{ "uniprot_canonical_ac": "O15350-1", "uniprot_ac": "O15350", "uniprot_id": "P73_HUMAN", "mass": { "chemical_mass": 69623.0, "monoisotopic_mass": 69623.0 }, "refseq": { "ac": "NP_001119712", "name": "tumor protein p73 isoform b", "summary": "This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" }, "gene_names": [ { "name": "TP73", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15350", "id": "O15350" }, { "name": "CILD47; P73", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712", "id": "NP_001119712" }, { "name": "P73", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15350", "id": "O15350" }, { "name": "TP73", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712", "id": "NP_001119712" }, { "name": "hCG_19088", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15350", "id": "O15350" } ], "protein_names": [ { "name": "Tumor protein p73", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15350" }, { "name": "p53-like transcription factor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15350" }, { "name": "p53-related protein; p53-like transcription factor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712", "id": "NP_001119712" }, { "name": "p53-related protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15350" }, { "name": "tumor protein p73 isoform b", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712", "id": "NP_001119712" } ], "function": [ { "annotation": "Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.", "evidence": [ { "database": "UniProtKB", "id": "A0A0C4DFW9", "url": "https://www.uniprot.org/uniprot/A0A0C4DFW9#function" }, { "database": "UniProtKB", "id": "RU003304", "url": "https://www.uniprot.org/uniprot/RU003304#function" } ] }, { "annotation": "Clinical landscape of TP73 structural variants in ATL patients.", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" }, { "database": "PubMed", "id": "37864123", "url": "https://glygen.org/publication/PubMed/37864123" } ] }, { "annotation": "Lack of association of TP73 rare variants with amyotrophic lateral sclerosis in a Chinese cohort. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" }, { "database": "PubMed", "id": "36451215", "url": "https://glygen.org/publication/PubMed/36451215" } ] }, { "annotation": "Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" }, { "database": "PubMed", "id": "37931077", "url": "https://glygen.org/publication/PubMed/37931077" } ] }, { "annotation": "Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression (By similarity). It is an essential factor for the positive regulation of lung ciliated cell differentiation (PubMed:34077761).", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350#function" }, { "database": "PubMed", "id": "11753569", "url": "https://glygen.org/publication/PubMed/11753569" }, { "database": "PubMed", "id": "10203277", "url": "https://glygen.org/publication/PubMed/10203277" }, { "database": "PubMed", "id": "34077761", "url": "https://glygen.org/publication/PubMed/34077761" }, { "database": "UniProtKB", "id": "Q9JJP2", "url": "https://www.uniprot.org/uniprot/Q9JJP2#function" }, { "database": "PubMed", "id": "18174154", "url": "https://glygen.org/publication/PubMed/18174154" } ] }, { "annotation": "STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" }, { "database": "PubMed", "id": "36656267", "url": "https://glygen.org/publication/PubMed/36656267" } ] }, { "annotation": "TP73 gene is imprinted, with monoallelic expression likely from the maternal allele.", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" }, { "database": "PubMed", "id": "9288759", "url": "https://glygen.org/publication/PubMed/9288759" } ] }, { "annotation": "This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011].", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" } ] } ], "disease": [ { "disease_id": "MONDO:0030346", "recommended_name": { "id": "MONDO:0030346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030346", "name": "ciliary dyskinesia, primary, 47, and lissencephaly", "description": "" }, "synonyms": [ { "id": "MONDO:0030346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030346", "name": "CILD47", "description": "" }, { "id": "MONDO:0030346", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0030346", "name": "ciliary dyskinesia, primary, 47, and lissencephaly", "description": "" }, { "id": "MIM:619466", "resource": "MIM", "url": "https://www.omim.org/entry/619466", "name": "Ciliary dyskinesia, primary, 47, and lissencephaly", "description": "Ciliary dyskinesia, primary, 47, and lissencephaly" } ], "evidence": [ { "id": "619466", "database": "MIM", "url": "https://www.omim.org/entry/619466" } ] } ], "snv": [], "mutagenesis": [ { "start_pos": 27, "end_pos": 27, "sequence_org": "T", "sequence_mut": "A", "comment": "Impaired phosphorylation.", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "PubMed", "id": "18174154", "url": "https://glygen.org/publication/PubMed/18174154" } ] }, { "start_pos": 487, "end_pos": 487, "sequence_org": "Y", "sequence_mut": "A", "comment": "Loss of interaction with WWOX.", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "PubMed", "id": "15070730", "url": "https://glygen.org/publication/PubMed/15070730" } ] }, { "start_pos": 627, "end_pos": 627, "sequence_org": "K", "sequence_mut": "R", "comment": "Strongly diminishes sumoylation but does not affect transcriptional activity.", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "PubMed", "id": "10961991", "url": "https://glygen.org/publication/PubMed/10961991" } ] }, { "start_pos": 99, "end_pos": 99, "sequence_org": "Y", "sequence_mut": "F", "comment": "Impaired phosphorylation of isoform beta by ABL1.", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "PubMed", "id": "10391251", "url": "https://glygen.org/publication/PubMed/10391251" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "50.62", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "43.07", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "46.66", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "44.94", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "51.83", "present": "ABSENT", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "47.81", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "55.57", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "45.97", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "74.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "61.69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000078900", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000078900" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O15350", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15350" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "No", "trend": "up", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O15350", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15350" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", 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"name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "bladder cancer, somatic", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant neoplasm, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15350" } ], "disease": [ { "disease_id": "DOID:1324", "recommended_name": { "id": "DOID:1324", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1324", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." }, "synonyms": [ { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "LNCR1", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility", "description": "" }, { "id": "MONDO:0012159", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012159", "name": "lung cancer susceptibility 1", "description": 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"categories": [ "3D Structure" ] }, { "id": "4GUQ", "url": "https://www.rcsb.org/structure/4GUQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5HOB", "url": "https://www.rcsb.org/structure/5HOB", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5HOC", "url": "https://www.rcsb.org/structure/5HOC", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "5KBD", "url": "https://www.rcsb.org/structure/5KBD", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6FGS", "url": "https://www.rcsb.org/structure/6FGS", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "6IJQ", "url": "https://www.rcsb.org/structure/6IJQ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7EZJ", "url": "https://www.rcsb.org/structure/7EZJ", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00870", "url": "http://pfam.xfam.org/family/PF00870", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07647", "url": "http://pfam.xfam.org/family/PF07647", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07710", "url": "http://pfam.xfam.org/family/PF07710", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O15350", "url": "https://pharos.nih.gov/targets/O15350", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O15350", "url": "http://purl.obolibrary.org/obo/PR_O15350", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-139915", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-139915", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "R-HSA-8939236", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8939236", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0C4DFW9", "url": "https://www.uniprot.org/uniprot/A0A0C4DFW9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0C4DFW9-1", "url": "https://www.uniprot.org/uniprot/A0A0C4DFW9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-1", "url": "https://www.uniprot.org/uniprot/O15350-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-10", "url": "https://www.uniprot.org/uniprot/O15350-10", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-11", "url": "https://www.uniprot.org/uniprot/O15350-11", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-12", "url": "https