{ "uniprot_canonical_ac": "O60235-1", "uniprot_ac": "O60235", "uniprot_id": "TM11D_HUMAN", "mass": { "chemical_mass": 46263.0, "monoisotopic_mass": 46263.0 }, "refseq": { "ac": "NP_004253", "name": "transmembrane protease serine 11D", "summary": "This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" }, "gene_names": [ { "name": "TMPRSS11D", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O60235", "id": "O60235" }, { "name": "ASP; HAT", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253", "id": "NP_004253" }, { "name": "HAT", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O60235", "id": "O60235" }, { "name": "TMPRSS11D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253", "id": "NP_004253" } ], "protein_names": [ { "name": "Transmembrane protease serine 11D", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O60235" }, { "name": "3.4.21.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60235" }, { "name": "Airway trypsin-like protease", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O60235" }, { "name": "airway trypsin-like protease; transmembrane protease, serine 11D; adrenal secretory serine protease", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253", "id": "NP_004253" }, { "name": "transmembrane protease serine 11D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253", "id": "NP_004253" } ], "function": [ { "annotation": "HAT might promote PAR-2-mediated IL-8 production to accumulate inflammatory cells in the epidermal layer of psoriasis.", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" }, { "database": "PubMed", "id": "15102084", "url": "https://glygen.org/publication/PubMed/15102084" } ] }, { "annotation": "HAT regulates cellular functions of human bronchial epithelial cells via activation of protease-activated receptor-2.", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" }, { "database": "PubMed", "id": "12630574", "url": "https://glygen.org/publication/PubMed/12630574" } ] }, { "annotation": "HalphaT is associated with increased risk for severe Hymenoptera venom-triggered anaphylaxis.", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" }, { "database": "PubMed", "id": "36529562", "url": "https://glygen.org/publication/PubMed/36529562" } ] }, { "annotation": "May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235#function" }, { "database": "PubMed", "id": "23536651", "url": "https://glygen.org/publication/PubMed/23536651" }, { "database": "PubMed", "id": "24227843", "url": "https://glygen.org/publication/PubMed/24227843" } ] }, { "annotation": "TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" }, { "database": "PubMed", "id": "33671076", "url": "https://glygen.org/publication/PubMed/33671076" } ] }, { "annotation": "TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" }, { "database": "PubMed", "id": "37666068", "url": "https://glygen.org/publication/PubMed/37666068" } ] }, { "annotation": "This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021].", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs755058043", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755058043" }, { "id": "rs755058043", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755058043" }, { "id": "rs755058043", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs755058043#frequency_tab" }, { "id": "rs755058043", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755058043" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 127, "end_pos": 127, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNN->NNS).", "chr_id": "4", "chr_pos": "67838267", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N127", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1374410453", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1374410453" }, { "id": "rs1374410453", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1374410453" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 129, "end_pos": 129, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NGA->NGT).", "chr_id": "4", "chr_pos": "67838262", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A129", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs776326215", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776326215" }, { "id": "rs776326215", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs776326215" }, { "id": "rs776326215", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs776326215" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 144, "end_pos": 144, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NNS->SNS).", "chr_id": "4", "chr_pos": "67838216", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N144", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1414208885", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1414208885" }, { "id": "rs1414208885", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1414208885#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 153, "end_pos": 153, "sequence_org": "P", "sequence_mut": "L", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPS->NLS).", "chr_id": "4", "chr_pos": "67838189", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P153", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1387144275", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1387144275" }, { "id": "rs1387144275", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1387144275" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 209, "end_pos": 209, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNA->NNT).", "chr_id": "4", "chr_pos": "67833271", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A209", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs757851651", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757851651" }, { "id": "rs757851651", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs757851651" }, { "id": "rs757851651", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs757851651" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 259, "end_pos": 259, "sequence_org": "L", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIL->NIS).", "chr_id": "4", "chr_pos": "67827437", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "L259", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O60235", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O60235" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 265, "end_pos": 265, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "K", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NYK->NYT).", "chr_id": "4", "chr_pos": "67827419", "ref_nt": "T", "alt_nt": "G", "minor_allelic_frequency": "", "site_lbl": "K265", "disease": [ { "disease_id": "DOID:9256", "recommended_name": { "id": "DOID:9256", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:9256", "name": "colorectal cancer", "description": "A large intestine cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs150964886", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150964886" }, { "id": "rs150964886", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs150964886" }, { "id": "rs150964886", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs150964886" }, { "id": "rs150964886", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs150964886#frequency_tab" }, { "id": "rs150964886", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs150964886" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 340, "end_pos": 340, "sequence_org": "P", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NAP->NAS).", "chr_id": "4", "chr_pos": 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"id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O60235", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60235" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O60235" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000283916.11", "url": "https://www.ensembl.org/id/ENST00000283916.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000283916.6", "url": "https://www.ensembl.org/id/ENSP00000283916.6" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 144, "start_aa": "Asn", "end_pos": 144, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn144", "evidence": [ { "id": "O60235", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60235#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 283, "start_aa": "Thr", "end_pos": 283, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr283", "evidence": [ { "id": "O60235", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60235" }, { "id": "30620550", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30620550" }, { "id": "O60235", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O60235" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Effect of human airway trypsin-like protease on intracellular free Ca2+ concentration in human bronchial epithelial cells.", "journal": "The journal of medical investigation : JMI", "date": "2003", "authors": "Miki M, Nakamura Y, Takahashi A, Nakaya Y, Eguchi H, Masegi T, Yoneda K, Yasuoka S, Sone S", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" } ], "reference": [ { "type": "PubMed", "id": "12630574", "url": "https://glygen.org/publication/PubMed/12630574" } ] }, { "title": "Human airway trypsin-like protease induces PAR-2-mediated IL-8 release in psoriasis vulgaris.", "journal": "The Journal of investigative dermatology", "date": "2004", "authors": "Iwakiri K, Ghazizadeh M, Jin E, Fujiwara M, Takemura T, Takezaki S, Kawana S, Yasuoka S, Kawanami O", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" } ], "reference": [ { "type": "PubMed", "id": "15102084", "url": "https://glygen.org/publication/PubMed/15102084" } ] }, { "title": "TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.", "journal": "Journal of virology", "date": "2013-06", "authors": "Bertram Stephanie, Dijkman Ronald, Habjan Matthias, Heurich Adeline, Gierer Stefanie, Glowacka Ilona, Welsch Kathrin, Winkler Michael, Schneider Heike, Hofmann-Winkler Heike, Thiel Volker, P\u00f6hlmann Stefan", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "reference": [ { "type": "PubMed", "id": "23536651", "url": "https://glygen.org/publication/PubMed/23536651" } ] }, { "title": "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.", "journal": "Journal of virology", "date": "2014", "authors": "Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pohlmann S", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "reference": [ { "type": "PubMed", "id": "24227843", "url": "https://glygen.org/publication/PubMed/24227843" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O60235", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O60235" }, { "database": "O-GlcNAc Atlas", "id": "O60235", "url": "https://oglcnac.org/atlas/detail/O60235" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein.", "journal": "Viruses", "date": "2021", "authors": "Kishimoto M, Uemura K, Sanaki T, Sato A, Hall WW, Kariwa H, Orba Y, Sawa H, Sasaki M", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" } ], "reference": [ { "type": "PubMed", "id": "33671076", "url": "https://glygen.org/publication/PubMed/33671076" } ] }, { "title": "H\u03b1T is associated with increased risk for severe Hymenoptera venom-triggered anaphylaxis.", "journal": "The Journal of allergy and clinical immunology", "date": "2022-12-16", "authors": "\u0160elb Julij, Rijavec Matija, Kopa\u010d Peter, Lyons Jonathan J, Koro\u0161ec Peter", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" } ], "reference": [ { "type": "PubMed", "id": "36529562", "url": "https://glygen.org/publication/PubMed/36529562" } ] }, { "title": "TMPRSS11D/ALR-mediated ER stress regulates the function of myeloid-derived suppressor cells in the cervical cancer microenvironment.", "journal": "International immunopharmacology", "date": "2023-11", "authors": "Feng Sifang, Zhao Juan, Yang Ting, Li Long", "evidence": [ { "database": "RefSeq", "id": "NP_004253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004253" } ], "reference": [ { "type": "PubMed", "id": "37666068", "url": "https://glygen.org/publication/PubMed/37666068" } ] }, { "title": "Purification, characterization, and localization of a novel trypsin-like protease found in the human airway.", "journal": "Am. J. Respir. Cell Mol. Biol.", "date": "1997", "authors": "Yasuoka S, Ohnishi T, Kawano S, Tsuchihashi S, Ogawara M, Masuda K, Yamaoka K, Takahashi M, Sano T", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "reference": [ { "type": "PubMed", "id": "9070615", "url": "https://glygen.org/publication/PubMed/9070615" } ] }, { "title": "Cloning and characterization of the cDNA for human airway trypsin-like protease.", "journal": "J. Biol. Chem.", "date": "1998", "authors": "Yamaoka K, Masuda K, Ogawa H, Takagi K, Umemoto N, Yasuoka S", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "reference": [ { "type": "PubMed", "id": "9565616", "url": "https://glygen.org/publication/PubMed/9565616" } ] } ], "pathway": [ { "id": "hsa:9407", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9407", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q8VHJ4-1", "protein_name": "Transmembrane protease serine 11D", "gene_name": "Tmprss11d", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MYRPRSMVSPSRFFNPFMVALIVIITVGLLAMTAGLLIHFLAFDKRAYFYHSNFHILNVDYTEALNSPATHEYRTLSERIESMITDAFRESNLRSEFIRTHVVKLRKEGSGVVADVVMKFRSSKRNNKKAIKTRIQSVLQRLSSSGNLEIAPSNGITSLTDQDTENVLTQECGARPDLITLSEERIIGGTQAETGDWPWQVSLQLNNVHHCGGTLISNLWVLTAAHCFRSYSNPQQWTATFGVSTISPRLRVRVRAILAHAEYNSITRDNDIAVVQLDRPVTFTRNIHRVCLPAATQNIMPDSVAYVTGWGSLTYGGNTVTNLQQGEVRIVSSEVCNEPAGYGGSVLPGMLCAGVRSGAVDACQGDSGGPLVQEDTRRLWFVVGIVSWGYQCGLPNKPGVYTRVTAYRNWIRQQTGI", "length": 417 }, "evidence": [ { "id": "45936622", "url": "http://www.informatics.jax.org/homology/45936622", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8VHK8-1", "protein_name": "Transmembrane protease serine 11D", "gene_name": "Tmprss11d", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MYRPRPMLSPSRFFTPFAVAFVVIITVGLLAMMAGLLIHFLAFDKKAYFYHSSFQILNVEYTEALNSPATHEYRTLSERIEAMITDEFRGSSLKSEFIRTHVVKLRKEGTGVVADVVMKFRSSKRNNRKVMKTRIQSVLRRLSSSGNLEIAPSNEITSLTDQDTENVLTQECGARPDLITLSEERIIGGMQAEPGDWPWQVSLQLNNVHHCGGALISNMWVLTAAHCFKSYPNPQYWTATFGVSTMSPRLRVRVRAILAHDGYSSVTRDNDIAVVQLDRSVAFSRNIHRVCLPAATQNIIPGSVAYVTGWGSLTYGGNAVTNLRQGEVRIISSEECNTPAGYSGSVLPGMLCAGMRSGAVDACQGDSGGPLVQEDSRRLWFVVGIVSWGYQCGLPNKPGVYTRVTAYRNWIRQQTGI", "length": 417 }, "evidence": [ { "id": "45936622", "url": "http://www.informatics.jax.org/homology/45936622", "database": "MGI" }, { "id": "O60235", "url": "https://omabrowser.org/oma/group/O60235/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 2, "go_terms": [ { "name": "serine-type endopeptidase activity", "id": "GO:0004252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004252", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "pmid": "" }, { "name": "peptidase activity", "id": "GO:0008233", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008233", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "extracellular region", "id": "GO:0005576", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "proteolysis", "id": "GO:0006508", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006508", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "pmid": "" }, { "name": "respiratory gaseous exchange by respiratory system", "id": "GO:0007585", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007585", "evidence": [ { "database": "UniProtKB", "id": "O60235", "url": "https://www.uniprot.org/uniprot/O60235" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 144, "end_pos": 146, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 144 ], "o_linked_sites": [ 283 ], "snv_sites": [ 61, 127, 129, 144, 153, 209, 259, 265, 340, 347 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 144, "end_pos": 146 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 10 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 10 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 10 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }