{ "uniprot_canonical_ac": "O60502-1", "uniprot_ac": "O60502", "uniprot_id": "OGA_HUMAN", "mass": { "chemical_mass": 102915.0, "monoisotopic_mass": 102915.0 }, "refseq": { "ac": "NP_001135906", "name": "protein O-GlcNAcase isoform b", "summary": "The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, "gene_names": [ { "name": "OGA", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60502", "id": "O60502" }, { "name": "HEXC", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60502", "id": "O60502" }, { "name": "KIAA0679", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60502", "id": "O60502" }, { "name": "MEA5; MGEA5; NCOAT", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906", "id": "NP_001135906" }, { "name": "MEA5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60502", "id": "O60502" }, { "name": "MGEA5", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60502", "id": "O60502" }, { "name": "OGA", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906", "id": "NP_001135906" } ], "protein_names": [ { "name": "Protein O-GlcNAcase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60502" }, { "name": "3.2.1.169", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "Beta-N-acetylglucosaminidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "Beta-N-acetylhexosaminidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "Beta-hexosaminidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "Meningioma-expressed antigen 5", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "N-acetyl-beta-D-glucosaminidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "N-acetyl-beta-glucosaminidase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "NCOAT", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "Nuclear cytoplasmic O-GlcNAcase and acetyltransferase", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "OGA", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60502" }, { "name": "hyaluronidase in meningioma; bifunctional protein NCOAT; nuclear cytoplasmic O-GlcNAcase and acetyltransferase; meningioma-expressed antigen 5; meningioma expressed antigen 5 (hyaluronidase); beta-hexosaminidase; beta-N-acetylhexosaminidase; beta-N-acetylglucosaminidase; N-acetyl-beta-glucosaminidase; N-acetyl-beta-D-glucosaminidase; protein O-GlcNAcase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906", "id": "NP_001135906" }, { "name": "protein O-GlcNAcase isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906", "id": "NP_001135906" } ], "function": [ { "annotation": "Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, { "database": "PubMed", "id": "33310751", "url": "https://glygen.org/publication/PubMed/33310751" } ] }, { "annotation": "Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502#function" }, { "database": "PubMed", "id": "24088714", "url": "https://glygen.org/publication/PubMed/24088714" }, { "database": "PubMed", "id": "22365600", "url": "https://glygen.org/publication/PubMed/22365600" }, { "database": "PubMed", "id": "11788610", "url": "https://glygen.org/publication/PubMed/11788610" }, { "database": "PubMed", "id": "20673219", "url": "https://glygen.org/publication/PubMed/20673219" }, { "database": "PubMed", "id": "11148210", "url": "https://glygen.org/publication/PubMed/11148210" } ] }, { "annotation": "Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502#function" }, { "database": "PubMed", "id": "20673219", "url": "https://glygen.org/publication/PubMed/20673219" } ] }, { "annotation": "Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, { "database": "PubMed", "id": "37907462", "url": "https://glygen.org/publication/PubMed/37907462" } ] }, { "annotation": "Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, { "database": "PubMed", "id": "33333092", "url": "https://glygen.org/publication/PubMed/33333092" } ] }, { "annotation": "Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, { "database": "PubMed", "id": "36124999", "url": "https://glygen.org/publication/PubMed/36124999" } ] }, { "annotation": "Investigated this locus in Pima Indians who have the world's highest prevalence of NIDDM. Concluded that mutations in MGEA5 are unlikely to contribute to NIDDM in this population GeneRIF: Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, { "database": "PubMed", "id": "12359146", "url": "https://glygen.org/publication/PubMed/12359146" } ] }, { "annotation": "OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, { "database": "PubMed", "id": "34135314", "url": "https://glygen.org/publication/PubMed/34135314" } ] }, { "annotation": "The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" } ] }, { "annotation": "This protein is a cytosolic, neutral, O-GlcNAc specific hexosaminidase termed O-GlcNAcase.", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" }, { "database": "PubMed", "id": "11148210", "url": "https://glygen.org/publication/PubMed/11148210" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O60502", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O60502" }, { "id": "rs146955407", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146955407" }, { "id": "rs146955407", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146955407" }, { "id": "rs146955407", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs146955407" }, { "id": "rs146955407", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs146955407#frequency_tab" }, { "id": "rs146955407", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs146955407" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 398, "end_pos": 398, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: o-glyco-site-loss (S->N).", "chr_id": "10", "chr_pos": "101800244", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "S398", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs1369550569", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1369550569" }, { "id": "rs1369550569", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1369550569#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 399, "end_pos": 399, "sequence_org": "S", "sequence_mut": "G", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->G).", "chr_id": "10", "chr_pos": "101800242", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S399", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs924424846", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs924424846" }, { "id": "rs924424846", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs924424846#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 399, "end_pos": 399, "sequence_org": "S", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->I).", "chr_id": "10", "chr_pos": "101799455", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S399", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs924424846", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs924424846" }, { "id": "rs924424846", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs924424846#frequency_tab" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 399, "end_pos": 399, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->N).", "chr_id": "10", "chr_pos": "101799455", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S399", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1347022773", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1347022773" }, { "id": "rs1347022773", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1347022773" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 410, "end_pos": 410, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (S->R).", "chr_id": "10", "chr_pos": "101799421", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S410", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1454202637", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1454202637" }, { "id": "rs1454202637", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1454202637#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 413, "end_pos": 413, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DGT->NGT).", "chr_id": "10", "chr_pos": "101799414", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D413", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs776714346", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776714346" }, { "id": "rs776714346", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776714346" }, { "id": "rs776714346", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs776714346#frequency_tab" }, { "id": "rs776714346", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs776714346" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 481, "end_pos": 481, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDN->NDS).", "chr_id": "10", "chr_pos": "101799209", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N481", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O60502", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O60502" } ], "glycoeffect": [], "start_pos": 550, "end_pos": 550, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "V", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "10", "chr_pos": "101799002", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A550", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": 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"Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O60502", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60502" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60502", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60502" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60502" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "common_name": "Human" } ], "gene": [ { "name": "OGA", "url": "https://www.uniprot.org/uniprot/O60502", "locus": { "chromosome": "10", "start_pos": 101784443, "end_pos": 101818465, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000198408", "url": "https://www.ensembl.org/id/ENSG00000198408" } ] } } ], "crossref": [ { "id": "ENSG00000198408", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000198408", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O60502", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O60502", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "3.2.1.169", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.2.1.169&UniProtAcc=O60502", "database": 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"https://www.ebi.ac.uk/intact/interactors/id:O60502*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR011496", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011496", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR016181", "url": "https://www.ebi.ac.uk/interpro/entry/IPR016181", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017853", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017853", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:10724", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10724", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "604039", "url": "http://www.omim.org/entry/604039", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O60502", "url": "https://www.nextprot.org/entry/NX_O60502", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O60502", "url": 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"https://www.rcsb.org/structure/5UHP", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5UN8", "url": "https://www.rcsb.org/structure/5UN8", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5UN9", "url": "https://www.rcsb.org/structure/5UN9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VVO", "url": "https://www.rcsb.org/structure/5VVO", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VVT", "url": "https://www.rcsb.org/structure/5VVT", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VVU", "url": "https://www.rcsb.org/structure/5VVU", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VVV", "url": "https://www.rcsb.org/structure/5VVV", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5VVX", "url": "https://www.rcsb.org/structure/5VVX", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6HKI", "url": "https://www.rcsb.org/structure/6HKI", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6PM9", "url": "https://www.rcsb.org/structure/6PM9", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7OU6", "url": "https://www.rcsb.org/structure/7OU6", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7YEH", "url": "https://www.rcsb.org/structure/7YEH", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF07555", "url": "http://pfam.xfam.org/family/PF07555", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O60502", "url": "https://pharos.nih.gov/targets/O60502", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O60502", "url": "http://purl.obolibrary.org/obo/PR_O60502", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "48876", "url": "https://www.rhea-db.org/rhea/48876", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48892", "url": "https://www.rhea-db.org/rhea/48892", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "O60502", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "H7C3X0", "url": "https://www.uniprot.org/uniprot/H7C3X0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C3X0-1", "url": "https://www.uniprot.org/uniprot/H7C3X0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60502-1", "url": "https://www.uniprot.org/uniprot/O60502-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60502-2", "url": "https://www.uniprot.org/uniprot/O60502-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60502-3", "url": "https://www.uniprot.org/uniprot/O60502-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O60502-4", "url": "https://www.uniprot.org/uniprot/O60502-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL", "length": 916, "header": "sp|O60502-1|OGA_HUMAN Isoform 1 of Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2 CANONICAL=O60502-1" }, "isoforms": [ { "isoform_ac": "H7C3X0-1", "url": "", "sequence": { "sequence": "AAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRK", "length": 256, "header": "tr|H7C3X0-1|OGA_HUMAN Computationally mapped isoform of Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=1 CANONICAL=O60502-1" }, "locus": { "chromosome": "10", "start_pos": 101817866, "end_pos": 101803748, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000429860.1", "url": "https://www.ensembl.org/id/ENST00000429860.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000414235.1", "url": "https://www.ensembl.org/id/ENSP00000414235.1" } ] } }, { "isoform_ac": "O60502-1", "url": "", "sequence": { "sequence": "MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL", "length": 916, "header": "sp|O60502-1|OGA_HUMAN Isoform 1 of Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2 CANONICAL=O60502-1" }, "locus": { "chromosome": "10", "start_pos": 101818022, "end_pos": 101786454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000361464.8", "url": "https://www.ensembl.org/id/ENST00000361464.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000354850.3", "url": "https://www.ensembl.org/id/ENSP00000354850.3" } ] } }, { "isoform_ac": "O60502-2", "url": "", "sequence": { "sequence": "MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL", "length": 849, "header": "sp|O60502-2|OGA_HUMAN Isoform 2 of Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2 CANONICAL=O60502-1" }, "locus": { "chromosome": "10", "start_pos": 101818022, "end_pos": 101786454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000357797.9", "url": "https://www.ensembl.org/id/ENST00000357797.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000350445.4", "url": "https://www.ensembl.org/id/ENSP00000350445.4" } ] } }, { "isoform_ac": "O60502-3", "url": "", "sequence": { "sequence": "MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGRCTRNNLFSSNILSL", "length": 677, "header": "sp|O60502-3|OGA_HUMAN Isoform 3 of Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2 CANONICAL=O60502-1" }, "locus": { "chromosome": "10", "start_pos": 101818022, "end_pos": 101797933, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000370094.7", "url": "https://www.ensembl.org/id/ENST00000370094.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000359112.3", "url": "https://www.ensembl.org/id/ENSP00000359112.3" } ] } }, { "isoform_ac": "O60502-4", "url": "", "sequence": { "sequence": "MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMSRQVAHSGAKASVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKNDNQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL", "length": 863, "header": "sp|O60502-4|OGA_HUMAN Isoform 4 of Protein O-GlcNAcase OS=Homo sapiens OX=9606 GN=OGA PE=1 SV=2 CANONICAL=O60502-1" }, "locus": { "chromosome": "10", "start_pos": 101818022, "end_pos": 101786454, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000439817.5", "url": "https://www.ensembl.org/id/ENST00000439817.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000409973.1", "url": "https://www.ensembl.org/id/ENSP00000409973.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 398, "start_aa": "Ser", "end_pos": 398, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser398", "evidence": [ { "id": "O60502", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "34065225", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34065225" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "24995865", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24995865" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "16434389", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16434389" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "O60502", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60502" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "SSRQVAHSGAKASVVDGTPL", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 398, "start_aa": "Ser", "end_pos": 417, "end_aa": "Leu", "evidence": [ { "id": "O60502", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 399, "start_aa": "Ser", "end_pos": 399, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser399", "evidence": [ { "id": "O60502", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "34065225", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34065225" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "24995865", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24995865" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "16434389", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16434389" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "O60502", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60502" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 405, "start_aa": "Ser", "end_pos": 405, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser405", "evidence": [ { "id": "O60502", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "34065225", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34065225" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "24995865", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24995865" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "16434389", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16434389" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "O60502", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60502" } ] }, { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 405, "start_aa": "Ser", "end_pos": 405, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser405", "evidence": [ { "id": "O60502", "database": "UniCarbKB", "url": "" }, { "id": "25813380", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/25813380" }, { "id": "10.1074/mcp.M114.046862", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1074/mcp.M114.046862" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "G70994MS", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "", "start_pos": 405, "start_aa": "Ser", "end_pos": 405, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser405", "evidence": [ { "id": "GLY_000142", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000142" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 410, "start_aa": "Ser", "end_pos": 410, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser410", "evidence": [ { "id": "O60502", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "34065225", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34065225" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "24995865", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24995865" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "16434389", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16434389" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "O60502", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60502" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 415, "start_aa": "Thr", "end_pos": 415, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr415", "evidence": [ { "id": "O60502", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "id": "33214551", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/33214551" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "35138101", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35138101" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "26853435", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/26853435" }, { "id": "34065225", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34065225" }, { "id": "29351928", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29351928" }, { "id": "24995865", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24995865" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "16434389", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/16434389" }, { "id": "29485866", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29485866" }, { "id": "32119511", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32119511" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "30059200", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30059200" }, { "id": "O60502", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60502" } ] } ], "phosphorylation": [ { "start_pos": 364, "end_pos": 364, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O60502", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502" }, { "database": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" }, { "database": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" }, { "database": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" }, { "database": "PubMed", "id": 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Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.", "evidence": [ { "database": "UniCarbKB", "id": "O60502", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "Probing the O-Glycoproteome of Gastric Cancer Cell Lines for Biomarker Discovery", "journal": "Molecular & Cellular Proteomics", "date": "2015", "authors": "Campos D., Freitas D., Gomes J., Magalh\u00e3es A., Steentoft C., Gomes C., Vester-Christensen M. B., Ferreira J. A., Afonso L. P., Santos L. L., Pinto de Sousa J., Mandel U., Clausen H., Vakhrushev S. Y., Reis C. 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Biophys. Res. Commun.", "date": "2001", "authors": "Comtesse N, Maldener E, Meese E", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "reference": [ { "type": "PubMed", "id": "11341771", "url": "https://glygen.org/publication/PubMed/11341771" } ] }, { "title": "Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Wells L, Gao Y, Mahoney JA, Vosseller K, Chen C, Rosen A, Hart GW", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "reference": [ { "type": "PubMed", "id": "11788610", "url": "https://glygen.org/publication/PubMed/11788610" } ] }, { "title": "Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians.", "journal": "Molecular genetics and metabolism", "date": "2002", "authors": "Farook VS, Bogardus C, Prochazka M", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" } ], "reference": [ { "type": "PubMed", "id": "12359146", "url": "https://glygen.org/publication/PubMed/12359146" } ] }, { "title": "Large-scale characterization of HeLa cell nuclear phosphoproteins.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2004", "authors": "Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villen J, Li J, Cohn MA, Cantley LC, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "15302935", "url": "https://glygen.org/publication/PubMed/15302935" } ] }, { "title": "Phosphoproteomic analysis of the developing mouse brain.", "journal": "Molecular & cellular proteomics : MCP", "date": "2004", "authors": "Ballif BA, Villen J, Beausoleil SA, Schwartz D, Gygi SP", "evidence": [ { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "15345747", "url": "https://glygen.org/publication/PubMed/15345747" } ] }, { "title": "Recombinant O-GlcNAc transferase isoforms: identification of O-GlcNAcase, yes tyrosine kinase, and tau as isoform-specific substrates.", "journal": "Glycobiology", "date": "2006", "authors": "Lazarus BD, Love DC, Hanover JA", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "16434389", "url": "https://glygen.org/publication/PubMed/16434389" } ] }, { "title": "Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants.", "journal": "Biochemistry", "date": "2006", "authors": "Cetinbas N, Macauley MS, Stubbs KA, Drapala R, Vocadlo DJ", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "reference": [ { "type": "PubMed", "id": "16533067", "url": "https://glygen.org/publication/PubMed/16533067" } ] }, { "title": "Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis.", "journal": "The Journal of biological chemistry", "date": "2008", "authors": "Butkinaree C, Cheung WD, Park S, Park K, Barber M, Hart GW", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "reference": [ { "type": "PubMed", "id": "18586680", "url": "https://glygen.org/publication/PubMed/18586680" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" }, { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics.", "journal": "Journal of proteome research", "date": "2008", "authors": "Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, Pan KT, Chen JY, Khoo KH, Chen YJ", "evidence": [ { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "O60502-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" }, { "database": "iPTMnet", "id": "O60502", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" }, { "database": "iPTMnet", "id": 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Biokhimiia", "date": "2010-07", "authors": "Li Jing, Huang Cai-luan, Zhang Lian-wen, Lin Lin, Li Zhong-hua, Zhang Fu-wu, Wang Peng", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "reference": [ { "type": "PubMed", "id": "20673219", "url": "https://glygen.org/publication/PubMed/20673219" } ] }, { "title": "Human OGA binds substrates in a conserved peptide recognition groove.", "journal": "The Biochemical journal", "date": "2010", "authors": "Schimpl M, Schuttelkopf AW, Borodkin VS, van Aalten DM", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "reference": [ { "type": "PubMed", "id": "20863279", "url": "https://glygen.org/publication/PubMed/20863279" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" }, { "database": "iPTMnet", "id": "O60502", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.", "journal": "Science signaling", "date": "2011", "authors": "Carlson SM, Chouinard CR, Labadorf A, Lam CJ, Schmelzle K, Fraenkel E, White FM", "evidence": [ { "database": "iPTMnet", "id": "O60502", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60502" } ], "reference": [ { "type": "PubMed", "id": "22028470", "url": "https://glygen.org/publication/PubMed/22028470" } ] }, { "title": "Synergy of peptide and sugar in 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PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "database": "O-GlcNAc Atlas", "id": "O60502", "url": "https://oglcnac.org/atlas/detail/O60502" }, { "database": "GlyGen", "id": "GLY_000142", "url": "https://data.glygen.org/GLY_000142" } ], "reference": [ { "type": "PubMed", "id": "29351928", "url": "https://glygen.org/publication/PubMed/29351928" } ] }, { "title": "O-GlcNAc Transferase Recognizes Protein Substrates Using an Asparagine Ladder in the Tetratricopeptide Repeat (TPR) Superhelix.", "journal": "Journal of the American Chemical Society", "date": "2018", "authors": "Levine ZG, Fan C, Melicher MS, Orman M, Benjamin T, Walker S", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "29485866", "url": "https://glygen.org/publication/PubMed/29485866" } ] }, { "title": "Quantitative Profiling of Protein O-GlcNAcylation Sites by an Isotope-Tagged Cleavable Linker.", "journal": "ACS chemical biology", "date": "2018", "authors": "Qin K, Zhu Y, Qin W, Gao J, Shao X, Wang YL, Zhou W, Wang C, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "database": "O-GlcNAc Atlas", "id": "O60502", "url": "https://oglcnac.org/atlas/detail/O60502" } ], "reference": [ { "type": "PubMed", "id": "30059200", "url": "https://glygen.org/publication/PubMed/30059200" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" }, { "database": "O-GlcNAc Atlas", "id": "O60502", "url": "https://oglcnac.org/atlas/detail/O60502" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Engineering a Proximity-Directed O-GlcNAc Transferase for Selective Protein O-GlcNAcylation in Cells.", "journal": "ACS chemical biology", "date": "2020", "authors": "Ramirez DH, Aonbangkhen C, Wu HY, Naftaly JA, Tang S, O'Meara TR, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "32119511", "url": "https://glygen.org/publication/PubMed/32119511" } ] }, { "title": "Proteomic profiling and genome-wide mapping of O-GlcNAc chromatin-associated proteins reveal an O-GlcNAc-regulated genotoxic stress response.", "journal": "Nature communications", "date": "2020", "authors": "Liu Y, Chen Q, Zhang N, Zhang K, Dou T, Cao Y, Liu Y, Li K, Hao X, Xie X, Li W, Ren Y, Zhang J", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "33214551", "url": "https://glygen.org/publication/PubMed/33214551" } ] }, { "title": "Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.", "journal": "Gut", "date": "2021", "authors": "He X, Gao J, Peng L, Hu T, Wan Y, Zhou M, Zhen P, Cao H", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" } ], "reference": [ { "type": "PubMed", "id": "33310751", "url": "https://glygen.org/publication/PubMed/33310751" } ] }, { "title": "Elucidating the protein substrate recognition of O-GlcNAc transferase (OGT) toward O-GlcNAcase (OGA) using a GlcNAc electrophilic probe.", "journal": "International journal of biological macromolecules", "date": "2021", "authors": "Kositzke A, Fan D, Wang A, Li H, Worth M, Jiang J", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" } ], "reference": [ { "type": "PubMed", "id": "33333092", "url": "https://glygen.org/publication/PubMed/33333092" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Oxonium Ion Guided Analysis of Quantitative Proteomics Data Reveals Site-Specific O-Glycosylation of Anterior Gradient Protein 2 (AGR2).", "journal": "International journal of molecular sciences", "date": "2021", "authors": "Pirro M, Mohammed Y, de Ru AH, Janssen GMC, Tjokrodirijo RTN, Madunic K, Wuhrer M, van Veelen PA, Hensbergen PJ", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "34065225", "url": "https://glygen.org/publication/PubMed/34065225" } ] }, { "title": "OGA is associated with deglycosylation of NONO and the KU complex during DNA damage repair.", "journal": "Cell death & disease", "date": "2021", "authors": "Cui Y, Xie R, Zhang X, Liu Y, Hu Y, Li Y, Liu X, Yu X, Wu C", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" } ], "reference": [ { "type": "PubMed", "id": "34135314", "url": "https://glygen.org/publication/PubMed/34135314" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "Spatiotemporal Activation of Protein O-GlcNAcylation in Living Cells.", "journal": "Journal of the American Chemical Society", "date": "2022", "authors": "He J, Fan Z, Tian Y, Yang W, Zhou Y, Zhu Q, Zhang W, Qin W, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "35138101", "url": "https://glygen.org/publication/PubMed/35138101" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60502", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60502" } ], "reference": [ { "type": "PubMed", "id": "35254053", "url": "https://glygen.org/publication/PubMed/35254053" } ] }, { "title": "Inhibition of O-GlcNAcase Inhibits Hematopoietic and Leukemic Stem Cell Self-Renewal and Drives Dendritic Cell Differentiation via STAT3/5 Signaling.", "journal": "Stem cells (Dayton, Ohio)", "date": "2022-12-31", "authors": "Luanpitpong Sudjit, Rodboon Napachai, Samart Parinya, Janan Montira, Klaihmon Phatchanat, Lorthongpanich Chanchao, U-Pratya Yaowalak, Issaragrisil Surapol", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" } ], "reference": [ { "type": "PubMed", "id": "36124999", "url": "https://glygen.org/publication/PubMed/36124999" } ] }, { "title": "Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex.", "journal": "Nature communications", "date": "2023-10-31", "authors": "Lu Ping, Liu Yusong, He Maozhou, Cao Ting, Yang Mengquan, Qi Shutao, Yu Hongtao, Gao Haishan", "evidence": [ { "database": "RefSeq", "id": "NP_001135906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135906" } ], "reference": [ { "type": "PubMed", "id": "37907462", "url": "https://glygen.org/publication/PubMed/37907462" } ] }, { "title": "Novel immunogenic antigen homologous to hyaluronidase in meningioma.", "journal": "Hum. Mol. Genet.", "date": "1998", "authors": "Heckel D, Comtesse N, Brass N, Blin N, Zang KD, Meese E", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "reference": [ { "type": "PubMed", "id": "9811929", "url": "https://glygen.org/publication/PubMed/9811929" } ] } ], "pathway": [ { "id": "hsa:10724", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10724", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8VIJ5-1", "protein_name": "Protein O-GlcNAcase", "gene_name": "Oga", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSGAGAAAGTGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPSVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSALTKEEEKKQPDEEPMDMVVEKQEESEHKSDNQILTEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCINDIAPMQTDEQANKEQFVPGPNEKPLYAAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL", "length": 916 }, "evidence": [ { "id": "45928240", "url": "http://www.informatics.jax.org/homology/45928240", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9EQQ9-1", "protein_name": "Protein O-GlcNAcase", "gene_name": "Oga", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MVQKESQAALEERESERNANPAAASGASLEQSVAPAPGEDNPSGAGAAAVVGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSVLTKEEEKKQPDEEPMDMVVEKQEEAEHKNDNQILTEIVEAKMAEELRPMDTDKESMAESKSPEMSMQEDCIPDVAPMQTDEQTQKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGFPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL", "length": 916 }, "evidence": [ { "id": "45928240", "url": "http://www.informatics.jax.org/homology/45928240", "database": "MGI" }, { "id": "O60502", "url": "https://omabrowser.org/oma/group/O60502/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "beta-N-acetylglucosaminidase activity", "id": "GO:0016231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016231", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "identical protein binding", "id": "GO:0042802", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042802", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "hyalurononglucosaminidase activity", "id": "GO:0004415", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004415", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "id": "GO:0102166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102166", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity", "id": "GO:0102167", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102167", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity", "id": "GO:0102571", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102571", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "organonitrogen compound metabolic process", "id": "GO:1901564", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901564", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "primary metabolic process", "id": "GO:0044238", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044238", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "N-acetylglucosamine metabolic process", "id": "GO:0006044", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006044", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "protein deglycosylation", "id": "GO:0006517", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006517", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "glycoprotein metabolic process", "id": "GO:0009100", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009100", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "glycoprotein catabolic process", "id": "GO:0006516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006516", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 227, "end_pos": 229, "annotation": "n_glycosylation_sequon" }, { "start_pos": 424, "end_pos": 426, "annotation": "n_glycosylation_sequon" }, { "start_pos": 588, "end_pos": 590, "annotation": "n_glycosylation_sequon" }, { "start_pos": 633, "end_pos": 635, "annotation": "n_glycosylation_sequon" }, { "start_pos": 871, "end_pos": 873, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.", "evidence": [ { "database": "UniProtKB", "id": "O60502", "url": "https://www.uniprot.org/uniprot/O60502" }, { "database": "PubMed", "id": "11788610", "url": "https://glygen.org/publication/PubMed/11788610" }, { "database": "PubMed", "id": "18586680", "url": "https://glygen.org/publication/PubMed/18586680" } ] } ], "interactions": [], "reactions": [ { "id": "48876", "name": "", "equation": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VIJ5-1", "O60502-1", "Q9EQQ9-1" ], "evidence": [ { "id": "48876", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48876" } ] }, { "id": "48892", "name": "", "equation": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + H2O = L-threonyl-[protein] + N-acetyl-D-glucosamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8VIJ5-1", "O60502-1", "Q9EQQ9-1" ], "evidence": [ { "id": "48892", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48892" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O60502", "gene_name": "OGA", "activity": [ { "ec_number": "3.2.1.169", "activity": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine.", "evidence": [ { "id": "O60502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60502" } ] }, { "ec_number": "3.2.1.169", "activity": "", "evidence": [ { "id": "O60502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60502" } ] } ] }, { "uniprot_ac": "Q8VIJ5", "gene_name": "Oga", "activity": [ { "ec_number": "3.2.1.169", "activity": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine.", "evidence": [ { "id": "Q8VIJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIJ5" } ] }, { "ec_number": "3.2.1.169", "activity": "", "evidence": [ { "id": "Q8VIJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VIJ5" } ] } ] }, { "uniprot_ac": "Q9EQQ9", "gene_name": "Oga", "activity": [ { "ec_number": "3.2.1.169", "activity": "3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + H2O = L-seryl-[protein] + N-acetyl-D-glucosamine.", "evidence": [ { "id": "Q9EQQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQQ9" } ] }, { "ec_number": "3.2.1.169", "activity": "", "evidence": [ { "id": "Q9EQQ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9EQQ9" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 398, 399, 405, 410, 415 ], "snv_sites": [ 398, 399, 410, 413, 481, 550, 845 ], "glycation_sites": [], "phosphorylation_sites": [ 364, 709, 859, 867, 873 ], "sequon_annotation_sites": [ { "start_pos": 227, "end_pos": 229 }, { "start_pos": 424, "end_pos": 426 }, { "start_pos": 588, "end_pos": 590 }, { "start_pos": 633, "end_pos": 635 }, { "start_pos": 871, "end_pos": 873 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 3 }, { "field": "o_linked_glycan_sites", "count": 6 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 8 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 3 }, { "field": "o_linked_glycan_sites", "count": 6 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 7 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 50 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }