{ "uniprot_canonical_ac": "O21048-1", "uniprot_ac": "O21048", "uniprot_id": "NU2M_DICDI", "mass": { "chemical_mass": 54842.0, "monoisotopic_mass": 54842.0 }, "refseq": { "ac": "NP_050070", "name": "NADH dehydrogenase subunit 2", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_050070" }, "gene_names": [ { "name": "nad2", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O21048", "id": "O21048" }, { "name": "DDB_G0294020", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O21048", "id": "O21048" }, { "name": "nad2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_050070", "id": "NP_050070" } ], "protein_names": [ { "name": "NADH-ubiquinone oxidoreductase chain 2", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O21048" }, { "name": "7.1.1.2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O21048" }, { "name": "NADH dehydrogenase subunit 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_050070", "id": "NP_050070" }, { "name": "NADH dehydrogenase subunit 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O21048" } ], "function": [ { "annotation": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "nad2", "url": "https://www.uniprot.org/uniprot/O21048", "locus": {} } ], "crossref": [ { "id": "DDB_G0294020", "url": "http://dictybase.org/gene/DDB_G0294020", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "2193892", "url": "https://www.ncbi.nlm.nih.gov/gene/2193892", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001750", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001750", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DidioMp03", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DidioMp03", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "FYIRVIV", "url": "https://omabrowser.org/oma/group/FYIRVIV/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR22773", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22773", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR22773:SF41", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR22773:SF41", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00361", "url": "http://pfam.xfam.org/family/PF00361", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O21048", "url": "http://purl.obolibrary.org/obo/PR_O21048", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_050070", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_050070", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "29091", "url": "https://www.rhea-db.org/rhea/29091", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O21048-1", "url": "https://www.uniprot.org/uniprot/O21048-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MMFLFENSINMIKYSIYLVPLIIMILLSISIKEDSNRMMLLFKSLKLTIILILVLLTIEEAIYVKLNGHLIKTELITFVEYILLVVSYLIISMFEEGVKEGRKTKITEEALILMYSSLIGMLISMEAHNLITLFLSLEITSICFYILALNKNSRKVSIEGGLKYYIIGGIASTIILLGIVSIYKNTGSLMYTDILVIGMERIGNYQVQMGIALIVLGLIIKLGVAPFHGWLIDTYEGTGMLMTFYLTITQKIVTIIVLINLYKNLITYLNIEVINKGLLVLILVTLIVGTVGSLRQQKVIRFIAYSAIVNSALLILFFVGNNTEELIIYSIYYLINYIIGLAVLINIIIGVVKTKNGGNIEILSELKNIWLNNKVIGISLIIVLIYLAGLPPFTNFISKIILILPLIVEGKIYITMIIFFLTVGIMIYYMNVVKIIIIDKKQEVGVETYKMTKGGSITNIVGGIIWIIISQIYLDEIISIIKIIVAIN", "length": 488, "header": "sp|O21048-1|NU2M_DICDI Isoform 1 of NADH-ubiquinone oxidoreductase chain 2 OS=Dictyostelium discoideum OX=44689 GN=nad2 PE=3 SV=1 CANONICAL=O21048-1" }, "isoforms": [ { "isoform_ac": "O21048-1", "url": "", "sequence": { "sequence": "MMFLFENSINMIKYSIYLVPLIIMILLSISIKEDSNRMMLLFKSLKLTIILILVLLTIEEAIYVKLNGHLIKTELITFVEYILLVVSYLIISMFEEGVKEGRKTKITEEALILMYSSLIGMLISMEAHNLITLFLSLEITSICFYILALNKNSRKVSIEGGLKYYIIGGIASTIILLGIVSIYKNTGSLMYTDILVIGMERIGNYQVQMGIALIVLGLIIKLGVAPFHGWLIDTYEGTGMLMTFYLTITQKIVTIIVLINLYKNLITYLNIEVINKGLLVLILVTLIVGTVGSLRQQKVIRFIAYSAIVNSALLILFFVGNNTEELIIYSIYYLINYIIGLAVLINIIIGVVKTKNGGNIEILSELKNIWLNNKVIGISLIIVLIYLAGLPPFTNFISKIILILPLIVEGKIYITMIIFFLTVGIMIYYMNVVKIIIIDKKQEVGVETYKMTKGGSITNIVGGIIWIIISQIYLDEIISIIKIIVAIN", "length": 488, "header": "sp|O21048-1|NU2M_DICDI Isoform 1 of NADH-ubiquinone oxidoreductase chain 2 OS=Dictyostelium discoideum OX=44689 GN=nad2 PE=3 SV=1 CANONICAL=O21048-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization.", "journal": "Mol. Gen. Genet.", "date": "2000", "authors": "Ogawa S, Yoshino R, Angata K, Iwamoto M, Pi M, Kuroe K, Matsuo K, Morio T, Urushihara H, Yanagisawa K, Tanaka Y", "evidence": [ { "database": "UniProtKB", "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048" } ], "reference": [ { "type": "PubMed", "id": "10821186", "url": "https://glygen.org/publication/PubMed/10821186" } ] }, { "title": "Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene.", "journal": "Curr. Genet.", "date": "1997", "authors": "Ogawa S, Matsuo K, Angata K, Yanagisawa K, Tanaka Y", "evidence": [ { "database": "UniProtKB", "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048" } ], "reference": [ { "type": "PubMed", "id": "9000384", "url": "https://glygen.org/publication/PubMed/9000384" } ] } ], "pathway": [ { "id": "ddi:DidioMp03", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DidioMp03", "resource": "KEGG Pathway" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "mitochondrial inner membrane", "id": "GO:0005743", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "evidence": [ { "database": "UniProtKB", "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048" } ], "pmid": "" }, { "name": "respirasome", "id": "GO:0070469", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070469", "evidence": [ { "database": "UniProtKB", "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "NADH dehydrogenase (ubiquinone) activity", "id": "GO:0008137", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008137", "evidence": [ { "database": "UniProtKB", "id": "O21048", "url": "https://www.uniprot.org/uniprot/O21048" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 321, "end_pos": 323, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "29091", "name": "", "equation": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P03889-1", "P11662-1", "P19234-1", "P05507-1", "Q66HF1-1", "P05506-1", "P05508-1", "P11661-1", "Q641Y2-1", "P03926-1", "Q5XIH3-1", "P03897-1", "P03915-1", "P03923-1", "P03891-1", "P03905-1", "P03886-1", "P28331-1", "O00217-1", "O75306-1", "O75489-1", "O75251-1", "P49821-1", "P19404-1", "P03901-1", "P03888-1", "Q91VD9-1", "Q91WD5-1", "Q8K3J1-1", "P03899-1", "P03921-1", "P03893-1", "P03911-1", "P03925-1", "Q9DCT2-1", "Q9DC70-1", "P03903-1", "Q91YT0-1", "Q9D6J6-1", "Q55CD9-1", "O21047-1", "O21048-1", "P22237-1", "Q34313-1", "Q37312-1", "Q37313-1", "Q37314-1", "Q54F10-1", "Q9XK79-1", "Q23883-1", "Q34312-1", "Q54I90-1", "P18930-1", "P18931-1", "P18932-1", "P18934-1", "Q94511-1", "Q9VF27-1", "Q9VZU4-1", "P03896-1", "P18929-1", "P18933-1", "Q9VMI3-1" ], "evidence": [ { "id": "29091", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/29091" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "O00217", "gene_name": "NDUFS8", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O00217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00217" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O00217", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00217" } ] } ] }, { "uniprot_ac": "O21047", "gene_name": "nad4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O21047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21047" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O21047", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21047" } ] } ] }, { "uniprot_ac": "O21048", "gene_name": "nad2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O21048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21048" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O21048", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O21048" } ] } ] }, { "uniprot_ac": "O75251", "gene_name": "NDUFS7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O75251", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75251" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O75251", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75251" } ] } ] }, { "uniprot_ac": "O75306", "gene_name": "NDUFS2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O75306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75306" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O75306", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75306" } ] } ] }, { "uniprot_ac": "O75489", "gene_name": "NDUFS3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "O75489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75489" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "O75489", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75489" } ] } ] }, { "uniprot_ac": "P03886", "gene_name": "MT-ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03886", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03886" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03886", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03886" } ] } ] }, { "uniprot_ac": "P03888", "gene_name": "Mtnd1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03888" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03888" } ] } ] }, { "uniprot_ac": "P03889", "gene_name": "Mtnd1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03889" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03889", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03889" } ] } ] }, { "uniprot_ac": "P03891", "gene_name": "MT-ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03891" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03891", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03891" } ] } ] }, { "uniprot_ac": "P03893", "gene_name": "mt-Nd2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03893" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03893", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03893" } ] } ] }, { "uniprot_ac": "P03896", "gene_name": "mt:ND2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03896" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03896", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03896" } ] } ] }, { "uniprot_ac": "P03897", "gene_name": "MT-ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03897" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03897", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03897" } ] } ] }, { "uniprot_ac": "P03899", "gene_name": "mt-Nd3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03899" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03899", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03899" } ] } ] }, { "uniprot_ac": "P03901", "gene_name": "MT-ND4L", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03901" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03901", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03901" } ] } ] }, { "uniprot_ac": "P03903", "gene_name": "Mtnd4l", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03903" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03903", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03903" } ] } ] }, { "uniprot_ac": "P03905", "gene_name": "MT-ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03905" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03905", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03905" } ] } ] }, { "uniprot_ac": "P03911", "gene_name": "Mtnd4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03911" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03911" } ] } ] }, { "uniprot_ac": "P03915", "gene_name": "MT-ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03915" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03915", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03915" } ] } ] }, { "uniprot_ac": "P03921", "gene_name": "Mtnd5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03921" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03921", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03921" } ] } ] }, { "uniprot_ac": "P03923", "gene_name": "MT-ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03923" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03923" } ] } ] }, { "uniprot_ac": "P03925", "gene_name": "Mtnd6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03925" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03925" } ] } ] }, { "uniprot_ac": "P03926", "gene_name": "Mtnd6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P03926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03926" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P03926", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P03926" } ] } ] }, { "uniprot_ac": "P05506", "gene_name": "mt-Nd3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P05506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05506" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P05506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05506" } ] } ] }, { "uniprot_ac": "P05507", "gene_name": "Mtnd4l", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P05507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05507" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P05507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05507" } ] } ] }, { "uniprot_ac": "P05508", "gene_name": "Mtnd4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P05508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05508" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P05508", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05508" } ] } ] }, { "uniprot_ac": "P11661", "gene_name": "Mtnd5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P11661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11661" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P11661", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11661" } ] } ] }, { "uniprot_ac": "P11662", "gene_name": "mt-Nd2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P11662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11662" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P11662", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11662" } ] } ] }, { "uniprot_ac": "P18929", "gene_name": "mt:ND1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18929" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18929", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18929" } ] } ] }, { "uniprot_ac": "P18930", "gene_name": "mt:ND3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18930" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18930", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18930" } ] } ] }, { "uniprot_ac": "P18931", "gene_name": "mt:ND4", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18931" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18931" } ] } ] }, { "uniprot_ac": "P18932", "gene_name": "mt:ND5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18932" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18932" } ] } ] }, { "uniprot_ac": "P18933", "gene_name": "mt:ND6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18933" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18933", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18933" } ] } ] }, { "uniprot_ac": "P18934", "gene_name": "mt:ND4L", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P18934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18934" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P18934", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18934" } ] } ] }, { "uniprot_ac": "P19234", "gene_name": "Ndufv2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P19234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19234" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P19234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19234" } ] } ] }, { "uniprot_ac": "P19404", "gene_name": "NDUFV2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P19404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19404" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P19404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19404" } ] } ] }, { "uniprot_ac": "P22237", "gene_name": "nad9", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P22237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22237" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P22237", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22237" } ] } ] }, { "uniprot_ac": "P28331", "gene_name": "NDUFS1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P28331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28331" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P28331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28331" } ] } ] }, { "uniprot_ac": "P49821", "gene_name": "NDUFV1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "P49821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49821" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "P49821", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49821" } ] } ] }, { "uniprot_ac": "Q23883", "gene_name": "nad7", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q23883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23883" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q23883", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23883" } ] } ] }, { "uniprot_ac": "Q34312", "gene_name": "nad11", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q34312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34312" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q34312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34312" } ] } ] }, { "uniprot_ac": "Q34313", "gene_name": "nad5", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q34313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34313" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q34313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q34313" } ] } ] }, { "uniprot_ac": "Q37312", "gene_name": "nad3", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q37312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37312" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q37312", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37312" } ] } ] }, { "uniprot_ac": "Q37313", "gene_name": "nad1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q37313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37313" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q37313", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37313" } ] } ] }, { "uniprot_ac": "Q37314", "gene_name": "nad6", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q37314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37314" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q37314", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q37314" } ] } ] }, { "uniprot_ac": "Q54F10", "gene_name": "ndufv2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q54F10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54F10" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q54F10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54F10" } ] } ] }, { "uniprot_ac": "Q54I90", "gene_name": "ndufv1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q54I90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I90" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q54I90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I90" } ] } ] }, { "uniprot_ac": "Q55CD9", "gene_name": "", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q55CD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CD9" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q55CD9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CD9" } ] } ] }, { "uniprot_ac": "Q5XIH3", "gene_name": "Ndufv1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q5XIH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIH3" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q5XIH3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5XIH3" } ] } ] }, { "uniprot_ac": "Q641Y2", "gene_name": "Ndufs2", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q641Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641Y2" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q641Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q641Y2" } ] } ] }, { "uniprot_ac": "Q66HF1", "gene_name": "Ndufs1", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q66HF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q66HF1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66HF1" } ] } ] }, { "uniprot_ac": "Q8K3J1", "gene_name": "Ndufs8", "activity": [ { "ec_number": "7.1.1.2", "activity": "a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+).", "evidence": [ { "id": "Q8K3J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3J1" } ] }, { "ec_number": "7.1.1.2", "activity": "", "evidence": [ { "id": "Q8K3J1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K3J1" } ] } 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