{ "uniprot_canonical_ac": "O43679-1", "uniprot_ac": "O43679", "uniprot_id": "LDB2_HUMAN", "mass": { "chemical_mass": 42793.0, "monoisotopic_mass": 42793.0 }, "refseq": { "ac": "NP_001124306", "name": "LIM domain-binding protein 2 isoform b", "summary": "The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" }, "gene_names": [ { "name": "LDB2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43679", "id": "O43679" }, { "name": "CLIM1; LDB-2; LDB1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306", "id": "NP_001124306" }, { "name": "CLIM1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43679", "id": "O43679" }, { "name": "LDB2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306", "id": "NP_001124306" }, { "name": "hCG_1811661", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43679", "id": "O43679" } ], "protein_names": [ { "name": "LIM domain-binding protein 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43679" }, { "name": "CLIM-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43679" }, { "name": "Carboxyl-terminal LIM domain-binding protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43679" }, { "name": "LDB-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43679" }, { "name": "LIM domain-binding factor CLIM1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43679" }, { "name": "LIM domain-binding factor-2; LIM binding domain 2; LIM domain-binding protein 2; LIM domain-binding factor CLIM1; carboxyl-terminal LIM domain-binding protein 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306", "id": "NP_001124306" }, { "name": "LIM domain-binding protein 2 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306", "id": "NP_001124306" } ], "function": [ { "annotation": "Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia.", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" }, { "database": "PubMed", "id": "33656268", "url": "https://glygen.org/publication/PubMed/33656268" } ] }, { "annotation": "LDB2 was the most connected gene in a transcription factor regulatory network inferred from transendothelial migration of leukocyte and atherosclerosis module genes in coronary and carotid artery disease macrophages.", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" }, { "database": "PubMed", "id": "24925974", "url": "https://glygen.org/publication/PubMed/24925974" } ] }, { "annotation": "LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" }, { "database": "PubMed", "id": "36473369", "url": "https://glygen.org/publication/PubMed/36473369" } ] }, { "annotation": "The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" } ] }, { "annotation": "Transcription cofactor. Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors.", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679#function" }, { "database": "UniProtKB", "id": "O55203", "url": "https://www.uniprot.org/uniprot/O55203#function" } ] }, { "annotation": "[LIM-domain binding protein 2 regulated by m(6)A modification inhibits lung adenocarcinoma cell proliferation in vitro].", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" }, { "database": "PubMed", "id": "33849822", "url": "https://glygen.org/publication/PubMed/33849822" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O43679", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43679" } ], "glycoeffect": [], "start_pos": 257, "end_pos": 257, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "R", "sequence_mut": 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"MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYRTKNLRPIGEKMNINGKCYRQDPHPPLL", "length": 106, "header": "tr|E9PGU0-1|LDB2_HUMAN Computationally mapped isoform of LIM domain-binding protein 2 OS=Homo sapiens OX=9606 GN=LDB2 PE=1 SV=1 CANONICAL=O43679-1" }, "locus": { "chromosome": "4", "start_pos": 16898485, "end_pos": 16595845, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000512345.5", "url": "https://www.ensembl.org/id/ENST00000512345.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000424676.1", "url": "https://www.ensembl.org/id/ENSP00000424676.1" } ] } }, { "isoform_ac": "G5E9Y7-1", "url": "", "sequence": { "sequence": "MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENPPPQASQ", "length": 371, "header": "tr|G5E9Y7-1|LDB2_HUMAN Computationally mapped isoform of LIM domain-binding protein 2 OS=Homo sapiens OX=9606 GN=LDB2 PE=1 SV=1 CANONICAL=O43679-1" }, "locus": { "chromosome": "4", "start_pos": 16898485, "end_pos": 16502646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000515064.5", "url": "https://www.ensembl.org/id/ENST00000515064.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000422552.1", "url": "https://www.ensembl.org/id/ENSP00000422552.1" } ] } }, { "isoform_ac": "H0YA09-1", "url": "", "sequence": { "sequence": "XIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENPPPQASQ", "length": 294, "header": "tr|H0YA09-1|LDB2_HUMAN Computationally mapped isoform of LIM domain-binding protein 2 OS=Homo sapiens OX=9606 GN=LDB2 PE=1 SV=1 CANONICAL=O43679-1" }, "locus": { "chromosome": "4", "start_pos": 16595875, "end_pos": 16502645, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000507464.5", "url": "https://www.ensembl.org/id/ENST00000507464.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000425754.1", "url": "https://www.ensembl.org/id/ENSP00000425754.1" } ] } }, { "isoform_ac": "O43679-1", "url": "", "sequence": { "sequence": "MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENPPPQASQ", "length": 373, "header": "sp|O43679-1|LDB2_HUMAN Isoform 1 of LIM domain-binding protein 2 OS=Homo sapiens OX=9606 GN=LDB2 PE=1 SV=1 CANONICAL=O43679-1" }, "locus": { "chromosome": "4", "start_pos": 16898485, "end_pos": 16502646, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000304523.10", "url": "https://www.ensembl.org/id/ENST00000304523.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000306772.5", "url": "https://www.ensembl.org/id/ENSP00000306772.5" } ] } }, { "isoform_ac": "O43679-2", "url": "", "sequence": { "sequence": "MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPGLGAIPNCSLNPGRDGDLCHSTAVTPSGQFKEKH", "length": 331, "header": "sp|O43679-2|LDB2_HUMAN Isoform 2 of LIM domain-binding protein 2 OS=Homo sapiens OX=9606 GN=LDB2 PE=1 SV=1 CANONICAL=O43679-1" }, "locus": { "chromosome": "4", "start_pos": 16898485, "end_pos": 16505881, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000441778.6", "url": "https://www.ensembl.org/id/ENST00000441778.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000392089.2", "url": "https://www.ensembl.org/id/ENSP00000392089.2" } ] } }, { "isoform_ac": "O43679-3", "url": "", "sequence": { "sequence": "MVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENPPPQASQ", "length": 347, "header": "sp|O43679-3|LDB2_HUMAN Isoform 3 of LIM domain-binding protein 2 OS=Homo sapiens OX=9606 GN=LDB2 PE=1 SV=1 CANONICAL=O43679-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O43679", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43679" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain.", "journal": "J. Biochem.", "date": "2006", "authors": "Tran YH, Xu Z, Kato A, Mistry AC, Goya Y, Taira M, Brandt SJ, Hirose S", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "reference": [ { "type": "PubMed", "id": "16815859", "url": "https://glygen.org/publication/PubMed/16815859" } ] }, { "title": "Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis.", "journal": "Arteriosclerosis, thrombosis, and vascular biology", "date": "2014", "authors": "Shang MM, Talukdar HA, Hofmann JJ, Niaudet C, Asl HF, Jain RK, Rossignoli A, Cedergren C, Silveira A, Gigante B, Leander K, de Faire U, Hamsten A, Ruusalepp A, Melander O, Ivert T, Michoel T, Schadt EE, Betsholtz C, Skogsberg J, Bjorkegren JL", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" } ], "reference": [ { "type": "PubMed", "id": "24925974", "url": "https://glygen.org/publication/PubMed/24925974" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43679", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43679" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia.", "journal": "EMBO molecular medicine", "date": "2021", "authors": "Ohnishi T, Kiyama Y, Arima-Yoshida F, Kadota M, Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, Nozaki Y, Kurokawa R, Suzuki K, Yoshikawa A, Toyota T, Hosoya T, Okuno H, Bito H, Itokawa M, Kuraku S, Manabe T, Yoshikawa T", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" } ], "reference": [ { "type": "PubMed", "id": "33656268", "url": "https://glygen.org/publication/PubMed/33656268" } ] }, { "title": "[LIM-domain binding protein 2 regulated by m(6)A modification inhibits lung adenocarcinoma cell proliferation in vitro].", "journal": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University", "date": "2021", "authors": "Zhai D, Wang G, Li L, Jia X, Zheng G, Yin J", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" } ], "reference": [ { "type": "PubMed", "id": "33849822", "url": "https://glygen.org/publication/PubMed/33849822" } ] }, { "title": "LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells.", "journal": "Clinics (Sao Paulo, Brazil)", "date": "2023", "authors": "Chu Fuying, Xu Xinxin, Zhang Yan, Cai Hua, Peng Jingjing, Li Yanan, Zhang Han, Liu Hongli, Chen Xiang", "evidence": [ { "database": "RefSeq", "id": "NP_001124306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124306" } ], "reference": [ { "type": "PubMed", "id": "36473369", "url": "https://glygen.org/publication/PubMed/36473369" } ] }, { "title": "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.", "journal": "Mamm. Genome", "date": "1998", "authors": "Semina EV, Altherr MR, Murray JC", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "reference": [ { "type": "PubMed", "id": "9799849", "url": "https://glygen.org/publication/PubMed/9799849" } ] }, { "title": "Selection system for genes encoding nuclear-targeted proteins.", "journal": "Nat. Biotechnol.", "date": "1998", "authors": "Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "reference": [ { "type": "PubMed", "id": "9853615", "url": "https://glygen.org/publication/PubMed/9853615" } ] } ], "pathway": [ { "id": "hsa:9079", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9079", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A0G2K287-1", "protein_name": "LIM domain binding 2", "gene_name": "Ldb2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCAMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNTTNSAGSKKKTTAASLSLSTQVPGLGAIPNCSLNPGRDGDLCHSTAVTPSGQFKEKH", "length": 331 }, "evidence": [ { "id": "45916692", "url": "http://www.informatics.jax.org/homology/45916692", "database": "MGI" }, { "id": "O43679", "url": "https://omabrowser.org/oma/group/O43679/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "O55203-1", "protein_name": "LIM domain-binding protein 2", "gene_name": "Ldb2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCAMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNTTNSAGSKKKTPAASLSLATQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENAPPQASQ", "length": 373 }, "evidence": [ { "id": "45916692", "url": "http://www.informatics.jax.org/homology/45916692", "database": "MGI" }, { "id": "O43679", "url": "https://omabrowser.org/oma/group/O43679/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 6, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "nucleolus", "id": "GO:0005730", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "cell leading edge", "id": "GO:0031252", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031252", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "transcription regulator complex", "id": "GO:0005667", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005667", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 10, "go_terms": [ { "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "nervous system development", "id": "GO:0007399", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "regulation of cell migration", "id": "GO:0030334", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030334", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "hair follicle development", "id": "GO:0001942", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001942", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "somatic stem cell population maintenance", "id": "GO:0035019", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035019", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "epithelial structure maintenance", "id": "GO:0010669", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010669", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "regulation of kinase activity", "id": "GO:0043549", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043549", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "positive regulation of cellular component biogenesis", "id": "GO:0044089", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044089", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "cellular component biogenesis", "id": "GO:0044085", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044085", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "enzyme binding", "id": "GO:0019899", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019899", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "LIM domain binding", "id": "GO:0030274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030274", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" }, { "name": "transcription coregulator activity", "id": "GO:0003712", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003712", "evidence": [ { "database": "UniProtKB", "id": "O43679", "url": "https://www.uniprot.org/uniprot/O43679" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 113, "end_pos": 115, "annotation": "n_glycosylation_sequon" }, { "start_pos": 190, "end_pos": 192, "annotation": "n_glycosylation_sequon" }, { "start_pos": 198, "end_pos": 200, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 262, "end_pos": 264, "annotation": "n_glycosylation_sequon" }, { "start_pos": 269, "end_pos": 271, "annotation": "n_glycosylation_sequon" }, { "start_pos": 277, "end_pos": 279, "annotation": "n_glycosylation_sequon" }, { "start_pos": 289, "end_pos": 291, "annotation": "n_glycosylation_sequon" }, { "start_pos": 341, "end_pos": 343, "annotation": "n_glycosylation_sequon" }, { "start_pos": 348, "end_pos": 350, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 257, 326, 345 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 113, "end_pos": 115 }, { "start_pos": 190, "end_pos": 192 }, { "start_pos": 198, "end_pos": 200 }, { "start_pos": 224, "end_pos": 226 }, { "start_pos": 262, 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