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Binds the P5 DNA element sequence 5'-GATCTGAGTCTAATTGAGAATTACTGTAC-3'.", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812#function" }, { "database": "PubMed", "id": "9736770", "url": "https://glygen.org/publication/PubMed/9736770" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "common_name": "Human" } ], "gene": [ { "name": "DUX1", "url": "https://www.uniprot.org/uniprot/O43812", "locus": {} } ], "crossref": [ { "id": "cd00086", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00086", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DUX1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=DUX1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "26584", "url": "https://www.ncbi.nlm.nih.gov/gene/26584", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3079", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3079", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O43812", "url": "https://www.ebi.ac.uk/intact/interactors/id:O43812*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001356", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001356", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR009057", "url": "https://www.ebi.ac.uk/interpro/entry/IPR009057", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017970", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017970", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:26584", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:26584", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "611441", "url": "http://www.omim.org/entry/611441", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O43812", "url": "https://www.nextprot.org/entry/NX_O43812", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "PTHR46123", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46123", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR46123:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46123:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00046", "url": "http://pfam.xfam.org/family/PF00046", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O43812", "url": "https://pharos.nih.gov/targets/O43812", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O43812", "url": "http://purl.obolibrary.org/obo/PR_O43812", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_036278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036278", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43812-1", "url": "https://www.uniprot.org/uniprot/O43812-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG", "length": 170, "header": "sp|O43812-1|DUX1_HUMAN Isoform 1 of Double homeobox protein 1 OS=Homo sapiens OX=9606 GN=DUX1 PE=1 SV=1 CANONICAL=O43812-1" }, "isoforms": [ { "isoform_ac": "O43812-1", "url": "", "sequence": { "sequence": "MALLTALDDTLPEEAQGPGRRMILLSTPSQSDALRACFERNLYPGIATKEELAQGIDIPEPRVQIWFQNERSCQLRQHRRQSRPWPGRRDPQKGRRKRTAITGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHRGQSGRAPTQASIRCNAAPIG", "length": 170, "header": "sp|O43812-1|DUX1_HUMAN Isoform 1 of Double homeobox protein 1 OS=Homo sapiens OX=9606 GN=DUX1 PE=1 SV=1 CANONICAL=O43812-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Intracellular trafficking and dynamics of double homeodomain proteins.", "journal": "Biochemistry", "date": "2005", "authors": "Ostlund C, Garcia-Carrasquillo RM, Belayew A, Worman HJ", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "reference": [ { "type": "PubMed", "id": "15709750", "url": "https://glygen.org/publication/PubMed/15709750" } ] }, { "title": "Characterization of a double homeodomain protein (DUX1) encoded by a cDNA homologous to 3.3 kb dispersed repeated elements.", "journal": "Human molecular genetics", "date": "1998", "authors": "Ding H, Beckers MC, Plaisance S, Marynen P, Collen D, Belayew A", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "reference": [ { "type": "PubMed", "id": "9736770", "url": "https://glygen.org/publication/PubMed/9736770" } ] } ], "pathway": [ { "id": "hsa:26584", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:26584", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 1, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "regulation of transcription by RNA polymerase II", "id": "GO:0006357", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006357", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "id": "GO:0000977", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "pmid": "" }, { "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "pmid": "" }, { "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "evidence": [ { "database": "UniProtKB", "id": "O43812", "url": "https://www.uniprot.org/uniprot/O43812" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 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