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"MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O43312", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43312" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43312" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"MLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIP", "length": 207, "header": "tr|E5RJX3-1|MTSS1_HUMAN Computationally mapped isoform of Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=1 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124568396, "end_pos": 124557690, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522118.1", "url": "https://www.ensembl.org/id/ENST00000522118.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000428145.1", "url": "https://www.ensembl.org/id/ENSP00000428145.1" } ] } }, { "isoform_ac": "E7EWW5-1", "url": "", "sequence": { "sequence": "MNKYFFYILENCGFDSSKDPREEGHLFQKLVFQQAVLGSLFFAGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 645, "header": "tr|E7EWW5-1|MTSS1_HUMAN Computationally mapped isoform of Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=1 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124568666, "end_pos": 124552995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000524090.5", "url": "https://www.ensembl.org/id/ENST00000524090.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428319.1", "url": "https://www.ensembl.org/id/ENSP00000428319.1" } ] } }, { "isoform_ac": "H0YAZ8-1", "url": "", "sequence": { "sequence": "XGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSS", "length": 286, "header": "tr|H0YAZ8-1|H0YAZ8_HUMAN Computationally mapped isoform of MTSS I-BAR domain containing 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=1 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124568538, "end_pos": 124555799, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000523179.5", "url": "https://www.ensembl.org/id/ENST00000523179.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428348.1", "url": "https://www.ensembl.org/id/ENSP00000428348.1" } ] } }, { "isoform_ac": "H0YB53-1", "url": "", "sequence": { "sequence": "XWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQNSSSSASSEASETCQSVSECSSPTSVSSGSTMGAWVSTEKLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 543, "header": "tr|H0YB53-1|H0YB53_HUMAN Computationally mapped isoform of MTSS I-BAR domain containing 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=1 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124565727, "end_pos": 124552993, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000519168.5", "url": "https://www.ensembl.org/id/ENST00000519168.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000428685.1", "url": "https://www.ensembl.org/id/ENSP00000428685.1" } ] } }, { "isoform_ac": "H0YBL3-1", "url": "", "sequence": { "sequence": "XSLGGSRHWLQVFPLSVPEGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALI", "length": 184, "header": "tr|H0YBL3-1|H0YBL3_HUMAN Computationally mapped isoform of MTSS I-BAR domain containing 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=1 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124727616, "end_pos": 124568429, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000522162.1", "url": "https://www.ensembl.org/id/ENST00000522162.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000429752.1", "url": "https://www.ensembl.org/id/ENSP00000429752.1" } ] } }, { "isoform_ac": "O43312-1", "url": "", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 755, "header": "sp|O43312-1|MTSS1_HUMAN Isoform 1 of Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=2 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124727955, "end_pos": 124552995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000518547.6", "url": "https://www.ensembl.org/id/ENST00000518547.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000429064.1", "url": "https://www.ensembl.org/id/ENSP00000429064.1" } ] } }, { "isoform_ac": "O43312-2", "url": "", "sequence": { "sequence": "MLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 473, "header": "sp|O43312-2|MTSS1_HUMAN Isoform 2 of Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=2 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124568396, "end_pos": 124552995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000431961.6", "url": "https://www.ensembl.org/id/ENST00000431961.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000393606.2", "url": "https://www.ensembl.org/id/ENSP00000393606.2" } ] } }, { "isoform_ac": "O43312-4", "url": "", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQNSSSSASSEASETCQSVSECSSPTSVSSGSTMGAWVSTEKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 730, "header": "sp|O43312-4|MTSS1_HUMAN Isoform 4 of Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=2 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124727955, "end_pos": 124552995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378017.7", "url": "https://www.ensembl.org/id/ENST00000378017.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000367256.3", "url": "https://www.ensembl.org/id/ENSP00000367256.3" } ] } }, { "isoform_ac": "O43312-5", "url": "", "sequence": { "sequence": "MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQLRTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALIDCLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKVDTLGRGDIQPQLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITHLQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSSLNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKSPSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAHYYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPAAAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQTTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKRPASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVPDLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSIPEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVKLKKTTTNDRSAPRFS", "length": 759, "header": "sp|O43312-5|MTSS1_HUMAN Isoform 5 of Protein MTSS 1 OS=Homo sapiens OX=9606 GN=MTSS1 PE=1 SV=2 CANONICAL=O43312-1" }, "locus": { "chromosome": "8", "start_pos": 124727955, "end_pos": 124552995, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000325064.9", "url": "https://www.ensembl.org/id/ENST00000325064.