{ "uniprot_canonical_ac": "O60613-1", "uniprot_ac": "O60613", "uniprot_id": "SEP15_HUMAN", "mass": { "chemical_mass": 18092.0, "monoisotopic_mass": 18092.0 }, "refseq": { "ac": "NP_004252", "name": "selenoprotein F isoform 1 precursor", "summary": "The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" }, "gene_names": [ { "name": "SELENOF", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60613", "id": "O60613" }, { "name": "SELENOF", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252", "id": "NP_004252" }, { "name": "SEP15", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252", "id": "NP_004252" }, { "name": "SEP15", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60613", "id": "O60613" } ], "protein_names": [ { "name": "Selenoprotein F", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60613" }, { "name": "15 kDa selenoprotein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252", "id": "NP_004252" }, { "name": "15 kDa selenoprotein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60613" }, { "name": "selenoprotein F isoform 1 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252", "id": "NP_004252" } ], "function": [ { "annotation": "Distinct Roles of SELENOF in Different Human Cancers. Review article Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" }, { "database": "PubMed", "id": "36979420", "url": "https://glygen.org/publication/PubMed/36979420" } ] }, { "annotation": "Genetic and functional analysis of mammalian Sep15 selenoprotein.", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" }, { "database": "PubMed", "id": "11898406", "url": "https://glygen.org/publication/PubMed/11898406" } ] }, { "annotation": "Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" }, { "database": "PubMed", "id": "34769469", "url": "https://glygen.org/publication/PubMed/34769469" } ] }, { "annotation": "May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum (PubMed:24415556). May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (PubMed:24415556).", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613#function" }, { "database": "PubMed", "id": "24415556", "url": "https://glygen.org/publication/PubMed/24415556" }, { "database": "UniProtKB", "id": "Q923V8", "url": "https://www.uniprot.org/uniprot/Q923V8#function" } ] }, { "annotation": "One-Pot Chemical Protein Synthesis Utilizing Fmoc-Masked Selenazolidine to Address the Redox Functionality of Human Selenoprotein F.", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" }, { "database": "PubMed", "id": "35112407", "url": "https://glygen.org/publication/PubMed/35112407" } ] }, { "annotation": "Role of SELENBP1 and SELENOF in prostate cancer bioenergetics. Review article", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" }, { "database": "PubMed", "id": "36334799", "url": "https://glygen.org/publication/PubMed/36334799" } ] }, { "annotation": "Studies in mouse show that Sep15 may have redox function.", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" }, { "database": "PubMed", "id": "12600282", "url": "https://glygen.org/publication/PubMed/12600282" } ] }, { "annotation": "The protein encoded by this gene belongs to the SEP15/selenoprotein M family. The exact function of this protein is not known; however, it has been found to associate with UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic reticulum(ER)-resident protein, which is involved in the quality control of protein folding. The association with UGTR retains this protein in the ER, where it may play a role in protein folding. It has also been suggested to have a role in cancer etiology. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 96, "end_pos": 96, "sequence_org": "U", "sequence_mut": "C", "comment": "Does not affect protein folding and binding to UGGT1 or UGGT2.", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613" }, { "database": "PubMed", "id": "24415556", "url": "https://glygen.org/publication/PubMed/24415556" } ] } ], "expression_tissue": [], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60613", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60613" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O60613", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60613" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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{ "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O60613", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60613" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": 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kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "No", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60613", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60613" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60613" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "malignant tumour of the oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "oesophagus cancer", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third esophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca lower third oesophagus", "description": "" }, { "id": "MONDO:0007576", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0007576", "name": "Ca middle third esophagus", "description": "" }, { "id": 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OX=9606 GN=SELENOF PE=1 SV=1 CANONICAL=O60613-1" }, "locus": {} }, { "isoform_ac": "A8MZD0-1", "url": "", "sequence": { "sequence": "MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKYSSIVSKQECHHSNCMQELFLKFVDENWEGSLKSKLLLGVINPNCSEDCKSSMSVVQTLY", "length": 144, "header": "tr|A8MZD0-1|A8MZD0_HUMAN Computationally mapped isoform of Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=2 CANONICAL=O60613-1" }, "locus": { "chromosome": "1", "start_pos": 86914111, "end_pos": 86863581, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000401030.4", "url": "https://www.ensembl.org/id/ENST00000401030.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000383810.4", "url": "https://www.ensembl.org/id/ENSP00000383810.4" } ] } }, { "isoform_ac": "O60613-1", "url": "", "sequence": { "sequence": "MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLERI", "length": 165, "header": "sp|O60613-1|SEP15_HUMAN Isoform 1 of Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4 CANONICAL=O60613-1" }, "locus": { "chromosome": "1", "start_pos": 86914111, "end_pos": 86863477, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000331835.10", "url": "https://www.ensembl.org/id/ENST00000331835.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000328729.6", "url": "https://www.ensembl.org/id/ENSP00000328729.6" } ] } }, { "isoform_ac": "O60613-2", "url": "", "sequence": { "sequence": "MVAMAAGPSGCLVPAFGLRLLLATVLQAVSAFGAEFSSEACRELGFSSNLLCSSCDLLGQFNLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQVCPWFRPCIKAFGRQWEHC", "length": 124, "header": "sp|O60613-2|SEP15_HUMAN Isoform 2 of Selenoprotein F OS=Homo sapiens OX=9606 GN=SELENOF PE=1 SV=4 CANONICAL=O60613-1" }, "locus": { "chromosome": "1", "start_pos": 86914111, "end_pos": 86863550, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000370554.5", "url": "https://www.ensembl.org/id/ENST00000370554.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000359585.2", "url": "https://www.ensembl.org/id/ENSP00000359585.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Kumaraswamy E, Malykh A, Korotkov KV, Kozyavkin S, Hu Y, Kwon SY, Moustafa ME, Carlson BA, Berry MJ, Lee BJ, Hatfield DL, Diamond AM, Gladyshev VN", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613" } ], "reference": [ { "type": "PubMed", "id": "10945981", "url": "https://glygen.org/publication/PubMed/10945981" } ] }, { "title": "Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells.", "journal": "J. Biol. Chem.", "date": "2001", "authors": "Korotkov KV, Kumaraswamy E, Zhou Y, Hatfield DL, Gladyshev VN", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613" } ], "reference": [ { "type": "PubMed", "id": "11278576", "url": "https://glygen.org/publication/PubMed/11278576" } ] }, { "title": "Genetic and functional analysis of mammalian Sep15 selenoprotein.", "journal": "Methods in enzymology", "date": "2002", "authors": "Kumaraswamy E, Korotkov KV, Diamond AM, Gladyshev VN, Hatfield DL", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" } ], "reference": [ { "type": "PubMed", "id": "11898406", "url": "https://glygen.org/publication/PubMed/11898406" } ] }, { "title": "[Redox reactions of Sep15 and its relationship with tumor development].", "journal": "Ai zheng = Aizheng = Chinese journal of cancer", "date": "2003", "authors": "Wu HJ, Lin C, Zha YY, Yang JG, Zhang MC, Zhang XY, Liang X, Fu M, Wu M", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" } ], "reference": [ { "type": "PubMed", "id": "12600282", "url": "https://glygen.org/publication/PubMed/12600282" } ] }, { "title": "Both isoforms of human UDP-glucose:glycoprotein glucosyltransferase are enzymatically active.", "journal": "Glycobiology", "date": "2014", "authors": "Takeda Y, Seko A, Hachisu M, Daikoku S, Izumi M, Koizumi A, Fujikawa K, Kajihara Y, Ito Y", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613" } ], "reference": [ { "type": "PubMed", "id": "24415556", "url": "https://glygen.org/publication/PubMed/24415556" } ] }, { "title": "Selenoprotein gene nomenclature.", "journal": "J. Biol. Chem.", "date": "2016", "authors": "Gladyshev Vadim N, Arn\u00e9r Elias S, Berry Marla J, Brigelius-Floh\u00e9 Regina, Bruford Elspeth A, Burk Raymond F, Carlson Bradley A, Castellano Sergi, Chavatte Laurent, Conrad Marcus, Copeland Paul R, Diamond Alan M, Driscoll Donna M, Ferreiro Ana, Floh\u00e9 Leopold, Green Fiona R, Guig\u00f3 Roderic, Handy Diane E, Hatfield Dolph L, Hesketh John, Hoffmann Peter R, Holmgren Arne, Hondal Robert J, Howard Michael T, Huang Kaixun, Kim Hwa-Young, Kim Ick Young, K\u00f6hrle Josef, Krol Alain, Kryukov Gregory V, Lee Byeong Jae, Lee Byung Cheon, Lei Xin Gen, Liu Qiong, Lescure Alain, Lobanov Alexei V, Loscalzo Joseph, Maiorino Matilde, Mariotti Marco, Sandeep Prabhu K, Rayman Margaret P, Rozovsky Sharon, Salinas Gustavo, Schmidt Edward E, Schomburg Lutz, Schweizer Ulrich, Simonovi\u0107 Miljan, Sunde Roger A, Tsuji Petra A, Tweedie Susan, Ursini Fulvio, Whanger Philip D, Zhang Yan", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613" } ], "reference": [ { "type": "PubMed", "id": "27645994", "url": "https://glygen.org/publication/PubMed/27645994" } ] }, { "title": "The interaction of selenoprotein F (SELENOF) with retinol dehydrogenase 11 (RDH11) implied a role of SELENOF in vitamin A metabolism.", "journal": "Nutr. Metab.", "date": "2018", "authors": "Tian J, Liu J, Li J, Zheng J, Chen L, Wang Y, Liu Q, Ni J", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613" } ], "reference": [ { "type": "PubMed", "id": "29410696", "url": "https://glygen.org/publication/PubMed/29410696" } ] }, { "title": "Loss of SELENOF Induces the Transformed Phenotype in Human Immortalized Prostate Epithelial Cells.", "journal": "International journal of molecular sciences", "date": "2021", "authors": "Hong LK, Kadkol S, Sverdlov M, Kastrati I, Elhodaky M, Deaton R, Sfanos KS, Wang H, Liu L, Diamond AM", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" } ], "reference": [ { "type": "PubMed", "id": "34769469", "url": "https://glygen.org/publication/PubMed/34769469" } ] }, { "title": "One-Pot Chemical Protein Synthesis Utilizing Fmoc-Masked Selenazolidine to Address the Redox Functionality of Human Selenoprotein F.", "journal": "Chemistry (Weinheim an der Bergstrasse, Germany)", "date": "2022", "authors": "Zhao Z, Mousa R, Metanis N", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" } ], "reference": [ { "type": "PubMed", "id": "35112407", "url": "https://glygen.org/publication/PubMed/35112407" } ] }, { "title": "Role of SELENBP1 and SELENOF in prostate cancer bioenergetics.", "journal": "Archives of biochemistry and biophysics", "date": "2022-12-15", "authors": "Bera Soumen, Diamond Alan M", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" } ], "reference": [ { "type": "PubMed", "id": "36334799", "url": "https://glygen.org/publication/PubMed/36334799" } ] }, { "title": "Distinct Roles of SELENOF in Different Human Cancers.", "journal": "Biomolecules", "date": "2023-03-06", "authors": "Flowers Brenna, Bochnacka Oliwia, Poles Allison, Diamond Alan M, Kastrati Irida", "evidence": [ { "database": "RefSeq", "id": "NP_004252", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004252" } ], "reference": [ { "type": "PubMed", "id": "36979420", "url": "https://glygen.org/publication/PubMed/36979420" } ] }, { "title": "A new human selenium-containing protein. 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Chem.", "date": "1998", "authors": "Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL", "evidence": [ { "database": "UniProtKB", "id": "O60613", "url": "https://www.uniprot.org/uniprot/O60613" } ], "reference": [ { "type": "PubMed", "id": "9535873", "url": "https://glygen.org/publication/PubMed/9535873" } ] } ], "pathway": [ { "id": "hsa:9403", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9403", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A1Z623-1", "protein_name": "Selenoprotein F", "gene_name": "SELENOF", "tax_id": 9823, "organism": "Sus scrofa", "sequence": { "sequence": "MAAEPGGWLGPALGLRLLLATALQMVSAFGAEFSSESCRELGFSSNLLCGSCDLLGQFDLLQLDPDCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQAFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLQRV", "length": 162 }, "evidence": [ { "id": "O60613", "url": "https://omabrowser.org/oma/group/O60613/", "database": "OMA" } ], "common_name": "Pig" }, { "uniprot_canonical_ac": "Q923V8-1", 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