{ "uniprot_canonical_ac": "O75094-1", "uniprot_ac": "O75094", "uniprot_id": "SLIT3_HUMAN", "mass": { "chemical_mass": 167713.0, "monoisotopic_mass": 167713.0 }, "refseq": { "ac": "NP_001258875", "name": "slit homolog 3 protein isoform 1 precursor", "summary": "The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. 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Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" }, { "database": "PubMed", "id": "36793891", "url": "https://glygen.org/publication/PubMed/36793891" } ] }, { "annotation": "Isolated congenital diaphragm hernia associated with homozygous SLIT3 gene variant in dizygous twins.", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" }, { "database": "PubMed", "id": "33933663", "url": "https://glygen.org/publication/PubMed/33933663" } ] }, { "annotation": "LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis.", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" }, { "database": "PubMed", "id": "36017912", "url": "https://glygen.org/publication/PubMed/36017912" } ] }, { "annotation": "LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis.", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" }, { "database": "PubMed", "id": "35034539", "url": "https://glygen.org/publication/PubMed/35034539" } ] }, { "annotation": "May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094#function" } ] }, { "annotation": "Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women.", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" }, { "database": "PubMed", "id": "32762475", "url": "https://glygen.org/publication/PubMed/32762475" } ] }, { "annotation": "The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O75094", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75094" } ], "glycoeffect": [ "n-glyco-sequon-loss", "n-glyco-sequon-gain" ], "start_pos": 192, "end_pos": 192, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "S", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NIS->SIS); n-glyco-sequon-gain (NNN->NNS).", "chr_id": "5", "chr_pos": "168823314", "ref_nt": "T", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N192", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O75094", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75094" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O75094", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75094" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid neoplasm", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Kidney cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:263", "evidence": [ { "database": "BioXpress", "id": "O75094", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75094" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O75094", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75094" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "common_name": "Human" } ], "gene": [ { "name": "SLIT3", "url": "https://www.uniprot.org/uniprot/O75094", "locus": { "chromosome": "5", "start_pos": 168661740, "end_pos": 169301139, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000184347", "url": "https://www.ensembl.org/id/ENSG00000184347" } ] } } ], "crossref": [ { "id": "ENSG00000184347", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184347", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O75094", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75094", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd00054", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00054", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd00110", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00110", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "SLIT3", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=SLIT3", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "6586", "url": "https://www.ncbi.nlm.nih.gov/gene/6586", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "1750", "url": "https://glyconnect.expasy.org/browser/proteins/1750", "database": "GlyConnect", "categories": [ "Glycoproteomics", "Glycan" ] }, { "id": "11087", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11087", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O75094", "url": "https://www.ebi.ac.uk/intact/interactors/id:O75094*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000152", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000742", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001791", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001791", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001881", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR006207", "url": "https://www.ebi.ac.uk/interpro/entry/IPR006207", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009030", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013032", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013320", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR018097", "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:6586", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6586", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603745", "url": "http://www.omim.org/entry/603745", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O75094", "url": "https://www.nextprot.org/entry/NX_O75094", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O75094", "url": "https://oglcnac.org/atlas/detail/O75094", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O75094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75094", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PACNANS", "url": "https://omabrowser.org/oma/group/PACNANS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "5475408at2759", "url": "http://www.orthodb.org/?query=5475408at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45836", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45836", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45836:SF9", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45836:SF9", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00008", "url": "http://pfam.xfam.org/family/PF00008", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01462", "url": "http://pfam.xfam.org/family/PF01462", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01463", "url": "http://pfam.xfam.org/family/PF01463", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF02210", "url": "http://pfam.xfam.org/family/PF02210", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12661", "url": "http://pfam.xfam.org/family/PF12661", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O75094", "url": "https://pharos.nih.gov/targets/O75094", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75094", "url": "http://purl.obolibrary.org/obo/PR_O75094", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-373752", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373752", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-428542", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-428542", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O75094", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75094-1", "url": "https://www.uniprot.org/uniprot/O75094-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75094-2", "url": "https://www.uniprot.org/uniprot/O75094-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75094-3", "url": "https://www.uniprot.org/uniprot/O75094-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75094-4", "url": "https://www.uniprot.org/uniprot/O75094-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS", "length": 1523, "header": "sp|O75094-1|SLIT3_HUMAN Isoform 1 of Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=2 SV=3 CANONICAL=O75094-1" }, "isoforms": [ { "isoform_ac": "O75094-1", "url": "", "sequence": { "sequence": "MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS", "length": 1523, "header": "sp|O75094-1|SLIT3_HUMAN Isoform 1 of Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=2 SV=3 CANONICAL=O75094-1" }, "locus": { "chromosome": "5", "start_pos": 169300709, "end_pos": 168666457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000519560.6", "url": "https://www.ensembl.org/id/ENST00000519560.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000430333.2", "url": "https://www.ensembl.org/id/ENSP00000430333.2" } ] } }, { "isoform_ac": "O75094-2", "url": "", "sequence": { "sequence": "MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS", "length": 1423, "header": "sp|O75094-2|SLIT3_HUMAN Isoform 2 of Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=2 SV=3 CANONICAL=O75094-1" }, "locus": {} }, { "isoform_ac": "O75094-3", "url": "", "sequence": { "sequence": "MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQVFRAQVFQSSLPGNCSWSCWPPRPPMP", "length": 1472, "header": "sp|O75094-3|SLIT3_HUMAN Isoform 3 of Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=2 SV=3 CANONICAL=O75094-1" }, "locus": {} }, { "isoform_ac": "O75094-4", "url": "", "sequence": { "sequence": "MAPGWAGVGAAVRARLALALALASVLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIVKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPTHRFQCKVLWFCCPGPVDINIVAKCNACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKLITVNFVGKDSYVELASAKVRPQANISLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTDRPLGGFHGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECRGGCGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLACS", "length": 1530, "header": "sp|O75094-4|SLIT3_HUMAN Isoform 4 of Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=2 SV=3 CANONICAL=O75094-1" }, "locus": { "chromosome": "5", "start_pos": 169300709, "end_pos": 168666457, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000332966.8", "url": "https://www.ensembl.org/id/ENST00000332966.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000332164.8", "url": "https://www.ensembl.org/id/ENSP00000332164.8" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1008, "start_aa": "Asn", "end_pos": 1008, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1008", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1025, "start_aa": "Asn", "end_pos": 1025, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1025", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1067, "start_aa": "Ser", "end_pos": 1067, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1067", "evidence": [ { "id": "O75094", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75094" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "O75094", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O75094" } ] }, { "glytoucan_ac": "G06110VR", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 1181, "start_aa": "Asn", "end_pos": 1181, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1181", "evidence": [ { "id": "1750", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1750" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1181, "start_aa": "Asn", "end_pos": 1181, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1181", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1247, "start_aa": "Asn", "end_pos": 1247, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1247", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "QGTDRPLGGFHGCIHEVR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1293, "start_aa": "Gln", "end_pos": 1310, "end_aa": "Arg", "evidence": [ { "id": "O75094", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 1295, "start_aa": "Thr", "end_pos": 1295, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1295", "evidence": [ { "id": "O75094", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 1406, "start_aa": "Asn", "end_pos": 1406, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn1406", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 192, "start_aa": "Asn", "end_pos": 192, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn192", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 563, "start_aa": "Asn", "end_pos": 563, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn563", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 622, "start_aa": "Asn", "end_pos": 622, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn622", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 72, "start_aa": "Asn", "end_pos": 72, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn72", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 784, "start_aa": "Asn", "end_pos": 784, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn784", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 792, "start_aa": "Asn", "end_pos": 792, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn792", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 797, "start_aa": "Asn", "end_pos": 797, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn797", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 928, "start_aa": "Asn", "end_pos": 928, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn928", "evidence": [ { "id": "O75094", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75094#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_predicted", "glycoprotein_reported" ], "publication": [ { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology", "journal": "EMBO J", "date": "2013", "authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.", "evidence": [ { "database": "UniCarbKB", "id": "O75094", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching.", "journal": "Cell", "date": "1999", "authors": "Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "10102266", "url": "https://glygen.org/publication/PubMed/10102266" } ] }, { "title": "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.", "journal": "Cell", "date": "1999", "authors": "Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "10102268", "url": "https://glygen.org/publication/PubMed/10102268" } ] }, { "title": "Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis.", "journal": "Mech. Dev.", "date": "1998", "authors": "Holmes G P, Negus K, Burridge L, Raman S, Algar E, Yamada T, Little M H", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "reference": [ { "type": "PubMed", "id": "10349621", "url": "https://glygen.org/publication/PubMed/10349621" } ] }, { "title": "Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.", "journal": "Cell", "date": "2000", "authors": "Bashaw GJ, Kidd T, Murray D, Pawson T, Goodman CS", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "10892742", "url": "https://glygen.org/publication/PubMed/10892742" } ] }, { "title": "Characterization of Slit protein interactions with glypican-1.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Ronca F, Andersen JS, Paech V, Margolis RU", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "11375980", "url": "https://glygen.org/publication/PubMed/11375980" } ] }, { "title": "ERM proteins and merlin: integrators at the cell cortex.", "journal": "Nature reviews. Molecular cell biology", "date": "2002", "authors": "Bretscher A, Edwards K, Fehon RG", "evidence": [ { "database": "Reactome", "id": "R-HSA-373752", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373752" } ], "reference": [ { "type": "PubMed", "id": "12154370", "url": "https://glygen.org/publication/PubMed/12154370" } ] }, { "title": "Movement through Slits: cellular migration via the Slit family.", "journal": "BioEssays : news and reviews in molecular, cellular and developmental biology", "date": "2003", "authors": "Piper M, Little M", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "12508280", "url": "https://glygen.org/publication/PubMed/12508280" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "Structural determinants of heparan sulfate interactions with Slit proteins.", "journal": "Biochemical and biophysical research communications", "date": "2004", "authors": "Zhang F, Ronca F, Linhardt RJ, Margolis RU", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "15063764", "url": "https://glygen.org/publication/PubMed/15063764" } ] }, { "title": "DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin.", "journal": "European journal of cell biology", "date": "2006", "authors": "Martin M, Simon-Assmann P, Kedinger M, Martin M, Mangeat P, Real FX, Fabre M", "evidence": [ { "database": "Reactome", "id": "R-HSA-373752", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373752" } ], "reference": [ { "type": "PubMed", "id": "16762451", "url": "https://glygen.org/publication/PubMed/16762451" } ] }, { "title": "Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains.", "journal": "Molecular and cellular neurosciences", "date": "2007", "authors": "Qin S, Yu L, Gao Y, Zhou R, Zhang C", "evidence": [ { "database": "Reactome", "id": "R-HSA-373752", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373752" } ], "reference": [ { "type": "PubMed", "id": "17174565", "url": "https://glygen.org/publication/PubMed/17174565" } ] }, { "title": "Slit-2/Robo-1 modulates the CXCL12/CXCR4-induced chemotaxis of T cells.", "journal": "Journal of leukocyte biology", "date": "2007", "authors": "Prasad A, Qamri Z, Wu J, Ganju RK", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "17565045", "url": "https://glygen.org/publication/PubMed/17565045" } ] }, { "title": "Proteomic analysis of potential keratan sulfate, chondroitin sulfate A, and hyaluronic acid molecular interactions.", "journal": "Investigative ophthalmology & visual science", "date": "2010", "authors": "Conrad AH, Zhang Y, Tasheva ES, Conrad GW", "evidence": [ { "database": "Reactome", "id": "R-HSA-376176", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-376176" } ], "reference": [ { "type": "PubMed", "id": "20375348", "url": "https://glygen.org/publication/PubMed/20375348" } ] }, { "title": "Melanoma genome sequencing reveals frequent PREX2 mutations.", "journal": "Nature", "date": "2012", "authors": "Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA", "evidence": [ { "database": "dbSNP", "id": "rs35807688", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs35807688" } ], "reference": [ { "type": "PubMed", "id": "22622578", "url": "https://glygen.org/publication/PubMed/22622578" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "O75094", "url": "" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "Robo3.1A suppresses slit-mediated repulsion by triggering degradation of Robo2.", "journal": "Journal of neuroscience research", "date": "2014", "authors": "Li L, Liu S, Lei Y, Cheng Y, Yao C, Zhen X", "evidence": [ { "database": "Reactome", "id": "R-HSA-428542", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-428542" } ], "reference": [ { "type": "PubMed", "id": "24936616", "url": "https://glygen.org/publication/PubMed/24936616" } ] }, { "title": "Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.", "journal": "Science (New York, N.Y.)", "date": "2015", "authors": "Jaworski A, Tom I, Tong RK, Gildea HK, Koch AW, Gonzalez LC, Tessier-Lavigne M", "evidence": [ { "database": "Reactome", "id": "R-HSA-428542", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-428542" } ], "reference": [ { "type": "PubMed", "id": "26586761", "url": "https://glygen.org/publication/PubMed/26586761" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "O75094", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O75094" }, { "database": "O-GlcNAc Atlas", "id": "O75094", "url": "https://oglcnac.org/atlas/detail/O75094" } ], "reference": [ { "type": "PubMed", "id": "28657654", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "title": "Reanalysis of Global Proteomic and Phosphoproteomic Data Identified a Large Number of Glycopeptides.", "journal": "Analytical chemistry", "date": "2018", "authors": "Hu Y, Shah P, Clark DJ, Ao M, Zhang H", "evidence": [ { "database": "GlyConnect", "id": "1750", "url": "https://glyconnect.expasy.org/browser/proteins/1750" } ], "reference": [ { "type": "PubMed", "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "title": "Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women.", "journal": "Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology", "date": "2020", "authors": "Hidalgo-Bravo A, Hernandez-Medrano C, Sevilla-Montoya R, Rivera-Paredez B, Ramirez-Salazar EG, Flores-Morales J, Patino N, Salmeron J, Valdes-Flores M, Velazquez-Cruz R", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" } ], "reference": [ { "type": "PubMed", "id": "32762475", "url": "https://glygen.org/publication/PubMed/32762475" } ] }, { "title": "Isolated congenital diaphragm hernia associated with homozygous SLIT3 gene variant in dizygous twins.", "journal": "European journal of medical genetics", "date": "2021", "authors": "Kaya TB, Aydemir O, Ceylaner S, Ceylaner G, Tekin AN", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" } ], "reference": [ { "type": "PubMed", "id": "33933663", "url": "https://glygen.org/publication/PubMed/33933663" } ] }, { "title": "LncRNA ubiquitin-binding protein domain protein 10 antisense RNA 1 inhibits colon adenocarcinoma progression via the miR-515-5p/slit guidance ligand 3 axis.", "journal": "Bioengineered", "date": "2022", "authors": "Tang Y, Cai J, Lv B", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" } ], "reference": [ { "type": "PubMed", "id": "35034539", "url": "https://glygen.org/publication/PubMed/35034539" } ] }, { "title": "LncRNA PGM5-AS1 Inhibits the Progression of Bladder Cancer by Regulating miR-587/SLIT3 Axis.", "journal": "Critical reviews in eukaryotic gene expression", "date": "2022", "authors": "Duan X, Wang L, Wang Z, Wei W, Wang M, Ding D", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" } ], "reference": [ { "type": "PubMed", "id": "36017912", "url": "https://glygen.org/publication/PubMed/36017912" } ] }, { "title": "Abnormal expression of SLIT3 induces intravillous vascularization dysplasia in ectopic pregnancy.", "journal": "PeerJ", "date": "2023", "authors": "Zhu Qian, Zhao Xiaoya, Zhang Duo, Xia Wei, Zhang Jian", "evidence": [ { "database": "RefSeq", "id": "NP_001258875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258875" } ], "reference": [ { "type": "PubMed", "id": "36793891", "url": "https://glygen.org/publication/PubMed/36793891" } ] }, { "title": "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.", "journal": "Genomics", "date": "1998", "authors": "Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "reference": [ { "type": "PubMed", "id": "9693030", "url": "https://glygen.org/publication/PubMed/9693030" } ] }, { "title": "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.", "journal": "Brain Res. Mol. Brain Res.", "date": "1998", "authors": "Itoh A, Miyabayashi T, Ohno M, Sakano S", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "reference": [ { "type": "PubMed", "id": "9813312", "url": "https://glygen.org/publication/PubMed/9813312" } ] }, { "title": "Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins.", "journal": "Molecular and cellular biology", "date": "1999", "authors": "Hu G, Fearon ER", "evidence": [ { "database": "Reactome", "id": "R-HSA-373752", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-373752" } ], "reference": [ { "type": "PubMed", "id": "9858595", "url": "https://glygen.org/publication/PubMed/9858595" } ] } ], "pathway": [ { "id": "hsa:6586", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:6586", "resource": "KEGG Pathway" }, { "id": "R-HSA-373752", "name": "Netrin-1 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"evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "pmid": "" }, { "name": "aortic valve morphogenesis", "id": "GO:0003180", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003180", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "pmid": "" }, { "name": "Roundabout signaling pathway", "id": "GO:0035385", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035385", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "pmid": "" }, { "name": "axon extension involved in axon guidance", "id": "GO:0048846", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048846", "evidence": [ { "database": "UniProtKB", "id": "O75094", "url": "https://www.uniprot.org/uniprot/O75094" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": 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