{ "uniprot_canonical_ac": "O43795-1", "uniprot_ac": "O43795", "uniprot_id": "MYO1B_HUMAN", "mass": { "chemical_mass": 131985.0, "monoisotopic_mass": 131985.0 }, "refseq": { "ac": "NP_001123630", "name": "unconventional myosin-Ib isoform 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" }, "gene_names": [ { "name": "MYO1B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43795", "id": "O43795" }, { "name": "MMI-alpha; MMIa; MYH-1c; myr1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630", "id": "NP_001123630" }, { "name": "MYO1B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630", "id": "NP_001123630" } ], "protein_names": [ { "name": "Unconventional myosin-Ib", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43795" }, { "name": "MMI-alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43795" }, { "name": "MMIa", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43795" }, { "name": "MYH-1c", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43795" }, { "name": "Myosin I alpha", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43795" }, { "name": "myosin-I alpha; MYO1B variant protein; unconventional myosin-Ib", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630", "id": "NP_001123630" }, { "name": "unconventional myosin-Ib isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630", "id": "NP_001123630" } ], "function": [ { "annotation": "At apical surfaces of supporting cells that surround hair cells in auditory epithelia of postnatal rats. In vestibular epithelia, present in ring within apical pole of hair cell. Expression was prominent only immediately after birth.", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" }, { "database": "PubMed", "id": "12486594", "url": "https://glygen.org/publication/PubMed/12486594" } ] }, { "annotation": "CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma. 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Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" }, { "database": "PubMed", "id": "36654782", "url": "https://glygen.org/publication/PubMed/36654782" } ] }, { "annotation": "Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1alpha in colorectal cancer. 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": 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"MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast 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"description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O43795", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43795" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "common_name": "Human" } ], "gene": [ { "name": "MYO1B", "url": "https://www.uniprot.org/uniprot/O43795", "locus": { "chromosome": "2", "start_pos": 191425389, "end_pos": 191245185, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000128641", "url": "https://www.ensembl.org/id/ENSG00000128641" } ] } } ], "crossref": [ { "id": "ENSG00000128641", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000128641", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O43795", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43795", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd01378", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01378", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "MYO1B", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYO1B", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "4430", "url": "https://www.ncbi.nlm.nih.gov/gene/4430", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "7596", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7596", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "A0A0U1RRI3", "url": "https://www.ebi.ac.uk/intact/interactors/id:A0A0U1RRI3*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "E9PDF6", "url": "https://www.ebi.ac.uk/intact/interactors/id:E9PDF6*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "O43795", "url": "https://www.ebi.ac.uk/intact/interactors/id:O43795*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000048", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001609", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001609", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR010926", "url": "https://www.ebi.ac.uk/interpro/entry/IPR010926", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011993", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036072", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036072", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:4430", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4430", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "606537", "url": "http://www.omim.org/entry/606537", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O43795", "url": "https://www.nextprot.org/entry/NX_O43795", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O43795", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43795", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "PLYGNEY", "url": "https://omabrowser.org/oma/group/PLYGNEY/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1094820at2759", "url": "http://www.orthodb.org/?query=1094820at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR13140:SF277", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR13140:SF277", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34969", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34969", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR34969:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR34969:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00063", "url": "http://pfam.xfam.org/family/PF00063", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF00612", "url": "http://pfam.xfam.org/family/PF00612", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF06017", "url": "http://pfam.xfam.org/family/PF06017", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O43795", "url": "https://pharos.nih.gov/targets/O43795", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O43795", "url": "http://purl.obolibrary.org/obo/PR_O43795", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0U1RRI3", "url": "https://www.uniprot.org/uniprot/A0A0U1RRI3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0U1RRI3-1", "url": "https://www.uniprot.org/uniprot/A0A0U1RRI3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JUP5", "url": "https://www.uniprot.org/uniprot/C9JUP5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JUP5-1", "url": "https://www.uniprot.org/uniprot/C9JUP5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JYW1", "url": "https://www.uniprot.org/uniprot/C9JYW1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JYW1-1", "url": "https://www.uniprot.org/uniprot/C9JYW1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9K0I9", "url": "https://www.uniprot.org/uniprot/C9K0I9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9K0I9-1", "url": "https://www.uniprot.org/uniprot/C9K0I9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EQD9", "url": "https://www.uniprot.org/uniprot/E7EQD9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E7EQD9-1", "url": "https://www.uniprot.org/uniprot/E7EQD9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PDF6", "url": "https://www.uniprot.org/uniprot/E9PDF6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "E9PDF6-1", "url": "https://www.uniprot.org/uniprot/E9PDF6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C2Y7", "url": "https://www.uniprot.org/uniprot/H7C2Y7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C2Y7-1", "url": "https://www.uniprot.org/uniprot/H7C2Y7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43795-1", "url": "https://www.uniprot.org/uniprot/O43795-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43795-2", "url": "https://www.uniprot.org/uniprot/O43795-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP", "length": 1136, "header": "sp|O43795-1|MYO1B_HUMAN Isoform 1 of Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3 CANONICAL=O43795-1" }, "isoforms": [ { "isoform_ac": "A0A0U1RRI3-1", "url": "", "sequence": { "sequence": "XAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFENADNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDL", "length": 189, "header": "tr|A0A0U1RRI3-1|A0A0U1RRI3_HUMAN Computationally mapped isoform of Myosin IB OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=1 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191387284, "end_pos": 191369564, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000634375.1", "url": "https://www.ensembl.org/id/ENST00000634375.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000489544.1", "url": "https://www.ensembl.org/id/ENSP00000489544.1" } ] } }, { "isoform_ac": "C9JUP5-1", "url": "", "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVL", "length": 149, "header": "tr|C9JUP5-1|C9JUP5_HUMAN Computationally mapped isoform of Myosin IB OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=1 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191341561, "end_pos": 191276896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000438652.5", "url": "https://www.ensembl.org/id/ENST00000438652.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000399459.1", "url": "https://www.ensembl.org/id/ENSP00000399459.1" } ] } }, { "isoform_ac": "C9JYW1-1", "url": "", "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNS", "length": 163, "header": "tr|C9JYW1-1|C9JYW1_HUMAN Computationally mapped isoform of Myosin IB OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=1 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191346273, "end_pos": 191276896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000418908.5", "url": "https://www.ensembl.org/id/ENST00000418908.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000401324.1", "url": "https://www.ensembl.org/id/ENSP00000401324.1" } ] } }, { "isoform_ac": "C9K0I9-1", "url": "", "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPH", "length": 83, "header": "tr|C9K0I9-1|C9K0I9_HUMAN Computationally mapped isoform of Myosin IB OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=1 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191296224, "end_pos": 191276896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000420448.1", "url": "https://www.ensembl.org/id/ENST00000420448.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000387610.1", "url": "https://www.ensembl.org/id/ENSP00000387610.1" } ] } }, { "isoform_ac": "E7EQD9-1", "url": "", "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDK", "length": 303, "header": "tr|E7EQD9-1|MYO1B_HUMAN Computationally mapped isoform of Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=1 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191363871, "end_pos": 191276896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000451437.5", "url": "https://www.ensembl.org/id/ENST00000451437.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000388140.1", "url": "https://www.ensembl.org/id/ENSP00000388140.1" } ] } }, { "isoform_ac": "E9PDF6-1", "url": "", "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP", "length": 1107, "header": "tr|E9PDF6-1|E9PDF6_HUMAN Computationally mapped isoform of Myosin IB OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=1 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191423957, "end_pos": 191276896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000392316.5", "url": "https://www.ensembl.org/id/ENST00000392316.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000376130.1", "url": "https://www.ensembl.org/id/ENSP00000376130.1" } ] } }, { "isoform_ac": "H7C2Y7-1", "url": "", "sequence": { "sequence": "XCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEYVHVLFENPFSLSAFLF", "length": 192, "header": "tr|H7C2Y7-1|MYO1B_HUMAN Computationally mapped isoform of Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=1 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191416296, "end_pos": 191411065, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427152.1", "url": "https://www.ensembl.org/id/ENST00000427152.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000408454.1", "url": "https://www.ensembl.org/id/ENSP00000408454.1" } ] } }, { "isoform_ac": "O43795-1", "url": "", "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQARRELRRLKEEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP", "length": 1136, "header": "sp|O43795-1|MYO1B_HUMAN Isoform 1 of Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191423957, "end_pos": 191276896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000392318.8", "url": "https://www.ensembl.org/id/ENST00000392318.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000376132.3", "url": "https://www.ensembl.org/id/ENSP00000376132.3" } ] } }, { "isoform_ac": "O43795-2", "url": "", "sequence": { "sequence": "MAKMEVKTSLLDNMIGVGDMVLLEPLNEETFINNLKKRFDHSEIYTYIGSVVISVNPYRSLPIYSPEKVEEYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLNKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFMDHEAESVLAVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTGIDQSVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTSLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKASHALIKSLFPEGNPAKINLKRPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFNEALVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFKLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKKSQIVIAAWYRRYAQQKRYQQTKSSALVIQSYIRGWKARKILRELKHQKRCKEAVTTIAAYWHGTQVRREYRKFFRANAGKKIYEFTLQRIVQKYFLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP", "length": 1078, "header": "sp|O43795-2|MYO1B_HUMAN Isoform 2 of Unconventional myosin-Ib OS=Homo sapiens OX=9606 GN=MYO1B PE=1 SV=3 CANONICAL=O43795-1" }, "locus": { "chromosome": "2", "start_pos": 191423957, "end_pos": 191276896, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000339514.8", "url": "https://www.ensembl.org/id/ENST00000339514.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000341903.4", "url": "https://www.ensembl.org/id/ENSP00000341903.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 793, "start_aa": "Thr", "end_pos": 793, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr793", "evidence": [ { "id": "O43795", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43795" }, { "id": "34725712", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34725712" }, { "id": "35083852", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35083852" }, { "id": "34229054", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34229054" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "30397120", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30397120" } ] } ], "phosphorylation": [ { "start_pos": 60, "end_pos": 60, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "O43795", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43795" } ], "site_lbl": "Ser60" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Myosin-I isozymes in neonatal rodent auditory and vestibular epithelia.", "journal": "Journal of the Association for Research in Otolaryngology : JARO", "date": "2002", "authors": "Dumont RA, Zhao YD, Holt JR, Bahler M, Gillespie PG", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" } ], "reference": [ { "type": "PubMed", "id": "12486594", "url": "https://glygen.org/publication/PubMed/12486594" } ] }, { "title": "The consensus coding sequences of human breast and colorectal cancers.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "reference": [ { "type": "PubMed", "id": "16959974", "url": "https://glygen.org/publication/PubMed/16959974" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" }, { "database": "iPTMnet", "id": "O43795", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43795" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "2014", "authors": "Impens F, Radoshevich L, Cossart P, Ribet D", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "reference": [ { "type": "PubMed", "id": "25114211", "url": "https://glygen.org/publication/PubMed/25114211" } ] }, { "title": "Uncovering global SUMOylation signaling networks in a site-specific manner.", "journal": "Nat. Struct. Mol. Biol.", "date": "2014", "authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "reference": [ { "type": "PubMed", "id": "25218447", "url": "https://glygen.org/publication/PubMed/25218447" } ] }, { "title": "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.", "journal": "Mol. Cell. Proteomics", "date": "2015", "authors": "Xiao Zhenyu, Chang Jer-Gung, Hendriks Ivo A, Sigur\u00f0sson J\u00f3n Otti, Olsen Jesper V, Vertegaal Alfred C O", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "reference": [ { "type": "PubMed", "id": "25755297", "url": "https://glygen.org/publication/PubMed/25755297" } ] }, { "title": "Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBalpha complex.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2018", "authors": "Berthier A, Vinod M, Porez G, Steenackers A, Alexandre J, Yamakawa N, Gheeraert C, Ploton M, Marechal X, Dubois-Chevalier J, Hovasse A, Schaeffer-Reiss C, Cianferani S, Rolando C, Bray F, Duez H, Eeckhoute J, Lefebvre T, Staels B, Lefebvre P", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43795", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43795" } ], "reference": [ { "type": "PubMed", "id": "30397120", "url": "https://glygen.org/publication/PubMed/30397120" } ] }, { "title": "Synthesis of Na2S2O4 mediated cleavable affinity tag for labeling of O-GlcNAc modified proteins via azide-alkyne cycloaddition.", "journal": "Bioorganic & medicinal chemistry letters", "date": "2021", "authors": "Wang J, Dou B, Zheng L, Cao W, Zeng X, Wen Y, Ma J, Li X", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43795", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43795" } ], "reference": [ { "type": "PubMed", "id": "34229054", "url": "https://glygen.org/publication/PubMed/34229054" } ] }, { "title": "Truncation of the TPR domain of OGT alters substrate and glycosite selection.", "journal": "Analytical and bioanalytical chemistry", "date": "2021", "authors": "Ramirez DH, Yang B, D'Souza AK, Shen D, Woo CM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43795", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43795" } ], "reference": [ { "type": "PubMed", "id": "34725712", "url": "https://glygen.org/publication/PubMed/34725712" } ] }, { "title": "O-GlcNAcylation promotes fatty acid synthase activity under nutritional stress as a pro-survival mechanism in cancer cells.", "journal": "Proteomics", "date": "2022", "authors": "Wong YK, Wang J, Lim TK, Lin Q, Yap CT, Shen HM", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43795", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43795" } ], "reference": [ { "type": "PubMed", "id": "35083852", "url": "https://glygen.org/publication/PubMed/35083852" } ] }, { "title": "Targeting MYO1B impairs tumorigenesis via inhibiting the SNAI2/cyclin D1 signaling in esophageal squamous cell carcinoma.", "journal": "Journal of cellular physiology", "date": "2022-09", "authors": "Li Shau-Hsuan, Qian Limei, Chen Yen-Hao, Lu Hung-I, Tsai Hsin-Ting, Lyu Haiwen, Yang Runxiang, Chen Chang-Han", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" } ], "reference": [ { "type": "PubMed", "id": "35861939", "url": "https://glygen.org/publication/PubMed/35861939" } ] }, { "title": "Myo1b promotes tumor progression and angiogenesis by inhibiting autophagic degradation of HIF-1\u03b1 in colorectal cancer.", "journal": "Cell death & disease", "date": "2022-11-08", "authors": "Chen Yi-Hong, Xu Nan-Zhu, Hong Chang, Li Wen-Qi, Zhang Yi-Qiong, Yu Xin-Yi, Huang Yue-Le, Zhou Jue-Yu", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" } ], "reference": [ { "type": "PubMed", "id": "36347835", "url": "https://glygen.org/publication/PubMed/36347835" } ] }, { "title": "Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.", "journal": "Oxidative medicine and cellular longevity", "date": "2023", "authors": "Yu Yi, Ren Yuanyuan, Li Zi, Li Yang, Li Yirong, Zhang Yan, Gui Runlin, Cui Yue, Qian Lu, Xiong Yuyan", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" } ], "reference": [ { "type": "PubMed", "id": "36654782", "url": "https://glygen.org/publication/PubMed/36654782" } ] }, { "title": "MYO1B as a prognostic biomarker and a therapeutic target in Arecoline-associated oral carcinoma.", "journal": "Molecular carcinogenesis", "date": "2023-04-04", "authors": "Sun Zhen, Guo Xiaopeng, Chen Huarong, Ling Junjun, Zhao Houyu, Chang Aoshuang, Zhuo Xianlu", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" } ], "reference": [ { "type": "PubMed", "id": "37014156", "url": "https://glygen.org/publication/PubMed/37014156" } ] }, { "title": "CCND1-associated ceRNA network reveal the critical pathway of TPRG1-AS1-hsa-miR-363-3p-MYO1B as a prognostic marker for head and neck squamous cell carcinoma.", "journal": "Scientific reports", "date": "2023-07-22", "authors": "Li Zehao, Qiu Xinguang, He Qi, Fu Xinghao, Ji Feihong, Tian Xiufen", "evidence": [ { "database": "RefSeq", "id": "NP_001123630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123630" } ], "reference": [ { "type": "PubMed", "id": "37481637", "url": "https://glygen.org/publication/PubMed/37481637" } ] }, { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43795", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43795" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "pathway": [ { "id": "hsa:4430", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4430", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P46735-1", "protein_name": "Unconventional myosin-Ib", "gene_name": "Myo1b", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAKMEVKSSLLDNMIGVGDMVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQSNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFYQLLSGASEELLYKLKLERDFSRYNYLSLDSAKVNGVDDAANFRTVRNAMQIVGFLDHEAEAVLEVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKAQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHSLIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMRNLQTKNPNYIRCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKGPARSGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKEAATTIAAYWHGTQARRELKRLKEEARRKHAVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKELKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPKYKKLKDAIEEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDVTKVSMSSQNDGFFAVHLKEGSEAASKGDFLFSSDHLIEMATKLYRTTLSQTKQKLNIEISDEFLVQFRQDKVCVKFIQGNQKNGSVPTCKRKNNRLLEVAVP", "length": 1107 }, "evidence": [ { "id": "45924225", "url": "http://www.informatics.jax.org/homology/45924225", "database": "MGI" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "Q05096-1", "protein_name": "Unconventional myosin-Ib", "gene_name": "Myo1b", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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"length": 1136 }, "evidence": [ { "id": "45924225", "url": "http://www.informatics.jax.org/homology/45924225", "database": "MGI" }, { "id": "O43795", "url": "https://omabrowser.org/oma/group/O43795/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 9, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "cytoskeletal motor activity", "id": "GO:0003774", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003774", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "actin binding", "id": "GO:0003779", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "calmodulin binding", "id": "GO:0005516", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005516", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "phosphatidylinositol-4,5-bisphosphate binding", "id": "GO:0005546", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005546", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "phosphatidylinositol-3,4,5-trisphosphate binding", "id": "GO:0005547", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005547", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "actin filament binding", "id": "GO:0051015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "cadherin binding", "id": "GO:0045296", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045296", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "microfilament motor activity", "id": "GO:0000146", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000146", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 15, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "myosin complex", "id": "GO:0016459", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016459", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "early endosome", "id": "GO:0005769", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "actin filament", "id": "GO:0005884", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005884", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "brush border", "id": "GO:0005903", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "actin cytoskeleton", "id": "GO:0015629", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015629", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "apical part of cell", "id": "GO:0045177", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "perinuclear region of cytoplasm", "id": "GO:0048471", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "endosome membrane", "id": "GO:0010008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010008", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "filopodium", "id": "GO:0030175", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "vesicle", "id": "GO:0031982", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031982", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "cell periphery", "id": "GO:0071944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071944", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "microvillus", "id": "GO:0005902", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005902", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 5, "go_terms": [ { "name": "actin filament organization", "id": "GO:0007015", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "actin filament bundle assembly", "id": "GO:0051017", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051017", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "actin filament-based movement", "id": "GO:0030048", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030048", "evidence": [ { "database": "UniProtKB", "id": "O43795", "url": "https://www.uniprot.org/uniprot/O43795" } ], "pmid": "" }, { "name": "post-Golgi vesicle-mediated transport", "id": "GO:0006892", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006892", 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