{ "uniprot_canonical_ac": "O43155-1", "uniprot_ac": "O43155", "uniprot_id": "FLRT2_HUMAN", "mass": { "chemical_mass": 74049.0, "monoisotopic_mass": 74049.0 }, "refseq": { "ac": "NP_001333072", "name": "leucine-rich repeat transmembrane protein FLRT2 precursor", "summary": "This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" }, "gene_names": [ { "name": "FLRT2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O43155", "id": "O43155" }, { "name": "FLRT2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072", "id": "NP_001333072" }, { "name": "KIAA0405", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43155", "id": "O43155" }, { "name": "PRO265", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O43155", "id": "O43155" } ], "protein_names": [ { "name": "Leucine-rich repeat transmembrane protein FLRT2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O43155" }, { "name": "Fibronectin-like domain-containing leucine-rich transmembrane protein 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O43155" }, { "name": "leucine-rich repeat transmembrane protein FLRT2 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072", "id": "NP_001333072" }, { "name": "leucine-rich repeat transmembrane protein FLRT2; fibronectin-like domain-containing leucine-rich transmembrane protein 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072", "id": "NP_001333072" } ], "function": [ { "annotation": "Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155#function" }, { "database": "UniProtKB", "id": "Q8BLU0", "url": "https://www.uniprot.org/uniprot/Q8BLU0#function" } ] }, { "annotation": "OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci", "evidence": [ { "database": "RefSeq", "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" }, { "database": "PubMed", "id": "26890304", "url": "https://glygen.org/publication/PubMed/26890304" } ] }, { "annotation": "Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "database": "RefSeq", "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" }, { "database": "PubMed", "id": "19834535", "url": "https://glygen.org/publication/PubMed/19834535" } ] }, { "annotation": "Taken together, these results provide insights into the role of FLRT2 as a novel tumor suppressor in the breast, which is inactivated by hypermethylation during tumor development. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" }, { "database": "PubMed", "id": "28325946", "url": "https://glygen.org/publication/PubMed/28325946" } ] }, { "annotation": "This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016].", "evidence": [ { "database": "RefSeq", "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs892978595", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs892978595" }, { "id": "rs892978595", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs892978595#frequency_tab" }, { "id": "rs892978595", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs892978595" } ], "glycoeffect": [ "n-glyco-sequon-gain", "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 523, "end_pos": 523, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SNT->NNT); n-glyco-sequon-loss (NGS->NGN).", "chr_id": "14", "chr_pos": "85623082", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S523", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs865947851", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs865947851" }, { "id": "rs865947851", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs865947851" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 202, "end_pos": 202, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->SLT).", "chr_id": "14", "chr_pos": "85622119", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N202", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1304281167", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1304281167" }, { "id": "rs1304281167", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1304281167" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 204, "end_pos": 204, "sequence_org": "T", "sequence_mut": "M", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLT->NLM).", "chr_id": "14", "chr_pos": "85622125", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T204", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs529248853", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs529248853" }, { "id": "rs529248853", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs529248853" }, { "id": "rs529248853", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs529248853" }, { "id": "rs529248853", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs529248853" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 228, "end_pos": 228, "sequence_org": "H", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HLT->NLT).", "chr_id": "14", "chr_pos": "85622196", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "H228", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1400862891", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1400862891" }, { "id": "rs1400862891", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1400862891#frequency_tab" }, { "id": "rs1400862891", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1400862891" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 282, "end_pos": 282, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DIS->NIS).", "chr_id": "14", "chr_pos": "85622358", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D282", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1406569644", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1406569644" }, { "id": "rs1406569644", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1406569644" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 298, "end_pos": 298, "sequence_org": "N", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NLS->TLS).", "chr_id": "14", "chr_pos": "85622407", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N298", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1457412792", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1457412792" }, { "id": "rs1457412792", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1457412792" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 385, "end_pos": 385, "sequence_org": "T", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (TLS->NLS).", "chr_id": "14", "chr_pos": "85622668", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T385", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs201580499", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201580499" }, { "id": "rs201580499", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs201580499" }, { "id": "rs201580499", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201580499" }, { "id": "rs201580499", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201580499" }, { "id": "rs201580499", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs201580499#frequency_tab" }, { "id": "rs201580499", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs201580499" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 392, "end_pos": 392, "sequence_org": "S", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SRS->NRS).", "chr_id": "14", "chr_pos": "85622689", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000399", "site_lbl": "S392", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1158524247", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1158524247" }, { "id": "rs1158524247", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1158524247" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 407, "end_pos": 407, "sequence_org": "T", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->A).", "chr_id": "14", "chr_pos": "85622733", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T407", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs149180602", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149180602" }, { "id": "rs149180602", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs149180602" }, { "id": "rs149180602", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs149180602" }, { "id": "rs149180602", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs149180602#frequency_tab" }, { "id": "rs149180602", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs149180602" } ], "glycoeffect": [ "o-glyco-site-loss" ], "start_pos": 407, "end_pos": 407, "sequence_org": "T", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: o-glyco-site-loss (T->K).", "chr_id": "14", "chr_pos": "85622734", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.0002", "site_lbl": "T407", "keywords": [ "ebi", "germline" ] }, { 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"evidence": [ { "id": "rs1485467867", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1485467867" }, { "id": "rs1485467867", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1485467867" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 433, "end_pos": 433, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NDT->SDT).", "chr_id": "14", "chr_pos": "85622812", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N433", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs976793534", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs976793534" }, { "id": "rs976793534", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs976793534" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 522, "end_pos": 522, "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNG->NNS).", "chr_id": "14", "chr_pos": "85623078", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G522", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs759964695", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759964695" }, { "id": "rs759964695", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs759964695" }, { "id": "rs759964695", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs759964695" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 523, "end_pos": 523, "sequence_org": "S", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGS->NGR).", "chr_id": "14", "chr_pos": "85623083", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S523", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs182653425", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs182653425" }, { "id": "rs182653425", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs182653425" }, { "id": "rs182653425", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs182653425" }, { "id": "rs182653425", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs182653425#frequency_tab" }, { "id": "rs182653425", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs182653425" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 526, "end_pos": 526, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NTA->NTT).", "chr_id": "14", "chr_pos": "85623090", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.000399", "site_lbl": "A526", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1273708048", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1273708048" }, { "id": "rs1273708048", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1273708048" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 582, "end_pos": 582, "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NRG->NRS).", "chr_id": "14", "chr_pos": "85623258", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G582", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "74.14", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000185070", "url": 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"score": "83.45", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185070" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "88.16", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185070" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "81.22", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000185070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185070" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "74.8", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000185070", "url": 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"https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O43155", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43155" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43155" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"http://disease-ontology.org/term/DOID:3571", "name": "non-resectable primary hepatic malignant neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary liver cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "primary malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "resectable malignant neoplasm of the liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, not specified as primary or secondary", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Uterine cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:363", 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "common_name": "Human" } ], "gene": [ { "name": "FLRT2", "url": "https://www.uniprot.org/uniprot/O43155", "locus": { "chromosome": "14", "start_pos": 85654428, "end_pos": 85530144, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000185070", "url": "https://www.ensembl.org/id/ENSG00000185070" } ] } } ], "crossref": [ { "id": "ENSG00000185070", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000185070", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "FLRT2", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=FLRT2", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "23768", "url": "https://www.ncbi.nlm.nih.gov/gene/23768", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "3761", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3761", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O43155", "url": "https://www.ebi.ac.uk/intact/interactors/id:O43155*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000372", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000372", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR000483", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001611", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003591", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003961", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003961", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR032675", "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036116", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036116", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:23768", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23768", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "604807", "url": "http://www.omim.org/entry/604807", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O43155", "url": "https://www.nextprot.org/entry/NX_O43155", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O43155", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43155", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "KADFRIQ", "url": "https://omabrowser.org/oma/group/KADFRIQ/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "2916435at2759", "url": "http://www.orthodb.org/?query=2916435at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR45712:SF16", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45712:SF16", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00041", "url": "http://pfam.xfam.org/family/PF00041", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01462", "url": "http://pfam.xfam.org/family/PF01462", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01463", "url": "http://pfam.xfam.org/family/PF01463", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13855", "url": "http://pfam.xfam.org/family/PF13855", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O43155", "url": "https://pharos.nih.gov/targets/O43155", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR:000050726", "url": "https://proconsortium.org/app/entry/PR:000050726", "database": "PRO", "categories": [ "Glycoproteomics" ] }, { "id": "PR_O43155", "url": "http://purl.obolibrary.org/obo/PR_O43155", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-5654687", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654687", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O43155", "url": "DISABLED", "database": "UniCarbKB", "categories": [ "Glycoproteomics" ] }, { "id": "A0A804HKH2", "url": "https://www.uniprot.org/uniprot/A0A804HKH2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A804HKH2-1", "url": "https://www.uniprot.org/uniprot/A0A804HKH2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43155-1", "url": "https://www.uniprot.org/uniprot/O43155-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT", "length": 660, "header": "sp|O43155-1|FLRT2_HUMAN Isoform 1 of Leucine-rich repeat transmembrane protein FLRT2 OS=Homo sapiens OX=9606 GN=FLRT2 PE=1 SV=1 CANONICAL=O43155-1" }, "isoforms": [ { "isoform_ac": "A0A804HKH2-1", "url": "", "sequence": { "sequence": "MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQ", "length": 183, "header": "tr|A0A804HKH2-1|FLRT2_HUMAN Computationally mapped isoform of Leucine-rich repeat transmembrane protein FLRT2 OS=Homo sapiens OX=9606 GN=FLRT2 PE=1 SV=1 CANONICAL=O43155-1" }, "locus": { "chromosome": "14", "start_pos": 85622063, "end_pos": 85621515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000684303.1", "url": "https://www.ensembl.org/id/ENST00000684303.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000507928.1", "url": "https://www.ensembl.org/id/ENSP00000507928.1" } ] } }, { "isoform_ac": "O43155-1", "url": "", "sequence": { "sequence": "MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT", "length": 660, "header": "sp|O43155-1|FLRT2_HUMAN Isoform 1 of Leucine-rich repeat transmembrane protein FLRT2 OS=Homo sapiens OX=9606 GN=FLRT2 PE=1 SV=1 CANONICAL=O43155-1" }, "locus": { "chromosome": "14", "start_pos": 85623494, "end_pos": 85621515, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000330753.6", "url": "https://www.ensembl.org/id/ENST00000330753.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000332879.4", "url": "https://www.ensembl.org/id/ENSP00000332879.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 202, "start_aa": "Asn", "end_pos": 202, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn202", "evidence": [ { "id": "O43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43155#ptm_processing" }, { "id": "19159218", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/19159218" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 298, "start_aa": "Asn", "end_pos": 298, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn298", "evidence": [ { "id": "O43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43155#ptm_processing" } ] }, { "glytoucan_ac": "G43417UB", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "", "start_pos": 407, "start_aa": "Thr", "end_pos": 407, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr407", "evidence": [ { "id": "O43155", "database": "UniCarbKB", "url": "" }, { "id": "30459171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 433, "start_aa": "Asn", "end_pos": 433, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn433", "evidence": [ { "id": "O43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43155#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 521, "start_aa": "Asn", "end_pos": 521, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn521", "evidence": [ { "id": "O43155", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43155#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O43155", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43155" }, { "id": "34019948", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_reported", "glycoprotein_predicted" ], "publication": [ { "title": "Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.", "journal": "Genomics", "date": "1999", "authors": "Lacy SE, Bonnemann CG, Buzney EA, Kunkel LM", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "reference": [ { "type": "PubMed", "id": "10644439", "url": "https://glygen.org/publication/PubMed/10644439" } ] }, { "title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.", "journal": "Genome Res.", "date": "2003", "authors": "Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "reference": [ { "type": "PubMed", "id": "12975309", "url": "https://glygen.org/publication/PubMed/12975309" } ] }, { "title": "The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling.", "journal": "Nature cell biology", "date": "2004", "authors": "Bottcher RT, Pollet N, Delius H, Niehrs C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5654687", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654687" } ], "reference": [ { "type": "PubMed", "id": "14688794", "url": "https://glygen.org/publication/PubMed/14688794" } ] }, { "title": "Signal peptide prediction based on analysis of experimentally verified cleavage sites.", "journal": "Protein Sci.", "date": "2004", "authors": "Zhang Z, Henzel WJ", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "reference": [ { "type": "PubMed", "id": "15340161", "url": "https://glygen.org/publication/PubMed/15340161" } ] }, { "title": "Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development.", "journal": "Developmental biology", "date": "2006", "authors": "Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW", "evidence": [ { "database": "Reactome", "id": "R-HSA-5654687", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654687" } ], "reference": [ { "type": "PubMed", "id": "16872596", "url": "https://glygen.org/publication/PubMed/16872596" } ] }, { "title": "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.", "journal": "Journal of proteome research", "date": "2009", "authors": "Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155#ptm_processing" }, { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "reference": [ { "type": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" } ] }, { "title": "Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.", "journal": "PLoS genetics", "date": "2009", "authors": "Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK", "evidence": [ { "database": "RefSeq", "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" } ], "reference": [ { "type": "PubMed", "id": "19834535", "url": "https://glygen.org/publication/PubMed/19834535" } ] }, { "title": "Critical role of FLRT1 phosphorylation in the interdependent regulation of FLRT1 function and FGF receptor signalling.", "journal": "PloS one", "date": "2010", "authors": "Wheldon LM, Haines BP, Rajappa R, Mason I, Rigby PW, Heath JK", "evidence": [ { "database": "Reactome", "id": "R-HSA-5654687", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654687" } ], "reference": [ { "type": "PubMed", "id": "20421966", "url": "https://glygen.org/publication/PubMed/20421966" } ] }, { "title": "Methylation profiling identified novel differentially methylated markers including OPCML and FLRT2 in prostate cancer.", "journal": "Epigenetics", "date": "2016", "authors": "Wu Y, Davison J, Qu X, Morrissey C, Storer B, Brown L, Vessella R, Nelson P, Fang M", "evidence": [ { "database": "RefSeq", "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" } ], "reference": [ { "type": "PubMed", "id": "26890304", "url": "https://glygen.org/publication/PubMed/26890304" } ] }, { "title": "Epigenetically regulated Fibronectin leucine rich transmembrane protein 2 (FLRT2) shows tumor suppressor activity in breast cancer cells.", "journal": "Scientific reports", "date": "2017", "authors": "Bae H, Kim B, Lee H, Lee S, Kang HS, Kim SJ", "evidence": [ { "database": "RefSeq", "id": "NP_001333072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072" } ], "reference": [ { "type": "PubMed", "id": "28325946", "url": "https://glygen.org/publication/PubMed/28325946" } ] }, { "title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).", "journal": "Molecular systems biology", "date": "2018", "authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H", "evidence": [ { "database": "UniCarbKB", "id": "O43155", "url": "" } ], "reference": [ { "type": "PubMed", "id": "30459171", "url": "https://glygen.org/publication/PubMed/30459171" } ] }, { "title": "O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.", "journal": "Biochimica et biophysica acta. General subjects", "date": "2021", "authors": "Xie X, Wu Q, Zhang K, Liu Y, Zhang N, Chen Q, Wang L, Li W, Zhang J, Liu Y", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43155", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43155" } ], "reference": [ { "type": "PubMed", "id": "34019948", "url": "https://glygen.org/publication/PubMed/34019948" } ] } ], "pathway": [ { "id": "hsa:23768", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:23768", "resource": "KEGG Pathway" }, { "id": "R-HSA-5654687", "name": "Downstream signaling of activated FGFR1", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5654687", "resource": "Reactome", "description": "Downstream signaling of activated FGFR1" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZTV3-1", "protein_name": "Leucine-rich repeat transmembrane protein FLRT2", "gene_name": "Flrt2", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MGLQTAKWPSHGTFVLKFWLIMSLGLYSHVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIADGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTVSVPSPSRGSVPPAPAPSKLPTIPDWDGRERATPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTICSEATTHASYLNNGSNTASSHEQTTSHTMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT", "length": 660 }, "evidence": [ { "id": "45923564", "url": "http://www.informatics.jax.org/homology/45923564", "database": "MGI" }, { "id": "O43155", "url": "https://omabrowser.org/oma/group/O43155/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BLU0-1", "protein_name": "Leucine-rich repeat transmembrane protein FLRT2", "gene_name": "Flrt2", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MGLQTTKWPGRGAFILKFWLIISLGLYLQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTLSVPSPSRGSVPPAPTPSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT", "length": 660 }, "evidence": [ { "id": "45923564", "url": "http://www.informatics.jax.org/homology/45923564", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 9, "go_terms": [ { "name": "extracellular space", "id": "GO:0005615", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "cell-cell junction", "id": "GO:0005911", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "endoplasmic reticulum membrane", "id": "GO:0005789", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "neuron projection", "id": "GO:0043005", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "protein-macromolecule adaptor activity", "id": "GO:0030674", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "chemorepellent activity", "id": "GO:0045499", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045499", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor binding", "id": "GO:0005104", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005104", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 7, "go_terms": [ { "name": "heart morphogenesis", "id": "GO:0003007", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003007", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "positive regulation of synapse assembly", "id": "GO:0051965", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051965", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "regulation of neuron migration", "id": "GO:2001222", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001222", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "fibroblast growth factor receptor signaling pathway", "id": "GO:0008543", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008543", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "basement membrane organization", "id": "GO:0071711", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071711", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" }, { "name": "cell adhesion involved in heart morphogenesis", "id": "GO:0061343", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061343", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" } ], "pmid": "" } ] } ] }, "pro_annotation": [ { "name": "leucine-rich repeat transmembrane protein FLRT2 O-glycosylated 1 (human)", "definition": "A leucine-rich repeat transmembrane protein FLRT2 (human) that has been O-glycosylated at the residue equivalent to Thr-407 of the amino acid sequence represented by UniProtKB:O43155-1, in which the glycan composition is represented by GlyTouCan:G43417UB. Example: UniProtKB:O43155-1, Thr-407, MOD:00005~GNO:G43417UB. [PRO:DNx, PMID:30459171]", "evidence": [ { "id": "PR:000050726", "database": "PRO", "url": "https://proconsortium.org/app/entry/PR:000050726" } ] } ], "site_annotation": [ { "start_pos": 202, "end_pos": 204, "annotation": "n_glycosylation_sequon" }, { "start_pos": 298, "end_pos": 300, "annotation": "n_glycosylation_sequon" }, { "start_pos": 433, "end_pos": 435, "annotation": "n_glycosylation_sequon" }, { "start_pos": 521, "end_pos": 523, "annotation": "n_glycosylation_sequon" }, { "start_pos": 635, "end_pos": 637, "annotation": "n_glycosylation_sequon" }, { "start_pos": 649, "end_pos": 651, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "N-glycosylated.", "evidence": [ { "database": "UniProtKB", "id": "O43155", "url": "https://www.uniprot.org/uniprot/O43155" }, { "database": "PubMed", "id": "10644439", "url": "https://glygen.org/publication/PubMed/10644439" }, { "database": "PubMed", "id": "19159218", "url": "https://glygen.org/publication/PubMed/19159218" } ] } ], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 202, 298, 433, 521 ], "o_linked_sites": [ 407 ], "snv_sites": [ 202, 204, 228, 282, 298, 385, 392, 407, 433, 522, 523, 526, 582 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 202, "end_pos": 204 }, { "start_pos": 298, "end_pos": 300 }, { "start_pos": 433, "end_pos": 435 }, { "start_pos": 521, "end_pos": 523 }, { "start_pos": 635, "end_pos": 637 }, { "start_pos": 649, "end_pos": 651 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 2 }, { "field": "o_linked_glycan_sites", "count": 2 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 3 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", 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