{ "uniprot_canonical_ac": "O75051-1", "uniprot_ac": "O75051", "uniprot_id": "PLXA2_HUMAN", "mass": { "chemical_mass": 211104.0, "monoisotopic_mass": 211104.0 }, "refseq": { "ac": "NP_079455", "name": "plexin-A2 precursor", "summary": "This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" }, "gene_names": [ { "name": "PLXNA2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O75051", "id": "O75051" }, { "name": "KIAA0463", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75051", "id": "O75051" }, { "name": "OCT; PLXN2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455", "id": "NP_079455" }, { "name": "OCT", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75051", "id": "O75051" }, { "name": "PLXN2", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75051", "id": "O75051" }, { "name": "PLXNA2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455", "id": "NP_079455" }, { "name": "PRO235", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O75051", "id": "O75051" } ], "protein_names": [ { "name": "Plexin-A2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O75051" }, { "name": "Semaphorin receptor OCT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O75051" }, { "name": "plexin 2; semaphorin receptor OCT; transmembrane protein OCT", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455", "id": "NP_079455" }, { "name": "plexin-A2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455", "id": "NP_079455" } ], "function": [ { "annotation": "Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051#function" }, { "database": "PubMed", "id": "10520995", "url": "https://glygen.org/publication/PubMed/10520995" } ] }, { "annotation": "Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" }, { "database": "PubMed", "id": "25518740", "url": "https://glygen.org/publication/PubMed/25518740" } ] }, { "annotation": "Data suggest that Fyn tyrosine kinase (Fyn)-dependent phosphorylation at two critical tyrosines is a key feature of vertebrate plexin A1 (PlxnA1) and plexin A2 (PlxnA2) signal transduction.", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" }, { "database": "PubMed", "id": "29091353", "url": "https://glygen.org/publication/PubMed/29091353" } ] }, { "annotation": "PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder.", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" }, { "database": "PubMed", "id": "33749153", "url": "https://glygen.org/publication/PubMed/33749153" } ] }, { "annotation": "PLXNA2 as a candidate gene in patients with intellectual disability.", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" }, { "database": "PubMed", "id": "34327814", "url": "https://glygen.org/publication/PubMed/34327814" } ] }, { "annotation": "Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" }, { "database": "PubMed", "id": "36658114", "url": "https://glygen.org/publication/PubMed/36658114" } ] }, { "annotation": "This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs530930724", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs530930724" }, { "id": "rs530930724", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs530930724" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1143, "end_pos": 1143, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPT->NST).", "chr_id": "1", "chr_pos": "208045946", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "P1143", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1286220850", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1286220850" }, { "id": "rs1286220850", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1286220850" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1170, "end_pos": 1170, "sequence_org": "C", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLC->NLS).", "chr_id": "1", "chr_pos": "208045197", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "C1170", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1350018389", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1350018389" }, { "id": "rs1350018389", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1350018389" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 1205, "end_pos": 1205, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->SLT).", "chr_id": "1", "chr_pos": "208045092", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N1205", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1359530306", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1359530306" }, { "id": "rs1359530306", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1359530306" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 1207, "end_pos": 1207, "sequence_org": "T", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->NLI).", "chr_id": "1", "chr_pos": "208045086", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T1207", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O75051", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75051" }, { "id": "rs1411615797", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1411615797" }, { "id": "rs1411615797", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1411615797" }, { "id": "rs1411615797", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1411615797#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 120, "end_pos": 120, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "D", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DYS->NYS).", "chr_id": "1", "chr_pos": "208217565", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "D120", "disease": [ { "disease_id": "DOID:4362", "recommended_name": { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical cancer", "description": "A female reproductive organ cancer that is located_in the cervix." }, "synonyms": [ { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervical neoplasm", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "cervix uteri cancer", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "neoplasm of uterine cervix", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "tumor of the Cervix Uteri", "description": "" }, { "id": "DOID:4362", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4362", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer", "description": "A primary or metastatic malignant neoplasm involving the cervix." }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumor of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cancer of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervical cancer, somatic", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "cervix uteri cancer", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervical tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant cervix uteri tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant neoplasm of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": 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"https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumor of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the cervix uteri", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of the uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant tumour of uterine cervix", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix neoplasm", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumor", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "malignant uterine cervix tumour", "description": "" }, { "id": "MONDO:0002974", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0002974", "name": "uterine cervix cancer", "description": "" }, { "id": "MIM:603956", "resource": "MIM", "url": "https://www.omim.org/entry/603956", "name": "Cervical cancer", "description": "Cervical cancer" } ] } ], 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"https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O75051", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O75051" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051" } ], "common_name": "Human" } ], "gene": [ { "name": "PLXNA2", "url": "https://www.uniprot.org/uniprot/O75051", "locus": { "chromosome": "1", "start_pos": 208022242, "end_pos": 208244384, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000076356", "url": "https://www.ensembl.org/id/ENSG00000076356" } ] } } ], "crossref": [ { "id": "ENSG00000076356", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000076356", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O75051", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O75051", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd00603", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00603", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01179", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01179", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01180", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01180", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd01181", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01181", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd11272", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11272", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd12790", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd12790", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "PLXNA2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PLXNA2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "5362", "url": "https://www.ncbi.nlm.nih.gov/gene/5362", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "9100", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9100", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O75051", "url": "https://www.ebi.ac.uk/intact/interactors/id:O75051*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001627", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001627", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002165", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002165", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR002909", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008936", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008936", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013548", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013548", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR014756", "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016201", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016201", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR031148", "url": "https://www.ebi.ac.uk/interpro/entry/IPR031148", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036352", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036352", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041019", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041019", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR041362", "url": "https://www.ebi.ac.uk/interpro/entry/IPR041362", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042826", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042826", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR046800", "url": "https://www.ebi.ac.uk/interpro/entry/IPR046800", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:5362", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5362", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "601054", "url": "http://www.omim.org/entry/601054", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O75051", "url": "https://www.nextprot.org/entry/NX_O75051", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "CMEGKSH", "url": "https://omabrowser.org/oma/group/CMEGKSH/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1387371at2759", "url": "http://www.orthodb.org/?query=1387371at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR22625", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22625", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22625:SF37", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22625:SF37", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "3Q3J", "url": "https://www.rcsb.org/structure/3Q3J", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01403", "url": "http://pfam.xfam.org/family/PF01403", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01437", "url": "http://pfam.xfam.org/family/PF01437", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01833", "url": "http://pfam.xfam.org/family/PF01833", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08337", "url": "http://pfam.xfam.org/family/PF08337", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF17960", "url": "http://pfam.xfam.org/family/PF17960", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF18020", "url": "http://pfam.xfam.org/family/PF18020", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF20170", "url": "http://pfam.xfam.org/family/PF20170", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O75051", "url": "https://pharos.nih.gov/targets/O75051", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O75051", "url": "http://purl.obolibrary.org/obo/PR_O75051", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O75051", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75051-1", "url": "https://www.uniprot.org/uniprot/O75051-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O75051-2", "url": "https://www.uniprot.org/uniprot/O75051-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES", "length": 1894, "header": "sp|O75051-1|PLXA2_HUMAN Isoform 1 of Plexin-A2 OS=Homo sapiens OX=9606 GN=PLXNA2 PE=1 SV=4 CANONICAL=O75051-1" }, "isoforms": [ { "isoform_ac": "O75051-1", "url": "", "sequence": { "sequence": "MEQRRPWPRALEVDSRSVVLLSVVWVLLAPPAAGMPQFSTFHSENRDWTFNHLTVHQGTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRMTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVLKDGSPILRDMAFSIDQRYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAWEPNRFAASISQCVSLAVHPSSISVSEHSRLLSLVVSDAPDLSAGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINISEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQGAIHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQHCTSPSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGEYIIAEQIVCEMGHALVGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLNPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMSEIVCVSPPSSNGLGPVPVSVSVDRAHVDSNLQFEYIDDPRVQRIEPEWSIASGHTPLTITGFNLDVIQEPRIRVKFNGKESVNVCKVVNTTTLTCLAPSLTTDYRPGLDTVERPDEFGFVFNNVQSLLIYNDTKFIYYPNPTFELLSPTGVLDQKPGSPIILKGKNLCPPASGGAKLNYTVLIGETPCAVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIVSIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRAPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKSWVERYYADIAKLPAISDQDMNAYLAEQSRLHAVEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEQLINAMSIES", "length": 1894, "header": "sp|O75051-1|PLXA2_HUMAN Isoform 1 of Plexin-A2 OS=Homo sapiens OX=9606 GN=PLXNA2 PE=1 SV=4 CANONICAL=O75051-1" }, "locus": { "chromosome": "1", "start_pos": 208217922, "end_pos": 208027246, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000367033.4", "url": "https://www.ensembl.org/id/ENST00000367033.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000356000.3", "url": "https://www.ensembl.org/id/ENSP00000356000.3" } ] } }, { "isoform_ac": "O75051-2", "url": "", "sequence": { "sequence": 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} ] }, { "title": "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.", "journal": "Immunity", "date": "2000", "authors": "Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H", "evidence": [ { "database": "Reactome", "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700" } ], "reference": [ { "type": "PubMed", "id": "11114375", "url": "https://glygen.org/publication/PubMed/11114375" } ] }, { "title": "Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse.", "journal": "Nature neuroscience", "date": "2001", "authors": "Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K, Goshima Y, Yahara I", "evidence": [ { "database": "Reactome", "id": "R-HSA-399954", "url": 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Autophosphorylation events in both regulatory and kinase domains control activity.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Chong C, Tan L, Lim L, Manser E", "evidence": [ { "database": "Reactome", "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954" } ], "reference": [ { "type": "PubMed", "id": "11278486", "url": "https://glygen.org/publication/PubMed/11278486" } ] }, { "title": "Plexin signaling via off-track and rho family GTPases.", "journal": "Neuron", "date": "2001", "authors": "Whitford KL, Ghosh A", "evidence": [ { "database": "Reactome", "id": "R-HSA-399954", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954" } ], "reference": [ { "type": "PubMed", "id": "11604131", "url": "https://glygen.org/publication/PubMed/11604131" } ] }, { "title": "Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling.", "journal": "The EMBO journal", "date": "2002", "authors": "Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "12093729", "url": "https://glygen.org/publication/PubMed/12093729" } ] }, { "title": "Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex.", "journal": "Neuron", "date": "2002", "authors": "Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "12372285", "url": "https://glygen.org/publication/PubMed/12372285" } ] }, { "title": "Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions.", "journal": "Nature", "date": "2002", "authors": "Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA", "evidence": [ { "database": "Reactome", "id": "R-HSA-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955" } ], "reference": [ { "type": "PubMed", "id": "12422220", "url": "https://glygen.org/publication/PubMed/12422220" } ] }, { "title": "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.", "journal": "International immunology", "date": "2003", "authors": "Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H", "evidence": [ { "database": "Reactome", "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700" } ], "reference": [ { "type": "PubMed", "id": "12882840", "url": "https://glygen.org/publication/PubMed/12882840" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "Structural bases for CRMP function in plexin-dependent semaphorin3A signaling.", "journal": "The EMBO journal", "date": "2004", "authors": "Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "14685275", "url": "https://glygen.org/publication/PubMed/14685275" } ] }, { "title": "Plexin-B3 is a functional receptor for semaphorin 5A.", "journal": "EMBO reports", "date": "2004", "authors": "Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, Comoglio PM, Tamagnone L", "evidence": [ { "database": "Reactome", "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700" } ], "reference": [ { "type": "PubMed", "id": "15218527", "url": "https://glygen.org/publication/PubMed/15218527" } ] }, { "title": "Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins.", "journal": "Science (New York, N.Y.)", "date": "2005", "authors": "Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD", "evidence": [ { "database": "Reactome", "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700" } ], "reference": [ { "type": "PubMed", "id": "15550623", "url": "https://glygen.org/publication/PubMed/15550623" } ] }, { "title": "GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity.", "journal": "Cell", "date": "2005", "authors": "Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "15652488", "url": "https://glygen.org/publication/PubMed/15652488" } ] }, { "title": "Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2005", "authors": "Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "15676027", "url": "https://glygen.org/publication/PubMed/15676027" } ] }, { "title": "FARP2 triggers signals for Sema3A-mediated axonal repulsion.", "journal": "Nature neuroscience", "date": "2005", "authors": "Toyofuku T, Yoshida J, Sugimoto T, Zhang H, Kumanogoh A, Hori M, Kikutani H", "evidence": [ { "database": "Reactome", "id": "R-HSA-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955" } ], "reference": [ { "type": "PubMed", "id": "16286926", "url": "https://glygen.org/publication/PubMed/16286926" } ] }, { "title": "Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.", "journal": "Nature cell biology", "date": "2006", "authors": "Takegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, Mizui M, Yamamoto M, Prasad DV, Suzuki K, Ishii M, Terai K, Moriya M, Nakatsuji Y, Sakoda S, Sato S, Akira S, Takeda K, Inui M, Takai T, Ikawa M, Okabe M, Kumanogoh A, Kikutani H", "evidence": [ { "database": "Reactome", "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700" } ], "reference": [ { "type": "PubMed", "id": "16715077", "url": "https://glygen.org/publication/PubMed/16715077" } ] }, { "title": "Repulsion or adhesion: receptors make the call.", "journal": "Current opinion in cell biology", "date": "2006", "authors": "Halloran MC, Wolman MA", "evidence": [ { "database": "Reactome", "id": "R-HSA-399955", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955" } ], "reference": [ { "type": "PubMed", "id": "16930978", "url": "https://glygen.org/publication/PubMed/16930978" } ] }, { "title": "Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.", "journal": "The EMBO journal", "date": "2007", "authors": "Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, Hori M", "evidence": [ { "database": "Reactome", "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700" } ], "reference": [ { "type": "PubMed", "id": "17318185", "url": "https://glygen.org/publication/PubMed/17318185" } ] }, { "title": "The CRMP family of proteins and their role in Sema3A signaling.", "journal": "Advances in experimental medicine and biology", "date": "2007", "authors": "Schmidt EF, Strittmatter SM", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "17607942", "url": "https://glygen.org/publication/PubMed/17607942" } ] }, { "title": "Intracellular kinases in semaphorin signaling.", "journal": "Advances in experimental medicine and biology", "date": "2007", "authors": "Ahmed A, Eickholt BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-399956", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399956" } ], "reference": [ { "type": "PubMed", "id": "17607944", "url": "https://glygen.org/publication/PubMed/17607944" } ] }, { "title": "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.", "journal": "J. Proteome Res.", "date": "2009", "authors": "Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051" } ], "reference": [ { "type": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "O75051-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75051-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051" }, { "database": "iPTMnet", "id": "O75051", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O75051" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.", "journal": "The EMBO journal", "date": "2013", "authors": "Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H", "evidence": [ { "database": "UniCarbKB", "id": "O75051", "url": "" } ], "reference": [ { "type": "PubMed", "id": "23584533", "url": "https://glygen.org/publication/PubMed/23584533" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.", "journal": "Journal of human genetics", "date": "2015", "authors": "Belyk M, Kraft SJ, Brown S", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" } ], "reference": [ { "type": "PubMed", "id": "25518740", "url": "https://glygen.org/publication/PubMed/25518740" } ] }, { "title": "Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.", "journal": "The FEBS journal", "date": "2018", "authors": "St Clair RM, Emerson SE, D'Elia KP, Weir ME, Schmoker AM, Ebert AM, Ballif BA", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" } ], "reference": [ { "type": "PubMed", "id": "29091353", "url": "https://glygen.org/publication/PubMed/29091353" } ] }, { "title": "PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder.", "journal": "Autism research : official journal of the International Society for Autism Research", "date": "2021", "authors": "Pijuan J, Ortigoza-Escobar JD, Ortiz J, Alcala A, Calvo MJ, Cubells M, Hernando-Davalillo C, Palau F, Hoenicka J", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" } ], "reference": [ { "type": "PubMed", "id": "33749153", "url": "https://glygen.org/publication/PubMed/33749153" } ] }, { "title": "PLXNA2 as a candidate gene in patients with intellectual disability.", "journal": "American journal of medical genetics. Part A", "date": "2021", "authors": "Altuame FD, Shamseldin HE, Albatti TH, Hashem M, Ewida N, Abdulwahab F, Alkuraya FS", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" } ], "reference": [ { "type": "PubMed", "id": "34327814", "url": "https://glygen.org/publication/PubMed/34327814" } ] }, { "title": "Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells.", "journal": "Cell death & disease", "date": "2023-01-19", "authors": "Toledano Shira, Sabag Adi D, Ilan Neta, Liburkin-Dan Tanya, Kessler Ofra, Neufeld Gera", "evidence": [ { "database": "RefSeq", "id": "NP_079455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079455" } ], "reference": [ { "type": "PubMed", "id": "36658114", "url": "https://glygen.org/publication/PubMed/36658114" } ] }, { "title": "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1996", "authors": "Maestrini E, Tamagnone L, Longati P, Cremona O, Gulisano M, Bione S, Tamanini F, Neel BG, Toniolo D, Comoglio PM", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051" } ], "reference": [ { "type": "PubMed", "id": "8570614", "url": "https://glygen.org/publication/PubMed/8570614" } ] }, { "title": "CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "1996", "authors": "Herold C, Elhabazi A, Bismuth G, Bensussan A, Boumsell L", "evidence": [ { "database": "Reactome", "id": "R-HSA-416700", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-416700" } ], "reference": [ { "type": "PubMed", "id": "8955171", "url": "https://glygen.org/publication/PubMed/8955171" } ] } ], "pathway": [ { "id": "hsa:5362", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:5362", "resource": "KEGG Pathway" }, { "id": "R-HSA-399954", "name": "Sema3A PAK dependent Axon repulsion", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399954", "resource": "Reactome", "description": "Sema3A PAK dependent Axon repulsion" }, { "id": "R-HSA-399955", "name": "SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-399955", "resource": "Reactome", "description": 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"length": 1894 }, "evidence": [ { "id": "45931664", "url": "http://www.informatics.jax.org/homology/45931664", "database": "MGI" }, { "id": "O75051", "url": "https://omabrowser.org/oma/group/O75051/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9V491-1", "protein_name": "Plexin A, isoform A", "gene_name": "PlexA", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": 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"length": 1945 }, "evidence": [ { "id": "O75051", "url": "https://omabrowser.org/oma/group/O75051/", "database": "OMA" } ], "common_name": "Fruit fly" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "semaphorin receptor complex", "id": "GO:0002116", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002116", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": "https://www.uniprot.org/uniprot/O75051" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 12, "go_terms": [ { "name": "negative regulation of cell adhesion", "id": "GO:0007162", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007162", "evidence": [ { "database": "UniProtKB", "id": "O75051", "url": 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