{
"uniprot_canonical_ac": "O75116-1",
"uniprot_ac": "O75116",
"uniprot_id": "ROCK2_HUMAN",
"mass": {
"chemical_mass": 160900.0,
"monoisotopic_mass": 160900.0
},
"refseq": {
"ac": "NP_001308572",
"name": "rho-associated protein kinase 2 isoform 2",
"summary": "The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572"
},
"gene_names": [
{
"name": "ROCK2",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O75116",
"id": "O75116"
},
{
"name": "KIAA0619",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O75116",
"id": "O75116"
},
{
"name": "ROCK-II",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572",
"id": "NP_001308572"
},
{
"name": "ROCK2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572",
"id": "NP_001308572"
}
],
"protein_names": [
{
"name": "Rho-associated protein kinase 2",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O75116"
},
{
"name": "2.7.11.1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75116"
},
{
"name": "ROCK-II",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75116"
},
{
"name": "Rho kinase 2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75116"
},
{
"name": "Rho-associated, coiled-coil-containing protein kinase 2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75116"
},
{
"name": "Rho-associated, coiled-coil-containing protein kinase II",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75116"
},
{
"name": "p164 ROCK-2; rho-associated, coiled-coil-containing protein kinase II",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572",
"id": "NP_001308572"
},
{
"name": "p164 ROCK-2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O75116"
},
{
"name": "rho-associated protein kinase 2 isoform 2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572",
"id": "NP_001308572"
}
],
"function": [
{
"annotation": "Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001308572",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572"
},
{
"database": "PubMed",
"id": "36969192",
"url": "https://glygen.org/publication/PubMed/36969192"
}
]
},
{
"annotation": "Dickkopf-1 and ROCK2 upregulation and associated protein aggregation in pseudoexfoliation syndrome and glaucoma.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001308572",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572"
},
{
"database": "PubMed",
"id": "37217133",
"url": "https://glygen.org/publication/PubMed/37217133"
}
]
},
{
"annotation": "Negative pressure induces dedifferentiation of hepatocytes via RhoA/ROCK pathway.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001308572",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572"
},
{
"database": "PubMed",
"id": "37210870",
"url": "https://glygen.org/publication/PubMed/37210870"
}
]
},
{
"annotation": "Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116#function"
},
{
"database": "PubMed",
"id": "10579722",
"url": "https://glygen.org/publication/PubMed/10579722"
},
{
"database": "PubMed",
"id": "15699075",
"url": "https://glygen.org/publication/PubMed/15699075"
},
{
"database": "PubMed",
"id": "19997641",
"url": "https://glygen.org/publication/PubMed/19997641"
},
{
"database": "PubMed",
"id": "17015463",
"url": "https://glygen.org/publication/PubMed/17015463"
},
{
"database": "PubMed",
"id": "16574662",
"url": "https://glygen.org/publication/PubMed/16574662"
},
{
"database": "PubMed",
"id": "21084279",
"url": "https://glygen.org/publication/PubMed/21084279"
},
{
"database": "PubMed",
"id": "21147781",
"url": "https://glygen.org/publication/PubMed/21147781"
},
{
"database": "PubMed",
"id": "19131646",
"url": "https://glygen.org/publication/PubMed/19131646"
}
]
},
{
"annotation": "SUMOylation of Rho-associated protein kinase 2 induces goblet cell metaplasia in allergic airways. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001308572",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572"
},
{
"database": "PubMed",
"id": "37393345",
"url": "https://glygen.org/publication/PubMed/37393345"
}
]
},
{
"annotation": "TIPE2 ameliorates neuroinflammation and cognitive impairment in sepsis-associated encephalopathy through regulating RhoA/ROCK2-NF-kappaB signaling pathway.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001308572",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572"
},
{
"database": "PubMed",
"id": "37748665",
"url": "https://glygen.org/publication/PubMed/37748665"
}
]
},
{
"annotation": "The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001308572",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572"
}
]
}
],
"disease": [],
"snv": [
{
"evidence": [
{
"id": "rs930986389",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs930986389"
},
{
"id": "rs930986389",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs930986389#frequency_tab"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 1132,
"end_pos": 1132,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SSS->NSS).",
"chr_id": "2",
"chr_pos": "11197233",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S1132",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs771483620",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771483620"
},
{
"id": "rs771483620",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs771483620"
},
{
"id": "rs771483620",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs771483620#frequency_tab"
},
{
"id": "rs771483620",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs771483620"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 310,
"end_pos": 310,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KNS->NNS).",
"chr_id": "2",
"chr_pos": "11224399",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K310",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs189516597",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs189516597"
},
{
"id": "rs189516597",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs189516597"
},
{
"id": "rs189516597",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs189516597"
},
{
"id": "rs189516597",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs189516597#frequency_tab"
},
{
"id": "rs189516597",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs189516597"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 425,
"end_pos": 425,
"sequence_org": "S",
"sequence_mut": "F",
"comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->F).",
"chr_id": "2",
"chr_pos": "11219012",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "0.000399",
"site_lbl": "S425",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "O75116",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75116"
},
{
"id": "rs2230774",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2230774"
},
{
"id": "rs2230774",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs2230774"
},
{
"id": "rs2230774",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs2230774"
},
{
"id": "rs2230774",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs2230774#frequency_tab"
},
{
"id": "rs2230774",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs2230774"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 431,
"end_pos": 431,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "T",
"sequence_mut": "N",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (TDS->NDS).",
"chr_id": "2",
"chr_pos": "11218994",
"ref_nt": "G",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "T431",
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
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},
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{
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{
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{
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{
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{
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},
{
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},
{
"id": "MONDO:0005575",
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},
{
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{
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},
{
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},
{
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},
{
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{
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{
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{
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{
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],
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{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
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"name": "gastric neoplasm",
"description": ""
},
{
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"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
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"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
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"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
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},
"synonyms": [
{
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"resource": "Disease Ontology",
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},
{
"id": "DOID:11054",
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"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
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"resource": "Disease Ontology",
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"name": "head and neck cancer",
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},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
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},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
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"name": "head/neck neoplasm",
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},
{
"id": "DOID:11934",
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"url": "http://disease-ontology.org/term/DOID:11934",
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}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
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},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
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],
"disease": [
{
"disease_id": "DOID:1612",
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"name": "breast cancer",
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},
"synonyms": [
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"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
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},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
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"description": ""
},
{
"id": "DOID:1612",
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"url": "http://disease-ontology.org/term/DOID:1612",
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},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
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},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
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},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "down",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "O75116",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75116"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
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"id": "R-HSA-4420097",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-4420097",
"database": "Reactome",
"categories": [
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]
},
{
"id": "R-HSA-5627117",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5627117",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-8980692",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8980692",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013026",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013026",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013106",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013106",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013407",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013407",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9013422",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013422",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9679191",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9679191",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_001308572",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308572",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "17989",
"url": "https://www.rhea-db.org/rhea/17989",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "46608",
"url": "https://www.rhea-db.org/rhea/46608",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "A0A8V8TL82",
"url": "https://www.uniprot.org/uniprot/A0A8V8TL82",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8V8TL82-1",
"url": "https://www.uniprot.org/uniprot/A0A8V8TL82-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8V8TL90",
"url": "https://www.uniprot.org/uniprot/A0A8V8TL90",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "A0A8V8TL90-1",
"url": "https://www.uniprot.org/uniprot/A0A8V8TL90-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "C9JFJ0",
"url": "https://www.uniprot.org/uniprot/C9JFJ0",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "C9JFJ0-1",
"url": "https://www.uniprot.org/uniprot/C9JFJ0-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "D6REE7",
"url": "https://www.uniprot.org/uniprot/D6REE7",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "D6REE7-1",
"url": "https://www.uniprot.org/uniprot/D6REE7-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "E9PF63",
"url": "https://www.uniprot.org/uniprot/E9PF63",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "E9PF63-1",
"url": "https://www.uniprot.org/uniprot/E9PF63-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O75116-1",
"url": "https://www.uniprot.org/uniprot/O75116-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS",
"length": 1388,
"header": "sp|O75116-1|ROCK2_HUMAN Isoform 1 of Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4 CANONICAL=O75116-1"
},
"isoforms": [
{
"isoform_ac": "A0A8V8TL82-1",
"url": "",
"sequence": {
"sequence": "MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPVHITQSHTMESMSFTYQRSSTSLNIATKPSSSHTLLDSDSDSEEESLPYLPISSEPNESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS",
"length": 1445,
"header": "tr|A0A8V8TL82-1|ROCK2_HUMAN Computationally mapped isoform of Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=1 CANONICAL=O75116-1"
},
"locus": {
"chromosome": "2",
"start_pos": 11344136,
"end_pos": 11183440,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000697752.1",
"url": "https://www.ensembl.org/id/ENST00000697752.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000513431.1",
"url": "https://www.ensembl.org/id/ENSP00000513431.1"
}
]
}
},
{
"isoform_ac": "A0A8V8TL90-1",
"url": "",
"sequence": {
"sequence": "LDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPVHITQSHTMESMSFTYQRSSTSLNIATKPSSSHTLLDSDSDSEEESLPYLPISSEPNESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPRLLDLAFKDWDWSFDDVDGGGDDDDDVFDF",
"length": 911,
"header": "tr|A0A8V8TL90-1|A0A8V8TL90_HUMAN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=1 CANONICAL=O75116-1"
},
"locus": {
"chromosome": "2",
"start_pos": 11215086,
"end_pos": 11184682,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000697790.1",
"url": "https://www.ensembl.org/id/ENST00000697790.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000513442.1",
"url": "https://www.ensembl.org/id/ENSP00000513442.1"
}
]
}
},
{
"isoform_ac": "C9JFJ0-1",
"url": "",
"sequence": {
"sequence": "DGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQTGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELS",
"length": 242,
"header": "tr|C9JFJ0-1|C9JFJ0_HUMAN Computationally mapped isoform of Rho associated coiled-coil containing protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=2 CANONICAL=O75116-1"
},
"locus": {
"chromosome": "2",
"start_pos": 11287736,
"end_pos": 11221329,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000431087.2",
"url": "https://www.ensembl.org/id/ENST00000431087.2"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000395957.2",
"url": "https://www.ensembl.org/id/ENSP00000395957.2"
}
]
}
},
{
"isoform_ac": "D6REE7-1",
"url": "",
"sequence": {
"sequence": "MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEVC",
"length": 446,
