{ "uniprot_canonical_ac": "O15736-1", "uniprot_ac": "O15736", "uniprot_id": "TIPD_DICDI", "mass": { "chemical_mass": 68747.0, "monoisotopic_mass": 68747.0 }, "refseq": { "ac": "XP_643673", "name": "autophagy protein 16", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643673" }, "gene_names": [ { "name": "tipD", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15736", "id": "O15736" }, { "name": "DDB_G0275323", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15736", "id": "O15736" }, { "name": "tipD", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643673", "id": "XP_643673" } ], "protein_names": [ { "name": "Protein tipD", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15736" }, { "name": "autophagy protein 16", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643673", "id": "XP_643673" } ], "function": [ { "annotation": "Not known; disruption of the gene for tipD results in morphological defects.", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736#function" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [], "expression_disease": [], "species": [ { "name": "Dictyostelium discoideum", "taxid": 44689, "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "common_name": "Cellular slime molds" } ], "gene": [ { "name": "tipD", "url": "https://www.uniprot.org/uniprot/O15736", "locus": {} } ], "crossref": [ { "id": "cd00200", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00200", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd22887", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd22887", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "DDB_G0275323", "url": "http://dictybase.org/gene/DDB_G0275323", "database": "dictyBase", "categories": [ "Organism-specific" ] }, { "id": "8619939", "url": "https://www.ncbi.nlm.nih.gov/gene/8619939", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "IPR001680", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001680", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013923", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013923", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR015943", "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019775", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019775", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020472", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020472", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036322", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR045160", "url": "https://www.ebi.ac.uk/interpro/entry/IPR045160", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "ddi:DDB_G0275323", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0275323", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "GRPCISP", "url": "https://omabrowser.org/oma/group/GRPCISP/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "PTHR19878", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19878", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR19878:SF8", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR19878:SF8", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00400", "url": "http://pfam.xfam.org/family/PF00400", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF08614", "url": "http://pfam.xfam.org/family/PF08614", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PR_O15736", "url": "http://purl.obolibrary.org/obo/PR_O15736", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-DDI-1632852", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1632852", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "XP_643673", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_643673", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15736-1", "url": "https://www.uniprot.org/uniprot/O15736-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MFSSQNNSYMMMMGGGGIGNINNNQFYSPIISTSAQSFNSIVEWKRDIIRQLNDRNQNQTNNYSEFMRIYTDLLKRERTLNDRTLLYEKEIVSLRNEKKTQQQPPSGSSKMDSSSSSSSSNRVSGMGSTIEEMEQKLFKLQEDLTNSYKRNADNASSILLLNDKNKDLQNELMSKEIEIERIRSTIQQDLDSIKRLEMVVIEKENVSQIIRDELSSLQTEFLHNESKVVKLEQENSSLVERWLRKKNEEASKMNEANDFYQKMVEQRDSTPAKAAVQLSESISNLVVKLPDANDVPIPIVLERGVFSSEAMLPSKAKKRWTGHNSEIYCMAFNSIGNLLATGGGDKCVKVWDVISGQQKSTLLGASQSIVSVSFSPNDESILGTSNDNSARLWNTELGRSRHTLTGHIGKVYTGKFINSNRVVTGSHDRTIKLWDLQKGYCTRTIFCFSSCNDLVILGGSGTHLASGHVDHSVRFWDSNAGEPTQVLSSIHEGQITSITNSPTNTNQILTNSRDHTLKIIDIRTFDTIRTFKDPEYRNGLNWTKASWSPDGRYIASGSIDGSICIWDATNGKTVKVLTKVHNNGSSVCCCSWSPLANIFISADKDKNIIQWE", "length": 612, "header": "sp|O15736-1|TIPD_DICDI Isoform 1 of Protein tipD OS=Dictyostelium discoideum OX=44689 GN=tipD PE=3 SV=1 CANONICAL=O15736-1" }, "isoforms": [ { "isoform_ac": "O15736-1", "url": "", "sequence": { "sequence": "MFSSQNNSYMMMMGGGGIGNINNNQFYSPIISTSAQSFNSIVEWKRDIIRQLNDRNQNQTNNYSEFMRIYTDLLKRERTLNDRTLLYEKEIVSLRNEKKTQQQPPSGSSKMDSSSSSSSSNRVSGMGSTIEEMEQKLFKLQEDLTNSYKRNADNASSILLLNDKNKDLQNELMSKEIEIERIRSTIQQDLDSIKRLEMVVIEKENVSQIIRDELSSLQTEFLHNESKVVKLEQENSSLVERWLRKKNEEASKMNEANDFYQKMVEQRDSTPAKAAVQLSESISNLVVKLPDANDVPIPIVLERGVFSSEAMLPSKAKKRWTGHNSEIYCMAFNSIGNLLATGGGDKCVKVWDVISGQQKSTLLGASQSIVSVSFSPNDESILGTSNDNSARLWNTELGRSRHTLTGHIGKVYTGKFINSNRVVTGSHDRTIKLWDLQKGYCTRTIFCFSSCNDLVILGGSGTHLASGHVDHSVRFWDSNAGEPTQVLSSIHEGQITSITNSPTNTNQILTNSRDHTLKIIDIRTFDTIRTFKDPEYRNGLNWTKASWSPDGRYIASGSIDGSICIWDATNGKTVKVLTKVHNNGSSVCCCSWSPLANIFISADKDKNIIQWE", "length": 612, "header": "sp|O15736-1|TIPD_DICDI Isoform 1 of Protein tipD OS=Dictyostelium discoideum OX=44689 GN=tipD PE=3 SV=1 CANONICAL=O15736-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.", "journal": "Nature", "date": "2002", "authors": "Gl\u00f6ckner Gernot, Eichinger Ludwig, Szafranski Karol, Pachebat Justin A, Bankier Alan T, Dear Paul H, Lehmann R\u00fcdiger, Baumgart Cornelia, Parra Gen\u00eds, Abril Josep F, Guig\u00f3 Roderic, Kumpf Kai, Tunggal Budi, Cox Edward, Quail Michael A, Platzer Matthias, Rosenthal Andr\u00e9, Noegel Angelika A,", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "reference": [ { "type": "PubMed", "id": "12097910", "url": "https://glygen.org/publication/PubMed/12097910" } ] }, { "title": "The genome of the social amoeba Dictyostelium discoideum.", "journal": "Nature", "date": "2005", "authors": "Eichinger L, Pachebat J A, Gl\u00f6ckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov B A, Rivero F, Bankier A T, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail M A, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox E C, Chisholm R L, Gibbs R, Loomis W F, Platzer M, Kay R R, Williams J, Dear P H, Noegel A A, Barrell B, Kuspa A", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "reference": [ { "type": "PubMed", "id": "15875012", "url": "https://glygen.org/publication/PubMed/15875012" } ] } ], "pathway": [ { "id": "ddi:DDB_G0275323", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+ddi:DDB_G0275323", "resource": "KEGG Pathway" }, { "id": "R-DDI-1632852", "name": "Macroautophagy", "url": "https://www.reactome.org/PathwayBrowser/#R-DDI-1632852", "resource": "Reactome", "description": "Macroautophagy" } ], "orthologs": [], "go_annotation": { "categories": [ { "name": "Biological Process", "total": 8, "go_terms": [ { "name": "autophagosome maturation", "id": "GO:0097352", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097352", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "autophagosome assembly", "id": "GO:0000045", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "phagocytosis", "id": "GO:0006909", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006909", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "macroautophagy", "id": "GO:0016236", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016236", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "proteasome-mediated ubiquitin-dependent protein catabolic process", "id": "GO:0043161", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043161", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "pinocytosis", "id": "GO:0006907", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006907", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "sorocarp development", "id": "GO:0030587", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030587", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "culmination involved in sorocarp development", "id": "GO:0031154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031154", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 3, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "extracellular matrix", "id": "GO:0031012", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" }, { "name": "Atg12-Atg5-Atg16 complex", "id": "GO:0034274", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034274", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 1, "go_terms": [ { "name": "Atg8-family ligase activity", "id": "GO:0019776", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019776", "evidence": [ { "database": "UniProtKB", "id": "O15736", "url": "https://www.uniprot.org/uniprot/O15736" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 154, "end_pos": 156, "annotation": "n_glycosylation_sequon" }, { "start_pos": 205, "end_pos": 207, "annotation": "n_glycosylation_sequon" }, { "start_pos": 224, "end_pos": 226, "annotation": "n_glycosylation_sequon" }, { "start_pos": 235, "end_pos": 237, "annotation": "n_glycosylation_sequon" }, { "start_pos": 541, "end_pos": 543, "annotation": "n_glycosylation_sequon" }, { "start_pos": 583, "end_pos": 585, "annotation": 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