://www.uniprot.org/uniprot/O15350-12", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-13", "url": "https://www.uniprot.org/uniprot/O15350-13", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-2", "url": "https://www.uniprot.org/uniprot/O15350-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-3", "url": "https://www.uniprot.org/uniprot/O15350-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-4", "url": "https://www.uniprot.org/uniprot/O15350-4", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-5", "url": "https://www.uniprot.org/uniprot/O15350-5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-6", "url": "https://www.uniprot.org/uniprot/O15350-6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-8", "url": "https://www.uniprot.org/uniprot/O15350-8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15350-9", "url": "https://www.uniprot.org/uniprot/O15350-9", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH", "length": 636, "header": "sp|O15350-1|P73_HUMAN Isoform 1 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "isoforms": [ { "isoform_ac": "A0A0C4DFW9-1", "url": "", "sequence": { "sequence": "MLYVGDPARHLATAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPRQFFNRIGVSKLHRVFHLPRVTEHLPPAEPDH", "length": 426, "header": "tr|A0A0C4DFW9-1|P73_HUMAN Computationally mapped isoform of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3731552, "end_pos": 3690906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378280.5", "url": "https://www.ensembl.org/id/ENST00000378280.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000367529.1", "url": "https://www.ensembl.org/id/ENSP00000367529.1" } ] } }, { "isoform_ac": "O15350-1", "url": "", "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH", "length": 636, "header": "sp|O15350-1|P73_HUMAN Isoform 1 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3733076, "end_pos": 3682366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378295.9", "url": "https://www.ensembl.org/id/ENST00000378295.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000367545.4", "url": "https://www.ensembl.org/id/ENSP00000367545.4" } ] } }, { "isoform_ac": "O15350-10", "url": "", "sequence": { "sequence": "MLYVGDPARHLATAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPRQFFNRIGVSKLHRVFHLPRVTEHLPPAEPDH", "length": 427, "header": "sp|O15350-10|P73_HUMAN Isoform 10 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": {} }, { "isoform_ac": "O15350-11", "url": "", "sequence": { "sequence": "MDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH", "length": 565, "header": "sp|O15350-11|P73_HUMAN Isoform 11 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3733076, "end_pos": 3707576, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378290.4", "url": "https://www.ensembl.org/id/ENST00000378290.4" }, { "database": "Ensembl Peptide", "id": "ENSP00000367539.4", "url": "https://www.ensembl.org/id/ENSP00000367539.4" } ] } }, { "isoform_ac": "O15350-12", "url": "", "sequence": { "sequence": "MLYVGDPARHLATAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRP", "length": 350, "header": "sp|O15350-12|P73_HUMAN Isoform 12 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": {} }, { "isoform_ac": "O15350-13", "url": "", "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPRQDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH", "length": 555, "header": "sp|O15350-13|P73_HUMAN Isoform 13 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3733076, "end_pos": 3682366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000603362.5", "url": "https://www.ensembl.org/id/ENST00000603362.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000474626.1", "url": "https://www.ensembl.org/id/ENSP00000474626.1" } ] } }, { "isoform_ac": "O15350-2", "url": "", "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVRTWGP", "length": 499, "header": "sp|O15350-2|P73_HUMAN Isoform 2 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3732759, "end_pos": 3682366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000354437.8", "url": "https://www.ensembl.org/id/ENST00000354437.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000346423.4", "url": "https://www.ensembl.org/id/ENSP00000346423.4" } ] } }, { "isoform_ac": "O15350-3", "url": "", "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPRQFFNRIGVSKLHRVFHLPRVTEHLPPAEPDH", "length": 476, "header": "sp|O15350-3|P73_HUMAN Isoform 3 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": {} }, { "isoform_ac": "O15350-4", "url": "", "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPTWGP", "length": 403, "header": "sp|O15350-4|P73_HUMAN Isoform 4 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3732759, "end_pos": 3682366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000604074.5", "url": "https://www.ensembl.org/id/ENST00000604074.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000475143.1", "url": "https://www.ensembl.org/id/ENSP00000475143.1" } ] } }, { "isoform_ac": "O15350-5", "url": "", "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPPRDAQQPWPRSASQQRRDEQQPQRPVHGLGVPLHSATPLPRRPQPRDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH", "length": 555, "header": "sp|O15350-5|P73_HUMAN Isoform 5 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": {} }, { "isoform_ac": "O15350-6", "url": "", "sequence": { "sequence": "MAQSTATSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTSVMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH", "length": 540, "header": "sp|O15350-6|P73_HUMAN Isoform 6 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3733076, "end_pos": 3682366, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000346387.8", "url": "https://www.ensembl.org/id/ENST00000346387.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000340740.4", "url": "https://www.ensembl.org/id/ENSP00000340740.4" } ] } }, { "isoform_ac": "O15350-8", "url": "", "sequence": { "sequence": "MLYVGDPARHLATAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMTIWRGLQDLKQGHDYSTAQQLLRSSNAATISIGGSGELQRQRVMEAVHFRVRHTITIPNRGGPGGGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH", "length": 587, "header": "sp|O15350-8|P73_HUMAN Isoform 8 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3733076, "end_pos": 3690906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378288.8", "url": "https://www.ensembl.org/id/ENST00000378288.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000367537.4", "url": "https://www.ensembl.org/id/ENSP00000367537.4" } ] } }, { "isoform_ac": "O15350-9", "url": "", "sequence": { "sequence": "MLYVGDPARHLATAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSTPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGAGVKKRRHGDEDTYYLQVRGRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGGMNKLPSVNQLVGQPPPHSSAATPNLGPVGPGMLNNHGHAVPANGEMSSSHSAQSMVSGSHCTPPPPYHADPSLVRTWGP", "length": 450, "header": "sp|O15350-9|P73_HUMAN Isoform 9 of Tumor protein p73 OS=Homo sapiens OX=9606 GN=TP73 PE=1 SV=1 CANONICAL=O15350-1" }, "locus": { "chromosome": "1", "start_pos": 3732759, "end_pos": 3690906, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000378285.5", "url": "https://www.ensembl.org/id/ENST00000378285.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000367534.1", "url": "https://www.ensembl.org/id/ENSP00000367534.1" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 14, "end_pos": 14, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "19218448", "url": "https://glygen.org/publication/PubMed/19218448" } ], "site_lbl": "Thr14" }, { "start_pos": 235, "end_pos": 235, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "22340593", "url": "https://glygen.org/publication/PubMed/22340593" } ], "site_lbl": "Ser235" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "P53350-1", "kinase_gene_name": "PLK1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "18174154", "url": "https://glygen.org/publication/PubMed/18174154" }, { "database": "PubMed", "id": "18418051", "url": "https://glygen.org/publication/PubMed/18418051" } ], "site_lbl": "Thr27" }, { "start_pos": 27, "end_pos": 27, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "Phosphothreonine; by PLK1", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "18174154", "url": "https://glygen.org/publication/PubMed/18174154" }, { "database": "PubMed", "id": "18418051", "url": "https://glygen.org/publication/PubMed/18418051" } ], "site_lbl": "Thr27" }, { "start_pos": 289, "end_pos": 289, "kinase_uniprot_canonical_ac": "Q05655-1", "kinase_gene_name": "PRKCD", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "12097319", "url": "https://glygen.org/publication/PubMed/12097319" } ], "site_lbl": "Ser289" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "P08631-1", "kinase_gene_name": "HCK", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "17535448", "url": "https://glygen.org/publication/PubMed/17535448" } ], "site_lbl": "Tyr28" }, { "start_pos": 28, "end_pos": 28, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by SRC and HCK", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "17535448", "url": "https://glygen.org/publication/PubMed/17535448" } ], "site_lbl": "Tyr28" }, { "start_pos": 426, "end_pos": 426, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "24874608", "url": "https://glygen.org/publication/PubMed/24874608" } ], "site_lbl": "Ser426" }, { "start_pos": 47, "end_pos": 47, "kinase_uniprot_canonical_ac": "O14757-1", "kinase_gene_name": "CHEK1", "residue": "Ser", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "14585975", "url": "https://glygen.org/publication/PubMed/14585975" } ], "site_lbl": "Ser47" }, { "start_pos": 47, "end_pos": 47, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "", "evidence": [ { "database": "phospho.ELM", "id": "O15350", "url": "http://phospho.elm.eu.org/byAccession/O15350.html" }, { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "14585975", "url": "https://glygen.org/publication/PubMed/14585975" } ], "site_lbl": "Ser47" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "P06493-1", "kinase_gene_name": "CDK1", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "12676926", "url": "https://glygen.org/publication/PubMed/12676926" } ], "site_lbl": "Thr86" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "P24941-1", "kinase_gene_name": "CDK2", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "12676926", "url": "https://glygen.org/publication/PubMed/12676926" }, { "database": "phospho.ELM", "id": "O15350", "url": "http://phospho.elm.eu.org/byAccession/O15350.html" } ], "site_lbl": "Thr86" }, { "start_pos": 86, "end_pos": 86, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Thr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "12676926", "url": "https://glygen.org/publication/PubMed/12676926" }, { "database": "PubMed", "id": "15985436", "url": "https://glygen.org/publication/PubMed/15985436" } ], "site_lbl": "Thr86" }, { "start_pos": 99, "end_pos": 99, "kinase_uniprot_canonical_ac": "P00519-1", "kinase_gene_name": "ABL1", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "10391251", "url": "https://glygen.org/publication/PubMed/10391251" } ], "site_lbl": "Tyr99" }, { "start_pos": 99, "end_pos": 99, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by ABL1", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "phospho.ELM", "id": "O15350", "url": "http://phospho.elm.eu.org/byAccession/O15350.html" }, { "database": "iPTMnet", "id": "O15350", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350" }, { "database": "PubMed", "id": "10391251", "url": "https://glygen.org/publication/PubMed/10391251" }, { "database": "PubMed", "id": "17535448", "url": "https://glygen.org/publication/PubMed/17535448" }, { "database": "PubMed", "id": "27228340", "url": "https://glygen.org/publication/PubMed/27228340" }, { "database": "PubMed", "id": "28257089", "url": "https://glygen.org/publication/PubMed/28257089" }, { "database": "PubMed", "id": "33375680", "url": "https://glygen.org/publication/PubMed/33375680" } ], "site_lbl": "Tyr99" } ], "glycation": [], "keywords": [], "publication": [ { "title": "The emerging p53 gene family.", "journal": "Journal of the National Cancer Institute", "date": "1999", "authors": "Kaelin WG Jr", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "reference": [ { "type": "PubMed", "id": "10203277", "url": "https://glygen.org/publication/PubMed/10203277" } ] }, { "title": "p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor.", "journal": "The Journal of biological chemistry", "date": "1999", "authors": "Budhram-Mahadeo V, Morris PJ, Smith MD, Midgley CA, Boxer LM, Latchman DS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6804759", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6804759" } ], "reference": [ { "type": "PubMed", "id": "10329733", "url": "https://glygen.org/publication/PubMed/10329733" } ] }, { "title": "Mutational analysis of p73 and p53 in human cancer cell lines.", "journal": "Oncogene", "date": "1999", "authors": "Yoshikawa H, Nagashima M, Khan M A, McMenamin M G, Hagiwara K, Harris C C", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "reference": [ { "type": "PubMed", "id": "10362363", "url": "https://glygen.org/publication/PubMed/10362363" } ] }, { "title": "Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants epsilon and zeta.", "journal": "Cell Death Differ.", "date": "1999", "authors": "De Laurenzi V D, Catani M V, Terrinoni A, Corazzari M, Melino G, Costanzo A, Levrero M, Knight R A", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "reference": [ { "type": "PubMed", "id": "10381648", "url": "https://glygen.org/publication/PubMed/10381648" } ] }, { "title": "p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.", "journal": "Nature", "date": "1999", "authors": "Yuan ZM, Shioya H, Ishiko T, Sun X, Gu J, Huang YY, Lu H, Kharbanda S, Weichselbaum R, Kufe D", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "iPTMnet", "id": "O15350-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15350-1" } ], "reference": [ { "type": "PubMed", "id": "10391251", "url": "https://glygen.org/publication/PubMed/10391251" } ] }, { "title": "Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.", "journal": "The EMBO journal", "date": "1999", "authors": "Hu Y, Benedict MA, Ding L, Nunez G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "10393175", "url": "https://glygen.org/publication/PubMed/10393175" } ] }, { "title": "Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain.", "journal": "EMBO J.", "date": "1999", "authors": "Chi S W, Ayed A, Arrowsmith C H", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "reference": [ { "type": "PubMed", "id": "10449409", "url": "https://glygen.org/publication/PubMed/10449409" } ] }, { "title": "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family.", "journal": "Genes & development", "date": "2000", "authors": "Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW, Jacks T", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "10733530", "url": "https://glygen.org/publication/PubMed/10733530" } ] }, { "title": "Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site.", "journal": "Oncogene", "date": "2000", "authors": "Takimoto R, El-Deiry WS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "10777207", "url": "https://glygen.org/publication/PubMed/10777207" } ] }, { "title": "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.", "journal": "Science (New York, N.Y.)", "date": "2000", "authors": "Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, Yamashita T, Tokino T, Taniguchi T, Tanaka N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "10807576", "url": "https://glygen.org/publication/PubMed/10807576" } ] }, { "title": "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Minty A, Dumont X, Kaghad M, Caput D", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "reference": [ { "type": "PubMed", "id": "10961991", "url": "https://glygen.org/publication/PubMed/10961991" } ] }, { "title": "Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis.", "journal": "Nature genetics", "date": "2000", "authors": "Lin Y, Ma W, Benchimol S", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "10973264", "url": "https://glygen.org/publication/PubMed/10973264" } ] }, { "title": "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.", "journal": "Cell", "date": "2000", "authors": "Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "11030628", "url": "https://glygen.org/publication/PubMed/11030628" } ] }, { "title": "Bcl-G, a novel pro-apoptotic member of the Bcl-2 family.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Guo B, Godzik A, Reed JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803205", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803205" } ], "reference": [ { "type": "PubMed", "id": "11054413", "url": "https://glygen.org/publication/PubMed/11054413" } ] }, { "title": "Direct transcriptional activation of human caspase-1 by tumor suppressor p53.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Gupta S, Radha V, Furukawa Y, Swarup G", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "11278253", "url": "https://glygen.org/publication/PubMed/11278253" } ] }, { "title": "Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene.", "journal": "Journal of cellular physiology", "date": "2001", "authors": "Guan B, Yue P, Clayman GL, Sun SY", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "11382926", "url": "https://glygen.org/publication/PubMed/11382926" } ] }, { "title": "Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803207", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803207" } ], "reference": [ { "type": "PubMed", "id": "11390368", "url": "https://glygen.org/publication/PubMed/11390368" } ] }, { "title": "PUMA, a novel proapoptotic gene, is induced by p53.", "journal": "Molecular cell", "date": "2001", "authors": "Nakano K, Vousden KH", "evidence": [ { "database": "Reactome", "id": "R-HSA-139915", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-139915" } ], "reference": [ { "type": "PubMed", "id": "11463392", "url": "https://glygen.org/publication/PubMed/11463392" } ] }, { "title": "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.", "journal": "Molecular cell", "date": "2001", "authors": "Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" 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"https://www.ncbi.nlm.nih.gov/protein/NP_001119712" } ], "reference": [ { "type": "PubMed", "id": "36451215", "url": "https://glygen.org/publication/PubMed/36451215" } ] }, { "title": "STAT3 promotes RNA polymerase III-directed transcription by controlling the miR-106a-5p/TP73 axis.", "journal": "eLife", "date": "2023-01-19", "authors": "Zhang Cheng, Zhao Shasha, Deng Huan, Zhang Shihua, Wang Juan, Song Xiaoye, Yu Deen, Zhang Yue, Deng Wensheng", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" } ], "reference": [ { "type": "PubMed", "id": "36656267", "url": "https://glygen.org/publication/PubMed/36656267" } ] }, { "title": "Clinical landscape of TP73 structural variants in ATL patients.", "journal": "Leukemia", "date": "2023-12", "authors": "Hiramatsu Hiroaki, Yokomori Rui, Shengyi Liu, Tanaka Norio, Mori Seiichi, Kiyotani Kazuma, Gotoh Osamu, Kusumoto Shigeru, Nakano Nobuaki, Suehiro Youko, Ito Asahi, Choi Ilseung, Ohtsuka Eiichi, Hidaka Michihiro, Nosaka Kisato, Yoshimitsu Makoto, Imaizumi Yoshitaka, Iida Shinsuke, Utsunomiya Atae, Noda Tetsuo, Nishikawa Hiroyoshi, Ueda Ryuzo, Sanda Takaomi, Ishida Takashi", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" } ], "reference": [ { "type": "PubMed", "id": "37864123", "url": "https://glygen.org/publication/PubMed/37864123" } ] }, { "title": "Loss of p73 Expression Contributes to Chronic Obstructive Pulmonary Disease.", "journal": "American journal of respiratory and critical care medicine", "date": "2024-01-15", "authors": "Richmond Bradley W, Marshall Clayton B, Blackburn Jessica B, Tufenkjian Tiffany S, Lehmann Brian D, Han Wei, Newcomb Dawn, Gutor Sergey S, Hunt Raphael P, Michell Danielle L, Vickers Kasey C, Polosukhin Vasiliy V, Blackwell Timothy S, Pietenpol Jennifer A", "evidence": [ { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" } ], "reference": [ { "type": "PubMed", "id": "37931077", "url": "https://glygen.org/publication/PubMed/37931077" } ] }, { "title": "Induction of the growth inhibitor IGF-binding protein 3 by p53.", "journal": "Nature", "date": "1995", "authors": "Buckbinder L, Talbott R, Velasco-Miguel S, Takenaka I, Faha B, Seizinger BR, Kley N", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "7566179", "url": "https://glygen.org/publication/PubMed/7566179" } ] }, { "title": "Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.", "journal": "Cell", "date": "1995", "authors": "Miyashita T, Reed JC", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803204", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204" } ], "reference": [ { "type": "PubMed", "id": "7834749", "url": 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], "reference": [ { "type": "PubMed", "id": "8242741", "url": "https://glygen.org/publication/PubMed/8242741" } ] }, { "title": "Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.", "journal": "Cell", "date": "1997", "authors": "Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" }, { "database": "RefSeq", "id": "NP_001119712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001119712" } ], "reference": [ { "type": "PubMed", "id": "9288759", "url": "https://glygen.org/publication/PubMed/9288759" } ] }, { "title": "KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.", "journal": "Nature genetics", "date": "1997", "authors": "Wu GS, Burns TF, McDonald ER 3rd, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G, el-Deiry WS", "evidence": [ { "database": "Reactome", "id": "R-HSA-6803211", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803211" } ], "reference": [ { "type": "PubMed", "id": "9326928", "url": "https://glygen.org/publication/PubMed/9326928" } ] }, { "title": "Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions.", "journal": "Genomics", "date": "1998", "authors": "Mai M, Huang H, Reed C, Qian C, Smith JS, Alderete B, Jenkins R, Smith DI, Liu W", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "reference": [ { "type": "PubMed", "id": "9721206", "url": "https://glygen.org/publication/PubMed/9721206" } ] }, { "title": "Two new p73 splice variants, gamma and delta, with different transcriptional activity.", "journal": "J. 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Med.", "date": "1998", "authors": "De Laurenzi V, Costanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchiarico-Petruzzelli M, Levrero M, Melino G", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "reference": [ { "type": "PubMed", "id": "9802988", "url": "https://glygen.org/publication/PubMed/9802988" } ] } ], "pathway": [ { "id": "hsa:7161", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7161", "resource": "KEGG Pathway" }, { "id": "R-HSA-139915", "name": "Activation of PUMA and translocation to mitochondria", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-139915", "resource": "Reactome", "description": "Activation of PUMA and translocation to mitochondria" }, { "id": "R-HSA-6803204", "name": "TP53 Regulates Transcription of Genes Involved in Cytochrome C Release", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-6803204", "resource": "Reactome", "description": "TP53 Regulates 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"url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" }, { "name": "Golgi apparatus", "id": "GO:0005794", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" }, { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" }, { "name": "cell junction", "id": "GO:0030054", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" }, { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" }, { "name": "chromatin", "id": "GO:0000785", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000785", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 23, "go_terms": [ { "name": "protein tetramerization", "id": "GO:0051262", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051262", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" }, { "name": "apoptotic process", "id": "GO:0006915", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } ], "pmid": "" }, { "name": "positive regulation of DNA-templated transcription", "id": "GO:0045893", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "evidence": [ { "database": "UniProtKB", "id": "O15350", "url": "https://www.uniprot.org/uniprot/O15350" } 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