{ "uniprot_canonical_ac": "O75344-1", "uniprot_ac": "O75344", "uniprot_id": "FKBP6_HUMAN", "mass": { "chemical_mass": 37214.0, "monoisotopic_mass": 37214.0 }, "refseq": { "ac": "NP_001128683", "name": "inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform b", "summary": "The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683" }, "gene_names": [ { "name": "FKBP6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75344", "id": "O75344" }, { "name": "FKBP36; SPGF77", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683", "id": "NP_001128683" }, { "name": "FKBP36", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75344", "id": "O75344" }, { "name": "FKBP6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683", "id": "NP_001128683" } ], "protein_names": [ { "name": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75344" }, { "name": "36 kDa FK506-binding protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75344" }, { "name": "36 kDa FKBP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75344" }, { "name": "FK506-binding protein 6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75344" }, { "name": "FKBP-36", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75344" }, { "name": "FKBP-6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75344" }, { "name": "Immunophilin FKBP36", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75344" }, { "name": "Inactive PPIase FKBP6", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75344" }, { "name": "inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683", "id": "NP_001128683" }, { "name": "rotamase; immunophilin FKBP36; peptidyl-prolyl cis-trans isomerase FKBP6; 36 kDa FKBP; PPIase FKBP6; inactive PPIase FKBP6; inactive peptidyl-prolyl cis-trans isomerase FKBP6; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683", "id": "NP_001128683" } ], "function": [ { "annotation": "Has an essential role in spermatogenesis (PubMed:36150389). It is required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis (By similarity). May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344#function" }, { "database": "PubMed", "id": "36150389", "url": "https://glygen.org/publication/PubMed/36150389" }, { "database": "UniProtKB", "id": "Q91XW8", "url": "https://www.uniprot.org/uniprot/Q91XW8#function" } ] }, { "annotation": "The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.", "evidence": [ { "database": "RefSeq", "id": "NP_001128683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683" }, { "database": "PubMed", "id": "36150389", "url": "https://glygen.org/publication/PubMed/36150389" } ] }, { "annotation": "The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].", "evidence": [ { "database": "RefSeq", "id": "NP_001128683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683" } ] } ], "disease": [ { "disease_id": "MONDO:0031083", "recommended_name": { "id": "MONDO:0031083", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031083", "name": "spermatogenic failure 77", "description": "" }, "synonyms": [ { "id": "MONDO:0031083", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031083", "name": "SPGF77", "description": "" }, { "id": "MONDO:0031083", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0031083", "name": "spermatogenic failure 77", "description": "" }, { "id": "MIM:620103", "resource": "MIM", "url": "https://www.omim.org/entry/620103", "name": "Spermatogenic failure 77", "description": "Spermatogenic failure 77" } ], "evidence": [ { "id": "620103", "database": "MIM", "url": "https://www.omim.org/entry/620103" } ] } ], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "54.17", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "58.69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "51.61", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "80.74", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "55.59", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "49.15", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "67.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "54.28", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "53.61", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "65", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "43.7", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "57", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "57.64", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000077800", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000077800" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O75344", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75344" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O75344", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75344" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGDGSTAGES", "length": 327, "header": "sp|O75344-1|FKBP6_HUMAN Isoform 1 of Inactive peptidyl-prolyl cis-trans isomerase FKBP6 OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "isoforms": [ { "isoform_ac": "A0A3B3IST2-1", "url": "", "sequence": { "sequence": "MSASSWPQNGMPPSSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQFSPWDRLVFS", "length": 266, "header": "tr|A0A3B3IST2-1|A0A3B3IST2_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "locus": { "chromosome": "7", "start_pos": 73341285, "end_pos": 73328273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000648538.1", "url": "https://www.ensembl.org/id/ENST00000648538.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000497448.1", "url": "https://www.ensembl.org/id/ENSP00000497448.1" } ] } }, { "isoform_ac": "C9JM01-1", "url": "", "sequence": { "sequence": "MSASSWPQNGMPPSSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLA", "length": 252, "header": "tr|C9JM01-1|C9JM01_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "locus": { "chromosome": "7", "start_pos": 73341380, "end_pos": 73328273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000442793.5", "url": "https://www.ensembl.org/id/ENST00000442793.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000402360.1", "url": "https://www.ensembl.org/id/ENSP00000402360.1" } ] } }, { "isoform_ac": "F8WD36-1", "url": "", "sequence": { "sequence": "MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKAPCWVCCG", "length": 199, "header": "tr|F8WD36-1|F8WD36_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "locus": { "chromosome": "7", "start_pos": 73336782, "end_pos": 73328429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000429879.5", "url": "https://www.ensembl.org/id/ENST00000429879.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000403908.1", "url": "https://www.ensembl.org/id/ENSP00000403908.1" } ] } }, { "isoform_ac": "F8WD38-1", "url": "", "sequence": { "sequence": "MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEGRFRVGAGEEGIV", "length": 101, "header": "tr|F8WD38-1|F8WD38_HUMAN Computationally mapped isoform of peptidylprolyl isomerase OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "locus": { "chromosome": "7", "start_pos": 73329487, "end_pos": 73328429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000445032.5", "url": "https://www.ensembl.org/id/ENST00000445032.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000415891.1", "url": "https://www.ensembl.org/id/ENSP00000415891.1" } ] } }, { "isoform_ac": "O75344-1", "url": "", "sequence": { "sequence": "MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGDGSTAGES", "length": 327, "header": "sp|O75344-1|FKBP6_HUMAN Isoform 1 of Inactive peptidyl-prolyl cis-trans isomerase FKBP6 OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "locus": { "chromosome": "7", "start_pos": 73342894, "end_pos": 73328429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000252037.5", "url": "https://www.ensembl.org/id/ENST00000252037.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000252037.4", "url": "https://www.ensembl.org/id/ENSP00000252037.4" } ] } }, { "isoform_ac": "O75344-2", "url": "", "sequence": { "sequence": "MSASSWPQNGMPPSSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGDGSTAGES", "length": 322, "header": "sp|O75344-2|FKBP6_HUMAN Isoform 2 of Inactive peptidyl-prolyl cis-trans isomerase FKBP6 OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "locus": { "chromosome": "7", "start_pos": 73342894, "end_pos": 73328273, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000431982.6", "url": "https://www.ensembl.org/id/ENST00000431982.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000416277.2", "url": "https://www.ensembl.org/id/ENSP00000416277.2" } ] } }, { "isoform_ac": "O75344-3", "url": "", "sequence": { "sequence": "MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGDGSTAGES", "length": 297, "header": "sp|O75344-3|FKBP6_HUMAN Isoform 3 of Inactive peptidyl-prolyl cis-trans isomerase FKBP6 OS=Homo sapiens OX=9606 GN=FKBP6 PE=1 SV=1 CANONICAL=O75344-1" }, "locus": { "chromosome": "7", "start_pos": 73342894, "end_pos": 73328429, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000413573.6", "url": "https://www.ensembl.org/id/ENST00000413573.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000394952.2", "url": "https://www.ensembl.org/id/ENSP00000394952.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Ward IM, Chen J", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "11673449", "url": "https://glygen.org/publication/PubMed/11673449" } ] }, { "title": "Cohesin component dynamics during meiotic prophase I in mammalian oocytes.", "journal": "Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology", "date": "2004", "authors": "Prieto I, Tease C, Pezzi N, Buesa JM, Ortega S, Kremer L, Martinez A, Martinez-A C, Hulten MA, Barbero JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "15125634", "url": "https://glygen.org/publication/PubMed/15125634" } ] }, { "title": "Female-specific features of recombinational double-stranded DNA repair in relation to synapsis and telomere dynamics in human oocytes.", "journal": "Chromosoma", "date": "2004", "authors": "Roig I, Liebe B, Egozcue J, Cabero L, Garcia M, Scherthan H", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "15235794", "url": "https://glygen.org/publication/PubMed/15235794" } ] }, { "title": "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6.", "journal": "Clin. Dysmorphol.", "date": "2005", "authors": "Metcalfe K, Simeonov E, Beckett W, Donnai D, Tassabehji M", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "reference": [ { "type": "PubMed", "id": "15770126", "url": "https://glygen.org/publication/PubMed/15770126" } ] }, { "title": "Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia.", "journal": "Mol. Hum. Reprod.", "date": "2005", "authors": "Westerveld G H, Repping S, Lombardi M P, van der Veen F", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "reference": [ { "type": "PubMed", "id": "16227348", "url": "https://glygen.org/publication/PubMed/16227348" } ] }, { "title": "Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men.", "journal": "Reproduction", "date": "2007", "authors": "Zhang Wei, Zhang Sizhong, Xiao Cuiying, Yang Yuan, Zhoucun A", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "reference": [ { "type": "PubMed", "id": "17307919", "url": "https://glygen.org/publication/PubMed/17307919" } ] }, { "title": "FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes.", "journal": "Biochemistry", "date": "2008", "authors": "Jarczowski Franziska, Fischer Gunter, Edlich Frank", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "reference": [ { "type": "PubMed", "id": "18529014", "url": "https://glygen.org/publication/PubMed/18529014" } ] }, { "title": "A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice.", "journal": "Molecular cell", "date": "2008", "authors": "Aravin AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, Toth KF, Bestor T, Hannon GJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "18922463", "url": "https://glygen.org/publication/PubMed/18922463" } ] }, { "title": "FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.", "journal": "J. Biol. Chem.", "date": "2009", "authors": "Jarczowski F, Jahreis G, Erdmann F, Schierhorn A, Fischer G, Edlich F", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "reference": [ { "type": "PubMed", "id": "19001379", "url": "https://glygen.org/publication/PubMed/19001379" } ] }, { "title": "ATR, BRCA1 and gammaH2AX localize to unsynapsed chromosomes at the pachytene stage in human oocytes.", "journal": "Reproductive biomedicine online", "date": "2009", "authors": "Garcia-Cruz R, Roig I, Robles P, Scherthan H, Garcia Caldes M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "19146767", "url": "https://glygen.org/publication/PubMed/19146767" } ] }, { "title": "Dynamics of cohesin proteins REC8, STAG3, SMC1 beta and SMC3 are consistent with a role in sister chromatid cohesion during meiosis in human oocytes.", "journal": "Human reproduction (Oxford, England)", "date": "2010", "authors": "Garcia-Cruz R, Brieno MA, Roig I, Grossmann M, Velilla E, Pujol A, Cabero L, Pessarrodona A, Barbero JL, Garcia Caldes M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "20634189", "url": "https://glygen.org/publication/PubMed/20634189" } ] }, { "title": "Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain.", "journal": "Proteins", "date": "2011", "authors": "Zeng L, Zhang Q, Yan K, Zhou MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "21465557", "url": "https://glygen.org/publication/PubMed/21465557" } ] }, { "title": "proTRAC--a software for probabilistic piRNA cluster detection, visualization and analysis.", "journal": "BMC bioinformatics", "date": "2012", "authors": "Rosenkranz D, Zischler H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "22233380", "url": "https://glygen.org/publication/PubMed/22233380" } ] }, { "title": "Selective constraint on copy number variation in human piwi-interacting RNA Loci.", "journal": "PloS one", "date": "2012", "authors": "Gould DW, Lukic S, Chen KC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "23056369", "url": "https://glygen.org/publication/PubMed/23056369" } ] }, { "title": "MicroRNA and piRNA profiles in normal human testis detected by next generation sequencing.", "journal": "PloS one", "date": "2013", "authors": "Yang Q, Hua J, Wang L, Xu B, Zhang H, Ye N, Zhang Z, Yu D, Cooke HJ, Zhang Y, Shi Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "23826142", "url": "https://glygen.org/publication/PubMed/23826142" } ] }, { "title": "PIWI-interacting RNAs (piRNAs) - a mouse testis perspective.", "journal": "Biochemistry. Biokhimiia", "date": "2013", "authors": "Bortvin A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "23980886", "url": "https://glygen.org/publication/PubMed/23980886" } ] }, { "title": "piClust: a density based piRNA clustering algorithm.", "journal": "Computational biology and chemistry", "date": "2014", "authors": "Jung I, Park JC, Kim S", "evidence": [ { "database": "Reactome", "id": "R-HSA-5601884", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884" } ], "reference": [ { "type": "PubMed", "id": "24656595", "url": "https://glygen.org/publication/PubMed/24656595" } ] }, { "title": "The piRNA-pathway factor FKBP6 is essential for spermatogenesis but dispensable for control of meiotic LINE-1 expression in humans.", "journal": "American journal of human genetics", "date": "2022-10-06", "authors": "Wyrwoll Margot J, Gaasbeek Channah M, Golubickaite Ieva, Stakaitis Rytis, Oud Manon S, Nagirnaja Liina, Dion Camille, Sindi Emad B, Leitch Harry G, Jayasena Channa N, Sironen Anu, Dicke Ann-Kristin, Rotte Nadja, Stallmeyer Birgit, Kliesch Sabine, Grangeiro Carlos H P, Araujo Tha\u00eds F, Lasko Paul, , D'Hauwers Kathleen, Smits Roos M, Ramos Liliana, Xavier Miguel J, Conrad Don F, Almstrup Kristian, Veltman Joris A, T\u00fcttelmann Frank, van der Heijden Godfried W", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" }, { "database": "RefSeq", "id": "NP_001128683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128683" } ], "reference": [ { "type": "PubMed", "id": "36150389", "url": "https://glygen.org/publication/PubMed/36150389" } ] }, { "title": "Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing.", "journal": "The Journal of cell biology", "date": "1996", "authors": "Scherthan H, Weich S, Schwegler H, Heyting C, Harle M, Cremer T", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "8794855", "url": "https://glygen.org/publication/PubMed/8794855" } ] }, { "title": "Association of BRCA1 with Rad51 in mitotic and meiotic cells.", "journal": "Cell", "date": "1997", "authors": "Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "9008167", "url": "https://glygen.org/publication/PubMed/9008167" } ] }, { "title": "Protein-protein interactions in the synaptonemal complex.", "journal": "Molecular biology of the cell", "date": "1997", "authors": "Tarsounas M, Pearlman RE, Gasser PJ, Park MS, Moens PB", "evidence": [ { "database": "Reactome", "id": "R-HSA-1221632", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632" } ], "reference": [ { "type": "PubMed", "id": "9285814", "url": "https://glygen.org/publication/PubMed/9285814" } ] }, { "title": "A novel human gene FKBP6 is deleted in Williams syndrome.", "journal": "Genomics", "date": "1998", "authors": "Meng X, Lu X, Morris CA, Keating MT", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "reference": [ { "type": "PubMed", "id": "9782077", "url": "https://glygen.org/publication/PubMed/9782077" } ] } ], "pathway": [ { "id": "hsa:8468", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8468", "resource": "KEGG Pathway" }, { "id": "R-HSA-1221632", "name": "Meiotic synapsis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1221632", "resource": "Reactome", "description": "Meiotic synapsis" }, { "id": "R-HSA-5601884", "name": "PIWI-interacting RNA (piRNA) biogenesis", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5601884", "resource": "Reactome", "description": "PIWI-interacting RNA (piRNA) biogenesis" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZQF4-1", "protein_name": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6", "gene_name": "Fkbp6", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVFSRLRNGIPPSRDDCQSPYERLSQRMLDISGDRGVLKDIIREGAGDPVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPPLIPPNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLAICEEQHLVEPAELLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGSGSSVGGN", "length": 327 }, "evidence": [ { "id": "45925957", "url": "http://www.informatics.jax.org/homology/45925957", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q91XW8-1", "protein_name": "Inactive peptidyl-prolyl cis-trans isomerase FKBP6", "gene_name": "Fkbp6", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGGSTRDPGALEGAGILGQSPYERLSQRMLDISGDRGVLKDIIREGTGDTVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRKGELARFLFKPAYAYGTLGCPPLIPPNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLATCEEQHLVEPAVLLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYERARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGSRSSVGGN", "length": 327 }, "evidence": [ { "id": "45925957", "url": "http://www.informatics.jax.org/homology/45925957", "database": "MGI" }, { "id": "O75344", "url": "https://omabrowser.org/oma/group/O75344/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9W1I9-1", "protein_name": "Inactive peptidyl-prolyl cis-trans isomerase shutdown", "gene_name": "shu", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MEENFEPYTPQLLKNPLSYSDLVKKGVEFEVDNSQQNHARDLGLDSDSDSDYEDALDVDGEELRSPWTYSFDELRALMSEIDENIYKRITRTGHVDREAVPNKARVSVRYSGYWEGETAPFDSSLLRGSKFVFETGQGTVVEGLEVAVRSMRPYEQAEFIISYKLLFGELGCPPRIKPKADALFKVEVIDYSLIGDAKGIDAIPQEDRDKFCVVYPKAVDLHLHGKDSVKLGRYQSAATAFERAVSSLNYCRMANDEEERKQTELLTTLNQNLMIVYNKMNKPKRACIMMKALRHLTMGNPSCKALFQEGRALAALGEYNLARNAYLQAQAKQPANKEISDEIISMNKRISKYEEASRDIWARAFSLKNSKSDVRKTPAQLEKEAKEQDFNDKMEDLIRRFKNTSDQQVSFSRKSYSNAQFDATCKLAKEHNLKLTLSPIQEDVLTLSKPDVKFA", "length": 455 }, "evidence": [ { "id": "O75344", "url": "https://omabrowser.org/oma/group/O75344/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 4, "go_terms": [ { "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "identical protein 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "synaptonemal complex", "id": "GO:0000795", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000795", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "spermatogenesis", "id": "GO:0007283", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007283", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "protein folding", "id": "GO:0006457", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006457", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "regulatory ncRNA-mediated gene silencing", "id": "GO:0031047", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031047", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "piRNA processing", "id": "GO:0034587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034587", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "meiotic cell cycle", "id": "GO:0051321", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051321", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "positive regulation of viral genome replication", "id": "GO:0045070", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045070", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" }, { "name": "siRNA-mediated retrotransposon silencing by heterochromatin formation", "id": "GO:0141007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0141007", "evidence": [ { "database": "UniProtKB", "id": "O75344", "url": "https://www.uniprot.org/uniprot/O75344" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 130, "end_pos": 132, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8I6GKI8-1", "P24368-1", "Q9QVC8-1", 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] } ] }, { "uniprot_ac": "A0A8I6AFJ6", "gene_name": "ENSRNOG00000068575", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AFJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFJ6" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AFJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFJ6" } ] } ] }, { "uniprot_ac": "A0A8I6AIC0", "gene_name": "ENSRNOG00000066761", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AIC0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AIC0" } ] } ] }, { "uniprot_ac": 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"activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GGK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GGK9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GGK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GGK9" } ] } ] }, { "uniprot_ac": "A0A8I6GH88", "gene_name": "Fkbp2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GH88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GH88" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GH88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GH88" } ] } ] }, { "uniprot_ac": "A0A8I6GJ67", "gene_name": "Pin1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ67" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ67" } ] } ] }, { "uniprot_ac": "A0A8I6GKI8", "gene_name": "Pin4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GKI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GKI8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GKI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GKI8" } ] } ] }, { "uniprot_ac": "A2AR02", "gene_name": "Ppig", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A2AR02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AR02" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A2AR02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AR02" } ] } ] }, { "uniprot_ac": "A6K0V4", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A6K0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6K0V4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A6K0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6K0V4" } ] } ] }, { "uniprot_ac": "B0G119", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "B0G119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G119" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "B0G119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G119" } ] } ] }, { "uniprot_ac": "D3ZQF4", "gene_name": "Fkbp6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "D3ZQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "D3ZQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF4" } ] } ] }, { "uniprot_ac": "D4AEG3", "gene_name": "Ppil4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] } ] }, { "uniprot_ac": "F5H284", "gene_name": "PPIAL4D", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F5H284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F5H284" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F5H284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F5H284" } ] } ] }, { "uniprot_ac": "F7EYK0", "gene_name": "Fkbp5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F7EYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EYK0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F7EYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EYK0" } ] } ] }, { "uniprot_ac": "G3V6L9", "gene_name": "Fkbp3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3V6L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6L9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3V6L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6L9" } ] } ] }, { "uniprot_ac": "G3V7V5", "gene_name": "Fkbp11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3V7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7V5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3V7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7V5" } ] } ] }, { "uniprot_ac": "M0RCZ9", "gene_name": "Ppial4g", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCZ9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCZ9" } ] } ] }, { "uniprot_ac": "O00170", "gene_name": "AIP", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O00170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00170" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O00170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00170" } ] } ] }, { "uniprot_ac": "O35465", "gene_name": "Fkbp8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35465" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35465" } ] } ] }, { "uniprot_ac": "O43447", "gene_name": "PPIH", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O43447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43447" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O43447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43447" } ] } ] }, { "uniprot_ac": "O54998", "gene_name": "Fkbp7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O54998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54998" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O54998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54998" } ] } ] }, { "uniprot_ac": "O55035", "gene_name": "Ppig", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] } ] }, { "uniprot_ac": "O75344", "gene_name": "FKBP6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] } ] }, { "uniprot_ac": "O95302", "gene_name": "FKBP9", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] } ] }, { "uniprot_ac": "P0DN26", "gene_name": "PPIAL4F", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] } ] }, { "uniprot_ac": "P0DN37", "gene_name": "PPIAL4G", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] } ] }, { "uniprot_ac": "P10111", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] } ] }, { "uniprot_ac": "P14832", "gene_name": "CPR1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14832" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14832" } ] } ] }, { "uniprot_ac": "P15425", "gene_name": "ninaA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P15425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15425" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P15425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15425" } ] } ] }, { "uniprot_ac": "P17742", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P17742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17742" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P17742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17742" } ] } ] }, { "uniprot_ac": "P20081", "gene_name": "FPR1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P20081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20081" } ] } ] }, { "uniprot_ac": "P22696", "gene_name": "ESS1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P22696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22696" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P22696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22696" } ] } ] }, { "uniprot_ac": "P23284", "gene_name": "PPIB", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P23284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23284" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P23284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23284" } ] } ] }, { "uniprot_ac": "P23285", "gene_name": "CPR2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P23285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23285" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P23285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23285" } ] } ] }, { "uniprot_ac": "P24368", "gene_name": "Ppib", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P24368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24368" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P24368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24368" } ] } ] }, { "uniprot_ac": "P24369", "gene_name": "Ppib", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] } ] }, { "uniprot_ac": "P25007", "gene_name": "Cyp1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] } ] }, { "uniprot_ac": "P25334", "gene_name": "CPR4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25334" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25334" } ] } ] }, { "uniprot_ac": "P25719", "gene_name": "CPR3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25719" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25719" } ] } ] }, { "uniprot_ac": "P26883", "gene_name": "Fkbp1a", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] } ] }, { "uniprot_ac": "P26885", "gene_name": "FKBP2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] } ] }, { "uniprot_ac": "P29117", "gene_name": "Ppif", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] } ] }, { "uniprot_ac": "P30405", "gene_name": "PPIF", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] } ] }, { "uniprot_ac": "P30412", "gene_name": "Ppic", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30412" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30412" } ] } ] }, { "uniprot_ac": "P30414", "gene_name": "NKTR", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30414" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30414" } ] } ] }, { "uniprot_ac": "P30415", "gene_name": "Nktr", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30415" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30415" } ] } ] }, { "uniprot_ac": "P30416", "gene_name": "Fkbp4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30416" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30416" } ] } ] }, { "uniprot_ac": "P32472", "gene_name": "FPR2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P32472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32472" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P32472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32472" } ] } ] }, { "uniprot_ac": "P35176", "gene_name": "CPR5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P35176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35176" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P35176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35176" } ] } ] }, { "uniprot_ac": "P38911", "gene_name": "FPR3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P38911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38911" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P38911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38911" } ] } ] }, { "uniprot_ac": "P40454", "gene_name": "RRD1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] } ] }, { "uniprot_ac": "P45877", "gene_name": "PPIC", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] } ] }, { "uniprot_ac": "P45878", "gene_name": "Fkbp2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] } ] }, { "uniprot_ac": "P47103", "gene_name": "CPR7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] } ] }, { "uniprot_ac": "P48375", "gene_name": "Fkbp12", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] } ] }, { "uniprot_ac": "P53691", "gene_name": "CPR6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] } ] }, { "uniprot_ac": "P53728", "gene_name": "CPR8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] } ] }, { "uniprot_ac": "P54353", "gene_name": "dod", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P54353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54353" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P54353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54353" } ] } ] }, { "uniprot_ac": "P54397", "gene_name": "Fkbp39", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P54397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54397" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P54397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54397" } ] } ] }, { "uniprot_ac": "P58389", "gene_name": "Ptpa", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P58389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58389" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P58389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58389" } ] } ] }, { "uniprot_ac": "P59024", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P59024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59024" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P59024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59024" } ] } ] }, { "uniprot_ac": "P62937", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] } ] }, { "uniprot_ac": "P62942", "gene_name": "FKBP1A", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] } ] }, { "uniprot_ac": "P68106", "gene_name": "FKBP1B", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P68106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68106" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P68106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68106" } ] } ] }, { "uniprot_ac": "P97534", "gene_name": "Fkbp1b", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P97534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97534" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P97534", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97534" } ] } ] }, { "uniprot_ac": "Q00688", "gene_name": 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