:11041856).", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354#function" }, { "database": "PubMed", "id": "11041856", "url": "https://glygen.org/publication/PubMed/11041856" }, { "database": "PubMed", "id": "14529283", "url": "https://glygen.org/publication/PubMed/14529283" }, { "database": "PubMed", "id": "10948193", "url": "https://glygen.org/publication/PubMed/10948193" } ] }, { "annotation": "ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001107561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561" } ] }, { "annotation": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001107561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561" }, { "database": "PubMed", "id": "20628086", "url": "https://glygen.org/publication/PubMed/20628086" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001107561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561" }, { "database": "PubMed", "id": "19913121", "url": "https://glygen.org/publication/PubMed/19913121" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs369231302", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs369231302" }, { "id": "rs369231302", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs369231302" }, { "id": "rs369231302", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs369231302" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 173, "end_pos": 173, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KAT->NAT).", "chr_id": "20", "chr_pos": "25213328", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K173", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs201609357", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201609357" }, { "id": "rs201609357", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs201609357" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 222, "end_pos": 222, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGT->NGI).", "chr_id": "20", "chr_pos": "25214934", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "T222", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs149104894", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149104894" }, { "id": "rs149104894", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs149104894" }, { "id": "rs149104894", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149104894" }, { "id": "rs149104894", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs149104894#frequency_tab" }, { "id": "rs149104894", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs149104894" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 284, "end_pos": 284, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRT->SRT).", "chr_id": "20", "chr_pos": "25217554", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "0.000399", "site_lbl": "N284", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs747977548", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747977548" }, { "id": "rs747977548", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs747977548" }, { "id": "rs747977548", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs747977548" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 286, "end_pos": 286, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NRT->NRN).", "chr_id": "20", "chr_pos": "25217560", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T286", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O75354", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75354" } ], "glycoeffect": [], "start_pos": 67, "end_pos": 67, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "20", "chr_pos": "25207220", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A67", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of 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cancer" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs755787165", "database": "dbSNP", "url": 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"url": "https://www.uniprot.org/uniprot/Q5QPJ4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5QPJ6", "url": "https://www.uniprot.org/uniprot/Q5QPJ6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5QPJ6-1", "url": "https://www.uniprot.org/uniprot/Q5QPJ6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5QPJ7", "url": "https://www.uniprot.org/uniprot/Q5QPJ7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "Q5QPJ7-1", "url": "https://www.uniprot.org/uniprot/Q5QPJ7-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS", "length": 484, "header": "sp|O75354-1|ENTP6_HUMAN Isoform 1 of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=3 CANONICAL=O75354-1" }, "isoforms": [ { "isoform_ac": "H0Y3D0-1", "url": "", "sequence": { "sequence": "XVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYGGSHLEREGTCLIPSVSDPGDTAAEQPLLMHGPHLRQPATPGVRLSQEQSAEAHSEN", "length": 295, "header": "tr|H0Y3D0-1|H0Y3D0_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=1 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25225514, "end_pos": 25213340, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376666.3", "url": "https://www.ensembl.org/id/ENST00000376666.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000365854.3", "url": "https://www.ensembl.org/id/ENSP00000365854.3" } ] } }, { "isoform_ac": "H0Y473-1", "url": "", "sequence": { "sequence": "XNRGVVSRGWRPGWRRPGRGSPKDRLPPAPRKRALVSVGVAERAVHETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGV", "length": 313, "header": "tr|H0Y473-1|ENTP6_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=8 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25222969, "end_pos": 25195730, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000433417.5", "url": "https://www.ensembl.org/id/ENST00000433417.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000390095.1", "url": "https://www.ensembl.org/id/ENSP00000390095.1" } ] } }, { "isoform_ac": "H0Y5X0-1", "url": "", "sequence": { "sequence": "XPGRGSPKDRLPPAPRKRALVSVGVAERAVHETPTLTHETFKALKPGLSAYADDVEKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSY", "length": 150, "header": "tr|H0Y5X0-1|H0Y5X0_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=1 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25217580, "end_pos": 25195775, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427553.5", "url": "https://www.ensembl.org/id/ENST00000427553.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000401573.1", "url": "https://www.ensembl.org/id/ENSP00000401573.1" } ] } }, { "isoform_ac": "H0Y6Q1-1", "url": "", "sequence": { "sequence": "XGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLK", "length": 311, "header": "tr|H0Y6Q1-1|H0Y6Q1_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=1 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25225317, "end_pos": 25207344, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000447877.5", "url": "https://www.ensembl.org/id/ENST00000447877.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000406975.1", "url": "https://www.ensembl.org/id/ENSP00000406975.1" } ] } }, { "isoform_ac": "O75354-1", "url": "", "sequence": { "sequence": "MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS", "length": 484, "header": "sp|O75354-1|ENTP6_HUMAN Isoform 1 of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=3 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25225594, "end_pos": 25206537, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376652.9", "url": "https://www.ensembl.org/id/ENST00000376652.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000365840.4", "url": "https://www.ensembl.org/id/ENSP00000365840.4" } ] } }, { "isoform_ac": "O75354-2", "url": "", "sequence": { "sequence": "MQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS", "length": 467, "header": "sp|O75354-2|ENTP6_HUMAN Isoform 2 of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=3 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25225594, "end_pos": 25195865, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000354989.9", "url": "https://www.ensembl.org/id/ENST00000354989.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000347084.5", "url": "https://www.ensembl.org/id/ENSP00000347084.5" } ] } }, { "isoform_ac": "O75354-3", "url": "", "sequence": { "sequence": "MKKGIRYETSRKTSYIFQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS", "length": 483, "header": "sp|O75354-3|ENTP6_HUMAN Isoform 3 of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=3 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25225594, "end_pos": 25206537, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000360031.6", "url": "https://www.ensembl.org/id/ENST00000360031.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000353131.2", "url": "https://www.ensembl.org/id/ENSP00000353131.2" } ] } }, { "isoform_ac": "Q5QPI7-1", "url": "", "sequence": { "sequence": "MPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSY", "length": 226, "header": "tr|Q5QPI7-1|Q5QPI7_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=1 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25217579, "end_pos": 25195865, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000417467.5", "url": "https://www.ensembl.org/id/ENST00000417467.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000395064.1", "url": "https://www.ensembl.org/id/ENSP00000395064.1" } ] } }, { "isoform_ac": "Q5QPI9-1", "url": "", "sequence": { "sequence": "MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYGGSHLEREGTCLIPSVSDPGDTAAEQPLLMHGPHLRQPATPGVRLSQEQSAEAHSEN", "length": 437, "header": "tr|Q5QPI9-1|Q5QPI9_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=2 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25225512, "end_pos": 25206537, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000433259.6", "url": "https://www.ensembl.org/id/ENST00000433259.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000401895.2", "url": "https://www.ensembl.org/id/ENSP00000401895.2" } ] } }, { "isoform_ac": "Q5QPJ3-1", "url": "", "sequence": { "sequence": "MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKA", "length": 300, "header": "tr|Q5QPJ3-1|Q5QPJ3_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=1 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25221332, "end_pos": 25206537, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000425813.5", "url": "https://www.ensembl.org/id/ENST00000425813.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000390646.1", "url": "https://www.ensembl.org/id/ENSP00000390646.1" } ] } }, { "isoform_ac": "Q5QPJ4-1", "url": "", "sequence": { "sequence": "MKKGIRYETSRKTSYIFQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLP", "length": 188, "header": "tr|Q5QPJ4-1|ENTP6_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=1 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25213376, "end_pos": 25206537, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000435520.5", "url": "https://www.ensembl.org/id/ENST00000435520.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000398844.1", "url": "https://www.ensembl.org/id/ENSP00000398844.1" } ] } }, { "isoform_ac": "Q5QPJ6-1", "url": "", "sequence": { "sequence": "MPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQP", "length": 296, "header": "tr|Q5QPJ6-1|ENTP6_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=2 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25218613, "end_pos": 25195865, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000439162.5", "url": "https://www.ensembl.org/id/ENST00000439162.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000408098.1", "url": "https://www.ensembl.org/id/ENSP00000408098.1" } ] } }, { "isoform_ac": "Q5QPJ7-1", "url": "", "sequence": { "sequence": "MQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQI", "length": 194, "header": "tr|Q5QPJ7-1|Q5QPJ7_HUMAN Computationally mapped isoform of Ectonucleoside triphosphate diphosphohydrolase 6 OS=Homo sapiens OX=9606 GN=ENTPD6 PE=1 SV=8 CANONICAL=O75354-1" }, "locus": { "chromosome": "20", "start_pos": 25216715, "end_pos": 25195865, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000418890.5", "url": "https://www.ensembl.org/id/ENST00000418890.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000390511.1", "url": "https://www.ensembl.org/id/ENSP00000390511.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "ETPTLTHETFK", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 126, "start_aa": "Glu", "end_pos": 136, "end_aa": "Lys", "evidence": [ { "id": "O75354", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "TPT", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 127, "start_aa": "Thr", "end_pos": 129, "end_aa": "Thr", "evidence": [ { "id": "O75354", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 182, "start_aa": "Thr", "end_pos": 182, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr182", "evidence": [ { "id": "O75354", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75354" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 220, "start_aa": "Asn", "end_pos": 220, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn220", "evidence": [ { "id": "O75354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75354#ptm_processing" }, { "id": "14529283", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/14529283" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 284, "start_aa": "Asn", "end_pos": 284, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn284", "evidence": [ { "id": "O75354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75354#ptm_processing" }, { "id": "14529283", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/14529283" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "GQQAHSPLGTAADGHEVF", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 84, "start_aa": "Gly", "end_pos": 101, "end_aa": "Phe", "evidence": [ { "id": "O75354", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": 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"authors": "Mulero JJ, Yeung G, Nelken ST, Bright JM, McGowan DW, Ford JE", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "11041857", "url": "https://glygen.org/publication/PubMed/11041857" } ] }, { "title": "Molecular cloning and characterization of a novel mammalian endo-apyrase (LALP1).", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Shi JD, Kukar T, Wang CY, Li QZ, Cruz PE, Davoodi-Semiromi A, Yang P, Gu Y, Lian W, Wu DH, She JX", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "11278936", "url": "https://glygen.org/publication/PubMed/11278936" } ] }, { "title": "CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness.", "journal": "Nature medicine", "date": "2002", "authors": "Mizumoto N, Kumamoto T, Robson SC, Sevigny J, Matsue H, Enjyoji K, Takashima A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "11927941", "url": "https://glygen.org/publication/PubMed/11927941" } ] }, { "title": "Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation.", "journal": "Blood", "date": "2002", "authors": "Sevigny J, Sundberg C, Braun N, Guckelberger O, Csizmadia E, Qawi I, Imai M, Zimmermann H, Robson SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "11929769", "url": "https://glygen.org/publication/PubMed/11929769" } ] }, { "title": "Determination of native oligomeric state and substrate specificity of rat NTPDase1 and NTPDase2 after heterologous expression in Xenopus oocytes.", "journal": "European journal of biochemistry", "date": "2003", "authors": "Failer BU, Aschrafi A, Schmalzing G, Zimmermann H", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "12694193", "url": "https://glygen.org/publication/PubMed/12694193" } ] }, { "title": "Requirement of Cys399 for processing of the human ecto-ATPase (NTPDase2) and its implications for determination of the activities of splice variants of the enzyme.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Mateo J, Kreda S, Henry CE, Harden TK, Boyer JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "12888562", "url": 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by CD39 (NTPDase-1).", "journal": "Journal of thrombosis and haemostasis : JTH", "date": "2003", "authors": "Marcus AJ, Broekman MJ, Drosopoulos JH, Islam N, Pinsky DJ, Sesti C, Levi R", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "14675084", "url": "https://glygen.org/publication/PubMed/14675084" } ] }, { "title": "Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-8.", "journal": "Biochemistry", "date": "2004", "authors": "Bigonnesse F, Levesque SA, Kukulski F, Lecka J, Robson SC, Fernandes MJ, Sevigny J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "15122917", "url": "https://glygen.org/publication/PubMed/15122917" } ] }, { "title": "Cloning and characterization of mouse nucleoside triphosphate diphosphohydrolase-3.", "journal": "Biochemical pharmacology", "date": "2004", "authors": "Lavoie EG, Kukulski F, Levesque SA, Lecka J, Sevigny J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "15130768", "url": "https://glygen.org/publication/PubMed/15130768" } ] }, { "title": "Immunolocalization of ecto-nucleoside triphosphate diphosphohydrolase 3 in rat brain: implications for modulation of multiple homeostatic systems including feeding and sleep-wake behaviors.", "journal": "Neuroscience", "date": "2006", "authors": "Belcher SM, Zsarnovszky A, Crawford PA, Hemani H, Spurling L, Kirley TL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "16338080", "url": "https://glygen.org/publication/PubMed/16338080" } ] }, { "title": "Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8.", "journal": "American journal of physiology. Gastrointestinal and liver physiology", "date": "2007", "authors": "Fausther M, Lecka J, Kukulski F, Levesque SA, Pelletier J, Zimmermann H, Dranoff JA, Sevigny J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "17095758", "url": "https://glygen.org/publication/PubMed/17095758" } ] }, { "title": "Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.", "journal": "The Journal of experimental medicine", "date": "2007", "authors": "Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "17502665", "url": "https://glygen.org/publication/PubMed/17502665" } ] }, { "title": "Comparative hydrolysis of P2 receptor agonists by NTPDases 1, 2, 3 and 8.", "journal": "Purinergic signalling", "date": "2005", "authors": "Kukulski F, Levesque SA, Lavoie EG, Lecka J, Bigonnesse F, Knowles AF, Robson SC, Kirley TL, Sevigny J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "18404504", "url": "https://glygen.org/publication/PubMed/18404504" } ] }, { "title": "Cloning and characterization of the ecto-nucleotidase NTPDase3 from rat brain: Predicted secondary structure and relation to other members of the E-NTPDase family and actin.", "journal": "Purinergic signalling", "date": "2005", "authors": "Vorhoff T, Zimmermann H, Pelletier J, Sevigny J, Braun N", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "18404510", "url": "https://glygen.org/publication/PubMed/18404510" } ] }, { "title": "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.", "journal": "Analytical chemistry", "date": "2008", "authors": "Wang B, Malik R, Nigg EA, Korner R", "evidence": [ { "database": "iPTMnet", "id": "O75354-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75354-1" } ], "reference": [ { "type": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" } ] }, { "title": "NTPDase1 (CD39) controls nucleotide-dependent vasoconstriction in mouse.", "journal": "Cardiovascular research", "date": "2010", "authors": "Kauffenstein G, Drouin A, Thorin-Trescases N, Bachelard H, Robaye B, D'Orleans-Juste P, Marceau F, Thorin E, Sevigny J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "19640930", "url": "https://glygen.org/publication/PubMed/19640930" } ] }, { "title": "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.", "journal": "American journal of human genetics", "date": "2009", "authors": "Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD", "evidence": [ { "database": "RefSeq", "id": "NP_001107561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561" } ], "reference": [ { "type": "PubMed", "id": "19913121", "url": "https://glygen.org/publication/PubMed/19913121" } ] }, { "title": "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.", "journal": "Diabetes care", "date": "2010", "authors": "Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S", "evidence": [ { "database": "RefSeq", "id": "NP_001107561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107561" } ], "reference": [ { "type": "PubMed", "id": "20628086", "url": "https://glygen.org/publication/PubMed/20628086" } ] }, { "title": "Identification of the ectonucleotidases expressed in mouse, rat, and human Langerhans islets: potential role of NTPDase3 in insulin secretion.", "journal": "American journal of physiology. Endocrinology and metabolism", "date": "2010", "authors": "Lavoie EG, Fausther M, Kauffenstein G, Kukulski F, Kunzli BM, Friess H, Sevigny J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "20682839", "url": "https://glygen.org/publication/PubMed/20682839" } ] }, { "title": "The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway.", "journal": "Cell", "date": "2010", "authors": "Fang M, Shen Z, Huang S, Zhao L, Chen S, Mak TW, Wang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "21074248", "url": "https://glygen.org/publication/PubMed/21074248" } ] }, { "title": "Impact of ectoenzymes on p2 and p1 receptor signaling.", "journal": "Advances in pharmacology (San Diego, Calif.)", "date": "2011", "authors": "Kukulski F, Levesque SA, Sevigny J", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "21586362", "url": "https://glygen.org/publication/PubMed/21586362" } ] }, { "title": "ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells.", "journal": "Cold Spring Harbor symposia on quantitative biology", "date": "2011", "authors": "Shen Z, Huang S, Fang M, Wang X", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "22169232", "url": "https://glygen.org/publication/PubMed/22169232" } ] }, { "title": "Ecto-nucleoside triphosphate diphosphohydrolase 7 controls Th17 cell responses through regulation of luminal ATP in the small intestine.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2013", "authors": "Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "23241884", "url": "https://glygen.org/publication/PubMed/23241884" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "O75354", "url": "" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.", "journal": "Molecular & cellular proteomics : MCP", "date": "2015", "authors": "Campos D, Freitas D, Gomes J, Magalhaes A, Steentoft C, Gomes C, Vester-Christensen MB, Ferreira JA, Afonso LP, Santos LL, Pinto de Sousa J, Mandel U, Clausen H, Vakhrushev SY, Reis CA", "evidence": [ { "database": "UniCarbKB", "id": "O75354", "url": "" } ], "reference": [ { "type": "PubMed", "id": "25813380", "url": "https://glygen.org/publication/PubMed/25813380" } ] }, { "title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).", "journal": "Molecular systems biology", "date": "2018", "authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "O75354", "url": "" } ], "reference": [ { "type": "PubMed", "id": "30459171", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75354", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75354" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "Identification and characterization of CD39/vascular ATP diphosphohydrolase.", "journal": "The Journal of biological chemistry", "date": "1996", "authors": "Kaczmarek E, Koziak K, Sevigny J, Siegel JB, Anrather J, Beaudoin AR, Bach FH, Robson SC", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "8955160", "url": "https://glygen.org/publication/PubMed/8955160" } ] }, { "title": "Complementary DNA cloning and sequencing of the chicken muscle ecto-ATPase. Homology with the lymphoid cell activation antigen CD39.", "journal": "The Journal of biological chemistry", "date": "1997", "authors": "Kirley TL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "8995405", "url": "https://glygen.org/publication/PubMed/8995405" } ] }, { "title": "An ecto-ATPase and an ecto-ATP diphosphohydrolase are expressed in rat brain.", "journal": "Neuropharmacology", "date": "1997", "authors": "Kegel B, Braun N, Heine P, Maliszewski CR, Zimmermann H", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "9364474", "url": "https://glygen.org/publication/PubMed/9364474" } ] }, { "title": "Golgi localization and functional expression of human uridine diphosphatase.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Wang TF, Guidotti G", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "9556635", "url": "https://glygen.org/publication/PubMed/9556635" } ] }, { "title": "Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1.", "journal": "Biochimica et biophysica acta", "date": "1998", "authors": "Smith TM, Kirley TL", "evidence": [ { "database": "Reactome", "id": "R-HSA-8850843", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843" } ], "reference": [ { "type": "PubMed", "id": "9675246", "url": "https://glygen.org/publication/PubMed/9675246" } ] }, { "title": "The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster.", "journal": "Genomics", "date": "1998", "authors": "Chadwick BP, Frischauf AM", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "reference": [ { "type": "PubMed", "id": "9676430", "url": "https://glygen.org/publication/PubMed/9676430" } ] } ], "pathway": [ { "id": "hsa:955", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:955", "resource": "KEGG Pathway" }, { "id": "R-HSA-8850843", "name": "Phosphate bond hydrolysis by NTPDase proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8850843", "resource": "Reactome", "description": "Phosphate bond hydrolysis by NTPDase proteins" } ], "orthologs": [ { "uniprot_canonical_ac": "Q3U0P5-1", "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 6", "gene_name": "Entpd6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MRKIPNHGTLRMTKVAYPLGLCVGLFIYVAYIKWHRASAAQAFFTIAGAASGARWTQQAFSSPGSAARGHEVFYGIMFDAGSTGTRIHVFQFARPPGETPTLTHETFKALKPGLSAYADDVEKSAQGIQELLNVAKQHIPYDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKEVFKASPFLVGDDCVSIMNGTDEGVSAWITVNFLTGSLKTPGSSSVGMLDLGGGSTQITFLPRVEGTLQASPPGHLTALQMFNRTYKLYSYSYLGLGLMSARLAILGGVEGKPAENDKELVSPCLSPRFRGEWEHAEVTYRISGQKAVGLYELCASRVSEVLRNKVHRTEEAQHVDFYAFSYYYDLAASFGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPPSSPFACMDLTYISLLLHEFGFPGDKVLKLARKIDNVETSWALGAIFHYIDSLKRQKVPAL", "length": 455 }, "evidence": [ { "id": "45929629", "url": "http://www.informatics.jax.org/homology/45929629", "database": "MGI" }, { "id": "O75354", "url": "https://omabrowser.org/oma/group/O75354/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9ER31-1", "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 6", "gene_name": "Entpd6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "GDP phosphatase activity", "id": "GO:0004382", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004382", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "UDP phosphatase activity", "id": "GO:0045134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045134", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity", "id": "GO:0008894", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008894", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "nucleoside diphosphate phosphatase activity", "id": "GO:0017110", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017110", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "ribonucleoside triphosphate phosphatase activity", "id": "GO:0017111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017111", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "IDP phosphatase activity", "id": "GO:1990003", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990003", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "CDP phosphatase activity", "id": "GO:0036384", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036384", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "cell surface", "id": "GO:0009986", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "response to calcium ion", "id": "GO:0051592", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051592", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "response to magnesium ion", "id": "GO:0032026", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032026", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" }, { "name": "nucleoside diphosphate catabolic process", "id": "GO:0009134", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009134", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "ectonucleoside triphosphate diphosphohydrolase 6 O-glycosylated 1 (human)", "definition": "An ectonucleoside triphosphate diphosphohydrolase 6 (human) that has been O-glycosylated at the residue equivalent to Thr-93 of the amino acid sequence represented by UniProtKB:O75354-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O75354-1, Thr-93, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050831", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050831" } ] } ], "site_annotation": [ { "start_pos": 220, "end_pos": 222, "annotation": "n_glycosylation_sequon" }, { "start_pos": 284, "end_pos": 286, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" }, { "database": "PubMed", "id": "11041856", "url": "https://glygen.org/publication/PubMed/11041856" }, { "database": "PubMed", "id": "10948193", "url": "https://glygen.org/publication/PubMed/10948193" } ] }, { "annotation": "The secreted form may be produced by intracellular processing.", "evidence": [ { "database": "UniProtKB", "id": "O75354", "url": "https://www.uniprot.org/uniprot/O75354" }, { "database": "PubMed", "id": "11041856", "url": "https://glygen.org/publication/PubMed/11041856" } ] } ], "interactions": [], "reactions": [ { "id": "22156", "name": "", "equation": "GDP + H2O = GMP + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ER31-1", "Q6P6S9-1", "P97687-1", "Q9Y227-1", "O75354-1", "P32455-1", "Q8N8V2-1", "O75356-1", "P49961-1", "Q3U0P5-1", "Q9DBT4-1", "Q01514-1", "Q91Z40-1", "Q9WUZ9-1", "P55772-1", "P32621-1" ], "evidence": [ { "id": "22156", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/22156" } ] }, { "id": "35207", "name": "", "equation": "H2O + IDP = H(+) + IMP + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ER31-1", "Q6P6S9-1", "G3V7P6-1", "P97687-1", "Q96DE0-1", "O75354-1", "O75356-1", "P49961-1", "Q6P3D0-1", "Q3U0P5-1", "Q9WUZ9-1", "E9Q9G1-1", "P55772-1" ], "evidence": [ { "id": "35207", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/35207" } ] }, { "id": "36799", "name": "", "equation": "a ribonucleoside 5'-diphosphate + H2O = a ribonucleoside 5'-phosphate + H(+) + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4Y7-1", "Q6P6S9-1", "Q9ER31-1", "P97687-1", "Q8WVQ1-1", "Q9Y227-1", "O75356-1", "O75354-1", "P49961-1", "Q8VCF1-1", "Q9WUZ9-1", "Q9DBT4-1", "Q3U0P5-1", "P55772-1" ], "evidence": [ { "id": "36799", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/36799" } ] }, { "id": "64876", "name": "", "equation": "H2O + UDP = H(+) + phosphate + UMP", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9ER31-1", "Q6P6S9-1", "P97687-1", "Q9Y227-1", "O75354-1", "O75356-1", "P49961-1", "Q3U0P5-1", "Q9DBT4-1", "Q9WUZ9-1", "P55772-1" ], "evidence": [ { "id": "64876", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/64876" } ] }, { "id": "R-HSA-8851396", "name": "NTPDase6 hydrolyzes nucleoside diphosphates", "equation": "", "summary": "NTPDase6 (CD39L2), encoded by the ENTPD6 gene, is an ectonucleotide phosphatase of the E-NTPDase family that can be secreted (Yeung et al. 2000). Secretion involves the removal of the first 77 amino acids at the N-terminus by an unknown peptidase. Secreted NTPDase6 hydrolyzes nucleoside diphosphates GDP, IDP and, less efficiently, UDP and CDP to nucleoside monophosphates GMP, IMP, UMP and CMP, respectively. Secreted NTPDase6 hydrolyzes ADP to AMP and nucleoside triphosphates GTP, ITP, UTP and CTP to corresponding nucleoside diphosphates with very low efficacy (Hicks-Berger et al. 2000, Yeung et al. 2000, Ivanenkov et al. 2003). NTPDase6 requires Ca2+ or Mg2+ for catalytic activity (Hicks-Berger et al. 2000, Ivanenkov et al. 2003).

NTPDase6 may also be able to function as a membrane-bound enzyme, but its catalytic rate is very low and accounts for up to 10% of NTPDase6 activity (Hicks-Berger et al. 2000).", "cellular_location": "extracellular region", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O75354-1" ], "evidence": [ { "id": "R-HSA-8851396", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8851396" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "E9Q9G1", "gene_name": "Nudt16l2", "activity": [ { "ec_number": "3.6.1.62", "activity": "a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + 2 H(+) + N(7)-methyl-GDP.", "evidence": [ { "id": "E9Q9G1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q9G1" } ] }, { "ec_number": "3.6.1.64", "activity": "H2O + IDP = H(+) + IMP + phosphate.", "evidence": [ { "id": "E9Q9G1", "database": 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