{
"uniprot_canonical_ac": "O15357-1",
"uniprot_ac": "O15357",
"uniprot_id": "SHIP2_HUMAN",
"mass": {
"chemical_mass": 138599.0,
"monoisotopic_mass": 138599.0
},
"refseq": {
"ac": "NP_001558",
"name": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2",
"summary": "The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009].",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
},
"gene_names": [
{
"name": "INPPL1",
"resource": "UniProtKB",
"type": "recommended",
"url": "https://www.uniprot.org/uniprot/O15357",
"id": "O15357"
},
{
"name": "INPPL1",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558",
"id": "NP_001558"
},
{
"name": "OPSMD; SHIP2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558",
"id": "NP_001558"
},
{
"name": "SHIP2",
"resource": "UniProtKB",
"type": "synonym",
"url": "https://www.uniprot.org/uniprot/O15357",
"id": "O15357"
}
],
"protein_names": [
{
"name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2",
"resource": "UniProtKB",
"type": "recommended",
"url": "",
"id": "O15357"
},
{
"name": "3.1.3.86",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O15357"
},
{
"name": "INPPL-1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O15357"
},
{
"name": "Inositol polyphosphate phosphatase-like protein 1",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O15357"
},
{
"name": "Protein 51C",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O15357"
},
{
"name": "SH2 domain-containing inositol 5'-phosphatase 2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O15357"
},
{
"name": "SH2 domain-containing inositol phosphatase 2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O15357"
},
{
"name": "SH2 domain-containing inositol-5'-phosphatase 2; 51C protein; SHIP-2; INPPL-1; protein 51C",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558",
"id": "NP_001558"
},
{
"name": "SHIP-2",
"resource": "UniProtKB",
"type": "synonym",
"url": "",
"id": "O15357"
},
{
"name": "phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2",
"resource": "RefSeq",
"type": "synonym",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558",
"id": "NP_001558"
}
],
"function": [
{
"annotation": "A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
},
{
"database": "PubMed",
"id": "34314064",
"url": "https://glygen.org/publication/PubMed/34314064"
}
]
},
{
"annotation": "OxLDL-stimulated macrophage exosomes promote proatherogenic vascular smooth muscle cell viability and invasion via delivering miR-186-5p then inactivating SHIP2 mediated PI3K/AKT/mTOR pathway.",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
},
{
"database": "PubMed",
"id": "35421738",
"url": "https://glygen.org/publication/PubMed/35421738"
}
]
},
{
"annotation": "PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer. Publication Status: Online-Only",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
},
{
"database": "PubMed",
"id": "38200519",
"url": "https://glygen.org/publication/PubMed/38200519"
}
]
},
{
"annotation": "Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:16824732). Required for correct mitotic spindle orientation and therefore progression of mitosis (By similarity). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear (PubMed:9660833). While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking (By similarity). Confers resistance to dietary obesity (By similarity). May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane (By similarity). Part of a signaling pathway that regulates actin cytoskeleton remodeling (PubMed:11739414, PubMed:12676785). Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation (PubMed:15668240). Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (PubMed:21624956). Regulates cell adhesion and cell spreading (PubMed:12235291). Required for HGF-mediated lamellipodium formation, cell scattering and spreading (PubMed:15735664). Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation (PubMed:17135240). Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth (By similarity). Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A) (PubMed:12690104). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems (PubMed:11016922). Involved in EGF signaling pathway (PubMed:11349134). Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3 (PubMed:11349134). Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity (PubMed:11349134). Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1 (By similarity). In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling (By similarity). Plays a role in the localization of AURKA and NEDD9/HEF1 to the basolateral membrane at interphase in polarized cysts, thereby mediates cell cycle homeostasis, cell polarization and cilia assembly (By similarity). Additionally promotion of cilia growth is also facilitated by hydrolysis of (PtdIns(3,4,5)P3) to PtdIns(3,4)P2 (By similarity). Promotes formation of apical membrane-initiation sites during the initial stages of lumen formation via Rho family-induced actin filament organization and CTNNB1 localization to cell-cell contacts (By similarity). May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (PubMed:23273569).",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357#function"
},
{
"database": "UniProtKB",
"id": "Q6P549",
"url": "https://www.uniprot.org/uniprot/Q6P549#function"
},
{
"database": "PubMed",
"id": "9660833",
"url": "https://glygen.org/publication/PubMed/9660833"
},
{
"database": "PubMed",
"id": "16824732",
"url": "https://glygen.org/publication/PubMed/16824732"
},
{
"database": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
},
{
"database": "PubMed",
"id": "23273569",
"url": "https://glygen.org/publication/PubMed/23273569"
},
{
"database": "PubMed",
"id": "15735664",
"url": "https://glygen.org/publication/PubMed/15735664"
},
{
"database": "PubMed",
"id": "21624956",
"url": "https://glygen.org/publication/PubMed/21624956"
},
{
"database": "PubMed",
"id": "12676785",
"url": "https://glygen.org/publication/PubMed/12676785"
},
{
"database": "PubMed",
"id": "11739414",
"url": "https://glygen.org/publication/PubMed/11739414"
},
{
"database": "PubMed",
"id": "12690104",
"url": "https://glygen.org/publication/PubMed/12690104"
},
{
"database": "PubMed",
"id": "11349134",
"url": "https://glygen.org/publication/PubMed/11349134"
},
{
"database": "UniProtKB",
"id": "F1PNY0",
"url": "https://www.uniprot.org/uniprot/F1PNY0#function"
},
{
"database": "PubMed",
"id": "11016922",
"url": "https://glygen.org/publication/PubMed/11016922"
},
{
"database": "PubMed",
"id": "17135240",
"url": "https://glygen.org/publication/PubMed/17135240"
},
{
"database": "UniProtKB",
"id": "Q9WVR3",
"url": "https://www.uniprot.org/uniprot/Q9WVR3#function"
},
{
"database": "PubMed",
"id": "15668240",
"url": "https://glygen.org/publication/PubMed/15668240"
}
]
},
{
"annotation": "The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009].",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
}
]
}
],
"disease": [
{
"disease_id": "MONDO:0009785",
"recommended_name": {
"id": "MONDO:0009785",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009785",
"name": "opsismodysplasia",
"description": "Opsismodysplasia is a skeletal dysplasia characterized by congenital dwarfism and facial dysmorphism."
},
"synonyms": [
{
"id": "MONDO:0009785",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009785",
"name": "opsismodysplasia",
"description": ""
},
{
"id": "MONDO:0009785",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009785",
"name": "OPSISMODYSPLASIA",
"description": ""
},
{
"id": "MONDO:0009785",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0009785",
"name": "OPSMD",
"description": ""
},
{
"id": "MIM:258480",
"resource": "MIM",
"url": "https://www.omim.org/entry/258480",
"name": "Opsismodysplasia",
"description": "Opsismodysplasia"
}
],
"evidence": [
{
"id": "258480",
"database": "MIM",
"url": "https://www.omim.org/entry/258480"
}
]
}
],
"snv": [
{
"evidence": [
{
"id": "rs1213970792",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1213970792"
},
{
"id": "rs1213970792",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1213970792#frequency_tab"
},
{
"id": "rs1213970792",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1213970792"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 149,
"end_pos": 149,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SIS->NIS).",
"chr_id": "11",
"chr_pos": "72228775",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S149",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs61736300",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs61736300"
},
{
"id": "rs61736300",
"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs61736300"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 267,
"end_pos": 267,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KLS->NLS).",
"chr_id": "11",
"chr_pos": "72229710",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K267",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1415696831",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1415696831"
},
{
"id": "rs1415696831",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1415696831"
},
{
"id": "rs1415696831",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs1415696831#frequency_tab"
}
],
"glycoeffect": [
"o-glyco-site-loss"
],
"start_pos": 276,
"end_pos": 276,
"sequence_org": "S",
"sequence_mut": "*",
"comment": "Somatic mutation passed 1 out of 1 filters: o-glyco-site-loss (S->*).",
"chr_id": "11",
"chr_pos": "72229736",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "S276",
"keywords": [
"ebi",
"somatic"
]
},
{
"evidence": [
{
"id": "rs201624140",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201624140"
},
{
"id": "rs201624140",
"database": "1000Genomes",
"url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs201624140"
},
{
"id": "rs201624140",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs201624140"
},
{
"id": "rs201624140",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs201624140"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 290,
"end_pos": 290,
"sequence_org": "S",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (SST->NST).",
"chr_id": "11",
"chr_pos": "72229949",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "0.0002",
"site_lbl": "S290",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "O15357",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15357"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 686,
"end_pos": 686,
"subjects_tested": "470",
"subjects_positive": "1",
"frequency": "0.2",
"sequence_org": "P",
"sequence_mut": "S",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NVP->NVS).",
"chr_id": "11",
"chr_pos": "72233456",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "P686",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "rs1395218564",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1395218564"
},
{
"id": "rs1395218564",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1395218564"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 717,
"end_pos": 717,
"sequence_org": "D",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DHS->NHS).",
"chr_id": "11",
"chr_pos": "72233681",
"ref_nt": "A",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "D717",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs745723030",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745723030"
},
{
"id": "rs745723030",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs745723030"
},
{
"id": "rs745723030",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs745723030"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 741,
"end_pos": 741,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KTS->NTS).",
"chr_id": "11",
"chr_pos": "72234291",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K741",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1327148210",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1327148210"
},
{
"id": "rs1327148210",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1327148210"
}
],
"glycoeffect": [
"n-glyco-sequon-gain",
"o-glyco-site-loss"
],
"start_pos": 778,
"end_pos": 778,
"sequence_org": "K",
"sequence_mut": "N",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KKS->NKS).",
"chr_id": "11",
"chr_pos": "72234534",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "K778",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs1444112654",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1444112654"
},
{
"id": "rs1444112654",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs1444112654"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 785,
"end_pos": 785,
"sequence_org": "A",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NDA->NDS).",
"chr_id": "11",
"chr_pos": "72234553",
"ref_nt": "T",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "A785",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs780938497",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780938497"
},
{
"id": "rs780938497",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780938497"
},
{
"id": "rs780938497",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs780938497#frequency_tab"
},
{
"id": "rs780938497",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs780938497"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 792,
"end_pos": 792,
"sequence_org": "N",
"sequence_mut": "S",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIN->NIS).",
"chr_id": "11",
"chr_pos": "72234575",
"ref_nt": "G",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N792",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "rs780938497",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780938497"
},
{
"id": "rs780938497",
"database": "ExAC",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs780938497"
},
{
"id": "rs780938497",
"database": "TOPMed",
"url": "https://www.ncbi.nlm.nih.gov/snp/rs780938497#frequency_tab"
},
{
"id": "rs780938497",
"database": "gnomAD",
"url": "http://gnomad.broadinstitute.org/awesome?query=rs780938497"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 792,
"end_pos": 792,
"sequence_org": "N",
"sequence_mut": "T",
"comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NIN->NIT).",
"chr_id": "11",
"chr_pos": "72234575",
"ref_nt": "C",
"alt_nt": "null",
"minor_allelic_frequency": "",
"site_lbl": "N792",
"keywords": [
"ebi",
"germline"
]
},
{
"evidence": [
{
"id": "O15357",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15357"
}
],
"glycoeffect": [],
"start_pos": 938,
"end_pos": 938,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "P",
"sequence_mut": "L",
"comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).",
"chr_id": "11",
"chr_pos": "72235920",
"ref_nt": "C",
"alt_nt": "T",
"minor_allelic_frequency": "",
"site_lbl": "P938",
"disease": [
{
"disease_id": "DOID:4159",
"recommended_name": {
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "skin cancer",
"description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells."
},
"synonyms": [
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "CA - skin cancer",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "malignant neoplasm of skin",
"description": ""
},
{
"id": "DOID:4159",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:4159",
"name": "melanoma and Non-melanoma skin cancer",
"description": ""
}
]
},
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
},
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease"
]
},
{
"evidence": [
{
"id": "O15357",
"database": "BioMuta",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15357"
},
{
"id": "rs892095304",
"database": "dbSNP",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs892095304"
},
{
"id": "rs892095304",
"database": "ENSEMBL",
"url": "https://www.ensembl.org/id/rs892095304"
},
{
"id": "rs892095304",
"database": "NCI-TCGA",
"url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs892095304"
}
],
"glycoeffect": [
"n-glyco-sequon-gain"
],
"start_pos": 984,
"end_pos": 984,
"subjects_tested": "0",
"subjects_positive": "0",
"frequency": "0.0",
"sequence_org": "P",
"sequence_mut": "T",
"comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NNP->NNT).",
"chr_id": "11",
"chr_pos": "72237194",
"ref_nt": "C",
"alt_nt": "A",
"minor_allelic_frequency": "",
"site_lbl": "P984",
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
],
"keywords": [
"biomuta",
"somatic",
"cancer",
"disease",
"ebi",
"germline"
]
}
],
"mutagenesis": [
{
"start_pos": 140,
"end_pos": 141,
"sequence_org": "PL",
"sequence_mut": "AA",
"comment": "Abolishes interaction with SH3YL1.",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "21624956",
"url": "https://glygen.org/publication/PubMed/21624956"
}
]
},
{
"start_pos": 47,
"end_pos": 47,
"sequence_org": "R",
"sequence_mut": "G",
"comment": "Abolishes interaction with p130Cas/BCAR1 and its ability to induce increased adhesion. Abolishes phosphorylation upon FCGR2A clustering.",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "11158326",
"url": "https://glygen.org/publication/PubMed/11158326"
},
{
"database": "PubMed",
"id": "12690104",
"url": "https://glygen.org/publication/PubMed/12690104"
}
]
},
{
"start_pos": 607,
"end_pos": 607,
"sequence_org": "D",
"sequence_mut": "A",
"comment": "Abolishes enzyme activity but not phosphorylation upon FCGR2A clustering.",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "12690104",
"url": "https://glygen.org/publication/PubMed/12690104"
}
]
},
{
"start_pos": 958,
"end_pos": 958,
"sequence_org": "T",
"sequence_mut": "A",
"comment": "Reduces PDGF-stimulated tyrosine phosphorylation and association with SHC1.",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "17219406",
"url": "https://glygen.org/publication/PubMed/17219406"
}
]
},
{
"start_pos": 986,
"end_pos": 987,
"sequence_org": "YY",
"sequence_mut": "FF",
"comment": "Inducer a strong reduction of phosphorylation upon re-plating on collagen I.",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
}
]
}
],
"expression_tissue": [
{
"tissue": {
"name": "Adult mammalian kidney",
"namespace": "UBERON",
"id": "0000082",
"url": "http://purl.obolibrary.org/obo/UBERON_0000082"
},
"score": "85.83",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Oral cavity",
"namespace": "UBERON",
"id": "0000167",
"url": "http://purl.obolibrary.org/obo/UBERON_0000167"
},
"score": "67.84",
"present": "LOW",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Stomach",
"namespace": "UBERON",
"id": "0000945",
"url": "http://purl.obolibrary.org/obo/UBERON_0000945"
},
"score": "91.15",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Uterus",
"namespace": "UBERON",
"id": "0000995",
"url": "http://purl.obolibrary.org/obo/UBERON_0000995"
},
"score": "83.76",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Esophagus",
"namespace": "UBERON",
"id": "0001043",
"url": "http://purl.obolibrary.org/obo/UBERON_0001043"
},
"score": "97.32",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Rectum",
"namespace": "UBERON",
"id": "0001052",
"url": "http://purl.obolibrary.org/obo/UBERON_0001052"
},
"score": "96.37",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Colon",
"namespace": "UBERON",
"id": "0001155",
"url": "http://purl.obolibrary.org/obo/UBERON_0001155"
},
"score": "84.39",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Urinary bladder",
"namespace": "UBERON",
"id": "0001255",
"url": "http://purl.obolibrary.org/obo/UBERON_0001255"
},
"score": "87.08",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Thyroid gland",
"namespace": "UBERON",
"id": "0002046",
"url": "http://purl.obolibrary.org/obo/UBERON_0002046"
},
"score": "95.57",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Lung",
"namespace": "UBERON",
"id": "0002048",
"url": "http://purl.obolibrary.org/obo/UBERON_0002048"
},
"score": "83.65",
"present": "MEDIUM",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Liver",
"namespace": "UBERON",
"id": "0002107",
"url": "http://purl.obolibrary.org/obo/UBERON_0002107"
},
"score": "87.31",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Prostate gland",
"namespace": "UBERON",
"id": "0002367",
"url": "http://purl.obolibrary.org/obo/UBERON_0002367"
},
"score": "98.36",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
},
{
"tissue": {
"name": "Thoracic mammary gland",
"namespace": "UBERON",
"id": "0005200",
"url": "http://purl.obolibrary.org/obo/UBERON_0005200"
},
"score": "95.96",
"present": "HIGH",
"evidence": [
{
"database": "Bgee",
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458"
}
]
}
],
"expression_disease": [
{
"significant": "Yes",
"trend": "up",
"name": "Prostate cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10283",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:10283",
"recommended_name": {
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer",
"description": "A male reproductive organ cancer that is located_in the prostate."
},
"synonyms": [
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "NGP - new growth of prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "malignant tumor of the prostate",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostate neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic cancer",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "prostatic neoplasm",
"description": ""
},
{
"id": "DOID:10283",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10283",
"name": "tumor of the prostate",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "prostate cancer, hereditary, type 9",
"description": ""
},
{
"id": "MONDO:0012597",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012597",
"name": "HPC9",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene."
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "EHBP1 familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "familial prostate cancer caused by mutation in EHBP1",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "prostate cancer, hereditary, type 12",
"description": ""
},
{
"id": "MONDO:0012741",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012741",
"name": "HPC12",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "prostate cancer, hereditary, type 5",
"description": ""
},
{
"id": "MONDO:0012244",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012244",
"name": "HPC5",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, hereditary, type 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "prostate cancer, susceptibility to, 3",
"description": ""
},
{
"id": "MONDO:0012093",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012093",
"name": "HPC3",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, type 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, susceptibility to, 4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "HPC4",
"description": ""
},
{
"id": "MONDO:0012094",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012094",
"name": "prostate cancer, hereditary, on chromosome 7",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene."
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "MSMB familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "familial prostate cancer caused by mutation in MSMB",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "prostate cancer, hereditary, type 13",
"description": ""
},
{
"id": "MONDO:0012758",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012758",
"name": "HPC13",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, hereditary, type 8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "HPC8",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "predisposing for prostate cancer",
"description": ""
},
{
"id": "MONDO:0011270",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011270",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, hereditary, type 6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "HPC6",
"description": ""
},
{
"id": "MONDO:0012300",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012300",
"name": "prostate cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "HPC10",
"description": ""
},
{
"id": "MONDO:0012620",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012620",
"name": "prostate cancer, hereditary, 10",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate carcinoma",
"description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma."
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate cancer",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "hereditary prostate carcinoma",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, somatic",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, familial",
"description": ""
},
{
"id": "MONDO:0023122",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0023122",
"name": "prostate cancer, hereditary",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "HPC7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer, hereditary, 7",
"description": ""
},
{
"id": "MONDO:0012470",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012470",
"name": "prostate cancer aggressiveness",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene."
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "RNASEL familial prostate cancer",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "familial prostate cancer caused by mutation in RNASEL",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "prostate cancer, hereditary, type 1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "HPC1",
"description": ""
},
{
"id": "MONDO:0011098",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0011098",
"name": "Prca1",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "HPC11",
"description": ""
},
{
"id": "MONDO:0012768",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012768",
"name": "prostate cancer, hereditary, 11",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "HPC14",
"description": ""
},
{
"id": "MONDO:0012769",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012769",
"name": "prostate cancer, hereditary, 14",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "HPC15",
"description": ""
},
{
"id": "MONDO:0012770",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012770",
"name": "prostate cancer, hereditary, 15",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "HPCX1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer, hereditary, X-linked 1",
"description": ""
},
{
"id": "MONDO:0010257",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010257",
"name": "prostate cancer susceptibility, X-linked",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "HPCX2",
"description": ""
},
{
"id": "MONDO:0010405",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0010405",
"name": "prostate cancer, hereditary, X-linked 2",
"description": ""
},
{
"id": "MIM:611868",
"resource": "MIM",
"url": "https://www.omim.org/entry/611868",
"name": "Prostate cancer, hereditary, 12",
"description": "Prostate cancer, hereditary, 12"
},
{
"id": "MIM:611928",
"resource": "MIM",
"url": "https://www.omim.org/entry/611928",
"name": "Prostate cancer, hereditary, 13",
"description": "Prostate cancer, hereditary, 13"
},
{
"id": "MIM:176807",
"resource": "MIM",
"url": "https://www.omim.org/entry/176807",
"name": "Prostate cancer",
"description": "Prostate cancer"
},
{
"id": "MIM:601518",
"resource": "MIM",
"url": "https://www.omim.org/entry/601518",
"name": "Prostate cancer, hereditary, 1",
"description": "Prostate cancer, hereditary, 1"
},
{
"id": "MIM:611955",
"resource": "MIM",
"url": "https://www.omim.org/entry/611955",
"name": "Prostate cancer, hereditary, 11",
"description": "Prostate cancer, hereditary, 11"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Stomach cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:10534",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:10534",
"recommended_name": {
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "stomach cancer",
"description": "A gastrointestinal system cancer that is located_in the stomach."
},
"synonyms": [
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric cancer",
"description": ""
},
{
"id": "DOID:10534",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:10534",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": "A primary or metastatic malignant neoplasm involving the stomach."
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca lesser curvature - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "cancer of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer risk after h. pylori infection",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumor",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant gastric tumour",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant stomach neoplasm",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumor of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of greater curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of lesser curve of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant tumour of the stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "stomach cancer",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "Ca body - stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "ca greater curvature of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "malignant neoplasm of body of stomach",
"description": ""
},
{
"id": "MONDO:0001056",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001056",
"name": "gastric cancer, intestinal",
"description": ""
},
{
"id": "MIM:613659",
"resource": "MIM",
"url": "https://www.omim.org/entry/613659",
"name": "Gastric cancer",
"description": "Gastric cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Urinary bladder cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11054",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:11054",
"recommended_name": {
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "urinary bladder cancer",
"description": "An urinary system cancer that results_in malignant growth located_in the urinary bladder."
},
"synonyms": [
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "bladder cancer",
"description": ""
},
{
"id": "DOID:11054",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11054",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": "A primary or metastatic malignant neoplasm involving the bladder."
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "bladder cancer, somatic",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "cancer of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant neoplasm, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumor, urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of the urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant tumour of urinary bladder",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "malignant urinary bladder tumour",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder cancer",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant neoplasm",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumor",
"description": ""
},
{
"id": "MONDO:0001187",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0001187",
"name": "urinary bladder malignant tumour",
"description": ""
},
{
"id": "MIM:109800",
"resource": "MIM",
"url": "https://www.omim.org/entry/109800",
"name": "Bladder cancer",
"description": "Bladder cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "up",
"name": "Head and neck cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:11934",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:11934",
"recommended_name": {
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck cancer",
"description": "An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx."
},
"synonyms": [
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head and neck tumours",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "head/neck neoplasm",
"description": ""
},
{
"id": "DOID:11934",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:11934",
"name": "tumor of head and neck",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Lung cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1324",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:1324",
"recommended_name": {
"id": "DOID:1324",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1324",
"name": "lung cancer",
"description": "A respiratory system cancer that is located_in the lung."
},
"synonyms": [
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "LNCR1",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility",
"description": ""
},
{
"id": "MONDO:0012159",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012159",
"name": "lung cancer susceptibility 1",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "LNCR3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "lung cancer susceptibility 3",
"description": ""
},
{
"id": "MONDO:0012942",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012942",
"name": "adenocarcinoma of lung, susceptibility to",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "LNCR4",
"description": ""
},
{
"id": "MONDO:0012955",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0012955",
"name": "lung cancer susceptibility 4",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "LNCR5",
"description": ""
},
{
"id": "MONDO:0013631",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0013631",
"name": "lung cancer susceptibility 5",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": "A malignant neoplasm involving the lung."
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "adenocarcinoma of lung, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "cancer of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, resistance to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung neoplasm",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumor",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant lung tumour",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant neoplasm of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumor of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "malignant tumour of the lung",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, somatic",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "Nonsmall cell lung cancer",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "alveolar cell carcinoma",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung cancer, protection against",
"description": ""
},
{
"id": "MONDO:0008903",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0008903",
"name": "lung neoplasm",
"description": ""
},
{
"id": "MIM:211980",
"resource": "MIM",
"url": "https://www.omim.org/entry/211980",
"name": "Lung cancer",
"description": "Lung cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Breast cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1612",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:1612",
"recommended_name": {
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast cancer",
"description": "A thoracic cancer that originates in the mammary gland."
},
"synonyms": [
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "breast tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant neoplasm of breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "malignant tumor of the breast",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary cancer",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "mammary tumor",
"description": ""
},
{
"id": "DOID:1612",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1612",
"name": "primary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma."
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer susceptibility, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, lobular, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, protection against, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, somatic",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "familial cancer of the breast",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast cancer",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "hereditary breast carcinoma",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial",
"description": ""
},
{
"id": "MONDO:0016419",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0016419",
"name": "breast cancer, familial Male",
"description": ""
},
{
"id": "MIM:114480",
"resource": "MIM",
"url": "https://www.omim.org/entry/114480",
"name": "Breast cancer",
"description": "Breast cancer"
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Thyroid cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:1781",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:1781",
"recommended_name": {
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid cancer",
"description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage."
},
"synonyms": [
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid gland cancer",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "Thyroid gland neoplasm",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "malignant tumour of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "neoplasm of thyroid gland",
"description": ""
},
{
"id": "DOID:1781",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:1781",
"name": "thyroid neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Kidney cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:263",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:263",
"recommended_name": {
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "kidney cancer",
"description": "A urinary system cancer that is located_in the kidney."
},
"synonyms": [
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant neoplasm of kidney except pelvis",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "malignant tumour of kidney",
"description": ""
},
{
"id": "DOID:263",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:263",
"name": "renal cancer",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Liver cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:3571",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:3571",
"recommended_name": {
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "liver cancer",
"description": "A hepatobiliary system cancer that is located_in the liver."
},
"synonyms": [
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Ca liver - primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "Resectable malignant neoplasm of Liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "hepatic neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant hepato-biliary neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, primary",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant tumor of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "non-resectable primary hepatic malignant neoplasm",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary liver cancer",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "primary malignant neoplasm of liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "resectable malignant neoplasm of the liver",
"description": ""
},
{
"id": "DOID:3571",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:3571",
"name": "malignant neoplasm of liver, not specified as primary or secondary",
"description": ""
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Uterine cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:363",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:363",
"recommended_name": {
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine cancer",
"description": "A female reproductive organ cancer that is located_in the uterus."
},
"synonyms": [
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "CA - cancer of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "Tumour of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "malignant uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "neoplasm of uterus",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterine tumor",
"description": ""
},
{
"id": "DOID:363",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:363",
"name": "uterus neoplasm",
"description": ""
}
]
}
]
},
{
"significant": "No",
"trend": "down",
"name": "Esophageal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:5041",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:5041",
"recommended_name": {
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophageal cancer",
"description": "A gastrointestinal system cancer that is located_in the esophagus."
},
"synonyms": [
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "esophagus cancer",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Distal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of Proximal Third of esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "DOID:5041",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:5041",
"name": "malignant tumor of the middle Third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": "A primary or metastatic malignant neoplasm involving the esophagus."
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "cancer of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, somatic",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophageal tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant esophagus tumor",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus neoplasm",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant oesophagus tumour",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "oesophagus cancer",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca lower third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Ca middle third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of lower third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of middle third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant neoplasm of upper third oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of abdominal esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of distal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of proximal third of esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumor of the middle third of the esophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of abdominal oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of distal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of proximal third of oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "malignant tumour of the middle third of the oesophagus",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Aerodigestive tract cancer, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "Escc, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "esophageal squamous cell carcinoma, susceptibility to",
"description": ""
},
{
"id": "MONDO:0007576",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0007576",
"name": "gastric cardia adenocarcinoma, susceptibility to",
"description": ""
},
{
"id": "MIM:133239",
"resource": "MIM",
"url": "https://www.omim.org/entry/133239",
"name": "Esophageal cancer",
"description": "Esophageal cancer"
}
]
}
]
},
{
"significant": "Yes",
"trend": "up",
"name": "Colorectal cancer [DO disease name]",
"url": "http://disease-ontology.org/term/DOID:9256",
"evidence": [
{
"database": "BioXpress",
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15357"
}
],
"disease": [
{
"disease_id": "DOID:9256",
"recommended_name": {
"id": "DOID:9256",
"resource": "Disease Ontology",
"url": "http://disease-ontology.org/term/DOID:9256",
"name": "colorectal cancer",
"description": "A large intestine cancer that is located_in the colon and/or located_in the rectum."
},
"synonyms": [
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma."
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "cancer of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, advanced, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer with chromosomal instability, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, somatic",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectal cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colorectum cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectal tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant colorectum neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large bowel tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine neoplasm",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumor",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant large intestine tumour",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of colorectum",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant neoplasm of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumor of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large bowel",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "malignant tumour of the large intestine",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "CRC",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation",
"description": ""
},
{
"id": "MONDO:0005575",
"resource": "MONDO",
"url": "https://monarchinitiative.org/disease/MONDO:0005575",
"name": "large intestine cancer",
"description": ""
},
{
"id": "MIM:114500",
"resource": "MIM",
"url": "https://www.omim.org/entry/114500",
"name": "Colorectal cancer",
"description": "Colorectal cancer"
}
]
}
]
}
],
"species": [
{
"name": "Homo sapiens",
"taxid": 9606,
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"common_name": "Human"
}
],
"gene": [
{
"name": "INPPL1",
"url": "https://www.uniprot.org/uniprot/O15357",
"locus": {
"chromosome": "11",
"start_pos": 72239147,
"end_pos": 72223701,
"strand": "-",
"evidence": [
{
"database": "Ensembl Gene",
"id": "ENSG00000165458",
"url": "https://www.ensembl.org/id/ENSG00000165458"
}
]
}
}
],
"crossref": [
{
"id": "ENSG00000165458",
"url": "https://bgee.org/?page=gene&gene_id=ENSG00000165458",
"database": "Bgee",
"categories": [
"Gene Expression"
]
},
{
"id": "O15357",
"url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15357",
"database": "BioMuta",
"categories": [
"Variation"
]
},
{
"id": "3.1.3.56",
"url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.56&UniProtAcc=O15357",
"database": "BRENDA",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "3.1.3.86",
"url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.3.86&UniProtAcc=O15357",
"database": "BRENDA",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "cd09101",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09101",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd09491",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd09491",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "cd10343",
"url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd10343",
"database": "CDD",
"categories": [
"Protein Classification"
]
},
{
"id": "CHEMBL2331064",
"url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL2331064",
"database": "ChEMBL",
"categories": [
"Other"
]
},
{
"id": "INPPL1",
"url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=INPPL1",
"database": "GeneCards",
"categories": [
"Gene Annotation",
"Organism-specific"
]
},
{
"id": "3636",
"url": "https://www.ncbi.nlm.nih.gov/gene/3636",
"database": "GeneID",
"categories": [
"Genome Annotation"
]
},
{
"id": "6080",
"url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6080",
"database": "HGNC",
"categories": [
"Organism-specific"
]
},
{
"id": "O15357",
"url": "https://www.ebi.ac.uk/intact/interactors/id:O15357*",
"database": "IntAct",
"categories": [
"Other"
]
},
{
"id": "IPR000300",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000300",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR000980",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR000980",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR001660",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR001660",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR013761",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR013761",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR036691",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR036691",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "IPR036860",
"url": "https://www.ebi.ac.uk/interpro/entry/IPR036860",
"database": "InterPro",
"categories": [
"Protein Classification"
]
},
{
"id": "hsa:3636",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3636",
"database": "KEGG Pathway",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "258480",
"url": "http://www.omim.org/entry/258480",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "600829",
"url": "http://www.omim.org/entry/600829",
"database": "MIM",
"categories": [
"Other"
]
},
{
"id": "NX_O15357",
"url": "https://www.nextprot.org/entry/NX_O15357",
"database": "neXtProt",
"categories": [
"Protein",
"Organism-specific"
]
},
{
"id": "O15357",
"url": "https://oglcnac.org/atlas/detail/O15357",
"database": "O-GlcNAc Atlas",
"categories": [
"Glycoproteomics"
]
},
{
"id": "O15357",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15357",
"database": "O-GlcNAc Database",
"categories": [
"Glycoproteomics"
]
},
{
"id": "TERMGTR",
"url": "https://omabrowser.org/oma/group/TERMGTR/",
"database": "OMA",
"categories": [
"Protein Classification"
]
},
{
"id": "21647at2759",
"url": "http://www.orthodb.org/?query=21647at2759",
"database": "OrthoDB",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR46051",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46051",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "PTHR46051:SF2",
"url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR46051:SF2",
"database": "PANTHER",
"categories": [
"Protein Classification"
]
},
{
"id": "2K4P",
"url": "https://www.rcsb.org/structure/2K4P",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2KSO",
"url": "https://www.rcsb.org/structure/2KSO",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "2MK2",
"url": "https://www.rcsb.org/structure/2MK2",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "3NR8",
"url": "https://www.rcsb.org/structure/3NR8",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "4A9C",
"url": "https://www.rcsb.org/structure/4A9C",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5OKM",
"url": "https://www.rcsb.org/structure/5OKM",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5OKN",
"url": "https://www.rcsb.org/structure/5OKN",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5OKO",
"url": "https://www.rcsb.org/structure/5OKO",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "5OKP",
"url": "https://www.rcsb.org/structure/5OKP",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6SQU",
"url": "https://www.rcsb.org/structure/6SQU",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "6SRR",
"url": "https://www.rcsb.org/structure/6SRR",
"database": "PDB",
"categories": [
"3D Structure"
]
},
{
"id": "PF00017",
"url": "http://pfam.xfam.org/family/PF00017",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "PF00536",
"url": "http://pfam.xfam.org/family/PF00536",
"database": "Pfam",
"categories": [
"Protein Classification"
]
},
{
"id": "O15357",
"url": "https://pharos.nih.gov/targets/O15357",
"database": "PHAROS",
"categories": [
"Organism-specific"
]
},
{
"id": "PR_O15357",
"url": "http://purl.obolibrary.org/obo/PR_O15357",
"database": "PRO",
"categories": [
"Protein"
]
},
{
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350",
"database": "Reactome",
"categories": [
"Protein Classification"
]
},
{
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558",
"database": "RefSeq",
"categories": [
"Protein"
]
},
{
"id": "25528",
"url": "https://www.rhea-db.org/rhea/25528",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "43548",
"url": "https://www.rhea-db.org/rhea/43548",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "43556",
"url": "https://www.rhea-db.org/rhea/43556",
"database": "Rhea",
"categories": [
"Enzyme and Pathway"
]
},
{
"id": "F5GWY9",
"url": "https://www.uniprot.org/uniprot/F5GWY9",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5GWY9-1",
"url": "https://www.uniprot.org/uniprot/F5GWY9-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5GY16",
"url": "https://www.uniprot.org/uniprot/F5GY16",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5GY16-1",
"url": "https://www.uniprot.org/uniprot/F5GY16-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5GYK9",
"url": "https://www.uniprot.org/uniprot/F5GYK9",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5GYK9-1",
"url": "https://www.uniprot.org/uniprot/F5GYK9-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5H588",
"url": "https://www.uniprot.org/uniprot/F5H588",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "F5H588-1",
"url": "https://www.uniprot.org/uniprot/F5H588-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H0YFB4",
"url": "https://www.uniprot.org/uniprot/H0YFB4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H0YFB4-1",
"url": "https://www.uniprot.org/uniprot/H0YFB4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H0YFZ4",
"url": "https://www.uniprot.org/uniprot/H0YFZ4",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H0YFZ4-1",
"url": "https://www.uniprot.org/uniprot/H0YFZ4-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H7BXR2",
"url": "https://www.uniprot.org/uniprot/H7BXR2",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "H7BXR2-1",
"url": "https://www.uniprot.org/uniprot/H7BXR2-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O15357-1",
"url": "https://www.uniprot.org/uniprot/O15357-1",
"database": "UniProtKB",
"categories": [
"Protein"
]
},
{
"id": "O15357-2",
"url": "https://www.uniprot.org/uniprot/O15357-2",
"database": "UniProtKB",
"categories": [
"Protein"
]
}
],
"sequence": {
"sequence": "MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLSTVSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAGMSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK",
"length": 1258,
"header": "sp|O15357-1|SHIP2_HUMAN Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2 CANONICAL=O15357-1"
},
"isoforms": [
{
"isoform_ac": "F5GWY9-1",
"url": "",
"sequence": {
"sequence": "MASACGAPGPGGALGSQ",
"length": 17,
"header": "tr|F5GWY9-1|F5GWY9_HUMAN Computationally mapped isoform of Inositol polyphosphate phosphatase like 1 OS=Homo sapiens OX=9606 GN=INPPL1 PE=4 SV=8 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72225035,
"end_pos": 72224985,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000543234.1",
"url": "https://www.ensembl.org/id/ENST00000543234.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000440512.1",
"url": "https://www.ensembl.org/id/ENSP00000440512.1"
}
]
}
},
{
"isoform_ac": "F5GY16-1",
"url": "",
"sequence": {
"sequence": "MVTRLLQQQALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSAR",
"length": 127,
"header": "tr|F5GY16-1|F5GY16_HUMAN Computationally mapped isoform of Inositol polyphosphate phosphatase like 1 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=1 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72230468,
"end_pos": 72229532,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000540329.5",
"url": "https://www.ensembl.org/id/ENST00000540329.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000440018.1",
"url": "https://www.ensembl.org/id/ENSP00000440018.1"
}
]
}
},
{
"isoform_ac": "F5GYK9-1",
"url": "",
"sequence": {
"sequence": "MASACGAPGPGGALGSQAPSWY",
"length": 22,
"header": "tr|F5GYK9-1|SHIP2_HUMAN Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=1 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72225050,
"end_pos": 72224985,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000540973.1",
"url": "https://www.ensembl.org/id/ENST00000540973.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000440904.1",
"url": "https://www.ensembl.org/id/ENSP00000440904.1"
}
]
}
},
{
"isoform_ac": "F5H588-1",
"url": "",
"sequence": {
"sequence": "MVTRLLQQQNLPQTGEQELESLVLKLSVLKDFL",
"length": 33,
"header": "tr|F5H588-1|F5H588_HUMAN Computationally mapped isoform of Inositol polyphosphate phosphatase like 1 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=8 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72229734,
"end_pos": 72229532,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000537656.1",
"url": "https://www.ensembl.org/id/ENST00000537656.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000444630.1",
"url": "https://www.ensembl.org/id/ENSP00000444630.1"
}
]
}
},
{
"isoform_ac": "H0YFB4-1",
"url": "",
"sequence": {
"sequence": "XTIPPCLGHLRLELPPSSSPRKGSQRLQTRPTLSLRASRPL",
"length": 41,
"header": "tr|H0YFB4-1|SHIP2_HUMAN Computationally mapped isoform of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=1 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72234338,
"end_pos": 72233680,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000535985.1",
"url": "https://www.ensembl.org/id/ENST00000535985.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000437852.1",
"url": "https://www.ensembl.org/id/ENSP00000437852.1"
}
]
}
},
{
"isoform_ac": "H0YFZ4-1",
"url": "",
"sequence": {
"sequence": "VLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEE",
"length": 197,
"header": "tr|H0YFZ4-1|H0YFZ4_HUMAN Computationally mapped isoform of Inositol polyphosphate phosphatase like 1 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=1 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72237796,
"end_pos": 72237206,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000541752.1",
"url": "https://www.ensembl.org/id/ENST00000541752.1"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000441094.1",
"url": "https://www.ensembl.org/id/ENSP00000441094.1"
}
]
}
},
{
"isoform_ac": "H7BXR2-1",
"url": "",
"sequence": {
"sequence": "XPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAGMSAWLRAIGLERYEEGLVHNGWDDLEFLRWGRGWPRGRSWGPQDPLAHLTSQPVLLHSDITEEDLEEAGVQDPAHKRLLLDTLQLSK",
"length": 149,
"header": "tr|H7BXR2-1|H7BXR2_HUMAN Computationally mapped isoform of Inositol polyphosphate phosphatase like 1 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=1 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72238351,
"end_pos": 72237660,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000320683.7",
"url": "https://www.ensembl.org/id/ENST00000320683.7"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000321775.7",
"url": "https://www.ensembl.org/id/ENSP00000321775.7"
}
]
}
},
{
"isoform_ac": "O15357-1",
"url": "",
"sequence": {
"sequence": "MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLSTVSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAGMSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK",
"length": 1258,
"header": "sp|O15357-1|SHIP2_HUMAN Isoform 1 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72238350,
"end_pos": 72224985,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000298229.7",
"url": "https://www.ensembl.org/id/ENST00000298229.7"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000298229.2",
"url": "https://www.ensembl.org/id/ENSP00000298229.2"
}
]
}
},
{
"isoform_ac": "O15357-2",
"url": "",
"sequence": {
"sequence": "MVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAGMSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK",
"length": 1016,
"header": "sp|O15357-2|SHIP2_HUMAN Isoform 2 of Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2 CANONICAL=O15357-1"
},
"locus": {
"chromosome": "11",
"start_pos": 72238350,
"end_pos": 72229532,
"strand": "-",
"evidence": [
{
"database": "Ensembl Transcript",
"id": "ENST00000538751.5",
"url": "https://www.ensembl.org/id/ENST00000538751.5"
},
{
"database": "Ensembl Peptide",
"id": "ENSP00000444619.1",
"url": "https://www.ensembl.org/id/ENSP00000444619.1"
}
]
}
}
],
"glycosylation": [
{
"glytoucan_ac": "G49108TO",
"type": "O-linked",
"subtype": "O-GlcNAcylation",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "O-GlcNAcylation",
"start_pos": 276,
"start_aa": "Ser",
"end_pos": 276,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser276",
"evidence": [
{
"id": "O15357",
"database": "O-GlcNAc Database",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15357"
},
{
"id": "23301498",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/23301498"
},
{
"id": "30379171",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/30379171"
},
{
"id": "35132862",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/35132862"
},
{
"id": "29351928",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29351928"
},
{
"id": "O15357",
"database": "O-GlcNAc Atlas",
"url": "https://oglcnac.org/atlas/detail/O15357"
}
]
},
{
"glytoucan_ac": "G70994MS",
"type": "O-linked",
"subtype": "",
"site_category": "reported_with_glycan",
"site_seq": "S",
"relation": "attached",
"comment": "",
"start_pos": 276,
"start_aa": "Ser",
"end_pos": 276,
"end_aa": "Ser",
"residue": "Ser",
"site_lbl": "Ser276",
"evidence": [
{
"id": "GLY_000142",
"database": "GlyGen",
"url": "https://data.glygen.org/GLY_000142"
},
{
"id": "29351928",
"database": "PubMed",
"url": "https://glygen.org/publication/PubMed/29351928"
}
]
}
],
"phosphorylation": [
{
"start_pos": 1003,
"end_pos": 1003,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "PubMed",
"id": "19901323",
"url": "https://glygen.org/publication/PubMed/19901323"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
},
{
"database": "PubMed",
"id": "15951569",
"url": "https://glygen.org/publication/PubMed/15951569"
},
{
"database": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
}
],
"site_lbl": "Ser1003"
},
{
"start_pos": 1038,
"end_pos": 1038,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser1038"
},
{
"start_pos": 1039,
"end_pos": 1039,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser1039"
},
{
"start_pos": 1061,
"end_pos": 1061,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser1061"
},
{
"start_pos": 1068,
"end_pos": 1068,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser1068"
},
{
"start_pos": 1131,
"end_pos": 1131,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"site_lbl": "Ser1131"
},
{
"start_pos": 1135,
"end_pos": 1135,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "Phosphotyrosine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "PubMed",
"id": "16497976",
"url": "https://glygen.org/publication/PubMed/16497976"
},
{
"database": "PubMed",
"id": "17389395",
"url": "https://glygen.org/publication/PubMed/17389395"
},
{
"database": "PubMed",
"id": "19901323",
"url": "https://glygen.org/publication/PubMed/19901323"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
},
{
"database": "PubMed",
"id": "22194892",
"url": "https://glygen.org/publication/PubMed/22194892"
},
{
"database": "PubMed",
"id": "24561238",
"url": "https://glygen.org/publication/PubMed/24561238"
}
],
"site_lbl": "Tyr1135"
},
{
"start_pos": 1162,
"end_pos": 1162,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "Phosphotyrosine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "PubMed",
"id": "11687594",
"url": "https://glygen.org/publication/PubMed/11687594"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "PubMed",
"id": "16497976",
"url": "https://glygen.org/publication/PubMed/16497976"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Tyr1162"
},
{
"start_pos": 1257,
"end_pos": 1257,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"site_lbl": "Ser1257"
},
{
"start_pos": 132,
"end_pos": 132,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "18452278",
"url": "https://glygen.org/publication/PubMed/18452278"
},
{
"database": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
},
{
"database": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
},
{
"database": "PubMed",
"id": "21770892",
"url": "https://glygen.org/publication/PubMed/21770892"
}
],
"site_lbl": "Ser132"
},
{
"start_pos": 158,
"end_pos": 158,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Ser158"
},
{
"start_pos": 165,
"end_pos": 165,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "Phosphothreonine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Thr165"
},
{
"start_pos": 167,
"end_pos": 167,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Thr167"
},
{
"start_pos": 240,
"end_pos": 240,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
],
"site_lbl": "Ser240"
},
{
"start_pos": 241,
"end_pos": 241,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Ser241"
},
{
"start_pos": 290,
"end_pos": 290,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser290"
},
{
"start_pos": 291,
"end_pos": 291,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser291"
},
{
"start_pos": 352,
"end_pos": 352,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"site_lbl": "Ser352"
},
{
"start_pos": 671,
"end_pos": 671,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Tyr671"
},
{
"start_pos": 827,
"end_pos": 827,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "32387766",
"url": ""
}
],
"site_lbl": "Ser827"
},
{
"start_pos": 886,
"end_pos": 886,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "Phosphotyrosine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "PubMed",
"id": "17389395",
"url": "https://glygen.org/publication/PubMed/17389395"
},
{
"database": "PubMed",
"id": "19901323",
"url": "https://glygen.org/publication/PubMed/19901323"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
},
{
"database": "PubMed",
"id": "15592455",
"url": "https://glygen.org/publication/PubMed/15592455"
}
],
"site_lbl": "Tyr886"
},
{
"start_pos": 890,
"end_pos": 890,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Ser",
"comment": "Phosphoserine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
],
"site_lbl": "Ser890"
},
{
"start_pos": 958,
"end_pos": 958,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Thr",
"comment": "Phosphothreonine",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "17219406",
"url": "https://glygen.org/publication/PubMed/17219406"
},
{
"database": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"site_lbl": "Thr958"
},
{
"start_pos": 986,
"end_pos": 986,
"kinase_uniprot_canonical_ac": "P12931-1",
"kinase_gene_name": "SRC",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
},
{
"database": "PubMed",
"id": "16497976",
"url": "https://glygen.org/publication/PubMed/16497976"
},
{
"database": "PubMed",
"id": "17389395",
"url": "https://glygen.org/publication/PubMed/17389395"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PubMed",
"id": "19901323",
"url": "https://glygen.org/publication/PubMed/19901323"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Tyr986"
},
{
"start_pos": 986,
"end_pos": 986,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "Phosphotyrosine; by SRC",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
},
{
"database": "PubMed",
"id": "15592455",
"url": "https://glygen.org/publication/PubMed/15592455"
},
{
"database": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
},
{
"database": "PubMed",
"id": "18083107",
"url": "https://glygen.org/publication/PubMed/18083107"
},
{
"database": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
},
{
"database": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
},
{
"database": "PubMed",
"id": "11349134",
"url": "https://glygen.org/publication/PubMed/11349134"
}
],
"site_lbl": "Tyr986"
},
{
"start_pos": 987,
"end_pos": 987,
"kinase_uniprot_canonical_ac": "P12931-1",
"kinase_gene_name": "SRC",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
},
{
"database": "PubMed",
"id": "16497976",
"url": "https://glygen.org/publication/PubMed/16497976"
},
{
"database": "phospho.ELM",
"id": "O15357",
"url": "http://phospho.elm.eu.org/byAccession/O15357.html"
}
],
"site_lbl": "Tyr987"
},
{
"start_pos": 987,
"end_pos": 987,
"kinase_uniprot_canonical_ac": "",
"kinase_gene_name": "",
"residue": "Tyr",
"comment": "",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
},
{
"database": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
}
],
"site_lbl": "Tyr987"
}
],
"glycation": [],
"keywords": [
"enzyme",
"glycoprotein",
"glycoprotein_reported_with_glycan"
],
"publication": [
{
"title": "A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.",
"journal": "Blood",
"date": "1999",
"authors": "Wisniewski D, Strife A, Swendeman S, Erdjument-Bromage H, Geromanos S, Kavanaugh WM, Tempst P, Clarkson B",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10194451",
"url": "https://glygen.org/publication/PubMed/10194451"
}
]
},
{
"title": "The src homology domain 2-containing inositol phosphatase SHIP forms a ternary complex with Shc and Grb2 in antigen receptor-stimulated B lymphocytes.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Harmer SL, DeFranco AL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "10207047",
"url": "https://glygen.org/publication/PubMed/10207047"
}
]
},
{
"title": "SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Guo S, Stolz LE, Lemrow SM, York JD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10224048",
"url": "https://glygen.org/publication/PubMed/10224048"
}
]
},
{
"title": "Engagement of Gab1 and Gab2 in erythropoietin signaling.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, Sawyer ST, Krystal G, Yi T, Nishada K, Hibi M, Hirano T, Platanias LC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "10455108",
"url": "https://glygen.org/publication/PubMed/10455108"
}
]
},
{
"title": "Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association.",
"journal": "Cell",
"date": "1999",
"authors": "Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P, Pavletich NP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10555148",
"url": "https://glygen.org/publication/PubMed/10555148"
}
]
},
{
"title": "ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex.",
"journal": "Nature cell biology",
"date": "1999",
"authors": "Godi A, Pertile P, Meyers R, Marra P, Di Tullio G, Iurisci C, Luini A, Corda D, De Matteis MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10559940",
"url": "https://glygen.org/publication/PubMed/10559940"
}
]
},
{
"title": "Tyrosine phosphorylation of shc in response to B cell antigen receptor engagement depends on the SHIP inositol phosphatase.",
"journal": "Journal of immunology (Baltimore, Md. : 1950)",
"date": "1999",
"authors": "Ingham RJ, Okada H, Dang-Lawson M, Dinglasan J, van Der Geer P, Kurosaki T, Gold MR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "10570274",
"url": "https://glygen.org/publication/PubMed/10570274"
}
]
},
{
"title": "Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles.",
"journal": "The Journal of biological chemistry",
"date": "1999",
"authors": "Mochizuki Y, Takenawa T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10593988",
"url": "https://glygen.org/publication/PubMed/10593988"
}
]
},
{
"title": "Identification and characterization of a novel inositol polyphosphate 5-phosphatase.",
"journal": "The Journal of biological chemistry",
"date": "2000",
"authors": "Ijuin T, Mochizuki Y, Fukami K, Funaki M, Asano T, Takenawa T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10753883",
"url": "https://glygen.org/publication/PubMed/10753883"
}
]
},
{
"title": "Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors.",
"journal": "Molecular and cellular biology",
"date": "2000",
"authors": "Arcaro A, Zvelebil MJ, Wallasch C, Ullrich A, Waterfield MD, Domin J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10805725",
"url": "https://glygen.org/publication/PubMed/10805725"
}
]
},
{
"title": "The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.",
"journal": "Cellular signalling",
"date": "2000",
"authors": "Dunant NM, Wisniewski D, Strife A, Clarkson B, Resh MD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "10822173",
"url": "https://glygen.org/publication/PubMed/10822173"
}
]
},
{
"title": "Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.",
"journal": "Cancer research",
"date": "2000",
"authors": "Han SY, Kato H, Kato S, Suzuki T, Shibata H, Ishii S, Shiiba K, Matsuno S, Kanamaru R, Ishioka C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "10866302",
"url": "https://glygen.org/publication/PubMed/10866302"
}
]
},
{
"title": "New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway.",
"journal": "Molecular and cellular biology",
"date": "2000",
"authors": "Gu H, Maeda H, Moon JJ, Lord JD, Yoakim M, Nelson BH, Neel BG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "10982827",
"url": "https://glygen.org/publication/PubMed/10982827"
}
]
},
{
"title": "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.",
"journal": "The Biochemical journal",
"date": "2000",
"authors": "Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11001876",
"url": "https://glygen.org/publication/PubMed/11001876"
}
]
},
{
"title": "Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.",
"journal": "The Journal of biological chemistry",
"date": "2000-12-01",
"authors": "Bruhns P, Vely F, Malbec O, Fridman W H, Vivier E, Daeron M",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "11016922",
"url": "https://glygen.org/publication/PubMed/11016922"
}
]
},
{
"title": "A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Lopez I, Mak EC, Ding J, Hamm HE, Lomasney JW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11022047",
"url": "https://glygen.org/publication/PubMed/11022047"
}
]
},
{
"title": "Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Song C, Hu CD, Masago M, Kariyai K, Yamawaki-Kataoka Y, Shibatohge M, Wu D, Satoh T, Kataoka T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11022048",
"url": "https://glygen.org/publication/PubMed/11022048"
}
]
},
{
"title": "Multitasking in signal transduction by a promiscuous human Ins(3,4,5,6)P(4) 1-kinase/Ins(1,3,4)P(3) 5/6-kinase.",
"journal": "The Biochemical journal",
"date": "2000",
"authors": "Yang X, Shears SB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11042108",
"url": "https://glygen.org/publication/PubMed/11042108"
}
]
},
{
"title": "Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis.",
"journal": "Current biology : CB",
"date": "2000",
"authors": "Malecz N, McCabe PC, Spaargaren C, Qiu R, Chuang Y, Symons M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11084340",
"url": "https://glygen.org/publication/PubMed/11084340"
}
]
},
{
"title": "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1).",
"journal": "Biochimica et biophysica acta",
"date": "2000",
"authors": "Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11118617",
"url": "https://glygen.org/publication/PubMed/11118617"
}
]
},
{
"title": "SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading.",
"journal": "Molecular and cellular biology",
"date": "2001",
"authors": "Prasad N, Topping RS, Decker SJ",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "11158326",
"url": "https://glygen.org/publication/PubMed/11158326"
}
]
},
{
"title": "Cloning of a human type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Minogue S, Anderson JS, Waugh MG, dos Santos M, Corless S, Cramer R, Hsuan JJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11279162",
"url": "https://glygen.org/publication/PubMed/11279162"
}
]
},
{
"title": "FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate.",
"journal": "Experimental cell research",
"date": "2001",
"authors": "Zhao R, Qi Y, Chen J, Zhao ZJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11302699",
"url": "https://glygen.org/publication/PubMed/11302699"
}
]
},
{
"title": "Gab2 is phosphorylated on tyrosine upon interleukin-2/interleukin-15 stimulation in mycosis-fungoides-derived tumor T cells and associates inducibly with SHP-2 and Stat5a.",
"journal": "Experimental and clinical immunogenetics",
"date": "2001",
"authors": "Brockdorff JL, Gu H, Mustelin T, Kaltoft K, Geisler C, Ropke C, Odum N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "11340297",
"url": "https://glygen.org/publication/PubMed/11340297"
}
]
},
{
"title": "The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.",
"journal": "The Journal of biological chemistry",
"date": "2001",
"authors": "Pesesse X, Dewaste V, De Smedt F, Laffargue M, Giuriato S, Moreau C, Payrastre B, Erneux C",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "11349134",
"url": "https://glygen.org/publication/PubMed/11349134"
}
]
},
{
"title": "PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse.",
"journal": "Neuron",
"date": "2001",
"authors": "Wenk MR, Pellegrini L, Klenchin VA, Di Paolo G, Chang S, Daniell L, Arioka M, Martin TF, De Camilli P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11604140",
"url": "https://glygen.org/publication/PubMed/11604140"
}
]
},
{
"title": "Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity.",
"journal": "Current biology : CB",
"date": "2001",
"authors": "Walker DM, Urbe S, Dove SK, Tenza D, Raposo G, Clague MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11676921",
"url": "https://glygen.org/publication/PubMed/11676921"
}
]
},
{
"title": "Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Steen H, Kuster B, Fernandez M, Pandey A, Mann M",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "11687594",
"url": "https://glygen.org/publication/PubMed/11687594"
}
]
},
{
"title": "Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Kim SA, Taylor GS, Torgersen KM, Dixon JE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11733541",
"url": "https://glygen.org/publication/PubMed/11733541"
}
]
},
{
"title": "The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.",
"journal": "The Journal of cell biology",
"date": "2001-12-10",
"authors": "Dyson J M, O'Malley C J, Becanovic J, Munday A D, Berndt M C, Coghill I D, Nandurkar H H, Ooms L M, Mitchell C A",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "11739414",
"url": "https://glygen.org/publication/PubMed/11739414"
}
]
},
{
"title": "Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Yang J, Kim O, Wu J, Qiu Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11877430",
"url": "https://glygen.org/publication/PubMed/11877430"
}
]
},
{
"title": "Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase.",
"journal": "Current biology : CB",
"date": "2002",
"authors": "Ho MW, Yang X, Carew MA, Zhang T, Hua L, Kwon YU, Chung SK, Adelt S, Vogel G, Riley AM, Potter BV, Shears SB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "11909533",
"url": "https://glygen.org/publication/PubMed/11909533"
}
]
},
{
"title": "Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Balla A, Tuymetova G, Barshishat M, Geiszt M, Balla T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "11923287",
"url": "https://glygen.org/publication/PubMed/11923287"
}
]
},
{
"title": "TAPP1 and TAPP2 are targets of phosphatidylinositol 3-kinase signaling in B cells: sustained plasma membrane recruitment triggered by the B-cell antigen receptor.",
"journal": "Molecular and cellular biology",
"date": "2002",
"authors": "Marshall AJ, Krahn AK, Ma K, Duronio V, Hou S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12101241",
"url": "https://glygen.org/publication/PubMed/12101241"
}
]
},
{
"title": "The PtdIns3P phosphatase myotubularin is a cytoplasmic protein that also localizes to Rac1-inducible plasma membrane ruffles.",
"journal": "Journal of cell science",
"date": "2002",
"authors": "Laporte J, Blondeau F, Gansmuller A, Lutz Y, Vonesch JL, Mandel JL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12118066",
"url": "https://glygen.org/publication/PubMed/12118066"
}
]
},
{
"title": "The human homolog of the rat inositol phosphate multikinase is an inositol 1,3,4,6-tetrakisphosphate 5-kinase.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Chang SC, Miller AL, Feng Y, Wente SR, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "12223481",
"url": "https://glygen.org/publication/PubMed/12223481"
}
]
},
{
"title": "Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I.",
"journal": "Journal of cell science",
"date": "2002",
"authors": "Prasad N, Topping RS, Decker SJ",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
}
]
},
{
"title": "Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.",
"journal": "The Journal of biological chemistry",
"date": "2002",
"authors": "Wei YJ, Sun HQ, Yamamoto M, Wlodarski P, Kunii K, Martinez M, Barylko B, Albanesi JP, Yin HL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12324459",
"url": "https://glygen.org/publication/PubMed/12324459"
}
]
},
{
"title": "Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin.",
"journal": "Nature",
"date": "2002",
"authors": "Di Paolo G, Pellegrini L, Letinic K, Cestra G, Zoncu R, Voronov S, Chang S, Guo J, Wenk MR, De Camilli P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12422219",
"url": "https://glygen.org/publication/PubMed/12422219"
}
]
},
{
"title": "The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.",
"journal": "Biochem. Biophys. Res. Commun.",
"date": "2003",
"authors": "Vandenbroere Isabelle, Paternotte Nathalie, Dumont Jacques E, Erneux Christophe, Pirson Isabelle",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "12504111",
"url": "https://glygen.org/publication/PubMed/12504111"
}
]
},
{
"title": "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2003",
"authors": "Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "12522270",
"url": "https://glygen.org/publication/PubMed/12522270"
}
]
},
{
"title": "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Gurung R, Tan A, Ooms LM, McGrath MJ, Huysmans RD, Munday AD, Prescott M, Whisstock JC, Mitchell CA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12536145",
"url": "https://glygen.org/publication/PubMed/12536145"
}
]
},
{
"title": "Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.",
"journal": "Current biology : CB",
"date": "2003",
"authors": "Schaletzky J, Dove SK, Short B, Lorenzo O, Clague MJ, Barr FA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12646134",
"url": "https://glygen.org/publication/PubMed/12646134"
}
]
},
{
"title": "SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton.",
"journal": "Blood",
"date": "2003-08-01",
"authors": "Dyson Jennifer M, Munday Adam D, Kong Anne M, Huysmans Richard D, Matzaris Maria, Layton Meredith J, Nandurkar Harshal H, Berndt Michael C, Mitchell Christina A",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "12676785",
"url": "https://glygen.org/publication/PubMed/12676785"
}
]
},
{
"title": "SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Pengal RA, Ganesan LP, Fang H, Marsh CB, Anderson CL, Tridandapani S",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "12690104",
"url": "https://glygen.org/publication/PubMed/12690104"
}
]
},
{
"title": "The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells.",
"journal": "The Biochemical journal",
"date": "2003",
"authors": "Dewaste V, Moreau C, De Smedt F, Bex F, De Smedt H, Wuytack F, Missiaen L, Erneux C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "12747803",
"url": "https://glygen.org/publication/PubMed/12747803"
}
]
},
{
"title": "Membrane-binding and activation mechanism of PTEN.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2003",
"authors": "Das S, Dixon JE, Cho W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12808147",
"url": "https://glygen.org/publication/PubMed/12808147"
}
]
},
{
"title": "ARF6 stimulates clathrin/AP-2 recruitment to synaptic membranes by activating phosphatidylinositol phosphate kinase type Igamma.",
"journal": "The Journal of cell biology",
"date": "2003",
"authors": "Krauss M, Kinuta M, Wenk MR, De Camilli P, Takei K, Haucke V",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "12847086",
"url": "https://glygen.org/publication/PubMed/12847086"
}
]
},
{
"title": "The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.",
"journal": "The Journal of biological chemistry",
"date": "2003",
"authors": "Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "12882960",
"url": "https://glygen.org/publication/PubMed/12882960"
}
]
},
{
"title": "Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily.",
"journal": "European journal of biochemistry",
"date": "1992",
"authors": "Carozzi AJ, Kriz RW, Webster C, Parker PJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "1333955",
"url": "https://glygen.org/publication/PubMed/1333955"
}
]
},
{
"title": "Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.",
"journal": "The EMBO journal",
"date": "1992",
"authors": "Nakamura T, Lin LL, Kharbanda S, Knopf J, Kufe D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "1334462",
"url": "https://glygen.org/publication/PubMed/1334462"
}
]
},
{
"title": "Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1.",
"journal": "The Biochemical journal",
"date": "2003",
"authors": "Kimber WA, Deak M, Prescott AR, Alessi DR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "14516276",
"url": "https://glygen.org/publication/PubMed/14516276"
}
]
},
{
"title": "Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomes.",
"journal": "Molecular biology of the cell",
"date": "2004",
"authors": "Fouraux MA, Deneka M, Ivan V, van der Heijden A, Raymackers J, van Suylekom D, van Venrooij WJ, van der Sluijs P, Pruijn GJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "14617813",
"url": "https://glygen.org/publication/PubMed/14617813"
}
]
},
{
"title": "Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases.",
"journal": "Nature",
"date": "1992",
"authors": "Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, Schlessinger J, Pawson T, et al.",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "1465135",
"url": "https://glygen.org/publication/PubMed/1465135"
}
]
},
{
"title": "Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Tronchere H, Laporte J, Pendaries C, Chaussade C, Liaubet L, Pirola L, Mandel JL, Payrastre B",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "14660569",
"url": "https://glygen.org/publication/PubMed/14660569"
}
]
},
{
"title": "The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Lee SB, Varnai P, Balla A, Jalink K, Rhee SG, Balla T",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15037625",
"url": "https://glygen.org/publication/PubMed/15037625"
}
]
},
{
"title": "InsP3-mediated intracellular calcium signalling is altered by expression of synaptojanin-1.",
"journal": "The Biochemical journal",
"date": "2004",
"authors": "Johenning FW, Wenk MR, Uhlen P, Degray B, Lee E, De Camilli P, Ehrlich BE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "15080793",
"url": "https://glygen.org/publication/PubMed/15080793"
}
]
},
{
"title": "FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.",
"journal": "Nature cell biology",
"date": "2004",
"authors": "Godi A, Di Campli A, Konstantakopoulos A, Di Tullio G, Alessi DR, Kular GS, Daniele T, Marra P, Lucocq JM, De Matteis MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "15107860",
"url": "https://glygen.org/publication/PubMed/15107860"
}
]
},
{
"title": "Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.",
"journal": "Protein expression and purification",
"date": "2004",
"authors": "Meier TI, Cook JA, Thomas JE, Radding JA, Horn C, Lingaraj T, Smith MC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "15135396",
"url": "https://glygen.org/publication/PubMed/15135396"
}
]
},
{
"title": "Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells.",
"journal": "Molecular cancer",
"date": "2004",
"authors": "Leung DW, Tompkins C, Brewer J, Ball A, Coon M, Morris V, Waggoner D, Singer JW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15140260",
"url": "https://glygen.org/publication/PubMed/15140260"
}
]
},
{
"title": "Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.",
"journal": "Diabetes",
"date": "2004",
"authors": "Kaisaki Pamela J, Del\u00e9pine Marc, Woon Peng Y, Sebag-Montefiore Liam, Wilder Steven P, Menzel Stephan, Vionnet Nathalie, Marion Evelyne, Riveline Jean-Pierre, Charpentier Guillaume, Schurmans St\u00e9phane, Levy Jonathan C, Lathrop Mark, Farrall Martin, Gauguier Dominique",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "15220217",
"url": "https://glygen.org/publication/PubMed/15220217"
}
]
},
{
"title": "Comparative mechanistic and substrate specificity study of inositol polyphosphate 5-phosphatase Schizosaccharomyces pombe Synaptojanin and SHIP2.",
"journal": "The Journal of biological chemistry",
"date": "2004",
"authors": "Chi Y, Zhou B, Wang WQ, Chung SK, Kwon YU, Ahn YH, Chang YT, Tsujishita Y, Hurley JH, Zhang ZY",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15316017",
"url": "https://glygen.org/publication/PubMed/15316017"
}
]
},
{
"title": "Regulation and cellular roles of phosphoinositide 5-kinases.",
"journal": "European journal of pharmacology",
"date": "2004",
"authors": "Oude Weernink PA, Schmidt M, Jakobs KH",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "15464023",
"url": "https://glygen.org/publication/PubMed/15464023"
}
]
},
{
"title": "Type II phosphoinositide 5-phosphatases have unique sensitivities towards fatty acid composition and head group phosphorylation.",
"journal": "FEBS letters",
"date": "2004",
"authors": "Schmid AC, Wise HM, Mitchell CA, Nussbaum R, Woscholski R",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15474001",
"url": "https://glygen.org/publication/PubMed/15474001"
}
]
},
{
"title": "Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes.",
"journal": "Reproduction (Cambridge, England)",
"date": "2004",
"authors": "Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15579586",
"url": "https://glygen.org/publication/PubMed/15579586"
}
]
},
{
"title": "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.",
"journal": "Nat. Biotechnol.",
"date": "2005",
"authors": "Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "15592455",
"url": "https://glygen.org/publication/PubMed/15592455"
}
]
},
{
"title": "SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor.",
"journal": "The Journal of biological chemistry",
"date": "2005-04-01",
"authors": "Prasad Nagendra K, Decker Stuart J",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "15668240",
"url": "https://glygen.org/publication/PubMed/15668240"
}
]
},
{
"title": "Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.",
"journal": "J. Clin. Endocrinol. Metab.",
"date": "2005",
"authors": "Kagawa S, Sasaoka T, Yaguchi S, Ishihara H, Tsuneki H, Murakami S, Fukui K, Wada T, Kobayashi S, Kimura I, Kobayashi M",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "15687335",
"url": "https://glygen.org/publication/PubMed/15687335"
}
]
},
{
"title": "Molecular cloning and characterization of a novel phospholipase C, PLC-eta.",
"journal": "The Biochemical journal",
"date": "2005",
"authors": "Hwang JI, Oh YS, Shin KJ, Kim H, Ryu SH, Suh PG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15702972",
"url": "https://glygen.org/publication/PubMed/15702972"
}
]
},
{
"title": "The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.",
"journal": "Molecular biology of the cell",
"date": "2005",
"authors": "Ivetac I, Munday AD, Kisseleva MV, Zhang XM, Luff S, Tiganis T, Whisstock JC, Rowe T, Majerus PW, Mitchell CA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "15716355",
"url": "https://glygen.org/publication/PubMed/15716355"
}
]
},
{
"title": "The SH2-domian-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading.",
"journal": "Oncogene",
"date": "2005",
"authors": "Koch A, Mancini A, El Bounkari O, Tamura T",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "15735664",
"url": "https://glygen.org/publication/PubMed/15735664"
}
]
},
{
"title": "The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Kouchi Z, Shikano T, Nakamura Y, Shirakawa H, Fukami K, Miyazaki S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "15790568",
"url": "https://glygen.org/publication/PubMed/15790568"
}
]
},
{
"title": "p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma.",
"journal": "Current biology : CB",
"date": "2005",
"authors": "Suire S, Coadwell J, Ferguson GJ, Davidson K, Hawkins P, Stephens L",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "15797027",
"url": "https://glygen.org/publication/PubMed/15797027"
}
]
},
{
"title": "Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3.",
"journal": "Journal of cell science",
"date": "2005",
"authors": "Lorenzo O, Urbe S, Clague MJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "15840652",
"url": "https://glygen.org/publication/PubMed/15840652"
}
]
},
{
"title": "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.",
"journal": "Molecular & cellular proteomics : MCP",
"date": "2005",
"authors": "Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "15951569",
"url": "https://glygen.org/publication/PubMed/15951569"
}
]
},
{
"title": "Molecular cloning and characterization of PLC-eta2.",
"journal": "The Biochemical journal",
"date": "2005",
"authors": "Zhou Y, Wing MR, Sondek J, Harden TK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "16107206",
"url": "https://glygen.org/publication/PubMed/16107206"
}
]
},
{
"title": "Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking.",
"journal": "The Journal of biological chemistry",
"date": "2005",
"authors": "Larance M, Ramm G, Stockli J, van Dam EM, Winata S, Wasinger V, Simpson F, Graham M, Junutula JR, Guilhaus M, James DE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "16154996",
"url": "https://glygen.org/publication/PubMed/16154996"
}
]
},
{
"title": "SHIP2 interaction with the cytoskeletal protein Vinexin.",
"journal": "FEBS J.",
"date": "2005",
"authors": "Paternotte Nathalie, Zhang Jing, Vandenbroere Isabelle, Backers Katrien, Blero Daniel, Kioka Noriyuki, Vanderwinden Jean-Marie, Pirson Isabelle, Erneux Christophe",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "16302969",
"url": "https://glygen.org/publication/PubMed/16302969"
}
]
},
{
"title": "Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2.",
"journal": "Human molecular genetics",
"date": "2006",
"authors": "Berger P, Berger I, Schaffitzel C, Tersar K, Volkmer B, Suter U",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "16399794",
"url": "https://glygen.org/publication/PubMed/16399794"
}
]
},
{
"title": "Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.",
"journal": "The Journal of biological chemistry",
"date": "1992",
"authors": "Park D, Jhon DY, Kriz R, Knopf J, Rhee SG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "1644792",
"url": "https://glygen.org/publication/PubMed/1644792"
}
]
},
{
"title": "Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.",
"journal": "The Journal of biological chemistry",
"date": "2006",
"authors": "Voigt P, Dorner MB, Schaefer M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "16476736",
"url": "https://glygen.org/publication/PubMed/16476736"
}
]
},
{
"title": "A common phosphotyrosine signature for the Bcr-Abl kinase.",
"journal": "Blood",
"date": "2006",
"authors": "Goss VL, Lee KA, Moritz A, Nardone J, Spek EJ, MacNeill J, Rush J, Comb MJ, Polakiewicz RD",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "16497976",
"url": "https://glygen.org/publication/PubMed/16497976"
}
]
},
{
"title": "The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.",
"journal": "Journal of cell science",
"date": "2006",
"authors": "Mari M, Monzo P, Kaddai V, Keslair F, Gonzalez T, Le Marchand-Brustel Y, Cormont M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "16522682",
"url": "https://glygen.org/publication/PubMed/16522682"
}
]
},
{
"title": "The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity.",
"journal": "Cellular signalling",
"date": "2006-12",
"authors": "Vandeput Fabrice, Backers Katrien, Villeret Vincent, Pesesse Xavier, Erneux Christophe",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "16824732",
"url": "https://glygen.org/publication/PubMed/16824732"
}
]
},
{
"title": "Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain.",
"journal": "The Journal of biological chemistry",
"date": "2006",
"authors": "Choudhury P, Srivastava S, Li Z, Ko K, Albaqumi M, Narayan K, Coetzee WA, Lemmon MA, Skolnik EY",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "16914545",
"url": "https://glygen.org/publication/PubMed/16914545"
}
]
},
{
"title": "A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis.",
"journal": "Current biology : CB",
"date": "2006",
"authors": "Halstead JR, van Rheenen J, Snel MH, Meeuws S, Mohammed S, D'Santos CS, Heck AJ, Jalink K, Divecha N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "16979564",
"url": "https://glygen.org/publication/PubMed/16979564"
}
]
},
{
"title": "A novel PtdIns3P and PtdIns(3,5)P2 phosphatase with an inactivating variant in centronuclear myopathy.",
"journal": "Human molecular genetics",
"date": "2006",
"authors": "Tosch V, Rohde HM, Tronchere H, Zanoteli E, Monroy N, Kretz C, Dondaine N, Payrastre B, Mandel JL, Laporte J",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "17008356",
"url": "https://glygen.org/publication/PubMed/17008356"
}
]
},
{
"title": "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.",
"journal": "Cell",
"date": "2006",
"authors": "Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "17081983",
"url": "https://glygen.org/publication/PubMed/17081983"
}
]
},
{
"title": "Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.",
"journal": "The Journal of biological chemistry",
"date": "2007-01-26",
"authors": "Zhuang Guanglei, Hunter Sonja, Hwang Yoonha, Chen Jin",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "17135240",
"url": "https://glygen.org/publication/PubMed/17135240"
}
]
},
{
"title": "Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.",
"journal": "The Journal of biological chemistry",
"date": "1991",
"authors": "Ross TS, Jefferson AB, Mitchell CA, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "1718960",
"url": "https://glygen.org/publication/PubMed/1718960"
}
]
},
{
"title": "Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes.",
"journal": "Journal of cellular physiology",
"date": "2007",
"authors": "Artemenko Y, Gagnon A, Ibrahim S, Sorisky A",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "17219406",
"url": "https://glygen.org/publication/PubMed/17219406"
}
]
},
{
"title": "Phospholipase D signaling: orchestration by PIP2 and small GTPases.",
"journal": "Naunyn-Schmiedeberg's archives of pharmacology",
"date": "2007",
"authors": "Oude Weernink PA, Lopez de Jesus M, Schmidt M",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "17245604",
"url": "https://glygen.org/publication/PubMed/17245604"
}
]
},
{
"title": "The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.",
"journal": "Cell. Signal.",
"date": "2007",
"authors": "Raaijmakers Judith H, Deneubourg Laurence, Rehmann Holger, de Koning John, Zhang Zhongchun, Krugmann Sonja, Erneux Christophe, Bos Johannes L",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "17314030",
"url": "https://glygen.org/publication/PubMed/17314030"
}
]
},
{
"title": "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2007",
"authors": "Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "17389395",
"url": "https://glygen.org/publication/PubMed/17389395"
}
]
},
{
"title": "Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.",
"journal": "J. Med. Genet.",
"date": "2007",
"authors": "Mar\u00e7ano Ana Carolina Braga, Burke Beverley, Gungadoo Johannie, Wallace Chris, Kaisaki Pamela J, Woon Peng Y, Farrall Martin, Clayton David, Brown Morris, Dominiczak Anna, Connell John M, Webster John, Lathrop Mark, Caulfield Mark, Samani Nilesh, Gauguier Dominique, Munroe Patricia B",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "17557929",
"url": "https://glygen.org/publication/PubMed/17557929"
}
]
},
{
"title": "Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes.",
"journal": "Traffic (Copenhagen, Denmark)",
"date": "2007",
"authors": "Cao C, Laporte J, Backer JM, Wandinger-Ness A, Stein MP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "17651088",
"url": "https://glygen.org/publication/PubMed/17651088"
}
]
},
{
"title": "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.",
"journal": "Cell",
"date": "2007",
"authors": "Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "18083107",
"url": "https://glygen.org/publication/PubMed/18083107"
}
]
},
{
"title": "The dual phosphatase activity of synaptojanin1 is required for both efficient synaptic vesicle endocytosis and reavailability at nerve terminals.",
"journal": "Neuron",
"date": "2007",
"authors": "Mani M, Lee SY, Lucast L, Cremona O, Di Paolo G, De Camilli P, Ryan TA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "18093523",
"url": "https://glygen.org/publication/PubMed/18093523"
}
]
},
{
"title": "Motif-specific sampling of phosphoproteomes.",
"journal": "Journal of proteome research",
"date": "2008",
"authors": "Ruse CI, McClatchy DB, Lu B, Cociorva D, Motoyama A, Park SK, Yates JR 3rd",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "18452278",
"url": "https://glygen.org/publication/PubMed/18452278"
}
]
},
{
"title": "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.",
"journal": "Science (New York, N.Y.)",
"date": "2008",
"authors": "Lin H, Lee E, Hestir K, Leo C, Huang M, Bosch E, Halenbeck R, Wu G, Zhou A, Behrens D, Hollenbaugh D, Linnemann T, Qin M, Wong J, Chu K, Doberstein SK, Williams LT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "18467591",
"url": "https://glygen.org/publication/PubMed/18467591"
}
]
},
{
"title": "A quantitative atlas of mitotic phosphorylation.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2008",
"authors": "Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "18669648",
"url": "https://glygen.org/publication/PubMed/18669648"
}
]
},
{
"title": "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.",
"journal": "Mol. Cell",
"date": "2008",
"authors": "Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "18691976",
"url": "https://glygen.org/publication/PubMed/18691976"
}
]
},
{
"title": "Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron.",
"journal": "American journal of physiology. Renal physiology",
"date": "2008",
"authors": "Clarke JH, Emson PC, Irvine RF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "18753295",
"url": "https://glygen.org/publication/PubMed/18753295"
}
]
},
{
"title": "MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis.",
"journal": "The Journal of biological chemistry",
"date": "2009",
"authors": "Zou J, Chang SC, Marjanovic J, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "19038970",
"url": "https://glygen.org/publication/PubMed/19038970"
}
]
},
{
"title": "Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.",
"journal": "The Journal of biological chemistry",
"date": "2009",
"authors": "Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "19179337",
"url": "https://glygen.org/publication/PubMed/19179337"
}
]
},
{
"title": "Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.",
"journal": "Molecular & cellular proteomics : MCP",
"date": "2009",
"authors": "Pan C, Olsen JV, Daub H, Mann M",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "19651622",
"url": "https://glygen.org/publication/PubMed/19651622"
}
]
},
{
"title": "Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases.",
"journal": "Advances in enzyme regulation",
"date": "2010",
"authors": "Clarke JH, Wang M, Irvine RF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "19896968",
"url": "https://glygen.org/publication/PubMed/19896968"
}
]
},
{
"title": "Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2009",
"authors": "St-Germain JR, Taylor P, Tong J, Jin LL, Nikolic A, Stewart II, Ewing RM, Dharsee M, Li Z, Trudel S, Moran MF",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "19901323",
"url": "https://glygen.org/publication/PubMed/19901323"
}
]
},
{
"title": "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.",
"journal": "Science signaling",
"date": "2010",
"authors": "Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357-1",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357-1"
}
],
"reference": [
{
"type": "PubMed",
"id": "20068231",
"url": "https://glygen.org/publication/PubMed/20068231"
}
]
},
{
"title": "IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation.",
"journal": "Cell death and differentiation",
"date": "2010",
"authors": "Chihara T, Suzu S, Hassan R, Chutiwitoonchai N, Hiyoshi M, Motoyoshi K, Kimura F, Okada S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "20489731",
"url": "https://glygen.org/publication/PubMed/20489731"
}
]
},
{
"title": "FCRL6 receptor: expression and associated proteins.",
"journal": "Immunol. Lett.",
"date": "2011",
"authors": "Kulemzin SV, Zamoshnikova AY, Yurchenko MY, Vitak NY, Najakshin AM, Fayngerts SA, Chikaev NA, Reshetnikova ES, Kashirina NM, Peclo MM, Rutkevich PN, Shevelev AY, Yanushevskaya EV, Baranov KO, Mamonkin M, Vlasik TN, Sidorenko SP, Taranin AV, Mechetina LV",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "20933011",
"url": "https://glygen.org/publication/PubMed/20933011"
}
]
},
{
"title": "Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.",
"journal": "PloS one",
"date": "2010",
"authors": "Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "21049007",
"url": "https://glygen.org/publication/PubMed/21049007"
}
]
},
{
"title": "Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.",
"journal": "The Biochemical journal",
"date": "2011",
"authors": "Wullschleger S, Wasserman DH, Gray A, Sakamoto K, Alessi DR",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "21204784",
"url": "https://glygen.org/publication/PubMed/21204784"
}
]
},
{
"title": "SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.",
"journal": "The Journal of cell biology",
"date": "2011",
"authors": "Hasegawa J, Tokuda E, Tenno T, Tsujita K, Sawai H, Hiroaki H, Takenawa T, Itoh T",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "21624956",
"url": "https://glygen.org/publication/PubMed/21624956"
}
]
},
{
"title": "Evidence of SHIP2 Ser132 phosphorylation, its nuclear localization and stability.",
"journal": "The Biochemical journal",
"date": "2011",
"authors": "Elong Edimo W, Derua R, Janssens V, Nakamura T, Vanderwinden JM, Waelkens E, Erneux C",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "21770892",
"url": "https://glygen.org/publication/PubMed/21770892"
}
]
},
{
"title": "Colony-stimulating factor 1 activates protein kinase C in human monocytes.",
"journal": "The EMBO journal",
"date": "1990",
"authors": "Imamura K, Dianoux A, Nakamura T, Kufe D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "2196173",
"url": "https://glygen.org/publication/PubMed/2196173"
}
]
},
{
"title": "Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain development.",
"journal": "Gene",
"date": "2012",
"authors": "Yamada K, Nomura N, Yamano A, Yamada Y, Wakamatsu N",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "22037487",
"url": "https://glygen.org/publication/PubMed/22037487"
}
]
},
{
"title": "Extracellular complexes of the hematopoietic human and mouse CSF-1 receptor are driven by common assembly principles.",
"journal": "Structure (London, England : 1993)",
"date": "2011",
"authors": "Elegheert J, Desfosses A, Shkumatov AV, Wu X, Bracke N, Verstraete K, Van Craenenbroeck K, Brooks BR, Svergun DI, Vergauwen B, Gutsche I, Savvides SN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "22153499",
"url": "https://glygen.org/publication/PubMed/22153499"
}
]
},
{
"title": "Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.",
"journal": "PloS one",
"date": "2011",
"authors": "Venkatareddy M, Cook L, Abuarquob K, Verma R, Garg P",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "22194892",
"url": "https://glygen.org/publication/PubMed/22194892"
}
]
},
{
"title": "Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R.",
"journal": "Structure (London, England : 1993)",
"date": "2012",
"authors": "Ma X, Lin WY, Chen Y, Stawicki S, Mukhyala K, Wu Y, Martin F, Bazan JF, Starovasnik MA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "22483114",
"url": "https://glygen.org/publication/PubMed/22483114"
}
]
},
{
"title": "Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "2012",
"authors": "Zou J, Zhang C, Marjanovic J, Kisseleva MV, Majerus PW, Wilson MP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "22647598",
"url": "https://glygen.org/publication/PubMed/22647598"
}
]
},
{
"title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.",
"journal": "Journal of proteome research",
"date": "2013",
"authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "23186163",
"url": "https://glygen.org/publication/PubMed/23186163"
}
]
},
{
"title": "Exome sequencing identifies INPPL1 mutations as a cause of opsismodysplasia.",
"journal": "American journal of human genetics",
"date": "2013",
"authors": "Huber C, Faqeih EA, Bartholdi D, Bole-Feysot C, Borochowitz Z, Cavalcanti DP, Frigo A, Nitschke P, Roume J, Santos HG, Shalev SA, Superti-Furga A, Delezoide AL, Le Merrer M, Munnich A, Cormier-Daire V",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "23273569",
"url": "https://glygen.org/publication/PubMed/23273569"
}
]
},
{
"title": "Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.",
"journal": "Journal of proteome research",
"date": "2013",
"authors": "Hahne H, Sobotzki N, Nyberg T, Helm D, Borodkin VS, van Aalten DM, Agnew B, Kuster B",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "O15357",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "23301498",
"url": "https://glygen.org/publication/PubMed/23301498"
}
]
},
{
"title": "RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane Trafficking.",
"journal": "International journal of molecular sciences",
"date": "2013",
"authors": "Kitagishi Y, Matsuda S",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "23519112",
"url": "https://glygen.org/publication/PubMed/23519112"
}
]
},
{
"title": "Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization.",
"journal": "The Biochemical journal",
"date": "2013",
"authors": "Clarke JH, Irvine RF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "23758345",
"url": "https://glygen.org/publication/PubMed/23758345"
}
]
},
{
"title": "Phosphorylated SHIP2 on Y1135 localizes at focal adhesions and at the mitotic spindle in cancer cell lines.",
"journal": "Cellular signalling",
"date": "2014",
"authors": "Deneubourg L, Elong Edimo W, Moreau C, Vanderwinden JM, Erneux C",
"evidence": [
{
"database": "iPTMnet",
"id": "O15357",
"url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "24561238",
"url": "https://glygen.org/publication/PubMed/24561238"
}
]
},
{
"title": "CSF-1 receptor signaling in myeloid cells.",
"journal": "Cold Spring Harbor perspectives in biology",
"date": "2014",
"authors": "Stanley ER, Chitu V",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "24890514",
"url": "https://glygen.org/publication/PubMed/24890514"
}
]
},
{
"title": "The function of phosphatidylinositol 5-phosphate 4-kinase gamma (PI5P4Kgamma) explored using a specific inhibitor that targets the PI5P-binding site.",
"journal": "The Biochemical journal",
"date": "2015",
"authors": "Clarke JH, Giudici ML, Burke JE, Williams RL, Maloney DJ, Marugan J, Irvine RF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "25495341",
"url": "https://glygen.org/publication/PubMed/25495341"
}
]
},
{
"title": "Isolation and characterization of one soluble and two membrane-associated forms of phosphoinositide-specific phospholipase C from human platelets.",
"journal": "Biochemistry",
"date": "1989",
"authors": "Baldassare JJ, Henderson PA, Fisher GJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "2550068",
"url": "https://glygen.org/publication/PubMed/2550068"
}
]
},
{
"title": "The PRKAA1/AMPKalpha1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.",
"journal": "Autophagy",
"date": "2015",
"authors": "Obba S, Hizir Z, Boyer L, Selimoglu-Buet D, Pfeifer A, Michel G, Hamouda MA, Goncalves D, Cerezo M, Marchetti S, Rocchi S, Droin N, Cluzeau T, Robert G, Luciano F, Robaye B, Foretz M, Viollet B, Legros L, Solary E, Auberger P, Jacquel A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "26029847",
"url": "https://glygen.org/publication/PubMed/26029847"
}
]
},
{
"title": "Structure and Assembly Mechanism of the Signaling Complex Mediated by Human CSF-1.",
"journal": "Structure (London, England : 1993)",
"date": "2015",
"authors": "Felix J, De Munck S, Verstraete K, Meuris L, Callewaert N, Elegheert J, Savvides SN",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "26235028",
"url": "https://glygen.org/publication/PubMed/26235028"
}
]
},
{
"title": "Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets.",
"journal": "The Journal of biological chemistry",
"date": "1988",
"authors": "Banno Y, Yada Y, Nozawa Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "2841328",
"url": "https://glygen.org/publication/PubMed/2841328"
}
]
},
{
"title": "Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag).",
"journal": "Molecular & cellular proteomics : MCP",
"date": "2018",
"authors": "Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi CR, Pitteri SJ",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "O15357",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15357"
},
{
"database": "O-GlcNAc Atlas",
"id": "O15357",
"url": "https://oglcnac.org/atlas/detail/O15357"
},
{
"database": "GlyGen",
"id": "GLY_000142",
"url": "https://data.glygen.org/GLY_000142"
}
],
"reference": [
{
"type": "PubMed",
"id": "29351928",
"url": "https://glygen.org/publication/PubMed/29351928"
}
]
},
{
"title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.",
"journal": "Chemical communications (Cambridge, England)",
"date": "2018",
"authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "O15357",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "30379171",
"url": "https://glygen.org/publication/PubMed/30379171"
}
]
},
{
"title": "A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.",
"journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
"date": "2021",
"authors": "Le Coq J, Lopez Navajas P, Rodrigo Martin B, Alfonso C, Lietha D",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
}
],
"reference": [
{
"type": "PubMed",
"id": "34314064",
"url": "https://glygen.org/publication/PubMed/34314064"
}
]
},
{
"title": "Simultaneously Identifying and Distinguishing Glycoproteins with O-GlcNAc and O-GalNAc (the Tn Antigen) in Human Cancer Cells.",
"journal": "Analytical chemistry",
"date": "2022",
"authors": "Xu S, Zheng J, Xiao H, Wu R",
"evidence": [
{
"database": "O-GlcNAc Database",
"id": "O15357",
"url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "35132862",
"url": "https://glygen.org/publication/PubMed/35132862"
}
]
},
{
"title": "OxLDL-stimulated macrophage exosomes promote proatherogenic vascular smooth muscle cell viability and invasion via delivering miR-186-5p then inactivating SHIP2 mediated PI3K/AKT/mTOR pathway.",
"journal": "Molecular immunology",
"date": "2022",
"authors": "Ren L, Chen S, Yao D, Yan H",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
}
],
"reference": [
{
"type": "PubMed",
"id": "35421738",
"url": "https://glygen.org/publication/PubMed/35421738"
}
]
},
{
"title": "PHB2 promotes SHIP2 ubiquitination via the E3 ligase NEDD4 to regulate AKT signaling in gastric cancer.",
"journal": "Journal of experimental & clinical cancer research : CR",
"date": "2024-01-11",
"authors": "Xu Liang, Xiang Wanying, Yang Jiezhen, Gao Jing, Wang Xinyue, Meng Li, Ye Kaihong, Zhao Xiao Hong, Zhang Xu Dong, Jin Lei, Ye Yan",
"evidence": [
{
"database": "RefSeq",
"id": "NP_001558",
"url": "https://www.ncbi.nlm.nih.gov/protein/NP_001558"
}
],
"reference": [
{
"type": "PubMed",
"id": "38200519",
"url": "https://glygen.org/publication/PubMed/38200519"
}
]
},
{
"title": "Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAK and dynamin.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1995",
"authors": "Kharbanda S, Saleem A, Yuan Z, Emoto Y, Prasad KV, Kufe D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "7597091",
"url": "https://glygen.org/publication/PubMed/7597091"
}
]
},
{
"title": "The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Norris FA, Auethavekiat V, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "7608176",
"url": "https://glygen.org/publication/PubMed/7608176"
}
]
},
{
"title": "Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.",
"journal": "Science (New York, N.Y.)",
"date": "1995",
"authors": "Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nurnberg B, et al.",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "7624799",
"url": "https://glygen.org/publication/PubMed/7624799"
}
]
},
{
"title": "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.",
"journal": "The EMBO journal",
"date": "1993",
"authors": "Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "7681396",
"url": "https://glygen.org/publication/PubMed/7681396"
}
]
},
{
"title": "Properties of type II inositol polyphosphate 5-phosphatase.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Jefferson AB, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "7721860",
"url": "https://glygen.org/publication/PubMed/7721860"
}
]
},
{
"title": "Monocyte colony-stimulating factor stimulates binding of phosphatidylinositol 3-kinase to Grb2.Sos complexes in human monocytes.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Saleem A, Kharbanda S, Yuan ZM, Kufe D",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "7737969",
"url": "https://glygen.org/publication/PubMed/7737969"
}
]
},
{
"title": "The protein deficient in Lowe syndrome is a phosphatidylinositol-4,5-bisphosphate 5-phosphatase.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1995",
"authors": "Zhang X, Jefferson AB, Auethavekiat V, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "7761412",
"url": "https://glygen.org/publication/PubMed/7761412"
}
]
},
{
"title": "Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis.",
"journal": "The Journal of biological chemistry",
"date": "1995",
"authors": "Cheng HF, Jiang MJ, Chen CL, Liu SM, Wong LP, Lomasney JW, King K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "7890667",
"url": "https://glygen.org/publication/PubMed/7890667"
}
]
},
{
"title": "Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins.",
"journal": "Oncogene",
"date": "1994",
"authors": "Salcini AE, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci PG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "8084588",
"url": "https://glygen.org/publication/PubMed/8084588"
}
]
},
{
"title": "The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation.",
"journal": "The Journal of biological chemistry",
"date": "1994",
"authors": "Ravichandran KS, Burakoff SJ",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "8294403",
"url": "https://glygen.org/publication/PubMed/8294403"
}
]
},
{
"title": "Identification of the ligand-binding regions in the macrophage colony-stimulating factor receptor extracellular domain.",
"journal": "Molecular and cellular biology",
"date": "1993",
"authors": "Wang ZE, Myles GM, Brandt CS, Lioubin MN, Rohrschneider L",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "8355686",
"url": "https://glygen.org/publication/PubMed/8355686"
}
]
},
{
"title": "Purification, molecular cloning, and sequencing of phospholipase C-beta 4.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Lee CW, Park DJ, Lee KH, Kim CG, Rhee SG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8407970",
"url": "https://glygen.org/publication/PubMed/8407970"
}
]
},
{
"title": "Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3.",
"journal": "The Journal of biological chemistry",
"date": "1993",
"authors": "Jhon DY, Lee HH, Park D, Lee CW, Lee KH, Yoo OJ, Rhee SG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8454637",
"url": "https://glygen.org/publication/PubMed/8454637"
}
]
},
{
"title": "Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases.",
"journal": "Genomics",
"date": "1995",
"authors": "Hejna J A, Saito H, Merkens L S, Tittle T V, Jakobs P M, Whitney M A, Grompe M, Friedberg A S, Moses R E",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "8530088",
"url": "https://glygen.org/publication/PubMed/8530088"
}
]
},
{
"title": "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4).",
"journal": "Genomics",
"date": "1995",
"authors": "Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8530101",
"url": "https://glygen.org/publication/PubMed/8530101"
}
]
},
{
"title": "Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme.",
"journal": "The Journal of biological chemistry",
"date": "1996",
"authors": "Wilson MP, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "8662638",
"url": "https://glygen.org/publication/PubMed/8662638"
}
]
},
{
"title": "Purification and characterization of the phosphatidylinositol-3,4,5-trisphosphate phosphatase in bovine thymus.",
"journal": "European journal of biochemistry",
"date": "1996",
"authors": "Kabuyama Y, Nakatsu N, Homma Y, Fukui Y",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "8681945",
"url": "https://glygen.org/publication/PubMed/8681945"
}
]
},
{
"title": "Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.",
"journal": "Current biology : CB",
"date": "1996",
"authors": "Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "8723348",
"url": "https://glygen.org/publication/PubMed/8723348"
}
]
},
{
"title": "Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.",
"journal": "Biochemical and biophysical research communications",
"date": "1996",
"authors": "Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "8769125",
"url": "https://glygen.org/publication/PubMed/8769125"
}
]
},
{
"title": "Growth and differentiation signals regulated by the M-CSF receptor.",
"journal": "Molecular reproduction and development",
"date": "1997",
"authors": "Rohrschneider LR, Bourette RP, Lioubin MN, Algate PA, Myles GM, Carlberg K",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "8981370",
"url": "https://glygen.org/publication/PubMed/8981370"
}
]
},
{
"title": "The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101.",
"journal": "Cell",
"date": "1997",
"authors": "Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J, Smrcka AS, Thelen M, Cadwallader K, Tempst P, Hawkins PT",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9094719",
"url": "https://glygen.org/publication/PubMed/9094719"
}
]
},
{
"title": "Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Lamkin TD, Walk SF, Liu L, Damen JE, Krystal G, Ravichandran KS",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "9099679",
"url": "https://glygen.org/publication/PubMed/9099679"
}
]
},
{
"title": "Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.",
"journal": "Blood",
"date": "1997",
"authors": "Odai H, Sasaki K, Iwamatsu A, Nakamoto T, Ueno H, Yamagata T, Mitani K, Yazaki Y, Hirai H",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "9108392",
"url": "https://glygen.org/publication/PubMed/9108392"
}
]
},
{
"title": "P110delta, a novel phosphoinositide 3-kinase in leukocytes.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1997",
"authors": "Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9113989",
"url": "https://glygen.org/publication/PubMed/9113989"
}
]
},
{
"title": "Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Zhang X, Loijens JC, Boronenkov IV, Parker GJ, Norris FA, Chen J, Thum O, Prestwich GD, Majerus PW, Anderson RA",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9211928",
"url": "https://glygen.org/publication/PubMed/9211928"
}
]
},
{
"title": "Bryostatin 1 (bryo1)-induced monocytic differentiation in THP-1 human leukemia cells is associated with enhanced c-fyn tyrosine kinase and M-CSF receptors.",
"journal": "Leukemia research",
"date": "1997",
"authors": "Li Y, Mohammad RM, al-Katib A, Varterasian ML, Chen B",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-9680350",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350"
}
],
"reference": [
{
"type": "PubMed",
"id": "9225065",
"url": "https://glygen.org/publication/PubMed/9225065"
}
]
},
{
"title": "Phosphatidylinositol 3-kinase in bovine photoreceptor rod outer segments.",
"journal": "Investigative ophthalmology & visual science",
"date": "1997",
"authors": "Guo X, Ghalayini AJ, Chen H, Anderson RE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9286278",
"url": "https://glygen.org/publication/PubMed/9286278"
}
]
},
{
"title": "The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.",
"journal": "The Journal of biological chemistry",
"date": "1997",
"authors": "Norris FA, Atkins RC, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9295334",
"url": "https://glygen.org/publication/PubMed/9295334"
}
]
},
{
"title": "Expression, purification and kinetic properties of human recombinant phospholipase C delta 3.",
"journal": "Acta biochimica Polonica",
"date": "1997",
"authors": "Pawelczyk T, Matecki A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "9360711",
"url": "https://glygen.org/publication/PubMed/9360711"
}
]
},
{
"title": "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.",
"journal": "Nature",
"date": "1997",
"authors": "Rameh LE, Tolias KF, Duckworth BC, Cantley LC",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9367159",
"url": "https://glygen.org/publication/PubMed/9367159"
}
]
},
{
"title": "Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP.",
"journal": "Biochem. Biophys. Res. Commun.",
"date": "1997",
"authors": "Pesesse X, Deleu S, De Smedt F, Drayer L, Erneux C",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"reference": [
{
"type": "PubMed",
"id": "9367831",
"url": "https://glygen.org/publication/PubMed/9367831"
}
]
},
{
"title": "Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15.",
"journal": "FEBS letters",
"date": "1997",
"authors": "Haffner C, Takei K, Chen H, Ringstad N, Hudson A, Butler MH, Salcini AE, Di Fiore PP, De Camilli P",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9428629",
"url": "https://glygen.org/publication/PubMed/9428629"
}
]
},
{
"title": "Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Zhang X, Hartz PA, Philip E, Racusen LC, Majerus PW",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1855204",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204"
}
],
"reference": [
{
"type": "PubMed",
"id": "9430698",
"url": "https://glygen.org/publication/PubMed/9430698"
}
]
},
{
"title": "Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain.",
"journal": "Biochemical and biophysical research communications",
"date": "1998",
"authors": "Misawa H, Ohtsubo M, Copeland NG, Gilbert DJ, Jenkins NA, Yoshimura A",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9514948",
"url": "https://glygen.org/publication/PubMed/9514948"
}
]
},
{
"title": "A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Ono F, Nakagawa T, Saito S, Owada Y, Sakagami H, Goto K, Suzuki M, Matsuno S, Kondo H",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9516481",
"url": "https://glygen.org/publication/PubMed/9516481"
}
]
},
{
"title": "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.",
"journal": "Gene",
"date": "1998",
"authors": "Dey BR, Furlanetto RW, Nissley SP",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9524259",
"url": "https://glygen.org/publication/PubMed/9524259"
}
]
},
{
"title": "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Maehama T, Dixon JE",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9593664",
"url": "https://glygen.org/publication/PubMed/9593664"
}
]
},
{
"title": "Type I phosphatidylinositol-4-phosphate 5-kinases synthesize the novel lipids phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 5-phosphate.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Chen J, Prestwich GD, Cantley LC, Carpenter CL",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9660759",
"url": "https://glygen.org/publication/PubMed/9660759"
}
]
},
{
"title": "Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Habib T, Hejna JA, Moses RE, Decker SJ",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9660833",
"url": "https://glygen.org/publication/PubMed/9660833"
}
]
},
{
"title": "The lipid phosphatase activity of PTEN is critical for its tumor supressor function.",
"journal": "Proceedings of the National Academy of Sciences of the United States of America",
"date": "1998",
"authors": "Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9811831",
"url": "https://glygen.org/publication/PubMed/9811831"
}
]
},
{
"title": "Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity.",
"journal": "The Journal of biological chemistry",
"date": "1998",
"authors": "Arcaro A, Volinia S, Zvelebil MJ, Stein R, Watton SJ, Layton MJ, Gout I, Ahmadi K, Downward J, Waterfield MD",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-1660499",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499"
}
],
"reference": [
{
"type": "PubMed",
"id": "9830063",
"url": "https://glygen.org/publication/PubMed/9830063"
}
]
},
{
"title": "Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation.",
"journal": "Molecular cell",
"date": "1998",
"authors": "Gu H, Pratt JC, Burakoff SJ, Neel BG",
"evidence": [
{
"database": "Reactome",
"id": "R-HSA-912526",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526"
}
],
"reference": [
{
"type": "PubMed",
"id": "9885561",
"url": "https://glygen.org/publication/PubMed/9885561"
}
]
}
],
"pathway": [
{
"id": "hsa:3636",
"name": "",
"url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3636",
"resource": "KEGG Pathway"
},
{
"id": "R-HSA-1660499",
"name": "Synthesis of PIPs at the plasma membrane",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1660499",
"resource": "Reactome",
"description": "Synthesis of PIPs at the plasma membrane"
},
{
"id": "R-HSA-1855204",
"name": "Synthesis of IP3 and IP4 in the cytosol",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855204",
"resource": "Reactome",
"description": "Synthesis of IP3 and IP4 in the cytosol"
},
{
"id": "R-HSA-912526",
"name": "Interleukin receptor SHC signaling",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-912526",
"resource": "Reactome",
"description": "Interleukin receptor SHC signaling"
},
{
"id": "R-HSA-9680350",
"name": "Signaling by CSF1 (M-CSF) in myeloid cells",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680350",
"resource": "Reactome",
"description": "Signaling by CSF1 (M-CSF) in myeloid cells"
}
],
"orthologs": [
{
"uniprot_canonical_ac": "Q6P549-1",
"protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2",
"gene_name": "Inppl1",
"tax_id": 10090,
"organism": "Mus musculus",
"sequence": {
"sequence": "MASVCGTPSPGGALGSPAPAWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPDDRDASDVEDEKPPLPPRSGSTSISAPVGPSSPLPTPETPTTPAAESTPNGLSTVSHEYLKGSYGLDLEAVRGGASNLPHLTRTLVTSCRRLHSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQSLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPLQPSIRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNRHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKALDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTTRRNQNYLDILRLLSLGDRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRREFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDDTGAKSKVPSVSRGSQEHRSGSRKPASTETSCPLSKLFEEPEKPPPTGRPPAPPRAVPREEPLNPRLKSEGTSEQEGVAAPPPKNSFNNPAYYVLEGVPHQLLPLEPPSLARAPLPPATKNKVAITVPAPQLGRHRTPRVGEGSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSGGEARGPPPPKAHPRPPLPPGTSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPGPGRSALLPNPLELQPPRGPSDYGRPLSFPPPRIRESIQEDLAEEAPCPQGGRASGLGEAGMGAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK",
"length": 1257
},
"evidence": [
{
"id": "45930384",
"url": "http://www.informatics.jax.org/homology/45930384",
"database": "MGI"
},
{
"id": "O15357",
"url": "https://omabrowser.org/oma/group/O15357/",
"database": "OMA"
}
],
"common_name": "Mouse"
},
{
"uniprot_canonical_ac": "Q9WVR3-1",
"protein_name": "Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2",
"gene_name": "Inppl1",
"tax_id": 10116,
"organism": "Rattus norvegicus",
"sequence": {
"sequence": "MASVCGAPSPGGALGSQAPAWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPDDRDASDVEDEKPPLPPRSGSTSISVPAGPSSPLPAPETPTTPAAESTPNGLSTVSHEYLKGSYGLDLEAVRGGASNLPHLTRTLVTSCRRLHSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQSLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPLQPSIRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKALDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTTRRNQNYLDILRLLSLGDRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRREFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDDTGAKSKAPSVLRGSQEHRSGSRKPTSTEASCPLSKLFEEPEKPPPTGRPPAPPRAVPREESLNPRLKSEGTPEQEGVAAPPPKNSFNNPAYYVLEGVPHQLLPLEPTSFARAPIPPTTKNKVAITVPAPQLGRHRTPRVGEGSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSVGEARGPPPPKAHPRPPLPPGTSPASTFLEEVASADDRSCSVLQMAKTLSEVDYSPGPGRSALLPNPLELQLPRGPSDYGRPLSFPPPRIRESIQEDLAEEAPCPQGGRASGLGEAGMGAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK",
"length": 1257
},
"evidence": [
{
"id": "45930384",
"url": "http://www.informatics.jax.org/homology/45930384",
"database": "MGI"
}
],
"common_name": "Rat"
}
],
"go_annotation": {
"categories": [
{
"name": "Cellular Component",
"total": 8,
"go_terms": [
{
"name": "spindle pole",
"id": "GO:0000922",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "nucleus",
"id": "GO:0005634",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "Golgi apparatus",
"id": "GO:0005794",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "cytosol",
"id": "GO:0005829",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "nuclear speck",
"id": "GO:0016607",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "lamellipodium",
"id": "GO:0030027",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030027",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "filopodium",
"id": "GO:0030175",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030175",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "basal plasma membrane",
"id": "GO:0009925",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009925",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
}
]
},
{
"name": "Molecular Function",
"total": 5,
"go_terms": [
{
"name": "actin binding",
"id": "GO:0003779",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "SH3 domain binding",
"id": "GO:0017124",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "SH2 domain binding",
"id": "GO:0042169",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042169",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "inositol-polyphosphate 5-phosphatase activity",
"id": "GO:0004445",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004445",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity",
"id": "GO:0034485",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034485",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
}
]
},
{
"name": "Biological Process",
"total": 18,
"go_terms": [
{
"name": "endocytosis",
"id": "GO:0006897",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006897",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "actin filament organization",
"id": "GO:0007015",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007015",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "cell adhesion",
"id": "GO:0007155",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "negative regulation of cell population proliferation",
"id": "GO:0008285",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "negative regulation of gene expression",
"id": "GO:0010629",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010629",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "regulation of immune response",
"id": "GO:0050776",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050776",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "regulation of protein localization",
"id": "GO:0032880",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032880",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "glucose metabolic process",
"id": "GO:0006006",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006006",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "post-embryonic development",
"id": "GO:0009791",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009791",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "response to insulin",
"id": "GO:0032868",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032868",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "phosphatidylinositol biosynthetic process",
"id": "GO:0006661",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006661",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "ruffle assembly",
"id": "GO:0097178",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097178",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "establishment of mitotic spindle orientation",
"id": "GO:0000132",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000132",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "phosphatidylinositol dephosphorylation",
"id": "GO:0046856",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046856",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "immune system process",
"id": "GO:0002376",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002376",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "endochondral ossification",
"id": "GO:0001958",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001958",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "negative regulation of insulin-like growth factor receptor signaling pathway",
"id": "GO:0043569",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043569",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
},
{
"name": "regulation of actin filament organization",
"id": "GO:0110053",
"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0110053",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
}
],
"pmid": ""
}
]
}
]
},
"pro_annotation": [],
"site_annotation": [
{
"start_pos": 441,
"end_pos": 443,
"annotation": "n_glycosylation_sequon"
},
{
"start_pos": 551,
"end_pos": 553,
"annotation": "n_glycosylation_sequon"
}
],
"ptm_annotation": [
{
"annotation": "Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli such as insulin, growth factors such as EGF or PDGF, chemokines, integrin ligands and hypertonic and oxidative stress. May be phosphorylated upon IgG receptor FCGR2B-binding. Phosphorylated at Tyr-986 following cell attachment and spreading. Phosphorylated at Tyr-1162 following EGF signaling pathway stimulation. Phosphorylated at Thr-958 in response to PDGF.",
"evidence": [
{
"database": "UniProtKB",
"id": "O15357",
"url": "https://www.uniprot.org/uniprot/O15357"
},
{
"database": "PubMed",
"id": "9660833",
"url": "https://glygen.org/publication/PubMed/9660833"
},
{
"database": "PubMed",
"id": "12235291",
"url": "https://glygen.org/publication/PubMed/12235291"
},
{
"database": "PubMed",
"id": "10194451",
"url": "https://glygen.org/publication/PubMed/10194451"
},
{
"database": "PubMed",
"id": "17219406",
"url": "https://glygen.org/publication/PubMed/17219406"
},
{
"database": "PubMed",
"id": "11158326",
"url": "https://glygen.org/publication/PubMed/11158326"
},
{
"database": "PubMed",
"id": "11687594",
"url": "https://glygen.org/publication/PubMed/11687594"
},
{
"database": "PubMed",
"id": "12690104",
"url": "https://glygen.org/publication/PubMed/12690104"
},
{
"database": "PubMed",
"id": "11349134",
"url": "https://glygen.org/publication/PubMed/11349134"
}
]
}
],
"interactions": [],
"reactions": [
{
"id": "25528",
"name": "",
"equation": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"D3ZGS3-1",
"P97573-1",
"Q9WVR1-1",
"Q9WVR3-1",
"Q9BT40-1",
"Q9NRR6-1",
"Q01968-1",
"O15357-1",
"Q92835-1",
"Q92562-1",
"Q8C5L6-1",
"Q9JII1-1",
"Q6NVF0-1",
"Q9ES52-1",
"Q6P549-1",
"Q91WF7-1"
],
"evidence": [
{
"id": "25528",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/25528"
}
]
},
{
"id": "43548",
"name": "",
"equation": "1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9WVR3-1",
"Q9BT40-1",
"O15357-1",
"Q8C5L6-1",
"Q6P549-1"
],
"evidence": [
{
"id": "43548",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/43548"
}
]
},
{
"id": "43556",
"name": "",
"equation": "1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate",
"summary": "",
"cellular_location": "",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q9WVR3-1",
"O15357-1",
"Q6P549-1"
],
"evidence": [
{
"id": "43556",
"database": "Rhea",
"url": "https://www.rhea-db.org/rhea/43556"
}
]
},
{
"id": "R-HSA-1675949",
"name": "PI(3,4,5)P3 is dephosphorylated to PI(3,4)P2 by INPP5[2] at the plasma membrane",
"equation": "",
"summary": "At the plasma membrane, phosphatidylinositol 5-phosphatases dephosphorylate phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) to phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2). The phosphatidylinositol 5-phosphatases involved are: inositol polyphosphate 5-phosphatase K (INPP5K) aka SKIP (Ijuin et al. 2000, Gurung et al. 2003), phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP (Gurung et al. 2003, Mochizuki & Takenawa 1999), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1 (Drayer et al. 1995, Kavanaugh et al. 1996, Dunant et al. 2000), and phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2 (Habib et al. 1998, Wisniewski et al. 1999, Pesesse et al. 2001).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [
"R-ALL-179838"
],
"output_participant_list": [],
"enzyme_list": [
"O15357-1",
"Q9BT40-1",
"Q15735-1",
"Q92835-1"
],
"evidence": [
{
"id": "R-HSA-1675949",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1675949"
}
]
},
{
"id": "R-HSA-1855218",
"name": "I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol",
"equation": "",
"summary": "A group of inositol phosphatases and the broad specificity enzyme inositol-tetrakisphosphate 1-kinase (ITPK1) dephosphorylate inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,3,4-trisphosphate (I(1,3,4)P3). The group of inositol phosphatases involved are: inositol polyphosphate 5-phosphatase OCRL-1 (OCRL), phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (INPP5D) aka SHIP1, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 (INPPL1) aka SHIP2, phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) aka PIPP, and synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1).
The following lists the above proteins with their corresponding literature references: OCRL (Chang et al. 2002, Zhang et al. 1995, Zhang et al. 1998, Schmid et al. 2004); INPP5D (Drayer et al. 1996, Kavanaugh et al. 1996); INPPL1 (Chi et al. 2004); INPP5J (Mochizuki & Thompson 1999); SYNJ1 (Schmid et al. 2004); ITPK1 (Ho et al. 2002).",
"cellular_location": "cytosol",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"Q13572-1",
"O15357-1",
"Q01968-1",
"Q15735-1",
"Q92835-1",
"O43426-1"
],
"evidence": [
{
"id": "R-HSA-1855218",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-1855218"
}
]
},
{
"id": "R-HSA-913374",
"name": "Phosphorylated SHC1 recruits SHIP",
"equation": "",
"summary": "SHIP dephosphorylates PIP3 and may limit the magnitude or duration of signaling events that are dependent upon PIP3-mediated membrane recruitment of plextrin homology (PH) domain signalling proteins such as PI3K and Akt (Aman et al. 1998). The PTB domain of SHC1 binds to phosphorylated tyrosine residues on SHIP. Mutations that inactivate the PTB domain prevent this binding and substitution of F for Y917 and Y1020 on SHIP prevents creation of the phosphotyrosine motifs that are recognized by the SHC1 PTB domain, blocking the interaction (Lamkin et al. 1997). A functional SHIP SH2 domain is also reported as a requirement for association of SHIP with Shc (Liu et al. 1997). GRB2 stabilizes the SHC1/SHIP complex (Harmer & DeFranco 1999), presumably by simultaneously binding via its SH3 domains to SHIP and via its SH2 domain to phosphotyrosines on SHC1, forming a ternary complex of SHC1:GRB2:SHIP described as inducible by IL-3, IL-5 or GM-CSF by many authors (Jucker et al. 1997, Lafrancone et al. 1995, Odai et al. 1997). SHIP2 also associates with SHC1 but does not appear to require Grb2 for stability (Wisniewskiet al. 1999).",
"cellular_location": "cytosol, plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P52333-1",
"O60674-1",
"O15357-1",
"Q92835-1",
"P23458-1"
],
"evidence": [
{
"id": "R-HSA-913374",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-913374"
}
]
},
{
"id": "R-HSA-9680348",
"name": "PIK3R1:PIK3CA,B,G (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated",
"equation": "",
"summary": "The PIK3R1 (p85alpha) subunit of phosphatidylinositol 3-kinase (PI3K) is phosphorylated and binds CBL and CSF1R (inferred from mouse homologs). CBL also directly binds phosphorylated CSF1R (inferred from mouse homologs). GRB2:SOS1 transiently interacts with CSF1R (inferred from mouse homologs) and PI3K (Saleem et al. 1995) in response to CSF1. SHC1 (SHC) interacts with CBL and CSF1R (inferred from mouse homologs). CBL is constitutively bound to GRB2, CBL is phosphorylated, and phosphorylated CBL binds phosphorylated SHC (inferred from mouse homologs). PLCG2 (PLC-gamma2), expressed in the myeloid lineage, binds phosphorylated tyrosine-723 of CSF1R and PLCG2 is phosphorylated in a process that requires the activity of PI3K (inferred from mouse homologs). GRAP2 (MONA) binds phosphorylated tyrosine-699 of CSF1R. GRB2 also interacts with CSF1R (Kharbanda et al. 1995) via phosphotyrosine-699 ( inferred from mouse homologs). GRAP2 binds GAB3, which is then phosphorylated (inferred from mouse homologs). In response to CSF1, the scaffolding protein GAB2 associates with INPP5D (SHIP1) and other proteins involved in CSF1 signaling and GAB2 is phosphorylated directly or indirectly by CSF1R (inferred from mouse homologs). INPPD5D also interacts with the kinase LYN (Baran et al. 2003). INPPL1 (SHIP2), a homolog of INPPD5, binds CSF1R in response to CSF1 (inferred from mouse homologs). GAB3, a homolog of GAB2, associates with CSF1R, is phosphorylated, and interacts with PI3K and PTPN11 (SHP2) (inferred from mouse homologs). The SRC family kinases SRC, FYN, and YES1 (YES) bind phosphorylated CSF1R (Courtneidge et al. 1993, Li et al. 1997, also inferred from mouse homologs). STAT proteins STAT1 and STAT3 bind CSF1R and are phosphorylated (inferred from mouse homologs). STAT5 also appears to be phosphorylated in response to CSF1 (Knowlton et al. 2010). THOC5 (FMIP) binds CSF1R and is phosphorylated (inferred from mouse homologs). The order of binding and phosphorylation of the interactors of CSF1R is unknown. Different subpopulations of CSF1R may be bound to different sets of interactors (inferred from mouse homologs).",
"cellular_location": "plasma membrane",
"input_participant_list": [
"R-HSA-197940",
"R-HSA-202367",
"R-HSA-354251",
"R-HSA-200917",
"R-HSA-9628701",
"R-HSA-373640",
"R-HSA-913354",
"R-HSA-9682751"
],
"output_participant_list": [],
"enzyme_list": [
"P07333-1",
"P42336-1",
"P48736-1",
"P06241-1",
"P12931-1",
"P22681-1",
"O15357-1",
"P07947-1",
"P07948-1",
"P16885-1",
"Q06124-2",
"P08631-1",
"P42338-1",
"Q92835-1"
],
"evidence": [
{
"id": "R-HSA-9680348",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680348"
}
]
},
{
"id": "R-HSA-9680388",
"name": "CSF1R-associated PLCG2 hydrolyzes phosphatidylcholine",
"equation": "",
"summary": "In response to CSF1, PLCG2 (phospholipase C gamma2) associates with CSF1R, is activated by phosphorylation, and hydrolyzes phosphatidylcholine to yield choline phosphate (ChoP, phosphocholine) and 1,2-diacylglycerol (Imamura et al. 1990, Nakamura et al. 1992, Obba et al. 2015, also inferred from mouse homologs). PLCG2 activates pathways that enhance differentiation of macrophages (inferred from mouse homologs).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P07333-1",
"P42336-1",
"P48736-1",
"P06241-1",
"P12931-1",
"P22681-1",
"O15357-1",
"P07947-1",
"P07948-1",
"P16885-1",
"Q06124-2",
"P08631-1",
"P42338-1",
"Q92835-1"
],
"evidence": [
{
"id": "R-HSA-9680388",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680388"
}
]
},
{
"id": "R-HSA-9680389",
"name": "CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2",
"equation": "",
"summary": "Phosphatidylinositol 3-kinase (PI3K) associated with the activated receptor for CSF1, CSF1R (M-CSFR), phosphorylates phosphatidylinositol 4,5-bisphosphate (PIP2) to yield phosphatidylinositol 3,4,5-trisphosphate (PIP3) (Saleem et al. 1995, also inferred from mouse homologs). The regulatory subunit of PI3K, PIK3R1 (p85alpha), binds phosphotyrosine-723 (721 in the mouse homologs) of CSF1R (inferred from mouse homologs). PI3K is important for proliferation, migration, and anti-inflammatory activity of macrophages (inferred from mouse homologs).",
"cellular_location": "plasma membrane",
"input_participant_list": [],
"output_participant_list": [],
"enzyme_list": [
"P07333-1",
"P42336-1",
"P48736-1",
"P06241-1",
"P12931-1",
"P22681-1",
"O15357-1",
"P07947-1",
"P07948-1",
"P16885-1",
"Q06124-2",
"P08631-1",
"P42338-1",
"Q92835-1"
],
"evidence": [
{
"id": "R-HSA-9680389",
"database": "Reactome",
"url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9680389"
}
]
}
],
"reaction_participants": [
{
"participant_id": "R-ALL-179838",
"participant_name": "PI(3,4,5)P3 [plasma membrane]",
"crossref": [
{
"id": "C05981",
"database": "COMPOUND",
"url": ""
},
{
"id": "57836",
"database": "ChEBI",
"url": ""
},
{
"id": "C05981",
"database": "COMPOUND",
"url": ""
},
{
"id": "57836",
"database": "ChEBI",
"url": ""
},
{
"id": "C05981",
"database": "COMPOUND",
"url": ""
},
{
"id": "57836",
"database": "ChEBI",
"url": ""
},
{
"id": "C05981",
"database": "COMPOUND",
"url": ""
},
{
"id": "57836",
"database": "ChEBI",
"url": ""
},
{
"id": "C05981",
"database": "COMPOUND",
"url": ""
},
{
"id": "57836",
"database": "ChEBI",
"url": ""
},
{
"id": "C05981",
"database": "COMPOUND",
"url": ""
},
{
"id": "57836",
"database": "ChEBI",
"url": ""
},
{
"id": "C05981",
"database": "COMPOUND",
"url": ""
},
{
"id": "57836",
"database": "ChEBI",
"url": ""
}
]
},
{
"participant_id": "R-HSA-197940",
"participant_name": "INPP5D [cytosol]",
"crossref": [
{
"id": "Q92835",
"database": "UniProt",
"url": ""
},
{
"id": "6IBD",
"database": "PDB",
"url": ""
},
{
"id": "NP_005532.2",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001017915.1",
"database": "RefSeq",
"url": ""
},
{
"id": "5RXI",
"database": "PDB",
"url": ""
},
{
"id": "5RWF",
"database": "PDB",
"url": ""
},
{
"id": "5RYL",
"database": "PDB",
"url": ""
},
{
"id": "5RYK",
"database": "PDB",
"url": ""
},
{
"id": "5RXJ",
"database": "PDB",
"url": ""
},
{
"id": "5RXH",
"database": "PDB",
"url": ""
},
{
"id": "5RWE",
"database": "PDB",
"url": ""
},
{
"id": "5RXM",
"database": "PDB",
"url": ""
},
{
"id": "5RXO",
"database": "PDB",
"url": ""
},
{
"id": "8PDG",
"database": "PDB",
"url": ""
},
{
"id": "Q92835",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "6XY7",
"database": "PDB",
"url": ""
},
{
"id": "5RWG",
"database": "PDB",
"url": ""
},
{
"id": "5RXK",
"database": "PDB",
"url": ""
},
{
"id": "5RWH",
"database": "PDB",
"url": ""
},
{
"id": "5RXL",
"database": "PDB",
"url": ""
},
{
"id": "5RXQ",
"database": "PDB",
"url": ""
},
{
"id": "5RWK",
"database": "PDB",
"url": ""
},
{
"id": "5RXP",
"database": "PDB",
"url": ""
},
{
"id": "8PDH",
"database": "PDB",
"url": ""
},
{
"id": "8PDJ",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000168918-INPP5D",
"database": "HPA",
"url": ""
},
{
"id": "5RWI",
"database": "PDB",
"url": ""
},
{
"id": "5RWJ",
"database": "PDB",
"url": ""
},
{
"id": "5RWM",
"database": "PDB",
"url": ""
},
{
"id": "5RXR",
"database": "PDB",
"url": ""
},
{
"id": "5RXS",
"database": "PDB",
"url": ""
},
{
"id": "5RWL",
"database": "PDB",
"url": ""
},
{
"id": "5RX8",
"database": "PDB",
"url": ""
},
{
"id": "5RYB",
"database": "PDB",
"url": ""
},
{
"id": "5RYC",
"database": "PDB",
"url": ""
},
{
"id": "5RW5",
"database": "PDB",
"url": ""
},
{
"id": "5RW6",
"database": "PDB",
"url": ""
},
{
"id": "5RX7",
"database": "PDB",
"url": ""
},
{
"id": "5RXA",
"database": "PDB",
"url": ""
},
{
"id": "5RXC",
"database": "PDB",
"url": ""
},
{
"id": "5RXB",
"database": "PDB",
"url": ""
},
{
"id": "5RYE",
"database": "PDB",
"url": ""
},
{
"id": "5RW7",
"database": "PDB",
"url": ""
},
{
"id": "Q92835",
"database": "PRO",
"url": ""
},
{
"id": "5RYD",
"database": "PDB",
"url": ""
},
{
"id": "5RW8",
"database": "PDB",
"url": ""
},
{
"id": "5RX9",
"database": "PDB",
"url": ""
},
{
"id": "5RXE",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000168918",
"database": "OpenTargets",
"url": ""
},
{
"id": "5RYH",
"database": "PDB",
"url": ""
},
{
"id": "5RXD",
"database": "PDB",
"url": ""
},
{
"id": "5RYF",
"database": "PDB",
"url": ""
},
{
"id": "5RWA",
"database": "PDB",
"url": ""
},
{
"id": "5RW9",
"database": "PDB",
"url": ""
},
{
"id": "5RWB",
"database": "PDB",
"url": ""
},
{
"id": "5RYG",
"database": "PDB",
"url": ""
},
{
"id": "5RYJ",
"database": "PDB",
"url": ""
},
{
"id": "5RXG",
"database": "PDB",
"url": ""
},
{
"id": "5RWD",
"database": "PDB",
"url": ""
},
{
"id": "5RYI",
"database": "PDB",
"url": ""
},
{
"id": "5RXF",
"database": "PDB",
"url": ""
},
{
"id": "5RWC",
"database": "PDB",
"url": ""
},
{
"id": "1455",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "5RY3",
"database": "PDB",
"url": ""
},
{
"id": "5RWY",
"database": "PDB",
"url": ""
},
{
"id": "5RY1",
"database": "PDB",
"url": ""
},
{
"id": "5RWW",
"database": "PDB",
"url": ""
},
{
"id": "5RY2",
"database": "PDB",
"url": ""
},
{
"id": "5RWX",
"database": "PDB",
"url": ""
},
{
"id": "5RY5",
"database": "PDB",
"url": ""
},
{
"id": "5RX1",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP03787",
"database": "HMDB Protein",
"url": ""
},
{
"id": "5RY6",
"database": "PDB",
"url": ""
},
{
"id": "5RX0",
"database": "PDB",
"url": ""
},
{
"id": "3.1.3.86",
"database": "IntEnz",
"url": ""
},
{
"id": "5RY4",
"database": "PDB",
"url": ""
},
{
"id": "5RWZ",
"database": "PDB",
"url": ""
},
{
"id": "5RY8",
"database": "PDB",
"url": ""
},
{
"id": "5RX3",
"database": "PDB",
"url": ""
},
{
"id": "5RW2",
"database": "PDB",
"url": ""
},
{
"id": "5RY7",
"database": "PDB",
"url": ""
},
{
"id": "5RX2",
"database": "PDB",
"url": ""
},
{
"id": "2YSX",
"database": "PDB",
"url": ""
},
{
"id": "5RYA",
"database": "PDB",
"url": ""
},
{
"id": "5RWU",
"database": "PDB",
"url": ""
},
{
"id": "5RXZ",
"database": "PDB",
"url": ""
},
{
"id": "5RWV",
"database": "PDB",
"url": ""
},
{
"id": "5RY0",
"database": "PDB",
"url": ""
},
{
"id": "5RWS",
"database": "PDB",
"url": ""
},
{
"id": "5RXY",
"database": "PDB",
"url": ""
},
{
"id": "5RXX",
"database": "PDB",
"url": ""
},
{
"id": "5RWT",
"database": "PDB",
"url": ""
},
{
"id": "5RXV",
"database": "PDB",
"url": ""
},
{
"id": "5RWQ",
"database": "PDB",
"url": ""
},
{
"id": "5RXW",
"database": "PDB",
"url": ""
},
{
"id": "5RWR",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000445964",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000168918",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000629761",
"database": "Ensembl",
"url": ""
},
{
"id": "5RWN",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000405338",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000630854",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000486669",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000487191",
"database": "Ensembl",
"url": ""
},
{
"id": "Q92835",
"database": "GeneCards",
"url": ""
},
{
"id": "5RXU",
"database": "PDB",
"url": ""
},
{
"id": "5RXT",
"database": "PDB",
"url": ""
},
{
"id": "5RWP",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000352575",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000281614",
"database": "Ensembl",
"url": ""
},
{
"id": "5RWO",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000359570",
"database": "Ensembl",
"url": ""
},
{
"id": "5RX4",
"database": "PDB",
"url": ""
},
{
"id": "5RW3",
"database": "PDB",
"url": ""
},
{
"id": "5RX5",
"database": "PDB",
"url": ""
},
{
"id": "5RY9",
"database": "PDB",
"url": ""
},
{
"id": "5RW4",
"database": "PDB",
"url": ""
},
{
"id": "5RX6",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-200917",
"participant_name": "FYN [cytosol]",
"crossref": [
{
"id": "P06241",
"database": "UniProt",
"url": ""
},
{
"id": "P06241",
"database": "PRO",
"url": ""
},
{
"id": "FYN_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "3H0H",
"database": "PDB",
"url": ""
},
{
"id": "FYN_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "2026",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "7A2N",
"database": "PDB",
"url": ""
},
{
"id": "1AOT",
"database": "PDB",
"url": ""
},
{
"id": "1A0N",
"database": "PDB",
"url": ""
},
{
"id": "XP_016866139.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3H0F",
"database": "PDB",
"url": ""
},
{
"id": "FYN_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "7A2M",
"database": "PDB",
"url": ""
},
{
"id": "7A2P",
"database": "PDB",
"url": ""
},
{
"id": "XP_016866141.1",
"database": "RefSeq",
"url": ""
},
{
"id": "3UA6",
"database": "PDB",
"url": ""
},
{
"id": "1AVZ",
"database": "PDB",
"url": ""
},
{
"id": "7A2O",
"database": "PDB",
"url": ""
},
{
"id": "3H0I",
"database": "PDB",
"url": ""
},
{
"id": "1AOU",
"database": "PDB",
"url": ""
},
{
"id": "XP_016866140.1",
"database": "RefSeq",
"url": ""
},
{
"id": "FYN_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "7A2R",
"database": "PDB",
"url": ""
},
{
"id": "1FYN",
"database": "PDB",
"url": ""
},
{
"id": "4D8D",
"database": "PDB",
"url": ""
},
{
"id": "1EFN",
"database": "PDB",
"url": ""
},
{
"id": "FYN_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "XP_016866142.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7A2Q",
"database": "PDB",
"url": ""
},
{
"id": "3UA7",
"database": "PDB",
"url": ""
},
{
"id": "1AZG",
"database": "PDB",
"url": ""
},
{
"id": "7A2T",
"database": "PDB",
"url": ""
},
{
"id": "1M27",
"database": "PDB",
"url": ""
},
{
"id": "4U17",
"database": "PDB",
"url": ""
},
{
"id": "7A2S",
"database": "PDB",
"url": ""
},
{
"id": "1G83",
"database": "PDB",
"url": ""
},
{
"id": "XP_016866143.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4EIK",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000357667",
"database": "Ensembl",
"url": ""
},
{
"id": "1NYG",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000368667",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_694592.1",
"database": "RefSeq",
"url": ""
},
{
"id": "P06241",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000010810",
"database": "Ensembl",
"url": ""
},
{
"id": "7A2V",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000357656",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000229471",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000368678",
"database": "Ensembl",
"url": ""
},
{
"id": "4ZNX",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000354650",
"database": "Ensembl",
"url": ""
},
{
"id": "1NYF",
"database": "PDB",
"url": ""
},
{
"id": "7A2U",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000357671",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000346671",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000229471",
"database": "Ensembl",
"url": ""
},
{
"id": "4U1P",
"database": "PDB",
"url": ""
},
{
"id": "NP_002028.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000010810",
"database": "OpenTargets",
"url": ""
},
{
"id": "7A2K",
"database": "PDB",
"url": ""
},
{
"id": "7A2Z",
"database": "PDB",
"url": ""
},
{
"id": "2MRJ",
"database": "PDB",
"url": ""
},
{
"id": "2MRK",
"database": "PDB",
"url": ""
},
{
"id": "XP_005266949.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7A2L",
"database": "PDB",
"url": ""
},
{
"id": "2DQ7",
"database": "PDB",
"url": ""
},
{
"id": "6IPY",
"database": "PDB",
"url": ""
},
{
"id": "7A2X",
"database": "PDB",
"url": ""
},
{
"id": "FYN_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "6IPZ",
"database": "PDB",
"url": ""
},
{
"id": "7A2J",
"database": "PDB",
"url": ""
},
{
"id": "XP_005266947.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7A2Y",
"database": "PDB",
"url": ""
},
{
"id": "2MQI",
"database": "PDB",
"url": ""
},
{
"id": "P06241",
"database": "ZINC target",
"url": ""
},
{
"id": "1SHF",
"database": "PDB",
"url": ""
},
{
"id": "5ZAU",
"database": "PDB",
"url": ""
},
{
"id": "P06241",
"database": "GeneCards",
"url": ""
},
{
"id": "ENSG00000010810-FYN",
"database": "HPA",
"url": ""
},
{
"id": "FYN_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "1ZBJ",
"database": "PDB",
"url": ""
},
{
"id": "6EDF",
"database": "PDB",
"url": ""
},
{
"id": "7A2W",
"database": "PDB",
"url": ""
},
{
"id": "NP_694593.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENST00000368682",
"database": "Ensembl",
"url": ""
}
]
},
{
"participant_id": "R-HSA-202367",
"participant_name": "GRAP2 [cytosol]",
"crossref": [
{
"id": "O75791",
"database": "UniProt",
"url": ""
},
{
"id": "NP_004801.1",
"database": "RefSeq",
"url": ""
},
{
"id": "5GJH",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000100351",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000100351",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENST00000344138",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000385607",
"database": "Ensembl",
"url": ""
},
{
"id": "O75791",
"database": "PRO",
"url": ""
},
{
"id": "ENST00000407075",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000339186",
"database": "Ensembl",
"url": ""
},
{
"id": "O75791",
"database": "GeneCards",
"url": ""
},
{
"id": "NP_001278753.1",
"database": "RefSeq",
"url": ""
},
{
"id": "O75791",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000100351-GRAP2",
"database": "HPA",
"url": ""
},
{
"id": "NP_001278754.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001278757.1",
"database": "RefSeq",
"url": ""
}
]
},
{
"participant_id": "R-HSA-354251",
"participant_name": "LYN [cytosol]",
"crossref": [
{
"id": "P07948",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000428424",
"database": "Ensembl",
"url": ""
},
{
"id": "XP_016868905.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000254087",
"database": "Ensembl",
"url": ""
},
{
"id": "P07948",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000519728",
"database": "Ensembl",
"url": ""
},
{
"id": "LYN_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "LYN_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "ENST00000520220",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000428924",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001104567.1",
"database": "RefSeq",
"url": ""
},
{
"id": "LYN_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "NP_002341.1",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSG00000254087",
"database": "OpenTargets",
"url": ""
},
{
"id": "HMDBP13811",
"database": "HMDB Protein",
"url": ""
},
{
"id": "2.7.10.2",
"database": "IntEnz",
"url": ""
},
{
"id": "LYN_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "P07948",
"database": "ZINC target",
"url": ""
},
{
"id": "2060",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "P07948",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000254087-LYN",
"database": "HPA",
"url": ""
},
{
"id": "LYN_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "LYN_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "3A4O",
"database": "PDB",
"url": ""
},
{
"id": "1WA7",
"database": "PDB",
"url": ""
},
{
"id": "1W1F",
"database": "PDB",
"url": ""
},
{
"id": "6NMW",
"database": "PDB",
"url": ""
},
{
"id": "P07948",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "5XY1",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-373640",
"participant_name": "YES1 [cytosol]",
"crossref": [
{
"id": "P07947",
"database": "UniProt",
"url": ""
},
{
"id": "P07947",
"database": "PRO",
"url": ""
},
{
"id": "2284",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "XP_016881449.1",
"database": "RefSeq",
"url": ""
},
{
"id": "2HDA",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000462468",
"database": "Ensembl",
"url": ""
},
{
"id": "HMDBP01230",
"database": "HMDB Protein",
"url": ""
},
{
"id": "ENSG00000176105",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000584307",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000176105",
"database": "OpenTargets",
"url": ""
},
{
"id": "P07947",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000314574",
"database": "Ensembl",
"url": ""
},
{
"id": "YES_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "ENSP00000324740",
"database": "Ensembl",
"url": ""
},
{
"id": "YES_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "YES_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "YES_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "YES_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "YES_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "NP_005424.1",
"database": "RefSeq",
"url": ""
},
{
"id": "P07947",
"database": "ZINC target",
"url": ""
},
{
"id": "P07947",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000176105-YES1",
"database": "HPA",
"url": ""
}
]
},
{
"participant_id": "R-HSA-913354",
"participant_name": "INPPL1 [cytosol]",
"crossref": [
{
"id": "O15357",
"database": "UniProt",
"url": ""
},
{
"id": "O15357",
"database": "GeneCards",
"url": ""
},
{
"id": "5OKO",
"database": "PDB",
"url": ""
},
{
"id": "5OKP",
"database": "PDB",
"url": ""
},
{
"id": "5OKN",
"database": "PDB",
"url": ""
},
{
"id": "O15357",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "6SQU",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000444619",
"database": "Ensembl",
"url": ""
},
{
"id": "3NR8",
"database": "PDB",
"url": ""
},
{
"id": "XP_011543301.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4A9C",
"database": "PDB",
"url": ""
},
{
"id": "1459",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "ENST00000538751",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000165458",
"database": "OpenTargets",
"url": ""
},
{
"id": "ENSG00000165458",
"database": "Ensembl",
"url": ""
},
{
"id": "5OKM",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000298229",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000298229",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000165458-INPPL1",
"database": "HPA",
"url": ""
},
{
"id": "2KSO",
"database": "PDB",
"url": ""
},
{
"id": "2K4P",
"database": "PDB",
"url": ""
},
{
"id": "2MK2",
"database": "PDB",
"url": ""
},
{
"id": "NP_001558.3",
"database": "RefSeq",
"url": ""
},
{
"id": "6SRR",
"database": "PDB",
"url": ""
},
{
"id": "HMDBP03264",
"database": "HMDB Protein",
"url": ""
},
{
"id": "O15357",
"database": "ZINC target",
"url": ""
},
{
"id": "O15357",
"database": "PRO",
"url": ""
},
{
"id": "21752",
"database": "Orphanet",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9628701",
"participant_name": "SRC [cytosol]",
"crossref": [
{
"id": "P12931",
"database": "UniProt",
"url": ""
},
{
"id": "2BDJ",
"database": "PDB",
"url": ""
},
{
"id": "NP_938033.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4MXO",
"database": "PDB",
"url": ""
},
{
"id": "1O4C",
"database": "PDB",
"url": ""
},
{
"id": "XP_011527315.1",
"database": "RefSeq",
"url": ""
},
{
"id": "4MXX",
"database": "PDB",
"url": ""
},
{
"id": "1O4D",
"database": "PDB",
"url": ""
},
{
"id": "1O42",
"database": "PDB",
"url": ""
},
{
"id": "1O4O",
"database": "PDB",
"url": ""
},
{
"id": "1A07",
"database": "PDB",
"url": ""
},
{
"id": "1O43",
"database": "PDB",
"url": ""
},
{
"id": "P12931",
"database": "ZINC target",
"url": ""
},
{
"id": "4MXY",
"database": "PDB",
"url": ""
},
{
"id": "1O4E",
"database": "PDB",
"url": ""
},
{
"id": "1A08",
"database": "PDB",
"url": ""
},
{
"id": "XP_016883513.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1O4P",
"database": "PDB",
"url": ""
},
{
"id": "2H8H",
"database": "PDB",
"url": ""
},
{
"id": "25273",
"database": "Orphanet",
"url": ""
},
{
"id": "1A09",
"database": "PDB",
"url": ""
},
{
"id": "SRC_HUMAN",
"database": "ZINC - FDA approved",
"url": ""
},
{
"id": "2206",
"database": "Guide to Pharmacology - Targets",
"url": ""
},
{
"id": "2SRC",
"database": "PDB",
"url": ""
},
{
"id": "XP_016883514.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1O4L",
"database": "PDB",
"url": ""
},
{
"id": "1YOL",
"database": "PDB",
"url": ""
},
{
"id": "7OTE",
"database": "PDB",
"url": ""
},
{
"id": "4F5B",
"database": "PDB",
"url": ""
},
{
"id": "7T1U",
"database": "PDB",
"url": ""
},
{
"id": "1YOM",
"database": "PDB",
"url": ""
},
{
"id": "4HXJ",
"database": "PDB",
"url": ""
},
{
"id": "SRC_HUMAN",
"database": "ZINC - Investigational",
"url": ""
},
{
"id": "1O4A",
"database": "PDB",
"url": ""
},
{
"id": "1HCT",
"database": "PDB",
"url": ""
},
{
"id": "4K11",
"database": "PDB",
"url": ""
},
{
"id": "1O4B",
"database": "PDB",
"url": ""
},
{
"id": "1KSW",
"database": "PDB",
"url": ""
},
{
"id": "1O4M",
"database": "PDB",
"url": ""
},
{
"id": "SRC_HUMAN",
"database": "ZINC - Metabolites",
"url": ""
},
{
"id": "NP_005408.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1O41",
"database": "PDB",
"url": ""
},
{
"id": "1O4N",
"database": "PDB",
"url": ""
},
{
"id": "2BDF",
"database": "PDB",
"url": ""
},
{
"id": "P12931",
"database": "GeneCards",
"url": ""
},
{
"id": "1O47",
"database": "PDB",
"url": ""
},
{
"id": "1O4I",
"database": "PDB",
"url": ""
},
{
"id": "1A1E",
"database": "PDB",
"url": ""
},
{
"id": "6E6E",
"database": "PDB",
"url": ""
},
{
"id": "1Y57",
"database": "PDB",
"url": ""
},
{
"id": "6EHJ",
"database": "PDB",
"url": ""
},
{
"id": "1YI6",
"database": "PDB",
"url": ""
},
{
"id": "P12931",
"database": "PRO",
"url": ""
},
{
"id": "4F59",
"database": "PDB",
"url": ""
},
{
"id": "1YOJ",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000197122",
"database": "OpenTargets",
"url": ""
},
{
"id": "4F5A",
"database": "PDB",
"url": ""
},
{
"id": "1O48",
"database": "PDB",
"url": ""
},
{
"id": "1O4J",
"database": "PDB",
"url": ""
},
{
"id": "1FMK",
"database": "PDB",
"url": ""
},
{
"id": "1O49",
"database": "PDB",
"url": ""
},
{
"id": "1O4K",
"database": "PDB",
"url": ""
},
{
"id": "1HCS",
"database": "PDB",
"url": ""
},
{
"id": "SRC_HUMAN",
"database": "ZINC - Predictions - Purchasable",
"url": ""
},
{
"id": "7NG7",
"database": "PDB",
"url": ""
},
{
"id": "3VRO",
"database": "PDB",
"url": ""
},
{
"id": "1A1A",
"database": "PDB",
"url": ""
},
{
"id": "1O4F",
"database": "PDB",
"url": ""
},
{
"id": "XP_016883515.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1O44",
"database": "PDB",
"url": ""
},
{
"id": "P12931",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "1O4Q",
"database": "PDB",
"url": ""
},
{
"id": "SRC_HUMAN",
"database": "ZINC - Biogenic",
"url": ""
},
{
"id": "ENST00000373578",
"database": "Ensembl",
"url": ""
},
{
"id": "1O4H",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000373567",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000508666",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000509325",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000362680",
"database": "Ensembl",
"url": ""
},
{
"id": "1O46",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000197122",
"database": "Ensembl",
"url": ""
},
{
"id": "1A1C",
"database": "PDB",
"url": ""
},
{
"id": "ENSP00000362668",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000362659",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000692423",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000692112",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000350941",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000373558",
"database": "Ensembl",
"url": ""
},
{
"id": "3ZMQ",
"database": "PDB",
"url": ""
},
{
"id": "ENST00000358208",
"database": "Ensembl",
"url": ""
},
{
"id": "3ZMP",
"database": "PDB",
"url": ""
},
{
"id": "1A1B",
"database": "PDB",
"url": ""
},
{
"id": "ENSG00000197122-SRC",
"database": "HPA",
"url": ""
},
{
"id": "SRC_HUMAN",
"database": "ZINC - World Drugs",
"url": ""
},
{
"id": "6C4S",
"database": "PDB",
"url": ""
},
{
"id": "1SHD",
"database": "PDB",
"url": ""
},
{
"id": "1O4R",
"database": "PDB",
"url": ""
},
{
"id": "6ATE",
"database": "PDB",
"url": ""
},
{
"id": "XP_016883516.1",
"database": "RefSeq",
"url": ""
},
{
"id": "1O4G",
"database": "PDB",
"url": ""
},
{
"id": "SRC_HUMAN",
"database": "ZINC - Substances",
"url": ""
},
{
"id": "1O45",
"database": "PDB",
"url": ""
},
{
"id": "4MXZ",
"database": "PDB",
"url": ""
}
]
},
{
"participant_id": "R-HSA-9682751",
"participant_name": "THOC5 [cytosol]",
"crossref": [
{
"id": "Q13769",
"database": "UniProt",
"url": ""
},
{
"id": "ENSP00000380970",
"database": "Ensembl",
"url": ""
},
{
"id": "7ZNL",
"database": "PDB",
"url": ""
},
{
"id": "Q13769",
"database": "GeneCards",
"url": ""
},
{
"id": "ENST00000397873",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000380971",
"database": "Ensembl",
"url": ""
},
{
"id": "Q13769",
"database": "Pharos - Targets",
"url": ""
},
{
"id": "ENSG00000100296-THOC5",
"database": "HPA",
"url": ""
},
{
"id": "ENST00000490103",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSG00000100296",
"database": "Ensembl",
"url": ""
},
{
"id": "ENSP00000420306",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_003669.4",
"database": "RefSeq",
"url": ""
},
{
"id": "ENSP00000380969",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000397872",
"database": "Ensembl",
"url": ""
},
{
"id": "ENST00000397871",
"database": "Ensembl",
"url": ""
},
{
"id": "NP_001002877.1",
"database": "RefSeq",
"url": ""
},
{
"id": "7APK",
"database": "PDB",
"url": ""
},
{
"id": "Q13769",
"database": "PRO",
"url": ""
},
{
"id": "ENSG00000100296",
"database": "OpenTargets",
"url": ""
},
{
"id": "HMDBP14137",
"database": "HMDB Protein",
"url": ""
},
{
"id": "7ZNK",
"database": "PDB",
"url": ""
},
{
"id": "NP_001002878.1",
"database": "RefSeq",
"url": ""
},
{
"id": "NP_001002879.1",
"database": "RefSeq",
"url": ""
}
]
}
],
"reaction_enzymes": [
{
"uniprot_ac": "D3ZGS3",
"gene_name": "Ocrl",
"activity": [
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "D3ZGS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZGS3"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "D3ZGS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZGS3"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "D3ZGS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZGS3"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "D3ZGS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZGS3"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "D3ZGS3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/D3ZGS3"
}
]
}
]
},
{
"uniprot_ac": "O15357",
"gene_name": "INPPL1",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "O15357",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15357"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "O15357",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O15357"
}
]
}
]
},
{
"uniprot_ac": "O43426",
"gene_name": "SYNJ1",
"activity": [
{
"ec_number": "3.1.3.64",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate.",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
},
{
"ec_number": "3.1.3.64",
"activity": "",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "O43426",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O43426"
}
]
}
]
},
{
"uniprot_ac": "O60674",
"gene_name": "JAK2",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "O60674",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60674"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "O60674",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/O60674"
}
]
}
]
},
{
"uniprot_ac": "P06241",
"gene_name": "FYN",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P06241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06241"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P06241",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P06241"
}
]
}
]
},
{
"uniprot_ac": "P07333",
"gene_name": "CSF1R",
"activity": [
{
"ec_number": "2.7.10.1",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P07333",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07333"
}
]
},
{
"ec_number": "2.7.10.1",
"activity": "",
"evidence": [
{
"id": "P07333",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07333"
}
]
}
]
},
{
"uniprot_ac": "P07947",
"gene_name": "YES1",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P07947",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07947"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P07947",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07947"
}
]
}
]
},
{
"uniprot_ac": "P07948",
"gene_name": "LYN",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P07948",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07948"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P07948",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P07948"
}
]
}
]
},
{
"uniprot_ac": "P08631",
"gene_name": "HCK",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P08631",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08631"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P08631",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P08631"
}
]
}
]
},
{
"uniprot_ac": "P12931",
"gene_name": "SRC",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P12931",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12931"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P12931",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P12931"
}
]
}
]
},
{
"uniprot_ac": "P16885",
"gene_name": "PLCG2",
"activity": [
{
"ec_number": "3.1.4.11",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+).",
"evidence": [
{
"id": "P16885",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16885"
}
]
},
{
"ec_number": "3.1.4.11",
"activity": "",
"evidence": [
{
"id": "P16885",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P16885"
}
]
}
]
},
{
"uniprot_ac": "P22681",
"gene_name": "CBL",
"activity": [
{
"ec_number": "2.3.2.27",
"activity": "S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.",
"evidence": [
{
"id": "P22681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22681"
}
]
},
{
"ec_number": "2.3.2.27",
"activity": "",
"evidence": [
{
"id": "P22681",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P22681"
}
]
}
]
},
{
"uniprot_ac": "P23458",
"gene_name": "JAK1",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P23458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23458"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P23458",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P23458"
}
]
}
]
},
{
"uniprot_ac": "P42336",
"gene_name": "PIK3CA",
"activity": [
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "P42336",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42336"
}
]
}
]
},
{
"uniprot_ac": "P42338",
"gene_name": "PIK3CB",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "P42338",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P42338"
}
]
}
]
},
{
"uniprot_ac": "P48736",
"gene_name": "PIK3CG",
"activity": [
{
"ec_number": "2.7.11.1",
"activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+).",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+).",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.153",
"activity": "",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.137",
"activity": "",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
},
{
"ec_number": "2.7.1.154",
"activity": "",
"evidence": [
{
"id": "P48736",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P48736"
}
]
}
]
},
{
"uniprot_ac": "P52333",
"gene_name": "JAK3",
"activity": [
{
"ec_number": "2.7.10.2",
"activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].",
"evidence": [
{
"id": "P52333",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52333"
}
]
},
{
"ec_number": "2.7.10.2",
"activity": "",
"evidence": [
{
"id": "P52333",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P52333"
}
]
}
]
},
{
"uniprot_ac": "P97573",
"gene_name": "Inpp5d",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "P97573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97573"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "P97573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97573"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "P97573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97573"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "P97573",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/P97573"
}
]
}
]
},
{
"uniprot_ac": "Q01968",
"gene_name": "OCRL",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q01968",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q01968"
}
]
}
]
},
{
"uniprot_ac": "Q06124",
"gene_name": "PTPN11",
"activity": [
{
"ec_number": "3.1.3.48",
"activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q06124",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06124"
}
]
},
{
"ec_number": "3.1.3.48",
"activity": "",
"evidence": [
{
"id": "Q06124",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q06124"
}
]
}
]
},
{
"uniprot_ac": "Q13572",
"gene_name": "ITPK1",
"activity": [
{
"ec_number": "2.7.1.134",
"activity": "1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+).",
"evidence": [
{
"id": "Q13572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13572"
}
]
},
{
"ec_number": "2.7.1.159",
"activity": "1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+).",
"evidence": [
{
"id": "Q13572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13572"
}
]
},
{
"ec_number": "2.7.1.134",
"activity": "",
"evidence": [
{
"id": "Q13572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13572"
}
]
},
{
"ec_number": "2.7.1.159",
"activity": "",
"evidence": [
{
"id": "Q13572",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q13572"
}
]
}
]
},
{
"uniprot_ac": "Q15735",
"gene_name": "INPP5J",
"activity": [
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q15735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15735"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "Q15735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15735"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q15735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15735"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q15735",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q15735"
}
]
}
]
},
{
"uniprot_ac": "Q6NVF0",
"gene_name": "Ocrl",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q6NVF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NVF0"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q6NVF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NVF0"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q6NVF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NVF0"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "Q6NVF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NVF0"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q6NVF0",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6NVF0"
}
]
}
]
},
{
"uniprot_ac": "Q6P549",
"gene_name": "Inppl1",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q6P549",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P549"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "Q6P549",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q6P549"
}
]
}
]
},
{
"uniprot_ac": "Q8C5L6",
"gene_name": "Inpp5k",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q8C5L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C5L6"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q8C5L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C5L6"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q8C5L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C5L6"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "Q8C5L6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q8C5L6"
}
]
}
]
},
{
"uniprot_ac": "Q91WF7",
"gene_name": "Fig4",
"activity": [
{
"ec_number": "3.1.3.-",
"activity": "",
"evidence": [
{
"id": "Q91WF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WF7"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q91WF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WF7"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q91WF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WF7"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q91WF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WF7"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "Q91WF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WF7"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q91WF7",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q91WF7"
}
]
}
]
},
{
"uniprot_ac": "Q92562",
"gene_name": "FIG4",
"activity": [
{
"ec_number": "3.1.3.-",
"activity": "",
"evidence": [
{
"id": "Q92562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92562"
}
]
},
{
"ec_number": "3.1.3.16",
"activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.",
"evidence": [
{
"id": "Q92562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92562"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q92562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92562"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q92562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92562"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q92562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92562"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "Q92562",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92562"
}
]
}
]
},
{
"uniprot_ac": "Q92835",
"gene_name": "INPP5D",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q92835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92835"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q92835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92835"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q92835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92835"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "Q92835",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q92835"
}
]
}
]
},
{
"uniprot_ac": "Q9BT40",
"gene_name": "INPP5K",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q9BT40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BT40"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q9BT40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BT40"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q9BT40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BT40"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "",
"evidence": [
{
"id": "Q9BT40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BT40"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "",
"evidence": [
{
"id": "Q9BT40",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9BT40"
}
]
}
]
},
{
"uniprot_ac": "Q9ES52",
"gene_name": "Inpp5d",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q9ES52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES52"
}
]
},
{
"ec_number": "3.1.3.56",
"activity": "1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate.",
"evidence": [
{
"id": "Q9ES52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES52"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q9ES52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES52"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "Q9ES52",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9ES52"
}
]
}
]
},
{
"uniprot_ac": "Q9JII1",
"gene_name": "Inpp5e",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q9JII1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JII1"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q9JII1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9JII1"
}
]
}
]
},
{
"uniprot_ac": "Q9NRR6",
"gene_name": "INPP5E",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q9NRR6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRR6"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q9NRR6",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9NRR6"
}
]
}
]
},
{
"uniprot_ac": "Q9WVR1",
"gene_name": "Inpp5e",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q9WVR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVR1"
}
]
},
{
"ec_number": "3.1.3.36",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.",
"evidence": [
{
"id": "Q9WVR1",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVR1"
}
]
}
]
},
{
"uniprot_ac": "Q9WVR3",
"gene_name": "Inppl1",
"activity": [
{
"ec_number": "3.1.3.86",
"activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.",
"evidence": [
{
"id": "Q9WVR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVR3"
}
]
},
{
"ec_number": "3.1.3.86",
"activity": "",
"evidence": [
{
"id": "Q9WVR3",
"database": "UniProtKB",
"url": "https://www.uniprot.org/uniprot/Q9WVR3"
}
]
}
]
}
],
"biomarkers": [],
"synthesized_glycans": [],
"cluster_types": [
{
"name": "isoformset.uniprotkb",
"label": "Isoforms"
},
{
"name": "homologset.mgi",
"label": "MGI Homologs"
},
{
"name": "homologset.oma",
"label": "OMA Homologs"
}
],
"sequence_features": {
"n_linked_sites": [],
"o_linked_sites": [
276
],
"snv_sites": [
149,
267,
276,
290,
686,
717,
741,
778,
785,
792,
938,
984
],
"glycation_sites": [],
"phosphorylation_sites": [
132,
158,
165,
167,
240,
241,
290,
291,
352,
671,
827,
886,
890,
958,
986,
987,
1003,
1038,
1039,
1061,
1068,
1131,
1135,
1162,
1257
],
"sequon_annotation_sites": [
{
"start_pos": 441,
"end_pos": 443
},
{
"start_pos": 551,
"end_pos": 553
}
]
},
"section_stats": [
{
"table_id": "glycosylation",
"table_stats": [
{
"field": "total",
"count": 2
},
{
"field": "total_sites",
"count": 1
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 2
},
{
"field": "o_linked_glycan_sites",
"count": 1
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_reported",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_reported_with_glycan",
"table_stats": [
{
"field": "total",
"count": 2
},
{
"field": "total_sites",
"count": 1
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 2
},
{
"field": "o_linked_glycan_sites",
"count": 1
}
],
"sort_fields": [
"glytoucan_ac",
"type",
"subtype",
"site_category",
"site_seq",
"relation",
"comment",
"start_pos",
"start_aa",
"end_pos",
"end_aa",
"residue",
"site_lbl"
]
},
{
"table_id": "glycosylation_predicted",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "glycosylation_automatic_literature_mining",
"table_stats": [
{
"field": "total",
"count": 0
},
{
"field": "total_sites",
"count": 0
},
{
"field": "n_linked_glycans",
"count": 0
},
{
"field": "n_linked_glycan_sites",
"count": 0
},
{
"field": "o_linked_glycans",
"count": 0
},
{
"field": "o_linked_glycan_sites",
"count": 0
}
],
"sort_fields": []
},
{
"table_id": "phosphorylation",
"table_stats": [
{
"field": "total",
"count": 27
},
{
"field": "total_sites",
"count": 25
}
],
"sort_fields": [
"start_pos",
"end_pos",
"kinase_uniprot_canonical_ac",
"kinase_gene_name",
"residue",
"comment",
"site_lbl"
]
},
{
"table_id": "snv",
"table_stats": [
{
"field": "total",
"count": 13
},
{
"field": "total_sites",
"count": 12
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "snv_disease",
"table_stats": [
{
"field": "total",
"count": 3
},
{
"field": "total_sites",
"count": 3
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "snv_non_disease",
"table_stats": [
{
"field": "total",
"count": 10
},
{
"field": "total_sites",
"count": 9
}
],
"sort_fields": [
"start_pos",
"end_pos",
"sequence_org",
"sequence_mut",
"comment",
"chr_id",
"chr_pos",
"ref_nt",
"alt_nt",
"minor_allelic_frequency",
"site_lbl",
"subjects_tested",
"subjects_positive",
"frequency"
]
},
{
"table_id": "publication",
"table_stats": [
{
"field": "total",
"count": 181
}
],
"sort_fields": [
"title",
"journal",
"date",
"authors"
]
}
]
}