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disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O43151", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Urinary bladder cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11054", "evidence": [ { "database": "BioXpress", "id": "O43151", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:11054", "recommended_name": { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "urinary bladder cancer", "description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "cancer of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant urinary bladder tumour", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant neoplasm", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumor", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder malignant tumour", "description": "" }, { "id": "MIM:109800", "resource": "MIM", "url": "https://www.omim.org/entry/109800", "name": "Bladder cancer", "description": "Bladder cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Head and neck cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:11934", "evidence": [ { "database": "BioXpress", "id": "O43151", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:11934", "recommended_name": { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck cancer", "description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx." }, "synonyms": [ { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head and neck tumours", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "head/neck neoplasm", "description": "" }, { "id": "DOID:11934", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11934", "name": "tumor of head and neck", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Lung cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1324", "evidence": [ { "database": "BioXpress", "id": "O43151", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine 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"id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine 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"MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Breast cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1612", "evidence": [ { "database": "BioXpress", "id": "O43151", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O43151", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O43151", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O43151" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", 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located_in the esophagus." }, "synonyms": [ { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca lower third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "Ca middle third oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "esophagus cancer", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of distal third of esophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:5041", "name": "malignant neoplasm of lower third of oesophagus", "description": "" }, { "id": "DOID:5041", "resource": "Disease Ontology", "url": 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Classification" ] }, { "id": "NP_001274420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274420", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "52636", "url": "https://www.rhea-db.org/rhea/52636", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53828", "url": "https://www.rhea-db.org/rhea/53828", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53832", "url": "https://www.rhea-db.org/rhea/53832", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A5H1ZRP3", "url": "https://www.uniprot.org/uniprot/A0A5H1ZRP3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A5H1ZRP3-1", "url": "https://www.uniprot.org/uniprot/A0A5H1ZRP3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43151-1", "url": "https://www.uniprot.org/uniprot/O43151-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43151-2", "url": "https://www.uniprot.org/uniprot/O43151-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O43151-3", "url": "https://www.uniprot.org/uniprot/O43151-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MSQFQVPLAVQPDLPGLYDFPQRQVMVGSFPGSGLSMAGSESQLRGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGITSDPGLSLKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSYHSYYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPDLHALHNSLSPAYGGAEFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSVSRDPSPFAQSSNCYNRSIKQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHFTDGQWGLFPGEGQQAASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGFQDKLWNPMKGEEGRIPAAGASQLDRAWQSFGLPLGSSEKLFGALKSEEKLWDPFSLEEGPAEEPPSKGAVKEEKGGGGAEEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGQQEAKLYGKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1795, "header": "sp|O43151-1|TET3_HUMAN Isoform 1 of Methylcytosine dioxygenase TET3 OS=Homo sapiens OX=9606 GN=TET3 PE=1 SV=4 CANONICAL=O43151-1" }, "isoforms": [ { "isoform_ac": "A0A5H1ZRP3-1", "url": "", "sequence": { "sequence": "MHQRRPAEVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGITSDPGLSLKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSYHSYYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPDLHALHNSLSPAYGGAEFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSVSRDPSPFAQSSNCYNRSIKQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHFTDGQWGLFPGEGQQAASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGFQDKLWNPMKGEEGRIPAAGASQLDRAWQSFGLPLGSSEKLFGALKSEEKLWDPFSLEEGPAEEPPSKGAVKEEKGGGGAEEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGQQEAKLYGKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1702, "header": "tr|A0A5H1ZRP3-1|TET3_HUMAN Computationally mapped isoform of Methylcytosine dioxygenase TET3 OS=Homo sapiens OX=9606 GN=TET3 PE=1 SV=1 CANONICAL=O43151-1" }, "locus": { "chromosome": "2", "start_pos": 74102173, "end_pos": 74002778, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000305799.8", "url": "https://www.ensembl.org/id/ENST00000305799.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000307803.8", "url": "https://www.ensembl.org/id/ENSP00000307803.8" } ] } }, { "isoform_ac": "O43151-1", "url": "", "sequence": { "sequence": "MSQFQVPLAVQPDLPGLYDFPQRQVMVGSFPGSGLSMAGSESQLRGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGITSDPGLSLKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSYHSYYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPDLHALHNSLSPAYGGAEFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSVSRDPSPFAQSSNCYNRSIKQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHFTDGQWGLFPGEGQQAASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGFQDKLWNPMKGEEGRIPAAGASQLDRAWQSFGLPLGSSEKLFGALKSEEKLWDPFSLEEGPAEEPPSKGAVKEEKGGGGAEEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGQQEAKLYGKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1795, "header": "sp|O43151-1|TET3_HUMAN Isoform 1 of Methylcytosine dioxygenase TET3 OS=Homo sapiens OX=9606 GN=TET3 PE=1 SV=4 CANONICAL=O43151-1" }, "locus": { "chromosome": "2", "start_pos": 74102173, "end_pos": 73986404, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000409262.8", "url": "https://www.ensembl.org/id/ENST00000409262.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000386869.3", "url": "https://www.ensembl.org/id/ENSP00000386869.3" } ] } }, { "isoform_ac": "O43151-2", "url": "", "sequence": { "sequence": "MSQFQVPLAVQPDLPGLYDFPQRQVMVGSFPGSGLSMAGSESQLRGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKSFQDLATEVAPLYKRLAPQAYQNQVTNEEIAIDCRLGLKEGRPFAGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGKIPEDEQLHVLPLYKMANTDEFGSEENQNAKVGSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGITSDPGLSLKGGLSQQGLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGNCRPSDPYSMNSVYSYHSYYAQPSLTSVNGFHSKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHSGSSGSFEKKPDLHALHNSLSPAYGGAEFAELPSQAVPTDAHHPTPHHQQPAYPGPKEYLLPKAPLLHSVSRDPSPFAQSSNCYNRSIKQEPVDPLTQAEPVPRDAGKMGKTPLSEVSQNGGPSHLWGQYSGGPSMSPKRTNGVGGSWGVFSSGESPAIVPDKLSSFGASCLAPSHFTDGQWGLFPGEGQQAASHSGGRLRGKPWSPCKFGNSTSALAGPSLTEKPWALGAGDFNSALKGSPGFQDKLWNPMKGEEGRIPAAGASQLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGQQEAKLYGKKRKWGGTVVAEPQQKEKKGVVPTRQALAVPTDSAVTVSSYAYTKVTGPYSRWI", "length": 1679, "header": "sp|O43151-2|TET3_HUMAN Isoform 2 of Methylcytosine dioxygenase TET3 OS=Homo sapiens OX=9606 GN=TET3 PE=1 SV=4 CANONICAL=O43151-1" }, "locus": {} }, { "isoform_ac": "O43151-3", "url": "", "sequence": { "sequence": "MSQFQVPLAVQPDLPGLYDFPQRQVMVGSFPGSGLSMAGSESQLRGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEVLKKKVGLLKEVEIKAGEGAGPWGQGAAVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSASGVPVNGAREPAGPSLLGTGGPWRVDQKPDWEAAPGPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNSRGPRPGPEGCSAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGEERPRLPGPLPPGEAGLPAPSTRPLLSSEVPQISPQEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTPQASCPLPEALSPPAPFRSPQSYLRAPSWPVVPPEEHSSFAPDSSAFPPATPRTEFPEAWGTDTPPATPRSSWPMPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPAPSPVLQREAPTPSSEPDTHQKAQTALQQHLHHKRSLFLEQVHDTSFPAPSEPSAPGWWPPPSSPVPRLPDRPPKEKKKKLPTPAGGPVGTEKAAPGIKPSVRKPIQIKKSRPREAQPLFPPVRQIVLEGLRSPASQEVQAHPPAPLPASQGSAVPLPPEPSLALFAPSPSRDSLLPPTQEMRSPSPMTALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDPENQQTCLPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEER", "length": 862, "header": "sp|O43151-3|TET3_HUMAN Isoform 3 of Methylcytosine dioxygenase TET3 OS=Homo sapiens OX=9606 GN=TET3 PE=1 SV=4 CANONICAL=O43151-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1210, "start_aa": "Ser", "end_pos": 1210, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1210", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43151" }, { "id": "24304661", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24304661" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1270, "start_aa": "Thr", "end_pos": 