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000322804.5", "url": "https://www.ensembl.org/id/ENSP00000322804.5" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 197, "start_aa": "Thr", "end_pos": 197, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr197", "evidence": [ { "id": "O43312", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43312" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 200, "start_aa": "Ser", "end_pos": 200, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser200", "evidence": [ { "id": "O43312", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43312" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "28657654", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28657654" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 545, "start_aa": "Ser", "end_pos": 545, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser545", "evidence": [ { "id": "O43312", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43312" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 546, "start_aa": "Ser", "end_pos": 546, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser546", "evidence": [ { "id": "O43312", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43312" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 547, "start_aa": "Thr", "end_pos": 547, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr547", "evidence": [ { "id": "O43312", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43312" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 576, "start_aa": "Thr", "end_pos": 576, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr576", "evidence": [ { "id": "O43312", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43312" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] } ], "phosphorylation": [ { "start_pos": 258, "end_pos": 258, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" }, { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "phospho.ELM", "id": "O43312", "url": "http://phospho.elm.eu.org/byAccession/O43312.html" } ], "site_lbl": "Thr258" }, { "start_pos": 261, "end_pos": 261, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" }, { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" }, { "database": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" }, { "database": "phospho.ELM", "id": "O43312", "url": "http://phospho.elm.eu.org/byAccession/O43312.html" } ], "site_lbl": "Ser261" }, { "start_pos": 262, "end_pos": 262, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" } ], "site_lbl": "Ser262" }, { "start_pos": 271, "end_pos": 271, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" } ], "site_lbl": "Ser271" }, { "start_pos": 322, "end_pos": 322, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" }, { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" }, { "database": "PubMed", "id": "24318128", "url": "https://glygen.org/publication/PubMed/24318128" }, { "database": "PubMed", "id": "29175021", "url": "https://glygen.org/publication/PubMed/29175021" } ], "site_lbl": "Ser322" }, { "start_pos": 326, "end_pos": 326, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" }, { "database": "PubMed", "id": "30858428", "url": "https://glygen.org/publication/PubMed/30858428" } ], "site_lbl": "Ser326" }, { "start_pos": 425, "end_pos": 425, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" } ], "site_lbl": "Thr425" }, { "start_pos": 603, "end_pos": 603, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" } ], "site_lbl": "Thr603" }, { "start_pos": 644, "end_pos": 644, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" }, { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ], "site_lbl": "Ser644" }, { "start_pos": 647, "end_pos": 647, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" } ], "site_lbl": "Ser647" }, { "start_pos": 649, "end_pos": 649, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" }, { "database": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ], "site_lbl": "Ser649" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "MIM, a potential metastasis suppressor gene in bladder cancer.", "journal": "Neoplasia", "date": "2002", "authors": "Lee YG, Macoska JA, Korenchuk S, Pienta KJ", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" }, { "database": "RefSeq", "id": "NP_001269900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269900" } ], "reference": [ { "type": "PubMed", "id": "12082544", "url": "https://glygen.org/publication/PubMed/12082544" } ] }, { "title": "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta.", "journal": "Biochem. J.", "date": "2003", "authors": "Woodings Jacquelyn A, Sharp Stewart J, Machesky Laura M", "evidence": [ { "database": "UniProtKB", "id": "O43312", "url": "https://www.uniprot.org/uniprot/O43312" } ], "reference": [ { "type": "PubMed", "id": "12570871", "url": "https://glygen.org/publication/PubMed/12570871" } ] }, { "title": "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Yamagishi A, Masuda M, Ohki T, Onishi H, Mochizuki N", "evidence": [ { "database": "RefSeq", "id": "NP_001269900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269900" } ], "reference": [ { "type": "PubMed", "id": "14752106", "url": "https://glygen.org/publication/PubMed/14752106" } ] }, { "title": "Phosphoproteome of resting human platelets.", "journal": "J. Proteome Res.", "date": "2008", "authors": "Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A", "evidence": [ { "database": "UniProtKB", "id": "E5RJX3", "url": "https://www.uniprot.org/uniprot/E5RJX3" }, { "database": "iPTMnet", "id": "O43312-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312-1" } ], "reference": [ { "type": "PubMed", "id": "18088087", "url": "https://glygen.org/publication/PubMed/18088087" } ] }, { "title": "Exploring the human leukocyte phosphoproteome using a microfluidic reversed-phase-TiO2-reversed-phase high-performance liquid chromatography phosphochip coupled to a quadrupole time-of-flight mass spectrometer.", "journal": "Analytical chemistry", "date": "2010", "authors": "Raijmakers R, Kraiczek K, de Jong AP, Mohammed S, Heck AJ", "evidence": [ { "database": "iPTMnet", "id": "O43312-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312-1" } ], "reference": [ { "type": "PubMed", "id": "20058876", "url": "https://glygen.org/publication/PubMed/20058876" } ] }, { "title": "SCF beta-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration.", "journal": "Oncotarget", "date": "2013", "authors": "Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H, Wei W", "evidence": [ { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" } ], "reference": [ { "type": "PubMed", "id": "24318128", "url": "https://glygen.org/publication/PubMed/24318128" } ] }, { "title": "Quantitative proteomics identifies altered O-GlcNAcylation of structural, synaptic and memory-associated proteins in Alzheimer's disease.", "journal": "The Journal of pathology", "date": "2017", "authors": "Wang S, Yang F, Petyuk VA, Shukla AK, Monroe ME, Gritsenko MA, Rodland KD, Smith RD, Qian WJ, Gong CX, Liu T", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43312", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43312" } ], "reference": [ { "type": "PubMed", "id": "28657654", "url": "https://glygen.org/publication/PubMed/28657654" } ] }, { "title": "PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma.", "journal": "Neoplasia (New York, N.Y.)", "date": "2018", "authors": "Zeleniak AE, Huang W, Fishel ML, Hill R", "evidence": [ { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" } ], "reference": [ { "type": "PubMed", "id": "29175021", "url": "https://glygen.org/publication/PubMed/29175021" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43312", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43312" }, { "database": "O-GlcNAc Atlas", "id": "O43312", "url": "https://oglcnac.org/atlas/detail/O43312" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control.", "journal": "Scientific reports", "date": "2019", "authors": "Petrov P, Sarapulov AV, Eory L, Scielzo C, Scarfo L, Smith J, Burt DW, Mattila PK", "evidence": [ { "database": "iPTMnet", "id": "O43312", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43312" } ], "reference": [ { "type": "PubMed", "id": "30858428", "url": "https://glygen.org/publication/PubMed/30858428" } ] }, { "title": "A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.", "journal": "Theranostics", "date": "2020", "authors": "Hu Y, Wang F, Xu F, Fang K, Fang Z, Shuai X, Cai K, Chen J, Hu P, Chen D, Xu P, Hu C, Zeng Z, Zhong J, Li W, Tang J, Huang M, Zhao Y, Wang C, Zhao G", "evidence": [ { "database": "RefSeq", "id": "NP_001269900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269900" } ], "reference": [ { "type": "PubMed", "id": "32929338", "url": "https://glygen.org/publication/PubMed/32929338" } ] }, { "title": "Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Maynard JC, Chalkley RJ", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O43312", "url": "https://oglcnac.org/atlas/detail/O43312" } ], "reference": [ { "type": "PubMed", "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "title": "Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.", "journal": "Acta biochimica et biophysica Sinica", "date": "2021", "authors": "Li T, Zuo X, Meng X", "evidence": [ { "database": "RefSeq", "id": "NP_001269900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269900" } ], "reference": [ { "type": "PubMed", "id": "33686422", "url": "https://glygen.org/publication/PubMed/33686422" } ] }, { "title": "Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.", "journal": "Leukemia", "date": "2021", "authors": "Grandits AM, Nguyen CH, Schlerka A, Hackl H, Sill H, Etzler J, Heyes E, Stoiber D, Grebien F, Heller G, Wieser R", "evidence": [ { "database": "RefSeq", "id": "NP_001269900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269900" } ], "reference": [ { "type": "PubMed", "id": "33782537", "url": "https://glygen.org/publication/PubMed/33782537" } ] }, { "title": "MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.", "journal": "Nature cancer", "date": "2020", "authors": "Cong M, Wang Y, Yang Y, Lian C, Zhuang X, Li X, Zhang P, Liu Y, Tang J, Yang Q, Zhang X, Xiong H, Hu R, Hu G", "evidence": [ { "database": "RefSeq", "id": "NP_001269900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269900" } ], "reference": [ { "type": "PubMed", "id": "35122005", "url": "https://glygen.org/publication/PubMed/35122005" } ] }, { "title": "Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-\u03b4 to regulate adipogenesis.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "date": "2023-04", "authors": "Chen Meng, Dong Yuan, Tian Lijie, Zhou Jie, Zhu Endong, Yuan Hairui, Li Xiaoxia, Wang Baoli", "evidence": [ { "database": "RefSeq", "id": "NP_001269900", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269900" } ], "reference": [ { "type": "PubMed", "id": "36906292", "url": "https://glygen.org/publication/PubMed/36906292" } ] }, { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43312", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43312" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "pathway": [ { "id": "hsa:9788", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9788", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I6AWT9-1", "protein_name": "MTSS I-BAR domain containing 1", "gene_name": "Mtss1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": 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}, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 11 }, { "field": "total_sites", "count": 11 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 22 }, { "field": "total_sites", "count": 21 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 5 }, { "field": "total_sites", "count": 5 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 17 }, { "field": "total_sites", "count": 16 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 17 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }