{ "uniprot_canonical_ac": "O43187-1", "uniprot_ac": "O43187", "uniprot_id": "IRAK2_HUMAN", "mass": { "chemical_mass": 69433.0, "monoisotopic_mass": 69433.0 }, "refseq": { "ac": "NP_001561", "name": "interleukin-1 receptor-associated kinase-like 2", "summary": "IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561" }, "gene_names": [ { "name": "IRAK2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43187", "id": "O43187" }, { "name": "IRAK-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561", "id": "NP_001561" }, { "name": "IRAK2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561", "id": "NP_001561" } ], "protein_names": [ { "name": "Interleukin-1 receptor-associated kinase-like 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43187" }, { "name": "IRAK-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43187" }, { "name": "interleukin-1 receptor-associated kinase-like 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561", "id": "NP_001561" } ], "function": [ { "annotation": "Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.", "evidence": [ { "database": "UniProtKB", "id": "O43187", "url": "https://www.uniprot.org/uniprot/O43187#function" }, { "database": "PubMed", "id": "9374458", "url": "https://glygen.org/publication/PubMed/9374458" }, { "database": "PubMed", "id": "10383454", "url": "https://glygen.org/publication/PubMed/10383454" } ] }, { "annotation": "IRAK2 Has a Critical Role in Promoting Feed-Forward Amplification of Epidermal Inflammatory Responses.", "evidence": [ { "database": "RefSeq", "id": "NP_001561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561" }, { "database": "PubMed", "id": "33864770", "url": "https://glygen.org/publication/PubMed/33864770" } ] }, { "annotation": "IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561" } ] }, { "annotation": "IRAK2 is associated with systemic lupus erythematosus risk.", "evidence": [ { "database": "RefSeq", "id": "NP_001561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561" }, { "database": "PubMed", "id": "31650390", "url": "https://glygen.org/publication/PubMed/31650390" } ] }, { "annotation": "Multi-locus SNP analyses of interleukin 1 receptor associated kinases 2 gene polymorphisms with the susceptibility to rheumatoid arthritis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561" }, { "database": "PubMed", "id": "35588430", "url": "https://glygen.org/publication/PubMed/35588430" } ] }, { "annotation": "MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561" }, { "database": "PubMed", "id": "31995744", "url": "https://glygen.org/publication/PubMed/31995744" } ] }, { "annotation": "The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001561" }, { "database": "PubMed", "id": "33799071", "url": "https://glygen.org/publication/PubMed/33799071" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "69.63", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "69.41", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "69.38", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "67.94", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "69.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "78.95", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "69.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "77.02", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "70.66", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "72.93", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000134070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000134070" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O43187", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43187" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial 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"evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000256458.5", "url": "https://www.ensembl.org/id/ENST00000256458.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000256458.4", "url": "https://www.ensembl.org/id/ENSP00000256458.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O43187", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43187" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [ { "start_pos": 144, "end_pos": 144, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O43187", "url": "https://www.uniprot.org/uniprot/O43187" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O43187", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O43187" } ], "site_lbl": "Ser144" } ], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Inducible degradation of IkappaBalpha by the proteasome requires interaction with the F-box protein h-betaTrCP.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Kroll M, Margottin F, Kohl A, Renard P, Durand H, Concordet JP, Bachelerie F, Arenzana-Seisdedos F, Benarous R", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "10075690", "url": "https://glygen.org/publication/PubMed/10075690" } ] }, { "title": "Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Bertin J, Nir WJ, Fischer CM, Tayber OV, Errada PR, Grant JR, Keilty JJ, Gosselin ML, Robison KE, Wong GH, Glucksmann MA, DiStefano PS", "evidence": [ { "database": "Reactome", "id": "R-HSA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-168638" } ], "reference": [ { "type": "PubMed", "id": "10224040", "url": "https://glygen.org/publication/PubMed/10224040" } ] }, { "title": "Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G", "evidence": [ { "database": "Reactome", "id": "R-HSA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-168638" } ], "reference": [ { "type": "PubMed", "id": "10329646", "url": "https://glygen.org/publication/PubMed/10329646" } ] }, { "title": "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z", "evidence": [ { "database": "UniProtKB", "id": "O43187", "url": "https://www.uniprot.org/uniprot/O43187" } ], "reference": [ { "type": "PubMed", "id": "10383454", "url": "https://glygen.org/publication/PubMed/10383454" } ] }, { "title": "ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway.", "journal": "Genes & development", "date": "1999", "authors": "Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway CA, Ghosh S", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "10465784", "url": "https://glygen.org/publication/PubMed/10465784" } ] }, { "title": "Molecular dissection of the interactions among IkappaBalpha, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IkappaBalpha.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Hattori K, Hatakeyama S, Shirane M, Matsumoto M, Nakayama K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "10514433", "url": "https://glygen.org/publication/PubMed/10514433" } ] }, { "title": "TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Kishimoto K, Matsumoto K, Ninomiya-Tsuji J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "10702308", "url": "https://glygen.org/publication/PubMed/10702308" } ] }, { "title": "Activation of NF-kappa B by the dsRNA-dependent protein kinase, PKR involves the I kappa B kinase complex.", "journal": "Oncogene", "date": "2000", "authors": "Gil J, Alcami J, Esteban M", "evidence": [ { "database": "Reactome", "id": "R-HSA-445989", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-445989" } ], "reference": [ { "type": "PubMed", "id": "10723127", "url": "https://glygen.org/publication/PubMed/10723127" } ] }, { "title": "Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.", "journal": "FEBS letters", "date": "2000", "authors": "Sakurai H, Miyoshi H, Mizukami J, Sugita T", "evidence": [ { "database": "Reactome", "id": "R-HSA-937042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-937042" } ], "reference": [ { "type": "PubMed", "id": "10838074", "url": "https://glygen.org/publication/PubMed/10838074" } ] }, { "title": "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor.", "journal": "Nature cell biology", "date": "2000", "authors": "Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "10854325", "url": "https://glygen.org/publication/PubMed/10854325" } ] }, { "title": "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.", "journal": "Molecular cell", "date": "2000", "authors": "Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "10882101", "url": "https://glygen.org/publication/PubMed/10882101" } ] }, { "title": "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.", "journal": "Oncogene", "date": "2000", "authors": "Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, Benfield P, Brizuela L, Rolfe M", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "10918611", "url": "https://glygen.org/publication/PubMed/10918611" } ] }, { "title": "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain.", "journal": "Cell", "date": "2000", "authors": "Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-937072", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-937072" } ], "reference": [ { "type": "PubMed", "id": "11057907", "url": "https://glygen.org/publication/PubMed/11057907" } ] }, { "title": "Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G", "evidence": [ { "database": "Reactome", "id": "R-HSA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-168638" } ], "reference": [ { "type": "PubMed", "id": "11087742", "url": "https://glygen.org/publication/PubMed/11087742" } ] }, { "title": "Physiologic role of interleukin-1 receptor antagonist.", "journal": "Arthritis research", "date": "2000", "authors": "Arend WP, Gabay C", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "11094434", "url": "https://glygen.org/publication/PubMed/11094434" } ] }, { "title": "An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, Ninomiya-Tsuji J, Tsuchiya M, Matsumoto K", "evidence": [ { "database": "Reactome", "id": "R-HSA-937042", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-937042" } ], "reference": [ { "type": "PubMed", "id": "11323434", "url": "https://glygen.org/publication/PubMed/11323434" } ] }, { "title": "TAK1 is a ubiquitin-dependent kinase of MKK and IKK.", "journal": "Nature", "date": "2001", "authors": "Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-168638" } ], "reference": [ { "type": "PubMed", "id": "11460167", "url": "https://glygen.org/publication/PubMed/11460167" } ] }, { "title": "Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.", "journal": "Nature", "date": "2001", "authors": "Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "11544529", "url": "https://glygen.org/publication/PubMed/11544529" } ] }, { "title": "IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002", "authors": "Li S, Strelow A, Fontana EJ, Wesche H", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "11960013", "url": "https://glygen.org/publication/PubMed/11960013" } ] }, { "title": "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9705671", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9705671" } ], "reference": [ { "type": "PubMed", "id": "12019269", "url": "https://glygen.org/publication/PubMed/12019269" } ] }, { "title": "Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Ross K, Yang L, Dower S, Volpe F, Guesdon F", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12138165", "url": "https://glygen.org/publication/PubMed/12138165" } ] }, { "title": "Distinct molecular mechanism for initiating TRAF6 signalling.", "journal": "Nature", "date": "2002", "authors": "Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12140561", "url": "https://glygen.org/publication/PubMed/12140561" } ] }, { "title": "Structure of mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 suggests a bifunctional switch that couples kinase activation with nuclear export.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Meng W, Swenson LL, Fitzgibbon MJ, Hayakawa K, Ter Haar E, Behrens AE, Fulghum JR, Lippke JA", "evidence": [ { "database": "Reactome", "id": "R-HSA-450302", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-450302" } ], "reference": [ { "type": "PubMed", "id": "12171911", "url": "https://glygen.org/publication/PubMed/12171911" } ] }, { "title": "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-937072", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-937072" } ], "reference": [ { "type": "PubMed", "id": "12242293", "url": "https://glygen.org/publication/PubMed/12242293" } ] }, { "title": "IRAK-4 as the central TIR signaling mediator in innate immunity.", "journal": "Trends in immunology", "date": "2002", "authors": "Suzuki N, Suzuki S, Yeh WC", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12297423", "url": "https://glygen.org/publication/PubMed/12297423" } ] }, { "title": "Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.", "journal": "Nature", "date": "2002", "authors": "Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12447441", "url": "https://glygen.org/publication/PubMed/12447441" } ] }, { "title": "The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.", "journal": "Nature", "date": "2002", "authors": "Horng T, Barton GM, Flavell RA, Medzhitov R", "evidence": [ { "database": "Reactome", "id": "R-HSA-166058", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-166058" } ], "reference": [ { "type": "PubMed", "id": "12447442", "url": "https://glygen.org/publication/PubMed/12447442" } ] }, { "title": "Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Jiang Z, Johnson HJ, Nie H, Qin J, Bird TA, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "12496252", "url": "https://glygen.org/publication/PubMed/12496252" } ] }, { "title": "Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nunez G", "evidence": [ { "database": "Reactome", "id": "R-HSA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-168638" } ], "reference": [ { "type": "PubMed", "id": "12514169", "url": "https://glygen.org/publication/PubMed/12514169" } ] }, { "title": "Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-168638", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-168638" } ], "reference": [ { "type": "PubMed", "id": "12527755", "url": "https://glygen.org/publication/PubMed/12527755" } ] }, { "title": "Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4.", "journal": "The Journal of experimental medicine", "date": "2003", "authors": "Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R, Tschopp J", "evidence": [ { "database": "Reactome", "id": "R-HSA-9020702", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9020702" } ], "reference": [ { "type": "PubMed", "id": "12538665", "url": "https://glygen.org/publication/PubMed/12538665" } ] }, { "title": "Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .", "journal": "The Journal of biological chemistry", "date": "2003", "authors": "Jiang Z, Zamanian-Daryoush M, Nie H, Silva 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