{ "uniprot_canonical_ac": "O60733-1", "uniprot_ac": "O60733", "uniprot_id": "PLPL9_HUMAN", "mass": { "chemical_mass": 89903.0, "monoisotopic_mass": 89903.0 }, "refseq": { "ac": "NP_001004426", "name": "85/88 kDa calcium-independent phospholipase A2 isoform b", "summary": "The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426" }, "gene_names": [ { "name": "PLA2G6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60733", "id": "O60733" }, { "name": "CaI-PLA2; GVI; INAD1; iPLA2; IPLA2-VIA; iPLA2beta; NBIA2; NBIA2A; NBIA2B; PARK14; PLA2; PNPLA9", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426", "id": "NP_001004426" }, { "name": "PLA2G6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426", "id": "NP_001004426" }, { "name": "PLPLA9", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60733", "id": "O60733" } ], "protein_names": [ { "name": "85/88 kDa calcium-independent phospholipase A2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60733" }, { "name": "2-lysophosphatidylcholine acylhydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "3.1.1.4", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "3.1.1.5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "3.1.2.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "85 kDa calcium-independent phospholipase A2; GVI PLA2; iPLA2-beta; patatin-like phospholipase domain-containing protein 9; palmitoyl-CoA hydrolase; intracellular membrane-associated calcium-independent phospholipase A2 beta; 85/88 kDa calcium-independent phospholipase A2; neurodegeneration with brain iron accumulation 2; phospholipase A2, group VI (cytosolic, calcium-independent); 2-lysophosphatidylcholine acylhydrolase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426", "id": "NP_001004426" }, { "name": "85/88 kDa calcium-independent phospholipase A2 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426", "id": "NP_001004426" }, { "name": "CaI-PLA2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "GVI PLA2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "Group VI phospholipase A2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "Intracellular membrane-associated calcium-independent phospholipase A2 beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "PNPLA9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "Palmitoyl-CoA hydrolase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "Patatin-like phospholipase domain-containing protein 9", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" }, { "name": "iPLA2-beta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60733" } ], "function": [ { "annotation": "Association between PLA2 gene polymorphisms and treatment response to antipsychotic medications: A study of antipsychotic-naive first-episode psychosis patients and nonadherent chronic psychosis patients.", "evidence": [ { "database": "RefSeq", "id": "NP_001004426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426" }, { "database": "PubMed", "id": "37290257", "url": "https://glygen.org/publication/PubMed/37290257" } ] }, { "annotation": "Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles (PubMed:9417066, PubMed:10092647, PubMed:10336645, PubMed:20886109). Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position (PubMed:10092647, PubMed:10336645, PubMed:20886109). Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) (PubMed:20886109). Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content (PubMed:23533611). Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species (By similarity). Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (By similarity). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle (PubMed:20886109). Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis (PubMed:18208975). Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types (By similarity). Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733#function" }, { "database": "UniProtKB", "id": "A0A3L7I2I8", "url": "https://www.uniprot.org/uniprot/A0A3L7I2I8#function" }, { "database": "PubMed", "id": "18208975", "url": "https://glygen.org/publication/PubMed/18208975" }, { "database": "PubMed", "id": "23533611", "url": "https://glygen.org/publication/PubMed/23533611" }, { "database": "PubMed", "id": "9417066", "url": "https://glygen.org/publication/PubMed/9417066" }, { "database": "PubMed", "id": "10336645", "url": "https://glygen.org/publication/PubMed/10336645" }, { "database": "UniProtKB", "id": "P97819", "url": "https://www.uniprot.org/uniprot/P97819#function" }, { "database": "PubMed", "id": "20886109", "url": "https://glygen.org/publication/PubMed/20886109" }, { "database": "PubMed", "id": "10092647", "url": "https://glygen.org/publication/PubMed/10092647" }, { "database": "UniProtKB", "id": "P97570", "url": "https://www.uniprot.org/uniprot/P97570#function" } ] }, { "annotation": "Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms.", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733#function" }, { "database": "PubMed", "id": "9417066", "url": "https://glygen.org/publication/PubMed/9417066" } ] }, { "annotation": "Mapped a locus for infantile neuroaxonal dystrophy (INAD) and neurodegeneration with brain iron accumulation (NBIA) to chromosome 22q12-q13 and identified mutations in PLA2G6, encoding a group VI phospholipase A2, in NBIA, INAD and Karak syndrome Erratum:[Nat Genet. 2006 Aug;38(8):957]", "evidence": [ { "database": "RefSeq", "id": "NP_001004426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426" }, { "database": "PubMed", "id": "16783378", "url": "https://glygen.org/publication/PubMed/16783378" } ] }, { "annotation": "Phenotype and genotype heterogeneity of PLA2G6-associated neurodegeneration in a cohort of pediatric and adult patients. Erratum:[Orphanet J Rare Dis. 2023 Jul 17;18(1):190. PMID: 37461050] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001004426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426" }, { "database": "PubMed", "id": "37403138", "url": "https://glygen.org/publication/PubMed/37403138" } ] }, { "annotation": "The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010].", "evidence": [ { "database": "RefSeq", "id": "NP_001004426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426" } ] }, { "annotation": "The role of the PLA2G6 gene in neurodegenerative diseases. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_001004426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004426" }, { "database": "PubMed", "id": "37236368", "url": "https://glygen.org/publication/PubMed/37236368" } ] } ], "disease": [ { "disease_id": "DOID:0060900", "recommended_name": { "id": "DOID:0060900", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060900", "name": "Parkinson's disease 14", "description": "A late-onset Parkinson disease that has_material_basis_in homozygous mutation in the PLA2G6 gene on chromosome 22q13." }, "synonyms": [ { "id": "DOID:0060900", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060900", "name": "autosomal recessive Parkinson's disease 14", "description": "" }, { "id": "DOID:0060900", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060900", "name": "Dystonia-Parkinsonism Adult-Onset", "description": "" }, { "id": "DOID:0060900", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0060900", "name": "autosomal recessive Parkinson disease 14", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "autosomal recessive Parkinson disease 14", "description": "A rare neurodegenerative disease usually presenting before the age of 30 and which is characterized by dystonia, L-dopa-responsive parkinsonism, pyramidal signs and rapid cognitive decline." }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "PARK14", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "PLA2G6 hereditary late onset Parkinson disease", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "PLA2G6-related dystonia-parkinsonism", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "autosomal recessive Parkinson disease type 14", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "dystonia-Parkinsonism Adult-onset", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "dystonia-parkinsonism, Paisan-Ruiz type", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "hereditary late onset Parkinson disease caused by mutation in PLA2G6", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "Parkinson disease 14, autosomal recessive", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "adult-onset dystonia - parkinsonism", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "autosomal recessive Parkinson's disease 14", "description": "" }, { "id": "MONDO:0013060", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013060", "name": "dystonia-Parkinsonism, adult-onset", "description": "" }, { "id": "MIM:612953", "resource": "MIM", "url": "https://www.omim.org/entry/612953", "name": "Parkinson disease 14", "description": "Parkinson disease 14" } ], "evidence": [ { "id": "612953", "database": "MIM", "url": "https://www.omim.org/entry/612953" } ] }, { "disease_id": "DOID:0110735", "recommended_name": { "id": "DOID:0110735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110735", "name": "neurodegeneration with brain iron accumulation 2a", "description": "A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PLA2G6 gene on chromosome 22q13.1 and is characterized by onset in the first 2 years of life." }, "synonyms": [ { "id": "DOID:0110735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110735", "name": "INAD1", "description": "" }, { "id": "DOID:0110735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110735", "name": "Infantile Neuroaxonal Dystrophy 1", "description": "" }, { "id": "DOID:0110735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110735", "name": "NBIA2a", "description": "" }, { "id": "DOID:0110735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110735", "name": "Neurodegeneration, Pla2g6-Associated", "description": "" }, { "id": "DOID:0110735", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110735", "name": "Seitelberger Disease", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neurodegeneration with brain iron accumulation 2A", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "Seitelberger disease", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "NBIA2A", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "PLAN", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "inaD", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "infantile neuroaxonal dystrophy", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "infantile neuroaxonal dystrophy 1", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neurodegeneration with brain iron accumulation 2A", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neurodegeneration with brain iron accumulation type 2A", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neurodegeneration with brain iron accumulation type 2a", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neurodegeneration, PLA2G6-associated", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neurodegeneration, Pla2G6-associated", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neurodegeneration, Pla2g6-associated", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "phospholipase A2-associated neurodegeneration", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "Hunter Carpenter Macdonald syndrome", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "Hunter-Carpenter-McDonald syndrome", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "INAD1", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "KARAK syndrome, included", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "infantile neuroaxonal dystrophy/atypical neuroaxonal dystrophy", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neuroaxonal dystrophy presenting with neonatal dysmorphic features, early onset of peripheral gangrene", "description": "" }, { "id": "MONDO:0024457", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0024457", "name": "neuroaxonal dystrophy, infantile", "description": "" }, { "id": "MIM:256600", "resource": "MIM", "url": "https://www.omim.org/entry/256600", "name": "Neurodegeneration with brain iron accumulation 2A", "description": "Neurodegeneration with brain iron accumulation 2A" } ], "evidence": [ { "id": "256600", "database": "MIM", "url": "https://www.omim.org/entry/256600" } ] }, { "disease_id": "DOID:0110736", "recommended_name": { "id": "DOID:0110736", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110736", "name": "neurodegeneration with brain iron accumulation 2b", "description": "A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PLA2G6 gene on chromosome 22q13.1." }, "synonyms": [ { "id": "DOID:0110736", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110736", "name": "NBIA2b", "description": "" }, { "id": "DOID:0110736", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110736", "name": "Neuroaxonal Dystrophy, Atypical", "description": "" }, { "id": "DOID:0110736", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110736", "name": "Neurodegeneration With Brain Iron Accumulation, Pla2g6-Related", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "neurodegeneration with brain iron accumulation 2B", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "NBIA2b", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "neuroaxonal dystrophy, atypical", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "neurodegeneration with brain iron accumulation 2B", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "neurodegeneration with brain iron accumulation type 2B", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "neurodegeneration with brain iron accumulation type 2b", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "neurodegeneration with brain iron accumulation, Pla2g6-related", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "Karak syndrome", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "NBIA2B", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "atypical neuroaxonal dystrophy", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "early-onset progressive cerebellar ataxia dystonia spasticity and intellectual decline", "description": "" }, { "id": "MONDO:0012444", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012444", "name": "neurodegeneration with brain iron accumulation, Pla2G6-related", "description": "" }, { "id": "MIM:610217", "resource": "MIM", "url": "https://www.omim.org/entry/610217", "name": "Neurodegeneration with brain iron accumulation 2B", "description": "Neurodegeneration with brain iron accumulation 2B" } ], "evidence": [ { "id": "610217", "database": "MIM", "url": "https://www.omim.org/entry/610217" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 519, "end_pos": 519, "sequence_org": "S", "sequence_mut": "A", "comment": "Abolishes phospholipase and lysophospholipase activities.", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" }, { "database": "PubMed", "id": "20886109", "url": "https://glygen.org/publication/PubMed/20886109" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "85.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184381", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184381" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "72.44", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184381", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184381" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "83.58", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184381", "url": 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"72.9", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184381", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184381" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "84.92", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184381", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184381" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "96.54", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184381", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184381" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "93.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184381", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184381" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60733", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60733" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" 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"MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial 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"description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60733", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60733" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60733" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O60733", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60733" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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"Protein" ] }, { "id": "H7C3P5-1", "url": "https://www.uniprot.org/uniprot/H7C3P5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R1Q9", "url": "https://www.uniprot.org/uniprot/M0R1Q9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R1Q9-1", "url": "https://www.uniprot.org/uniprot/M0R1Q9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R3D9", "url": "https://www.uniprot.org/uniprot/M0R3D9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "M0R3D9-1", "url": "https://www.uniprot.org/uniprot/M0R3D9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60733-1", "url": "https://www.uniprot.org/uniprot/O60733-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60733-2", "url": "https://www.uniprot.org/uniprot/O60733-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60733-3", "url": "https://www.uniprot.org/uniprot/O60733-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60733-4", "url": "https://www.uniprot.org/uniprot/O60733-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP", "length": 806, "header": "sp|O60733-1|PLPL9_HUMAN Isoform 1 of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2 CANONICAL=O60733-1" }, "isoforms": [ { "isoform_ac": "A0A590UJC7-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRPCPALCLTELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP", "length": 760, "header": "tr|A0A590UJC7-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38112164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000664587.1", "url": "https://www.ensembl.org/id/ENST00000664587.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000499394.1", "url": "https://www.ensembl.org/id/ENSP00000499394.1" } ] } }, { "isoform_ac": "A0A590UJH4-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRSHAQ", "length": 74, "header": "tr|A0A590UJH4-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38147463, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000665987.1", "url": "https://www.ensembl.org/id/ENST00000665987.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000499423.1", "url": "https://www.ensembl.org/id/ENSP00000499423.1" } ] } }, { "isoform_ac": "A0A590UJZ2-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRRLGSSPCVLSPMRLLLVLLVCPSSPVTAT", "length": 99, "header": "tr|A0A590UJZ2-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38148536, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000673413.1", "url": "https://www.ensembl.org/id/ENST00000673413.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000500600.1", "url": "https://www.ensembl.org/id/ENSP00000500600.1" } ] } }, { "isoform_ac": "A0A590UK51-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKAAETVRLSDTSQSNSPIACGWGAWDPEWEASPKIIQQIGSRACSEANKRGSGRAQRLTPVIPALWEAEGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP", "length": 820, "header": "tr|A0A590UK51-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38112164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000668949.1", "url": "https://www.ensembl.org/id/ENST00000668949.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000499711.1", "url": "https://www.ensembl.org/id/ENSP00000499711.1" } ] } }, { "isoform_ac": "A0A590UK67-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQVCGDDHQHGQQPDPQQRPPLRSQPPPLGQERRDGPHAAETGLQREQHQLRGEHGPARGGDAQPLRLCHSAADPRGQRGCPRRARQHPAAPGHVERQRGDDQGPHRVRSRSGHPE", "length": 317, "header": "tr|A0A590UK67-1|A0A590UK67_HUMAN Computationally mapped isoform of Phospholipase A2 group VI OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38129501, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000655142.1", "url": "https://www.ensembl.org/id/ENST00000655142.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000499715.1", "url": "https://www.ensembl.org/id/ENSP00000499715.1" } ] } }, { "isoform_ac": "B0QYE9-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRV", "length": 166, "header": "tr|B0QYE9-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38140065, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000430886.5", "url": "https://www.ensembl.org/id/ENST00000430886.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000395464.1", "url": "https://www.ensembl.org/id/ENSP00000395464.1" } ] } }, { "isoform_ac": "E7EX67-1", "url": "", "sequence": { "sequence": "MDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLGSHPSQAGWWAWGAASDGTTGSHAHLTGPEASVHPGLHEGREADMQNLSP", "length": 226, "header": "tr|E7EX67-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38135062, "end_pos": 38125674, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000448094.5", "url": "https://www.ensembl.org/id/ENST00000448094.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000407106.1", "url": "https://www.ensembl.org/id/ENSP00000407106.1" } ] } }, { "isoform_ac": "F8WEN3-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISSLEGTQWLA", "length": 151, "header": "tr|F8WEN3-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38140142, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000436218.6", "url": "https://www.ensembl.org/id/ENST00000436218.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000401242.1", "url": "https://www.ensembl.org/id/ENSP00000401242.1" } ] } }, { "isoform_ac": "F8WEQ9-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEAD", "length": 79, "header": "tr|F8WEQ9-1|F8WEQ9_HUMAN Computationally mapped isoform of Phospholipase A2 group VI OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=8 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38145626, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000455341.2", "url": "https://www.ensembl.org/id/ENST00000455341.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000393761.2", "url": "https://www.ensembl.org/id/ENSP00000393761.2" } ] } }, { "isoform_ac": "H0Y6T3-1", "url": "", "sequence": { "sequence": "MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEY", "length": 439, "header": "tr|H0Y6T3-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38143179, "end_pos": 38115548, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427114.6", "url": "https://www.ensembl.org/id/ENST00000427114.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000407743.2", "url": "https://www.ensembl.org/id/ENSP00000407743.2" } ] } }, { "isoform_ac": "H0Y7G5-1", "url": "", "sequence": { "sequence": "XLVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMI", "length": 197, "header": "tr|H0Y7G5-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38143214, "end_pos": 38129541, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000452542.5", "url": "https://www.ensembl.org/id/ENST00000452542.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000412629.1", "url": "https://www.ensembl.org/id/ENSP00000412629.1" } ] } }, { "isoform_ac": "H7C3P5-1", "url": "", "sequence": { "sequence": "XDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKLDQSDTPPALPERACFAGMVRGEAHLSRTEGDADRDTV", "length": 168, "header": "tr|H7C3P5-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38126442, "end_pos": 38116186, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000454670.1", "url": "https://www.ensembl.org/id/ENST00000454670.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000413145.1", "url": "https://www.ensembl.org/id/ENSP00000413145.1" } ] } }, { "isoform_ac": "M0R1Q9-1", "url": "", "sequence": { "sequence": "MDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAE", "length": 120, "header": "tr|M0R1Q9-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=1 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38143179, "end_pos": 38134988, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000498338.1", "url": "https://www.ensembl.org/id/ENST00000498338.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000472058.1", "url": "https://www.ensembl.org/id/ENSP00000472058.1" } ] } }, { "isoform_ac": "M0R3D9-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNT", "length": 50, "header": "tr|M0R3D9-1|PLPL9_HUMAN Computationally mapped isoform of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=8 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38169277, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000594306.1", "url": "https://www.ensembl.org/id/ENST00000594306.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000473160.1", "url": "https://www.ensembl.org/id/ENSP00000473160.1" } ] } }, { "isoform_ac": "O60733-1", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP", "length": 806, "header": "sp|O60733-1|PLPL9_HUMAN Isoform 1 of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38112164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000332509.8", "url": "https://www.ensembl.org/id/ENST00000332509.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000333142.3", "url": "https://www.ensembl.org/id/ENSP00000333142.3" } ] } }, { "isoform_ac": "O60733-2", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRQLQDLMHISRARKPAFILGSMRDEKRTHDHLLCLDGGGVKGLIIIQLLIAIEKASGVATKDLFDWVAGTSTGGILALAILHSKSMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDVRKPKVMLTGTLSDRQPAELHLFRNYDAPETVREPRFNQNVNLRPPAQPSDQLVWRAARSSGAAPTYFRPNGRFLDGGLLANNPTLDAMTEIHEYNQDLIRKGQANKVKKLSIVVSLGTGRSPQVPVTCVDVFRPSNPWELAKTVFGAKELGKMVVDCCTDPDGRAVDRARAWCEMVGIQYFRLNPQLGTDIMLDEVSDTVLVNALWETEVYIYEHREEFQKLIQLLLSP", "length": 752, "header": "sp|O60733-2|PLPL9_HUMAN Isoform 2 of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2 CANONICAL=O60733-1" }, "locus": { "chromosome": "22", "start_pos": 38169426, "end_pos": 38112164, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000335539.7", "url": "https://www.ensembl.org/id/ENST00000335539.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000335149.3", "url": "https://www.ensembl.org/id/ENSP00000335149.3" } ] } }, { "isoform_ac": "O60733-3", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRLFQLELEADALVNFHQYSSQLLPFYESSPQVLHTEVLQHLTDLIRNHPSWSVAHLAVELGIRECFHHSRIISCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLELQDLMHISRARKPAFILGSMRDEKRTCRT", "length": 479, "header": "sp|O60733-3|PLPL9_HUMAN Isoform 3 of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2 CANONICAL=O60733-1" }, "locus": {} }, { "isoform_ac": "O60733-4", "url": "", "sequence": { "sequence": "MQFFGRLVNTFSGVTNLFSNPFRVKEVAVADYTSSDRVREEGQLILFQNTPNRTWDCVLVNPRNSQSGFRCANCAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQLLGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGYPIHSAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISLNNLGSHPSQAGWWAWGAVSDGTTGSHAHLTGPEASVHPGLHEGREADMQNLSP", "length": 427, "header": "sp|O60733-4|PLPL9_HUMAN Isoform 4 of 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens OX=9606 GN=PLA2G6 PE=1 SV=2 CANONICAL=O60733-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Pickard RT, Strifler BA, Kramer RM, Sharp JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "10085124", "url": "https://glygen.org/publication/PubMed/10085124" } ] }, { "title": "Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Ma Z, Wang X, Nowatzke W, Ramanadham S, Turk J", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" }, { "database": "Reactome", "id": "R-HSA-1482798", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482798" } ], "reference": [ { "type": "PubMed", "id": "10092647", "url": "https://glygen.org/publication/PubMed/10092647" } ] }, { "title": "Phospholipases and phagocytosis: the role of phospholipid-derived second messengers in phagocytosis.", "journal": "The international journal of biochemistry & cell biology", "date": "1999", "authors": "Lennartz MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485" } ], "reference": [ { "type": "PubMed", "id": "10224668", "url": "https://glygen.org/publication/PubMed/10224668" } ] }, { "title": "The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene.", "journal": "European journal of biochemistry", "date": "1999", "authors": "Larsson Forsell PK, Kennedy BP, Claesson HE", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" }, { "database": "Reactome", "id": "R-HSA-1482798", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482798" } ], "reference": [ { "type": "PubMed", "id": "10336645", "url": "https://glygen.org/publication/PubMed/10336645" } ] }, { "title": "Molecular characterization of cytosolic phospholipase A2-beta.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Song C, Chang XJ, Bean KM, Proia MS, Knopf JL, Kriz RW", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "10358058", "url": "https://glygen.org/publication/PubMed/10358058" } ] }, { "title": "Membrane tubule-mediated reassembly and maintenance of the Golgi complex is disrupted by phospholipase A2 antagonists.", "journal": "Molecular biology of the cell", "date": "1999", "authors": "de Figueiredo P, Polizotto RS, Drecktrah D, Brown WJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "10359595", "url": "https://glygen.org/publication/PubMed/10359595" } ] }, { "title": "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482839" } ], "reference": [ { "type": "PubMed", "id": "10455175", "url": "https://glygen.org/publication/PubMed/10455175" } ] }, { "title": "Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum.", "journal": "Nature cell biology", "date": "1999", "authors": "Girod A, Storrie B, Simpson JC, Johannes L, Goud B, Roberts LM, Lord JM, Nilsson T, Pepperkok R", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "10559986", "url": "https://glygen.org/publication/PubMed/10559986" } ] }, { "title": "Rab6 coordinates a novel Golgi to ER retrograde transport pathway in live cells.", "journal": "The Journal of cell biology", "date": "1999", "authors": "White J, Johannes L, Mallard F, Girod A, Grill S, Reinsch S, Keller P, Tzschaschel B, Echard A, Goud B, Stelzer EH", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "10562278", "url": "https://glygen.org/publication/PubMed/10562278" } ] }, { "title": "Phospholipase C-gamma as a signal-transducing element.", "journal": "Experimental cell research", "date": "1999", "authors": "Carpenter G, Ji Qs", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485" } ], "reference": [ { "type": "PubMed", "id": "10579907", "url": "https://glygen.org/publication/PubMed/10579907" } ] }, { "title": "Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Suzuki N, Ishizaki J, Yokota Y, Higashino K, Ono T, Ikeda M, Fujii N, Kawamoto K, Hanasaki K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482839" } ], "reference": [ { "type": "PubMed", "id": "10681567", "url": "https://glygen.org/publication/PubMed/10681567" } ] }, { "title": "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482839" } ], "reference": [ { "type": "PubMed", "id": "11031251", "url": "https://glygen.org/publication/PubMed/11031251" } ] }, { "title": "The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.", "journal": "Biochimica et biophysica acta", "date": "2000", "authors": "Six DA, Dennis EA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "11080672", "url": "https://glygen.org/publication/PubMed/11080672" } ] }, { "title": "Cloning and recombinant expression of human group IIF-secreted phospholipase A(2).", "journal": "Biochemical and biophysical research communications", "date": "2000", "authors": "Valentin E, Singer AG, Ghomashchi F, Lazdunski M, Gelb MH, Lambeau G", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482839" } ], "reference": [ { "type": "PubMed", "id": "11112443", "url": "https://glygen.org/publication/PubMed/11112443" } ] }, { "title": "Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.", "journal": "The Journal of cell biology", "date": "2001", "authors": "Marshall JG, Booth JW, Stambolic V, Mak T, Balla T, Schreiber AD, Meyer T, Grinstein S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485" } ], "reference": [ { "type": "PubMed", "id": "11425868", "url": "https://glygen.org/publication/PubMed/11425868" } ] }, { "title": "Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.", "journal": "The EMBO journal", "date": "2001", "authors": "Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "11483508", "url": "https://glygen.org/publication/PubMed/11483508" } ] }, { "title": "Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions.", "journal": "Chemical reviews", "date": "2001", "authors": "Newton AC", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485" } ], "reference": [ { "type": "PubMed", "id": "11749377", "url": "https://glygen.org/publication/PubMed/11749377" } ] }, { "title": "Identification of a soluble form phospholipase A2 receptor as a circulating endogenous inhibitor for secretory phospholipase A2.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Higashino Ki K, Yokota Y, Ono T, Kamitani S, Arita H, Hanasaki K", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482839" } ], "reference": [ { "type": "PubMed", "id": "11830583", "url": "https://glygen.org/publication/PubMed/11830583" } ] }, { "title": "Human epidermis is a novel site of phospholipase B expression.", "journal": "Biochemical and biophysical research communications", "date": "2002", "authors": "Maury E, Prevost MC, Nauze M, Redoules D, Tarroux R, Charveron M, Salles JP, Perret B, Chap H, Gassama-Diagne A", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "12150957", "url": "https://glygen.org/publication/PubMed/12150957" } ] }, { "title": "Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Pan YH, Yu BZ, Singer AG, Ghomashchi F, Lambeau G, Gelb MH, Jain MK, Bahnson BJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482839" } ], "reference": [ { "type": "PubMed", "id": "12161451", "url": "https://glygen.org/publication/PubMed/12161451" } ] }, { "title": "Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Singer AG, Ghomashchi F, Le Calvez C, Bollinger J, Bezzine S, Rouault M, Sadilek M, Nguyen E, Lazdunski M, Lambeau G, Gelb MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482788", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482788" } ], "reference": [ { "type": "PubMed", "id": "12359733", "url": "https://glygen.org/publication/PubMed/12359733" } ] }, { "title": "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.", "journal": "Current biology : CB", "date": "2002", "authors": "Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "12401177", "url": "https://glygen.org/publication/PubMed/12401177" } ] }, { "title": "Phospholipase A2 enzymes.", "journal": "Prostaglandins & other lipid mediators", "date": "2002", "authors": "Kudo I, Murakami M", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "12432908", "url": "https://glygen.org/publication/PubMed/12432908" } ] }, { "title": "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.", "journal": "Nature cell biology", "date": "2002", "authors": "Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "12447383", "url": "https://glygen.org/publication/PubMed/12447383" } ] }, { "title": "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII).", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Murakami M, Masuda S, Shimbara S, Bezzine S, Lazdunski M, Lambeau G, Gelb MH, Matsukura S, Kokubu F, Adachi M, Kudo I", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482839", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482839" } ], "reference": [ { "type": "PubMed", "id": "12522102", "url": "https://glygen.org/publication/PubMed/12522102" } ] }, { "title": "The role of PI3K in immune cells.", "journal": "Nature immunology", "date": "2003", "authors": "Koyasu S", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485" } ], "reference": [ { "type": "PubMed", "id": "12660731", "url": "https://glygen.org/publication/PubMed/12660731" } ] }, { "title": "Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Leverrier Y, Okkenhaug K, Sawyer C, Bilancio A, Vanhaesebroeck B, Ridley AJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2029485", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029485" } ], "reference": [ { "type": "PubMed", "id": "12869549", "url": "https://glygen.org/publication/PubMed/12869549" } ] }, { "title": "Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking.", "journal": "Molecular biology of the cell", "date": "2003", "authors": "Drecktrah D, Chambers K, Racoosin EL, Cluett EB, Gucwa A, Jackson B, Brown WJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811436", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811436" } ], "reference": [ { "type": "PubMed", "id": "12925777", "url": "https://glygen.org/publication/PubMed/12925777" } ] }, { "title": "Remodeling of cardiolipin by phospholipid transacylation.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Xu Y, Kelley RI, Blanck TJ, Schlame M", "evidence": [ { "database": "Reactome", "id": "R-HSA-1482798", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482798" } ], "reference": [ { "type": "PubMed", "id": "14551214", "url": 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"name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "phosphatidylethanolamine catabolic process", "id": "GO:0046338", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046338", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "phosphatidic acid metabolic process", "id": "GO:0046473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046473", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "phosphatidylcholine catabolic process", "id": "GO:0034638", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034638", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "chemotaxis", "id": "GO:0006935", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006935", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "antibacterial humoral response", "id": "GO:0019731", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019731", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "positive regulation of insulin secretion involved in cellular response to glucose stimulus", "id": "GO:0035774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035774", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "Fc-gamma receptor signaling pathway involved in phagocytosis", "id": "GO:0038096", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0038096", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "cardiolipin acyl-chain remodeling", "id": "GO:0035965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035965", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "positive regulation of ceramide biosynthetic process", "id": "GO:2000304", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000304", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "platelet activating factor metabolic process", "id": "GO:0046469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046469", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "cardiolipin biosynthetic process", "id": "GO:0032049", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032049", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" }, { "name": "lipid metabolic process", "id": "GO:0006629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", "evidence": [ { "database": "UniProtKB", "id": "O60733", "url": "https://www.uniprot.org/uniprot/O60733" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 311, "end_pos": 313, "annotation": "n_glycosylation_sequon" }, { "start_pos": 52, "end_pos": 54, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15177", "name": "", "equation": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O54728-1", "O88202-1", "P50393-1", "P97570-1", "P07867-1", "Q5BK26-1", "Q675A5-1", "D3ZRC4-1", "P47712-1", "Q86U10-1", "Q6P1J6-1", "Q9NP80-1", "Q8IY17-4", "P0C869-1", "P11150-1", "O60733-1", "Q8NCC3-1", "Q9UP65-1", "Q6ZV29-1", "A0JNU3-1", "Q8K1N1-1", "P47713-1", "Q3TRM4-1", "Q3TTY0-1", "P0C871-1", "Q8VEB4-1", "A2AJ88-1", "P97819-1", "P27656-1", "Q64GA5-1", "P39105-1", "Q03674-1", "Q04958-1", "Q08108-1", "Q9U969-1", "Q9VMM8-1" ], "evidence": [ { "id": "15177", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15177" } ] }, { "id": "15801", "name": "", "equation": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "P39878-1", "O54728-1", "P04055-1", "P50393-1", "P53817-1", "P51433-1", "Q9QZT3-1", "P14423-1", "O35244-1", "D3Z9B7-1", "D3ZLB5-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "D3ZRC4-1", "Q675A5-1", "D2KX21-1", "Q4KLN5-1", "F7F420-1", "P0C548-1", "P0C869-1", "Q9BZM1-1", "Q8WU67-1", "P14555-1", "P04054-1", "Q9HDD0-1", "Q9UL19-1", "Q9NWW9-1", "Q96KN8-1", "P47712-1", "Q68DD2-1", "Q9NZ20-1", "Q3MJ16-3", "Q9BZM2-1", "P53816-1", "O15496-1", "O60733-1", "Q6P1J6-1", "Q9UNK4-1", "P30041-1", "Q86XP0-1", "Q9UP65-1", "P39877-1", "Q9NZK7-1", "Q5R387-1", "Q9HCN3-1", "Q8NCC3-1", "Q9NP80-1", "Q9NST1-1", "Q96AD5-1", "P41247-1", "P0C871-1", "O08709-1", "Q91ZH7-1", "Q9CPX5-1", "Q9QZU4-1", "Q8R3U1-1", "P31482-1", "P47713-1", "Q9WVF6-1", "Q9Z0Y2-1", "P48076-1", "Q9EPR2-1", "P97391-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q50L43-1", "Q3TTY0-1", "Q64GA5-1", "Q9QUL3-1", "Q9QXX3-1", "Q9QZT4-1", "Q9ESN3-1", "Q8K1N1-1", "Q8VEB4-1", "Q8BZT7-1", "Q91WW7-1", "Q8BJ56-1", "Q8BG37-1", "Q08448-1", "Q7KUD4-1", "Q8IML0-1", "Q9VMM8-1" ], "evidence": [ { "id": "15801", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15801" } ] }, { "id": "16645", "name": "", "equation": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q566R0-1", "O88267-1", "O55171-1", "Q63276-1", "Q8VHK0-1", "Q64559-2", "P80250-1", "P13437-1", "P97570-1", "P08635-1", "P49753-1", "O14734-1", "Q86TX2-1", "Q8N9L9-1", "Q8WXI4-1", "Q6ZUV0-1", "O00154-1", "Q14032-1", "Q8N1Q8-1", "Q5T1C6-1", "P42765-1", "Q9NPJ3-1", "O60733-1", "Q9NV23-1", "Q68D91-1", "Q8VHQ9-1", "Q9CQJ0-1", "Q9QYR7-1", "P58137-1", "O55137-1", "Q6Q2Z6-1", "Q9QYR9-1", "Q91V12-1", "Q91X34-1", "Q8BWT1-1", "Q3UUI3-1", "Q8BL86-1", "P97819-1", "Q8R197-1", "Q9CQR4-1", "P41903-1" ], "evidence": [ { "id": "16645", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16645" } ] }, { "id": "38779", "name": "", "equation": "1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "O54728-1", "P04055-1", "P51433-1", "Q675A5-1", "Q9QZT3-1", "P14423-1", "D3ZRC4-1", "Q9UL19-1", "Q9NWW9-1", "P53816-1", "Q86XP0-1", "Q9BZM2-1", "Q6P1J6-1", "O60733-1", "Q9UNK4-1", "P14555-1", "P04054-1", "Q8NCC3-1", "O15496-1", "Q9UP65-1", "P39877-1", "Q9NZK7-1", "Q9NP80-1", "Q8R3U1-1", "Q50L43-1", "Q9QZT4-1", "Q8VEB4-1", "Q8K1N1-1", "P31482-1", "Q9WVF6-1", "Q9Z0Y2-1", "P97391-1", "P97819-1", "Q3TTY0-1", "Q9QUL3-1", "Q9QXX3-1", "Q64GA5-1", "Q9VMM8-1" ], "evidence": [ { "id": "38779", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/38779" } ] }, { "id": "40427", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "D3ZRC4-1", "P04055-1", "P50393-1", "P18424-1", "P51433-1", "D3Z9B7-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "P53816-1", "Q86XP0-1", "P0C869-1", "P04180-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q9NZ20-1", "P04054-1", "Q3MJ16-3", "Q9UP65-1", "P39877-1", "Q9NP80-1", "P47713-1", "P0C871-1", "Q8R3U1-1", "Q50L43-1", "Q8K1N1-1", "Q9Z0Y2-1", "P97391-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q8BZT7-1", "P16301-1", "Q64GA5-1" ], "evidence": [ { "id": "40427", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40427" } ] }, { "id": "40431", "name": "", "equation": "1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "P51433-1", "P14423-1", "D2KX21-1", "D3ZRC4-1", "Q9HDD0-1", "Q9NWW9-1", "P53816-1", "Q86XP0-1", "P0C869-1", "Q9BZM2-1", "O60733-1", "Q68DD2-1", "Q9NZ20-1", "P14555-1", "P39877-1", "Q9NZK7-1", "Q9NP80-1", "Q9QZU4-1", "Q8R3U1-1", "Q50L43-1", "Q9QZT4-1", "Q8K1N1-1", "P31482-1", "P97391-1", "P97819-1", "Q50L41-1", "Q9QUL3-1", "Q8BZT7-1" ], "evidence": [ { "id": "40431", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40431" } ] }, { "id": "40435", "name": "", "equation": "1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H(+) + hexadecanoate + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P07882-1", "O88202-1", "P97570-1", "O54728-1", "P50393-1", "P70470-1", "P07867-1", "Q5BK26-1", "Q675A5-1", "Q9QYL8-1", "D3ZRC4-1", "D3Z9B7-1", "D4A1I6-1", "D3ZQH6-1", "F1LPY6-1", "D4A328-1", "P19835-1", "Q86U10-1", "P0C869-1", "Q6P1J6-1", "P11150-1", "Q7L5L3-2", "O95372-1", "O75608-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q3MJ16-3", "Q8IY17-4", "Q8NCC3-1", "Q9UP65-1", "Q6ZV29-1", "Q9NP80-1", "P47713-1", "P0C871-1", "Q64285-1", "A0JNU3-1", "Q50L43-1", "Q9WTL7-1", "P97823-1", "Q8VEB4-1", "Q8K1N1-1", "A2AJ88-1", "P97819-1", "Q50L41-1", "Q50L42-1", "Q3TRM4-1", "Q3TTY0-1", "Q99LY2-1", "P27656-1", "Q64GA5-1", "P39105-1", "Q03674-1", "Q9VMM8-1" ], "evidence": [ { "id": "40435", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40435" } ] }, { "id": "40463", "name": "", "equation": "1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "P51433-1", "O60733-1", "P39877-1", "P97391-1", "P97819-1" ], "evidence": [ { "id": "40463", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40463" } ] }, { "id": "40467", "name": "", "equation": "1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z)-octadecenoate + 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "P51433-1", "O60733-1", "P39877-1", "P97391-1", "P97819-1" ], "evidence": [ { "id": "40467", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40467" } ] }, { "id": "40479", "name": "", "equation": "1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "O35264-1", "O35263-1", "P83006-1", "Q9QZT3-1", "A6JJ35-1", "Q8WU67-1", "Q15102-1", "O60733-1", "O15496-1", "P68402-1", "Q13093-1", "Q99487-1", "Q8VDG7-1", "Q60963-1", "Q91ZH7-1", "Q61205-1", "Q61206-1", "P97819-1", "Q9QXX3-1" ], "evidence": [ { "id": "40479", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40479" } ] }, { "id": "40519", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "P50393-1", "Q9QZT3-1", "O60733-1", "P47712-1", "O15496-1", "P47713-1", "P97819-1", "Q9QXX3-1" ], "evidence": [ { "id": "40519", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40519" } ] }, { "id": "40811", "name": "", "equation": "1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "D3ZRC4-1", "O54728-1", "P50393-1", "P18424-1", "P14423-1", "P53816-1", "Q86XP0-1", "Q6P1J6-1", "P04180-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q9NZ20-1", "Q9UNK4-1", "P14555-1", "Q9UP65-1", "Q9NZK7-1", "Q9NP80-1", "Q8R3U1-1", "Q50L43-1", "Q8K1N1-1", "P31482-1", "P47713-1", "Q9WVF6-1", "P97819-1", "Q50L41-1", "Q3TTY0-1", "Q9QUL3-1", "Q8BZT7-1", "P16301-1", "Q64GA5-1", "Q9VMM8-1" ], "evidence": [ { "id": "40811", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40811" } ] }, { "id": "40827", "name": "", "equation": "2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O88202-1", "P97570-1", "Q86U10-1", "O60733-1", "A0JNU3-1", "P97819-1" ], "evidence": [ { "id": "40827", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40827" } ] }, { "id": "40831", "name": "", "equation": "1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+) + sn-glycerol 3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "O60733-1", "P97819-1" ], "evidence": [ { "id": "40831", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/40831" } ] }, { "id": "41067", "name": "", "equation": "1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-O-hexadecyl-sn-glycero-3-phosphocholine + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "P50393-1", "O60733-1", "P47712-1", "Q68DD2-1", "Q9UP65-1", "P47713-1", "P97819-1", "Q50L41-1", "Q64GA5-1" ], "evidence": [ { "id": "41067", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41067" } ] }, { "id": "41223", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53817-1", "P97570-1", "O54728-1", "P04055-1", "O35244-1", "Q9QZT3-1", "P14423-1", "D2KX21-1", "Q9HDD0-1", "Q9UL19-1", "Q9NWW9-1", "P53816-1", "Q6P1J6-1", "O60733-1", "Q9UNK4-1", "P14555-1", "P04054-1", "O15496-1", "Q9UP65-1", "Q9NZK7-1", "P30041-1", "O08709-1", "Q9QZU4-1", "Q8R3U1-1", "P31482-1", "Q9WVF6-1", "Q9Z0Y2-1", "P97819-1", "Q3TTY0-1", "Q9QUL3-1", "Q9QXX3-1", "Q64GA5-1", "Q8BG37-1", "P39105-1", "P36165-1", "Q03674-1", "Q9VMM8-1" ], "evidence": [ { "id": "41223", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/41223" } ] }, { "id": "52812", "name": "", "equation": "1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = (9Z,12Z)-octadecadienoate + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "D3ZRC4-1", "O60733-1", "Q9NP80-1", "Q8K1N1-1", "P97819-1" ], "evidence": [ { "id": "52812", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52812" } ] }, { "id": "63256", "name": "", "equation": "1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "O60733-1", "P97819-1" ], "evidence": [ { "id": "63256", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63256" } ] }, { "id": "63304", "name": "", "equation": "1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + H(+) + hexadecanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P97570-1", "O60733-1", "P97819-1" ], "evidence": [ { "id": "63304", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63304" } ] }, { "id": "R-HSA-1482778", "name": "CL is hydrolyzed to MLCL by PLA2G6 (IM)", "equation": "", "summary": "At the inner mitochondrial membrane (IM), calcium-independent phospholipase A2 gamma (PLA2G6) hydrolyzes, removing one of the acyl chains, cardiolipin (CL) to form monolysocardiolipin (MLCL). This reaction is inferred from rats. PLA2G6 has also been characterized in humans (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999).", "cellular_location": "mitochondrial inner membrane, mitochondrial matrix", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60733-1" ], "evidence": [ { "id": "R-HSA-1482778", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482778" } ] }, { "id": "R-HSA-1482856", "name": "PC is hydrolyzed to 1-acyl LPC by PLA2[5]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010, Clarke et al. 1991, Sharp et al. 1994, Song et al. 1999, Chiba et al. 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53816-1", "Q6P4A8-1", "O60733-1", "P0C869-1", "Q86XP0-1", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482856", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482856" } ] }, { "id": "R-HSA-1482884", "name": "PE is hydrolyzed to 1-acyl LPE by PLA2[2]", "equation": "", "summary": "At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 to form 1-acyl lysophosphatidylethanolamine (LPE). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G(4A/B/D/E/F) (Ghosh et al. 2006, Yamashita et al. 2009, Yamashita et al. 1999, Ghomashchi et al. 2010), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P53816-1", "Q6P4A8-1", "O60733-1", "P0C869-1", "Q86XP0-1", "Q3MJ16-3", "Q68DD2-1" ], "evidence": [ { "id": "R-HSA-1482884", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1482884" } ] }, { "id": "R-HSA-2029475", "name": "Production of AA by iPLA2 upon FCGR activation", "equation": "", "summary": "Several members of phospholipase A (PLA) are involved in phagocytosis. Macrophages express three classes of PLA2: secreted Ca-dependent (sPLA2), cytosolic Ca-dependent (cPLA2) and cytosolic Ca-independent (iPLA2) of which iPLA2 is involved in FCGR mediated arachidonic acid (AA) production. Aggregation of FCGR triggers phosphorylation and membrane translocation of iPLA2. Protein kinase C (PKC), ERK and p38MAPK seems to regulate iPLA2 in monocytes, neutrophils and macrophages. Phosphorylated iPLA2 then mediates production of AA and lysoophospholipids from phosphatidylcholine. iPLA2 inhibitors (bromoenol lactone) block AA release and phagocytosis which can be restored upon addition of exogenous AA, suggesting a critical role for iPLA2 in FCGR phagocytosis (Lennartz et al. 1993, Tay & Melendez). Release of AA by activated iPLA2 changes the physical characteristic of the membrane which may facilitate pseudopod extension.", "cellular_location": "plasma membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-428981" ], "enzyme_list": [ "O60733-1" ], "evidence": [ { "id": "R-HSA-2029475", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2029475" } ] }, { "id": "R-HSA-8848484", "name": "PLA2s hydrolyze phospholipids at the Golgi membrane", "equation": "", "summary": "Phospholipase A (PLA2) hydrolyzes the sn-2 position of phospholipids, releasing a fatty acid and a lysophospholipid (reviewed in Six and Dennis, 2000; Kudo and Murakami, 2002). A number studies have highlighted roles for a number of PLA2s in the maintenance of Golgi function and structure (de Figueiredo et al, 1998; de Figueiredo et al, 1999). PLAs may generate phospholipid and fatty acid products that recruit effectors of Golgi function and trafficking to the membrane or that affect downstream signaling pathways. Alternately, PLA2s may contribute directly to tubule formation at the Golgi through the production of the membrane-curvature inducing lysophospholipid (reviewed in Bechler et al, 2012). PLA2s may be recruited to the Golgi in response to changes in Ca2+ and/or cargo concentration that occur as a result of secretory traffic (Micaroni et al, 2010; San Pietro et al, 2009; Pulvirenti et al, 2008).", "cellular_location": "Golgi membrane", "input_participant_list": [], "output_participant_list": [ "R-ALL-6814303" ], "enzyme_list": [ "P68402-1", "O60733-1", "Q15102-1" ], "evidence": [ { "id": "R-HSA-8848484", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8848484" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-428981", "participant_name": "LPC [endoplasmic reticulum membrane]", "crossref": [ { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" }, { "id": "17504", "database": "ChEBI", "url": "" }, { "id": "C04230", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-6814303", "participant_name": "fatty acid [cytosol]", "crossref": [ { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" }, { "id": "35366", "database": "ChEBI", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0JNU3", "gene_name": "Aspg", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "A0JNU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0JNU3" } ] } ] }, { "uniprot_ac": "A2AJ88", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "A2AJ88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AJ88" } ] } ] }, { "uniprot_ac": "A6JJ35", "gene_name": "Pla2g7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "A6JJ35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6JJ35" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "A6JJ35", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6JJ35" } ] } ] }, { "uniprot_ac": "D2KX21", "gene_name": "Plaat1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "D2KX21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D2KX21" } ] } ] }, { "uniprot_ac": "D3Z9B7", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3Z9B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3Z9B7" } ] } ] }, { "uniprot_ac": "D3ZLB5", "gene_name": "Pla2g2f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3ZLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLB5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3ZLB5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZLB5" } ] } ] }, { "uniprot_ac": "D3ZQH6", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D3ZQH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQH6" } ] } ] }, { "uniprot_ac": "D3ZRC4", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "D3ZRC4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZRC4" } ] } ] }, { "uniprot_ac": "D4A1I6", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "D4A1I6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A1I6" } ] } ] }, { "uniprot_ac": "D4A328", "gene_name": "LOC120099997", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "D4A328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A328" } ] } ] }, { "uniprot_ac": "F1LPY6", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F1LPY6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LPY6" } ] } ] }, { "uniprot_ac": "F7F420", "gene_name": "Pla2g2d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "F7F420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F420" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "F7F420", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7F420" } ] } ] }, { "uniprot_ac": "O00154", "gene_name": "ACOT7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O00154", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00154" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O00154", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00154" } ] } ] }, { "uniprot_ac": "O08709", "gene_name": "Prdx6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O08709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08709" } ] } ] }, { "uniprot_ac": "O14734", "gene_name": "ACOT8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "O14734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14734" } ] } ] }, { "uniprot_ac": "O15496", "gene_name": "PLA2G10", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O15496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15496" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O15496", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15496" } ] } ] }, { "uniprot_ac": "O35244", "gene_name": "Prdx6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "O35244", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35244" } ] } ] }, { "uniprot_ac": "O35263", "gene_name": "Pafah1b3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O35263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35263" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "O35263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35263" } ] } ] }, { "uniprot_ac": "O35264", "gene_name": "Pafah1b2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O35264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35264" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "O35264", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35264" } ] } ] }, { "uniprot_ac": "O54728", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O54728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54728" } ] } ] }, { "uniprot_ac": "O55137", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55137" } ] } ] }, { "uniprot_ac": "O55171", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "O55171", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55171" } ] } ] }, { "uniprot_ac": "O60733", "gene_name": "PLA2G6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O60733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60733" } ] } ] }, { "uniprot_ac": "O75608", "gene_name": "LYPLA1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O75608", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75608" } ] } ] }, { "uniprot_ac": "O88202", "gene_name": "Aspg", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "O88202", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88202" } ] } ] }, { "uniprot_ac": "O88267", "gene_name": "Acot1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "O88267", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88267" } ] } ] }, { "uniprot_ac": "O95372", "gene_name": "LYPLA2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "O95372", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95372" } ] } ] }, { "uniprot_ac": "P04054", "gene_name": "PLA2G1B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04054", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04054" } ] } ] }, { "uniprot_ac": "P04055", "gene_name": "Pla2g1b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P04055", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04055" } ] } ] }, { "uniprot_ac": "P04180", "gene_name": "LCAT", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P04180", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04180" } ] } ] }, { "uniprot_ac": "P07867", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P07867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07867" } ] } ] }, { "uniprot_ac": "P07882", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P07882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07882" } ] } ] }, { "uniprot_ac": "P08635", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "P08635", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08635" } ] } ] }, { "uniprot_ac": "P0C548", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P0C548", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C548" } ] } ] }, { "uniprot_ac": "P0C869", "gene_name": "PLA2G4B", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C869", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C869" } ] } ] }, { "uniprot_ac": "P0C871", "gene_name": "Pla2g4b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P0C871", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C871" } ] } ] }, { "uniprot_ac": "P11150", "gene_name": "LIPC", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P11150", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11150" } ] } ] }, { "uniprot_ac": "P13437", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P13437", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13437" } ] } ] }, { "uniprot_ac": "P14423", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14423", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14423" } ] } ] }, { "uniprot_ac": "P14555", "gene_name": "PLA2G2A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P14555", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14555" } ] } ] }, { "uniprot_ac": "P16301", "gene_name": "Lcat", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P16301", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16301" } ] } ] }, { "uniprot_ac": "P18424", "gene_name": "Lcat", "activity": [ { "ec_number": "2.3.1.43", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + a sterol = a 1-acyl-sn-glycero-3-phosphocholine + a sterol ester.", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] }, { "ec_number": "2.3.1.43", "activity": "", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P18424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18424" } ] } ] }, { "uniprot_ac": "P19835", "gene_name": "CEL", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P19835", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19835" } ] } ] }, { "uniprot_ac": "P27656", "gene_name": "Lipc", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P27656", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27656" } ] } ] }, { "uniprot_ac": "P30041", "gene_name": "PRDX6", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] }, { "ec_number": "2.3.1.23", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA.", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "P30041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30041" } ] } ] }, { "uniprot_ac": "P31482", "gene_name": "Pla2g2a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P31482", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31482" } ] } ] }, { "uniprot_ac": "P36165", "gene_name": "TGL4", "activity": [ { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P36165", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36165" } ] } ] }, { "uniprot_ac": "P39105", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "P39105", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39105" } ] } ] }, { "uniprot_ac": "P39877", "gene_name": "PLA2G5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P39877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39877" } ] } ] }, { "uniprot_ac": "P39878", "gene_name": "Pla2g2c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P39878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39878" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P39878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39878" } ] } ] }, { "uniprot_ac": "P41247", "gene_name": "PNPLA4", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "P41247", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41247" } ] } ] }, { "uniprot_ac": "P41903", "gene_name": "TES1", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P41903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41903" } ] } ] }, { "uniprot_ac": "P42765", "gene_name": "ACAA2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "P42765", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42765" } ] } ] }, { "uniprot_ac": "P47712", "gene_name": "PLA2G4A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47712", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47712" } ] } ] }, { "uniprot_ac": "P47713", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P47713", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47713" } ] } ] }, { "uniprot_ac": "P48076", "gene_name": "Pla2g2c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P48076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48076" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P48076", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48076" } ] } ] }, { "uniprot_ac": "P49753", "gene_name": "ACOT2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P49753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49753" } ] } ] }, { "uniprot_ac": "P50393", "gene_name": "Pla2g4a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P50393", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50393" } ] } ] }, { "uniprot_ac": "P51433", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P51433", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51433" } ] } ] }, { "uniprot_ac": "P53816", "gene_name": "PLAAT3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53816", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53816" } ] } ] }, { "uniprot_ac": "P53817", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P53817", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53817" } ] } ] }, { "uniprot_ac": "P58137", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "P58137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58137" } ] } ] }, { "uniprot_ac": "P68402", "gene_name": "PAFAH1B2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P68402", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68402" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P68402", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68402" } ] } ] }, { "uniprot_ac": "P70470", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P70470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70470" } ] } ] }, { "uniprot_ac": "P80250", "gene_name": "", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "P80250", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P80250" } ] } ] }, { "uniprot_ac": "P83006", "gene_name": "Pafah2", "activity": [ { "ec_number": "2.3.1.149", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid.", "evidence": [ { "id": "P83006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83006" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "P83006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83006" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "P83006", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83006" } ] } ] }, { "uniprot_ac": "P97391", "gene_name": "Pla2g5", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97391", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97391" } ] } ] }, { "uniprot_ac": "P97570", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97570" } ] } ] }, { "uniprot_ac": "P97819", "gene_name": "Pla2g6", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "P97819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97819" } ] } ] }, { "uniprot_ac": "P97823", "gene_name": "Lypla1", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "P97823", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97823" } ] } ] }, { "uniprot_ac": "Q03674", "gene_name": "PLB2", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q03674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03674" } ] } ] }, { "uniprot_ac": "Q04958", "gene_name": "NTE1", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q04958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04958" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q04958", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04958" } ] } ] }, { "uniprot_ac": "Q08108", "gene_name": "PLB3", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q08108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08108" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q08108", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08108" } ] } ] }, { "uniprot_ac": "Q08448", "gene_name": "LPL1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q08448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08448" } ] }, { "ec_number": "3.1.-.-", "activity": "", "evidence": [ { "id": "Q08448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08448" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q08448", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08448" } ] } ] }, { "uniprot_ac": "Q13093", "gene_name": "PLA2G7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q13093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13093" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q13093", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13093" } ] } ] }, { "uniprot_ac": "Q14032", "gene_name": "BAAT", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q14032", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14032" } ] } ] }, { "uniprot_ac": "Q15102", "gene_name": "PAFAH1B3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q15102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15102" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q15102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15102" } ] } ] }, { "uniprot_ac": "Q3MJ16", "gene_name": "PLA2G4E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q3MJ16", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3MJ16" } ] } ] }, { "uniprot_ac": "Q3TRM4", "gene_name": "Pnpla6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TRM4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TRM4" } ] } ] }, { "uniprot_ac": "Q3TTY0", "gene_name": "Plb1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q3TTY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3TTY0" } ] } ] }, { "uniprot_ac": "Q3UUI3", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q3UUI3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UUI3" } ] } ] }, { "uniprot_ac": "Q4KLN5", "gene_name": "Plaat5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q4KLN5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLN5" } ] } ] }, { "uniprot_ac": "Q50L41", "gene_name": "Pla2g4f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L41" } ] } ] }, { "uniprot_ac": "Q50L42", "gene_name": "Pla2g4e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L42" } ] } ] }, { "uniprot_ac": "Q50L43", "gene_name": "Pla2g4d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q50L43", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q50L43" } ] } ] }, { "uniprot_ac": "Q566R0", "gene_name": "Them4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q566R0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q566R0" } ] } ] }, { "uniprot_ac": "Q5BK26", "gene_name": "Pnpla7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q5BK26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5BK26" } ] } ] }, { "uniprot_ac": "Q5R387", "gene_name": "PLA2G2C", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q5R387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5R387" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q5R387", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5R387" } ] } ] }, { "uniprot_ac": "Q5T1C6", "gene_name": "THEM4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q5T1C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T1C6" } ] } ] }, { "uniprot_ac": "Q60963", "gene_name": "Pla2g7", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q60963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60963" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q60963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60963" } ] } ] }, { "uniprot_ac": "Q61205", "gene_name": "Pafah1b3", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q61205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61205" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q61205", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61205" } ] } ] }, { "uniprot_ac": "Q61206", "gene_name": "Pafah1b2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q61206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61206" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q61206", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61206" } ] } ] }, { "uniprot_ac": "Q63276", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q63276", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63276" } ] } ] }, { "uniprot_ac": "Q64285", "gene_name": "Cel", "activity": [ { "ec_number": "3.1.1.13", "activity": "a cholesterol ester + H2O = a fatty acid + cholesterol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+).", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.13", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.6", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q64285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64285" } ] } ] }, { "uniprot_ac": "Q64559", "gene_name": "Acot7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q64559", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64559" } ] } ] }, { "uniprot_ac": "Q64GA5", "gene_name": "Pla2g4c", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q64GA5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64GA5" } ] } ] }, { "uniprot_ac": "Q675A5", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q675A5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q675A5" } ] } ] }, { "uniprot_ac": "Q68D91", "gene_name": "MBLAC2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q68D91", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68D91" } ] } ] }, { "uniprot_ac": "Q68DD2", "gene_name": "PLA2G4F", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q68DD2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q68DD2" } ] } ] }, { "uniprot_ac": "Q6P1J6", "gene_name": "PLB1", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q6P1J6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P1J6" } ] } ] }, { "uniprot_ac": "Q6P4A8", "gene_name": "PLBD1", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q6P4A8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P4A8" } ] } ] }, { "uniprot_ac": "Q6Q2Z6", "gene_name": "Acot5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6Q2Z6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q2Z6" } ] } ] }, { "uniprot_ac": "Q6ZUV0", "gene_name": "ACOT7L", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q6ZUV0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZUV0" } ] } ] }, { "uniprot_ac": "Q6ZV29", "gene_name": "PNPLA7", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q6ZV29", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZV29" } ] } ] }, { "uniprot_ac": "Q7KUD4", "gene_name": "iPLA2-VIA", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q7KUD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KUD4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q7KUD4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KUD4" } ] } ] }, { "uniprot_ac": "Q7L5L3", "gene_name": "GDPD3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q7L5L3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7L5L3" } ] } ] }, { "uniprot_ac": "Q86TX2", "gene_name": "ACOT1", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q86TX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86TX2" } ] } ] }, { "uniprot_ac": "Q86U10", "gene_name": "ASPG", "activity": [ { "ec_number": "3.5.1.1", "activity": "H2O + L-asparagine = L-aspartate + NH4(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] }, { "ec_number": "3.5.1.1", "activity": "", "evidence": [ { "id": "Q86U10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86U10" } ] } ] }, { "uniprot_ac": "Q86XP0", "gene_name": "PLA2G4D", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q86XP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XP0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q86XP0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XP0" } ] } ] }, { "uniprot_ac": "Q8BG37", "gene_name": "Prdx6b", "activity": [ { "ec_number": "1.11.1.27", "activity": "a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O.", "evidence": [ { "id": "Q8BG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG37" } ] }, { "ec_number": "1.11.1.27", "activity": "", "evidence": [ { "id": "Q8BG37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BG37" } ] } ] }, { "uniprot_ac": "Q8BJ56", "gene_name": "Pnpla2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q8BJ56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BJ56" } ] } ] }, { "uniprot_ac": "Q8BL86", "gene_name": "Mblac2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.5.2.6", "activity": "a beta-lactam + H2O = a substituted beta-amino acid.", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8BL86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BL86" } ] } ] }, { "uniprot_ac": "Q8BWT1", "gene_name": "Acaa2", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.9", "activity": "2 acetyl-CoA = acetoacetyl-CoA + CoA.", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] }, { "ec_number": "2.3.1.16", "activity": "", "evidence": [ { "id": "Q8BWT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BWT1" } ] } ] }, { "uniprot_ac": "Q8BZT7", "gene_name": "Pla2g3", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8BZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZT7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8BZT7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BZT7" } ] } ] }, { "uniprot_ac": "Q8IML0", "gene_name": "Dmel\\CG14507", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8IML0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IML0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8IML0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IML0" } ] } ] }, { "uniprot_ac": "Q8IY17", "gene_name": "PNPLA6", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8IY17", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IY17" } ] } ] }, { "uniprot_ac": "Q8K1N1", "gene_name": "Pnpla8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8K1N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K1N1" } ] } ] }, { "uniprot_ac": "Q8N1Q8", "gene_name": "THEM5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8N1Q8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N1Q8" } ] } ] }, { "uniprot_ac": "Q8N9L9", "gene_name": "ACOT4", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8N9L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N9L9" } ] } ] }, { "uniprot_ac": "Q8NCC3", "gene_name": "PLA2G15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8NCC3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NCC3" } ] } ] }, { "uniprot_ac": "Q8R197", "gene_name": "Olah", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "Q8R197", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R197" } ] } ] }, { "uniprot_ac": "Q8R3U1", "gene_name": "Plaat3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8R3U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R3U1" } ] } ] }, { "uniprot_ac": "Q8VDG7", "gene_name": "Pafah2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q8VDG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDG7" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q8VDG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDG7" } ] }, { "ec_number": "2.3.1.149", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid.", "evidence": [ { "id": "Q8VDG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VDG7" } ] } ] }, { "uniprot_ac": "Q8VEB4", "gene_name": "Pla2g15", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8VEB4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VEB4" } ] } ] }, { "uniprot_ac": "Q8VHK0", "gene_name": "Acot8", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "acetyl-CoA + H2O = acetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "H2O + succinyl-CoA = CoA + H(+) + succinate.", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.11", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.5", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.3", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] }, { "ec_number": "3.1.2.1", "activity": "", "evidence": [ { "id": "Q8VHK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHK0" } ] } ] }, { "uniprot_ac": "Q8VHQ9", "gene_name": "Acot11", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8VHQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHQ9" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8VHQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VHQ9" } ] } ] }, { "uniprot_ac": "Q8WU67", "gene_name": "ABHD3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q8WU67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WU67" } ] } ] }, { "uniprot_ac": "Q8WXI4", "gene_name": "ACOT11", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q8WXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXI4" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q8WXI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WXI4" } ] } ] }, { "uniprot_ac": "Q91V12", "gene_name": "Acot7", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q91V12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V12" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q91V12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91V12" } ] } ] }, { "uniprot_ac": "Q91WW7", "gene_name": "Pnpla3", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "Q91WW7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WW7" } ] } ] }, { "uniprot_ac": "Q91X34", "gene_name": "Baat", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] }, { "ec_number": "3.1.2.27", "activity": "(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+).", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] }, { "ec_number": "2.3.1.65", "activity": "choloyl-CoA + glycine = CoA + glycocholate + H(+).", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] }, { "ec_number": "2.3.1.65", "activity": "", "evidence": [ { "id": "Q91X34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91X34" } ] } ] }, { "uniprot_ac": "Q91ZH7", "gene_name": "Abhd3", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q91ZH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZH7" } ] } ] }, { "uniprot_ac": "Q96AD5", "gene_name": "PNPLA2", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q96AD5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AD5" } ] } ] }, { "uniprot_ac": "Q96KN8", "gene_name": "PLAAT5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q96KN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96KN8" } ] } ] }, { "uniprot_ac": "Q99487", "gene_name": "PAFAH2", "activity": [ { "ec_number": "3.1.1.47", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+).", "evidence": [ { "id": "Q99487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99487" } ] }, { "ec_number": "3.1.1.47", "activity": "", "evidence": [ { "id": "Q99487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99487" } ] }, { "ec_number": "2.3.1.149", "activity": "a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-organyl-2-lyso-sn-glycero-3-phospholipid = 1-O-alkyl-sn-glycero-3-phosphocholine + a 1-organyl-2-acetyl-sn-glycero-3-phospholipid.", "evidence": [ { "id": "Q99487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99487" } ] } ] }, { "uniprot_ac": "Q99LY2", "gene_name": "Gdpd3", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q99LY2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99LY2" } ] } ] }, { "uniprot_ac": "Q9BZM1", "gene_name": "PLA2G12A", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9BZM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM1" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9BZM1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM1" } ] } ] }, { "uniprot_ac": "Q9BZM2", "gene_name": "PLA2G2F", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9BZM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9BZM2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BZM2" } ] } ] }, { "uniprot_ac": "Q9CPX5", "gene_name": "Plaat5", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9CPX5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CPX5" } ] } ] }, { "uniprot_ac": "Q9CQJ0", "gene_name": "Them5", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9CQJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQJ0" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q9CQJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQJ0" } ] } ] }, { "uniprot_ac": "Q9CQR4", "gene_name": "Acot13", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9CQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQR4" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9CQR4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQR4" } ] } ] }, { "uniprot_ac": "Q9EPR2", "gene_name": "Pla2g12a", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9EPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPR2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9EPR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EPR2" } ] } ] }, { "uniprot_ac": "Q9ESN3", "gene_name": "Pgap6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9ESN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9ESN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESN3" } ] } ] }, { "uniprot_ac": "Q9HCN3", "gene_name": "PGAP6", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCN3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9HCN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCN3" } ] } ] }, { "uniprot_ac": "Q9HDD0", "gene_name": "PLAAT1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9HDD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HDD0" } ] } ] }, { "uniprot_ac": "Q9NP80", "gene_name": "PNPLA8", "activity": [ { "ec_number": "3.1.1.-", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q9NP80", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP80" } ] } ] }, { "uniprot_ac": "Q9NPJ3", "gene_name": "ACOT13", "activity": [ { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9NPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NPJ3" } ] }, { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9NPJ3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NPJ3" } ] } ] }, { "uniprot_ac": "Q9NST1", "gene_name": "PNPLA3", "activity": [ { "ec_number": "2.3.1.51", "activity": "a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA.", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] }, { "ec_number": "2.3.1.51", "activity": "", "evidence": [ { "id": "Q9NST1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NST1" } ] } ] }, { "uniprot_ac": "Q9NV23", "gene_name": "OLAH", "activity": [ { "ec_number": "3.1.2.14", "activity": "(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + H(+) + holo-[ACP].", "evidence": [ { "id": "Q9NV23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV23" } ] }, { "ec_number": "3.1.2.14", "activity": "", "evidence": [ { "id": "Q9NV23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV23" } ] } ] }, { "uniprot_ac": "Q9NWW9", "gene_name": "PLAAT2", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9NWW9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NWW9" } ] } ] }, { "uniprot_ac": "Q9NZ20", "gene_name": "PLA2G3", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NZ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ20" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NZ20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZ20" } ] } ] }, { "uniprot_ac": "Q9NZK7", "gene_name": "PLA2G2E", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9NZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZK7" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9NZK7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NZK7" } ] } ] }, { "uniprot_ac": "Q9QUL3", "gene_name": "Pla2g2e", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QUL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUL3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QUL3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QUL3" } ] } ] }, { "uniprot_ac": "Q9QXX3", "gene_name": "Pla2g10", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QXX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXX3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QXX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXX3" } ] } ] }, { "uniprot_ac": "Q9QYL8", "gene_name": "Lypla2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] }, { "ec_number": "3.1.2.22", "activity": "", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9QYL8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYL8" } ] } ] }, { "uniprot_ac": "Q9QYR7", "gene_name": "Acot3", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9QYR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR7" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q9QYR7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR7" } ] } ] }, { "uniprot_ac": "Q9QYR9", "gene_name": "Acot2", "activity": [ { "ec_number": "3.1.2.2", "activity": "H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate.", "evidence": [ { "id": "Q9QYR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR9" } ] }, { "ec_number": "3.1.2.2", "activity": "", "evidence": [ { "id": "Q9QYR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYR9" } ] } ] }, { "uniprot_ac": "Q9QZT3", "gene_name": "Pla2g10", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT3" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QZT3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT3" } ] } ] }, { "uniprot_ac": "Q9QZT4", "gene_name": "Pla2g2f", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QZT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZT4" } ] } ] }, { "uniprot_ac": "Q9QZU4", "gene_name": "Plaat1", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9QZU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QZU4" } ] } ] }, { "uniprot_ac": "Q9U969", "gene_name": "sws", "activity": [ { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9U969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9U969" } ] } ] }, { "uniprot_ac": "Q9UL19", "gene_name": "PLAAT4", "activity": [ { "ec_number": "3.1.1.32", "activity": "a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] }, { "ec_number": "3.1.1.32", "activity": "", "evidence": [ { "id": "Q9UL19", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UL19" } ] } ] }, { "uniprot_ac": "Q9UNK4", "gene_name": "PLA2G2D", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UNK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNK4" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UNK4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNK4" } ] } ] }, { "uniprot_ac": "Q9UP65", "gene_name": "PLA2G4C", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9UP65", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UP65" } ] } ] }, { "uniprot_ac": "Q9VMM8", "gene_name": "Dmel\\CG11029", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.3", "activity": "a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+).", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.5", "activity": "a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine.", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.3", "activity": "", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] }, { "ec_number": "3.1.1.5", "activity": "", "evidence": [ { "id": "Q9VMM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VMM8" } ] } ] }, { "uniprot_ac": "Q9WTL7", "gene_name": "Lypla2", "activity": [ { "ec_number": "3.1.2.22", "activity": "H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) + hexadecanoate + L-cysteinyl-[protein].", "evidence": [ { "id": "Q9WTL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTL7" } ] }, { "ec_number": "3.1.2.-", "activity": "", "evidence": [ { "id": "Q9WTL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WTL7" } ] } ] }, { "uniprot_ac": "Q9WVF6", "gene_name": "Pla2g2d", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9WVF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVF6" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9WVF6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVF6" } ] } ] }, { "uniprot_ac": "Q9Z0Y2", "gene_name": "Pla2g1b", "activity": [ { "ec_number": "3.1.1.4", "activity": "1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+).", "evidence": [ { "id": "Q9Z0Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z0Y2" } ] }, { "ec_number": "3.1.1.4", "activity": "", "evidence": [ { "id": "Q9Z0Y2", 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