{ "uniprot_canonical_ac": "O43447-1", "uniprot_ac": "O43447", "uniprot_id": "PPIH_HUMAN", "mass": { "chemical_mass": 19208.0, "monoisotopic_mass": 19208.0 }, "refseq": { "ac": "NP_001317439", "name": "peptidyl-prolyl cis-trans isomerase H isoform 2", "summary": "The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439" }, "gene_names": [ { "name": "PPIH", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43447", "id": "O43447" }, { "name": "CYP-20; CYPH; SnuCyp-20; USA-CYP", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439", "id": "NP_001317439" }, { "name": "CYP20", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43447", "id": "O43447" }, { "name": "CYPH", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43447", "id": "O43447" }, { "name": "PPIH", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439", "id": "NP_001317439" }, { "name": "hCG_21746", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43447", "id": "O43447" } ], "protein_names": [ { "name": "Peptidyl-prolyl cis-trans isomerase H", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43447" }, { "name": "5.2.1.8", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43447" }, { "name": "CypH", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43447" }, { "name": "PPIase H", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43447" }, { "name": "Rotamase H", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43447" }, { "name": "Small nuclear ribonucleoprotein particle-specific cyclophilin H", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43447" }, { "name": "U-snRNP-associated cyclophilin SnuCyp-20", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43447" }, { "name": "USA-CYP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43447" }, { "name": "USA-CyP SnuCyp-20; cyclophilin H; U-snRNP-associated cyclophilin SunCyp-20; small nuclear ribonucleoprotein particle-specific cyclophilin H; rotamase H; peptidyl-prolyl cis-trans isomerase H; PPIase h; U-snRNP-associated cyclophilin SnuCyp-20", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439", "id": "NP_001317439" }, { "name": "peptidyl-prolyl cis-trans isomerase H isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439", "id": "NP_001317439" } ], "function": [ { "annotation": "Free and complexed cyclophilin H have virtually identical conformations suggesting that the U4/U6-60K binding site is pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is unaffected by complex formation", "evidence": [ { "database": "RefSeq", "id": "NP_001317439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439" }, { "database": "PubMed", "id": "12875835", "url": "https://glygen.org/publication/PubMed/12875835" } ] }, { "annotation": "PPIH gene regulation system and its prognostic significance in hepatocellular carcinoma: a comprehensive analysis.", "evidence": [ { "database": "RefSeq", "id": "NP_001317439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439" }, { "database": "PubMed", "id": "37874737", "url": "https://glygen.org/publication/PubMed/37874737" } ] }, { "annotation": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447#function" }, { "database": "PubMed", "id": "9570313", "url": "https://glygen.org/publication/PubMed/9570313" }, { "database": "PubMed", "id": "11823439", "url": "https://glygen.org/publication/PubMed/11823439" }, { "database": "PubMed", "id": "12875835", "url": "https://glygen.org/publication/PubMed/12875835" }, { "database": "PubMed", "id": "20676357", "url": "https://glygen.org/publication/PubMed/20676357" } ] }, { "annotation": "PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.", "evidence": [ { "database": "UniProtKB", "id": "A0A7I2V2H6", "url": "https://www.uniprot.org/uniprot/A0A7I2V2H6#function" }, { "database": "UniProtKB", "id": "RU363019", "url": "https://www.uniprot.org/uniprot/RU363019#function" }, { "database": "UniProtKB", "id": "A0A7I2V343", "url": "https://www.uniprot.org/uniprot/A0A7I2V343#function" }, { "database": "UniProtKB", "id": "C9JQD4", "url": "https://www.uniprot.org/uniprot/C9JQD4#function" }, { "database": "UniProtKB", "id": "H0YEL5", "url": "https://www.uniprot.org/uniprot/H0YEL5#function" }, { "database": "UniProtKB", "id": "A0A7I2YQS4", "url": "https://www.uniprot.org/uniprot/A0A7I2YQS4#function" } ] }, { "annotation": "The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001317439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 133, "end_pos": 133, "sequence_org": "W", "sequence_mut": "F", "comment": "Abolishes inhibition by cyclosporin A.", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" }, { "database": "PubMed", "id": "11823439", "url": "https://glygen.org/publication/PubMed/11823439" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "81.48", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "88.08", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.28", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "87.68", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "92.37", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "95.06", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "83.98", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "88.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "92.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "76.48", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "83.11", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.23", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "91.84", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000171960", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000171960" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O43447", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43447" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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}, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O43447", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43447" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O43447", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43447" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O43447", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43447" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43447" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": 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"UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JQD4", "url": "https://www.uniprot.org/uniprot/C9JQD4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "C9JQD4-1", "url": "https://www.uniprot.org/uniprot/C9JQD4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YEL5", "url": "https://www.uniprot.org/uniprot/H0YEL5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H0YEL5-1", "url": "https://www.uniprot.org/uniprot/H0YEL5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43447-1", "url": "https://www.uniprot.org/uniprot/O43447-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43447-2", "url": "https://www.uniprot.org/uniprot/O43447-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM", "length": 177, "header": "sp|O43447-1|PPIH_HUMAN Isoform 1 of Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "isoforms": [ { "isoform_ac": "A0A7I2V2H6-1", "url": "", "sequence": { "sequence": "MKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNMESRSVAQAGVQWCDLGLLQPPPPGWVQAILVPQPPE", "length": 92, "header": "tr|A0A7I2V2H6-1|PPIH_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "locus": { "chromosome": "1", "start_pos": 42663528, "end_pos": 42658856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000678076.1", "url": "https://www.ensembl.org/id/ENST00000678076.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502912.1", "url": "https://www.ensembl.org/id/ENSP00000502912.1" } ] } }, { "isoform_ac": "A0A7I2V343-1", "url": "", "sequence": { "sequence": "MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNMESRSVAQAGVQWCDLGLLQPPPPGWVQAILVPQPPE", "length": 118, "header": "tr|A0A7I2V343-1|A0A7I2V343_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "locus": { "chromosome": "1", "start_pos": 42663528, "end_pos": 42658447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000678193.1", "url": "https://www.ensembl.org/id/ENST00000678193.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504625.1", "url": "https://www.ensembl.org/id/ENSP00000504625.1" } ] } }, { "isoform_ac": "A0A7I2V5V0-1", "url": "", "sequence": { "sequence": "MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRSVSDVFDFFACSRGVFWGCSEGIGEPPAGLE", "length": 83, "header": "tr|A0A7I2V5V0-1|PPIH_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "locus": { "chromosome": "1", "start_pos": 42659345, "end_pos": 42658447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000677307.1", "url": "https://www.ensembl.org/id/ENST00000677307.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504781.1", "url": "https://www.ensembl.org/id/ENSP00000504781.1" } ] } }, { "isoform_ac": "A0A7I2YQS4-1", "url": "", "sequence": { "sequence": "XQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM", "length": 134, "header": "tr|A0A7I2YQS4-1|A0A7I2YQS4_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "locus": { "chromosome": "1", "start_pos": 42667418, "end_pos": 42659228, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000677312.1", "url": "https://www.ensembl.org/id/ENST00000677312.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504195.1", "url": "https://www.ensembl.org/id/ENSP00000504195.1" } ] } }, { "isoform_ac": "C9JQD4-1", "url": "", "sequence": { "sequence": "MKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM", "length": 151, "header": "tr|C9JQD4-1|PPIH_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=2 CANONICAL=O43447-1" }, "locus": { "chromosome": "1", "start_pos": 42667416, "end_pos": 42658856, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000678308.1", "url": "https://www.ensembl.org/id/ENST00000678308.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000503998.1", "url": "https://www.ensembl.org/id/ENSP00000503998.1" } ] } }, { "isoform_ac": "H0YEL5-1", "url": "", "sequence": { "sequence": "GDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM", "length": 96, "header": "tr|H0YEL5-1|H0YEL5_HUMAN Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "locus": { "chromosome": "1", "start_pos": 42667416, "end_pos": 42664863, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000461351.1", "url": "https://www.ensembl.org/id/ENST00000461351.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000436091.1", "url": "https://www.ensembl.org/id/ENSP00000436091.1" } ] } }, { "isoform_ac": "O43447-1", "url": "", "sequence": { "sequence": "MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM", "length": 177, "header": "sp|O43447-1|PPIH_HUMAN Isoform 1 of Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "locus": { "chromosome": "1", "start_pos": 42667416, "end_pos": 42658447, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000677900.1", "url": "https://www.ensembl.org/id/ENST00000677900.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504595.1", "url": "https://www.ensembl.org/id/ENSP00000504595.1" } ] } }, { "isoform_ac": "O43447-2", "url": "", "sequence": { "sequence": "MIAGDSDRRKDGVPIGYKGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM", "length": 134, "header": "sp|O43447-2|PPIH_HUMAN Isoform 2 of Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens OX=9606 GN=PPIH PE=1 SV=1 CANONICAL=O43447-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O43447", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43447" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" }, { "id": "28510447", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28510447" }, { "id": "22121020", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/22121020" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin.", "journal": "J. Biol. Chem.", "date": "2000", "authors": "Reidt U, Reuter K, Achsel T, Ingelfinger D, Luhrmann R, Ficner R", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "reference": [ { "type": "PubMed", "id": "10713041", "url": "https://glygen.org/publication/PubMed/10713041" } ] }, { "title": "Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.", "journal": "Molecular cell", "date": "2000", "authors": "Das R, Zhou Z, Reed R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "10882114", "url": "https://glygen.org/publication/PubMed/10882114" } ] }, { "title": "The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans.", "journal": "Nature", "date": "2000", "authors": "Zhou Z, Luo MJ, Straesser K, Katahira J, Hurt E, Reed R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "11014198", "url": "https://glygen.org/publication/PubMed/11014198" } ] }, { "title": "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.", "journal": "The EMBO journal", "date": "2000", "authors": "Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "11101529", "url": "https://glygen.org/publication/PubMed/11101529" } ] }, { "title": "The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site.", "journal": "RNA (New York, N.Y.)", "date": "2001", "authors": "Ismaili N, Sha M, Gustafson EH, Konarska MM", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "11233976", "url": "https://glygen.org/publication/PubMed/11233976" } ] }, { "title": "A cyclophilin functions in pre-mRNA splicing.", "journal": "The EMBO journal", "date": "2002", "authors": "Horowitz DS, Lee EJ, Mabon SA, Misteli T", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "reference": [ { "type": "PubMed", "id": "11823439", "url": "https://glygen.org/publication/PubMed/11823439" } ] }, { "title": "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.", "journal": "RNA (New York, N.Y.)", "date": "2002", "authors": "Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "11991638", "url": "https://glygen.org/publication/PubMed/11991638" } ] }, { "title": "Large-scale proteomic analysis of the human spliceosome.", "journal": "Genome research", "date": "2002", "authors": "Rappsilber J, Ryder U, Lamond AI, Mann M", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "12176931", "url": "https://glygen.org/publication/PubMed/12176931" } ] }, { "title": "Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.", "journal": "Science (New York, N.Y.)", "date": "2002", "authors": "Makarov EM, Makarova OV, Urlaub H, Gentzel M, Will CL, Wilm M, Luhrmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "12411573", "url": "https://glygen.org/publication/PubMed/12411573" } ] }, { "title": "5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly.", "journal": "Genes & development", "date": "2002", "authors": "Reichert VL, Le Hir H, Jurica MS, Moore MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "12414731", "url": "https://glygen.org/publication/PubMed/12414731" } ] }, { "title": "Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Hartmuth K, Urlaub H, Vornlocher HP, Will CL, Gentzel M, Wilm M, Luhrmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "12477934", "url": "https://glygen.org/publication/PubMed/12477934" } ] }, { "title": "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide.", "journal": "Journal of molecular biology", "date": "2003", "authors": "Reidt U, Wahl MC, Fasshauer D, Horowitz DS, Luhrmann R, Ficner R", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" }, { "database": "RefSeq", "id": "NP_001317439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439" } ], "reference": [ { "type": "PubMed", "id": "12875835", "url": "https://glygen.org/publication/PubMed/12875835" } ] }, { "title": "A simple whole cell lysate system for in vitro splicing reveals a stepwise assembly of the exon-exon junction complex.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Kataoka N, Dreyfuss G", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "14625303", "url": "https://glygen.org/publication/PubMed/14625303" } ] }, { "title": "Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.", "journal": "The EMBO journal", "date": "2004", "authors": "Xu YZ, Newnham CM, Kameoka S, Huang T, Konarska MM, Query CC", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "14713954", "url": "https://glygen.org/publication/PubMed/14713954" } ] }, { "title": "The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.", "journal": "Nature immunology", "date": "2004", "authors": "Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T", "evidence": [ { "database": "Reactome", "id": "R-HSA-9692916", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9692916" } ], "reference": [ { "type": "PubMed", "id": "15208624", "url": "https://glygen.org/publication/PubMed/15208624" } ] }, { "title": "Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.", "journal": "RNA (New York, N.Y.)", "date": "2005", "authors": "Tange TO, Shibuya T, Jurica MS, Moore MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "16314458", "url": "https://glygen.org/publication/PubMed/16314458" } ] }, { "title": "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.", "journal": "RNA", "date": "2006", "authors": "Liu S, Rauhut R, Vornlocher HP, Luhrmann R", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "reference": [ { "type": "PubMed", "id": "16723661", "url": "https://glygen.org/publication/PubMed/16723661" } ] }, { "title": "Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.", "journal": "Molecular and cellular biology", "date": "2006", "authors": "Deckert J, Hartmuth K, Boehringer D, Behzadnia N, Will CL, Kastner B, Stark H, Urlaub H, Luhrmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "16809785", "url": "https://glygen.org/publication/PubMed/16809785" } ] }, { "title": "Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation.", "journal": "Journal of virology", "date": "2007", "authors": "Law AH, Lee DC, Cheung BK, Yim HC, Lau AS", "evidence": [ { "database": "Reactome", "id": "R-HSA-9692916", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9692916" } ], 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"17270291", "url": "https://glygen.org/publication/PubMed/17270291" } ] }, { "title": "Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.", "journal": "The EMBO journal", "date": "2007", "authors": "Behzadnia N, Golas MM, Hartmuth K, Sander B, Kastner B, Deckert J, Dube P, Will CL, Urlaub H, Stark H, Luhrmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "17332742", "url": "https://glygen.org/publication/PubMed/17332742" } ] }, { "title": "The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages.", "journal": "Immunobiology", "date": "2007", "authors": "Leth-Larsen R, Zhong F, Chow VT, Holmskov U, Lu J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9692916", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9692916" } ], 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General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43447", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43447" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] }, { "title": "Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors.", "journal": "Nature communications", "date": "2021", "authors": "Cretu C, Gee P, Liu X, Agrawal A, Nguyen TV, Ghosh AK, Cook A, Jurica M, Larsen NA, Pena V", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "34301950", "url": "https://glygen.org/publication/PubMed/34301950" } ] }, { "title": "Structural basis of branch site recognition by the human spliceosome.", "journal": "Science (New York, N.Y.)", "date": "2022", "authors": "Tholen J, Razew M, Weis F, Galej WP", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "34822310", "url": "https://glygen.org/publication/PubMed/34822310" } ] }, { "title": "Retinitis pigmentosa-linked mutation in DHX38 modulates its splicing activity.", "journal": "PloS one", "date": "2022", "authors": "Obuca M, Cvackova Z, Kubovciak J, Kolar M, Stanek D", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "35385551", "url": "https://glygen.org/publication/PubMed/35385551" } ] }, { "title": "A compensatory base change in U1 snRNA suppresses a 5' splice site mutation.", "journal": "Cell", "date": "1986", "authors": "Zhuang Y, Weiner AM", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "3757028", "url": "https://glygen.org/publication/PubMed/3757028" } ] }, { "title": "PPIH gene regulation system and its prognostic significance in hepatocellular carcinoma: a comprehensive analysis.", "journal": "Aging", "date": "2023-10-23", "authors": "Ye Jun, Pang Yilin, Yang Xunjun, Zhang Chuan, Shi Lei, Chen Zhitao, Huang Guijia, Wang Xianhe, Lu Fangyang", "evidence": [ { "database": "RefSeq", "id": "NP_001317439", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439" } ], "reference": [ { "type": "PubMed", "id": "37874737", "url": "https://glygen.org/publication/PubMed/37874737" } ] }, { "title": "Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A.", "journal": "Genes & development", "date": "1996", "authors": "Gozani O, Feld R, Reed R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "8566756", "url": "https://glygen.org/publication/PubMed/8566756" } ] }, { "title": "A human RNA helicase-like protein, HRH1, facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome.", "journal": "Genes & development", "date": "1996", "authors": "Ohno M, Shimura Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "8608946", "url": "https://glygen.org/publication/PubMed/8608946" } ] }, { "title": "Association of U2 snRNP with the spliceosomal complex E.", "journal": "Nucleic acids research", "date": "1997", "authors": "Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "9016565", "url": "https://glygen.org/publication/PubMed/9016565" } ] }, { "title": "U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction.", "journal": "Genes & development", "date": "1997", "authors": "Fleckner J, Zhang M, Valcarcel J, Green MR", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "9242493", "url": "https://glygen.org/publication/PubMed/9242493" } ] }, { "title": "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs.", "journal": "RNA", "date": "1997", "authors": "Horowitz DS, Kobayashi R, Krainer AR", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "reference": [ { "type": "PubMed", "id": "9404889", "url": "https://glygen.org/publication/PubMed/9404889" } ] }, { "title": "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition.", "journal": "Genes & development", "date": "1998", "authors": "Berglund JA, Abovich N, Rosbash M", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "9512519", "url": "https://glygen.org/publication/PubMed/9512519" } ] }, { "title": "Human homologs of yeast prp16 and prp17 reveal conservation of the mechanism for catalytic step II of pre-mRNA splicing.", "journal": "The EMBO journal", "date": "1998", "authors": "Zhou Z, Reed R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "9524131", "url": "https://glygen.org/publication/PubMed/9524131" } ] }, { "title": "The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplices in vitro.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1998", "authors": "Laggerbauer B, Achsel T, Luhrmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "9539711", "url": "https://glygen.org/publication/PubMed/9539711" } ] }, { "title": "The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins.", "journal": "RNA (New York, N.Y.)", "date": "1998", "authors": "Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "reference": [ { "type": "PubMed", "id": "9570313", "url": "https://glygen.org/publication/PubMed/9570313" } ] }, { "title": "A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site.", "journal": "Molecular and cellular biology", "date": "1998", "authors": "Gozani O, Potashkin J, Reed R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "9671485", "url": "https://glygen.org/publication/PubMed/9671485" } ] }, { "title": "The mammalian homologue of Prp16p is overexpressed in a cell line tolerant to Leflunomide, a new immunoregulatory drug effective against rheumatoid arthritis.", "journal": "RNA (New York, N.Y.)", "date": "1998", "authors": "Ortlepp D, Laggerbauer B, Mullner S, Achsel T, Kirschbaum B, Luhrmann R", "evidence": [ { "database": "Reactome", "id": "R-HSA-72163", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-72163" } ], "reference": [ { "type": "PubMed", "id": "9701291", "url": "https://glygen.org/publication/PubMed/9701291" } ] }, { "title": 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"database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "pmid": "" }, { "name": "spliceosomal complex", "id": "GO:0005681", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005681", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "pmid": "" }, { "name": "U4/U6 snRNP", "id": "GO:0071001", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071001", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "pmid": "" }, { "name": "U4/U6 x U5 tri-snRNP complex", "id": "GO:0046540", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046540", "evidence": [ { "database": "UniProtKB", "id": "O43447", "url": "https://www.uniprot.org/uniprot/O43447" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 5, "end_pos": 7, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16237", "name": "", "equation": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "A0A8I6GKI8-1", "P24368-1", "Q9QVC8-1", "P97534-1", "Q3B7U9-1", "Q66H94-1", "Q62658-1", "Q812D3-1", "O55035-1", "Q6DGG0-1", "P10111-1", "P29117-1", "Q5U2V1-1", "A0A8I6GGK9-1", "A0A8I6AE14-1", "G3V7V5-1", "G3V6L9-1", "A0A8I6GH88-1", "A0A8I6A7U0-1", "D4AEG3-1", "A0A0G2K869-1", "M0RCZ9-1", "Q4KLI4-1", "A0A8I5ZMT9-1", "Q6AYQ9-1", "A0A8I5ZR77-1", "A0A8I5ZPZ9-1", "A0A8I6A7W4-1", "A0A8I6A3L4-1", "A0A8I6GJ67-1", "A0A8I6AK73-1", "A0A8I6GE67-1", "A0A8I6GB94-1", "A0A8I6AFJ6-1", "D3ZQF4-1", "A0A8I5ZVA3-1", "A0A8I6A629-1", "A0A8I6AP42-1", "A0A8I5Y1J2-1", "F7EYK0-1", "A0A8I6AIC0-1", "A0A8I6ADW5-1", "A6K0V4-1", "Q14318-1", "Q5VVH2-1", "O75344-1", "O00170-1", "Q96AY3-1", "O95302-1", "P0DN26-1", "P68106-1", "Q02790-1", "Q15257-1", "Q9NYL4-1", "Q9NWM8-1", "P62942-1", 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"Q54G21-1", "Q54N80-1", "Q54NB6-1", "Q54SR7-1", "Q54WH6-1", "Q54Y27-1", "Q55CJ3-1", "Q86J17-1", "Q55EZ0-1", "B0G119-1", "Q54QI6-1", "Q54UR2-1", "Q9UA41-1", "Q54SM3-1", "Q9NI62-1", "Q9TW32-1", "P25007-1", "Q9V3G3-1", "P15425-1", "P54353-1", "P54397-1", "P48375-1", "Q9VL78-1", "A0A0B4K7C5-1", "Q4V5H1-1", "Q9VQQ0-1", "Q7K2I4-1", "Q8MKJ6-1", "Q9VNG7-1", "Q9VXN8-1", "Q9VGK3-1", "Q9VBU4-1", "Q9XYZ6-1", "Q9W227-1", "Q9W0Q2-1", "Q7K3D4-1", "Q8IRJ5-1" ], "evidence": [ { "id": "16237", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16237" } ] }, { "id": "R-HSA-9728804", "name": "SARS-CoV-1 nsp1 binds to PPIase", "equation": "", "summary": "Peptidyl-prolyl isomerases (PPIase) function as protein folding chaperones. All five PPIases PPIA, PPIB, PPIG, PPIH, and FKBP1A have been shown to bind to SARS-CoV-1 nonstructural protein 1 (nsp1), significantly activating the Cyclophilin A/NFAT pathway, ultimately enhancing the induction of the IL-2 promoter. The increase of NFAT activation extends to all three major NFAT species, suggesting a potential for induction of broad and systemic cytokine dysregulation by affecting several types of immune cells (Pfefferle et al, 2011; Law et al, 2007).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62937-1", "P62942-1", "Q13427-1", "P23284-1", "O43447-1" ], "evidence": [ { "id": "R-HSA-9728804", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9728804" } ] }, { "id": "R-HSA-9770132", "name": "Formation of the Spliceosomal Pre-B complex", "equation": "", "summary": "The U4/U6.U5 tri-snRNP complex loosely binds the Spliceosomal A complex to form the Spliceosomal Pre-B complex (Boesler et al. 2016). The U4/U6.U5 tri-snRNP comprises the U4 snRNA base-paired with the U6 snRNA within U4/U6 di-snRNP, the U5 snRNP and tri-snRNP specific factors. The 3' end of the U2 snRNA is bound to the branch point sequence which leaves the 5' end of the U2 snRNA free to base-pair with the 3' end of the U6 from the tri-snRNP (Hausner et al. 1990, Boesler et al. 2016). In addition, the SF3A1 component of the U2 snRNP binds the U4/U6 region of tri-snRNP (Charenton et al. 2019). U1 snRNP, bound to the 5\u2019splice site transiently interacts with tri-snRNP proximal to the DDX23 helicase and U6 and U5 acceptor sequences. The PRPF4B kinase involved B complex formation via phosphorylation of tri-snRNP components, is loosely bound to the pre-B complex. The components of the Spliceosomal Pre-B complex have been ascertained using proteomic and structural methods (Boesler et al. 2016, Zhan et al. 2018, Charenton et al. 2019)..", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-156649", "R-HSA-77506", "R-HSA-156781", "R-HSA-6791189", "R-HSA-8849139", "R-HSA-9769525", "R-HSA-9770239", "R-HSA-9770259" ], "output_participant_list": [ "R-HSA-53703", "R-HSA-72043", "R-HSA-72048", "R-HSA-9770246" ], "enzyme_list": [ "O75643-1", "Q86XP3-1", "Q53GS9-1", "Q08211-1", "P24928-1", "Q13523-1", "Q13838-1", "Q7L014-1", "P30876-1", "Q9BUQ8-1", "P42285-1", "P17844-1", "O43143-1", "O43447-1" ], "evidence": [ { "id": "R-HSA-9770132", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770132" } ] }, { "id": "R-HSA-9770142", "name": "Formation of the Spliceosomal B complex", "equation": "", "summary": "The DDX23 RNA helicase (homolog of yeast Prp28) binds ATP to dissociate the 5' splice site of the pre-mRNA from the U1 snRNA, causing displacement of the U1 snRNP from the spliceosome and allowing the 5' splice site to anneal with the U6 snRNA and the 5' exon with the U5 snRNA (Ismaili et al. 2001, Mohlmann et al. 2014, Boesler et al. 2016, Charenton et al. 2019). As annealing between the U6 snRNA and the 5' splice site proceeds, the U4 snRNA previously base-paired with the U6 snRNA becomes available to accommodate SNRNP200 (homolog of yeast Brr2) at the position where it will later dissociate the U4-U6 RNA duplex during subsequent activation. The B complex assembly is further stabilized by the recruitment of several B-specific proteins such as MFAP1, PRP38A, ZMAT2, and WBP4 (FBP21) whose roles have still to be precisely defined. The components of the Spliceosomal B complex have been ascertained using proteomic and structural methods (Rappsilber et al. 2002, Deckert et al. 2006, Bessonov et al. 2008, Wolf et al. 2009, Bessonov et al. 2010, Schmidt et al. 2014, Boesler et al. 2015, Zhang et al. 2018, Charenton et al. 2019, Kastner et al. 2019).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-8867895", "R-HSA-8867897", "R-HSA-8867887", "R-HSA-8867889", "R-HSA-9770248", "R-HSA-9770255" ], "output_participant_list": [ "R-HSA-4615999", "R-HSA-6806778", "R-HSA-6806793", "R-HSA-71917", "R-HSA-71879", "R-HSA-72049", "R-HSA-8867890", "R-HSA-9769526", "R-HSA-9770250", "R-HSA-9770254" ], "enzyme_list": [ "O75643-1", "Q86XP3-1", "Q53GS9-1", "Q08211-1", "P24928-1", "Q13523-1", "Q13838-1", "Q7L014-1", "P30876-1", "Q9BUQ8-1", "P42285-1", "P17844-1", "O43143-1", "O43447-1" ], "evidence": [ { "id": "R-HSA-9770142", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770142" } ] }, { "id": "R-HSA-9770145", "name": "Formation of the Spliceosomal Bact complex", "equation": "", "summary": "Activation of the Spliceosomal B complex to form the Spliceosomal Bact complex is believed to occur in several complex steps. SNRNP200 (homolog of yeast Brr2) of the U5 snRNP uses ATP to dissociate the U4 snRNP from the spliceosome. This renders U6 snRNA free to form additional interactions with U2 snRNA and fold its internal stem loop to create the active site (Laggerbauer et al. 1998, Lamond et al. 1988, Bessonov et al. 2010, Agafonov et al. 2011, Fica et al. 2013, Galej et al. 2016, Haselbach et al. 2018, Zhang et al. 2018, Kastner et al. 2019). In this active site four phosphate groups of the U6 snRNA cooridinate the two magnesium ions that catalyze both transesterification reactions of pre-mRNA splicing..The PRP19-CDC5L complex (Ajuh et al. 2000, also called the NTC complex) and the PRP19-CDC5L related complex (also called the NTR complex) are recruited during this transition and stabilize the active site (Bessonov et al. 2010, Agafonov et al. 2011, Haselbach et al. 2018, Zhang et al. 2018, Kastner et al. 2019). Splicing does not yet occur because the SF3B1 subunit of the U2 snRNP blocks the branch point and SF3A2 and RNF113A protect the 5' splice site, preventing the intron branch point from reacting with the 5' splice site (Gozani et al. 1996, Gozani et al. 1998, Haselbach et al. 2018, Zhang et al. 2018, Tholen et al. 2022). SNRNP200 and the RES complex retain the SF3B subcomplex in the spliceosome (Haselbach et al. 2018, Zhang et al. 2018). CWC22 recruits EIF4A3, which will form the exon junction complex (EJC) (Busetto et al. 2020) . The components of the Spliceosomal Bact complex have been ascertained using proteomic and structural methods (Bessonov et al. 2010, Agafonov et al. 2011, Haselbach et al. 2018, Zhang et al. 2018, Kastner et al. 2019, Townsend et al. 2020).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-HSA-8849149", "R-HSA-8850837", "R-HSA-8850839", "R-HSA-8865956", "R-HSA-8867885", "R-HSA-8867892", "R-HSA-8952110", "R-HSA-9769561", "R-HSA-9769562", "R-HSA-9769563" ], "output_participant_list": [ "R-HSA-3246027", "R-HSA-53517", "R-HSA-71875", "R-HSA-71881" ], "enzyme_list": [ "O75643-1", "Q86XP3-1", "Q13356-1", "Q9H2H8-1", "O15541-1", "P11142-1", "Q08211-1", "P24928-1", "O60306-1", "Q9UNP9-1", "P38919-1", "Q13838-1", "Q9Y3C6-1", "Q7L014-1", "P30876-1", "O60231-1", "Q9BUQ8-1", "P42285-1", "P17844-1", "O43143-1", "Q9UMS4-1", "O43447-1" ], "evidence": [ { "id": "R-HSA-9770145", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9770145" } ] } ], "reaction_participants": [ { "participant_id": "R-HSA-156649", "participant_name": "ALYREF [nucleoplasm]", "crossref": [ { "id": "Q86V81", "database": "UniProt", "url": "" }, { "id": "3ULH", "database": "PDB", "url": "" }, { "id": "Q86V81", "database": "PRO", "url": "" }, { "id": "Q86V81", "database": "GeneCards", "url": "" }, { "id": "7ZNK", "database": "PDB", "url": "" }, { "id": "ENSG00000183684", "database": "OpenTargets", "url": "" }, { "id": "NP_005773.3", "database": "RefSeq", "url": "" }, { "id": "Q86V81", "database": "Pharos - Targets", "url": "" }, { "id": "7ZNJ", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-156781", "participant_name": "SRRM1 [nucleoplasm]", "crossref": [ { "id": "Q8IYB3", "database": "UniProt", "url": "" }, { "id": "1MP1", "database": "PDB", "url": "" }, { "id": "ENSG00000133226", "database": "Ensembl", "url": "" }, { "id": "ENSP00000326261", "database": "Ensembl", "url": "" }, { "id": "ENST00000323848", "database": "Ensembl", "url": "" }, { "id": "7ABG", "database": "PDB", "url": "" }, { "id": "ENSG00000133226", "database": "OpenTargets", "url": "" }, { "id": "NP_005830.2", "database": "RefSeq", "url": "" }, { "id": "7ABH", "database": "PDB", "url": "" }, { "id": "Q8IYB3", "database": "PRO", "url": "" }, { "id": "NP_001290378.1", "database": "RefSeq", "url": "" }, { "id": "Q8IYB3", "database": "GeneCards", "url": "" }, { "id": "7DVQ", "database": "PDB", "url": "" }, { "id": "ENSG00000133226-SRRM1", "database": "HPA", "url": "" }, { "id": "NP_001290377.1", "database": "RefSeq", "url": "" }, { "id": "6FF4", "database": "PDB", "url": "" }, { "id": "Q8IYB3", "database": "Pharos - Targets", "url": "" }, { "id": "6FF7", "database": "PDB", "url": "" }, { "id": "7ABI", "database": "PDB", "url": "" } ] }, { "participant_id": "R-HSA-3246027", "participant_name": "TCERG1 [nucleoplasm]", "crossref": [ { "id": "2N4T", "database": "PDB", "url": "" }, { "id": "2N4W", "database": "PDB", "url": "" }, { "id": "O14776", "database": "PRO", 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"url": "" }, { "id": "Q08211", "database": "GeneCards", "url": "" }, { "id": "ENSG00000135829-DHX9", "database": "HPA", "url": "" }, { "id": "HMDBP11707", "database": "HMDB Protein", "url": "" }, { "id": "ENSG00000135829", "database": "OpenTargets", "url": "" }, { "id": "3VYX", "database": "PDB", "url": "" }, { "id": "Q08211", "database": "UniProt", "url": "" }, { "id": "ENSP00000356520", "database": "Ensembl", "url": "" }, { "id": "Q08211", "database": "PRO", "url": "" }, { "id": "Q08211", "database": "Pharos - Targets", "url": "" }, { "id": "NP_001348.2", "database": "RefSeq", "url": "" }, { "id": "3VYY", "database": "PDB", "url": "" }, { "id": "3LLM", "database": "PDB", "url": "" }, { "id": "ENSG00000135829", "database": "Ensembl", "url": "" } ] }, { "participant_id": "R-HSA-53703", "participant_name": "DNAJC8 [nucleoplasm]", "crossref": [ { "id": "7VPX", "database": "PDB", "url": "" }, { "id": "O75937", "database": "Pharos - Targets", "url": "" }, { "id": "O75937", "database": 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"activity": "", "evidence": [ { "id": "A0A8I6ADW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6ADW5" } ] } ] }, { "uniprot_ac": "A0A8I6AE14", "gene_name": "Fkbp7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AE14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AE14" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AE14", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AE14" } ] } ] }, { "uniprot_ac": "A0A8I6AFJ6", "gene_name": "ENSRNOG00000068575", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AFJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFJ6" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AFJ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AFJ6" } ] } ] }, { "uniprot_ac": "A0A8I6AIC0", "gene_name": "ENSRNOG00000066761", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AIC0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AIC0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AIC0" } ] } ] }, { "uniprot_ac": "A0A8I6AK73", "gene_name": "ENSRNOG00000065084", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AK73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK73" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AK73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AK73" } ] } ] }, { "uniprot_ac": "A0A8I6AP42", "gene_name": "Ppia-ps13", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6AP42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AP42" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6AP42", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AP42" } ] } ] }, { "uniprot_ac": "A0A8I6GB94", "gene_name": "Nktr", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GB94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GB94" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GB94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GB94" } ] } ] }, { "uniprot_ac": "A0A8I6GE67", "gene_name": "ENSRNOG00000063066", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GE67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GE67" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GE67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GE67" } ] } ] }, { "uniprot_ac": "A0A8I6GGK9", "gene_name": "Ppie", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GGK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GGK9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GGK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GGK9" } ] } ] }, { "uniprot_ac": "A0A8I6GH88", "gene_name": "Fkbp2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GH88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GH88" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GH88", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GH88" } ] } ] }, { "uniprot_ac": "A0A8I6GJ67", "gene_name": "Pin1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ67" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GJ67", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GJ67" } ] } ] }, { "uniprot_ac": "A0A8I6GKI8", "gene_name": "Pin4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A0A8I6GKI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GKI8" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A0A8I6GKI8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GKI8" } ] } ] }, { "uniprot_ac": "A2AR02", "gene_name": "Ppig", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A2AR02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AR02" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A2AR02", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A2AR02" } ] } ] }, { "uniprot_ac": "A6K0V4", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "A6K0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6K0V4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "A6K0V4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6K0V4" } ] } ] }, { "uniprot_ac": "B0G119", "gene_name": "", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "B0G119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G119" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "B0G119", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B0G119" } ] } ] }, { "uniprot_ac": "D3ZQF4", "gene_name": "Fkbp6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "D3ZQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "D3ZQF4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZQF4" } ] } ] }, { "uniprot_ac": "D4AEG3", "gene_name": "Ppil4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "D4AEG3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4AEG3" } ] } ] }, { "uniprot_ac": "F5H284", "gene_name": "PPIAL4D", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F5H284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F5H284" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F5H284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F5H284" } ] } ] }, { "uniprot_ac": "F7EYK0", "gene_name": "Fkbp5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "F7EYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EYK0" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "F7EYK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F7EYK0" } ] } ] }, { "uniprot_ac": "G3V6L9", "gene_name": "Fkbp3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3V6L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6L9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3V6L9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6L9" } ] } ] }, { "uniprot_ac": "G3V7V5", "gene_name": "Fkbp11", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "G3V7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7V5" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "G3V7V5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V7V5" } ] } ] }, { "uniprot_ac": "M0RCZ9", "gene_name": "Ppial4g", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCZ9" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "M0RCZ9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RCZ9" } ] } ] }, { "uniprot_ac": "O00170", "gene_name": "AIP", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O00170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00170" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O00170", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00170" } ] } ] }, { "uniprot_ac": "O15541", "gene_name": "RNF113A", "activity": [ { "ec_number": "2.3.2.27", "activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.", "evidence": [ { "id": "O15541", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15541" } ] }, { "ec_number": "2.3.2.27", "activity": "", "evidence": [ { "id": "O15541", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15541" } ] } ] }, { "uniprot_ac": "O35465", "gene_name": "Fkbp8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35465" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O35465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35465" } ] } ] }, { "uniprot_ac": "O43143", "gene_name": "DHX15", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O43143", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43143" } ] } ] }, { "uniprot_ac": "O43447", "gene_name": "PPIH", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O43447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43447" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O43447", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43447" } ] } ] }, { "uniprot_ac": "O54998", "gene_name": "Fkbp7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O54998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54998" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O54998", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54998" } ] } ] }, { "uniprot_ac": "O55035", "gene_name": "Ppig", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O55035", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O55035" } ] } ] }, { "uniprot_ac": "O60231", "gene_name": "DHX16", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60231", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60231" } ] } ] }, { "uniprot_ac": "O60306", "gene_name": "AQR", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O60306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60306" } ] } ] }, { "uniprot_ac": "O75344", "gene_name": "FKBP6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O75344", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75344" } ] } ] }, { "uniprot_ac": "O75643", "gene_name": "SNRNP200", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "O75643", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75643" } ] } ] }, { "uniprot_ac": "O95302", "gene_name": "FKBP9", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "O95302", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95302" } ] } ] }, { "uniprot_ac": "P0DN26", "gene_name": "PPIAL4F", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN26", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN26" } ] } ] }, { "uniprot_ac": "P0DN37", "gene_name": "PPIAL4G", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P0DN37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0DN37" } ] } ] }, { "uniprot_ac": "P10111", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P10111", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10111" } ] } ] }, { "uniprot_ac": "P11142", "gene_name": "HSPA8", "activity": [ { "ec_number": "3.6.4.10", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] }, { "ec_number": "3.6.4.10", "activity": "", "evidence": [ { "id": "P11142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11142" } ] } ] }, { "uniprot_ac": "P14832", "gene_name": "CPR1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14832" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P14832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14832" } ] } ] }, { "uniprot_ac": "P15425", "gene_name": "ninaA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P15425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15425" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P15425", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15425" } ] } ] }, { "uniprot_ac": "P17742", "gene_name": "Ppia", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P17742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17742" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P17742", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17742" } ] } ] }, { "uniprot_ac": "P17844", "gene_name": "DDX5", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P17844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17844" } ] } ] }, { "uniprot_ac": "P20081", "gene_name": "FPR1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P20081", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20081" } ] } ] }, { "uniprot_ac": "P22696", "gene_name": "ESS1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P22696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22696" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P22696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22696" } ] } ] }, { "uniprot_ac": "P23284", "gene_name": "PPIB", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P23284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23284" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P23284", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23284" } ] } ] }, { "uniprot_ac": "P23285", "gene_name": "CPR2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P23285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23285" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P23285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23285" } ] } ] }, { "uniprot_ac": "P24368", "gene_name": "Ppib", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P24368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24368" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P24368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24368" } ] } ] }, { "uniprot_ac": "P24369", "gene_name": "Ppib", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P24369", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24369" } ] } ] }, { "uniprot_ac": "P24928", "gene_name": "POLR2A", "activity": [ { "ec_number": "2.7.7.6", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "P24928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24928" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "P24928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24928" } ] }, { "ec_number": "2.7.7.48", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "P24928", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24928" } ] } ] }, { "uniprot_ac": "P25007", "gene_name": "Cyp1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25007", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25007" } ] } ] }, { "uniprot_ac": "P25334", "gene_name": "CPR4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25334" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25334", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25334" } ] } ] }, { "uniprot_ac": "P25719", "gene_name": "CPR3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P25719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25719" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P25719", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25719" } ] } ] }, { "uniprot_ac": "P26883", "gene_name": "Fkbp1a", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26883" } ] } ] }, { "uniprot_ac": "P26885", "gene_name": "FKBP2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P26885", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26885" } ] } ] }, { "uniprot_ac": "P29117", "gene_name": "Ppif", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P29117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29117" } ] } ] }, { "uniprot_ac": "P30405", "gene_name": "PPIF", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30405" } ] } ] }, { "uniprot_ac": "P30412", "gene_name": "Ppic", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30412" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30412" } ] } ] }, { "uniprot_ac": "P30414", "gene_name": "NKTR", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30414" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30414", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30414" } ] } ] }, { "uniprot_ac": "P30415", "gene_name": "Nktr", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30415" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30415", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30415" } ] } ] }, { "uniprot_ac": "P30416", "gene_name": "Fkbp4", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P30416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30416" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P30416", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30416" } ] } ] }, { "uniprot_ac": "P30876", "gene_name": "POLR2B", "activity": [ { "ec_number": "2.7.7.6", "activity": "a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1).", "evidence": [ { "id": "P30876", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30876" } ] }, { "ec_number": "2.7.7.6", "activity": "", "evidence": [ { "id": "P30876", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30876" } ] } ] }, { "uniprot_ac": "P32472", "gene_name": "FPR2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P32472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32472" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P32472", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32472" } ] } ] }, { "uniprot_ac": "P35176", "gene_name": "CPR5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P35176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35176" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P35176", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35176" } ] } ] }, { "uniprot_ac": "P38911", "gene_name": "FPR3", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P38911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38911" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P38911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38911" } ] } ] }, { "uniprot_ac": "P38919", "gene_name": "EIF4A3", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P38919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38919" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P38919", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38919" } ] } ] }, { "uniprot_ac": "P40454", "gene_name": "RRD1", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P40454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40454" } ] } ] }, { "uniprot_ac": "P42285", "gene_name": "MTREX", "activity": [ { "ec_number": "3.6.4.13", "activity": "ATP + H2O = ADP + H(+) + phosphate.", "evidence": [ { "id": "P42285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42285" } ] }, { "ec_number": "3.6.4.13", "activity": "", "evidence": [ { "id": "P42285", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42285" } ] } ] }, { "uniprot_ac": "P45877", "gene_name": "PPIC", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45877", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45877" } ] } ] }, { "uniprot_ac": "P45878", "gene_name": "Fkbp2", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P45878", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45878" } ] } ] }, { "uniprot_ac": "P47103", "gene_name": "CPR7", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P47103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47103" } ] } ] }, { "uniprot_ac": "P48375", "gene_name": "Fkbp12", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P48375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48375" } ] } ] }, { "uniprot_ac": "P53691", "gene_name": "CPR6", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53691", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53691" } ] } ] }, { "uniprot_ac": "P53728", "gene_name": "CPR8", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P53728", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53728" } ] } ] }, { "uniprot_ac": "P54353", "gene_name": "dod", 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[protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P58389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58389" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P58389", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58389" } ] } ] }, { "uniprot_ac": "P59024", "gene_name": "Fkbp14", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P59024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59024" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P59024", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P59024" } ] } ] }, { "uniprot_ac": "P62937", "gene_name": "PPIA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62937", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62937" } ] } ] }, { "uniprot_ac": "P62942", "gene_name": "FKBP1A", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "P62942", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62942" } ] } ] }, { "uniprot_ac": "P68106", "gene_name": "FKBP1B", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "P68106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P68106" } ] }, { "ec_number": "5.2.1.8", "activity": "", 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"url": "https://www.uniprot.org/uniprot/Q4KLI4" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q4KLI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KLI4" } ] } ] }, { "uniprot_ac": "Q4V5H1", "gene_name": "Dmel\\CG17266", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q4V5H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V5H1" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q4V5H1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V5H1" } ] } ] }, { "uniprot_ac": "Q53GS9", "gene_name": "USP39", "activity": [ { "ec_number": "3.4.19.12", "activity": "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).", "evidence": [ { 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"ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54E95", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54E95" } ] } ] }, { "uniprot_ac": "Q54G21", "gene_name": "fkbp5", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54G21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G21" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54G21", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G21" } ] } ] }, { "uniprot_ac": "Q54LG6", "gene_name": "flpA", "activity": [ { "ec_number": "5.2.1.8", "activity": "[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0).", "evidence": [ { "id": "Q54LG6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54LG6" } ] }, { "ec_number": "5.2.1.8", "activity": "", "evidence": [ { "id": "Q54LG6", "database": "UniProtKB", 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