{ "uniprot_canonical_ac": "O60658-1", "uniprot_ac": "O60658", "uniprot_id": "PDE8A_HUMAN", "mass": { "chemical_mass": 93304.0, "monoisotopic_mass": 93304.0 }, "refseq": { "ac": "NP_001230066", "name": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 3", "summary": "The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" }, "gene_names": [ { "name": "PDE8A", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60658", "id": "O60658" }, { "name": "HsT19550", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066", "id": "NP_001230066" }, { "name": "PDE8A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066", "id": "NP_001230066" } ], "protein_names": [ { "name": "High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60658" }, { "name": "3.1.4.53", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60658" }, { "name": "cAMP-specific cyclic nucleotide phosphodiesterase 8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066", "id": "NP_001230066" }, { "name": "high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform 3", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066", "id": "NP_001230066" } ], "function": [ { "annotation": "CAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001230066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" }, { "database": "PubMed", "id": "36277728", "url": "https://glygen.org/publication/PubMed/36277728" } ] }, { "annotation": "Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A.", "evidence": [ { "database": "RefSeq", "id": "NP_001230066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" }, { "database": "PubMed", "id": "12681444", "url": "https://glygen.org/publication/PubMed/12681444" } ] }, { "annotation": "Editing of PDE8A mRNA displayed clear regional difference when comparing dorsolateral prefrontal cortex (BA9) and anterior cingulate cortex (BA24). There were significant intra-regional differences between non-psychiatric control individuals and depressed suicide decedents. Erratum:[Transl Psychiatry. 2019 Mar 14;9(1):112. PMID: 30872571] Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001230066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" }, { "database": "PubMed", "id": "30770787", "url": "https://glygen.org/publication/PubMed/30770787" } ] }, { "annotation": "Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658#function" }, { "database": "PubMed", "id": "23509299", "url": "https://glygen.org/publication/PubMed/23509299" }, { "database": "PubMed", "id": "18983167", "url": "https://glygen.org/publication/PubMed/18983167" } ] }, { "annotation": "PDE8 is expressed in lipid rafts of human airway smooth muscle cells(HASM), where it specifically regulates beta2-adrenergic receptor/ AC6 signaling to modulate HASM responsiveness and airway remodeling in asthma.", "evidence": [ { "database": "RefSeq", "id": "NP_001230066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" }, { "database": "PubMed", "id": "29262264", "url": "https://glygen.org/publication/PubMed/29262264" } ] }, { "annotation": "Phosphodiesterase 8A Regulates CFTR Activity in Airway Epithelial Cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001230066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" }, { "database": "PubMed", "id": "34936285", "url": "https://glygen.org/publication/PubMed/34936285" } ] }, { "annotation": "Phosphodiesterase 8A to discriminate in blood samples depressed patients and suicide attempters from healthy controls based on A-to-I RNA editing modifications. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001230066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" }, { "database": "PubMed", "id": "33931591", "url": "https://glygen.org/publication/PubMed/33931591" } ] }, { "annotation": "The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001230066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230066" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 454, "end_pos": 455, "sequence_org": "RR", "sequence_mut": "AA", "comment": "Reduces interaction with RAF1; when associated with A-460 and A-461.", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "PubMed", "id": "23509299", "url": "https://glygen.org/publication/PubMed/23509299" } ] }, { "start_pos": 460, "end_pos": 461, "sequence_org": "EY", "sequence_mut": "AA", "comment": "Reduces interaction with RAF1; when associated with A-454 and A-455.", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "PubMed", "id": "23509299", "url": "https://glygen.org/publication/PubMed/23509299" } ] }, { "start_pos": 748, "end_pos": 748, "sequence_org": "Y", "sequence_mut": "F", "comment": "Increases sensitivity to several nonselective or family selective PDE inhibitors.", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "PubMed", "id": "18983167", "url": "https://glygen.org/publication/PubMed/18983167" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "92.07", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "81.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "89.62", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "89.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "89.49", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "94.87", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "87.16", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "92.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "90.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "81.01", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "94.94", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "91.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.48", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000073417", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000073417" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60658", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60658" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O60658", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60658" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "No", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O60658", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60658" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O60658", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60658" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O60658", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60658" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60658", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60658" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60658" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of abdominal esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant tumor of the middle Third of the esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal cancer", "description": "A primary or metastatic malignant neoplasm involving the esophagus." }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "cancer of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "esophageal 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"Protein" ] }, { "id": "H0YNP3-1", "url": "https://www.uniprot.org/uniprot/H0YNP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60658-1", "url": "https://www.uniprot.org/uniprot/O60658-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60658-2", "url": "https://www.uniprot.org/uniprot/O60658-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60658-3", "url": "https://www.uniprot.org/uniprot/O60658-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60658-4", "url": "https://www.uniprot.org/uniprot/O60658-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60658-5", "url": "https://www.uniprot.org/uniprot/O60658-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60658-6", "url": "https://www.uniprot.org/uniprot/O60658-6", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE", "length": 829, "header": "sp|O60658-1|PDE8A_HUMAN Isoform 1 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=2 CANONICAL=O60658-1" }, "isoforms": [ { "isoform_ac": "E9PIJ0-1", "url": "", "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQPCCSSSWFGAVHIPSSAPVEVGVGLLPSWSLRRT", "length": 272, "header": "tr|E9PIJ0-1|E9PIJ0_HUMAN Computationally mapped isoform of Phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=1 CANONICAL=O60658-1" }, "locus": { "chromosome": "15", "start_pos": 85090819, "end_pos": 84982163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000485596.5", "url": "https://www.ensembl.org/id/ENST00000485596.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000431976.1", "url": "https://www.ensembl.org/id/ENSP00000431976.1" } ] } }, { "isoform_ac": "H0YKR1-1", "url": "", "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRSGKEFTMPKRKTEIIYNKM", "length": 231, "header": "tr|H0YKR1-1|H0YKR1_HUMAN Computationally mapped isoform of Phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=1 CANONICAL=O60658-1" }, "locus": { "chromosome": "15", "start_pos": 85098005, "end_pos": 84982163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000559742.5", "url": "https://www.ensembl.org/id/ENST00000559742.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000452907.1", "url": "https://www.ensembl.org/id/ENSP00000452907.1" } ] } }, { "isoform_ac": "H0YNP3-1", "url": "", "sequence": { "sequence": "AAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRGM", "length": 126, "header": "tr|H0YNP3-1|H0YNP3_HUMAN Computationally mapped isoform of Phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=1 CANONICAL=O60658-1" }, "locus": { "chromosome": "15", "start_pos": 85083562, "end_pos": 84982226, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000559086.5", "url": "https://www.ensembl.org/id/ENST00000559086.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000454094.1", "url": "https://www.ensembl.org/id/ENSP00000454094.1" } ] } }, { "isoform_ac": "O60658-1", "url": "", "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE", "length": 829, "header": "sp|O60658-1|PDE8A_HUMAN Isoform 1 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=2 CANONICAL=O60658-1" }, "locus": { "chromosome": "15", "start_pos": 85137900, "end_pos": 84982163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000310298.8", "url": "https://www.ensembl.org/id/ENST00000310298.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000311453.4", "url": "https://www.ensembl.org/id/ENSP00000311453.4" } ] } }, { "isoform_ac": "O60658-2", "url": "", "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE", "length": 783, "header": "sp|O60658-2|PDE8A_HUMAN Isoform 2 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=2 CANONICAL=O60658-1" }, "locus": { "chromosome": "15", "start_pos": 85137900, "end_pos": 84982163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000339708.9", "url": "https://www.ensembl.org/id/ENST00000339708.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000340679.5", "url": "https://www.ensembl.org/id/ENSP00000340679.5" } ] } }, { "isoform_ac": "O60658-3", "url": "", "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRSGKEFTMQKRKTEIIYNKM", "length": 231, "header": "sp|O60658-3|PDE8A_HUMAN Isoform 3 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=2 CANONICAL=O60658-1" }, "locus": {} }, { "isoform_ac": "O60658-4", "url": "", "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLSMQILHLKQQWAISQVN", "length": 228, "header": "sp|O60658-4|PDE8A_HUMAN Isoform 4 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=2 CANONICAL=O60658-1" }, "locus": { "chromosome": "15", "start_pos": 85091092, "end_pos": 84982163, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000478717.5", "url": "https://www.ensembl.org/id/ENST00000478717.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000432309.1", "url": "https://www.ensembl.org/id/ENSP00000432309.1" } ] } }, { "isoform_ac": "O60658-5", "url": "", "sequence": { "sequence": "MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQPCCSSSWFGAAHIPSSAPVEVGVGLLPSWSLRRT", "length": 272, "header": "sp|O60658-5|PDE8A_HUMAN Isoform 5 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=2 CANONICAL=O60658-1" }, "locus": {} }, { "isoform_ac": "O60658-6", "url": "", "sequence": { "sequence": "MRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE", "length": 757, "header": "sp|O60658-6|PDE8A_HUMAN Isoform 6 of High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A OS=Homo sapiens OX=9606 GN=PDE8A PE=1 SV=2 CANONICAL=O60658-1" }, "locus": { "chromosome": "15", "start_pos": 85137900, "end_pos": 85064400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000557957.5", "url": "https://www.ensembl.org/id/ENST00000557957.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000453808.1", "url": "https://www.ensembl.org/id/ENSP00000453808.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 20, "end_pos": 20, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60658", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60658" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser20" }, { "start_pos": 359, "end_pos": 359, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by PKA", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "iPTMnet", "id": "O60658", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60658" }, { "database": "PubMed", "id": "22673573", "url": "https://glygen.org/publication/PubMed/22673573" } ], "site_lbl": "Ser359" }, { "start_pos": 386, "end_pos": 386, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "iPTMnet", "id": "O60658", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60658" }, { "database": "PubMed", "id": "18212344", "url": "https://glygen.org/publication/PubMed/18212344" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O60658", "url": "http://phospho.elm.eu.org/byAccession/O60658.html" } ], "site_lbl": "Ser386" }, { "start_pos": 407, "end_pos": 407, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60658", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60658" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser407" }, { "start_pos": 457, "end_pos": 457, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "18691976", "url": "https://glygen.org/publication/PubMed/18691976" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60658", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60658" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "phospho.ELM", "id": "O60658", "url": "http://phospho.elm.eu.org/byAccession/O60658.html" } ], "site_lbl": "Ser457" }, { "start_pos": 461, "end_pos": 461, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "site_lbl": "Tyr461" }, { "start_pos": 464, "end_pos": 464, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60658", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60658" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Ser464" }, { "start_pos": 465, "end_pos": 465, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60658", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60658" }, { "database": "PubMed", "id": "17081983", "url": "https://glygen.org/publication/PubMed/17081983" } ], "site_lbl": "Thr465" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Src tyrosine kinase is a novel direct effector of G proteins.", "journal": "Cell", "date": "2000", "authors": "Ma YC, Huang J, Ali S, Lowry W, Huang XY", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "11007482", "url": "https://glygen.org/publication/PubMed/11007482" } ] }, { "title": "T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2001", "authors": "Glavas NA, Ostenson C, Schaefer JB, Vasta V, Beavo JA", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "reference": [ { "type": "PubMed", "id": "11371644", "url": "https://glygen.org/publication/PubMed/11371644" } ] }, { "title": "Human phosphodiesterase 8A splice variants: cloning, gene organization, and tissue distribution.", "journal": "Gene", "date": "2001", "authors": "Wang P, Wu P, Egan R W, Billah M M", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "reference": [ { "type": "PubMed", "id": "11738832", "url": "https://glygen.org/publication/PubMed/11738832" } ] }, { "title": "Selective inhibition of heterotrimeric Gs signaling. 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Commun.", "date": "1998", "authors": "Fisher D A, Smith J F, Pillar J S, St Denis S H, Cheng J B", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "reference": [ { "type": "PubMed", "id": "9618252", "url": "https://glygen.org/publication/PubMed/9618252" } ] }, { "title": "Stimulation of type 1 and type 8 Ca2+/calmodulin-sensitive adenylyl cyclases by the Gs-coupled 5-hydroxytryptamine subtype 5-HT7A receptor.", "journal": "The Journal of biological chemistry", "date": "1998", "authors": "Baker LP, Nielsen MD, Impey S, Metcalf MA, Poser SW, Chan G, Obrietan K, Hamblin MW, Storm DR", "evidence": [ { "database": "Reactome", "id": "R-HSA-418555", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418555" } ], "reference": [ { "type": "PubMed", "id": "9651336", "url": "https://glygen.org/publication/PubMed/9651336" } ] } ], "pathway": [ { "id": "hsa:5151", "name": "", "url": 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"go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "pmid": "" }, { "name": "protein kinase activator activity", "id": "GO:0030295", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030295", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "pmid": "" }, { "name": "kinase binding", "id": "GO:0019900", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019900", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "pmid": "" }, { "name": "3',5'-cyclic-GMP phosphodiesterase activity", "id": "GO:0047555", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047555", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "pmid": "" }, { "name": "3',5'-cyclic-AMP phosphodiesterase activity", "id": "GO:0004115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004115", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 347, "end_pos": 349, "annotation": "n_glycosylation_sequon" }, { "start_pos": 557, "end_pos": 559, "annotation": "n_glycosylation_sequon" }, { "start_pos": 620, "end_pos": 622, "annotation": "n_glycosylation_sequon" }, { "start_pos": 713, "end_pos": 715, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity.", "evidence": [ { "database": "UniProtKB", "id": "O60658", "url": "https://www.uniprot.org/uniprot/O60658" }, { "database": "PubMed", "id": "22673573", "url": "https://glygen.org/publication/PubMed/22673573" } ] } ], "interactions": [], "reactions": [ { "id": "25277", "name": "", "equation": "3',5'-cyclic AMP + H2O = AMP + H(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VID6-1", "O08593-1", "P14644-1", "Q63421-1", "P54748-1", "P14270-5", "P14646-3", "Q9QYJ6-1", "A0A8I6A416-1", "Q01066-1", "Q62865-1", "Q01062-1", "Q924C3-1", "Q63085-1", "Q07343-1", "Q08499-1", "O60658-1", "O95263-1", "Q08493-1", "Q13946-1", "Q9NP56-1", "Q9HCR9-1", "P27815-1", "Q14123-1", "Q9Y233-3", "O00408-1", "Q13370-1", "P22413-1", "P54750-1", "Q01064-1", "Q14432-1", "Q01063-1", "Q01065-1", "E9Q4S1-1", "Q9QXQ1-1", "O88502-1", "O89084-1", "P0C1Q2-1", "P70453-1", "Q3UEI1-1", "Q64338-3", "Q8CA95-1", "B1AWC9-1", "Q61481-4", "Q61409-1", "Q9Z0X4-1", "P06802-1", "Q922S4-1", "P06776-1", "P12019-1", "Q23917-1", "Q54HY0-1", "Q86H13-1", "Q8MM62-1", "Q9W4T4-1", "Q6NNF2-1", "B7YZV4-1", "Q9VJ79-1" ], "evidence": [ { "id": "25277", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/25277" } ] }, { "id": "R-HSA-418553", "name": "cAMP degradation by Phosphodiesterases", "equation": "", "summary": "Cyclic nucleotide phosphodiesterases (PDEs) are a large family of enzymes that regulate signal transduction by the second messenger molecules cAMP and cGMP. Some PDEs are cAMP selective (PDE4, 7 and 8), some cGMP selective (PDE5, 6 and 9) while others can hydrolyse cAMP and cGMP (PDE1, 2, 3, 10 and 11). PDEs are important as drug targets: Sildenafil (Viagra) is an inhibitor of PDE5; Cilostazol (Pletal) inhibits PDE3, increasing the flexibility of erythrocytes.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P27815-1", "Q13946-1", "O00408-1", "Q08499-1", "Q9NP56-1", "O60658-1", "O95263-1", "P54750-1", "Q01064-1", "Q08493-1", "Q9Y233-3", "Q9HCR9-1" ], "evidence": [ { "id": "R-HSA-418553", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-418553" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A8I6A416", "gene_name": "Pde1a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "A0A8I6A416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A416" } ] } ] }, { "uniprot_ac": "B1AWC9", "gene_name": "Pde4b", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "B1AWC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWC9" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "B1AWC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWC9" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "B1AWC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1AWC9" } ] } ] }, { "uniprot_ac": "B7YZV4", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "B7YZV4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B7YZV4" } ] } ] }, { "uniprot_ac": "E9Q4S1", "gene_name": "Pde8b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "E9Q4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q4S1" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "E9Q4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q4S1" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "E9Q4S1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9Q4S1" } ] } ] }, { "uniprot_ac": "O00408", "gene_name": "PDE2A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O00408", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00408" } ] } ] }, { "uniprot_ac": "O08593", "gene_name": "Pde7a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "O08593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08593" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O08593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08593" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O08593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08593" } ] } ] }, { "uniprot_ac": "O60658", "gene_name": "PDE8A", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O60658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60658" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O60658", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60658" } ] } ] }, { "uniprot_ac": "O88502", "gene_name": "Pde8a", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O88502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88502" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O88502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88502" } ] } ] }, { "uniprot_ac": "O89084", "gene_name": "Pde4a", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O89084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89084" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O89084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O89084" } ] } ] }, { "uniprot_ac": "O95263", "gene_name": "PDE8B", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "O95263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95263" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "O95263", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95263" } ] } ] }, { "uniprot_ac": "P06776", "gene_name": "PDE2", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P06776", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06776" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P06776", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06776" } ] } ] }, { "uniprot_ac": "P06802", "gene_name": "Enpp1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "P06802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06802" } ] }, { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "P06802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06802" } ] } ] }, { "uniprot_ac": "P0C1Q2", "gene_name": "Pde11a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P0C1Q2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1Q2" } ] } ] }, { "uniprot_ac": "P12019", "gene_name": "pdsA", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P12019", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12019" } ] } ] }, { "uniprot_ac": "P14270", "gene_name": "Pde4d", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P14270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14270" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P14270", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14270" } ] } ] }, { "uniprot_ac": "P14644", "gene_name": "Pde4c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P14644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14644" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P14644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14644" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P14644", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14644" } ] } ] }, { "uniprot_ac": "P14646", "gene_name": "Pde4b", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14646" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P14646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14646" } ] } ] }, { "uniprot_ac": "P22413", "gene_name": "ENPP1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "P22413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22413" } ] }, { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "P22413", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22413" } ] } ] }, { "uniprot_ac": "P27815", "gene_name": "PDE4A", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P27815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27815" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P27815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P27815" } ] } ] }, { "uniprot_ac": "P54748", "gene_name": "Pde4a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "P54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54748" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54748" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P54748", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54748" } ] } ] }, { "uniprot_ac": "P54750", "gene_name": "PDE1A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "P54750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54750" } ] } ] }, { "uniprot_ac": "P70453", "gene_name": "Pde7a", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "P70453", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70453" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "P70453", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70453" } ] } ] }, { "uniprot_ac": "Q01062", "gene_name": "Pde2a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01062" } ] } ] }, { "uniprot_ac": "Q01063", "gene_name": "Pde4d", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01063" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q01063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01063" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q01063", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01063" } ] } ] }, { "uniprot_ac": "Q01064", "gene_name": "PDE1B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01064", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01064" } ] } ] }, { "uniprot_ac": "Q01065", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01065", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01065" } ] } ] }, { "uniprot_ac": "Q01066", "gene_name": "Pde1b", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q01066", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01066" } ] } ] }, { "uniprot_ac": "Q07343", "gene_name": "PDE4B", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q07343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07343" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q07343", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07343" } ] } ] }, { "uniprot_ac": "Q08493", "gene_name": "PDE4C", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q08493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08493" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q08493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08493" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q08493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08493" } ] } ] }, { "uniprot_ac": "Q08499", "gene_name": "PDE4D", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q08499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08499" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q08499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08499" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q08499", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08499" } ] } ] }, { "uniprot_ac": "Q13370", "gene_name": "PDE3B", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q13370", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13370" } ] } ] }, { "uniprot_ac": "Q13946", "gene_name": "PDE7A", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q13946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13946" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q13946", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13946" } ] } ] }, { "uniprot_ac": "Q14123", "gene_name": "PDE1C", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q14123", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14123" } ] } ] }, { "uniprot_ac": "Q14432", "gene_name": "PDE3A", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q14432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14432" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q14432", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14432" } ] } ] }, { "uniprot_ac": "Q23917", "gene_name": "regA", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q23917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23917" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q23917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23917" } ] } ] }, { "uniprot_ac": "Q3UEI1", "gene_name": "Pde4c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q3UEI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UEI1" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q3UEI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UEI1" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q3UEI1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UEI1" } ] } ] }, { "uniprot_ac": "Q54HY0", "gene_name": "pde7", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q54HY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54HY0" } ] } ] }, { "uniprot_ac": "Q61409", "gene_name": "Pde3b", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q61409", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61409" } ] } ] }, { "uniprot_ac": "Q61481", "gene_name": "Pde1a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q61481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61481" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q61481", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q61481" } ] } ] }, { "uniprot_ac": "Q62865", "gene_name": "Pde3a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q62865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62865" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q62865", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62865" } ] } ] }, { "uniprot_ac": "Q63085", "gene_name": "Pde3b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q63085", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63085" } ] } ] }, { "uniprot_ac": "Q63421", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q63421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63421" } ] } ] }, { "uniprot_ac": "Q64338", "gene_name": "Pde1c", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q64338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64338" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q64338", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64338" } ] } ] }, { "uniprot_ac": "Q6NNF2", "gene_name": "Pde8", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q6NNF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NNF2" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q6NNF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6NNF2" } ] } ] }, { "uniprot_ac": "Q86H13", "gene_name": "Pde4", "activity": [ { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q86H13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86H13" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q86H13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86H13" } ] } ] }, { "uniprot_ac": "Q8CA95", "gene_name": "Pde10a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q8CA95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CA95" } ] } ] }, { "uniprot_ac": "Q8MM62", "gene_name": "pdeE", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8MM62", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8MM62" } ] } ] }, { "uniprot_ac": "Q8VID6", "gene_name": "Pde11a", "activity": [ { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q8VID6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VID6" } ] } ] }, { "uniprot_ac": "Q922S4", "gene_name": "Pde2a", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] }, { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q922S4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922S4" } ] } ] }, { "uniprot_ac": "Q924C3", "gene_name": "Enpp1", "activity": [ { "ec_number": "3.1.4.1", "activity": "Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.", "evidence": [ { "id": "Q924C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924C3" } ] }, { "ec_number": "3.6.1.9", "activity": "CTP + H2O = CMP + diphosphate + H(+).", "evidence": [ { "id": "Q924C3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924C3" } ] } ] }, { "uniprot_ac": "Q9HCR9", "gene_name": "PDE11A", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9HCR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCR9" } ] } ] }, { "uniprot_ac": "Q9NP56", "gene_name": "PDE7B", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9NP56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP56" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9NP56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP56" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9NP56", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NP56" } ] } ] }, { "uniprot_ac": "Q9QXQ1", "gene_name": "Pde7b", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9QXQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXQ1" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9QXQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXQ1" } ] }, { "ec_number": "3.1.4.53", "activity": "", "evidence": [ { "id": "Q9QXQ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QXQ1" } ] } ] }, { "uniprot_ac": "Q9QYJ6", "gene_name": "Pde10a", "activity": [ { "ec_number": "3.1.4.17", "activity": "a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+).", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] }, { "ec_number": "3.1.4.17", "activity": "", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] }, { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9QYJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9QYJ6" } ] } ] }, { "uniprot_ac": "Q9VJ79", "gene_name": "Pde11", "activity": [ { "ec_number": "3.1.4.-", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.35", "activity": "3',5'-cyclic GMP + H2O = GMP + H(+).", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.53", "activity": "3',5'-cyclic AMP + H2O = AMP + H(+).", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.35", "activity": "", "evidence": [ { "id": "Q9VJ79", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9VJ79" } ] }, { "ec_number": "3.1.4.53", "activity": 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