{ "uniprot_canonical_ac": "O60831-1", "uniprot_ac": "O60831", "uniprot_id": "PRAF2_HUMAN", "mass": { "chemical_mass": 19258.0, "monoisotopic_mass": 19258.0 }, "refseq": { "ac": "NP_009144", "name": "PRA1 family protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, "gene_names": [ { "name": "PRAF2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60831", "id": "O60831" }, { "name": "JM4; Yip6a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144", "id": "NP_009144" }, { "name": "JM4", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60831", "id": "O60831" }, { "name": "PRAF2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144", "id": "NP_009144" } ], "protein_names": [ { "name": "PRA1 family protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60831" }, { "name": "Jena-Muenchen 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144", "id": "NP_009144" }, { "name": "PRA1 family protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144", "id": "NP_009144" } ], "function": [ { "annotation": "CCR5-interacting PRAF2 protein is expressed in several human tissues with a possible function in ER/Golgi transport and vesicular traffic.", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, { "database": "PubMed", "id": "16481131", "url": "https://glygen.org/publication/PubMed/16481131" } ] }, { "annotation": "Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, { "database": "PubMed", "id": "38139265", "url": "https://glygen.org/publication/PubMed/38139265" } ] }, { "annotation": "May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "O60831", "url": "https://www.uniprot.org/uniprot/O60831#function" }, { "database": "PubMed", "id": "18395978", "url": "https://glygen.org/publication/PubMed/18395978" }, { "database": "PubMed", "id": "17975142", "url": "https://glygen.org/publication/PubMed/17975142" } ] }, { "annotation": "PRAF2 (JM4) is CCR5-interacting protein, which is suggested to function in trafficking and membrane localisation of the receptor.", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, { "database": "PubMed", "id": "15757671", "url": "https://glygen.org/publication/PubMed/15757671" } ] }, { "annotation": "PRAF2 could be used as a potential prognostic biomarker and represent a potential therapeutic target for ESCC. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, { "database": "PubMed", "id": "31200670", "url": "https://glygen.org/publication/PubMed/31200670" } ] }, { "annotation": "PRAF2 has a role in progression of neuroblastoma", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, { "database": "PubMed", "id": "17975142", "url": "https://glygen.org/publication/PubMed/17975142" } ] }, { "annotation": "PRAF2 plays an essential role in neuroblastoma tumorigenesis and metastasis.", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, { "database": "PubMed", "id": "23440329", "url": "https://glygen.org/publication/PubMed/23440329" } ] }, { "annotation": "The expression of PRAF2 in specific regions of the brain including SVs suggest an important physiological function for this novel protein, possibly by participating in multiple aspects of SV maturation, transport, and signal transmission.", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" }, { "database": "PubMed", "id": "18395978", "url": "https://glygen.org/publication/PubMed/18395978" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "90.66", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "92.51", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "84.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "93.31", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "91.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "72.66", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "90.72", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "88.89", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000243279", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000243279" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60831", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60831" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", 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"MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": 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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", 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"MSEVRLPPLRALDDFVLGSARLAAPDPCDPQRWCHRVINNLLYYQTNYLLCFGIGLALAGYVRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVGLLVLWVAGGACTFLFSIAGPVLLILVHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178, "header": "sp|O60831-1|PRAF2_HUMAN Isoform 1 of PRA1 family protein 2 OS=Homo sapiens OX=9606 GN=PRAF2 PE=1 SV=1 CANONICAL=O60831-1" }, "locus": { "chromosome": "X", "start_pos": 49073987, "end_pos": 49071872, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000553851.3", "url": "https://www.ensembl.org/id/ENST00000553851.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000451962.2", "url": "https://www.ensembl.org/id/ENSP00000451962.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O60831", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60831" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "JM4 is a four-transmembrane protein binding to the CCR5 receptor.", "journal": "FEBS Lett.", "date": "2005", "authors": "Schweneker M, Bachmann AS, Moelling K", "evidence": [ { "database": "UniProtKB", "id": "O60831", "url": "https://www.uniprot.org/uniprot/O60831" }, { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" } ], "reference": [ { "type": "PubMed", "id": "15757671", "url": "https://glygen.org/publication/PubMed/15757671" } ] }, { "title": "Genomic organization, characterization, and molecular 3D model of GDE1, a novel mammalian glycerophosphoinositol phosphodiesterase.", "journal": "Gene", "date": "2006", "authors": "Bachmann AS, Duennebier FF, Mocz G", "evidence": [ { "database": "UniProtKB", "id": "O60831", "url": "https://www.uniprot.org/uniprot/O60831" } ], "reference": [ { "type": "PubMed", "id": "16472945", "url": "https://glygen.org/publication/PubMed/16472945" } ] }, { "title": "Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2).", "journal": "Gene", "date": "2006", "authors": "Fo CS, Coleman CS, Wallick CJ, Vine AL, Bachmann AS", "evidence": [ { "database": "UniProtKB", "id": "O60831", "url": "https://www.uniprot.org/uniprot/O60831" }, { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" } ], "reference": [ { "type": "PubMed", "id": "16481131", "url": "https://glygen.org/publication/PubMed/16481131" } ] }, { "title": "Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation.", "journal": "Clinical cancer research : an official journal of the American Association for Cancer Research", "date": "2007", "authors": "Geerts D, Wallick CJ, Koomoa DL, Koster J, Versteeg R, Go RC, Bachmann AS", "evidence": [ { "database": "UniProtKB", "id": "O60831", "url": "https://www.uniprot.org/uniprot/O60831" }, { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" } ], "reference": [ { "type": "PubMed", "id": "17975142", "url": "https://glygen.org/publication/PubMed/17975142" } ] }, { "title": "Expression profile of PRAF2 in the human brain and enrichment in synaptic vesicles.", "journal": "Neuroscience letters", "date": "2008", "authors": "Koomoa DL, Go RC, Wester K, Bachmann AS", "evidence": [ { "database": "UniProtKB", "id": "O60831", "url": "https://www.uniprot.org/uniprot/O60831" }, { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" } ], "reference": [ { "type": "PubMed", "id": "18395978", "url": "https://glygen.org/publication/PubMed/18395978" } ] }, { "title": "PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma.", "journal": "International journal of oncology", "date": "2013", "authors": "Yco LP, Geerts D, Koster J, Bachmann AS", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" } ], "reference": [ { "type": "PubMed", "id": "23440329", "url": "https://glygen.org/publication/PubMed/23440329" } ] }, { "title": "PRAF2 overexpression predicts poor prognosis and promotes tumorigenesis in esophageal squamous cell carcinoma.", "journal": "BMC cancer", "date": "2019", "authors": "Qian Z, Wei B, Zhou Y, Wang Q, Wang J, Sun Y, Gao Y, Chen X", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" } ], "reference": [ { "type": "PubMed", "id": "31200670", "url": "https://glygen.org/publication/PubMed/31200670" } ] }, { "title": "Extracellular arginine availability modulates eIF2\u03b1 O-GlcNAcylation and heme oxygenase 1 translation for cellular homeostasis.", "journal": "Journal of biomedical science", "date": "2023-05-22", "authors": "Hung Yu-Wen, Ouyang Ching, Ping Xiaoli, Qi Yue, Wang Yi-Chang, Kung Hsing-Jien, Ann David K", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60831", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60831" } ], "reference": [ { "type": "PubMed", "id": "37217939", "url": "https://glygen.org/publication/PubMed/37217939" } ] }, { "title": "Control of CCR5 Cell-Surface Targeting by the PRAF2 Gatekeeper.", "journal": "International journal of molecular sciences", "date": "2023-12-13", "authors": "Da Silva Elisa, Scott Mark G H, Enslen Herv\u00e9, Marullo Stefano", "evidence": [ { "database": "RefSeq", "id": "NP_009144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009144" } ], "reference": [ { "type": "PubMed", "id": "38139265", "url": "https://glygen.org/publication/PubMed/38139265" } ] } ], "pathway": [ { "id": "hsa:11230", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11230", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2JTX2-1", "protein_name": "PRA1 family protein", "gene_name": "Praf2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSEVRLPPLRALDDFVLGSARLAAPDLGDPQRWCHRVINNLLYYQTNYLLCFGISLALAGYIRPLHTLLSALVVAVALGVLVWAAETRAAVRRCRRSHPAACLAAVLAVSLFILWAVGGAFTFLLCITAPVLLILLHASLRLRNLKNKIENKIESIGLKRTPMGLLLEALGQEQEAGS", "length": 178 }, "evidence": [ { "id": "45926088", "url": "http://www.informatics.jax.org/homology/45926088", "database": "MGI" }, { "id": "O60831", "url": "https://omabrowser.org/oma/group/O60831/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9JIG8-1", "protein_name": "PRA1 family protein 2", "gene_name": "Praf2", "tax_id": 10090, 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