{ "uniprot_canonical_ac": "O60861-3", "uniprot_ac": "O60861", "uniprot_id": "GAS7_HUMAN", "mass": { "chemical_mass": 54371.0, "monoisotopic_mass": 54371.0 }, "refseq": { "ac": "NP_001124303", "name": "growth arrest-specific protein 7 isoform d", "summary": "Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" }, "gene_names": [ { "name": "GAS7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60861", "id": "O60861" }, { "name": "GAS7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303", "id": "NP_001124303" }, { "name": "KIAA0394", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60861", "id": "O60861" } ], "protein_names": [ { "name": "Growth arrest-specific protein 7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60861" }, { "name": "GAS-7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60861" }, { "name": "growth arrest-specific protein 7 isoform d", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303", "id": "NP_001124303" } ], "function": [ { "annotation": "Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" }, { "database": "PubMed", "id": "35400990", "url": "https://glygen.org/publication/PubMed/35400990" } ] }, { "annotation": "Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" }, { "database": "PubMed", "id": "36908025", "url": "https://glygen.org/publication/PubMed/36908025" } ] }, { "annotation": "GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" }, { "database": "PubMed", "id": "33602789", "url": "https://glygen.org/publication/PubMed/33602789" } ] }, { "annotation": "Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" }, { "database": "PubMed", "id": "37769891", "url": "https://glygen.org/publication/PubMed/37769891" } ] }, { "annotation": "Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" } ] }, { "annotation": "May play a role in promoting maturation and morphological differentiation of cerebellar neurons.", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861#function" } ] }, { "annotation": "Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" }, { "database": "PubMed", "id": "38240248", "url": "https://glygen.org/publication/PubMed/38240248" } ] }, { "annotation": "This work reports the identification of two human Gas7 cDNA: hGas7-a with 2,427 nucleotides, which encodes 330 amino acids, and hGas7-b with 2,610 nucleotides, which encodes 412 amino acids according to predicted open-reading-frames.", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" }, { "database": "PubMed", "id": "15948147", "url": "https://glygen.org/publication/PubMed/15948147" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O60861", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O60861" } ], "glycoeffect": [], "start_pos": 340, "end_pos": 340, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "Q", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "17", "chr_pos": "9925595", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "R340", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. 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"MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 476, "header": "sp|O60861-3|GAS7_HUMAN Isoform 3 of Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7 PE=1 SV=3 CANONICAL=O60861-3" }, "isoforms": [ { "isoform_ac": "O60861-1", "url": "", "sequence": { "sequence": "MVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 412, "header": "sp|O60861-1|GAS7_HUMAN Isoform 1 of Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7 PE=1 SV=3 CANONICAL=O60861-3" }, "locus": { "chromosome": "17", "start_pos": 10019888, "end_pos": 9917231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000542249.5", "url": "https://www.ensembl.org/id/ENST00000542249.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000443265.2", "url": "https://www.ensembl.org/id/ENSP00000443265.2" } ] } }, { "isoform_ac": "O60861-2", "url": "", "sequence": { "sequence": "MSNMENSFDDVSCLSPQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 336, "header": "sp|O60861-2|GAS7_HUMAN Isoform 2 of Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7 PE=1 SV=3 CANONICAL=O60861-3" }, "locus": { "chromosome": "17", "start_pos": 9959306, "end_pos": 9917231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000580865.5", "url": "https://www.ensembl.org/id/ENST00000580865.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000463873.1", "url": "https://www.ensembl.org/id/ENSP00000463873.1" } ] } }, { "isoform_ac": "O60861-3", "url": "", "sequence": { "sequence": "MSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLEKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 476, "header": "sp|O60861-3|GAS7_HUMAN Isoform 3 of Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7 PE=1 SV=3 CANONICAL=O60861-3" }, "locus": { "chromosome": "17", "start_pos": 10198390, "end_pos": 9917231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000432992.7", "url": "https://www.ensembl.org/id/ENST00000432992.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000407552.2", "url": "https://www.ensembl.org/id/ENSP00000407552.2" } ] } }, { "isoform_ac": "O60861-4", "url": "", "sequence": { "sequence": "MKPGMVPPPPGEESQTVILPPGWQSYLSPQGRRYYVNTTTNETTWERPSSSPGIPASPGSHRSSLPPTVNGYHASGTPAHPPETAHMSVRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLASQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 416, "header": "sp|O60861-4|GAS7_HUMAN Isoform 4 of Growth arrest-specific protein 7 OS=Homo sapiens OX=9606 GN=GAS7 PE=1 SV=3 CANONICAL=O60861-3" }, "locus": { "chromosome": "17", "start_pos": 10039744, "end_pos": 9917231, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000323816.8", "url": "https://www.ensembl.org/id/ENST00000323816.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000322608.5", "url": "https://www.ensembl.org/id/ENSP00000322608.5" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 117, "end_pos": 117, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O60861", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60861" } ], "site_lbl": "Ser117" }, { "start_pos": 163, "end_pos": 163, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "site_lbl": "Ser163" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2000", "authors": "Megonigal MD, Cheung NK, Rappaport EF, Nowell PC, Wilson RB, Jones DH, Addya K, Leonard DG, Kushner BH, Williams TM, Lange BJ, Felix CA", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "reference": [ { "type": "PubMed", "id": "10706619", "url": "https://glygen.org/publication/PubMed/10706619" } ] }, { "title": "Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth.", "journal": "Journal of neuroscience research", "date": "2005", "authors": "Chao CC, Chang PY, Lu HH", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" } ], "reference": [ { "type": "PubMed", "id": "15948147", "url": "https://glygen.org/publication/PubMed/15948147" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" }, { "database": "iPTMnet", "id": "O60861", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60861" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "GAS7 Deficiency Promotes Metastasis in MYCN-Driven Neuroblastoma.", "journal": "Cancer research", "date": "2021", "authors": "Dong Z, Yeo KS, Lopez G, Zhang C, Dankert Eggum EN, Rokita JL, Ung CY, Levee TM, Her ZP, Howe CJ, Hou X, van Ree JH, Li S, He S, Tao T, Fritchie K, Torres-Mora J, Lehman JS, Meves A, Razidlo GL, Rathi KS, Weroha SJ, Look AT, van Deursen JM, Li H, Westendorf JJ, Maris JM, Zhu S", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" } ], "reference": [ { "type": "PubMed", "id": "33602789", "url": "https://glygen.org/publication/PubMed/33602789" } ] }, { "title": "Association of ABCA1 (rs2472493) and GAS7 (rs9913911) gene variants with primary open-angle glaucoma in a Brazilian population.", "journal": "Molecular vision", "date": "2022", "authors": "Araki MVR, Silva YCO, Rodrigues TAR, Bajano FF, de Souza BB, Costa FF, Costa VP, de Melo MB, de Vasconcellos JPC", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" } ], "reference": [ { "type": "PubMed", "id": "35400990", "url": "https://glygen.org/publication/PubMed/35400990" } ] }, { "title": "Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.", "journal": "Epigenetics", "date": "2023-12", "authors": "Dai Cheng, Dai Shi-Yuan, Gao Yan, Yan Ting, Zhou Qi-Yin, Liu Shi-Jun, Liu Xuan, Deng Dan-Ni, Wang Dong-Hong, Qin Qing-Feng, Zi Dan", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" } ], "reference": [ { "type": "PubMed", "id": "36908025", "url": "https://glygen.org/publication/PubMed/36908025" } ] }, { "title": "Gas7 attenuates hepatocellular carcinoma progression and chemoresistance through the PI3K/Akt signaling pathway.", "journal": "Cellular signalling", "date": "2023-09-27", "authors": "Liu Wen-Feng, Zhang Qi-Wei, Quan Bing, Zhang Feng, Li Miao, Lu Shen-Xin, Dong Ling, Yin Xin, Liu Bin-Bin", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" } ], "reference": [ { "type": "PubMed", "id": "37769891", "url": "https://glygen.org/publication/PubMed/37769891" } ] }, { "title": "Single-nucleotide polymorphisms of TLR4 and GAS7 linked to primary open-angle glaucoma among patients of Shenyang, China.", "journal": "Experimental biology and medicine (Maywood, N.J.)", "date": "2023-12", "authors": "Jie Jiao, Wu Tengfei", "evidence": [ { "database": "RefSeq", "id": "NP_001124303", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124303" } ], "reference": [ { "type": "PubMed", "id": "38240248", "url": "https://glygen.org/publication/PubMed/38240248" } ] } ], "pathway": [ { "id": "hsa:8522", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8522", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O55148-1", "protein_name": "Growth arrest-specific protein 7", "gene_name": "Gas7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MATALQKPGMVPPPPGEESQTVILPPGWHSYLSPQGRRYYVNTTTNETTWERPSSSPGISASPGPHRSSLPTTVNGYHASGTPAHPPETAHMSLRKSTGDSQNLGSSSPGRKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLGESRYASVEKARKALTERQKDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 422 }, "evidence": [ { "id": "45928087", "url": "http://www.informatics.jax.org/homology/45928087", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q60780-1", "protein_name": "Growth arrest-specific protein 7", "gene_name": "Gas7", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MATALQKPGMVPPPPGEESQTVILPPGWHSYLSPQGRRYYVNTTTNETTWERPSSSPGISASPAPHRSSLPTTVNGYHASGTPAHPPETAHMSLRKSTGDSQNLGSSSPGRKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEEYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQKDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI", "length": 421 }, "evidence": [ { "id": "45928087", "url": "http://www.informatics.jax.org/homology/45928087", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "neuron projection morphogenesis", "id": "GO:0048812", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048812", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "pmid": "" }, { "name": "actin filament polymerization", "id": "GO:0030041", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030041", "evidence": [ { "database": "UniProtKB", "id": "O60861", "url": "https://www.uniprot.org/uniprot/O60861" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 101, "end_pos": 103, "annotation": "n_glycosylation_sequon" }, { "start_pos": 214, "end_pos": 216, "annotation": "n_glycosylation_sequon" }, { "start_pos": 363, "end_pos": 365, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 97, "end_pos": 99, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 340 ], "glycation_sites": [], "phosphorylation_sites": [ 117, 163 ], "sequon_annotation_sites": [ { "start_pos": 101, "end_pos": 103 }, { "start_pos": 214, "end_pos": 216 }, { "start_pos": 363, "end_pos": 365 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 97, "end_pos": 99 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 8 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }