{ "uniprot_canonical_ac": "O15354-1", "uniprot_ac": "O15354", "uniprot_id": "GPR37_HUMAN", "mass": { "chemical_mass": 67114.0, "monoisotopic_mass": 67114.0 }, "refseq": { "ac": "NP_005293", "name": "prosaposin receptor GPR37 precursor", "summary": "This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293" }, "gene_names": [ { "name": "GPR37", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15354", "id": "O15354" }, { "name": "EDNRBL; hET(B)R-LP; PAELR", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293", "id": "NP_005293" }, { "name": "GPR37", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293", "id": "NP_005293" } ], "protein_names": [ { "name": "Prosaposin receptor GPR37", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15354" }, { "name": "ETBR-LP-1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15354" }, { "name": "Endothelin B receptor-like protein 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15354" }, { "name": "G-protein coupled receptor 37", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15354" }, { "name": "PAELR", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15354" }, { "name": "Parkin-associated endothelin receptor-like receptor; G protein-coupled receptor 37 (endothelin receptor type B-like); probable G-protein coupled receptor 37; ETBR-LP-1; endothelin B receptor-like protein 1; prosaposin receptor GPR37", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293", "id": "NP_005293" }, { "name": "Parkin-associated endothelin receptor-like receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15354" }, { "name": "prosaposin receptor GPR37 precursor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293", "id": "NP_005293" } ], "function": [ { "annotation": "Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer.", "evidence": [ { "database": "RefSeq", "id": "NP_005293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293" }, { "database": "PubMed", "id": "37732632", "url": "https://glygen.org/publication/PubMed/37732632" } ] }, { "annotation": "Ecto-GPR37: a potential biomarker for Parkinson's disease. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_005293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293" }, { "database": "PubMed", "id": "33637132", "url": "https://glygen.org/publication/PubMed/33637132" } ] }, { "annotation": "G-protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (By similarity). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (PubMed:11439185, PubMed:23690594). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway. Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination. Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain. In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection. Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (By similarity). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (PubMed:28341812).", "evidence": [ { "database": "UniProtKB", "id": "O15354", "url": "https://www.uniprot.org/uniprot/O15354#function" }, { "database": "PubMed", "id": "23690594", "url": "https://glygen.org/publication/PubMed/23690594" }, { "database": "PubMed", "id": "11439185", "url": "https://glygen.org/publication/PubMed/11439185" }, { "database": "PubMed", "id": "9526070", "url": "https://glygen.org/publication/PubMed/9526070" }, { "database": "PubMed", "id": "25977097", "url": "https://glygen.org/publication/PubMed/25977097" }, { "database": "PubMed", "id": "28341812", "url": "https://glygen.org/publication/PubMed/28341812" }, { "database": "UniProtKB", "id": "Q9QY42", "url": "https://www.uniprot.org/uniprot/Q9QY42#function" } ] }, { "annotation": "GPR37 promotes cancer growth by binding to CDK6 and represents a new theranostic target in lung adenocarcinoma.", "evidence": [ { "database": "RefSeq", "id": "NP_005293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293" }, { "database": "PubMed", "id": "35934193", "url": "https://glygen.org/publication/PubMed/35934193" } ] }, { "annotation": "GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_005293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293" }, { "database": "PubMed", "id": "37749229", "url": "https://glygen.org/publication/PubMed/37749229" } ] }, { "annotation": "This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012].", "evidence": [ { "database": "RefSeq", "id": "NP_005293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005293" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs1192218160", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1192218160" }, { "id": "rs1192218160", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1192218160" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 139, "end_pos": 139, "sequence_org": "P", "sequence_mut": "A", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NPT->NAT).", "chr_id": "7", "chr_pos": "124764562", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "P139", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1243521536", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1243521536" }, { "id": "rs1243521536", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1243521536" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 224, "end_pos": 224, "sequence_org": "S", "sequence_mut": "Y", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NGS->NGY).", "chr_id": "7", "chr_pos": "124764306", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "S224", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1157007639", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1157007639" }, { "id": "rs1157007639", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1157007639" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 239, "end_pos": 239, "sequence_org": "N", "sequence_mut": "D", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NST->DST).", "chr_id": "7", "chr_pos": "124764262", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N239", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1352589527", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1352589527" }, { "id": "rs1352589527", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1352589527" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 241, "end_pos": 241, "sequence_org": "T", "sequence_mut": "R", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NST->NSR).", "chr_id": "7", "chr_pos": "124764255", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "T241", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1162999566", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1162999566" }, { "id": "rs1162999566", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1162999566#frequency_tab" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 244, "end_pos": 244, "sequence_org": "R", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NRR->NRS).", "chr_id": "7", "chr_pos": "124764247", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "R244", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O15354", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15354" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 304, "end_pos": 304, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NLA->NLT).", "chr_id": "7", "chr_pos": "124764067", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "A304", "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "LNCR3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "lung cancer susceptibility 3", "description": "" }, { "id": "MONDO:0012942", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012942", "name": "adenocarcinoma of lung, susceptibility to", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "LNCR4", "description": "" }, { "id": "MONDO:0012955", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012955", "name": "lung cancer susceptibility 4", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "LNCR5", "description": "" }, { "id": "MONDO:0013631", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0013631", "name": "lung cancer susceptibility 5", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "A malignant neoplasm involving the lung." }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "adenocarcinoma of lung, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "cancer of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, resistance to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung neoplasm", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumor", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant lung tumour", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant neoplasm of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumor of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "malignant tumour of the lung", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, somatic", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "nonsmall cell lung cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "Nonsmall cell lung cancer", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "alveolar cell carcinoma", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung cancer, protection against", "description": "" }, { "id": "MONDO:0008903", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008903", "name": "lung neoplasm", "description": "" }, { "id": "MIM:211980", "resource": "MIM", "url": "https://www.omim.org/entry/211980", "name": "Lung cancer", "description": "Lung cancer" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs867361879", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs867361879" }, { "id": "rs867361879", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs867361879" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 331, "end_pos": 331, "sequence_org": "D", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (DFS->NFS).", "chr_id": "7", "chr_pos": "124763986", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "D331", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O15354", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15354" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 36, "end_pos": 36, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "N", "sequence_mut": "K", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NET->KET).", "chr_id": "7", "chr_pos": "124764869", "ref_nt": "G", "alt_nt": "C", "minor_allelic_frequency": "", "site_lbl": "N36", "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease" ] }, { "evidence": [ { "id": "rs1478233984", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1478233984" }, { "id": "rs1478233984", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1478233984" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 63, "end_pos": 63, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NSA->NST).", "chr_id": "7", "chr_pos": "124764790", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "A63", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 54, "end_pos": 54, "sequence_org": "R", "sequence_mut": "A", "comment": "Strong increase of full-length receptor abundance at the cell surface.", "evidence": [ { "database": "UniProtKB", "id": "O15354", "url": "https://www.uniprot.org/uniprot/O15354" }, { "database": "PubMed", "id": "34042202", "url": "https://glygen.org/publication/PubMed/34042202" } ] }, { "start_pos": 558, "end_pos": 558, "sequence_org": "R", "sequence_mut": "Q", "comment": "Strong loss of interaction with MUPP1 resulting in dendritic alteration.", "evidence": [ { "database": "UniProtKB", "id": "O15354", "url": "https://www.uniprot.org/uniprot/O15354" }, { "database": "PubMed", "id": "25977097", "url": "https://glygen.org/publication/PubMed/25977097" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "54.59", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000170775", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170775" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "43.21", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000170775", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170775" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "47.11", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000170775", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170775" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000170775", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170775" } ] }, { "tissue": { "name": "Esophagus", "namespace": 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15354" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"MRAPGALLARMSRLLLLLLLKVSASSALGVAPASRNETCLGESCAPTVIQRRGRDAWGPGNSARDVLRARAPREEQGAAFLAGPSWDLPAAPGRDPAAGRGAEASAAGPPGPPTRPPGPWRWKGARGQEPSETLGRGNPTALQLFLQISEEEEKGPRGAGISGRSQEQSVKTVPGASDLFYWPRRAGKLQGSHHKPLSKTANGLAGHEGWTIALPGRALAQNGSLGEGIHEPGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGRAPAERCIIKISPDLPDTIYVLALTYDSARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKACTRGNKRQIQLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCKPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC", "length": 613, "header": "sp|O15354-1|GPR37_HUMAN Isoform 1 of Prosaposin receptor GPR37 OS=Homo sapiens OX=9606 GN=GPR37 PE=1 SV=2 CANONICAL=O15354-1" }, "locus": { "chromosome": "7", "start_pos": 124764976, "end_pos": 124746528, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000303921.3", "url": "https://www.ensembl.org/id/ENST00000303921.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000306449.2", "url": "https://www.ensembl.org/id/ENSP00000306449.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G57321FI", "type": "O-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "TVPGASDLFYWPR", "relation": "attached", "comment": "Data provided by GlycoDomainViewer", "start_pos": 172, "start_aa": "Thr", "end_pos": 184, "end_aa": "Arg", "evidence": [ { "id": "O15354", "database": "UniCarbKB", "url": "" }, { "id": "23584533", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/23584533" }, { "id": "10.1038/emboj.2013.79", "database": "DOI", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 222, "start_aa": "Asn", "end_pos": 222, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn222", "evidence": [ { "id": "O15354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15354#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 239, "start_aa": "Asn", "end_pos": 239, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn239", "evidence": [ { "id": "O15354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15354#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 36, "start_aa": "Asn", "end_pos": 36, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn36", "evidence": [ { "id": "O15354", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15354#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O15354", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15354" }, { "id": "37217939", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/37217939" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan", "glycoprotein_predicted" ], "publication": [ { "title": "Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology", "journal": "EMBO J", "date": "2013", "authors": "Steentoft C., Vakhrushev S.Y., Joshi H.J., Kong Y., Vester-Christensen M.B., Schjoldager K.T., Lavrsen K., Dabelsteen S., Pedersen N.B., Marcos-Silva L., Gupta R., Bennett E.P., Mandel U., Brunak S., Wandall H.H., Levery S.B., Clausen H.", "evidence": [ { "database": "UniCarbKB", "id": "O15354", "url": "" } ], "reference": [ { "type": "DOI", "id": "10.1038/emboj.2013.79", "url": "https://glygen.org/publication/DOI/10.1038/emboj.2013.79" } ] }, { "title": "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.", "journal": "The Journal of clinical investigation", "date": "1999", "authors": "Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR", "evidence": [ { "database": "Reactome", "id": "R-HSA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-375276" } ], "reference": [ { "type": "PubMed", "id": "10079109", "url": "https://glygen.org/publication/PubMed/10079109" } ] }, { "title": "Discovery of a receptor related to the galanin receptors.", "journal": "FEBS letters", "date": "1999", "authors": "Lee DK, Nguyen T, O'Neill GP, Cheng R, Liu Y, Howard AD, Coulombe N, Tan CP, Tang-Nguyen AT, George SR, O'Dowd BF", "evidence": [ { "database": "Reactome", "id": "R-HSA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-375276" } ], "reference": [ { "type": "PubMed", "id": "10100623", "url": "https://glygen.org/publication/PubMed/10100623" } ] }, { "title": "Receptor for motilin identified in the human gastrointestinal system.", "journal": "Science (New York, N.Y.)", "date": "1999", "authors": "Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, O'Neill G, Van Der Ploeg LH, Evans J, Patchett AA, Smith RG, Howard AD", "evidence": [ { "database": "Reactome", "id": "R-HSA-375276", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-375276" } ], "reference": [ { "type": "PubMed", "id": "10381885", "url": "https://glygen.org/publication/PubMed/10381885" } ] }, { "title": "Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.", "journal": "Nature", "date": "1999", "authors": "Chambers J, Ames RS, Bergsma D, Muir A, Fitzgerald LR, Hervieu G, Dytko GM, Foley 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