{ "uniprot_canonical_ac": "O60551-1", "uniprot_ac": "O60551", "uniprot_id": "NMT2_HUMAN", "mass": { "chemical_mass": 56980.0, "monoisotopic_mass": 56980.0 }, "refseq": { "ac": "NP_001295224", "name": "glycylpeptide N-tetradecanoyltransferase 2 isoform 2", "summary": "This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224" }, "gene_names": [ { "name": "NMT2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60551", "id": "O60551" }, { "name": "NMT2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224", "id": "NP_001295224" } ], "protein_names": [ { "name": "Glycylpeptide N-tetradecanoyltransferase 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60551" }, { "name": "2.3.1.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60551" }, { "name": "2.3.1.97", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60551" }, { "name": "Myristoyl-CoA:protein N-myristoyltransferase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60551" }, { "name": "NMT 2; type II N-myristoyltransferase; peptide N-myristoyltransferase 2; myristoyl-CoA:protein N-myristoyltransferase 2; protein-lysine myristoyltransferase NMT2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224", "id": "NP_001295224" }, { "name": "NMT 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60551" }, { "name": "Peptide N-myristoyltransferase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60551" }, { "name": "Protein-lysine myristoyltransferase NMT2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60551" }, { "name": "Type II N-myristoyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60551" }, { "name": "glycylpeptide N-tetradecanoyltransferase 2 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224", "id": "NP_001295224" } ], "function": [ { "annotation": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:25255805, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551#function" }, { "database": "PubMed", "id": "9506952", "url": "https://glygen.org/publication/PubMed/9506952" }, { "database": "PubMed", "id": "25255805", "url": "https://glygen.org/publication/PubMed/25255805" }, { "database": "PubMed", "id": "32103017", "url": "https://glygen.org/publication/PubMed/32103017" } ] }, { "annotation": "Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.", "evidence": [ { "database": "UniProtKB", "id": "Q5VUC6", "url": "https://www.uniprot.org/uniprot/Q5VUC6#function" }, { "database": "UniProtKB", "id": "RU000586", "url": "https://www.uniprot.org/uniprot/RU000586#function" } ] }, { "annotation": "Ligand binding properties of the NMT/ACBD6 complex can explain how the NMT reaction can proceed in the presence of the very abundant competitive substrate, C(16)-CoA.", "evidence": [ { "database": "RefSeq", "id": "NP_001295224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224" }, { "database": "PubMed", "id": "26621918", "url": "https://glygen.org/publication/PubMed/26621918" } ] }, { "annotation": "N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas.", "evidence": [ { "database": "RefSeq", "id": "NP_001295224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224" }, { "database": "PubMed", "id": "35930829", "url": "https://glygen.org/publication/PubMed/35930829" } ] }, { "annotation": "Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence.", "evidence": [ { "database": "RefSeq", "id": "NP_001295224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224" }, { "database": "PubMed", "id": "18089753", "url": "https://glygen.org/publication/PubMed/18089753" } ] }, { "annotation": "This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001295224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295224" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "75.21", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "70.41", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "69.18", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "88.04", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "86.99", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "82.87", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "80.02", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "85.27", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "82.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "87.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000152465", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000152465" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60551", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60551" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, 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"http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O60551", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60551" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O60551", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60551" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O60551", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60551" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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N-tetradecanoyltransferase 2 OS=Homo sapiens OX=9606 GN=NMT2 PE=1 SV=1 CANONICAL=O60551-1" }, "isoforms": [ { "isoform_ac": "O60551-1", "url": "", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGYLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQPSKNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ", "length": 498, "header": "sp|O60551-1|NMT2_HUMAN Isoform 1 of Glycylpeptide N-tetradecanoyltransferase 2 OS=Homo sapiens OX=9606 GN=NMT2 PE=1 SV=1 CANONICAL=O60551-1" }, "locus": { "chromosome": "10", "start_pos": 15168612, "end_pos": 15109198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378165.9", "url": "https://www.ensembl.org/id/ENST00000378165.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000367407.3", "url": "https://www.ensembl.org/id/ENSP00000367407.3" } ] } }, { "isoform_ac": "Q5VUC6-1", "url": "", "sequence": { "sequence": "MRRRRSTPKEVLEGIWEPKRKRRNRREKRRNQIPEAPSQTRHLIPRRLKFSSLRNTTPSGSRFQREQPWNPSVPMQKLQDIQRAMELLSACQGPARNIDEAAKHRYQFWDTQPVPKLDEVITSHGAIEPDKDNVRQEPYSLPQGFMWDTLDLSDAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKKMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPIATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKSVRELINTYLKQFHLAPVMDEEEVAHWFLPREHIIDTFVVESPNGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMSDALILAKSKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ", "length": 485, "header": "tr|Q5VUC6-1|Q5VUC6_HUMAN Computationally mapped isoform of Glycylpeptide N-tetradecanoyltransferase OS=Homo sapiens OX=9606 GN=NMT2 PE=1 SV=1 CANONICAL=O60551-1" }, "locus": { "chromosome": "10", "start_pos": 15168530, "end_pos": 15109198, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378150.1", "url": "https://www.ensembl.org/id/ENST00000378150.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000367392.1", "url": "https://www.ensembl.org/id/ENSP00000367392.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 337, "end_pos": 337, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60551", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60551" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr337" }, { "start_pos": 338, "end_pos": 338, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60551", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60551" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Ser338" }, { "start_pos": 38, "end_pos": 38, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60551", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60551" }, { "database": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ], "site_lbl": "Ser38" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "10037746", "url": "https://glygen.org/publication/PubMed/10037746" } ] }, { "title": "The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Makino ER, Handy JW, Li T, Arshavsky VY", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "10051575", "url": "https://glygen.org/publication/PubMed/10051575" } ] }, { "title": "Structure, alternative splicing, and expression of the human RGS9 gene.", "journal": "Gene", "date": "1999", "authors": "Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "10564809", "url": "https://glygen.org/publication/PubMed/10564809" } ] }, { "title": "Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1.", "journal": "Nature", "date": "2000", "authors": "Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "10676965", "url": "https://glygen.org/publication/PubMed/10676965" } ] }, { "title": "Ubiquitination of HIV-1 and MuLV Gag.", "journal": "Virology", "date": "2000", "authors": "Ott DE, Coren LV, Chertova EN, Gagliardi TD, Schubert U", "evidence": [ { "database": "Reactome", "id": "R-HSA-174490", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490" } ], "reference": [ { "type": "PubMed", "id": "11112487", "url": "https://glygen.org/publication/PubMed/11112487" } ] }, { "title": "Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "11292825", "url": "https://glygen.org/publication/PubMed/11292825" } ] }, { "title": "The biology and enzymology of protein N-myristoylation.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Farazi TA, Waksman G, Gordon JI", "evidence": [ { "database": "Reactome", "id": "R-HSA-174490", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490" } ], "reference": [ { "type": "PubMed", "id": "11527981", "url": "https://glygen.org/publication/PubMed/11527981" } ] }, { "title": "Phosphorylation of the regulator of G protein signaling RGS9-1 by protein kinase A is a potential mechanism of light- and Ca2+-mediated regulation of G protein function in photoreceptors.", "journal": "Biochemistry", "date": "2001", "authors": "Balasubramanian N, Levay K, Keren-Raifman T, Faurobert E, Slepak VZ", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "11601986", "url": "https://glygen.org/publication/PubMed/11601986" } ] }, { "title": "The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2001", "authors": "Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "11687658", "url": "https://glygen.org/publication/PubMed/11687658" } ] }, { "title": "Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2).", "journal": "Molecular and cellular biology", "date": "2001", "authors": "Ramulu P, Kennedy M, Xiong WH, Williams J, Cowan M, Blesh D, Yau KW, Hurley JB, Nathans J", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "11713293", "url": "https://glygen.org/publication/PubMed/11713293" } ] }, { "title": "Characterization of human GRK7 as a potential cone 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Zartman CB", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "12036349", "url": "https://glygen.org/publication/PubMed/12036349" } ] }, { "title": "R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Hu G, Wensel TG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "12119397", "url": "https://glygen.org/publication/PubMed/12119397" } ] }, { "title": "Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Sokal I, Hu G, Liang Y, Mao M, Wensel 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RB, Robinson RG, Tsou NN, Walsh ES, Graham SL, Beese LS, Taylor JS", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "12825937", "url": "https://glygen.org/publication/PubMed/12825937" } ] }, { "title": "Molecular cloning of a retina-specific membrane guanylyl cyclase.", "journal": "Neuron", "date": "1992", "authors": "Shyjan AW, de Sauvage FJ, Gillett NA, Goeddel DV, Lowe DG", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "1356371", "url": "https://glygen.org/publication/PubMed/1356371" } ] }, { "title": "Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "1992", "authors": "Dhallan RS, Macke JP, Eddy RL, Shows TB, Reed RR, Yau KW, Nathans J", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "1379636", "url": "https://glygen.org/publication/PubMed/1379636" } ] }, { "title": "Isolation of human retinal genes: recoverin cDNA and gene.", "journal": "Biochemical and biophysical research communications", "date": "1992", "authors": "Murakami A, Yajima T, Inana G", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "1387789", "url": "https://glygen.org/publication/PubMed/1387789" } ] }, { "title": "Lipid modification at the N terminus of photoreceptor G-protein alpha-subunit.", "journal": "Nature", "date": "1992", "authors": "Kokame K, Fukada Y, Yoshizawa T, Takao T, Shimonishi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "1436039", "url": "https://glygen.org/publication/PubMed/1436039" } ] }, { "title": "Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.", "journal": "Nature", "date": "2004", "authors": "Nishiguchi KM, Sandberg MA, Kooijman AC, Martemyanov KA, Pott JW, Hagstrom SA, Arshavsky VY, Berson EL, Dryja TP", "evidence": [ { "database": "Reactome", "id": "R-HSA-2514859", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2514859" } ], "reference": [ { "type": "PubMed", "id": "14702087", "url": "https://glygen.org/publication/PubMed/14702087" } ] }, { "title": "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Stuchell MD, Garrus JE, Muller B, Stray KM, Ghaffarian S, McKinnon R, Krausslich HG, Morham SG, Sundquist WI", "evidence": [ { "database": "Reactome", "id": "R-HSA-174490", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490" } ], "reference": [ { "type": "PubMed", "id": "15218037", "url": "https://glygen.org/publication/PubMed/15218037" } ] }, { "title": "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.", "journal": "The Journal of biological chemistry", "date": "2005", "authors": "Eastman SW, Martin-Serrano J, Chung W, Zang T, Bieniasz PD", "evidence": [ { "database": "Reactome", "id": "R-HSA-174490", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490" } ], "reference": [ { "type": "PubMed", "id": "15509564", "url": "https://glygen.org/publication/PubMed/15509564" } ] }, { "title": "Human N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins.", "journal": "Journal of virology", "date": "2005", "authors": 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protein of Moloney murine leukemia virus.", "journal": "Journal of virology", "date": "1998", "authors": "Ott DE, Coren LV, Copeland TD, Kane BP, Johnson DG, Sowder RC 2nd, Yoshinaka Y, Oroszlan S, Arthur LO, Henderson LE", "evidence": [ { "database": "Reactome", "id": "R-HSA-174490", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490" } ], "reference": [ { "type": "PubMed", "id": "9525617", "url": "https://glygen.org/publication/PubMed/9525617" } ] } ], "pathway": [ { "id": "hsa:9397", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9397", "resource": "KEGG Pathway" }, { "id": "R-HSA-174490", "name": "Membrane binding and targetting of GAG proteins", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-174490", "resource": "Reactome", "description": "Membrane binding and targetting of GAG proteins" }, { "id": "R-HSA-2514859", "name": "Inactivation, recovery and regulation of the phototransduction cascade", "url": 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"database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O70311-1", "protein_name": "Glycylpeptide N-tetradecanoyltransferase 2", "gene_name": "Nmt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAEDSESAASQQSLELDDQDTCGIDGDNEEETEHAKGSPGGDLGAKKKKKKQKRKKEKPNSGGTKSDSASDSQEIKIQQSSKHNAIWQQISAGAAMGGDTMEGEWIDLRMYHKNPTIPIQKLQDIQRAMELLSACQGPARNIDEATKRRYQFWDTQPVPKLNEVITSHGAIEPDKDNIRQEPYSLPQGFMWDTLDLSNAEVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLLQWHCGVRVSSNKKLVGFISAIPANIRIYDSVKRMVEINFLCVHKKLRSKRVAPVLIREITRRVNLEGIFQAVYTAGVVLPKPVATCRYWHRSLNPRKLVEVKFSHLSRNMTLQRTMKLYRLPDVTKTSGLRPMEPKDIKAVRELINIYLKQFHLAPVMDDAEVAHWFLPREHIIDTFVVENPSGKLTDFLSFYTLPSTVMHHPAHKSLKAAYSFYNIHTETPLLDLMNDALIIAKLKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWRCPGTDSEKVGLVLQ", "length": 529 }, "evidence": [ { "id": "45920917", "url": "http://www.informatics.jax.org/homology/45920917", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 3, "go_terms": [ { "name": "N-terminal peptidyl-glycine N-myristoylation", "id": "GO:0018008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018008", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" }, { "name": "intracellular transport of virus", "id": "GO:0075733", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0075733", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" }, { "name": "regulation of rhodopsin mediated signaling pathway", "id": "GO:0022400", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022400", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" }, { "name": "host cell", "id": "GO:0043657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043657", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "glycylpeptide N-tetradecanoyltransferase activity", "id": "GO:0004379", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004379", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" }, { "name": "peptidyl-lysine N6-myristoyltransferase activity", "id": "GO:0018030", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018030", "evidence": [ { "database": "UniProtKB", "id": "O60551", "url": "https://www.uniprot.org/uniprot/O60551" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 319, "end_pos": 321, "annotation": "n_glycosylation_sequon" }, { "start_pos": 460, "end_pos": 462, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "15521", "name": "", "equation": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K1Q0-1", "A0A8I5ZWZ4-1", "O60551-1", "P30419-1", "O70311-1", "O70310-1", "P14743-1", "Q553B6-1", "O61613-1" ], "evidence": [ { "id": "15521", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/15521" } ] }, { "id": "70671", "name": "", "equation": "N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8I5ZWZ4-1", "Q8K1Q0-1", "P30419-1", "O60551-1", "O70311-1", "O70310-1" ], "evidence": [ { "id": "70671", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/70671" } ] }, { "id": "R-HSA-184392", "name": "N-myristoylation of GAG polyprotein by NMT2", "equation": "", "summary": "The amino terminal glycine residue of HIV-1 Gag polyprotein is myristoylated (Henderson et al. 1992). Myristoylation of newly synthesized Gag occurs in the cytosol of the infected host cell, with myristoyl-CoA as the myristate donor and the host cell NMT2 enzyme as the catalyst. Human cells express two isoforms of N-myristoyl transferase (NMT) (Giang and Cravatt 1998). The argumant that the second isoform catalyzes this reaction is indirect, based on the the observations that a stable enzyme:substrate complex forms transiently during the reaction (Farazi et al. 2001), and that Gag polyprotein can be found complexed with NMT2 (but not NMT1) in HIV-1-infected human cells (Hill and Skowronski 2005).", "cellular_location": "cytosol", "input_participant_list": [ "R-HIV-184393" ], "output_participant_list": [ "R-HIV-184427" ], "enzyme_list": [ "O60551-1" ], "evidence": [ { "id": "R-HSA-184392", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-184392" } ] }, { "id": "R-HSA-2534087", "name": "NMT1/2 transfer MYS to GNAT1", "equation": "", "summary": "After removal of the N-terminal methionine (Met) residue, the enzymes glycylpeptide N-tetradecanoyltransferase 1 and 2 (NMT1 and 2) mediate the transfer of the myristoyl (MYS) group from myristoyl-CoA to the now N-terminal glycine (Gly) residue of transducin's alpha subunit (GNAT1) (Glover et al. 1997, Giang & Cravatt 1998). Myristoylation is thought to aid enzyme function and localization. Evidence from chicken experiments suggest non-myristoylated proteins do not bind to membranes (Kamps et al. 1986).", "cellular_location": "cytosol, photoreceptor disc membrane", "input_participant_list": [ "R-ALL-2534019" ], "output_participant_list": [ "R-HSA-2534062" ], "enzyme_list": [ "O60551-1", "P30419-1" ], "evidence": [ { "id": "R-HSA-2534087", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2534087" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2534019", "participant_name": "MYS-CoA [cytosol]", "crossref": [ { "id": "C02593", "database": "COMPOUND", "url": "" }, { "id": "000195445287", "database": "ZINC", "url": "" }, { "id": "HMDB0001521", "database": "HMDB Metabolite", "url": "" }, { "id": "8143232", "database": "PubChem Substance", "url": "" }, { "id": "15532", "database": "ChEBI", "url": "" }, { "id": "15532", "database": "ChEBI", "url": "" }, { "id": "C02593", "database": "COMPOUND", "url": "" }, { "id": "8143232", "database": "PubChem Substance", "url": "" }, { "id": "000195445287", "database": "ZINC", "url": "" }, { "id": "HMDB0001521", "database": "HMDB Metabolite", "url": "" }, { "id": "000195445287", "database": "ZINC", "url": "" }, { "id": "C02593", "database": "COMPOUND", "url": "" }, { "id": "15532", "database": "ChEBI", "url": "" }, { "id": "HMDB0001521", "database": "HMDB Metabolite", "url": "" }, { "id": "8143232", "database": "PubChem Substance", "url": "" }, { "id": "000195445287", "database": "ZINC", "url": "" }, { "id": "C02593", "database": "COMPOUND", "url": "" }, { "id": "15532", "database": "ChEBI", "url": "" }, { "id": "HMDB0001521", "database": "HMDB Metabolite", "url": "" }, { "id": "8143232", "database": "PubChem Substance", "url": "" }, { "id": "15532", "database": "ChEBI", "url": "" }, { "id": "C02593", "database": "COMPOUND", "url": "" }, { "id": "8143232", "database": "PubChem Substance", "url": "" }, { "id": "000195445287", "database": "ZINC", "url": "" }, { "id": "HMDB0001521", "database": "HMDB Metabolite", "url": "" }, { "id": "C02593", "database": "COMPOUND", "url": "" }, { "id": "000195445287", "database": "ZINC", "url": "" }, { "id": "15532", "database": "ChEBI", "url": "" }, { "id": "HMDB0001521", "database": "HMDB Metabolite", "url": "" }, { "id": "8143232", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-HIV-184393", "participant_name": "GAG Polyprotein (P04591) [cytosol]", "crossref": [ { "id": "P04591", "database": "UniProt", "url": "" }, { "id": "6N3U", "database": "PDB", "url": "" }, { "id": "6ZDJ", "database": "PDB", "url": "" }, { "id": "1TSQ", "database": "PDB", "url": "" }, { "id": "1TSU", "database": "PDB", "url": "" }, { "id": "5NMH", "database": "PDB", "url": "" }, { "id": "5NMK", "database": "PDB", "url": "" }, { "id": "7ASH", "database": "PDB", "url": "" }, { "id": "6CQJ", "database": "PDB", "url": "" }, { "id": "6EC2", "database": "PDB", "url": "" }, { "id": "6ECN", "database": "PDB", "url": "" }, { "id": "6CPO", "database": "PDB", "url": "" }, { "id": "6ECO", "database": "PDB", "url": "" }, { "id": "5NMF", "database": "PDB", "url": "" }, { "id": "6N3J", "database": "PDB", "url": "" }, { "id": "5NMG", "database": "PDB", "url": "" }, { "id": "5INC", "database": "PDB", "url": "" }, { "id": "6CQQ", "database": "PDB", "url": "" }, { "id": "5IND", "database": "PDB", "url": "" }, { "id": "6CQR", "database": "PDB", "url": "" }, { "id": "NP_057850.1", "database": "RefSeq", "url": "" }, { "id": "6CPN", "database": "PDB", "url": "" }, { "id": "P04591", "database": "PRO", "url": "" }, { "id": "5NME", "database": "PDB", "url": "" }, { "id": "7ASL", "database": "PDB", "url": "" }, { "id": "5FJB", "database": "PDB", "url": "" }, { "id": "5I1R", "database": "PDB", "url": "" }, { "id": "7WJ2", "database": "PDB", "url": "" }, { "id": "6CQL", "database": "PDB", "url": "" }, { "id": "6CPL", "database": "PDB", "url": "" }, { "id": "6CQN", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HIV-184427", "participant_name": "N-myristoyl GAG (P04591) protein [cytosol]", "crossref": [ { "id": "5NME", "database": "PDB", "url": "" }, { "id": "7ASH", "database": "PDB", "url": "" }, { "id": "5NMG", "database": "PDB", "url": "" }, { "id": "7WJ2", "database": "PDB", "url": "" }, { "id": "6CPO", "database": "PDB", "url": "" }, { "id": "1TSQ", "database": "PDB", "url": "" }, { "id": "6CQR", "database": "PDB", "url": "" }, { "id": "6N3U", "database": "PDB", "url": "" }, { "id": "6CQQ", "database": "PDB", "url": "" }, { "id": "5FJB", "database": "PDB", "url": "" }, { "id": "6EC2", "database": "PDB", "url": "" }, { "id": "6CPL", "database": "PDB", "url": "" }, { "id": "5NMF", "database": "PDB", "url": "" }, { "id": "5NMH", "database": "PDB", "url": "" }, { "id": "6CPN", "database": "PDB", "url": "" }, { "id": "6CQN", "database": "PDB", "url": "" }, { "id": "6N3J", "database": "PDB", "url": "" }, { "id": "5NMK", "database": "PDB", "url": "" }, { "id": "P04591", "database": "PRO", "url": "" }, { "id": "6ZDJ", "database": "PDB", "url": "" }, { "id": "5IND", "database": "PDB", "url": "" }, { "id": "5I1R", "database": "PDB", "url": "" }, { "id": "6ECN", "database": "PDB", "url": "" }, { "id": "P04591", "database": "UniProt", "url": "" }, { "id": "6ECO", "database": "PDB", "url": "" }, { "id": "NP_057850.1", "database": "RefSeq", "url": "" }, { "id": "1TSU", "database": "PDB", "url": "" }, { "id": "6CQL", "database": "PDB", "url": "" }, { "id": "5INC", "database": "PDB", "url": "" }, { "id": "6CQJ", "database": "PDB", "url": "" }, { "id": "7ASL", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-2534062", "participant_name": "N-(C14:0)-GNAT1 [photoreceptor disc membrane]", "crossref": [ { "id": "3RBQ", "database": "PDB", "url": "" }, { "id": "ENSG00000114349", "database": "Ensembl", "url": "" }, { "id": "ENSG00000114349", "database": "OpenTargets", "url": "" }, { "id": "NP_653082.1", "database": "RefSeq", "url": "" }, { "id": "NP_000163.2", "database": "RefSeq", "url": "" }, { "id": "P11488", "database": "PRO", "url": "" }, { "id": "ENSP00000232461", "database": "Ensembl", "url": "" }, { "id": "P11488", "database": "UniProt", "url": "" }, { "id": "16148", "database": "Orphanet", "url": "" }, { "id": "ENSG00000114349-GNAT1", "database": "HPA", "url": "" }, { "id": "HMDBP02413", "database": "HMDB Protein", "url": "" }, { "id": "ENSP00000387555", "database": "Ensembl", "url": "" }, { "id": "P11488", "database": "GeneCards", "url": "" }, { "id": "ENST00000433068", "database": "Ensembl", "url": "" }, { "id": "ENST00000232461", "database": "Ensembl", "url": "" }, { "id": "P11488", "database": "Pharos - Targets", "url": "" } ] } ], "reaction_enzymes": [ { "uniprot_ac": "A0A8I5ZWZ4", "gene_name": "Nmt2", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein].", "evidence": [ { "id": "A0A8I5ZWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZWZ4" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "A0A8I5ZWZ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZWZ4" } ] } ] }, { "uniprot_ac": "O60551", "gene_name": "NMT2", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein].", "evidence": [ { "id": "O60551", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60551" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "O60551", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60551" } ] }, { "ec_number": "2.3.1.-", "activity": "", "evidence": [ { "id": "O60551", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60551" } ] } ] }, { "uniprot_ac": "O61613", "gene_name": "Nmt", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein].", "evidence": [ { "id": "O61613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61613" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "O61613", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61613" } ] } ] }, { "uniprot_ac": "O70310", "gene_name": "Nmt1", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein].", "evidence": [ { "id": "O70310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70310" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "O70310", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70310" } ] } ] }, { "uniprot_ac": "O70311", "gene_name": "Nmt2", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein].", "evidence": [ { "id": "O70311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70311" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "O70311", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70311" } ] } ] }, { "uniprot_ac": "P14743", "gene_name": "NMT1", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein].", "evidence": [ { "id": "P14743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14743" } ] }, { "ec_number": "2.3.1.97", "activity": "", "evidence": [ { "id": "P14743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14743" } ] } ] }, { "uniprot_ac": "P30419", "gene_name": "NMT1", "activity": [ { "ec_number": "2.3.1.97", "activity": "N-terminal glycyl-[protein] + tetradecanoyl-CoA = CoA + H(+) + N-tetradecanoylglycyl-[protein].", "evidence": [ { "id": "P30419", "database": "UniProtKB", "url": 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