1270, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1270", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43151" }, { "id": "32938750", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1379, "start_aa": "Ser", "end_pos": 1379, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1379", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "30620550", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30620550" }, { "id": "24394411", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24394411" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "24304661", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24304661" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1405, "start_aa": "Thr", "end_pos": 1405, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr1405", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43151" }, { "id": "24304661", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24304661" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 1439, "start_aa": "Ser", "end_pos": 1439, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser1439", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43151" }, { "id": "24304661", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24304661" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 152, "start_aa": "Ser", "end_pos": 152, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser152", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43151" }, { "id": "24304661", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24304661" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "S", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 381, "start_aa": "Ser", "end_pos": 381, "end_aa": "Ser", "residue": "Ser", "site_lbl": "Ser381", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" }, { "id": "37340703", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37340703" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "38253038", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/38253038" }, { "id": "30620550", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30620550" }, { "id": "24394411", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24394411" }, { "id": "35132862", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35132862" }, { "id": "24304661", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24304661" }, { "id": "35254053", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35254053" }, { "id": "35289036", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/35289036" }, { "id": "O43151", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O43151" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 431, "start_aa": "Thr", "end_pos": 431, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr431", "evidence": [ { "id": "O43151", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" }, { 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histone H3 lysine 4 demethylases.", "journal": "Cell", "date": "2007", "authors": "Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-9821002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821002" } ], "reference": [ { "type": "PubMed", "id": "17320160", "url": "https://glygen.org/publication/PubMed/17320160" } ] }, { "title": "RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.", "journal": "Cell", "date": "2007-03-23", "authors": "Christensen Jesper, Agger Karl, Cloos Paul A C, Pasini Diego, Rose Simon, Sennels Lau, Rappsilber Juri, Hansen Klaus H, Salcini Anna Elisabetta, Helin Kristian", "evidence": [ { "database": "Reactome", "id": "R-HSA-9821002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821002" } ], "reference": [ { "type": "PubMed", "id": "17320161", "url": 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Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL", "evidence": [ { "database": "RefSeq", "id": "NP_001274420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274420" } ], "reference": [ { "type": "PubMed", "id": "19420352", "url": "https://glygen.org/publication/PubMed/19420352" } ] }, { "title": "TET proteins in malignant hematopoiesis.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2009", "authors": "Langemeijer SM, Aslanyan MG, Jansen JH", "evidence": [ { "database": "RefSeq", "id": "NP_001274420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274420" } ], "reference": [ { "type": "PubMed", "id": "19923888", "url": "https://glygen.org/publication/PubMed/19923888" } ] }, { "title": "Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.", "journal": "Nature", "date": "2010", "authors": "Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "20639862", "url": "https://glygen.org/publication/PubMed/20639862" } ] }, { "title": "Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.", "journal": "Nature", "date": "2010", "authors": "Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Ganetzky R, Liu XS, Aravind L, Agarwal S, Maciejewski JP, Rao A", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "21057493", "url": "https://glygen.org/publication/PubMed/21057493" } ] }, { "title": "Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2011", "authors": "Iqbal K, Jin SG, Pfeifer GP, Szabo PE", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "21321204", "url": "https://glygen.org/publication/PubMed/21321204" } ] }, { "title": "Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.", "journal": "Cell", "date": "2011", "authors": "Guo JU, Su Y, Zhong C, Ming GL, Song H", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "21496894", "url": "https://glygen.org/publication/PubMed/21496894" } ] }, { "title": "Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.", "journal": "Science (New York, N.Y.)", "date": "2011", "authors": "He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L, Sun Y, Li X, Dai Q, Song CX, Zhang K, He C, Xu GL", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "21817016", "url": "https://glygen.org/publication/PubMed/21817016" } ] }, { "title": "Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Maiti A, Drohat AC", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "21862836", "url": "https://glygen.org/publication/PubMed/21862836" } ] }, { "title": "Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.", "journal": "Nature chemical biology", "date": "2012", "authors": "Zhang L, Lu X, Lu J, Liang H, Dai Q, Xu GL, Luo C, Jiang H, He C", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "22327402", "url": "https://glygen.org/publication/PubMed/22327402" } ] }, { "title": "Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor.", "journal": "The FEBS journal", "date": "2012-06", "authors": "Kristensen Line H, Nielsen Anders L, Helgstrand Charlotte, Lees Michael, Cloos Paul, Kastrup Jette S, Helin Kristian, Olsen Lars, Gajhede Michael", "evidence": [ { "database": "Reactome", "id": "R-HSA-9821002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821002" } ], "reference": [ { "type": "PubMed", "id": "22420752", "url": "https://glygen.org/publication/PubMed/22420752" } ] }, { "title": 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"https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "23217707", "url": "https://glygen.org/publication/PubMed/23217707" } ] }, { "title": "TET2 promotes histone O-GlcNAcylation during gene transcription.", "journal": "Nature", "date": "2013", "authors": "Chen Q, Chen Y, Bian C, Fujiki R, Yu X", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "23222540", "url": "https://glygen.org/publication/PubMed/23222540" } ] }, { "title": "TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.", "journal": "The EMBO journal", "date": "2013", "authors": "Deplus R, Delatte B, Schwinn MK, Defrance M, Mendez J, Murphy N, Dawson MA, Volkmar M, Putmans P, Calonne E, Shih AH, Levine RL, Bernard O, Mercher T, Solary E, Urh M, Daniels DL, Fuks F", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "23353889", "url": "https://glygen.org/publication/PubMed/23353889" } ] }, { "title": "Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis.", "journal": "Cell reports", "date": "2013", "authors": "Hahn MA, Qiu R, Wu X, Li AX, Zhang H, Wang J, Jui J, Jin SG, Jiang Y, Pfeifer GP, Lu Q", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "23403289", "url": "https://glygen.org/publication/PubMed/23403289" } ] }, { "title": "Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine.", "journal": "The Journal of biological chemistry", "date": "2013", "authors": "Minor EA, Court BL, Young JI, Wang G", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "23548903", "url": "https://glygen.org/publication/PubMed/23548903" } ] }, { "title": "A mechanistic overview of TET-mediated 5-methylcytosine oxidation.", "journal": "Biochemical and biophysical research communications", "date": "2013", "authors": "Ponnaluri VK, Maciejewski JP, Mukherji M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "23727577", "url": "https://glygen.org/publication/PubMed/23727577" } ] }, { "title": "Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.", "journal": "Nature", "date": "2013", "authors": "Blaschke K, Ebata KT, Karimi MM, Zepeda-Martinez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "23812591", "url": "https://glygen.org/publication/PubMed/23812591" } ] }, { "title": "TET3-OGT interaction increases the stability and the presence of OGT in chromatin.", "journal": "Genes to cells : devoted to molecular & cellular mechanisms", "date": "2014", "authors": "Ito R, Katsura S, Shimada H, Tsuchiya H, Hada M, Okumura T, Sugawara A, Yokoyama A", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" }, { "database": "O-GlcNAc Atlas", "id": "O43151", "url": "https://oglcnac.org/atlas/detail/O43151" } ], "reference": [ { "type": "PubMed", "id": "24304661", "url": "https://glygen.org/publication/PubMed/24304661" } ] }, { "title": "Crystal structure of TET2-DNA complex: insight into TET-mediated 5mC oxidation.", "journal": "Cell", "date": "2013", "authors": "Hu L, Li Z, Cheng J, Rao Q, Gong W, Liu M, Shi YG, Zhu J, Wang P, Xu Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-5221030", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030" } ], "reference": [ { "type": "PubMed", "id": "24315485", "url": "https://glygen.org/publication/PubMed/24315485" } ] }, { "title": "CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.", "journal": "Science", "date": "2013", "authors": "Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "24357321", "url": "https://glygen.org/publication/PubMed/24357321" } ] }, { "title": "Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked beta-N-acetylglucosamine transferase (OGT).", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Zhang Q, Liu X, Gao W, Li P, Hou J, Li J, Wong J", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" } ], "reference": [ { "type": "PubMed", "id": "24394411", "url": "https://glygen.org/publication/PubMed/24394411" } ] }, { "title": "Uncovering global SUMOylation signaling networks in a site-specific manner.", "journal": "Nat. 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Biol.", "date": "2014", "authors": "Hendriks IA, D'Souza RC, Yang B, Verlaan-de Vries M, Mann M, Vertegaal AC", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "25218447", "url": "https://glygen.org/publication/PubMed/25218447" } ] }, { "title": "CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.", "journal": "Molecular cell", "date": "2015", "authors": "Nakagawa T, Lv L, Nakagawa M, Yu Y, Yu C, D'Alessio AC, Nakayama K, Fan HY, Chen X, Xiong Y", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "25557551", "url": "https://glygen.org/publication/PubMed/25557551" } ] }, { "title": "DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.", "journal": "Structure (London, England : 1993)", "date": "2018", "authors": "Xu C, Liu K, Lei M, Yang A, Li Y, Hughes TR, Min J", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "29276034", "url": "https://glygen.org/publication/PubMed/29276034" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "An Isotope-Coded Photocleavable Probe for Quantitative Profiling of Protein O-GlcNAcylation.", "journal": "ACS chemical biology", "date": "2019", "authors": "Li J, Li Z, Duan X, Qin K, Dang L, Sun S, Cai L, Hsieh-Wilson LC, Wu L, Yi W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" }, { "database": "O-GlcNAc Atlas", "id": "O43151", "url": "https://oglcnac.org/atlas/detail/O43151" } ], "reference": [ { "type": "PubMed", "id": "30620550", "url": "https://glygen.org/publication/PubMed/30620550" } ] }, { "title": "Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency.", "journal": "American journal of human genetics", "date": "2020", "authors": "Beck DB, Petracovici A, He C, Moore HW, Louie RJ, Ansar M, Douzgou S, Sithambaram S, Cottrell T, Santos-Cortez RLP, Prijoles EJ, Bend R, Keren B, Mignot C, Nougues MC, Ounap K, Reimand T, Pajusalu S, Zahid M, Saqib MAN, Buratti J, Seaby EG, McWalter K, Telegrafi A, Baldridge D, Shinawi M, Leal SM, Schaefer GB, Stevenson RE, Banka S, Bonasio R, Fahrner JA", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "reference": [ { "type": "PubMed", "id": "31928709", "url": "https://glygen.org/publication/PubMed/31928709" } ] }, { "title": "Methods for Enrichment and Assignment of N-Acetylglucosamine Modification Sites.", "journal": "Molecular & cellular proteomics : MCP", "date": "2021", "authors": "Maynard JC, Chalkley RJ", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O43151", "url": "https://oglcnac.org/atlas/detail/O43151" } ], "reference": [ { "type": "PubMed", "id": "32938750", "url": "https://glygen.org/publication/PubMed/32938750" } ] }, { "title": "Highly Efficient Enrichment of O-GlcNAc Glycopeptides Based on Chemical Oxidation and Reversible Hydrazide Chemistry.", "journal": "Analytical chemistry", "date": "2021", "authors": "Chen Y, Qin H, Yue X, Zhou J, Liu L, Nie Y, Ye M", "evidence": [ { "database": "O-GlcNAc Atlas", "id": "O43151", "url": "https://oglcnac.org/atlas/detail/O43151" } ], "reference": [ { "type": "PubMed", "id": "34846842", "url": "https://glygen.org/publication/PubMed/34846842" } ] }, { "title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.", "journal": "Analytical chemistry", "date": "2022", "authors": "Xu S, Zheng J, Xiao H, Wu R", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" } ], "reference": [ { "type": "PubMed", "id": "35132862", "url": "https://glygen.org/publication/PubMed/35132862" } ] }, { "title": "An Optimized Isotopic Photocleavable Tagging Strategy for Site-Specific and Quantitative Profiling of Protein O-GlcNAcylation in Colorectal Cancer Metastasis.", "journal": "ACS chemical biology", "date": "2022", "authors": "Liu J, Hao Y, Wang C, Jin Y, Yang Y, Gu J, Chen X", "evidence": [ { "database": "O-GlcNAc Database", "id": 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Yang Yueli, Iba\u00f1ez David P, Lai Junjian, Wei Xiaoyu, An Juan, Guo Pengcheng, Yuan Yue, Deng Qiuting, Wang Yang, Liu Ying, Gao Fei, Wang Junwen, Zaman Shahriar, Qin Baoming, Wu Guangming, Maxwell Patrick H, Xu Xun, Liu Longqi, Li Wenjuan, Esteban Miguel A", "evidence": [ { "database": "Reactome", "id": "R-HSA-9821002", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821002" } ], "reference": [ { "type": "PubMed", "id": "35314832", "url": "https://glygen.org/publication/PubMed/35314832" } ] }, { "title": "Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency.", "journal": "Nature", "date": "2022", "authors": "Chen B, Du YR, Zhu H, Sun ML, Wang C, Cheng Y, Pang H, Ding G, Gao J, Tan Y, Tong X, Lv P, Zhou F, Zhan Q, Xu ZM, Wang L, Luo D, Ye Y, Jin L, Zhang S, Zhu Y, Lin X, Wu Y, Jin L, Zhou Y, Yan C, Sheng J, Flatt PR, Xu GL, Huang H", "evidence": [ { "database": "RefSeq", "id": "NP_001274420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274420" } ], 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Taylor HS, Liu ZW, Gao XB, Horvath TL, Huang Y", "evidence": [ { "database": "RefSeq", "id": "NP_001274420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274420" } ], "reference": [ { "type": "PubMed", "id": "36189793", "url": "https://glygen.org/publication/PubMed/36189793" } ] }, { "title": "DNMT3B attenuated the inhibition of TET3 on epithelial-mesenchymal transition in TGF-\u03b21-induced ovarian cancer by methylating the TET3 promoter.", "journal": "Reproductive biology", "date": "2022-12", "authors": "Ye Zhongxue, Jiang Yafen, Wu Junlong", "evidence": [ { "database": "RefSeq", "id": "NP_001274420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274420" } ], "reference": [ { "type": "PubMed", "id": "36242939", "url": "https://glygen.org/publication/PubMed/36242939" } ] }, { "title": "`Two Birds One Stone` Strategy for the Site-Specific Analysis of Core Fucosylation and O-GlcNAcylation.", "journal": "Journal of the American Chemical Society", "date": "2023-07-26", "authors": "Luo Yawen, Wang Yuqiu, Tian Yinping, Zhou Hu, Wen Liuqing", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" } ], "reference": [ { "type": "PubMed", "id": "37340703", "url": "https://glygen.org/publication/PubMed/37340703" } ] }, { "title": "The impact and mechanism of TET3 overexpression on the progression of hepatic fibrosis.", "journal": "Epigenomics", "date": "2023-05", "authors": "Liu Ranyang, Feng Linlin, Tang Shuang, Liu Yin, Yang Qin", "evidence": [ { "database": "RefSeq", "id": "NP_001274420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274420" } ], "reference": [ { "type": "PubMed", "id": "37464780", "url": "https://glygen.org/publication/PubMed/37464780" } ] }, { "title": "Studying the O-GlcNAcome of human placentas using banked tissue samples.", "journal": "Glycobiology", "date": "2024-01-22", "authors": "Luna Sarai, Malard Florian, Pereckas Michaela, Aoki Mayumi, Aoki Kazahiro, Olivier-Van Stichelen Stephanie", "evidence": [ { "database": "O-GlcNAc Database", "id": "O43151", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O43151" } ], "reference": [ { "type": "PubMed", "id": "38253038", "url": "https://glygen.org/publication/PubMed/38253038" } ] } ], "pathway": [ { "id": "hsa:200424", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:200424", "resource": "KEGG Pathway" }, { "id": "R-HSA-5221030", "name": "TET1,2,3 and TDG demethylate DNA", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221030", "resource": "Reactome", "description": "TET1,2,3 and TDG demethylate DNA" }, { "id": "R-HSA-9821002", "name": "Chromatin modifications during the maternal to zygotic transition (MZT)", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9821002", "resource": "Reactome", "description": "Chromatin modifications during the maternal to zygotic transition (MZT)" } ], "orthologs": [ { "uniprot_canonical_ac": 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"length": 1803 }, "evidence": [ { "id": "45927853", "url": "http://www.informatics.jax.org/homology/45927853", "database": "MGI" }, { "id": "O43151", "url": "https://omabrowser.org/oma/group/O43151/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "female pronucleus", "id": "GO:0001939", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001939", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "chromosome", "id": "GO:0005694", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005694", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "male pronucleus", "id": "GO:0001940", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001940", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "zinc ion binding", "id": "GO:0008270", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "methyl-CpG binding", "id": "GO:0008327", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008327", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "methylcytosine dioxygenase activity", "id": "GO:0070579", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070579", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 6, "go_terms": [ { "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "DNA demethylation", "id": "GO:0080111", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0080111", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "protein O-linked glycosylation", "id": "GO:0006493", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006493", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "epigenetic programing of male pronucleus", "id": "GO:0044727", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044727", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "5-methylcytosine catabolic process", "id": "GO:0006211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006211", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" }, { "name": "regulation of gene expression", "id": "GO:0010468", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010468", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1393, "end_pos": 1395, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1520, "end_pos": 1522, "annotation": "n_glycosylation_sequon" }, { "start_pos": 234, "end_pos": 236, "annotation": "n_glycosylation_sequon" }, { "start_pos": 351, "end_pos": 353, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Monoubiquitinated at Lys-994 by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(VprBP) or CUL4A-RBX1-DDB1-DCAF1/VPRBP complex; this modification promotes binding to DNA.", "evidence": [ { "database": "UniProtKB", "id": "O43151", "url": "https://www.uniprot.org/uniprot/O43151" }, { "database": "PubMed", "id": "25557551", "url": "https://glygen.org/publication/PubMed/25557551" } ] } ], "interactions": [], "reactions": [ { "id": "52636", "name": "", "equation": "2-oxoglutarate + a 5-methyl-2'-deoxycytidine in DNA + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + CO2 + succinate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4AC33-1", "D3ZQT7-1", "F1LUQ3-1", "Q8NFU7-1", "O43151-1", "Q6N021-1", "Q4JK59-1", "Q3URK3-1", "Q8BG87-1", "M9NEY8-1" ], "evidence": [ { "id": "52636", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/52636" } ] }, { "id": "53828", "name": "", "equation": "2-oxoglutarate + a 5-hydroxymethyl-2'-deoxycytidine in DNA + O2 = a 5-formyl-2'-deoxycytidine in DNA + CO2 + H2O + succinate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4AC33-1", "D3ZQT7-1", "F1LUQ3-1", "Q8NFU7-1", "O43151-1", "Q6N021-1", "Q4JK59-1", "Q3URK3-1", "Q8BG87-1", "M9NEY8-1" ], "evidence": [ { "id": "53828", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53828" } ] }, { "id": "53832", "name": "", "equation": "2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H(+) + succinate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "D4AC33-1", "D3ZQT7-1", "F1LUQ3-1", "Q8NFU7-1", "O43151-1", "Q6N021-1", "Q4JK59-1", "Q3URK3-1", "Q8BG87-1", "M9NEY8-1" ], "evidence": [ { "id": "53832", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53832" } ] }, { "id": "R-HSA-5220952", "name": "TET1,2,3 oxidizes 5-formylcytosine to 5-carboxylcytosine", "equation": "", "summary": "As inferred from mouse, TET1, TET2, and TET3 each oxidize 5-formylcytosine (5-fC) in DNA using molecular oxygen and 2-oxoglutarate to yield 5-carboxylcytosine (5-caC).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-5221062" ], "output_participant_list": [ "R-ALL-5220996" ], "enzyme_list": [ "O43151-1", "Q6N021-1", "Q8NFU7-1" ], "evidence": [ { "id": "R-HSA-5220952", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5220952" } ] }, { "id": "R-HSA-5220990", "name": "TET1,2,3 oxidizes 5-hydroxymethylcytosine to 5-formylcytosine", "equation": "", "summary": "As inferred from mouse, TET1, TET2, and TET3 oxidize 5-hydroxymethylcytosine (5-hmC) in DNA using molecular oxygen and 2-oxoglutarate to yield 5-formylcytosine (5-fC), carbon dioxide, and succinate.", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-5221008" ], "output_participant_list": [], "enzyme_list": [ "O43151-1", "Q6N021-1", "Q8NFU7-1" ], "evidence": [ { "id": "R-HSA-5220990", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5220990" } ] }, { "id": "R-HSA-5221014", "name": "TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine", "equation": "", "summary": "TET1, TET2, and TET3 each oxidize the 5-methyl group of 5-methylcytosine (5-mC) in DNA using molecular oxygen and 2-oxoglutarate as substrates and Fe(II) as a cofactor to yield 5-hydroxymethylcytosine (5-hmC), carbon dioxide, and succinate (Tahiliani et al. 2009, inferred from mouse in Ito et al. 2010). As inferred from mouse, sodium ascorbate (vitamin C) is required for full activity of these enzymes, presumably to maintain the ferrous state of iron (Fe2+) by acting as a reducing agent (Blaschke et al. 2013, Minor et al., 2013). The crystal structure of TET2 indicates that it binds specifically to 5-mC in CG dinucleotides and flips the base out of the helix into proximity of the catalytic Fe(II) where it is oxidized (Hu et al. 2013). TET3 is expressed in murine oocytes and zygotes and is implicated in demethylation of the male pronucleus after fertilization (Iqbal et al. 2011). As inferred from mouse, TET1 and TET2 appear to participate in differentiation of stem cells. TET1,TET2, and TET3 are involved in establishing the increased level of 5-hmC that is characteristic of adult neurons (Guo et al. 2011, inferred from mouse in Hahn et al. 2013). TET2 is expressed in hematopoietic cells where it appears to act as a tumor suppressor (Ko et al. 2010).", "cellular_location": "nucleoplasm", "input_participant_list": [ "R-ALL-212172" ], "output_participant_list": [ "R-ALL-159939", "R-ALL-159942" ], "enzyme_list": [ "O43151-1", "Q6N021-1", "Q8NFU7-1" ], "evidence": [ { "id": "R-HSA-5221014", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-5221014" } ] }, { "id": "R-HSA-9817458", "name": "TET3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine in chromatin containing histone H3.3", "equation": "", "summary": "TET3 supplied by maternal cytoplasm is the major enzyme catalyzing oxidation of 5-methylcytidine to 5-hydroxymethylcytidine in the male pronucleus (inferred from mouse homologs in mouse zygotes). TET3-catalyzed demethylation is part of the second phase of active demethylation in the male pronucleus (inferred from mouse zygotes). The first phase appears to be catalyzed by cytidine deamination followed by base excision repair (inferred from mouse zygotes). Accumulation of 5-hydroxymethylcytidine requires the cytosine methylases DNMT3A and DNMT1 (inferred from mouse homologs in mouse zygotes). TET3 is present in both pronuclei of the zygote, however maternal 5-methylcytidine is protected from oxidation by DPPA3 (PGC7) bound to dimethyllysine-9 of histone H3 in maternal chromatin (inferred from mouse homologs in Nakamura et al. 2007, Nakamura et al. 2012). TET3 interacts with STGP4 (GSE), which interacts with METTL23 to localize TET3 to chromatin in pronuclei (inferred from mouse homologs in Hatanaka et al. 2017). TET1 and TET2 may also play a role in production of hydroxycytidine in the paternal genome (inferred from mouse embryos in Ficz et al. 2011).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [ "R-HSA-212287", "R-HSA-212181" ], "enzyme_list": [ "O43151-1", "Q86XA0-1" ], "evidence": [ { "id": "R-HSA-9817458", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9817458" } ] }, { "id": "R-HSA-9822591", "name": "TET3 binds chromatin with H3K17me2a and 5-mC:METTL23:STGP4", "equation": "", "summary": "STGP4 (GSE) interacts with TET3 and is required for localizing TET3 to the pronuclei of zygotes (inferred from mouse homologs). Within the pronuclei, STGP4 is bound to METTL23, which binds chromatin, possibly via dimethylarginine-17 of histone H3.3 (inferred from mouse homologs).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O43151-1", "Q86XA0-1" ], "evidence": [ { "id": "R-HSA-9822591", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9822591" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-159939", "participant_name": "SUCCA [nucleoplasm]", "crossref": [ { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "30031", "database": "ChEBI", "url": "" }, { "id": "000000895030", "database": "ZINC", "url": "" }, { "id": "C00042", "database": "COMPOUND", "url": "" } ] }, { "participant_id": "R-ALL-159942", "participant_name": "CO2 [nucleoplasm]", "crossref": [ { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" }, { "id": "C00011", "database": "COMPOUND", "url": "" }, { "id": "16526", "database": "ChEBI", "url": "" }, { "id": "HMDB0001967", "database": "HMDB Metabolite", "url": "" }, { "id": "11533283", "database": "PubChem Substance", "url": "" } ] }, { "participant_id": "R-ALL-212172", "participant_name": "DNA containing 5-mC [nucleoplasm]", "crossref": [ { "id": "C02967", "database": "COMPOUND", "url": "" }, { "id": "27551", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" }, { "id": "C02967", "database": "COMPOUND", "url": "" }, { "id": "27551", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5220996", "participant_name": "DNA containing 5-caC [nucleoplasm]", "crossref": [ { "id": "4705", "database": "ChEBI", "url": "" }, { "id": "76793", "database": "ChEBI", "url": "" }, { "id": "76793", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" }, { "id": "76793", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" }, { "id": "76793", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" }, { "id": "76793", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5221008", "participant_name": "DNA containing 5-hmC [nucleoplasm]", "crossref": [ { "id": "76792", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" }, { "id": "76792", "database": "ChEBI", "url": "" }, { "id": "4705", "database": "ChEBI", "url": "" } ] }, { "participant_id": "R-ALL-5221062", "participant_name": "DNA containing 5-fC [nucleoplasm]", "crossref": [ { "id": "76794", "database": "ChEBI", "url": "" }, { 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