{ "uniprot_canonical_ac": "O60725-1", "uniprot_ac": "O60725", "uniprot_id": "ICMT_HUMAN", "mass": { "chemical_mass": 31938.0, "monoisotopic_mass": 31938.0 }, "refseq": { "ac": "NP_036537", "name": "protein-S-isoprenylcysteine O-methyltransferase", "summary": "This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" }, "gene_names": [ { "name": "ICMT", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60725", "id": "O60725" }, { "name": "HSTE14; MST098; MSTP098; PCCMT; PCMT; PPMT", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537", "id": "NP_036537" }, { "name": "ICMT", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537", "id": "NP_036537" }, { "name": "PCCMT", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60725", "id": "O60725" } ], "protein_names": [ { "name": "Protein-S-isoprenylcysteine O-methyltransferase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60725" }, { "name": "2.1.1.100", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60725" }, { "name": "Isoprenylcysteine carboxylmethyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60725" }, { "name": "PPMT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60725" }, { "name": "Prenylated protein carboxyl methyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60725" }, { "name": "Prenylcysteine carboxyl methyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60725" }, { "name": "pcCMT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60725" }, { "name": "prenylcysteine carboxyl methyltransferase; prenylated protein carboxyl methyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537", "id": "NP_036537" }, { "name": "protein-S-isoprenylcysteine O-methyltransferase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537", "id": "NP_036537" } ], "function": [ { "annotation": "Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725#function" }, { "database": "PubMed", "id": "9614111", "url": "https://glygen.org/publication/PubMed/9614111" } ] }, { "annotation": "CircRNA hsa_circ_0018289 exerts an oncogenic role in cervical cancer progression through miR-1294/ICMT axis.", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" }, { "database": "PubMed", "id": "35312113", "url": "https://glygen.org/publication/PubMed/35312113" } ] }, { "annotation": "ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" }, { "database": "PubMed", "id": "12006387", "url": "https://glygen.org/publication/PubMed/12006387" } ] }, { "annotation": "Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal.", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" }, { "database": "PubMed", "id": "32561852", "url": "https://glygen.org/publication/PubMed/32561852" } ] }, { "annotation": "Modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma cells", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" }, { "database": "PubMed", "id": "11906819", "url": "https://glygen.org/publication/PubMed/11906819" } ] }, { "annotation": "NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" }, { "database": "PubMed", "id": "33579760", "url": "https://glygen.org/publication/PubMed/33579760" } ] }, { "annotation": "PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" }, { "database": "PubMed", "id": "35914811", "url": "https://glygen.org/publication/PubMed/35914811" } ] }, { "annotation": "This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "89.52", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "87.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "92.41", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "73.48", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "89.77", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "92.1", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "91.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "89.1", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "86.13", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "87.25", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "85.2", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "85.76", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "86.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000116237", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000116237" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60725", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60725" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O60725", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60725" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O60725", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60725" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O60725", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60725" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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"https://www.ensembl.org/id/ENSP00000343552.5" } ] } }, { "isoform_ac": "Q7Z750-1", "url": "", "sequence": { "sequence": "MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWSHLVHPHSHCRIFPYTMISVP", "length": 116, "header": "tr|Q7Z750-1|Q7Z750_HUMAN Computationally mapped isoform of Isoprenylcysteine carboxyl methyltransferase OS=Homo sapiens OX=9606 GN=ICMT PE=1 SV=1 CANONICAL=O60725-1" }, "locus": { "chromosome": "1", "start_pos": 6235911, "end_pos": 6234448, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000489498.5", "url": "https://www.ensembl.org/id/ENST00000489498.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000466222.1", "url": "https://www.ensembl.org/id/ENSP00000466222.1" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Cloning and characterization of a mammalian prenyl protein-specific protease.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Otto JC, Kim E, Young SG, Casey PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "10085068", "url": "https://glygen.org/publication/PubMed/10085068" } ] }, { "title": "Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ, Young SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "10085069", "url": "https://glygen.org/publication/PubMed/10085069" } ] }, { "title": "Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1.", "journal": "Nat. Neurosci.", "date": "2000", "authors": "Lin X, Antalffy B, Kang D, Orr HT, Zoghbi HY", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "reference": [ { "type": "PubMed", "id": "10649571", "url": "https://glygen.org/publication/PubMed/10649571" } ] }, { "title": "Selective inhibition of ras-transformed cell growth by a novel fatty acid-based chloromethyl ketone designed to target Ras endoprotease.", "journal": "Annals of the New York Academy of Sciences", "date": "1999", "authors": "Chen Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "10667208", "url": "https://glygen.org/publication/PubMed/10667208" } ] }, { "title": "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.", "journal": "Diabetes", "date": "2000", "authors": "Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E", "evidence": [ { "database": "Reactome", "id": "R-HSA-163841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163841" } ], "reference": [ { "type": "PubMed", "id": "11016445", "url": "https://glygen.org/publication/PubMed/11016445" } ] }, { "title": "Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides.", "journal": "Analytical biochemistry", "date": "2000", "authors": "Hollander I, Frommer E, Mallon R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "11038283", "url": "https://glygen.org/publication/PubMed/11038283" } ] }, { "title": "The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines.", "journal": "Experimental cell research", "date": "2001", "authors": "Ashar HR, James L, Gray K, Carr D, McGuirk M, Maxwell E, Black S, Armstrong L, Doll RJ, Taveras AG, Bishop WR, Kirschmeier P", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "11120601", "url": "https://glygen.org/publication/PubMed/11120601" } ] }, { "title": "Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.", "journal": "Cancer research", "date": "2001", "authors": "End DW, Smets G, Todd AV, Applegate TL, Fuery CJ, Angibaud P, Venet M, Sanz G, Poignet H, Skrzat S, Devine A, Wouters W, Bowden C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "11196150", "url": "https://glygen.org/publication/PubMed/11196150" } ] }, { "title": "Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling.", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Villalonga P, Lopez-Alcala C, Bosch M, Chiloeches A, Rocamora N, Gil J, Marais R, Marshall CJ, Bachs O, Agell N", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "11585916", "url": "https://glygen.org/publication/PubMed/11585916" } ] }, { "title": "Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, Balmain A, Young SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "11739732", "url": "https://glygen.org/publication/PubMed/11739732" } ] }, { "title": "Prenylcysteine carboxymethyltransferase type III activity is decreased in retinoic acid-treated SH-SY5Y neuroblastoma cells.", "journal": "The international journal of biochemistry & cell biology", "date": "2002", "authors": "Van Dessel GA, De Busser HM, Lagrou AR", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" } ], "reference": [ { "type": "PubMed", "id": "11906819", "url": "https://glygen.org/publication/PubMed/11906819" } ] }, { "title": "Role of isoprenylcysteine carboxyl methyltransferase in tumor necrosis factor-alpha stimulation of expression of vascular cell adhesion molecule-1 in endothelial cells.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2002", "authors": "Ahmad M, Zhang Y, Zhang Y, Papharalambus C, Alexander RW", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" } ], "reference": [ { "type": "PubMed", "id": "12006387", "url": "https://glygen.org/publication/PubMed/12006387" } ] }, { "title": "Hematologic effects of inactivating the Ras processing enzyme Rce1.", "journal": "Blood", "date": "2003", "authors": "Aiyagari AL, Taylor BR, Aurora V, Young SG, Shannon KM", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "12433685", "url": "https://glygen.org/publication/PubMed/12433685" } ] }, { "title": "Ca2+/calmodulin binds and dissociates K-RasB from membrane.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Sidhu RS, Clough RR, Bhullar RP", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "12727204", "url": "https://glygen.org/publication/PubMed/12727204" } ] }, { "title": "Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2003", "authors": "Winter-Vann AM, Kamen BA, Bergo MO, Young SG, Melnyk S, James SJ, Casey PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "12750467", "url": "https://glygen.org/publication/PubMed/12750467" } ] }, { "title": "Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Zhang H, Liu XH, Zhang K, Chen CK, Frederick JM, Prestwich GD, Baehr W", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "14561760", "url": "https://glygen.org/publication/PubMed/14561760" } ] }, { "title": "A mammalian protein homologous to fructosamine-3-kinase is a ketosamine-3-kinase acting on psicosamines and ribulosamines but not on fructosamines.", "journal": "Diabetes", "date": "2003", "authors": "Collard F, Delpierre G, Stroobant V, Matthijs G, Van Schaftingen E", "evidence": [ { "database": "Reactome", "id": "R-HSA-163841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163841" } ], "reference": [ { "type": "PubMed", "id": "14633848", "url": "https://glygen.org/publication/PubMed/14633848" } ] }, { "title": "Carboxyl methylation of Ras regulates membrane targeting and effector engagement.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Chiu VK, Silletti J, Dinsell V, Wiener H, Loukeris K, Ou G, Philips MR, Pillinger MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "14660603", "url": "https://glygen.org/publication/PubMed/14660603" } ] }, { "title": "Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.", "journal": "The Journal of clinical investigation", "date": "2004", "authors": "Bergo MO, Gavino BJ, Hong C, Beigneux AP, McMahon M, Casey PJ, Young SG", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "14966563", "url": "https://glygen.org/publication/PubMed/14966563" } ] }, { "title": "Identification of fructosamine residues deglycated by fructosamine-3-kinase in human hemoglobin.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Delpierrre G, Vertommen D, Communi D, Rider MH, Van Schaftingen E", "evidence": [ { "database": "Reactome", "id": "R-HSA-163841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163841" } ], "reference": [ { 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"2021", "authors": "Ahearn IM, Court HR, Siddiqui F, Abankwa D, Philips MR", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" } ], "reference": [ { "type": "PubMed", "id": "33579760", "url": "https://glygen.org/publication/PubMed/33579760" } ] }, { "title": "CircRNA hsa_circ_0018289 exerts an oncogenic role in cervical cancer progression through miR-1294/ICMT axis.", "journal": "Journal of clinical laboratory analysis", "date": "2022", "authors": "Li Y, Gao X, Yang C, Yan H, Li C", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" } ], "reference": [ { "type": "PubMed", "id": "35312113", "url": "https://glygen.org/publication/PubMed/35312113" } ] }, { "title": "PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma.", "journal": "Life science alliance", "date": "2022", "authors": "Sittewelle M, Kappes V, Zhou C, Lecuyer D, Monsoro-Burq AH", "evidence": [ { "database": "RefSeq", "id": "NP_036537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036537" } ], "reference": [ { "type": "PubMed", "id": "35914811", "url": "https://glygen.org/publication/PubMed/35914811" } ] }, { "title": "Identification of individual tyrosine sulfation sites within factor VIII required for optimal activity and efficient thrombin cleavage.", "journal": "The Journal of biological chemistry", "date": "1994", "authors": "Michnick DA, Pittman DD, Wise RJ, Kaufman RJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-163841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163841" } ], "reference": [ { "type": "PubMed", "id": "8051097", "url": "https://glygen.org/publication/PubMed/8051097" } ] }, { "title": "Establishment of a human pancreatic tumor xenograft model: potential application for preclinical evaluation of novel therapeutic agents.", "journal": "Pancreas", "date": "1998", "authors": "Mohammad RM, Dugan MC, Mohamed AN, Almatchy VP, Flake TM, Dergham ST, Shields AF, Al-Katib AA, Vaitkevicius VK, Sarkar FH", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "9436858", "url": "https://glygen.org/publication/PubMed/9436858" } ] }, { "title": "Tyrosylprotein sulfotransferase: purification and molecular cloning of an enzyme that catalyzes tyrosine O-sulfation, a common posttranslational modification of eukaryotic proteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Ouyang Yb, Lane WS, Moore KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-163841", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163841" } ], "reference": [ { "type": "PubMed", "id": "9501187", "url": "https://glygen.org/publication/PubMed/9501187" } ] }, { "title": "Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum.", "journal": "The Journal of biological chemistry", "date": "1998-06-12", "authors": "Dai Q, Choy E, Chiu V, Romano J, Slivka S R, Steitz S A, Michaelis S, Philips M R", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "reference": [ { "type": "PubMed", "id": "9614111", "url": "https://glygen.org/publication/PubMed/9614111" } ] }, { "title": "Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.", "journal": "Cancer research", "date": "1998", "authors": "Liu M, Bryant MS, Chen J, Lee S, Yaremko B, Lipari P, Malkowski M, Ferrari E, Nielsen L, Prioli N, Dell J, Sinha D, Syed J, Korfmacher WA, Nomeir AA, Lin CC, Wang L, Taveras AG, Doll RJ, Njoroge FG, Mallams AK, Remiszewski S, Catino JJ, Girijavallabhan VM, Bishop WR, et al.", "evidence": [ { "database": 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"id": "9822558", "url": "https://glygen.org/publication/PubMed/9822558" } ] }, { "title": "Inhibition of K-ras-transformed rodent and human cancer cell growth via induction of apoptosis by irreversible inhibitors of Ras endoprotease.", "journal": "Cancer letters", "date": "1998", "authors": "Chen Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9648002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002" } ], "reference": [ { "type": "PubMed", "id": "9851253", "url": "https://glygen.org/publication/PubMed/9851253" } ] } ], "pathway": [ { "id": "hsa:23463", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23463", "resource": "KEGG Pathway" }, { "id": "R-HSA-163841", "name": "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-163841", "resource": "Reactome", "description": "Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation" }, { "id": "R-HSA-9648002", "name": "RAS processing", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9648002", "resource": "Reactome", "description": "RAS processing" } ], "orthologs": [ { "uniprot_canonical_ac": "Q9EQK7-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "Icmt", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAAARRGSAGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSATGLLMVVFGECLRKAAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFIKGVKVEL", "length": 283 }, "evidence": [ { "id": "45923698", "url": "http://www.informatics.jax.org/homology/45923698", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q9VU37-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "Icmt", "tax_id": 7227, "organism": "Drosophila melanogaster", "sequence": { "sequence": "MCAKSRVASPGAGGTSLCSEGRISLYCFLITAALVLIPSVPQNLYGVVPQVWGAVLWGPFLYYALINMIIRFVLRNHDYQVAIRASFLGFAMAVSVLVICFAPTEWQQFGAYGCFMSLFHYSEFLVIAFANPRTLSLDSFMLNHSVHYGLAAAASWIEFSLEVYYLPQFKRYGYIWVAGVVLCLLGEMVRKAAIITAGRSFTHLVQNEKHSEHKLITSGIYAYCRHPSYVGWFWWSIGTQIVLLNPICICIYTLVSWLFFHDRIYVEEYSLLNFFQSDYVRYQKRVPTGLPFIRGYLVD", "length": 299 }, "evidence": [ { "id": "O60725", "url": "https://omabrowser.org/oma/group/O60725/", "database": "OMA" } ], "common_name": "Fruit fly" }, { "uniprot_canonical_ac": "Q9WVM4-1", "protein_name": "Protein-S-isoprenylcysteine O-methyltransferase", "gene_name": "Icmt", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MAGCAARVPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGVLLSFSQSSWNHFGWYVCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWIEFTLENIFWPELKQITWLSAAGLLMVIFGECLRKVAMFTAGSNFNHVVQSEKSDTHTLVTSGVYAWCRHPSYVGWFYWSIGTQVMLCNPICGVVYALTVWRFFRDRTEEEEISLIHFFGEEYLDYKKRVPTGLPFIKGVKVGL", "length": 284 }, "evidence": [ { "id": "45923698", "url": "http://www.informatics.jax.org/homology/45923698", "database": "MGI" }, { "id": "O60725", "url": "https://omabrowser.org/oma/group/O60725/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "protein modification process", "id": "GO:0036211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036211", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" }, { "name": "protein targeting to membrane", "id": "GO:0006612", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" }, { "name": "S-adenosylhomocysteine metabolic process", "id": "GO:0046498", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046498", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" }, { "name": "C-terminal protein methylation", "id": "GO:0006481", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006481", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" }, { "name": "S-adenosylmethioninamine metabolic process", "id": "GO:0046499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046499", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "endoplasmic reticulum", "id": "GO:0005783", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "protein C-terminal carboxyl O-methyltransferase activity", "id": "GO:0003880", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003880", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" }, { "name": "protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity", "id": "GO:0004671", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004671", "evidence": [ { "database": "UniProtKB", "id": "O60725", "url": "https://www.uniprot.org/uniprot/O60725" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 127, "end_pos": 129, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "21672", "name": "", "equation": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9WVM4-1", "O60725-1", "Q9EQK7-1", "P32584-1", "Q558K8-1", "Q9VU37-1" ], "evidence": [ { "id": "21672", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/21672" } ] }, { "id": "R-HSA-6788650", "name": "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins", "equation": "", "summary": "Protein-S-isoprenylcysteine O-methyltransferase (ICMT) mediates the post-translational methyl esterification of C-terminal CAAX motifs in prenylated proteins such as the oncoprotein RAS and related GTPases, neutralising the negative charge of prenylcysteine species and thereby determining their subcellular localisation and correct biological function (Wright et al. 2009, Yang et al. 2011). ICMT may serve as a therapeutic target in cancer development (Lau et al. 2014, Diver et al. 2014).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [ "R-ALL-6788753" ], "output_participant_list": [ "R-ALL-6788758" ], "enzyme_list": [ "O60725-1" ], "evidence": [ { "id": "R-HSA-6788650", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6788650" } ] }, { "id": "R-HSA-9647977", "name": "ICMT methylates S-Farn RAS proteins", "equation": "", "summary": "RAS proteins undergo C-terminal carboxymethylation by isoprenylcysteine methyltransferase (ICMT) (Yang et al, 2011; Dharmaiah et al, 2016; reviewed in Gysin et al, 2011; Ahearn et al, 2018). LIke prenylation, methylation is required for plasma membrane localization and function of RAS proteins, and disruption of ICMT or interference with the methylation reaction inhibits cell growth and KRAS-dependent transformation (Chiu et al, 2004; Michaelson et al, 2005; Bergo et al, 2004; Wahlstrom et al, 2008; Winter-Vann et al, 2003). Consistent with this, a number of small molecule inhibitors of ICMT have been shown to decrease tumor proliferation (Wang et al, 2009; Manu et al, 2017; Sun et al, 2016).", "cellular_location": "endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P01111-1", "P01112-1", "O60725-1", "P01116-1" ], "evidence": [ { "id": "R-HSA-9647977", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9647977" } ] }, { "id": "R-HSA-9656775", "name": "Cysmethynil binds ICMT:Zn2+", "equation": "", "summary": "Cysmethnil is a small molecule inhibitor of ICMT that has been shown to reduce proliferation of cancer cell lines by promoting apoptosis (Winter-Vann et al, 2005; Wang et al, 2010; Judd et al, 2011; Sun et al, 2016; Manu et al, 2017). Cysmethynil is a poor candidate for clinical trials due to low solubility and other physical characteristics. A number of related small molecule inhibitors with improved physical properties are under investigation (Lau et al, 2014; Ramanujulu et al, 2013).", "cellular_location": "cytosol, endoplasmic reticulum membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O60725-1" ], "evidence": [ { "id": "R-HSA-9656775", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9656775" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-6788753", "participant_name": "S-FARN-Cys [cytosol]", "crossref": [ { "id": "86019", "database": "ChEBI", "url": "" }, { "id": "86019", "database": "ChEBI", "url": "" }, { "id": "86019", "database": "ChEBI", "url": "" }, { "id": "86019", "database": "ChEBI", "url": "" }, { "id": "86019", "database": "ChEBI", "url": "" }, { "id": "86019", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-6788758", "participant_name": "S-FARN-CME [cytosol]", "crossref": [ { "id": "000031259909", "database": "ZINC", "url": "" }, { "id": "87167", "database": "ChEBI", "url": "" }, { "id": "87167", "database": "ChEBI", "url": "" }, { "id": "000031259909", "database": "ZINC", "url": "" }, { "id": "87167", "database": "ChEBI", "url": "" }, { "id": "000031259909", "database": "ZINC", "url": "" }, { "id": "000031259909", "database": "ZINC", "url": "" }, { "id": "87167", "database": "ChEBI", "url": "" }, { "id": "87167", "database": "ChEBI", "url": "" }, { "id": "000031259909", "database": "ZINC", "url": "" }, { "id": "87167", "database": "ChEBI", "url": "" }, { "id": "000031259909", "database": "ZINC", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "O60725", "gene_name": "ICMT", "activity": [ { "ec_number": "2.1.1.100", "activity": "[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine.", "evidence": [ { "id": "O60725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60725" } ] }, { "ec_number": "2.1.1.100", "activity": "", "evidence": [ { "id": "O60725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60725" } ] } ] }, { "uniprot_ac": "P01111", "gene_name": "NRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01111" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01111" } ] } ] }, { "uniprot_ac": "P01112", "gene_name": "HRAS", "activity": [ { "ec_number": "3.6.5.2", "activity": "GTP + H2O = GDP + H(+) + phosphate.", "evidence": [ { "id": "P01112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P01112" } ] }, { "ec_number": "3.6.5.2", "activity": "", "evidence": [ { "id": "P01112", "database": "UniProtKB", "url": 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