"header": "tr|D6REE7-1|D6REE7_HUMAN Computationally mapped isoform of non-specific serine/threonine protein kinase OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=1 CANONICAL=O75116-1"
},
"locus": {
"chromosome": "2",
"start_pos": 11344136,
"end_pos": 11218449,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000261535.7",
"url": "https://www.ensembl.org/id/ENST00000261535.7"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000261535.3",
"url": "https://www.ensembl.org/id/ENSP00000261535.3"
}
]
}
},
{
"isoform_ac": "E9PF63-1",
"url": "",
"sequence": {
"sequence": "MVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS",
"length": 1145,
"header": "tr|E9PF63-1|ROCK2_HUMAN Computationally mapped isoform of Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=1 CANONICAL=O75116-1"
},
"locus": {
"chromosome": "2",
"start_pos": 11227392,
"end_pos": 11183440,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000401753.5",
"url": "https://www.ensembl.org/id/ENST00000401753.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000385509.1",
"url": "https://www.ensembl.org/id/ENSP00000385509.1"
}
]
}
},
{
"isoform_ac": "O75116-1",
"url": "",
"sequence": {
"sequence": "MSRPPPTGKMPGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGLDSSSIGSGPGDAEADDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEQEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISTAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS",
"length": 1388,
"header": "sp|O75116-1|ROCK2_HUMAN Isoform 1 of Rho-associated protein kinase 2 OS=Homo sapiens OX=9606 GN=ROCK2 PE=1 SV=4 CANONICAL=O75116-1"
},
"locus": {
"chromosome": "2",
"start_pos": 11344136,
"end_pos": 11183440,
"strand": "+",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000315872.11",
"url": "https://www.ensembl.org/id/ENST00000315872.11"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000317985.6",
"url": "https://www.ensembl.org/id/ENSP00000317985.6"
}
]
}
}
],
"glycosylation": [
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 1114,
"start_aa": "Ser",
"end_pos": 1114,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser1114",
"evidence": [
{
"id": "O75116",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75116"
},
{
"id": "23301498",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/23301498"
},
{
"id": "30379171",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/30379171"
},
{
"id": "38253038",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/38253038"
},
{
"id": "35254053",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/35254053"
}
]
},
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 423,
"start_aa": "Ser",
"end_pos": 423,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser423",
"evidence": [
{
"id": "O75116",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75116"
},
{
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"type": "PubMed",
"id": "9548756",
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}
]
},
{
"title": "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors.",
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{
"title": "Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1.",
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]
},
{
"title": "Citron rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein Citron.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Di Cunto F, Calautti E, Hsiao J, Ong L, Topley G, Turco E, Dotto GP",
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"type": "PubMed",
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]
},
{
"title": "The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.",
"journal": "Nature",
"date": "1998",
"authors": "Jiang Y, Ma W, Wan Y, Kozasa T, Hattori S, Huang XY",
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"id": "R-HSA-416482",
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},
{
"title": "Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2.",
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"date": "1998",
"authors": "Schuebel KE, Movilla N, Rosa JL, Bustelo XR",
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"id": "R-HSA-8980692",
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]
},
{
"title": "Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3.",
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"date": "1998",
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]
},
{
"title": "Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24.",
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"authors": "Takahashi N, Tuiki H, Saya H, Kaibuchi K",
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{
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"id": "O75116",
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]
}
],
"pathway": [
{
"id": "hsa:9475",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9475",
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{
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{
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},
{
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{
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"description": "Sema4D induced cell migration and growth-cone collapse"
},
{
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"description": "VEGFA-VEGFR2 Pathway"
},
{
"id": "R-HSA-5627117",
"name": "RHO GTPases Activate ROCKs",
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"description": "RHO GTPases Activate ROCKs"
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{
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},
{
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{
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{
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{
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}
],
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{
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"tax_id": 9823,
"organism": "Sus scrofa",
"sequence": {
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"length": 1388
},
"evidence": [
{
"id": "O75116",
"url": "https://omabrowser.org/oma/group/O75116/",
"database": "OMA"
}
],
"common_name": "Pig"
},
{
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"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
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"length": 1388
},
"evidence": [
{
"id": "45917693",
"url": "http://www.informatics.jax.org/homology/45917693",
"database": "MGI"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q62868-1",
"protein_name": "Rho-associated protein kinase 2",
"gene_name": "Rock2",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MSRPPPTGKMPGAPEAAAGDGAGAGRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKSASFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYFRENLLLSDSPPCRENDAIQTRKSEESQEIQKKLYALEEHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITFRKNVESTLRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRTESDTAARLRKTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRISGLEEDLKTGKTLLAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKTTKARLADKNKIYESIEEAKSEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRNLTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDTQEQLSKLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDAEPDDGFPESRLEGWLSLPVRNNTKKFGWVKKYVIVSSKKILFYDSEQDKEQSNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIFQILYANEGESKKEPEFPVEPVGEKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECSRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPKKPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPS",
"length": 1388
},
"evidence": [
{
"id": "45917693",
"url": "http://www.informatics.jax.org/homology/45917693",
"database": "MGI"
}
],
"common_name": "Rat"
}
],
"go_annotation": {
"categories": [
{
"name": "Molecular Function",
"total": 12,
"go_terms": [
{
"name": "protein kinase activity",
"id": "GO:0004672",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004672",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "ATP binding",
"id": "GO:0005524",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "metal ion binding",
"id": "GO:0046872",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "small GTPase binding",
"id": "GO:0031267",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031267",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "kinase activity",
"id": "GO:0016301",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "protein serine/threonine kinase activity",
"id": "GO:0004674",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004674",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "Rho-dependent protein serine/threonine kinase activity",
"id": "GO:0072518",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072518",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "RNA binding",
"id": "GO:0003723",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003723",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "structural molecule activity",
"id": "GO:0005198",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "tau protein binding",
"id": "GO:0048156",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048156",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "tau-protein kinase activity",
"id": "GO:0050321",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050321",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "protein serine kinase activity",
"id": "GO:0106310",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0106310",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
}
]
},
{
"name": "Cellular Component",
"total": 7,
"go_terms": [
{
"name": "cytoplasm",
"id": "GO:0005737",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "cytoskeleton",
"id": "GO:0005856",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "centrosome",
"id": "GO:0005813",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "plasma membrane",
"id": "GO:0005886",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "nucleus",
"id": "GO:0005634",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "cytoplasmic ribonucleoprotein granule",
"id": "GO:0036464",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036464",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 62,
"go_terms": [
{
"name": "Rho protein signal transduction",
"id": "GO:0007266",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "phosphorylation",
"id": "GO:0016310",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016310",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "smooth muscle contraction",
"id": "GO:0006939",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006939",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "regulation of actin cytoskeleton organization",
"id": "GO:0032956",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032956",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "rhythmic process",
"id": "GO:0048511",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048511",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "organelle organization",
"id": "GO:0006996",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006996",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of centrosome duplication",
"id": "GO:0010825",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010825",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of connective tissue growth factor production",
"id": "GO:0032723",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032723",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "regulation of focal adhesion assembly",
"id": "GO:0051893",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051893",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "response to transforming growth factor beta",
"id": "GO:0071559",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071559",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of protein localization to early endosome",
"id": "GO:1902966",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902966",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of connective tissue replacement",
"id": "GO:1905205",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905205",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "negative regulation of myosin-light-chain-phosphatase activity",
"id": "GO:0035509",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035509",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "regulation of establishment of endothelial barrier",
"id": "GO:1903140",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903140",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "negative regulation of bicellular tight junction assembly",
"id": "GO:1903347",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1903347",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of protein phosphorylation",
"id": "GO:0001934",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "response to ischemia",
"id": "GO:0002931",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002931",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "protein phosphorylation",
"id": "GO:0006468",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006468",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of gene expression",
"id": "GO:0010628",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "negative regulation of gene expression",
"id": "GO:0010629",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "regulation of cell adhesion",
"id": "GO:0030155",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030155",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of cell migration",
"id": "GO:0030335",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030335",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of MAPK cascade",
"id": "GO:0043410",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043410",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "cellular response to testosterone stimulus",
"id": "GO:0071394",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071394",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "protein localization to plasma membrane",
"id": "GO:0072659",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of amyloid-beta formation",
"id": "GO:1902004",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902004",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "regulation of cell motility",
"id": "GO:2000145",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000145",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of endothelial cell migration",
"id": "GO:0010595",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010595",
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{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "actin cytoskeleton organization",
"id": "GO:0030036",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "blood vessel diameter maintenance",
"id": "GO:0097746",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097746",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "positive regulation of stress fiber assembly",
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{
"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "actomyosin structure organization",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031032",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "embryonic morphogenesis",
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"database": "UniProtKB",
"id": "O75116",
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}
],
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},
{
"name": "negative regulation of angiogenesis",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "regulation of nervous system process",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "regulation of circadian rhythm",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "peptidyl-threonine phosphorylation",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "cortical actin cytoskeleton organization",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "mitotic cytokinesis",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000281",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "regulation of stress fiber assembly",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "epithelial to mesenchymal transition",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "peptidyl-serine phosphorylation",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "negative regulation of nitric oxide biosynthetic process",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "canonical NF-kappaB signal transduction",
"id": "GO:0007249",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "regulation of cellular response to hypoxia",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "positive regulation of cardiac muscle hypertrophy",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010613",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "regulation of keratinocyte differentiation",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045616",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "centrosome duplication",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051298",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "regulation of protein metabolic process",
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"database": "UniProtKB",
"id": "O75116",
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],
"pmid": ""
},
{
"name": "mRNA destabilization",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "regulation of cell junction assembly",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901888",
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"database": "UniProtKB",
"id": "O75116",
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],
"pmid": ""
},
{
"name": "positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process",
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "regulation of establishment of cell polarity",
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "aortic valve morphogenesis",
"id": "GO:0003180",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003180",
"evidence": [
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"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "modulation by host of viral process",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044788",
"evidence": [
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"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "positive regulation of fibroblast growth factor production",
"id": "GO:0090271",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090271",
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{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "response to angiotensin",
"id": "GO:1990776",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990776",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "negative regulation of biomineral tissue development",
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{
"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "regulation of angiotensin-activated signaling pathway",
"id": "GO:0110061",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110061",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
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}
],
"pmid": ""
},
{
"name": "negative regulation of protein localization to lysosome",
"id": "GO:0150033",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0150033",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "positive regulation of amyloid precursor protein catabolic process",
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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902993",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
},
{
"name": "cellular response to acetylcholine",
"id": "GO:1905145",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:1905145",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 1052,
"end_pos": 1054,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 1163,
"end_pos": 1165,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 1332,
"end_pos": 1334,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 1372,
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"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 791,
"end_pos": 793,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 975,
"end_pos": 977,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation by PTPN11 stimulates its RHOA binding activity.",
"evidence": [
{
"database": "UniProtKB",
"id": "O75116",
"url": "https://www.uniprot.org/uniprot/O75116"
},
{
"database": "PubMed",
"id": "18559669",
"url": "https://glygen.org/publication/PubMed/18559669"
},
{
"database": "PubMed",
"id": "20826462",
"url": "https://glygen.org/publication/PubMed/20826462"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "17989",
"name": "",
"equation": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
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"D3ZML2-1",
"O08875-1",
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],
"evidence": [
{
"id": "17989",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/17989"
}
]
},
{
"id": "46608",
"name": "",
"equation": "ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"B2DD29-1",
"D3ZML2-1",
"O08875-1",
"O35831-1",
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],
"evidence": [
{
"id": "46608",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/46608"
}
]
},
{
"id": "R-HSA-3928576",
"name": "RHOA:GTP binds ROCK, activating it",
"equation": "",
"summary": "EPHB receptor-induced phosphorylation of coffin is at least partially controlled by Rho-associated kinase (ROCK) and LIM domain kinase (LIMK) activities (Shi et al. 2009). ROCK structure comprises a kinase domain located at the amino terminus of the protein, a coiled-coil region containing the Rho-binding domain (RBD), and a pleckstrin-homology (PH) domain with a cysteine-rich domain (CRD). In resting cells ROCKs exist in an autoinhibition state where the kinase domain interacts with the C-terminal inhibitory region. Binding of active RHOA:GTP to RBD stimulates the phosphotransferase activity of ROCK by disrupting the interaction between the catalytic and the inhibitory C-terminal region of the enzyme (Khalil 2010).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O75116-1",
"P61586-1"
],
"evidence": [
{
"id": "R-HSA-3928576",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928576"
}
]
},
{
"id": "R-HSA-3928577",
"name": "ROCK phosphorylates LIMK1,2",
"equation": "",
"summary": "Rho-associated kinases (ROCKs) contribute to the formation of actin filaments by inactivating cofilin via phosphorylation of LIM domain kinases (LIMKs). ROCKs phosphorylate LIMK1 at Thr508 and LIMK2 at Thr505, enhancing the ability of LIMKs to phosphorylate cofilin. LIMK1 has been shown to be involved in dendritic spine development, as LIMK1 KO mice fail to form morphologically mature dendritic spines (Meng et al. 2002).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P53667-1",
"Q13464-1",
"O75116-1",
"P61586-1",
"P53671-1"
],
"evidence": [
{
"id": "R-HSA-3928577",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928577"
}
]
},
{
"id": "R-HSA-3928616",
"name": "Activated ROCK phosphorylates MRLCs",
"equation": "",
"summary": "The RHOA-ROCK-myosin pathway mediates neurite retraction by increasing the phosphorylation of the regulatory chain of myosin (Amano et al. 1998). Non-muscle myosin II (NMM2) is an actin-based motor protein that plays a crucial role in a variety of cellular processes, including cell migration, polarity formation, and cytokinesis. NMM2 consists of two myosin heavy chains encoded by MYH9, MYH10 or MYH14 (NMHC-IIA, B and C), two copies of MYL6 essential light chain protein, and two regulatory light chains (MRLCs), MYL9 and MYLC2B. Myosin II activity is stimulated by phosphorylation of MRLC. Diphosphorylation at Thr-19 and Ser-20 increases both actin-activated Mg2+ ATPase activity and the stability of myosin II filaments; monophosphorylation at Ser-20 is less effective. Kinases responsible for the phosphorylation include myosin light chain kinase (MLCK), ROCK kinase, citron kinase, myotonic dystrophy kinase-related CDC42-binding protein kinase, and Zipper-interacting protein (ZIP) kinase. ROCK activity has been shown to regulate MRLC phosphorylation directly by mono- (Amano et al. 1996) or di- (Ueda et al. 2002) phosphorylation of MRLC.",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O75116-1",
"P61586-1"
],
"evidence": [
{
"id": "R-HSA-3928616",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928616"
}
]
},
{
"id": "R-HSA-3928647",
"name": "RHOA:GTP:Mg2+ binds ROCK1,ROCK2",
"equation": "",
"summary": "RHOA propagates downstream signals by binding to effector proteins such as Rho-associated, coiled-coil containing protein kinases (ROCKs). ROCKs consist of an amino-terminal kinase domain, followed by a Rho-binding domain (RBD) and a carboxy terminal cysteine-rich domain (CRD) located within the pleckstrin homology (PH) motif. RHOA:GTP interacts with the RBD domain and activates the phosphotransferase activity (Ishizaki et al. 1996, Amano et al. 2000).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"P35968-1",
"O75116-1",
"P07900-1",
"P61586-1",
"Q05397-1"
],
"evidence": [
{
"id": "R-HSA-3928647",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3928647"
}
]
},
{
"id": "R-HSA-419049",
"name": "ROCK activation by RHO",
"equation": "",
"summary": "ROCKs are primarily known as downstream effectors of RHO, but they can also be activated by arachidonic acid, which binds to the pleckstrin homology domain, releasing an autoinhibitory loop within ROCK and allowing catalytic activity (Araki et al. 2001). Proteolytic cleavage at the C-terminus by caspase-3 and granzyme B also activates ROCK1 and ROCK2, causing plasma membrane blebbing during apoptosis (Coleman et al. 2001, Sebbagh et al. 2005). Multiple targets of ROCK contribute to the stabilization of actin filaments and the generation of actin-myosin contractile force.",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O75116-1",
"P61586-1"
],
"evidence": [
{
"id": "R-HSA-419049",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419049"
}
]
},
{
"id": "R-HSA-419083",
"name": "Myosin phosphatase inactivation by ROCK",
"equation": "",
"summary": "The activity of nonmuscle myosin II (NMM2) is suppressed by dephosphorylation of myosin regulatory light chains (MRLC), MYL9 and MYL12B, by the MLC phosphatase. The MLC phosphatase is composed of a catalytic subunit (PPP1CB) and two regulatory subunits, myosin phosphatase-targeting subunit 1 (MYPT1, PPP1R12A) and M20 (MYPT2, PPP1R12B). MYPT1 binds directly to myosin II. Myosin phosphatase is inhibited by ROCKs. ROCKs phosphorylate MYPT1 subunit of the myosin phosphatase at two inhibitory sites, Thr696 and Ser852, resulting in a decrease in MRLC phosphatase activity and an increase in phosphorylated MRLC (Kimura et al. 1996, Nakai et al. 1997, Katoh et al. 2001, Iwasaki et al. 2001), which promotes binding to filamentous actin and stress fibre formation. This effect is synergistic with the direct phosphorylation of MRLC by ROCKs.",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O75116-1",
"P62140-1",
"P61586-1"
],
"evidence": [
{
"id": "R-HSA-419083",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419083"
}
]
},
{
"id": "R-HSA-419087",
"name": "LIM kinase phosphorylation by ROCK",
"equation": "",
"summary": "LIM kinases are serine protein kinases with a unique combination of two N-terminal LIM motifs, a central PDZ domain, and a C-terminal protein kinase domain. ROCK1 and ROCK2 phosphorylate and activate LIM kinases LIMK1 and LIMK2 at Thr508 and Thr505, respectively (Ohashi et al. 2000, Sumi et al. 2001). These threonine residues lay within the activation loop of the kinase domain. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, resulting in stabilization of the actin cytoskeleton (Pandey et al. 2006).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P53667-1",
"Q13464-1",
"O75116-1",
"P61586-1",
"P53671-1"
],
"evidence": [
{
"id": "R-HSA-419087",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419087"
}
]
},
{
"id": "R-HSA-419197",
"name": "Myosin regulatory light chain phosphorylation by ROCK",
"equation": "",
"summary": "Nonmuscle myosin II (NMM2) is an actin-based motor protein that plays a crucial role in a variety of cellular processes, including smooth muscle contraction, cell migration, polarity formation, and cytokinesis. NMM2 consists of two myosin heavy chains encoded by MYH9, MYH10, MYH14 (NMHC-IIA, B and C) or MYH11, two copies of MYL6 essential light chain protein, and two regulatory light chains (MRLCs), MYL9 and MYL12B. Myosin II activity is stimulated by phosphorylation of MRLC. Diphosphorylation at Thr-19 and Ser-20 (commonly referred in the literature as Thr-18 and Ser-19) increases both actin-activated Mg2+ ATPase activity and the stability of myosin II filaments; monophosphorylation at Ser-20 is less effective (Ikebe and Hartshorne 1985, Ikebe et al. 1988). Kinases responsible for the phosphorylation include myosin light chain kinase (MLCK), ROCK kinase, citron kinase, myotonic dystrophy kinase-related CDC42-binding protein kinase, and Zipper-interacting protein (ZIP) kinase. ROCK activity has been shown to regulate MRLC phosphorylation by directly mono- or diphosphorylating MRLC (Amano et al., 1996, Ueda et al., 2002, Watanabe et al. 2007).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O75116-1",
"P61586-1"
],
"evidence": [
{
"id": "R-HSA-419197",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-419197"
}
]
},
{
"id": "R-HSA-5218826",
"name": "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732",
"equation": "",
"summary": "Activated ROCK directly phosphorylates FAK1 on S732. This phosphorylation induces a conformational change that is necessary to trigger the phosphorylation of FAK on Y407 (Le Bouef et al. 2006).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"P35968-1",
"O75116-1",
"P07900-1",
"P61586-1",
"Q05397-1"
],
"evidence": [
{
"id": "R-HSA-5218826",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5218826"
}
]
},
{
"id": "R-HSA-5228992",
"name": "ROCK1,ROCK2 are activated",
"equation": "",
"summary": "RHOA propagates downstream signals by binding to effector proteins such as Rho-associated, coiled-coil containing protein kinases (ROCKs). ROCKs consist of an amino-terminal kinase domain, followed by a Rho-binding domain (RBD) and a carboxy terminal cysteine-rich domain (CRD) located within the pleckstrin homology (PH) motif. RHOA:GTP interacts with the RBD domain and activates the phosphotransferase activity (Ishizaki et al. 1996, Amano et al. 2000).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O75116-1",
"P61586-1"
],
"evidence": [
{
"id": "R-HSA-5228992",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5228992"
}
]
},
{
"id": "R-HSA-9013009",
"name": "RHOA binds effectors at the plasma membrane",
"equation": "",
"summary": "In its GTP bound active form, plasma membrane associated RHOA (or constitutively active RHOA mutant in the high throughput study by Bagci et al. 2020) binds to the following effectors:
ANLN (Piekny and Glotzer 2008; Budnar et al. 2019; Bagci et al. 2020)
CIT (Madaule et al. 1995; Bagci et al. 2020) and its neuron specific splicing isoform CIT 3 (Di Cunto et al. 1998)
DAAM1 (Aspenstrom et al. 2006; Higashi et al. 2008)
DIAPH1 (Otomo et al. 2005; Higashi et al. 2008; Lammers et al. 2008; Gao et al. 2009; Li and Sewer 2010; Bagci et al. 2020)
DIAPH3 (Alberts et al. 1998; Watanabe et al. 2010; Staus et al. 2011; Chen et al. 2017; Bagci et al. 2020)
IQGAP1 (Casteel et al. 2012)
PKN1 (Maesaki et al. 1999; Hutchinson et al. 2011; Hutchinson et al. 2013)
PKN2 (Hutchinson et al. 2013; Bagci et al. 2020)
PKN3 (Hutchinson et al. 2013)
PLD1 (Hammond et al. 1997; Yamazaki et al. 1999)
RHPN1 (Watanabe et al. 1996; Peck et al. 2002)
RHPN2 (Peck et al. 2002)
ROCK1 (Ishizaki et al. 1996; Leung et al. 1996; Bagci et al. 2020)
ROCK2 (Leung et al. 1996; Bagci et al. 2020)
RTKN (Reid et al. 1996; Fu et al. 2000)
SLK (Bagci et al. 2020: interaction and activation of SLK downstream of RHOA confirmed in detail)
STK10 (Bagci et al. 2020: interaction corroborated by additional experimental methods)
The following putative RHOA effectors are annotated as candidates either because of opposing findings reported by different studies or because their binding to RHOA was only shown in the context of constitutively active RHOA mutant in the high throughput screen by Bagci et al. 2020:
AAAS (Bagci et al. 2020)
ABCD3 (Bagci et al. 2020)
ACBD5 (Bagci et al. 2020)
ACTC1 (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
C1QBP (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CAVIN1 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
FAF2 (Bagci et al. 2020)
FLOT1 (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
FMNL3 (Bagci et al. 2020: binding to RHOA; Vega et al. 2011: no binding to RHOA)
HMOX2 (Bagci et al. 2020)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
PCDH7 (Bagci et al. 2020)
SCFD1 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TJP2 (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
RHOA does not bind the following effectors:
CCDC187 (Bagci et al. 2020)
CDC42BPA (Leung et al. 1998)
CDC42BPB (Leung et al. 1998)
CDC42EP1 (Joberty et al. 1999)
CDC42EP2 (Joberty et al. 1999)
CDC42EP3 (Joberty et al. 1999)
CDC42EP4 (Joberty et al. 1999)
CDC42EP5 (Joberty et al. 1999)
FMNL2 (Kitzing et al. 2010)
IQGAP2 (Brill et al. 1996)
KIAA0355 (Bagci et al. 2020)
PLD2 (Kodaki and Yamashita 1997)
WAS (WASP) (Aspenstrom et al. 1996)",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13393-1",
"Q13464-1",
"O14578-1",
"O75116-1",
"P28288-1",
"P68032-1",
"Q16512-1",
"P61586-1",
"Q6P5Z2-1",
"Q9H2G2-1",
"P30519-1",
"Q16513-1",
"O94804-1"
],
"evidence": [
{
"id": "R-HSA-9013009",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013009"
}
]
},
{
"id": "R-HSA-9013024",
"name": "RHOB binds effectors at the plasma membrane",
"equation": "",
"summary": "In its GTP bound active form, plasma membrane associated RHOB (or constitutively active RHOB mutant in the high throughput study by Bagci et al. 2020) binds to the following effectors at the plasma membrane:
CIT (Madaule et al. 1995; Bagci et al. 2020) and its neuron specific isoform CIT 3 (Di Cunto et al. 1998)
DAAM1 (Higashi et al. 2008)
PKN1 (Hutchinson et al. 2013)
PKN2 (Hutchinson et al. 2013; Bagci et al. 2020)
PKN3 (Hutchinson et al. 2013)
ROCK1 (Leung et al. 1996; Bagci et al. 2020)
ROCK2 (Leung et al. 1996; Bagci et al. 2020)
RTKN (Reid et al. 1996)
The following putative RHOB effectors were identified only in the high throughput study by Bagci et al. 2020, where they were shown to bind to the active mutant of RHOB, and are annotated as candidate RHOB effectors:
ACTC1 (Bagci et al. 2020)
ANLN (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CAVIN1 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
FLOT1 (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
PCDH7 (Bagci et al. 2020)
SLK (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
STK10 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TJP2 (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
Active RHOB does not bind the following effectors:
AAAS (Bagci et al. 2020)
ABCD3 (Bagci et al. 2020)
ACBD5 (Bagci et al. 2020)
ATP6AP1 (Bagci et al. 2020)
BCAP31 (Bagci et al. 2020)
C1QBP (Bagci et al. 2020)
CCDC115 (Bagci et al. 2020)
CCDC187 (Bagci et al. 2020)
DDRGK1 (Bagci et al. 2020)
EMC3 (Bagci et al. 2020)
FAF2 (Bagci et al. 2020)
FMNL2 (Kitzing et al. 2010)
FMNL3 (Bagci et al. 2020)
HMOX2 (Bagci et al. 2020)
IQGAP1 (Casteel et al. 2012)
KIAA0355 (Bagci et al. 2020)
LBR (Bagci et al. 2020)
MACO1 (Bagci et al. 2020)
LMAN1 (Bagci et al. 2020)
PGRMC2 (Bagci et al. 2020)
RHOA (Bagci et al. 2020)
SCFD1 (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STX5 (Bagci et al. 2020)
TEX2 (Bagci et al. 2020)
TMEM87A (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAPB (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O14578-1",
"O75116-1",
"P68032-1",
"Q16512-1",
"P11274-1",
"Q6P5Z2-1",
"Q9H2G2-1",
"Q16513-1",
"O94804-1"
],
"evidence": [
{
"id": "R-HSA-9013024",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013024"
}
]
},
{
"id": "R-HSA-9013110",
"name": "RHOC binds effectors at the plasma membrane",
"equation": "",
"summary": "In its GTP bound active form, plasma membrane associated RHOC binds to the following cytosolic and plasma membrane effectors:
CIT (Madaule et al. 1995; Bagci et al. 2020) and its neuron specific isoform CIT 3 (Di Cunto et al. 1998)
DAAM1 (Higashi et al. 2008)
DIAPH1 (Higashi et al. 2008)
FMNL2 (Kitzing et al. 2010, Moriya et al. 2012)
IQGAP1 (Casteel et al. 2012)
PKN1 (Hutchinson et al. 2013)
PKN2 (Hutchinson et al. 2013, Bagci et al. 2020)
PKN3 (Hutchinson et al. 2013)
ROCK1 (Leung et al. 1996, Bagci et al. 2020)
ROCK2 (Leung et al. 1996, Bagci et al. 2020)
RTKN (Reid et al. 1996)
Opposing findings have been reported on the following putative RHOC effectors, or they were identified only in the high throughput study by Bagci et al. 2020, where they were shown to bind to the active mutant of RHOC; they are therefore annotated as candidate RHOC effectors:
ABCD3 (Bagci et al. 2020)
ACBD5 (Bagci et al. 2020)
ANLN (Bagci et al. 2020)
ARHGAP1 (Bagci et al. 2020)
BCR (Bagci et al. 2020)
C1QBP (Bagci et al. 2020)
CAV1 (Bagci et al. 2020)
CAVIN1 (Bagci et al. 2020)
CCDC187 (Bagci et al. 2020)
DEPDC1B (Bagci et al. 2020)
DIAPH3 (Bagci et al. 2020)
ERBIN (Bagci et al. 2020)
FLOT1 (Bagci et al. 2020)
FLOT2 (Bagci et al. 2020)
FMNL3 (Vega et al. 2011: binds to activated RHOC; Bagci et al. 2020: does not bind to active RHOC)
IQGAP3 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
MCAM (Bagci et al. 2020)
MYO9B (Bagci et al. 2020)
RHOA (Bagci et al. 2020)
SLK (Bagci et al. 2020)
STBD1 (Bagci et al. 2020)
STK10 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TJP2 (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMPO (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
Active RHOC does not bind to
AAAS (Bagci et al. 2020)
ACTC1 (Bagci et al. 2020)
ATP6AP1 (Bagci et al. 2020)
BCAP31 (Bagci et al. 2020)
CCDC115 (Bagci et al. 2020)
DDRGK1 (Bagci et al. 2020)
EMC3 (Bagci et al. 2020)
FAF2 (Bagci et al. 2020)
HMOX2 (Bagci et al. 2020)
KIAA0355 (Bagci et al. 2020)
PCDH7 (Bagci et al. 2020)
SCFD1 (Bagci et al. 2020)
SNAP23 (Bagci et al. 2020)
SOWAHC (Bagci et al. 2020)
TEX2 (Bagci et al. 2020)
TMEM87A (Bagci et al. 2020)
FMNL3 (Bagci et al. 2020)
YKT6 (Bagci et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O14578-1",
"O75116-1",
"P28288-1",
"Q16512-1",
"P61586-1",
"P11274-1",
"Q6P5Z2-1",
"Q9H2G2-1",
"Q16513-1",
"O94804-1"
],
"evidence": [
{
"id": "R-HSA-9013110",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013110"
}
]
},
{
"id": "R-HSA-9018758",
"name": "RHOH binds effectors at the plasma membrane",
"equation": "",
"summary": "RHOH plays an important role in development of T lymphocytes and binds to several kinases involved in T lymphocyte activation, including:
ZAP70 (Gu et al. 2006, Chae et al. 2010, Wang et al. 2011)
LCK (Chae et al. 2010, Wang et al. 2011)
CSK (Wang et al. 2010).
Additional RHOH interactors include:
PAK1 (Wang et al. 2010; Tajadura Ortega et al. 2018)
PAK2 (Tajadura Ortega et al. 2018)
PAK4 (Tajadura Ortega et al. 2018)
PAK5 (Wu and Frost 2006; Tajadura Ortega et al. 2018)
PAK6 (Tajadura Ortega et al. 2018)
The following RHOH interactors have only been reported in a high throughput screen by Bagci et al. 2020, and are therefore annotated as candidate RHOH effectors:
CAV1 (Bagci et al. 2020).
DBN1 (Bagci et al. 2020)
DBT (Bagci et al. 2020)
FAM91A1 (Bagci et al. 2020)
JUP (Bagci et al. 2020)
LAMTOR1 (Bagci et al. 2020)
MTR (Bagci et al. 2020)
NIPSNAP2 (Bagci et al. 2020)
NSFL1C (Bagci et al. 2020)
OSBPL11 (Bagci et al. 2020)
RAB7A (Bagci et al. 2020)
RALGAPA1 (Bagci et al. 2020)
ROCK1 (Bagci et al. 2020)
ROCK2 (Bagci et al. 2020)
SLC1A5 (Bagci et al. 2020)
SLC4A7 (Bagci et al. 2020)
STOM (Bagci et al. 2020)
TFRC (Bagci et al. 2020)
TMEM59 (Bagci et al. 2020)
TUBA1B (Bagci et al. 2020)
UACA (Bagci et al. 2020)
VAMP3 (Bagci et al. 2020)
VANGL1 (Bagci et al. 2020)
VCP (Bagci et al. 2020)
WDR11 (Bagci et al. 2020)",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"P41240-1",
"Q99707-1",
"P11182-1",
"O75116-1",
"P55072-1",
"P06239-1",
"Q13153-1",
"Q13177-1",
"P68363-1",
"Q9P286-1",
"P43403-1",
"O96013-1",
"Q9NQU5-1",
"P51149-1"
],
"evidence": [
{
"id": "R-HSA-9018758",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018758"
}
]
},
{
"id": "R-HSA-9018778",
"name": "RHOBTB1 binds interacting proteins at the endosome membrane",
"equation": "",
"summary": "RHOBTB1, like the other member of the RHOBTB family, RHOBTB2, as well as the divergent RHOBTB3, which does not belong to the RHO superfamily, binds to CUL3 (cullin-3), a core component of the BTB-CUL3-RBX2 E3 ubiquitin ligase complex (Berthold et al. 2008). RHOBTB1 binds to ROCK1 and ROCK2, and ROCK-mediated phosphorylation of RHOBTB1 may regulate its association with CUL3 (Haga et al. 2019). RHOBTB1 has been proposed as a substrate adaptor for PDE5, targeting it to CUL3 complexes for ubiquitination (Mukohda et al. 2019).
Candidate RHOBTB1 interactors identified in the screen conducted by Bagci et al. 2020 include:
CCT2 (Bagci et al. 2020)
CCT7 (Bagci et al. 2020)
COPS2 (Bagci et al. 2020)
COPS4 (Bagci et al. 2020)
CPSF7 (Bagci et al. 2020)
DBN1 (Bagci et al. 2020)
GPS1 (Bagci et al. 2020)
HNRNPC (Bagci et al. 2020)
MYO6 (Bagci et al. 2020)
RBBP6 (Bagci et al. 2020)
RBMX (Bagci et al. 2020)
RNF20 (Bagci et al. 2020)
SPEN (Bagci et al. 2020)
SRRM1 (Bagci et al. 2020)
STK38 (Bagci et al. 2020)
TRA2B (Bagci et al. 2020)
TXNL1 (Bagci et al. 2020)
VIM (Bagci et al. 2020)
Some of the candidate interactors, like CCT2 and CCT7, are part of the CCT chaperone complex, while others (DBN1 and MYO6) are related to the actin cytoskeleton, RNA splicing and export (HNRNPC, RBMX and SRRM1) or COP9 signalosome (COPS2 and COPS4).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O76074-1",
"O75116-1",
"Q5VTR2-1",
"Q15208-1",
"Q7Z6E9-1"
],
"evidence": [
{
"id": "R-HSA-9018778",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9018778"
}
]
},
{
"id": "R-HSA-9680443",
"name": "ROCK1,2 bind ROCKi",
"equation": "",
"summary": "Ripasudil (Glanatec), as its hydrochloride hydrate (K-115), is a specifc Rho-associated coiled-coil containing protein kinase (ROCK) inhibitor (ROCKi) used for the treatment of glaucoma and ocular hypertension in Japan (Garnock-Jones 2014). Netarsudil is a USA-approved ROCKi used to treat glaucoma and ocular hypertenstion (Sturdivant et al. 2016, Tanna & Johnson 2018).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13464-1",
"O75116-1"
],
"evidence": [
{
"id": "R-HSA-9680443",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680443"
}
]
}
],
"reaction_participants": [],
"reaction_enzymes": [
{
"uniprot_ac": "A0A087WRH8",
"gene_name": "Gm5157",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A087WRH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WRH8"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
"id": "A0A087WRH8",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WRH8"
}
]
}
]
},
{
"uniprot_ac": "A0A087WSA6",
"gene_name": "Gm7358",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "A0A087WSA6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/A0A087WSA6"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "",
"evidence": [
{
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{
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},
{
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}
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}
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},
{
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"ec_number": "2.7.11.1",
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},
{
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}
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}
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"ec_number": "2.7.11.1",
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]
},
{
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}
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}
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}
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},
{
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}
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"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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},
{
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}
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}
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}
]
},
{
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}
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}
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},
{
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}
]
}
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},
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"ec_number": "2.7.11.1",
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}
]
},
{
"ec_number": "2.7.11.31",
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"id": "Q13131",
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]
},
{
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},
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}
]
},
{
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"id": "Q13131",
"database": "UniProtKB",
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]
}
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"ec_number": "2.7.11.1",
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}
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},
{
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}
]
}
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}
]
},
{
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}
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},
{
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}
]
}
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},
{
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]
}
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}
]
},
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{
"ec_number": "2.3.2.27",
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},
{
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]
},
{
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]
}
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"ec_number": "2.7.11.12",
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]
},
{
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}
]
}
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]
},
{
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]
}
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},
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{
"ec_number": "3.1.4.4",
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]
},
{
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]
}
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"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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]
},
{
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}
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"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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]
},
{
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}
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},
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{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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},
{
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}
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{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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]
},
{
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}
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"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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},
{
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}
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},
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}
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},
{
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}
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},
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}
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]
},
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]
},
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]
},
{
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]
}
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"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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]
},
{
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"id": "Q13976",
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]
}
]
},
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{
"ec_number": "2.7.11.22",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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]
},
{
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{
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]
},
{
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]
},
{
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]
}
]
},
{
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{
"ec_number": "2.7.11.17",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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{
"id": "Q14012",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14012"
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]
},
{
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{
"id": "Q14012",
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]
}
]
},
{
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{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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"id": "Q14296",
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"url": "https://www.uniprot.org/uniprot/Q14296"
}
]
},
{
"ec_number": "2.7.11.8",
"activity": "ATP + L-threonyl-[Fas-activated protein] = ADP + H(+) + O-phospho-L-threonyl-[Fas-activated protein].",
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{
"id": "Q14296",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q14296"
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]
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{
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{
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},
{
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}
]
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{
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]
}
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{
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}
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},
{
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}
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}
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},
{
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}
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}
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},
{
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}
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{
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},
{
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}
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},
{
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}
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},
{
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}
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]
},
{
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{
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]
},
{
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}
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{
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{
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{
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]
},
{
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]
},
{
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]
}
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{
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]
},
{
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},
{
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]
}
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{
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{
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}
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{
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{
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]
},
{
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}
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]
},
{
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}
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{
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]
},
{
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}
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{
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]
},
{
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]
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},
{
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{
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]
},
{
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]
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]
},
{
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}
]
}
]
},
{
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{
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]
},
{
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]
}
]
},
{
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]
},
{
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]
}
]
},
{
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{
"ec_number": "2.7.11.1",
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]
},
{
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{
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}
]
}
]
},
{
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{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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]
},
{
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{
"id": "Q5VST9",
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]
}
]
},
{
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{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
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]
},
{
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]
}
]
},
{
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{
"ec_number": "2.3.2.27",
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{
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{
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