{ "uniprot_canonical_ac": "O60296-1", "uniprot_ac": "O60296", "uniprot_id": "TRAK2_HUMAN", "mass": { "chemical_mass": 101419.0, "monoisotopic_mass": 101419.0 }, "refseq": { "ac": "NP_055864", "name": "trafficking kinesin-binding protein 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" }, "gene_names": [ { "name": "TRAK2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60296", "id": "O60296" }, { "name": "ALS2CR3; CALS-C; GRIF-1; GRIF1; MILT2; OIP98", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864", "id": "NP_055864" }, { "name": "ALS2CR3", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60296", "id": "O60296" }, { "name": "KIAA0549", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60296", "id": "O60296" }, { "name": "TRAK2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864", "id": "NP_055864" } ], "protein_names": [ { "name": "Trafficking kinesin-binding protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60296" }, { "name": "Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60296" }, { "name": "amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein; milton homolog 2; trafficking protein, kinesin binding 2; gamma-aminobutyric acid(A) receptor-interacting factor; O-linked N-acetylglucosamine transferase interacting protein 98", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864", "id": "NP_055864" }, { "name": "trafficking kinesin-binding protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864", "id": "NP_055864" } ], "function": [ { "annotation": "Full-length APC promotes assembly of the Miro-1/Milton-2 complex.", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" }, { "database": "PubMed", "id": "26658612", "url": "https://glygen.org/publication/PubMed/26658612" } ] }, { "annotation": "Identification, molecular cloning and characterization", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" }, { "database": "PubMed", "id": "12034717", "url": "https://glygen.org/publication/PubMed/12034717" } ] }, { "annotation": "May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR.", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296#function" } ] }, { "annotation": "MiR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers.", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" }, { "database": "PubMed", "id": "32267991", "url": "https://glygen.org/publication/PubMed/32267991" } ] }, { "annotation": "Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" }, { "database": "PubMed", "id": "34321481", "url": "https://glygen.org/publication/PubMed/34321481" } ] }, { "annotation": "TRAK2 is a novel regulator of LXR-mediated ABCA1 expression, cholesterol efflux, and HDL biogenesis. TRAK2 may therefore be an important target in the development of anti-atherosclerotic therapies.", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" }, { "database": "PubMed", "id": "28655204", "url": "https://glygen.org/publication/PubMed/28655204" } ] }, { "annotation": "This study showed that the TRAK2 was more prevalent in dendrites of hippocampal neurons. In cortical neurons, TRAK2 was equally distributed between axons and dendrites.", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" }, { "database": "PubMed", "id": "25653102", "url": "https://glygen.org/publication/PubMed/25653102" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs774671190", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774671190" }, { "id": "rs774671190", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs774671190" }, { "id": "rs774671190", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs774671190#frequency_tab" }, { "id": "rs774671190", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs774671190" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 185, "end_pos": 185, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SET->NET).", "chr_id": "2", "chr_pos": "201398281", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S185", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs372738496", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372738496" }, { "id": "rs372738496", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs372738496" }, { "id": "rs372738496", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs372738496#frequency_tab" }, { "id": "rs372738496", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs372738496" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 187, "end_pos": 187, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TDS->NDS).", "chr_id": "2", "chr_pos": "201398275", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T187", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1299040907", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1299040907" }, { "id": "rs1299040907", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1299040907#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 202, "end_pos": 202, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SLS->NLS).", "chr_id": "2", "chr_pos": "201398230", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S202", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1347417591", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1347417591" }, { "id": "rs1347417591", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1347417591#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 22, "end_pos": 22, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSN->NSS).", "chr_id": "2", "chr_pos": "201420443", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N22", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1239211007", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1239211007" }, { "id": "rs1239211007", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1239211007#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 24, "end_pos": 24, "sequence_org": "R", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NHR->NHT).", "chr_id": "2", "chr_pos": "201420437", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R24", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs758308661", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs758308661" }, { "id": "rs758308661", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs758308661" }, { "id": "rs758308661", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs758308661#frequency_tab" }, { "id": "rs758308661", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs758308661" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 28, "end_pos": 28, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SIT->NIT).", "chr_id": "2", "chr_pos": "201420425", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S28", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O60296", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O60296" } ], "glycoeffect": [], "start_pos": 351, "end_pos": 351, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": "C", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3). In dbSNP: rs756661916.", "chr_id": "2", "chr_pos": "201392971", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "R351", "disease": [ { "disease_id": "DOID:1319", "recommended_name": { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain cancer", "description": "A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain." }, "synonyms": [ { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "BT - Brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "adult malignant brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "brain neoplasm, adult", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant brain tumour", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of Brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "malignant tumor of adult brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain neoplasm", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary brain tumor", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "primary malignant neoplasm of brain", "description": "" }, { "id": "DOID:1319", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1319", "name": "tumor of the Brain", "description": "" } ] }, { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] }, { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1207132739", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1207132739" }, { "id": "rs1207132739", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1207132739#frequency_tab" }, { "id": "rs1207132739", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1207132739" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 436, "end_pos": 436, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IMT->NMT).", "chr_id": "2", "chr_pos": "201389390", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I436", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1248526090", 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passed 1 out of 1 filters: o-glyco-site-loss (T->R).", "chr_id": "2", "chr_pos": "201386220", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T654", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs142149505", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142149505" }, { "id": "rs142149505", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs142149505" }, { "id": "rs142149505", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142149505" }, { "id": "rs142149505", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs142149505#frequency_tab" }, { "id": "rs142149505", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs142149505" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 657, "end_pos": 657, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 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kinesin-binding protein 2 OS=Homo sapiens OX=9606 GN=TRAK2 PE=1 SV=2 CANONICAL=O60296-1" }, "locus": { "chromosome": "2", "start_pos": 201420507, "end_pos": 201380546, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000332624.8", "url": "https://www.ensembl.org/id/ENST00000332624.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000328875.3", "url": "https://www.ensembl.org/id/ENSP00000328875.3" } ] } }, { "isoform_ac": "O60296-2", "url": "", "sequence": { "sequence": "MSQSQNAIFTSPTGEENLMNSNHRDSESITDVCSNEDLPEVELVSLLEEQLPQYRLKVDTLFLYENQDWTQSPHQRQHASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLKELEEENMALRSKACHIKTETVTYEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRYQEELSSLLSQIVDLQHKLKEVGLFIHSTDIC", "length": 311, "header": "sp|O60296-2|TRAK2_HUMAN Isoform 2 of Trafficking kinesin-binding protein 2 OS=Homo sapiens OX=9606 GN=TRAK2 PE=1 SV=2 CANONICAL=O60296-1" }, "locus": { "chromosome": "2", "start_pos": 201420507, "end_pos": 201395281, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000430254.1", "url": "https://www.ensembl.org/id/ENST00000430254.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000409333.1", "url": "https://www.ensembl.org/id/ENSP00000409333.1" } ] } }, { "isoform_ac": "Q53RS6-1", "url": "", "sequence": { "sequence": "MSQSQNAIFTSPTGEENLMNSNHRDSESIT", "length": 30, "header": "tr|Q53RS6-1|Q53RS6_HUMAN Computationally mapped isoform of Uncharacterized protein ALS2CR3 OS=Homo sapiens OX=9606 GN=TRAK2 PE=4 SV=1 CANONICAL=O60296-1" }, "locus": { "chromosome": "2", "start_pos": 201420507, "end_pos": 201420418, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000440597.1", "url": "https://www.ensembl.org/id/ENST00000440597.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000388254.1", "url": "https://www.ensembl.org/id/ENSP00000388254.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 533, "start_aa": "Ser", "end_pos": 533, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser533", "evidence": [ { "id": "O60296", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60296" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 639, "start_aa": "Thr", "end_pos": 639, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr639", "evidence": [ { "id": "O60296", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60296" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 647, "start_aa": "Thr", "end_pos": 647, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr647", "evidence": [ { "id": "O60296", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60296" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "O60296", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60296" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 648, "start_aa": "Ser", "end_pos": 648, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser648", "evidence": [ { "id": "O60296", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60296" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 654, "start_aa": "Thr", "end_pos": 654, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr654", "evidence": [ { "id": "O60296", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60296" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 657, "start_aa": "Thr", "end_pos": 657, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr657", "evidence": [ { "id": "O60296", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60296" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "phosphorylation": [ { "start_pos": 280, "end_pos": 280, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60296", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60296" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ], "site_lbl": "Tyr280" }, { "start_pos": 285, "end_pos": 285, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O60296", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60296" }, { "database": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ], "site_lbl": "Ser285" }, { "start_pos": 420, "end_pos": 420, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O60296", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60296" } ], "site_lbl": "Ser420" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2.", "journal": "Genomics", "date": "2001", "authors": "Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "reference": [ { "type": "PubMed", "id": "11161814", "url": "https://glygen.org/publication/PubMed/11161814" } ] }, { "title": "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Beck M, Brickley K, Wilkinson HL, Sharma S, Smith M, Chazot PL, Pollard S, Stephenson FA", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" } ], "reference": [ { "type": "PubMed", "id": "12034717", "url": "https://glygen.org/publication/PubMed/12034717" } ] }, { "title": "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.", "journal": "Biochem. Biophys. Res. Commun.", "date": "2006", "authors": "Fransson S, Ruusala A, Aspenstrom P", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" }, { "database": "Reactome", "id": "R-HSA-9013425", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013425" } ], "reference": [ { "type": "PubMed", "id": "16630562", "url": "https://glygen.org/publication/PubMed/16630562" } ] }, { "title": "Phosphoproteome analysis of the human Chang liver cells using SCX and a complementary mass spectrometric strategy.", "journal": "Proteomics", "date": "2008", "authors": "Sui S, Wang J, Yang B, Song L, Zhang J, Chen M, Liu J, Lu Z, Cai Y, Chen S, Bi W, Zhu Y, He F, Qian X", "evidence": [ { "database": "iPTMnet", "id": "O60296-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60296-1" } ], "reference": [ { "type": "PubMed", "id": "18491316", "url": "https://glygen.org/publication/PubMed/18491316" } ] }, { "title": "GTPase dependent recruitment of Grif-1 by Miro1 regulates mitochondrial trafficking in hippocampal neurons.", "journal": "Molecular and cellular neurosciences", "date": "2009", "authors": "MacAskill AF, Brickley K, Stephenson FA, Kittler JT", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013425", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013425" } ], "reference": [ { "type": "PubMed", "id": "19103291", "url": "https://glygen.org/publication/PubMed/19103291" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" }, { "database": "iPTMnet", "id": "O60296", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60296" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons.", "journal": "Journal of neuroscience research", "date": "2015", "authors": "Loss O, Stephenson FA", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" } ], "reference": [ { "type": "PubMed", "id": "25653102", "url": "https://glygen.org/publication/PubMed/25653102" } ] }, { "title": "APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.", "journal": "Molecular biology of the cell", "date": "2016", "authors": "Mills KM, Brocardo MG, Henderson BR", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" } ], "reference": [ { "type": "PubMed", "id": "26658612", "url": "https://glygen.org/publication/PubMed/26658612" } ] }, { "title": "TRAK2, a novel regulator of ABCA1 expression, cholesterol efflux and HDL biogenesis.", "journal": "European heart journal", "date": "2017", "authors": "Lake NJ, Taylor RL, Trahair H, Harikrishnan KN, Curran JE, Almeida M, Kulkarni H, Mukhamedova N, Hoang A, Low H, Murphy AJ, Johnson MP, Dyer TD, Mahaney MC, Goring HHH, Moses EK, Sviridov D, Blangero J, Jowett JBM, Bozaoglu K", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" } ], "reference": [ { "type": "PubMed", "id": "28655204", "url": "https://glygen.org/publication/PubMed/28655204" } ] }, { "title": "MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca(2+) Stress.", "journal": "Cell reports", "date": "2018", "authors": "Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves SL, Jana F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen WJ, Rajan S, Shanmughapriya S, Caplan J, Prosser BL, Gill DL, Stathopulos PB, Gallo G, Chan DC, Mishra P, Madesh M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013419", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013419" } ], "reference": [ { "type": "PubMed", "id": "29694881", "url": "https://glygen.org/publication/PubMed/29694881" } ] }, { "title": "Identification of Miro1 and Miro2 as mitochondrial receptors for myosin XIX.", "journal": "Journal of cell science", "date": "2018", "authors": "Oeding SJ, Majstrowicz K, Hu XP, Schwarz V, Freitag A, Honnert U, Nikolaus P, Bahler M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013425", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013425" } ], "reference": [ { "type": "PubMed", "id": "30111583", "url": "https://glygen.org/publication/PubMed/30111583" } ] }, { "title": "Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism.", "journal": "International journal of molecular sciences", "date": "2018", "authors": "Peters DT, Kay L, Eswaran J, Lakey JH, Soundararajan M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013425", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013425" } ], "reference": [ { "type": "PubMed", "id": "30513825", "url": "https://glygen.org/publication/PubMed/30513825" } ] }, { "title": "The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes.", "journal": "Cytoskeleton (Hoboken, N.J.)", "date": "2020", "authors": "Bocanegra JL, Fujita BM, Melton NR, Cowan JM, Schinski EL, Tamir TY, Major MB, Quintero OA", "evidence": [ { "database": "Reactome", "id": "R-HSA-9013419", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9013419" } ], "reference": [ { "type": "PubMed", "id": "31479585", "url": "https://glygen.org/publication/PubMed/31479585" } ] }, { "title": "miR-487b and TRAK2 that form an axis to regulate the aggressiveness of osteosarcoma, are potential therapeutic targets and prognostic biomarkers.", "journal": "Journal of biochemical and molecular toxicology", "date": "2020", "authors": "Wang F, Ye BG, Liu JZ, Kong DL", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" } ], "reference": [ { "type": "PubMed", "id": "32267991", "url": "https://glygen.org/publication/PubMed/32267991" } ] }, { "title": "Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Maynard JC, Chalkley RJ", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O60296", "url": "https://oglcnac.org/atlas/detail/O60296" } ], "reference": [ { "type": "PubMed", "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60296", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60296" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors.", "journal": "Nature communications", "date": "2021", "authors": "Fenton AR, Jongens TA, Holzbaur ELF", "evidence": [ { "database": "RefSeq", "id": "NP_055864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055864" } ], "reference": [ { "type": "PubMed", "id": "34321481", "url": "https://glygen.org/publication/PubMed/34321481" } ] }, { "title": "Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis.", "journal": "Angewandte Chemie (International ed. in English)", "date": "2022", "authors": "Chen Y, Tang F, Qin H, Yue X, Nie Y, Huang W, Ye M", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60296", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60296" } ], "reference": [ { "type": "PubMed", "id": "35289036", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60296", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60296" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "pathway": [ { "id": "hsa:66008", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:66008", "resource": "KEGG 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"MSQSQNAIFKSRTGEANLMSSNHRDSESITDVCSNEDLPEVELVNLLEEQLPQYKLRVDSLFLYENQDWAQSSHQQQDAPETLSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNEALEEQLGQAFDQVNQLQHELSKKDELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLDMLHEKLRELEEENMALRSKACHIKTETFTYEEKEQQLVNDCVKELRETNAQMSRMTEELSGKSDELLRYQEEISSLLSQIVDLQHKLKEHVIEKEELRLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKELRSKSGPSAHLCFSQSYGVFTGESLAAEIEGTMRKKLSLDEESVSKQKAQQKRVFDTVKVANDTRGRSVTFPVLLPIPGSNRSSVIMTAKPFESGVQPAEDKTLLSPGGSTEVPGNSQPTNPPGSPEDSDLATALHRLSLRRQNYLSEKQFFAEEWERKIQILAEQEEEVSSCDAPTENLASVCTDQSETTDLGSASCLRGFMPEKLQIVKPLEGSQTLHHWQQLAQPNLGTILDPRPGVITKGFTQVPKDVVYHISDLEEDEEEGITFQVQQPLQLEQKPALPTPVTGIFLPPMTSAGGPGTVATSNPGKCLSFTNSTFTFTTCRILHPSDITQVTPSSGFPSLACGSSASSSSNTAVNSPAASYRLSIGESITNRRDSTITFSSTRSLAKLLQERGISAKVYHSPASENPLLQPCPKALATPSTPPNSPAQSPCSSPLPFEPRVHVSENFLASRPAETFLQEMYGLRPSRAPPDVGQLKMNLVDRLKRLGIARVVKTPDPQENGKSREAEMGLQKPDPAVYLNSGGSLLCGLRRNQSLPVMMGSFGAPVCTTSPKMGILKED", "length": 913 }, "evidence": [ { "id": "45931393", "url": "http://www.informatics.jax.org/homology/45931393", "database": "MGI" }, { "id": "O60296", "url": "https://omabrowser.org/oma/group/O60296/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q8R2H7-1", "protein_name": "Trafficking kinesin-binding protein 2", "gene_name": "Trak2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSLSQNAIFKSQTGEENLMSSNHRDSESITDVCSNEDLPEVELVNLLEEQLPQYKLRVDSLFLYENQDWSQSSHQQQDASETLSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLAERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELSKKEELLRIVSIASEESETDSSCSTPLRFNESFSLSQGLLQLDMMHEKLKELEEENMALRSKACHIKTETFTYEEKEQKLINDCVNELRETNAQMSRMTEELSGKSDELLRYQEEISSLLSQIVDLQHKLKEHVIEKEELRLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKELRNKAGPSAHLCFSQAYGVFAGESLAAEIEGTMRKKLSLDEESVFKQKAQQKRVFDTVKVANDTRGRSVTFPVLLPIPGSNRSSVIMTAKPFESGVQQTEDKTLPNQGSSTEVPGNSHPRDPPGLPEDSDLATALHRLSLRRQNYLSEKQFFAEEWERKLQILAEQEEEVSSCEALTENLASFCTDQSETTELGSAGCLRGFMPEKLQIVKPLEGSQTLHHWQQLAQPNLGTILDPRPGVITKGFTQMPKDAVYHISDLEEDEEVGITFQVQQPLQLEQKPAPPPPVTGIFLPPMTSAGGPVSVATSNPGKCLSFTNSTFTFTTCRILHPSDITQVTPSSGFPSLSCGSSAGSASNTAVNSPAASYRLSIGESITNRRDSTITFSSTRSLAKLLQERGISAKVYHSPASENPLLQLRPKALATPSTPPNSPSQSPCSSPVPFEPRVHVSENFLASRPAETFLQEMYGLRPSRAPPDVGQLKMNLVDRLKRLGIARVVKTPVPRENGKSREAEMGLQKPDSAVYLNSGGSLLGGLRRNQSLPVMMGSFGAPVCTTSPKMGILKED", "length": 913 }, "evidence": [ { "id": "45931393", "url": "http://www.informatics.jax.org/homology/45931393", "database": "MGI" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "signaling receptor binding", "id": "GO:0005102", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005102", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "myosin binding", "id": "GO:0017022", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017022", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "GABA receptor binding", "id": "GO:0050811", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050811", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "dendrite", "id": "GO:0030425", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "dendrite cytoplasm", "id": "GO:0032839", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032839", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "axon cytoplasm", "id": "GO:1904115", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1904115", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "protein targeting", "id": "GO:0006605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006605", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "mitochondrion distribution", "id": "GO:0048311", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048311", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "vesicle transport along microtubule", "id": "GO:0047496", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047496", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "anterograde axonal transport of mitochondrion", "id": "GO:0098957", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098957", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" }, { "name": "anterograde dendritic transport of mitochondrion", "id": "GO:0098972", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0098972", "evidence": [ { "database": "UniProtKB", "id": "O60296", "url": "https://www.uniprot.org/uniprot/O60296" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 147, "end_pos": 149, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 412, "end_pos": 414, "annotation": "n_glycosylation_sequon" }, { "start_pos": 431, "end_pos": 433, "annotation": "n_glycosylation_sequon" }, { "start_pos": 668, "end_pos": 670, "annotation": "n_glycosylation_sequon" }, { "start_pos": 887, "end_pos": 889, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 533, 639, 647, 648, 654, 657 ], "snv_sites": [ 22, 24, 28, 185, 187, 202, 351, 436, 546, 647, 654, 657, 701, 709, 736 ], "glycation_sites": [], "phosphorylation_sites": [ 280, 285, 420 ], "sequon_annotation_sites": [ { "start_pos": 147, "end_pos": 149 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 412, "end_pos": 414 }, { "start_pos": 431, "end_pos": 433 }, { "start_pos": 668, "end_pos": 670 }, { "start_pos": 887, "end_pos": 889 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 6 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 6 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 16 }, { "field": "total_sites", "count": 15 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 15 }, { "field": "total_sites", "count": 14 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 19 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }