{ "uniprot_canonical_ac": "O43827-1", "uniprot_ac": "O43827", "uniprot_id": "ANGL7_HUMAN", "mass": { "chemical_mass": 40018.0, "monoisotopic_mass": 40018.0 }, "refseq": { "ac": "NP_066969", "name": "angiopoietin-related protein 7 precursor", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" }, "gene_names": [ { "name": "ANGPTL7", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43827", "id": "O43827" }, { "name": "ANGPTL7", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969", "id": "NP_066969" }, { "name": "AngX; CDT6; dJ647M16.1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969", "id": "NP_066969" }, { "name": "CDT6", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43827", "id": "O43827" }, { "name": "PRO356", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43827", "id": "O43827" } ], "protein_names": [ { "name": "Angiopoietin-related protein 7", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43827" }, { "name": "Angiopoietin-like factor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43827" }, { "name": "Angiopoietin-like protein 7", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43827" }, { "name": "Cornea-derived transcript 6 protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43827" }, { "name": "angiopoietin-related protein 7 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969", "id": "NP_066969" }, { "name": "angiopoietin-related protein 7; angiopoietin-like factor (CDT6); angiopoietin-like protein 7; cornea-derived transcript 6 protein", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969", "id": "NP_066969" } ], "function": [ { "annotation": "ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" }, { "database": "PubMed", "id": "36192519", "url": "https://glygen.org/publication/PubMed/36192519" } ] }, { "annotation": "Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036).", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827#function" }, { "database": "PubMed", "id": "25622036", "url": "https://glygen.org/publication/PubMed/25622036" }, { "database": "PubMed", "id": "21199193", "url": "https://glygen.org/publication/PubMed/21199193" } ] }, { "annotation": "Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" }, { "database": "PubMed", "id": "36017324", "url": "https://glygen.org/publication/PubMed/36017324" } ] }, { "annotation": "Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7.", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" }, { "database": "PubMed", "id": "36853945", "url": "https://glygen.org/publication/PubMed/36853945" } ] }, { "annotation": "Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression.", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" }, { "database": "PubMed", "id": "37220876", "url": "https://glygen.org/publication/PubMed/37220876" } ] }, { "annotation": "The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" }, { "database": "PubMed", "id": "37319434", "url": "https://glygen.org/publication/PubMed/37319434" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs768514152", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768514152" }, { "id": "rs768514152", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs768514152" }, { "id": "rs768514152", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs768514152#frequency_tab" }, { "id": "rs768514152", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs768514152" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 109, "end_pos": 109, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 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n-glyco-sequon-gain (DCS->NCS).", "chr_id": "1", "chr_pos": "11192281", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D130", "keywords": [ "ebi", "somatic" ] }, { "evidence": [ { "id": "rs772214701", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772214701" }, { "id": "rs772214701", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772214701" }, { "id": "rs772214701", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs772214701#frequency_tab" }, { "id": "rs772214701", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs772214701" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 231, "end_pos": 231, "sequence_org": "R", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLR->NLS).", "chr_id": "1", "chr_pos": "11194479", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R231", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs745621835", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745621835" }, { "id": "rs745621835", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745621835" }, { "id": "rs745621835", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs745621835#frequency_tab" }, { "id": "rs745621835", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs745621835" }, { "id": "22895193", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22895193" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 262, "end_pos": 262, "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDA->NDT).", "chr_id": "1", "chr_pos": "11194572", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A262", "keywords": [ 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"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLS->NLN).", "chr_id": "1", "chr_pos": "11189758", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S60", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "56.32", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171819", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171819" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "42.46", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000171819", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171819" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": 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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", 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}, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL 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"name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O43827", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43827" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", 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"DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O43827", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43827" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "common_name": "Human" } ], "gene": [ { "name": "ANGPTL7", "url": "https://www.uniprot.org/uniprot/O43827", "locus": { "chromosome": "1", "start_pos": 11195981, "end_pos": 11189355, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000171819", "url": "https://www.ensembl.org/id/ENSG00000171819" } ] } } ], "crossref": [ { "id": "ENSG00000171819", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171819", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "cd00087", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00087", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "ANGPTL7", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=ANGPTL7", "database": 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"https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10218", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "618517", "url": "http://www.omim.org/entry/618517", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O43827", "url": "https://www.nextprot.org/entry/NX_O43827", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "WHGANYS", "url": "https://omabrowser.org/oma/group/WHGANYS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3134470at2759", "url": "http://www.orthodb.org/?query=3134470at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR19143", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19143", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19143:SF40", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19143:SF40", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00147", "url": "http://pfam.xfam.org/family/PF00147", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O43827", "url": "https://pharos.nih.gov/targets/O43827", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O43827", "url": "http://purl.obolibrary.org/obo/PR_O43827", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43827-1", "url": "https://www.uniprot.org/uniprot/O43827-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKRVEMKIRPEDFKP", "length": 346, "header": "sp|O43827-1|ANGL7_HUMAN Isoform 1 of Angiopoietin-related protein 7 OS=Homo sapiens OX=9606 GN=ANGPTL7 PE=1 SV=1 CANONICAL=O43827-1" }, "isoforms": [ { "isoform_ac": "O43827-1", "url": "", "sequence": { "sequence": "MLKKPLSAVTWLCIFIVAFVSHPAWLQKLSKHKTPAQPQLKAANCCEEVKELKAQVANLSSLLSELNKKQERDWVSVVMQVMELESNSKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETSGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRQPTRLRVEMEDWEGNLRYAEYSHFVLGNELNSYRLFLGNYTGNVGNDALQYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSTYSLKRVEMKIRPEDFKP", "length": 346, "header": "sp|O43827-1|ANGL7_HUMAN Isoform 1 of Angiopoietin-related protein 7 OS=Homo sapiens OX=9606 GN=ANGPTL7 PE=1 SV=1 CANONICAL=O43827-1" }, "locus": { "chromosome": "1", "start_pos": 11195020, "end_pos": 11189580, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000376819.4", "url": "https://www.ensembl.org/id/ENST00000376819.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000366015.3", "url": "https://www.ensembl.org/id/ENSP00000366015.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 253, "start_aa": "Asn", "end_pos": 253, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn253", "evidence": [ { "id": "O43827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43827#ptm_processing" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 267, "start_aa": "Asn", "end_pos": 267, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn267", "evidence": [ { "id": "O43827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43827#ptm_processing" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 44, "start_aa": "Asn", "end_pos": 44, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn44", "evidence": [ { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 58, "start_aa": "Asn", "end_pos": 58, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn58", "evidence": [ { "id": "O43827", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43827#ptm_processing" }, { "id": "23090970", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23090970" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported" ], "publication": [ { "title": "The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3.", "journal": "Genes Immun.", "date": "2001", "authors": "Stover C, Endo Y, Takahashi M, Lynch NJ, Constantinescu C, Vorup-Jensen T, Thiel S, Friedl H, Hankeln T, Hall R, Gregory S, Fujita T, Schwaeble W", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "11426320", "url": "https://glygen.org/publication/PubMed/11426320" } ] }, { "title": "The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea.", "journal": "J. Biol. Chem.", "date": "2002", "authors": "Peek R, Kammerer RA, Frank S, Otte-Holler I, Westphal JR", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "11682471", "url": "https://glygen.org/publication/PubMed/11682471" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "Signal peptide prediction based on analysis of experimentally verified cleavage sites.", "journal": "Protein Sci.", "date": "2004", "authors": "Zhang Z, Henzel WJ", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "15340161", "url": "https://glygen.org/publication/PubMed/15340161" } ] }, { "title": "Gene expression profile of human trabecular meshwork cells in response to long-term dexamethasone exposure.", "journal": "Mol. Vis.", "date": "2006", "authors": "Rozsa Frank W, Reed David M, Scott Kathleen M, Pawar Hemant, Moroi Sayoko E, Kijek Theresa Guckian, Krafchak Charles M, Othman Mohammad I, Vollrath Douglas, Elner Victor M, Richards Julia E", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "16541013", "url": "https://glygen.org/publication/PubMed/16541013" } ] }, { "title": "Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2011-02", "authors": "Comes N\u00faria, Buie Lakisha K, Borr\u00e1s Teresa", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "21199193", "url": "https://glygen.org/publication/PubMed/21199193" } ] }, { "title": "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.", "journal": "Invest. Ophthalmol. Vis. Sci.", "date": "2011", "authors": "Oshikawa Mio, Tsutsui Chihiro, Ikegami Tomoko, Fuchida Yuki, Matsubara Maki, Toyama Shigeru, Usami Ron, Ohtoko Kuniyo, Kato Seishi", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "21697133", "url": "https://glygen.org/publication/PubMed/21697133" } ] }, { "title": "Recurrent R-spondin fusions in colon cancer.", "journal": "Nature", "date": "2012", "authors": "Seshagiri S, Stawiski EW, Durinck S, Modrusan Z, Storm EE, Conboy CB, Chaudhuri S, Guan Y, Janakiraman V, Jaiswal BS, Guillory J, Ha C, Dijkgraaf GJ, Stinson J, Gnad F, Huntley MA, Degenhardt JD, Haverty PM, Bourgon R, Wang W, Koeppen H, Gentleman R, Starr TK, Zhang Z, Largaespada DA, Wu TD, de Sauvage FJ", "evidence": [ { "database": "dbSNP", "id": "rs745621835", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745621835" } ], "reference": [ { "type": "PubMed", "id": "22895193", "url": "https://glygen.org/publication/PubMed/22895193" } ] }, { "title": "Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood samples.", "journal": "Molecular & cellular proteomics : MCP", "date": "2013", "authors": "Boersema PJ, Geiger T, Wisniewski JR, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "23090970", "url": "https://glygen.org/publication/PubMed/23090970" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.", "journal": "The Journal of pathology", "date": "2014", "authors": "Jiao Y, Yonescu R, Offerhaus GJ, Klimstra DS, Maitra A, Eshleman JR, Herman JG, Poh W, Pelosof L, Wolfgang CL, Vogelstein B, Kinzler KW, Hruban RH, Papadopoulos N, Wood LD", "evidence": [ { "database": "dbSNP", "id": "rs749392422", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs749392422" } ], "reference": [ { "type": "PubMed", "id": "24293293", "url": "https://glygen.org/publication/PubMed/24293293" } ] }, { "title": "Angiopoietin-like 7 is an anti-angiogenic protein required to prevent vascularization of the cornea.", "journal": "PloS one", "date": "2015", "authors": "Toyono T, Usui T, Yokoo S, Taketani Y, Nakagawa S, Kuroda M, Yamagami S, Amano S", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "25622036", "url": "https://glygen.org/publication/PubMed/25622036" } ] }, { "title": "Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity.", "journal": "Frontiers in endocrinology", "date": "2022", "authors": "Leentjens M, Alterki A, Abu-Farha M, Bosschieter PFN, de Raaff C, de Vries C, Al Shawaf E, Thanaraj TA, Al-Khairi I, Cherian P, Channanath A, Kavalakatt S, van Wagensveld BA, de Vries N, Abubaker J", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" } ], "reference": [ { "type": "PubMed", "id": "36017324", "url": "https://glygen.org/publication/PubMed/36017324" } ] }, { "title": "ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.", "journal": "Communications biology", "date": "2022", "authors": "Praveen K, Patel GC, Gurski L, Ayer AH, Persaud T, Still MD, Miloscio L, Van Zyl T, Di Gioia SA, Brumpton B, Krebs K, Asvold BO, Chen E, Chavali VRM, Fury W, Gudiseva HV, Hyde S, Jorgenson E, Lefebvre S, Li D, Li A, Mclninch J, Patel B, Rabinowitz JS, Salowe R, Schurmann C, Seidelin AS, Stahl E, Sun D, Teslovich TM, Tybjaerg-Hansen A, Willer C, Waldron S, Walley S, Yang H, Zaveri S, Hu Y, Hveem K, Melander O, Milani L, Stender S, O'Brien JM, Jones MB, Abecasis GR, Cantor MN, Weyne J, Karalis K, Economides A, Della Gatta G, Ferreira MA, Yancopoulos GD, Baras A, Romano C, Coppola G", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" } ], "reference": [ { "type": "PubMed", "id": "36192519", "url": "https://glygen.org/publication/PubMed/36192519" } ] }, { "title": "Metastasis from the tumor interior and necrotic core formation are regulated by breast cancer-derived angiopoietin-like 7.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2023-03-07", "authors": "Yamamoto Ami, Huang Yin, Krajina Brad A, McBirney Margaux, Doak Andrea E, Qu Sixuan, Wang Carolyn L, Haffner Michael C, Cheung Kevin J", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" } ], "reference": [ { "type": "PubMed", "id": "36853945", "url": "https://glygen.org/publication/PubMed/36853945" } ] }, { "title": "Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression.", "journal": "Human molecular genetics", "date": "2023-07-20", "authors": "Aboobakar Inas F, Collantes Edward Ryan A, Hauser Michael A, Stamer W Daniel, Wiggs Janey L", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" } ], "reference": [ { "type": "PubMed", "id": "37220876", "url": "https://glygen.org/publication/PubMed/37220876" } ] }, { "title": "The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.", "journal": "Blood", "date": "2023-09-07", "authors": "Fei Ming-Yue, Wang Yong, Chang Bin-He, Xue Kai, Dong Fangyi, Huang Dan, Li Xi-Ya, Li Zi-Juan, Hu Cheng-Long, Liu Ping, Wu Ji-Chuan, Yu Peng-Cheng, Hong Ming-Hua, Chen Shu-Bei, Xu Chun-Hui, Chen Bing-Yi, Jiang Yi-Lun, Liu Na, Zhao Chong, Jin Jia-Cheng, Hou Dan, Chen Xin-Chi, Ren Yi-Yi, Deng Chu-Han, Zhang Jia-Ying, Zong Li-Juan, Wang Rou-Jia, Gao Fei-Fei, Liu Hui, Zhang Qun-Ling, Wu Ling-Yun, Yan Jinsong, Shen Shuhong, Chang Chun-Kang, Sun Xiao-Jian, Wang Lan", "evidence": [ { "database": "RefSeq", "id": "NP_066969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066969" } ], "reference": [ { "type": "PubMed", "id": "37319434", "url": "https://glygen.org/publication/PubMed/37319434" } ] }, { "title": "Molecular cloning of a new angiopoietin-like factor from the human cornea.", "journal": "Invest. Ophthalmol. Vis. Sci.", "date": "1998", "authors": "Peek R, van Gelderen BE, Bruinenberg M, Kijlstra A", "evidence": [ { "database": "UniProtKB", "id": "O43827", "url": "https://www.uniprot.org/uniprot/O43827" } ], "reference": [ { "type": "PubMed", "id": "9727400", "url": "https://glygen.org/publication/PubMed/9727400" } ] } ], "pathway": [ { "id": "hsa:10218", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10218", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZDK4-1", "protein_name": "Angiopoietin like 7", "gene_name": "Angptl7", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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