{ "uniprot_canonical_ac": "O43379-1", "uniprot_ac": "O43379", "uniprot_id": "WDR62_HUMAN", "mass": { "chemical_mass": 165954.0, "monoisotopic_mass": 165954.0 }, "refseq": { "ac": "NP_001077430", "name": "WD repeat-containing protein 62 isoform 1", "summary": "This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" }, "gene_names": [ { "name": "WDR62", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43379", "id": "O43379" }, { "name": "C19orf14; MCPH2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430", "id": "NP_001077430" }, { "name": "C19orf14", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43379", "id": "O43379" }, { "name": "WDR62", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430", "id": "NP_001077430" } ], "protein_names": [ { "name": "WD repeat-containing protein 62", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43379" }, { "name": "WD repeat-containing protein 62 isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430", "id": "NP_001077430" }, { "name": "microcephaly, primary autosomal recessive 2; WD repeat-containing protein 62", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430", "id": "NP_001077430" } ], "function": [ { "annotation": "JNK and WDR62 may regulate the dynamic interplay between polysomes stress granule and processing bodies, thereby mediating mRNA fate after stress.", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" }, { "database": "PubMed", "id": "19910486", "url": "https://glygen.org/publication/PubMed/19910486" } ] }, { "annotation": "Neurological outcome in WDR62 primary microcephaly.", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" }, { "database": "PubMed", "id": "35726608", "url": "https://glygen.org/publication/PubMed/35726608" } ] }, { "annotation": "Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806).", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379#function" }, { "database": "PubMed", "id": "20890278", "url": "https://glygen.org/publication/PubMed/20890278" }, { "database": "PubMed", "id": "20729831", "url": "https://glygen.org/publication/PubMed/20729831" }, { "database": "PubMed", "id": "26297806", "url": "https://glygen.org/publication/PubMed/26297806" } ] }, { "annotation": "This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" } ] }, { "annotation": "WD repeat domain 62 (WDR62) promotes resistance of colorectal cancer to oxaliplatin through modulating mitogen-activated protein kinase (MAPK) signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" }, { "database": "PubMed", "id": "35758246", "url": "https://glygen.org/publication/PubMed/35758246" } ] }, { "annotation": "WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" }, { "database": "PubMed", "id": "35808830", "url": "https://glygen.org/publication/PubMed/35808830" } ] } ], "disease": [ { "disease_id": "DOID:0070293", "recommended_name": { "id": "DOID:0070293", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070293", "name": "primary autosomal recessive microcephaly 2 with or without cortical malformations", "description": "A primary autosomal recessive microcephaly that has_material_basis_in homozygous or compound heterozygous mutation in the WDR62 gene on chromosome 19q13." }, "synonyms": [ { "id": "DOID:0070293", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070293", "name": "MCPH2", "description": "" }, { "id": "MONDO:0011435", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011435", "name": "microcephaly 2, primary, autosomal recessive, with or without cortical malformations", "description": "" }, { "id": "MONDO:0011435", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011435", "name": "microcephaly 2, primary, autosomal recessive, with or without cortical malformations", "description": "" }, { "id": "MONDO:0011435", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011435", "name": "MCPH2", "description": "" }, { "id": "MIM:604317", "resource": "MIM", "url": "https://www.omim.org/entry/604317", "name": "Microcephaly 2, primary, autosomal recessive, with or without cortical malformations", "description": "Microcephaly 2, primary, autosomal recessive, with or without cortical malformations" } ], "evidence": [ { "id": "604317", "database": "MIM", "url": "https://www.omim.org/entry/604317" } ] } ], "snv": [ { "evidence": [ { "id": "rs1047753488", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1047753488" }, { "id": "rs1047753488", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1047753488#frequency_tab" }, { "id": "rs1047753488", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1047753488" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1006, "end_pos": 1006, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IHS->NHS).", "chr_id": "19", "chr_pos": "36101709", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1006", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs996336427", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs996336427" }, { "id": "rs996336427", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs996336427#frequency_tab" }, { "id": "rs996336427", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs996336427" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1104, "end_pos": 1104, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KAS->NAS).", "chr_id": "19", "chr_pos": "36102843", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K1104", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs200316266", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200316266" }, { "id": "rs200316266", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200316266" }, { "id": "rs200316266", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs200316266#frequency_tab" }, { "id": "rs200316266", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs200316266" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 110, "end_pos": 110, "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTA->NTS).", "chr_id": "19", "chr_pos": "36060026", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A110", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs200316266", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200316266" }, { "id": "rs200316266", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs200316266" }, { "id": "rs200316266", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs200316266#frequency_tab" }, { "id": "rs200316266", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs200316266" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 110, "end_pos": 110, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTA->NTT).", "chr_id": "19", "chr_pos": "36060026", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A110", "keywords": [ "ebi", "germline", "disease" ], "disease": [ { "disease_id": "DOID:0070293", "recommended_name": { "id": "DOID:0070293", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070293", "name": "primary autosomal recessive microcephaly 2 with or without cortical malformations", "description": "A primary autosomal recessive microcephaly that has_material_basis_in homozygous or compound heterozygous mutation in the WDR62 gene on chromosome 19q13." }, "synonyms": [ { "id": "DOID:0070293", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0070293", "name": "MCPH2", "description": "" }, { "id": "MONDO:0011435", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011435", "name": "microcephaly 2, primary, autosomal recessive, with or without cortical malformations", "description": "" }, { "id": "MONDO:0011435", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011435", "name": "microcephaly 2, primary, autosomal recessive, with or without cortical malformations", "description": "" }, { "id": "MONDO:0011435", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011435", "name": "MCPH2", "description": "" }, { "id": "MIM:604317", "resource": "MIM", "url": "https://www.omim.org/entry/604317", "name": "Microcephaly 2, primary, autosomal recessive, with or without cortical malformations", "description": "Microcephaly 2, primary, autosomal recessive, with or without cortical malformations" } ] } ] }, { "evidence": [ { "id": "rs376931622", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs376931622" }, { "id": "rs376931622", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs376931622" }, { "id": "rs376931622", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs376931622#frequency_tab" }, { "id": "rs376931622", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs376931622" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1146, "end_pos": 1146, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DRT->NRT).", "chr_id": "19", "chr_pos": "36103063", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D1146", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1443977030", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1443977030" }, { "id": "rs1443977030", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1443977030#frequency_tab" }, { "id": "rs1443977030", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1443977030" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1226, "end_pos": 1226, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SIS->NIS).", "chr_id": "19", "chr_pos": "36103520", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S1226", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1284750218", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1284750218" }, { "id": "rs1284750218", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1284750218" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 1293, "end_pos": 1293, "sequence_org": "R", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NLR->NLT).", "chr_id": "19", "chr_pos": "36103721", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R1293", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O43379", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43379" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 1371, "end_pos": 1371, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (TAS->NAS).", "chr_id": "19", "chr_pos": "36103955", "ref_nt": "C", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "T1371", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": 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"sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IHS->NHS).", "chr_id": "19", "chr_pos": "36104841", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I1457", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs751275678", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs751275678" }, { "id": "rs751275678", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs751275678" }, { "id": "rs751275678", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs751275678#frequency_tab" }, { "id": "rs751275678", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs751275678" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 14, "end_pos": 14, "sequence_org": "A", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDA->NDS).", "chr_id": "19", "chr_pos": "36055011", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A14", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs761010604", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761010604" }, { "id": "rs761010604", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs761010604" }, { "id": "rs761010604", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs761010604" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 170, "end_pos": 170, "sequence_org": "I", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (IVS->NVS).", "chr_id": "19", "chr_pos": "36066375", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I170", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1417963749", "database": "dbSNP", "url": 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254, "end_pos": 254, "sequence_org": "I", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNI->NNT).", "chr_id": "19", "chr_pos": "36067889", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "I254", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs755050401", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755050401" }, { "id": "rs755050401", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs755050401" }, { "id": "rs755050401", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs755050401" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 380, "end_pos": 380, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DHS->NHS).", "chr_id": "19", "chr_pos": "36073436", "ref_nt": "A", "alt_nt": "null", 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"url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs577248303", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs577248303" }, { "id": "rs577248303", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs577248303" }, { "id": "rs577248303", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs577248303" }, { "id": "rs577248303", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs577248303#frequency_tab" }, { "id": "rs577248303", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs577248303" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 791, "end_pos": 791, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O43379", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43379" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": 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results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "common_name": "Human" } ], "gene": [ { "name": "WDR62", "url": "https://www.uniprot.org/uniprot/O43379", "locus": { "chromosome": "19", "start_pos": 36105108, "end_pos": 36054649, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000075702", "url": "https://www.ensembl.org/id/ENSG00000075702" } ] } } ], "crossref": [ { "id": "ENSG00000075702", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000075702", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O43379", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O43379", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "WDR62", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=WDR62", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "284403", "url": "https://www.ncbi.nlm.nih.gov/gene/284403", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "24502", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=24502", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O43379", "url": "https://www.ebi.ac.uk/intact/interactors/id:O43379*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011044", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011044", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011047", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011047", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR024977", "url": "https://www.ebi.ac.uk/interpro/entry/IPR024977", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:284403", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:284403", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "604317", "url": "http://www.omim.org/entry/604317", "database": "MIM", "categories": [ "Other" ] }, { "id": "613583", "url": "http://www.omim.org/entry/613583", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O43379", "url": "https://www.nextprot.org/entry/NX_O43379", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O43379", "url": "https://oglcnac.org/atlas/detail/O43379", "database": "O-GlcNAc Atlas", "categories": [ "Glycoproteomics" ] }, { "id": "O43379", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43379", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "YHLMVSS", "url": "https://omabrowser.org/oma/group/YHLMVSS/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1220745at2759", "url": "http://www.orthodb.org/?query=1220745at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR44813", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44813", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR44813:SF1", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR44813:SF1", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45589", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45589", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45589:SF3", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45589:SF3", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF12894", "url": "http://pfam.xfam.org/family/PF12894", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O43379", "url": "https://pharos.nih.gov/targets/O43379", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O43379", "url": "http://purl.obolibrary.org/obo/PR_O43379", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A2R8YD43", "url": "https://www.uniprot.org/uniprot/A0A2R8YD43", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YD43-1", "url": 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"url": "https://www.uniprot.org/uniprot/A0A7P0T972", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T972-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T972-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T975", "url": "https://www.uniprot.org/uniprot/A0A7P0T975", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T975-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T975-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9D9", "url": "https://www.uniprot.org/uniprot/A0A7P0T9D9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9D9-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T9D9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9F6", "url": "https://www.uniprot.org/uniprot/A0A7P0T9F6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9F6-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T9F6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9G3", "url": "https://www.uniprot.org/uniprot/A0A7P0T9G3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9G3-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T9G3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9T4", "url": "https://www.uniprot.org/uniprot/A0A7P0T9T4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9T4-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T9T4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9T7", "url": "https://www.uniprot.org/uniprot/A0A7P0T9T7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0T9T7-1", "url": "https://www.uniprot.org/uniprot/A0A7P0T9T7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TA81", "url": "https://www.uniprot.org/uniprot/A0A7P0TA81", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TA81-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TA81-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TA99", "url": "https://www.uniprot.org/uniprot/A0A7P0TA99", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TA99-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TA99-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TAH3", "url": "https://www.uniprot.org/uniprot/A0A7P0TAH3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TAH3-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TAH3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TAK3", "url": "https://www.uniprot.org/uniprot/A0A7P0TAK3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TAK3-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TAK3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TB98", "url": "https://www.uniprot.org/uniprot/A0A7P0TB98", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TB98-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TB98-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TBE7", "url": "https://www.uniprot.org/uniprot/A0A7P0TBE7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0TBE7-1", "url": "https://www.uniprot.org/uniprot/A0A7P0TBE7-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0Z429", "url": "https://www.uniprot.org/uniprot/A0A7P0Z429", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0Z429-1", "url": "https://www.uniprot.org/uniprot/A0A7P0Z429-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0Z436", "url": "https://www.uniprot.org/uniprot/A0A7P0Z436", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0Z436-1", "url": "https://www.uniprot.org/uniprot/A0A7P0Z436-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0Z438", "url": "https://www.uniprot.org/uniprot/A0A7P0Z438", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A7P0Z438-1", "url": "https://www.uniprot.org/uniprot/A0A7P0Z438-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C3R4", "url": "https://www.uniprot.org/uniprot/H7C3R4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "H7C3R4-1", "url": "https://www.uniprot.org/uniprot/H7C3R4-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43379-1", "url": "https://www.uniprot.org/uniprot/O43379-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43379-2", "url": "https://www.uniprot.org/uniprot/O43379-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43379-3", "url": "https://www.uniprot.org/uniprot/O43379-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43379-4", "url": "https://www.uniprot.org/uniprot/O43379-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 1518, "header": "sp|O43379-1|WDR62_HUMAN Isoform 1 of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4 CANONICAL=O43379-1" }, "isoforms": [ { "isoform_ac": "A0A2R8YD43-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEFSR", "length": 414, "header": "tr|A0A2R8YD43-1|A0A2R8YD43_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=2 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36075962, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000644764.2", "url": "https://www.ensembl.org/id/ENST00000644764.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000494253.2", "url": "https://www.ensembl.org/id/ENSP00000494253.2" } ] } }, { "isoform_ac": "A0A7P0T846-1", "url": "", "sequence": { "sequence": "XLGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGQPCPLE", "length": 313, "header": "tr|A0A7P0T846-1|A0A7P0T846_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36104558, "end_pos": 36102752, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679598.1", "url": "https://www.ensembl.org/id/ENST00000679598.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504936.1", "url": "https://www.ensembl.org/id/ENSP00000504936.1" } ] } }, { "isoform_ac": "A0A7P0T8C3-1", "url": "", "sequence": { "sequence": "XIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKLRVHLAPGPGDHQLHEAALAGD", "length": 184, "header": "tr|A0A7P0T8C3-1|A0A7P0T8C3_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36092756, "end_pos": 36084653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680377.1", "url": "https://www.ensembl.org/id/ENST00000680377.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505055.1", "url": "https://www.ensembl.org/id/ENSP00000505055.1" } ] } }, { "isoform_ac": "A0A7P0T8C4-1", "url": "", "sequence": { "sequence": "XLGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGPRCREG", "length": 72, "header": "tr|A0A7P0T8C4-1|A0A7P0T8C4_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36103176, "end_pos": 36102752, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680597.1", "url": "https://www.ensembl.org/id/ENST00000680597.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505037.1", "url": "https://www.ensembl.org/id/ENSP00000505037.1" } ] } }, { "isoform_ac": "A0A7P0T8R7-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVETEFHSCCPGWSAMV", "length": 425, "header": "tr|A0A7P0T8R7-1|WDR62_HUMAN Computationally mapped isoform of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36075096, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680806.1", "url": "https://www.ensembl.org/id/ENST00000680806.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506418.1", "url": "https://www.ensembl.org/id/ENSP00000506418.1" } ] } }, { "isoform_ac": "A0A7P0T8U8-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQDPRAALHGRAGQGGGP", "length": 515, "header": "tr|A0A7P0T8U8-1|A0A7P0T8U8_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36084700, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680590.1", "url": "https://www.ensembl.org/id/ENST00000680590.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505350.1", "url": "https://www.ensembl.org/id/ENSP00000505350.1" } ] } }, { "isoform_ac": "A0A7P0T8V3-1", "url": "", "sequence": { "sequence": "XCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCR", "length": 300, "header": "tr|A0A7P0T8V3-1|A0A7P0T8V3_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36102151, "end_pos": 36092689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679422.1", "url": "https://www.ensembl.org/id/ENST00000679422.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505316.1", "url": "https://www.ensembl.org/id/ENSP00000505316.1" } ] } }, { "isoform_ac": "A0A7P0T8Z9-1", "url": "", "sequence": { "sequence": "XLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQQRKPPCMTWTLTSPRSTWPWPARTAM", "length": 91, "header": "tr|A0A7P0T8Z9-1|A0A7P0T8Z9_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36089303, "end_pos": 36086687, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679489.1", "url": "https://www.ensembl.org/id/ENST00000679489.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505399.1", "url": "https://www.ensembl.org/id/ENSP00000505399.1" } ] } }, { "isoform_ac": "A0A7P0T972-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVETEFHSCCPGWSAMV", "length": 420, "header": "tr|A0A7P0T972-1|A0A7P0T972_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36075096, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680321.1", "url": "https://www.ensembl.org/id/ENST00000680321.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505525.1", "url": "https://www.ensembl.org/id/ENSP00000505525.1" } ] } }, { "isoform_ac": "A0A7P0T975-1", "url": "", "sequence": { "sequence": "XIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSE", "length": 313, "header": "tr|A0A7P0T975-1|A0A7P0T975_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36099617, "end_pos": 36084653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680858.1", "url": "https://www.ensembl.org/id/ENST00000680858.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505451.1", "url": "https://www.ensembl.org/id/ENSP00000505451.1" } ] } }, { "isoform_ac": "A0A7P0T9D9-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEELFPAALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 1440, "header": "tr|A0A7P0T9D9-1|A0A7P0T9D9_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36105025, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680564.1", "url": "https://www.ensembl.org/id/ENST00000680564.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505582.1", "url": "https://www.ensembl.org/id/ENSP00000505582.1" } ] } }, { "isoform_ac": "A0A7P0T9F6-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLGTMMWQMAWPSTPSAATSPTAAGQSGPAKSPSRPSWMPRTWIATLPP", "length": 882, "header": "tr|A0A7P0T9F6-1|A0A7P0T9F6_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36099543, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000681625.1", "url": "https://www.ensembl.org/id/ENST00000681625.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505555.1", "url": "https://www.ensembl.org/id/ENSP00000505555.1" } ] } }, { "isoform_ac": "A0A7P0T9G3-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKEGGSSLPRYSGTDLRPHPPVAVLRV", "length": 319, "header": "tr|A0A7P0T9G3-1|A0A7P0T9G3_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36073431, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679858.1", "url": "https://www.ensembl.org/id/ENST00000679858.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505655.1", "url": "https://www.ensembl.org/id/ENSP00000505655.1" } ] } }, { "isoform_ac": "A0A7P0T9T4-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVVS", "length": 1434, "header": "tr|A0A7P0T9T4-1|A0A7P0T9T4_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36104681, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680403.1", "url": "https://www.ensembl.org/id/ENST00000680403.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505677.1", "url": "https://www.ensembl.org/id/ENSP00000505677.1" } ] } }, { "isoform_ac": "A0A7P0T9T7-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGEPCPVQSPAAVTTPPSLEWA", "length": 149, "header": "tr|A0A7P0T9T7-1|A0A7P0T9T7_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36066264, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000681809.1", "url": "https://www.ensembl.org/id/ENST00000681809.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505740.1", "url": "https://www.ensembl.org/id/ENSP00000505740.1" } ] } }, { "isoform_ac": "A0A7P0TA81-1", "url": "", "sequence": { "sequence": "XIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSAACSSGTWARRSPTA", "length": 214, "header": "tr|A0A7P0TA81-1|A0A7P0TA81_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36092734, "end_pos": 36084653, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000681302.1", "url": "https://www.ensembl.org/id/ENST00000681302.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505966.1", "url": "https://www.ensembl.org/id/ENSP00000505966.1" } ] } }, { "isoform_ac": "A0A7P0TA99-1", "url": "", "sequence": { "sequence": "MDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 390, "header": "tr|A0A7P0TA99-1|A0A7P0TA99_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36105025, "end_pos": 36103012, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680211.1", "url": "https://www.ensembl.org/id/ENST00000680211.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506102.1", "url": "https://www.ensembl.org/id/ENSP00000506102.1" } ] } }, { "isoform_ac": "A0A7P0TAH3-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGEPLSSRSLRLASYPAKKGFILSTLL", "length": 615, "header": "tr|A0A7P0TAH3-1|WDR62_HUMAN Computationally mapped isoform of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36086889, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680359.1", "url": "https://www.ensembl.org/id/ENST00000680359.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506079.1", "url": "https://www.ensembl.org/id/ENSP00000506079.1" } ] } }, { "isoform_ac": "A0A7P0TAK3-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRELFPAALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 1518, "header": "tr|A0A7P0TAK3-1|A0A7P0TAK3_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36105025, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679682.1", "url": "https://www.ensembl.org/id/ENST00000679682.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506226.1", "url": "https://www.ensembl.org/id/ENSP00000506226.1" } ] } }, { "isoform_ac": "A0A7P0TB98-1", "url": "", "sequence": { "sequence": "XCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCREMRFHHVGQTGLKLLPQMICPPWPPKVLGLQA", "length": 369, "header": "tr|A0A7P0TB98-1|A0A7P0TB98_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36102543, "end_pos": 36092689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679357.1", "url": "https://www.ensembl.org/id/ENST00000679357.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506376.1", "url": "https://www.ensembl.org/id/ENSP00000506376.1" } ] } }, { "isoform_ac": "A0A7P0TBE7-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRELFPAALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 1521, "header": "tr|A0A7P0TBE7-1|A0A7P0TBE7_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36105025, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679714.1", "url": "https://www.ensembl.org/id/ENST00000679714.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000506627.1", "url": "https://www.ensembl.org/id/ENSP00000506627.1" } ] } }, { "isoform_ac": "A0A7P0Z429-1", "url": "", "sequence": { "sequence": "XCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSEPVLQEGGGGRAWRPAGRLLPQGVLRQPKGPEPA", "length": 210, "header": "tr|A0A7P0Z429-1|A0A7P0Z429_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36101314, "end_pos": 36092689, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000681088.1", "url": "https://www.ensembl.org/id/ENST00000681088.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504920.1", "url": "https://www.ensembl.org/id/ENSP00000504920.1" } ] } }, { "isoform_ac": "A0A7P0Z436-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRELFPAALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 1406, "header": "tr|A0A7P0Z436-1|WDR62_HUMAN Computationally mapped isoform of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36105025, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000679757.1", "url": "https://www.ensembl.org/id/ENST00000679757.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505158.1", "url": "https://www.ensembl.org/id/ENSP00000505158.1" } ] } }, { "isoform_ac": "A0A7P0Z438-1", "url": "", "sequence": { "sequence": "XCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRGRALPHPHLPRPSVQPGHSIGVPGVGSPAGPGGALPRSSGRRGGL", "length": 91, "header": "tr|A0A7P0Z438-1|A0A7P0Z438_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=1 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36102774, "end_pos": 36102014, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000680739.1", "url": "https://www.ensembl.org/id/ENST00000680739.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000505170.1", "url": "https://www.ensembl.org/id/ENSP00000505170.1" } ] } }, { "isoform_ac": "H7C3R4-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGMWRMGPASESCGEDSIAPSLSRTVPGMYCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEP", "length": 375, "header": "tr|H7C3R4-1|H7C3R4_HUMAN Computationally mapped isoform of WD repeat domain 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36071714, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000427823.3", "url": "https://www.ensembl.org/id/ENST00000427823.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000413475.4", "url": "https://www.ensembl.org/id/ENSP00000413475.4" } ] } }, { "isoform_ac": "O43379-1", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 1518, "header": "sp|O43379-1|WDR62_HUMAN Isoform 1 of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36105025, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000270301.12", "url": "https://www.ensembl.org/id/ENST00000270301.12" }, { "database": "Ensembl Peptide", "id": "ENSP00000270301.6", "url": "https://www.ensembl.org/id/ENSP00000270301.6" } ] } }, { "isoform_ac": "O43379-2", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNLAPALQMCGRGHSRQPNTPSPGEIAS", "length": 483, "header": "sp|O43379-2|WDR62_HUMAN Isoform 2 of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36081871, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000587391.6", "url": "https://www.ensembl.org/id/ENST00000587391.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000465525.1", "url": "https://www.ensembl.org/id/ENSP00000465525.1" } ] } }, { "isoform_ac": "O43379-3", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEALS", "length": 414, "header": "sp|O43379-3|WDR62_HUMAN Isoform 3 of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36073657, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378860.8", "url": "https://www.ensembl.org/id/ENST00000378860.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000504870.1", "url": "https://www.ensembl.org/id/ENSP00000504870.1" } ] } }, { "isoform_ac": "O43379-4", "url": "", "sequence": { "sequence": "MAAVGSGGYARNDAGEKLPSVMAGVPARRGQSSPPPAPPICLRRRTRLSTASEETVQNRVSLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVILDPKENKQQHIFNTARKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKNQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEVSTETKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGSTFCVSYSGLLCQFNEKRVLEKWINLKVSLSSCLCVSQELIFCGCTDGIVRIFQAHSLHYLANLPKPHYLGVDVAQGLEPSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSIYIWDVKDINRVGKVWSELFHSSYVWNVEVYPEFEDQRACLPSGSFLTCSSDNTIRFWNLDSSPDSHWQKNIFSNTLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDVKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELVKVEAHDAEVLCLEYSKPETGLTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGNRDIQMISCGADKSIYFRSAQQGSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVNGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECIAKMFGHSEIITSMKFTYDCHHLITVSGDSCVFIWHLGPEITNCMKQHLLEIDHRQQQQHTNDKKRSGHPRQDTYVSTPSEIHSLSPGEQTEDDLEEECEPEEMLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADGLAFHAKRSYQPHGRWAERAGQEPLKTILDAQDLDCYFTPMKPESLENSILDSLEPQSLASLLSESESPQEAGRGHPSFLPQQKESSEASELILYSLEAEVTVTGTDSQYCRKEVEAGPGDQQGDSYLRVSSDSPKDQSPPEDSGESEADLECSFAAIHSPAPPPDPAPRFATSLPHFPGCAGPTEDELSLPEGPSVPSSSLPQTPEQEKFLRHHFETLTESPCRELFPAALGDVEASEAEDHFFNPRLSISTQFLSSLQKASRFTHTFPPRATQCLVKSPEVKLMDRGGSQPRAGTGYASPDRTHVLAAGKAEETLEAWRPPPPCLTSLASCVPASSVLPTDRNLPTPTSAPTPGLAQGVHAPSTCSYMEATASSRARISRSISLGDSEGPIVATLAQPLRRPSSVGELASLGQELQAITTATTPSLDSEGQEPALRSWGNHEARANLRLTLSSACDGLLQPPVDTQPGVTVPAVSFPAPSPVEESALRLHGSAFRPSLPAPESPGLPAHPSNPQLPEARPGIPGGTASLLEPTSGALGLLQGSPARWSEPWVPVEALPPSPLELSRVGNILHRLQTTFQEALDLYRVLVSSGQVDTGQQQARTELVSTFLWIHSQLEAECLVGTSVAPAQALPSPGPPSPPTLYPLASPDLQALLEHYSELLVQAVRRKARGH", "length": 1523, "header": "sp|O43379-4|WDR62_HUMAN Isoform 4 of WD repeat-containing protein 62 OS=Homo sapiens OX=9606 GN=WDR62 PE=1 SV=4 CANONICAL=O43379-1" }, "locus": { "chromosome": "19", "start_pos": 36105025, "end_pos": 36054972, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000401500.7", "url": "https://www.ensembl.org/id/ENST00000401500.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000384792.1", "url": "https://www.ensembl.org/id/ENSP00000384792.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 46, "start_aa": "Thr", "end_pos": 46, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr46", "evidence": [ { "id": "O43379", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43379" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 49, "start_aa": "Ser", "end_pos": 49, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser49", "evidence": [ { "id": "O43379", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43379" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 50, "start_aa": "Thr", "end_pos": 50, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr50", "evidence": [ { "id": "O43379", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43379" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O43379", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43379" }, { "id": "23301498", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23301498" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [ { "start_pos": 1049, "end_pos": 1049, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "phospho.ELM", "id": "O43379", "url": "http://phospho.elm.eu.org/byAccession/O43379.html" } ], "site_lbl": "Ser1049" }, { "start_pos": 1053, "end_pos": 1053, "kinase_uniprot_canonical_ac": "P45983-1", "kinase_gene_name": "MAPK8", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "30566428", "url": "https://glygen.org/publication/PubMed/30566428" } ], "site_lbl": "Thr1053" }, { "start_pos": 1053, "end_pos": 1053, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "16565220", "url": "https://glygen.org/publication/PubMed/16565220" }, { "database": "phospho.ELM", "id": "O43379", "url": "http://phospho.elm.eu.org/byAccession/O43379.html" }, { "database": "PubMed", "id": "25501809", "url": "https://glygen.org/publication/PubMed/25501809" }, { "database": "PubMed", "id": "30566428", "url": "https://glygen.org/publication/PubMed/30566428" } ], "site_lbl": "Thr1053" }, { "start_pos": 1070, "end_pos": 1070, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "16565220", "url": "https://glygen.org/publication/PubMed/16565220" }, { "database": "phospho.ELM", "id": "O43379", "url": "http://phospho.elm.eu.org/byAccession/O43379.html" }, { "database": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" } ], "site_lbl": "Ser1070" }, { "start_pos": 1093, "end_pos": 1093, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "16565220", "url": "https://glygen.org/publication/PubMed/16565220" }, { "database": "phospho.ELM", "id": "O43379", "url": "http://phospho.elm.eu.org/byAccession/O43379.html" } ], "site_lbl": "Ser1093" }, { "start_pos": 1101, "end_pos": 1101, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "16565220", "url": "https://glygen.org/publication/PubMed/16565220" }, { "database": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" }, { "database": "phospho.ELM", "id": "O43379", "url": "http://phospho.elm.eu.org/byAccession/O43379.html" } ], "site_lbl": "Ser1101" }, { "start_pos": 1123, "end_pos": 1123, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" }, { "database": "PubMed", "id": "19691289", "url": "https://glygen.org/publication/PubMed/19691289" }, { "database": "phospho.ELM", "id": "O43379", "url": "http://phospho.elm.eu.org/byAccession/O43379.html" } ], "site_lbl": "Ser1123" }, { "start_pos": 1140, "end_pos": 1140, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ], "site_lbl": "Thr1140" }, { "start_pos": 1144, "end_pos": 1144, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" }, { "database": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" }, { "database": "PubMed", "id": "19691289", "url": "https://glygen.org/publication/PubMed/19691289" } ], "site_lbl": "Ser1144" }, { "start_pos": 1191, "end_pos": 1191, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" } ], "site_lbl": "Thr1191" }, { "start_pos": 1219, "end_pos": 1219, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "27869121", "url": "" } ], "site_lbl": "Ser1219" }, { "start_pos": 1226, "end_pos": 1226, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" }, { "database": "phospho.ELM", "id": "O43379", "url": "http://phospho.elm.eu.org/byAccession/O43379.html" } ], "site_lbl": "Ser1226" }, { "start_pos": 1228, "end_pos": 1228, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" }, { "database": "PubMed", "id": "16565220", "url": "https://glygen.org/publication/PubMed/16565220" }, { 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Proteome Res.", "date": "2008", "authors": "Cantin GT, Yi W, Lu B, Park SK, Xu T, Lee JD, Yates JR 3rd", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" } ], "reference": [ { "type": "PubMed", "id": "18220336", "url": "https://glygen.org/publication/PubMed/18220336" } ] }, { "title": "A quantitative atlas of mitotic phosphorylation.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2008", "authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "18669648", "url": "https://glygen.org/publication/PubMed/18669648" } ] }, { "title": "Immobilized metal affinity chromatography revisited: pH/acid control toward high selectivity in phosphoproteomics.", "journal": "Journal of proteome research", "date": "2008", "authors": "Tsai CF, Wang YT, Chen YR, Lai CY, Lin PY, Pan KT, Chen JY, Khoo KH, Chen YJ", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "18707149", "url": "https://glygen.org/publication/PubMed/18707149" } ] }, { "title": "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.", "journal": "Analytical chemistry", "date": "2008", "authors": "Wang B, Malik R, Nigg EA, Korner R", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" } ] }, { "title": "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.", "journal": "Analytical chemistry", "date": "2009", "authors": "Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "19413330", "url": "https://glygen.org/publication/PubMed/19413330" } ] }, { "title": "Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment.", "journal": "Proteomics", "date": "2009", "authors": "Nagano K, Shinkawa T, Mutoh H, Kondoh O, Morimoto S, Inomata N, Ashihara M, Ishii N, Aoki Y, Haramura M", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "19415658", "url": "https://glygen.org/publication/PubMed/19415658" } ] }, { "title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.", "journal": "Molecular & cellular proteomics : MCP", "date": "2009", "authors": "Pan C, Olsen JV, Daub H, Mann M", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "19651622", "url": "https://glygen.org/publication/PubMed/19651622" } ] }, { "title": "Phosphoproteomic analysis of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Brill LM, Xiong W, Lee KB, Ficarro SB, Crain A, Xu Y, Terskikh A, Snyder EY, Ding S", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "19664994", "url": "https://glygen.org/publication/PubMed/19664994" } ] }, { "title": "Phosphorylation dynamics during early differentiation of human embryonic stem cells.", "journal": "Cell stem cell", "date": "2009", "authors": "Van Hoof D, Munoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "19664995", "url": "https://glygen.org/publication/PubMed/19664995" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages.", "journal": "Journal of proteome research", "date": "2009", "authors": "Malik R, Lenobel R, Santamaria A, Ries A, Nigg EA, Korner R", "evidence": [ { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "19691289", "url": "https://glygen.org/publication/PubMed/19691289" } ] }, { "title": "A novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation.", "journal": "Molecular biology of the cell", "date": "2010", "authors": "Wasserman T, Katsenelson K, Daniliuc S, Hasin T, Choder M, Aronheim A", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" } ], "reference": [ { "type": "PubMed", "id": "19910486", "url": "https://glygen.org/publication/PubMed/19910486" } ] }, { "title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.", "journal": "Science signaling", "date": "2010", "authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "iPTMnet", "id": "O43379-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379-1" } ], "reference": [ { "type": "PubMed", "id": "20068231", "url": "https://glygen.org/publication/PubMed/20068231" } ] }, { "title": "Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.", "journal": "Nature", "date": "2010", "authors": "Bilguvar K, Ozturk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoglu D, Tuysuz B, Caglayan AO, Gokben S, Kaymakcalan H, Barak T, Bakircioglu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dincer A, Johnson MH, Bronen RA, Kocer N, Per H, Mane S, Pamir MN, Yalcinkaya C, Kumandas S, Topcu M, Ozmen M, Sestan N, Lifton RP, State MW, Gunel M", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "reference": [ { "type": "PubMed", "id": "20729831", "url": "https://glygen.org/publication/PubMed/20729831" } ] }, { "title": "Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture.", "journal": "Nature genetics", "date": "2010", "authors": "Yu TW, Mochida GH, Tischfield DJ, Sgaier SK, Flores-Sarnat L, Sergi CM, Topcu M, McDonald MT, Barry BJ, Felie JM, Sunu C, Dobyns WB, Folkerth RD, Barkovich AJ, Walsh CA", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "reference": [ { "type": "PubMed", "id": "20890278", "url": "https://glygen.org/publication/PubMed/20890278" } ] }, { "title": "WDR62 is associated with the spindle pole and is mutated in human microcephaly.", "journal": "Nature genetics", "date": "2010", "authors": "Nicholas AK, Khurshid M, Desir J, Carvalho OP, Cox JJ, Thornton G, Kausar R, Ansar M, Ahmad W, Verloes A, Passemard S, Misson JP, Lindsay S, Gergely F, Dobyns WB, Roberts E, Abramowicz M, Woods CG", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "dbSNP", "id": "rs387907083", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs387907083" } ], "reference": [ { "type": "PubMed", "id": "20890279", "url": "https://glygen.org/publication/PubMed/20890279" } ] }, { "title": "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.", "journal": "Science signaling", "date": "2011", "authors": "Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" } ], "reference": [ { "type": "PubMed", "id": "21406692", "url": "https://glygen.org/publication/PubMed/21406692" } ] }, { "title": "Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations.", "journal": "Clin. Genet.", "date": "2011", "authors": "Bhat V, Girimaji SC, Mohan G, Arvinda HR, Singhmar P, Duvvari MR, Kumar A", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "reference": [ { "type": "PubMed", "id": "21496009", "url": "https://glygen.org/publication/PubMed/21496009" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" }, { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.", "journal": "Journal of proteome research", "date": "2013", "authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43379", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43379" } ], "reference": [ { "type": "PubMed", "id": "23301498", "url": "https://glygen.org/publication/PubMed/23301498" } ] }, { "title": "Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins.", "journal": "J. Biol. Chem.", "date": "2013", "authors": "Cohen-Katsenelson K, Wasserman T, Darlyuk-Saadon I, Rabner A, Glaser F, Aronheim A", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "reference": [ { "type": "PubMed", "id": "23341463", "url": "https://glygen.org/publication/PubMed/23341463" } ] }, { "title": "Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules.", "journal": "Journal of cell science", "date": "2015", "authors": "Lim NR, Yeap YY, Zhao TT, Yip YY, Wong SC, Xu D, Ang CS, Williamson NA, Xu Z, Bogoyevitch MA, Ng DC", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" } ], "reference": [ { "type": "PubMed", "id": "25501809", "url": "https://glygen.org/publication/PubMed/25501809" } ] }, { "title": "Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.", "journal": "eLife", "date": "2015", "authors": "Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "reference": [ { "type": "PubMed", "id": "26297806", "url": "https://glygen.org/publication/PubMed/26297806" } ] }, { "title": "Mutations in MAPKBP1 cause juvenile or late-onset cilia-independent nephronophthisis.", "journal": "Am. J. Hum. Genet.", "date": "2017", "authors": "Macia MS, Halbritter J, Delous M, Bredrup C, Gutter A, Filhol E, Mellgren AEC, Leh S, Bizet A, Braun DA, Gee HY, Silbermann F, Henry C, Krug P, Bole-Feysot C, Nitschke P, Joly D, Nicoud P, Paget A, Haugland H, Brackmann D, Ahmet N, Sandford R, Cengiz N, Knappskog PM, Boman H, Linghu B, Yang F, Oakeley EJ, Saint Mezard P, Sailer AW, Johansson S, Rodahl E, Saunier S, Hildebrandt F, Benmerah A", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "reference": [ { "type": "PubMed", "id": "28089251", "url": "https://glygen.org/publication/PubMed/28089251" } ] }, { "title": "PLK1-mediated phosphorylation of WDR62/MCPH2 ensures proper mitotic spindle orientation.", "journal": "Human molecular genetics", "date": "2017", "authors": "Miyamoto T, Akutsu SN, Fukumitsu A, Morino H, Masatsuna Y, Hosoba K, Kawakami H, Yamamoto T, Shimizu K, Ohashi H, Matsuura S", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" } ], "reference": [ { "type": "PubMed", "id": "28973348", "url": "https://glygen.org/publication/PubMed/28973348" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43379", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43379" }, { "database": "O-GlcNAc Atlas", "id": "O43379", "url": "https://oglcnac.org/atlas/detail/O43379" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.", "journal": "PLoS biology", "date": "2018", "authors": "Xu D, Yao M, Wang Y, Yuan L, Hoeck JD, Yu J, Liu L, Yeap YYC, Zhang W, Zhang F, Feng Y, Ma T, Wang Y, Ng DCH, Niu X, Su B, Behrens A, Xu Z", "evidence": [ { "database": "iPTMnet", "id": "O43379", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43379" } ], "reference": [ { "type": "PubMed", "id": "30566428", "url": "https://glygen.org/publication/PubMed/30566428" } ] }, { "title": "Neurological outcome in WDR62 primary microcephaly.", "journal": "Developmental medicine and child neurology", "date": "2022", "authors": "Ruaud L, Drunat S, Elmaleh-Berges M, Ernault A, Guilmin Crepon S, El Ghouzzi V, Auvin S, Verloes A, Passemard S", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" } ], "reference": [ { "type": "PubMed", "id": "35726608", "url": "https://glygen.org/publication/PubMed/35726608" } ] }, { "title": "WD repeat domain 62 (WDR62) promotes resistance of colorectal cancer to oxaliplatin through modulating mitogen-activated protein kinase (MAPK) signaling.", "journal": "Bioengineered", "date": "2022", "authors": "Cai J, Su L, Luo W", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" } ], "reference": [ { "type": "PubMed", "id": "35758246", "url": "https://glygen.org/publication/PubMed/35758246" } ] }, { "title": "WDR62 variants contribute to congenital heart disease by inhibiting cardiomyocyte proliferation.", "journal": "Clinical and translational medicine", "date": "2022", "authors": "Hao L, Ma J, Wu F, Ma X, Qian M, Sheng W, Yan T, Tang N, Jiang X, Zhang B, Xiao D, Qian Y, Zhang J, Jiang N, Zhou W, Chen W, Ma D, Huang G", "evidence": [ { "database": "RefSeq", "id": "NP_001077430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077430" } ], "reference": [ { "type": "PubMed", "id": "35808830", "url": "https://glygen.org/publication/PubMed/35808830" } ] } ], "pathway": [ { "id": "hsa:284403", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:284403", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "F1M5K2-1", "protein_name": "WD repeat domain 62", "gene_name": "Wdr62", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MMAALAAGGYARSDTIEKLSSVMAGVPARRNQSSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHRPAVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEASTEAKVTSTMPLVGRSGILGELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKRVLDKWINLKVSLSSCLCVSDELIFCGCTDGIVRIFQAHSLLYLTNLPKPHYLGIDVAQGLDSSFLFHRKAEAVYPDTVALTFDPIHQWLSCVYKDHSVYIWDVKDINEVSKIWSELFHSSFVWNVEVYPEFEDQRACLPSGTFLTCSSDNTIRFWNMDSGSDTQWRKNIFSDSLLKVVYVENDIQHLQDMSHFPDRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETGVTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGTRDVQMISCGADKSIYFRSAQQTSDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISVIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHLGPEITTCMKQHLMEINHQEQQHLPKDQKWSGPPSQETSASTPSEIRSLSPGEQTEDEMEEECEPEETLKTPSKESLDPDPRCLLTNGKLPLWAKRLLGDDDVTDSSAFHAKRSYQPHGRWAERAEQEPLKTILDAWALDSYFTPMKPGNLEDSVLDSVEPQNLAGLLSECSPENGHTAPGEGLVSYLCHSESGSPKEDSRGHPSYLPLQREGTETRELILCSPEVEVTVTGMHREYYEEAEAGPEDQQGDSYLRVSSVSSKDQSPPEDSGESEAELECSFAAAHVSAPRTDPGPHLTMTGKPEHSSTDELAQPGVPGLGNGSLPQTPEQEKFLRHHFETLTDAPAEELFPGSLGDIKISETDDYFFNPRLSISTQFLSRLQKTSRFPPRLPLHLMKSPEVQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQMAEETPEASCLPTPPITGLASCVPPSSVIPTDRKPPTPTSGLTTGREQSIPAPSPCSYLESTTSSHAKMTRSTSLGDSEGPVTGELPRPLHKPVSPGQEPQAVPTTVALTSSVKGHEPALPAWGNHEARASLRLTLSSVCEQLLSPPQLEPPTTPVWSQEAVDVPPSMAVTVASFSAPSPEDMSTLGLHSSVFLPKTSASGPLTPPAHPNSLQLLETRSRMPGSTPALLEPTPDASSGSPDSPGHCGEPGRRAEVPPPGPLELDSVESVLYRLQTAFQEALDLYRMLASSNQLGAEQQQAQTELASAFHWIHHQLEASNCVGAASVAPPLTLPSPGPPSPPTLCPLASPNLQALLEHYSELLVQAVRRKVRGD", "length": 1551 }, "evidence": [ { "id": "45921290", "url": "http://www.informatics.jax.org/homology/45921290", "database": "MGI" }, { "id": "O43379", "url": "https://omabrowser.org/oma/group/O43379/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q3U3T8-1", "protein_name": "WD repeat-containing protein 62", "gene_name": "Wdr62", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MAALAAGGYTRSDTIEKLSSVMAGVPARRNQSSPPPAPPLCLRRRTRLAAAPEDTVQNRVTLEKVLGITAQNSSGLTCDPGTGHVAYLAGCVVVVLNPKENKQQHIFNTTRKSLSALAFSPDGKYIVTGENGHRPTVRIWDVEEKTQVAEMLGHKYGVACVAFSPNMKHIVSMGYQHDMVLNVWDWKKDIVVASNKVSCRVIALSFSEDSSYFVTVGNRHVRFWFLEASTEAKVTSTVPLVGRSGILGELHNNIFCGVACGRGRMAGNTFCVSYSGLLCQFNEKRVLDKWINLKVSLSSCLCVSDELIFCGCTDGIVRIFQAHSLLYLTNLPKPHYLGVDVAHGLDSSFLFHRKAEAVYPDTVALTFDPVHQWLSCVYKDHSIYIWDVKDIDEVSKIWSELFHSSFVWNVEVYPEFEDQRACLPSGTFLTCSSDNTIRFWNLDSASDTRWQKNIFSDSLLKVVYVENDIQHLQDLSHFPDRGSENGTPMDMKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETGVTLLASASRDRLIHVLNVEKNYNLEQTLDDHSSSITAIKFAGTRDVQMISCGADKSIYFRSAQQASDGLHFVRTHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTVSGKQKKCYKGSQGDEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHLGPEITTCMKQHLLEINHQEQQQQPKDQKWSGPPSQETYASTPSEIRSLSPGEQTEDEMEEECEPEELLKTPSKDSLDPDPRCLLTNGKLPLWAKRLLGDDDVADSSAFHAKRSYQPHGRWAERAEQEPLKTILDAWSLDSYFTPMKPENLQDSVLDSVEPQNLAGLLSECSLGNGHTSPGEGLVSYLLHPELGSPKEDNRGHPSYLPLQREATEASELILCSPEAEVSLTGMHREYYEEETEAGPEDQQGDTYLRVSSVSSKDQSPPEDSGESEAELECSFAAAHSSAPQTDPGPHLTMTAGKPEYPSTEELSQPELPGLGNGSLPQTPEQEKFLRHHFETLTDAPTEELFHGSLGDIKISETEDYFFNPRLSISTQFLSRLQKTSRCPPRLPLHLMKSPEAQPVGQGGNQPKAGPLRAGTGYMSSDGTNVLSGQKAEETQEALSLLDRKPPTPTSVLTTGREQSISAPSSCSYLESTTSSHAKTTRSISLGDSEGPVTAELPQSLHKPLSPGQELQAIPTTVALTSSIKDHEPAPLSWGNHEARASLKLTLSSVCEQLLSPPPQEPPITHVWSQEPVDVPPSMAVTVASFCAPSPVDMSTLGLHSSMFLPKTSASGPLTPPAHLQLLETRSRVPGSTAALLEPTPDASGVIADSPGHWDTEVPTPELLGSVESVLHRLQTAFQEALDLYRMLVSSSQLGPEQQQAQTELASTFHWILNQLEASNCMAAANLAPPQTLPSPDPLSLPTLCPLASPNLQALLEHYSELLVQAVRRKARGD", "length": 1523 }, "evidence": [ { "id": "45921290", "url": "http://www.informatics.jax.org/homology/45921290", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 7, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "centriolar satellite", "id": "GO:0034451", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034451", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "spindle pole", "id": "GO:0000922", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "centrosome", "id": "GO:0005813", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "centriole", "id": "GO:0005814", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005814", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "mitotic spindle", "id": "GO:0072686", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "cerebral cortex development", "id": "GO:0021987", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0021987", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "regulation of neuron differentiation", "id": "GO:0045664", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045664", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "neurogenesis", "id": "GO:0022008", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022008", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "positive regulation of neuroblast proliferation", "id": "GO:0002052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002052", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "regulation of centrosome cycle", "id": "GO:0046605", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046605", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "mitotic spindle organization", "id": "GO:0007052", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007052", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "centriole replication", "id": "GO:0007099", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007099", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" }, { "name": "positive regulation of neuron migration", "id": "GO:2001224", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001224", "evidence": [ { "database": "UniProtKB", "id": "O43379", "url": "https://www.uniprot.org/uniprot/O43379" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 485, "end_pos": 487, "annotation": "n_glycosylation_sequon" }, { "start_pos": 72, "end_pos": 74, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [ 46, 49, 50 ], "snv_sites": [ 14, 46, 50, 110, 170, 209, 254, 380, 469, 511, 571, 602, 608, 696, 704, 791, 850, 855, 912, 914, 980, 1006, 1104, 1146, 1226, 1293, 1371, 1457 ], "glycation_sites": [], "phosphorylation_sites": [ 6, 9, 33, 46, 49, 50, 52, 156, 164, 399, 501, 614, 684, 814, 819, 897, 944, 974, 975, 987, 992, 995, 1049, 1053, 1070, 1093, 1101, 1123, 1140, 1144, 1191, 1219, 1226, 1228, 1232, 1248, 1249, 1268, 1342, 1348, 1405, 1430, 1435, 1436, 1441 ], "sequon_annotation_sites": [ { "start_pos": 485, "end_pos": 487 }, { "start_pos": 72, "end_pos": 74 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 4 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 4 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 46 }, { "field": "total_sites", "count": 45 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 30 }, { "field": "total_sites", "count": 28 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 9 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 21 }, { "field": "total_sites", "count": 20 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 33 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }