{ "uniprot_canonical_ac": "O43752-1", "uniprot_ac": "O43752", "uniprot_id": "STX6_HUMAN", "mass": { "chemical_mass": 29176.0, "monoisotopic_mass": 29176.0 }, "refseq": { "ac": "NP_001273139", "name": "syntaxin-6 isoform 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273139" }, "gene_names": [ { "name": "STX6", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43752", "id": "O43752" }, { "name": "STX6", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273139", "id": "NP_001273139" } ], "protein_names": [ { "name": "Syntaxin-6", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43752" }, { "name": "syntaxin-6 isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273139", "id": "NP_001273139" } ], "function": [ { "annotation": "Human Cytomegalovirus Manipulates Syntaxin 6 for Successful Trafficking and Subsequent Infection of Monocytes.", "evidence": [ { "database": "RefSeq", "id": "NP_001273139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273139" }, { "database": "PubMed", "id": "35862696", "url": "https://glygen.org/publication/PubMed/35862696" } ] }, { "annotation": "N[6] -methyladenosine-modified circSTX6 promotes hepatocellular carcinoma progression by regulating the HNRNPD/ATF3 axis and encoding a 144 amino acid polypeptide.", "evidence": [ { "database": "RefSeq", "id": "NP_001273139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273139" }, { "database": "PubMed", "id": "37877357", "url": "https://glygen.org/publication/PubMed/37877357" } ] }, { "annotation": "SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway.", "evidence": [ { "database": "UniProtKB", "id": "O43752", "url": "https://www.uniprot.org/uniprot/O43752#function" }, { "database": "UniProtKB", "id": "Q63635", "url": "https://www.uniprot.org/uniprot/Q63635#function" } ] }, { "annotation": "Syntaxin 6 Enhances the Progression of Epithelial Ovarian Cancer by Promoting Cancer Cell Proliferation. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001273139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273139" }, { "database": "PubMed", "id": "37378930", "url": "https://glygen.org/publication/PubMed/37378930" } ] }, { "annotation": "Syntaxin-6 promotes the progression of hepatocellular carcinoma and alters its sensitivity to chemotherapies by activating the USF2/LC3B axis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001273139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273139" }, { "database": "PubMed", "id": "37564208", "url": "https://glygen.org/publication/PubMed/37564208" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "78.91", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000135823", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135823" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "85.09", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000135823", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135823" } ] }, { "tissue": { "name": "Stomach", "namespace": 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"present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000135823", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135823" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "52.98", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000135823", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135823" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "85.26", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000135823", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000135823" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "83.25", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000135823", "url": 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"description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", 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"id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O43752", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43752" } ], "site_lbl": "Ser152" }, { "start_pos": 2, "end_pos": 2, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43752", "url": "https://www.uniprot.org/uniprot/O43752" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O43752", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43752" }, { "database": "PubMed", "id": "18578522", "url": "https://glygen.org/publication/PubMed/18578522" } ], "site_lbl": "Ser2" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1.", "journal": "J. Leukoc. Biol.", "date": "1999", "authors": "Mart\u00edn-Mart\u00edn B, Nabokina S M, Lazo P A, Mollinedo F", "evidence": [ { "database": "UniProtKB", "id": "O43752", "url": "https://www.uniprot.org/uniprot/O43752" } ], "reference": [ { "type": "PubMed", "id": "10080545", "url": "https://glygen.org/publication/PubMed/10080545" } ] }, { "title": "GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein.", "journal": "The Journal of cell biology", "date": "1999", "authors": "Infante C, Ramos-Morales F, Fedriani C, Bornens M, Rios RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811438" } ], "reference": [ { "type": "PubMed", "id": "10189370", "url": "https://glygen.org/publication/PubMed/10189370" } ] }, { "title": "A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins.", "journal": "Current biology : CB", "date": "1999", "authors": "Barr FA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "10209123", "url": "https://glygen.org/publication/PubMed/10209123" } ] }, { "title": "NSF N-terminal domain crystal structure: models of NSF function.", "journal": "Molecular cell", "date": "1999", "authors": "Yu RC, Jahn R, Brunger AT", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "10445031", "url": "https://glygen.org/publication/PubMed/10445031" } ] }, { "title": "An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion.", "journal": "Nature cell biology", "date": "1999", "authors": "Muller JM, Rabouille C, Newman R, Shorter J, Freemont P, Schiavo G, Warren G, Shima DT", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "10559959", "url": "https://glygen.org/publication/PubMed/10559959" } ] }, { "title": "Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi.", "journal": "Molecular biology of the cell", "date": "2000", "authors": "Conibear E, Stevens TH", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "10637310", "url": "https://glygen.org/publication/PubMed/10637310" } ] }, { "title": "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Ogasawara M, Kim SC, Adamik R, Togawa A, Ferrans VJ, Takeda K, Kirby M, Moss J, Vaughan M", "evidence": [ { 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"id": "10865125", "url": "https://glygen.org/publication/PubMed/10865125" } ] }, { "title": "Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p.", "journal": "The EMBO journal", "date": "2000", "authors": "Siniossoglou S, Peak-Chew SY, Pelham HR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "10990452", "url": "https://glygen.org/publication/PubMed/10990452" } ] }, { "title": "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "11303027", "url": "https://glygen.org/publication/PubMed/11303027" } ] }, { "title": "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.", "journal": "Nature", "date": "2001", "authors": "Tarricone C, Xiao B, Justin N, Walker PA, Rittinger K, Gamblin SJ, Smerdon SJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "11346801", "url": "https://glygen.org/publication/PubMed/11346801" } ] }, { "title": "Role of Rab9 GTPase in facilitating receptor recruitment by TIP47.", "journal": "Science (New York, N.Y.)", "date": "2001", "authors": "Carroll KS, Hanna J, Simon I, Krise J, Barbero P, Pfeffer SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "11359012", "url": "https://glygen.org/publication/PubMed/11359012" } ] }, { "title": "Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6.", "journal": "J. 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Chem.", "date": "2001", "authors": "Charest A, Lane K, McMahon K, Housman DE", "evidence": [ { "database": "UniProtKB", "id": "O43752", "url": "https://www.uniprot.org/uniprot/O43752" } ], "reference": [ { "type": "PubMed", "id": "11384996", "url": "https://glygen.org/publication/PubMed/11384996" } ] }, { "title": "An effector of Ypt6p binds the SNARE Tlg1p and mediates selective fusion of vesicles with late Golgi membranes.", "journal": "The EMBO journal", "date": "2001", "authors": "Siniossoglou S, Pelham HR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "11689439", "url": "https://glygen.org/publication/PubMed/11689439" } ] }, { "title": "Identification of rabaptin-5, rabex-5, and GM130 as putative effectors of rab33b, a regulator of retrograde traffic between the Golgi apparatus and ER.", "journal": "FEBS letters", "date": "2001", "authors": "Valsdottir R, Hashimoto H, Ashman K, Koda T, Storrie B, Nilsson T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811438" } ], "reference": [ { "type": "PubMed", "id": "11718716", "url": "https://glygen.org/publication/PubMed/11718716" } ] }, { "title": "Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1.", "journal": "The Journal of cell biology", "date": "2001", "authors": "Lanoix J, Ouwendijk J, Stark A, Szafer E, Cassel D, Dejgaard K, Weiss M, Nilsson T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811438" } ], "reference": [ { "type": "PubMed", "id": "11748249", "url": "https://glygen.org/publication/PubMed/11748249" } ] }, { "title": "Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Barbero P, Bittova L, Pfeffer SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "11827983", "url": "https://glygen.org/publication/PubMed/11827983" } ] }, { "title": "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform.", "journal": "The Journal of cell biology", "date": "2002", "authors": "Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "11839770", "url": "https://glygen.org/publication/PubMed/11839770" } ] }, { "title": "The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.", "journal": "The 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"date": "2002", "authors": "Siniossoglou S, Pelham HR", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "12377769", "url": "https://glygen.org/publication/PubMed/12377769" } ] }, { "title": "The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus.", "journal": "Traffic (Copenhagen, Denmark)", "date": "2002", "authors": "Pernet-Gallay K, Antony C, Johannes L, Bornens M, Goud B, Rios RM", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811438" } ], "reference": [ { "type": "PubMed", "id": "12383348", "url": "https://glygen.org/publication/PubMed/12383348" } ] }, { "title": "CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin.", "journal": "Molecular biology of the cell", "date": "2002", "authors": "Gillingham AK, Pfeifer AC, Munro S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811438", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811438" } ], "reference": [ { "type": "PubMed", "id": "12429822", "url": "https://glygen.org/publication/PubMed/12429822" } ] }, { "title": "Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3.", "journal": "Current biology : CB", "date": "2003", "authors": "Setty SR, Shin ME, Yoshino A, Marks MS, Burd CG", "evidence": [ { "database": "Reactome", "id": "R-HSA-6811440", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6811440" } ], "reference": [ { "type": "PubMed", "id": "12620188", "url": "https://glygen.org/publication/PubMed/12620188" } ] }, { "title": "The ARF-like GTPases Arl1p and Arl3p act in a pathway that interacts with vesicle-tethering factors at the Golgi apparatus.", "journal": "Current biology : 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