{ "uniprot_canonical_ac": "O60291-1", "uniprot_ac": "O60291", "uniprot_id": "MGRN1_HUMAN", "mass": { "chemical_mass": 60753.0, "monoisotopic_mass": 60753.0 }, "refseq": { "ac": "NP_001135761", "name": "E3 ubiquitin-protein ligase MGRN1 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" }, "gene_names": [ { "name": "MGRN1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60291", "id": "O60291" }, { "name": "KIAA0544", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60291", "id": "O60291" }, { "name": "MGRN1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761", "id": "NP_001135761" }, { "name": "RNF156", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761", "id": "NP_001135761" }, { "name": "RNF156", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60291", "id": "O60291" } ], "protein_names": [ { "name": "E3 ubiquitin-protein ligase MGRN1", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60291" }, { "name": "2.3.2.27", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60291" }, { "name": "E3 ubiquitin-protein ligase MGRN1 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761", "id": "NP_001135761" }, { "name": "Mahogunin RING finger protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60291" }, { "name": "RING finger protein 156", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60291" }, { "name": "RING-type E3 ubiquitin transferase MGRN1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60291" }, { "name": "probable E3 ubiquitin-protein ligase MGRN1; RING finger protein 156; mahogunin RING finger protein 1; mahogunin ring finger 1, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase MGRN1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761", "id": "NP_001135761" } ], "function": [ { "annotation": "A role for Mahogunin in a proteasome-independent ubiquitylation pathway: TSG101 is a specific Mahogunin substrate", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" }, { "database": "PubMed", "id": "17229889", "url": "https://glygen.org/publication/PubMed/17229889" } ] }, { "annotation": "E3 ubiquitin ligase.", "evidence": [ { "database": "UniProtKB", "id": "B4DR12", "url": "https://www.uniprot.org/uniprot/B4DR12#function" }, { "database": "UniProtKB", "id": "RU369081", "url": "https://www.uniprot.org/uniprot/RU369081#function" }, { "database": "UniProtKB", "id": "K7EPJ5", "url": "https://www.uniprot.org/uniprot/K7EPJ5#function" }, { "database": "UniProtKB", "id": "K7EJN3", "url": "https://www.uniprot.org/uniprot/K7EJN3#function" }, { "database": "UniProtKB", "id": "K7ERA1", "url": "https://www.uniprot.org/uniprot/K7ERA1#function" }, { "database": "UniProtKB", "id": "K7EIM7", "url": "https://www.uniprot.org/uniprot/K7EIM7#function" } ] }, { "annotation": "E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291#function" }, { "database": "UniProtKB", "id": "Q9D074", "url": "https://www.uniprot.org/uniprot/Q9D074#function" }, { "database": "PubMed", "id": "19703557", "url": "https://glygen.org/publication/PubMed/19703557" }, { "database": "PubMed", "id": "19737927", "url": "https://glygen.org/publication/PubMed/19737927" }, { "database": "PubMed", "id": "17229889", "url": "https://glygen.org/publication/PubMed/17229889" } ] }, { "annotation": "In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to MGRN1 as the responsible E3-ligase.", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" }, { "database": "PubMed", "id": "28947386", "url": "https://glygen.org/publication/PubMed/28947386" } ] }, { "annotation": "MGRN1 depletion promotes intercellular adhesion in melanoma by upregulation of E-cadherin and inhibition of CDC42.", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" }, { "database": "PubMed", "id": "38008393", "url": "https://glygen.org/publication/PubMed/38008393" } ] }, { "annotation": "Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" }, { "database": "PubMed", "id": "34921635", "url": "https://glygen.org/publication/PubMed/34921635" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" }, { "database": "PubMed", "id": "19320733", "url": "https://glygen.org/publication/PubMed/19320733" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 406, "end_pos": 409, "sequence_org": "PSAP", "sequence_mut": "ASAA", "comment": "Loss of TSG101-binding and drastic reduction of TSG101-ubiquitination.", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" }, { "database": "PubMed", "id": "17229889", "url": "https://glygen.org/publication/PubMed/17229889" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "84.03", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "71.4", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "83.35", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "76.21", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "91.12", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "84.4", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "75.98", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "85.8", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "90.41", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "77.43", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "87.51", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.05", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "89.17", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000102858", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000102858" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O60291", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60291" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O60291", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60291" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { 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"name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { 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"" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60291", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60291" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60291" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLQL", "length": 320, "header": "tr|B4DR12-1|MGRN1_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase MGRN1 OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=1 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4681554, "end_pos": 4624961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000536343.5", "url": "https://www.ensembl.org/id/ENST00000536343.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000443810.1", "url": "https://www.ensembl.org/id/ENSP00000443810.1" } ] } }, { "isoform_ac": "K7EIM7-1", "url": "", "sequence": { "sequence": "XFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDAVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPAS", "length": 332, "header": "tr|K7EIM7-1|K7EIM7_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=1 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4680067, "end_pos": 4650387, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590790.5", "url": "https://www.ensembl.org/id/ENST00000590790.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000464811.1", "url": "https://www.ensembl.org/id/ENSP00000464811.1" } ] } }, { "isoform_ac": "K7EJN3-1", "url": "", "sequence": { "sequence": "EKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQHYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSD", "length": 166, "header": "tr|K7EJN3-1|K7EJN3_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=1 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4673554, "end_pos": 4650400, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000593224.1", "url": "https://www.ensembl.org/id/ENST00000593224.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000465249.1", "url": "https://www.ensembl.org/id/ENSP00000465249.1" } ] } }, { "isoform_ac": "K7EPJ5-1", "url": "", "sequence": { "sequence": "MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKISWKVSQARFIMASGPRTTGAAPRGGSGAPGRASPQPREPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPGRPTSMETAHGLATTS", "length": 594, "header": "tr|K7EPJ5-1|MGRN1_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase MGRN1 OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=1 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4688842, "end_pos": 4624961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000587747.5", "url": "https://www.ensembl.org/id/ENST00000587747.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000467414.1", "url": "https://www.ensembl.org/id/ENSP00000467414.1" } ] } }, { "isoform_ac": "K7ERA1-1", "url": "", "sequence": { "sequence": "MGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDE", "length": 149, "header": "tr|K7ERA1-1|K7ERA1_HUMAN Computationally mapped isoform of E3 ubiquitin-protein ligase OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=1 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4657363, "end_pos": 4650391, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000591895.5", "url": "https://www.ensembl.org/id/ENST00000591895.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468171.1", "url": "https://www.ensembl.org/id/ENSP00000468171.1" } ] } }, { "isoform_ac": "O60291-1", "url": "", "sequence": { "sequence": "MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSVGIDE", "length": 552, "header": "sp|O60291-1|MGRN1_HUMAN Isoform 1 of E3 ubiquitin-protein ligase MGRN1 OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=2 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4686296, "end_pos": 4624961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000399577.9", "url": "https://www.ensembl.org/id/ENST00000399577.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000382487.4", "url": "https://www.ensembl.org/id/ENSP00000382487.4" } ] } }, { "isoform_ac": "O60291-2", "url": "", "sequence": { "sequence": "MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKKSKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPGRPTSMETAHGLATTSPTWPPLGGPSPDPSAAELTPL", "length": 576, "header": "sp|O60291-2|MGRN1_HUMAN Isoform 2 of E3 ubiquitin-protein ligase MGRN1 OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=2 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4688905, "end_pos": 4624961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000262370.12", "url": "https://www.ensembl.org/id/ENST00000262370.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000262370.6", "url": "https://www.ensembl.org/id/ENSP00000262370.6" } ] } }, { "isoform_ac": "O60291-3", "url": "", "sequence": { "sequence": "MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPGRPTSMETAHGLATTSPTWPPLGGPSPDPSAAELTPL", "length": 554, "header": "sp|O60291-3|MGRN1_HUMAN Isoform 3 of E3 ubiquitin-protein ligase MGRN1 OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=2 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4688905, "end_pos": 4624961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000588994.5", "url": "https://www.ensembl.org/id/ENST00000588994.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000468819.1", "url": "https://www.ensembl.org/id/ENSP00000468819.1" } ] } }, { "isoform_ac": "O60291-4", "url": "", "sequence": { "sequence": "MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDLNFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSLEFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDFSEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGISDGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPLGGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPALGPDSCSVGIDE", "length": 530, "header": "sp|O60291-4|MGRN1_HUMAN Isoform 4 of E3 ubiquitin-protein ligase MGRN1 OS=Homo sapiens OX=9606 GN=MGRN1 PE=1 SV=2 CANONICAL=O60291-1" }, "locus": { "chromosome": "16", "start_pos": 4686296, "end_pos": 4624961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586183.5", "url": "https://www.ensembl.org/id/ENST00000586183.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000465860.1", "url": "https://www.ensembl.org/id/ENSP00000465860.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 411, "end_pos": 411, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "site_lbl": "Tyr411" }, { "start_pos": 454, "end_pos": 454, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O60291", "url": "http://phospho.elm.eu.org/byAccession/O60291.html" }, { "database": "iPTMnet", "id": "O60291", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60291" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Thr454" }, { "start_pos": 459, "end_pos": 459, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O60291", "url": "http://phospho.elm.eu.org/byAccession/O60291.html" }, { "database": "iPTMnet", "id": "O60291", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60291" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ], "site_lbl": "Ser459" }, { "start_pos": 471, "end_pos": 471, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "site_lbl": "Ser471" }, { "start_pos": 524, "end_pos": 524, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "phospho.ELM", "id": "O60291", "url": "http://phospho.elm.eu.org/byAccession/O60291.html" }, { "database": "iPTMnet", "id": "O60291", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60291" } ], "site_lbl": "Ser524" } ], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Two new proteases in the MHC class I processing pathway.", "journal": "Nature immunology", "date": "2000", "authors": "Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11062501", "url": "https://glygen.org/publication/PubMed/11062501" } ] }, { "title": "26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide.", "journal": "The EMBO journal", "date": "2001", "authors": "Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "11350924", "url": "https://glygen.org/publication/PubMed/11350924" } ] }, { "title": "U-box proteins as a new family of ubiquitin ligases.", "journal": "Biochemical and biophysical research communications", "date": "2003", "authors": "Hatakeyama S, Nakayama KI", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "12646216", "url": "https://glygen.org/publication/PubMed/12646216" } ] }, { "title": "Proteasome and peptidase function in MHC-class-I-mediated antigen presentation.", "journal": "Current opinion in immunology", "date": "2004", "authors": "Kloetzel PM, Ossendorp F", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "14734113", "url": "https://glygen.org/publication/PubMed/14734113" } ] }, { "title": "Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII.", "journal": "Nature immunology", "date": "2004", "authors": "Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15224091", "url": "https://glygen.org/publication/PubMed/15224091" } ] }, { "title": "Post-proteasomal antigen processing for major histocompatibility complex class I presentation.", "journal": "Nature immunology", "date": "2004", "authors": "Rock KL, York IA, Goldberg AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15224092", "url": "https://glygen.org/publication/PubMed/15224092" } ] }, { "title": "The proteasome and MHC class I antigen processing.", "journal": "Biochimica et biophysica acta", "date": "2004", "authors": "Kloetzel PM", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "15571818", "url": "https://glygen.org/publication/PubMed/15571818" } ] }, { "title": "Pleiotropic effects of ATP.Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Tokgoz Z, Bohnsack RN, Haas AL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16595681", "url": "https://glygen.org/publication/PubMed/16595681" } ] }, { "title": "Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2006", "authors": "York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16849449", "url": "https://glygen.org/publication/PubMed/16849449" } ] }, { "title": "A novel family of membrane-bound E3 ubiquitin ligases.", "journal": "Journal of biochemistry", "date": "2006", "authors": "Ohmura-Hoshino M, Goto E, Matsuki Y, Aoki M, Mito M, Uematsu M, Hotta H, Ishido S", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "16954532", "url": "https://glygen.org/publication/PubMed/16954532" } ] }, { "title": "Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking.", "journal": "Molecular biology of the cell", "date": "2007", "authors": "Kim BY, Olzmann JA, Barsh GS, Chin LS, Li L", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" }, { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" } ], "reference": [ { "type": "PubMed", "id": "17229889", "url": "https://glygen.org/publication/PubMed/17229889" } ] }, { "title": "Structural insights into E1-catalyzed ubiquitin activation and transfer to conjugating enzymes.", "journal": "Cell", "date": "2008", "authors": "Lee I, Schindelin H", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "18662542", "url": "https://glygen.org/publication/PubMed/18662542" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" }, { "database": "iPTMnet", 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Martin-Gonzalez M, Lazaro P, Benitez J, Ribas G", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" } ], "reference": [ { "type": "PubMed", "id": "19320733", "url": "https://glygen.org/publication/PubMed/19320733" } ] }, { "title": "Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways.", "journal": "Nature reviews. Molecular cell biology", "date": "2009", "authors": "Schulman BA, Harper JW", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19352404", "url": "https://glygen.org/publication/PubMed/19352404" } ] }, { "title": "What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor?", "journal": "Journal of molecular evolution", "date": "2009", "authors": "Michelle C, Vourc'h P, Mignon L, Andres CR", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19452197", "url": "https://glygen.org/publication/PubMed/19452197" } ] }, { "title": "RING domain E3 ubiquitin ligases.", "journal": "Annual review of biochemistry", "date": "2009", "authors": "Deshaies RJ, Joazeiro CA", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19489725", "url": "https://glygen.org/publication/PubMed/19489725" } ] }, { "title": "Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.", "journal": "Biochimica et biophysica acta", "date": "2009", "authors": "Jiao J, Sun K, Walker WP, Bagher P, Cota CD, Gunn TM", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "reference": [ { "type": "PubMed", "id": "19703557", "url": "https://glygen.org/publication/PubMed/19703557" } ] }, { "title": "Mahogunin ring finger-1 (MGRN1) E3 ubiquitin ligase inhibits signaling from melanocortin receptor by competition with Galphas.", "journal": "The Journal of biological chemistry", "date": "2009", "authors": "Perez-Oliva AB, Olivares C, Jimenez-Cervantes C, Garcia-Borron JC", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "reference": [ { "type": "PubMed", "id": "19737927", "url": "https://glygen.org/publication/PubMed/19737927" } ] }, { "title": "Building ubiquitin chains: E2 enzymes at work.", "journal": "Nature reviews. Molecular cell biology", "date": "2009", "authors": "Ye Y, Rape M", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19851334", "url": "https://glygen.org/publication/PubMed/19851334" } ] }, { "title": "Mechanisms of ubiquitin transfer by the anaphase-promoting complex.", "journal": "Journal of biology", "date": "2009", "authors": "Matyskiela ME, Rodrigo-Brenni MC, Morgan DO", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19874575", "url": "https://glygen.org/publication/PubMed/19874575" } ] }, { "title": "The family of ubiquitin-conjugating enzymes (E2s): deciding between life and death of proteins.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2010", "authors": "van Wijk SJ, Timmers HT", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "19940261", "url": "https://glygen.org/publication/PubMed/19940261" } ] }, { "title": "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.", "journal": "Proteomics", "date": "2010", "authors": "Suzuki T, Moriya K, Nagatoshi K, Ota Y, Ezure T, Ando E, Tsunasawa S, Utsumi T", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "reference": [ { "type": "PubMed", "id": "20213681", "url": "https://glygen.org/publication/PubMed/20213681" } ] }, { "title": "Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15.", "journal": "Biochemistry", "date": "1990", "authors": "Pierotti A, Dong KW, Glucksman MJ, Orlowski M, Roberts JL", "evidence": [ { "database": "Reactome", "id": "R-HSA-983168", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983168" } ], "reference": [ { "type": "PubMed", "id": "2261476", "url": "https://glygen.org/publication/PubMed/2261476" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" }, { "database": "iPTMnet", "id": "O60291", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O60291" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Human melanocortin 1 receptor-mediated ubiquitination of nonvisual arrestins. Role of Mahogunin Ring Finger 1 E3 ligase.", "journal": "Biochimica et biophysica acta. Molecular cell research", "date": "2018", "authors": "Abrisqueta M, Olivares C, Herraiz C, Castejon-Grinan M, Sires-Campos J, Garcia-Borron JC, Jimenez-Cervantes C", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" } ], "reference": [ { "type": "PubMed", "id": "28947386", "url": "https://glygen.org/publication/PubMed/28947386" } ] }, { "title": "Mahogunin Ring Finger 1 regulates pigmentation by controlling the pH of melanosomes in melanocytes and melanoma cells.", "journal": "Cellular and molecular life sciences : CMLS", "date": "2021", "authors": "Sires-Campos J, Lambertos A, Delevoye C, Raposo G, Bennett DC, Sviderskaya E, Jimenez-Cervantes C, Olivares C, Garcia-Borron JC", "evidence": [ { "database": "RefSeq", "id": "NP_001135761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135761" } ], "reference": [ { "type": "PubMed", "id": "34921635", "url": "https://glygen.org/publication/PubMed/34921635" } ] }, { 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"https://www.ebi.ac.uk/QuickGO/term/GO:0043951", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "pmid": "" }, { "name": "protein monoubiquitination", "id": "GO:0006513", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006513", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "pmid": "" }, { "name": "negative regulation of smoothened signaling pathway", "id": "GO:0045879", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045879", "evidence": [ { "database": "UniProtKB", "id": "O60291", "url": "https://www.uniprot.org/uniprot/O60291" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "R-HSA-983140", "name": "Transfer of Ub from E2 to substrate and release of E2", "equation": "", "summary": "Interaction of E3 with both substrate and E2-Ub, brings them into proximity so that ubiquitin is transferred from E2 to the substrate. In most cases the transfer of ubiquitin is direct from E2 to substrate, but in a small subset of E3s, it occurs via a covalent E3-Ub thioester intermediate (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983140", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983140" } ] }, { "id": "R-HSA-983147", "name": "Release of E3 from polyubiquitinated substrate", "equation": "", "summary": "K48 polyubiquitinated substrate dissociates from E3 to become a substrate for a multicatalytic complex called the 26S proteasome.", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O95376-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9Y508-1", "Q6ZNA4-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P46934-1", "Q14139-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1" ], "evidence": [ { "id": "R-HSA-983147", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983147" } ] }, { "id": "R-HSA-983156", "name": "Polyubiquitination of substrate", "equation": "", "summary": "Monoubiquitinated substrate acquires additional ubiquitin modifications in the form of multiple single attachments or a ubiquitin chain. Polyubiquitin chains added through K48 residue of ubiquitin typically targets the substrate for degradation (Raymond et al. 2009).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983156", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983156" } ] }, { "id": "R-HSA-983157", "name": "Interaction of E3 with substrate and E2-Ub complex", "equation": "", "summary": "Ubiquitin E3 ligases confer specificity to ubiquitination by recognizing target substrates and mediating transfer of ubiquitin from an E2 ubiquitin-conjugating enzyme to substrate (Raymond et al. 2009). E3 ligases includes a large, diverse set of proteins characterized by several defining motifs which include a HECT (homologous to E6-associated C-terminus), RING (Really Interesting New Gene) and U-box domains. The E3 ligases can be multisubunit complexes rather than a single polypeptide. Presently three different kinds of E3 complexes have been described called SCF, APC, and VHL. E3 ligases binds to both substrate and an E2 thioesterified with ubiquitin (E2-Ub).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9BYM8-1", "Q9H832-1", "Q969T4-1", "Q7Z7E8-1", "Q9UHC7-1", "Q96PU5-1", "Q9Y2X8-1", "Q9Y4L5-1", "Q8TDB6-1", "Q9NQ86-1", "O43255-1", "Q96BH1-1", "P49427-1", "P61081-1", "P62877-1", "Q8WVD3-1", "Q15386-1", "Q5VVX9-1", "Q86XS8-1", "O94822-1", "Q2Q1W2-1", "O60291-1", "Q5U5Q3-1", "Q96AX9-1", "Q96F44-1", "Q9NVW2-1", "O94874-1", "Q7Z3V4-1", "Q8IUQ4-1", "Q13049-1", "Q9UNE7-1", "Q16763-1", "Q86Y13-1", "Q8TBB1-1", "Q8WV44-1", "Q96PM5-1", "Q9C026-1", "O60260-1", "Q9UBS8-1", "Q9Y252-1", "P60604-1", "Q712K3-1", "Q969K3-1", "O15033-1", "O94972-1", "Q86WT6-1", "Q9H4P4-1", "Q13191-1", "Q14669-1", "Q7Z6Z7-1", "O14933-1", "O95376-1", "P68036-1", "Q96LR5-1", "Q7Z419-1", "Q96J02-1", "Q9BV68-1", "Q969Q1-1", "Q9H0M0-1", "Q9HAU4-1", "Q9HCE7-1", "Q5T447-1", "Q15751-1", "Q9UII4-1", "Q05086-1", "O43164-1", "Q86XT4-1", "P78317-1", "P49459-1", "Q7Z6E9-1", "Q5VTB9-1", "Q5XPI4-1", "Q63HN8-3", "Q6ZMZ0-1", "Q9C0C9-1", "P51668-1", "P61077-1", "Q9Y508-1", "P51965-1", "P61088-1", "P62837-1", "Q6ZNA4-1", "P62253-1", "Q7Z6J8-1", "Q8IWV8-1", "Q8ND25-1", "Q9Y385-1", "Q5T4S7-1", "Q8N7E2-1", "Q8NHG8-1", "Q9HCM9-1", "P19474-1", "Q8WY64-1", "Q9Y4B6-1", "Q6Q0C0-1", "Q6UWE0-1", "Q8N6D2-1", "Q8TC41-1", "Q9NV58-1", "P61086-1", "P46934-1", "P41226-1", "P62256-1", "Q14139-1", "Q96B02-1", "Q9C037-1", "Q8IYU2-1", "Q9P2P5-1", "O95714-1", "Q15034-1", "Q8NG27-1", "Q9BWF2-1", "O94941-1", "P63146-1", "Q5GLZ8-1", "Q5U5R9-1", "Q8IVU3-1", "Q9ULT8-1", "Q7Z6J0-1", "Q9H9P5-4", "Q8IWV7-1", "Q8N2K1-1", "Q969M7-1", "O00762-1", "Q8WVN8-1" ], "evidence": [ { "id": "R-HSA-983157", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-983157" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00762", "gene_name": "UBE2C", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O00762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00762" } ] } ] }, { "uniprot_ac": "O14933", "gene_name": "UBE2L6", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14933" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "O14933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14933" } ] } ] }, { "uniprot_ac": "O15033", "gene_name": "AREL1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15033" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O15033", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15033" } ] } ] }, { "uniprot_ac": "O43164", "gene_name": "PJA2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43164" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43164", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43164" } ] } ] }, { "uniprot_ac": "O43255", "gene_name": "SIAH2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43255" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O43255", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43255" } ] } ] }, { "uniprot_ac": "O60260", "gene_name": "PRKN", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] }, { "ec_number": "6.3.2.19", "activity": "", "evidence": [ { "id": "O60260", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60260" } ] } ] }, { "uniprot_ac": "O60291", "gene_name": "MGRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60291" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O60291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60291" } ] } ] }, { "uniprot_ac": "O94822", "gene_name": "LTN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94822" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94822", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94822" } ] } ] }, { "uniprot_ac": "O94874", "gene_name": "UFL1", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "O94874", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94874" } ] } ] }, { "uniprot_ac": "O94941", "gene_name": "UBOX5", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94941" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94941", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94941" } ] } ] }, { "uniprot_ac": "O94972", "gene_name": "TRIM37", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94972" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O94972", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O94972" } ] } ] }, { "uniprot_ac": "O95376", "gene_name": "ARIH2", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95376" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "O95376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95376" } ] } ] }, { "uniprot_ac": "O95714", "gene_name": "HERC2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95714" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "O95714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95714" } ] } ] }, { "uniprot_ac": "P19474", "gene_name": "TRIM21", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19474" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P19474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19474" } ] } ] }, { "uniprot_ac": "P41226", "gene_name": "UBA7", "activity": [ { "ec_number": "6.2.1.-", "activity": "", "evidence": [ { "id": "P41226", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41226" } ] } ] }, { "uniprot_ac": "P46934", "gene_name": "NEDD4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46934" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "P46934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46934" } ] } ] }, { "uniprot_ac": "P49427", "gene_name": "CDC34", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49427", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49427" } ] } ] }, { "uniprot_ac": "P49459", "gene_name": "UBE2A", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49459" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P49459", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49459" } ] } ] }, { "uniprot_ac": "P51668", "gene_name": "UBE2D1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51668", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51668" } ] } ] }, { "uniprot_ac": "P51965", "gene_name": "UBE2E1", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P51965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51965" } ] } ] }, { "uniprot_ac": "P60604", "gene_name": "UBE2G2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60604" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P60604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60604" } ] } ] }, { "uniprot_ac": "P61077", "gene_name": "UBE2D3", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61077", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61077" } ] } ] }, { "uniprot_ac": "P61081", "gene_name": "UBE2M", "activity": [ { "ec_number": "2.3.2.34", "activity": "[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61081" } ] }, { "ec_number": "2.3.2.34", "activity": "", "evidence": [ { "id": "P61081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61081" } ] } ] }, { "uniprot_ac": "P61086", "gene_name": "UBE2K", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61086" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61086" } ] } ] }, { "uniprot_ac": "P61088", "gene_name": "UBE2N", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61088" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P61088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P61088" } ] } ] }, { "uniprot_ac": "P62253", "gene_name": "UBE2G1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62253" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62253", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62253" } ] } ] }, { "uniprot_ac": "P62256", "gene_name": "UBE2H", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] }, { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62256" } ] } ] }, { "uniprot_ac": "P62837", "gene_name": "UBE2D2", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P62837", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62837" } ] } ] }, { "uniprot_ac": "P62877", "gene_name": "RBX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P62877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62877" } ] } ] }, { "uniprot_ac": "P63146", "gene_name": "UBE2B", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63146" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P63146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63146" } ] } ] }, { "uniprot_ac": "P68036", "gene_name": "UBE2L3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68036" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "P68036", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68036" } ] } ] }, { "uniprot_ac": "P78317", "gene_name": "RNF4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78317" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "P78317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P78317" } ] } ] }, { "uniprot_ac": "Q05086", "gene_name": "UBE3A", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05086" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q05086", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05086" } ] } ] }, { "uniprot_ac": "Q13049", "gene_name": "TRIM32", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13049" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13049", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13049" } ] } ] }, { "uniprot_ac": "Q13191", "gene_name": "CBLB", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13191" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q13191", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13191" } ] } ] }, { "uniprot_ac": "Q14139", "gene_name": "UBE4A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14139" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q14139", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14139" } ] } ] }, { "uniprot_ac": "Q14669", "gene_name": "TRIP12", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14669" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q14669", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14669" } ] } ] }, { "uniprot_ac": "Q15034", "gene_name": "HERC3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15034" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15034", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15034" } ] } ] }, { "uniprot_ac": "Q15386", "gene_name": "UBE3C", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15386" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15386", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15386" } ] } ] }, { "uniprot_ac": "Q15751", "gene_name": "HERC1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15751" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q15751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15751" } ] } ] }, { "uniprot_ac": "Q16763", "gene_name": "UBE2S", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q16763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16763" } ] } ] }, { "uniprot_ac": "Q2Q1W2", "gene_name": "TRIM71", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2Q1W2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q2Q1W2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q2Q1W2" } ] } ] }, { "uniprot_ac": "Q5GLZ8", "gene_name": "HERC4", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GLZ8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5GLZ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5GLZ8" } ] } ] }, { "uniprot_ac": "Q5T447", "gene_name": "HECTD3", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T447" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5T447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T447" } ] } ] }, { "uniprot_ac": "Q5T4S7", "gene_name": "UBR4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T4S7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5T4S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5T4S7" } ] } ] }, { "uniprot_ac": "Q5U5Q3", "gene_name": "MEX3C", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5Q3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5U5Q3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5Q3" } ] } ] }, { "uniprot_ac": "Q5U5R9", "gene_name": "HECTD2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5R9" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q5U5R9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U5R9" } ] } ] }, { "uniprot_ac": "Q5VTB9", "gene_name": "RNF220", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VTB9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5VTB9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VTB9" } ] } ] }, { "uniprot_ac": "Q5VVX9", "gene_name": "UBE2U", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VVX9" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q5VVX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5VVX9" } ] } ] }, { "uniprot_ac": "Q5XPI4", "gene_name": "RNF123", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q5XPI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XPI4" } ] } ] }, { "uniprot_ac": "Q63HN8", "gene_name": "RNF213", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "3.6.4.-", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q63HN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63HN8" } ] } ] }, { "uniprot_ac": "Q6Q0C0", "gene_name": "TRAF7", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6Q0C0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6Q0C0" } ] } ] }, { "uniprot_ac": "Q6UWE0", "gene_name": "LRSAM1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWE0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6UWE0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6UWE0" } ] } ] }, { "uniprot_ac": "Q6ZMZ0", "gene_name": "RNF19B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMZ0" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q6ZMZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZMZ0" } ] } ] }, { "uniprot_ac": "Q6ZNA4", "gene_name": "RNF111", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZNA4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q6ZNA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6ZNA4" } ] } ] }, { "uniprot_ac": "Q712K3", "gene_name": "UBE2R2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q712K3" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q712K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q712K3" } ] } ] }, { "uniprot_ac": "Q7Z3V4", "gene_name": "UBE3B", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z3V4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z3V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z3V4" } ] } ] }, { "uniprot_ac": "Q7Z419", "gene_name": "RNF144B", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z419" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q7Z419", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z419" } ] } ] }, { "uniprot_ac": "Q7Z6E9", "gene_name": "RBBP6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6E9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6E9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6E9" } ] } ] }, { "uniprot_ac": "Q7Z6J0", "gene_name": "SH3RF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J0" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q7Z6J0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J0" } ] } ] }, { "uniprot_ac": "Q7Z6J8", "gene_name": "UBE3D", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6J8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6J8" } ] } ] }, { "uniprot_ac": "Q7Z6Z7", "gene_name": "HUWE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q7Z6Z7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z6Z7" } ] } ] }, { "uniprot_ac": "Q7Z7E8", "gene_name": "UBE2Q1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z7E8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q7Z7E8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7Z7E8" } ] } ] }, { "uniprot_ac": "Q86WT6", "gene_name": "TRIM69", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WT6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86WT6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86WT6" } ] } ] }, { "uniprot_ac": "Q86XS8", "gene_name": "RNF130", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XS8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XS8" } ] } ] }, { "uniprot_ac": "Q86XT4", "gene_name": "TRIM50", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XT4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86XT4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86XT4" } ] } ] }, { "uniprot_ac": "Q86Y13", "gene_name": "DZIP3", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y13" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q86Y13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86Y13" } ] } ] }, { "uniprot_ac": "Q8IUQ4", "gene_name": "SIAH1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IUQ4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IUQ4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IUQ4" } ] } ] }, { "uniprot_ac": "Q8IVU3", "gene_name": "HERC6", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IVU3" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IVU3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IVU3" } ] } ] }, { "uniprot_ac": "Q8IWV7", "gene_name": "UBR1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV7" } ] } ] }, { "uniprot_ac": "Q8IWV8", "gene_name": "UBR2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8IWV8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IWV8" } ] } ] }, { "uniprot_ac": "Q8IYU2", "gene_name": "HACE1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IYU2" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q8IYU2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IYU2" } ] } ] }, { "uniprot_ac": "Q8N2K1", "gene_name": "UBE2J2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K1" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8N2K1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N2K1" } ] } ] }, { "uniprot_ac": "Q8N6D2", "gene_name": "RNF182", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N6D2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N6D2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N6D2" } ] } ] }, { "uniprot_ac": "Q8N7E2", "gene_name": "CBLL2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N7E2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8N7E2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N7E2" } ] } ] }, { "uniprot_ac": "Q8ND25", "gene_name": "ZNRF1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ND25" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8ND25", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ND25" } ] } ] }, { "uniprot_ac": "Q8NG27", "gene_name": "PJA1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG27" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NG27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NG27" } ] } ] }, { "uniprot_ac": "Q8NHG8", "gene_name": "ZNRF2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NHG8" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8NHG8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NHG8" } ] } ] }, { "uniprot_ac": "Q8TBB1", "gene_name": "LNX1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TBB1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TBB1" } ] } ] }, { "uniprot_ac": "Q8TC41", "gene_name": "RNF217", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC41" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q8TC41", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TC41" } ] } ] }, { "uniprot_ac": "Q8TDB6", "gene_name": "DTX3L", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDB6" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8TDB6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TDB6" } ] } ] }, { "uniprot_ac": "Q8WV44", "gene_name": "TRIM41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WV44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WV44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WV44" } ] } ] }, { "uniprot_ac": "Q8WVD3", "gene_name": "RNF138", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVD3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WVD3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVD3" } ] } ] }, { "uniprot_ac": "Q8WVN8", "gene_name": "UBE2Q2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVN8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q8WVN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVN8" } ] } ] }, { "uniprot_ac": "Q8WY64", "gene_name": "MYLIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY64" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q8WY64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY64" } ] } ] }, { "uniprot_ac": "Q969K3", "gene_name": "RNF34", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969K3" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969K3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969K3" } ] } ] }, { "uniprot_ac": "Q969M7", "gene_name": "UBE2F", "activity": [ { "ec_number": "2.3.2.32", "activity": "S-[NEDD8-protein]-yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-[NEDD8-protein]-yl-[cullin]-L-lysine.", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969M7" } ] }, { "ec_number": "2.3.2.32", "activity": "", "evidence": [ { "id": "Q969M7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969M7" } ] } ] }, { "uniprot_ac": "Q969Q1", "gene_name": "TRIM63", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969Q1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q969Q1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969Q1" } ] } ] }, { "uniprot_ac": "Q969T4", "gene_name": "UBE2E3", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969T4" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q969T4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q969T4" } ] } ] }, { "uniprot_ac": "Q96AX9", "gene_name": "MIB2", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AX9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96AX9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96AX9" } ] } ] }, { "uniprot_ac": "Q96B02", "gene_name": "UBE2W", "activity": [ { "ec_number": "2.3.2.25", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] }, { "ec_number": "2.3.2.25", "activity": "", "evidence": [ { "id": "Q96B02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96B02" } ] } ] }, { "uniprot_ac": "Q96BH1", "gene_name": "RNF25", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BH1" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96BH1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96BH1" } ] } ] }, { "uniprot_ac": "Q96F44", "gene_name": "TRIM11", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96F44" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96F44", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96F44" } ] } ] }, { "uniprot_ac": "Q96J02", "gene_name": "ITCH", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J02" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96J02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96J02" } ] } ] }, { "uniprot_ac": "Q96LR5", "gene_name": "UBE2E2", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LR5" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q96LR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96LR5" } ] } ] }, { "uniprot_ac": "Q96PM5", "gene_name": "RCHY1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PM5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q96PM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PM5" } ] } ] }, { "uniprot_ac": "Q96PU5", "gene_name": "NEDD4L", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] }, { "ec_number": "2.3.2.36", "activity": "", "evidence": [ { "id": "Q96PU5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96PU5" } ] } ] }, { "uniprot_ac": "Q9BV68", "gene_name": "RNF126", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV68" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BV68", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV68" } ] } ] }, { "uniprot_ac": "Q9BWF2", "gene_name": "TRAIP", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWF2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9BWF2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BWF2" } ] } ] }, { "uniprot_ac": "Q9BYM8", "gene_name": "RBCK1", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYM8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9BYM8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BYM8" } ] } ] }, { "uniprot_ac": "Q9C026", "gene_name": "TRIM9", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C026" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C026", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C026" } ] } ] }, { "uniprot_ac": "Q9C037", "gene_name": "TRIM4", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C037" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9C037", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C037" } ] } ] }, { "uniprot_ac": "Q9C0C9", "gene_name": "UBE2O", "activity": [ { "ec_number": "2.3.2.24", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C0C9" } ] }, { "ec_number": "2.3.2.24", "activity": "", "evidence": [ { "id": "Q9C0C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9C0C9" } ] } ] }, { "uniprot_ac": "Q9H0M0", "gene_name": "WWP1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0M0" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9H0M0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0M0" } ] } ] }, { "uniprot_ac": "Q9H4P4", "gene_name": "RNF41", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4P4" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9H4P4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H4P4" } ] } ] }, { "uniprot_ac": "Q9H832", "gene_name": "UBE2Z", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H832" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9H832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H832" } ] } ] }, { "uniprot_ac": "Q9H9P5", "gene_name": "UNKL", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9H9P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H9P5" } ] } ] }, { "uniprot_ac": "Q9HAU4", "gene_name": "SMURF2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAU4" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HAU4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAU4" } ] } ] }, { "uniprot_ac": "Q9HCE7", "gene_name": "SMURF1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCE7" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9HCE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCE7" } ] } ] }, { "uniprot_ac": "Q9HCM9", "gene_name": "TRIM39", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCM9" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9HCM9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HCM9" } ] } ] }, { "uniprot_ac": "Q9NQ86", "gene_name": "TRIM36", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQ86" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NQ86", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NQ86" } ] } ] }, { "uniprot_ac": "Q9NV58", "gene_name": "RNF19A", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV58" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9NV58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NV58" } ] } ] }, { "uniprot_ac": "Q9NVW2", "gene_name": "RLIM", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NVW2" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9NVW2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9NVW2" } ] } ] }, { "uniprot_ac": "Q9P2P5", "gene_name": "HECW2", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P2P5" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9P2P5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9P2P5" } ] } ] }, { "uniprot_ac": "Q9UBS8", "gene_name": "RNF14", "activity": [ { "ec_number": "2.3.2.31", "activity": "[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBS8" } ] }, { "ec_number": "2.3.2.31", "activity": "", "evidence": [ { "id": "Q9UBS8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UBS8" } ] } ] }, { "uniprot_ac": "Q9UHC7", "gene_name": "MKRN1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHC7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UHC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UHC7" } ] } ] }, { "uniprot_ac": "Q9UII4", "gene_name": "HERC5", "activity": [ { "ec_number": "2.3.2.-", "activity": "", "evidence": [ { "id": "Q9UII4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UII4" } ] } ] }, { "uniprot_ac": "Q9ULT8", "gene_name": "HECTD1", "activity": [ { "ec_number": "2.3.2.26", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULT8" } ] }, { "ec_number": "2.3.2.26", "activity": "", "evidence": [ { "id": "Q9ULT8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ULT8" } ] } ] }, { "uniprot_ac": "Q9UNE7", "gene_name": "STUB1", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNE7" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9UNE7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9UNE7" } ] } ] }, { "uniprot_ac": "Q9Y252", "gene_name": "RNF6", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y252" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y252", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y252" } ] } ] }, { "uniprot_ac": "Q9Y2X8", "gene_name": "UBE2D4", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2X8" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y2X8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y2X8" } ] } ] }, { "uniprot_ac": "Q9Y385", "gene_name": "UBE2J1", "activity": [ { "ec_number": "2.3.2.23", "activity": "S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y385" } ] }, { "ec_number": "2.3.2.23", "activity": "", "evidence": [ { "id": "Q9Y385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y385" } ] } ] }, { "uniprot_ac": "Q9Y4B6", "gene_name": "DCAF1", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y4B6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4B6" } ] } ] }, { "uniprot_ac": "Q9Y4L5", "gene_name": "RNF115", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4L5" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y4L5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y4L5" } ] } ] }, { "uniprot_ac": "Q9Y508", "gene_name": "RNF114", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "Q9Y508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y508" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "Q9Y508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y508" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [ 411, 454, 459, 471, 524 ], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 31 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }