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"annotation": "The results of transmission electron microscopy and immunoblotting to examine LC3-II levels further confirmed the ability of TM9SF1 to induce autophagy.", "evidence": [ { "database": "RefSeq", "id": "NP_001014842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014842" }, { "database": "PubMed", "id": "19029833", "url": "https://glygen.org/publication/PubMed/19029833" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs766298745", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766298745" }, { "id": "rs766298745", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs766298745" }, { "id": "rs766298745", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs766298745#frequency_tab" }, { "id": "rs766298745", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs766298745" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 178, "end_pos": 178, 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"sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606, "header": "sp|O15321-1|TM9S1_HUMAN Isoform 1 of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=2 CANONICAL=O15321-1" }, "isoforms": [ { "isoform_ac": "E9PJC4-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSE", "length": 210, "header": "tr|E9PJC4-1|TM9S1_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=1 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24192985, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000528010.1", "url": "https://www.ensembl.org/id/ENST00000528010.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000433792.1", "url": "https://www.ensembl.org/id/ENSP00000433792.1" } ] } }, { "isoform_ac": "E9PJM1-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSGSASHNHPAASDGLAAGGLSPHCHWRHLWEEQRQPL", "length": 420, "header": "tr|E9PJM1-1|E9PJM1_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member OS=Homo sapiens OX=9606 GN=TM9SF1 PE=1 SV=1 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24190485, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000529332.5", "url": "https://www.ensembl.org/id/ENST00000529332.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000431747.1", "url": "https://www.ensembl.org/id/ENSP00000431747.1" } ] } }, { "isoform_ac": "E9PL78-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRF", "length": 300, "header": "tr|E9PL78-1|E9PL78_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member OS=Homo sapiens OX=9606 GN=TM9SF1 PE=1 SV=8 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24192715, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000528895.5", "url": "https://www.ensembl.org/id/ENST00000528895.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000431447.1", "url": "https://www.ensembl.org/id/ENSP00000431447.1" } ] } }, { "isoform_ac": "E9PMQ9-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPCAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 589, "header": "tr|E9PMQ9-1|E9PMQ9_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member OS=Homo sapiens OX=9606 GN=TM9SF1 PE=1 SV=1 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24189418, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000528669.5", "url": "https://www.ensembl.org/id/ENST00000528669.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000432997.1", "url": "https://www.ensembl.org/id/ENSP00000432997.1" } ] } }, { "isoform_ac": "E9PNW2-1", "url": "", "sequence": { "sequence": "MAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIH", "length": 207, "header": "tr|E9PNW2-1|TM9S1_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=8 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24194758, "end_pos": 24192733, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000530563.1", "url": "https://www.ensembl.org/id/ENST00000530563.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000437127.1", "url": "https://www.ensembl.org/id/ENSP00000437127.1" } ] } }, { "isoform_ac": "E9PP24-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTALVQVYCHPHDCWRLPAFQCHLCGAVLHLCHSMGSGAVHFVRHPLLCLRHPAECGGLHLHCTHLLPVVWGGLPLVVAICAECWLHRPLHLPLLSFLLCPALQHVWGSTD", "length": 133, "header": "tr|E9PP24-1|E9PP24_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=4 SV=1 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24189539, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000532632.1", "url": "https://www.ensembl.org/id/ENST00000532632.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000436486.1", "url": "https://www.ensembl.org/id/ENSP00000436486.1" } ] } }, { "isoform_ac": "E9PQY7-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINS", "length": 242, "header": "tr|E9PQY7-1|TM9S1_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=1 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24192889, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000525592.1", "url": "https://www.ensembl.org/id/ENST00000525592.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000432435.1", "url": "https://www.ensembl.org/id/ENSP00000432435.1" } ] } }, { "isoform_ac": "E9PS99-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVIL", "length": 257, "header": "tr|E9PS99-1|E9PS99_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member OS=Homo sapiens OX=9606 GN=TM9SF1 PE=1 SV=1 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24192844, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000530468.5", "url": "https://www.ensembl.org/id/ENST00000530468.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000435857.1", "url": "https://www.ensembl.org/id/ENSP00000435857.1" } ] } }, { "isoform_ac": "G3V1B9-1", "url": "", "sequence": { "sequence": "MAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 519, "header": "tr|G3V1B9-1|TM9S1_HUMAN Computationally mapped isoform of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=1 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24194758, "end_pos": 24189418, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000524835.5", "url": "https://www.ensembl.org/id/ENST00000524835.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000434387.1", "url": "https://www.ensembl.org/id/ENSP00000434387.1" } ] } }, { "isoform_ac": "O15321-1", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606, "header": "sp|O15321-1|TM9S1_HUMAN Isoform 1 of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=2 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24189418, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000261789.9", "url": "https://www.ensembl.org/id/ENST00000261789.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000261789.4", "url": "https://www.ensembl.org/id/ENSP00000261789.4" } ] } }, { "isoform_ac": "O15321-2", "url": "", "sequence": { "sequence": "MTVVGNPRSWSCQWLPILILLLGTGHGPGVEGVTHYKAGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRPDEFLGLTHTYSVRWSETSVERRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETTSAGSGDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFRYPPFIPWLLLSGS", "length": 489, "header": "sp|O15321-2|TM9S1_HUMAN Isoform 2 of Transmembrane 9 superfamily member 1 OS=Homo sapiens OX=9606 GN=TM9SF1 PE=2 SV=2 CANONICAL=O15321-1" }, "locus": { "chromosome": "14", "start_pos": 24195019, "end_pos": 24190340, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000396854.8", "url": "https://www.ensembl.org/id/ENST00000396854.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000380063.4", "url": "https://www.ensembl.org/id/ENSP00000380063.4" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G23294PN", "type": "N-linked", "subtype": "", "site_category": "reported_with_glycan", "site_seq": "N", "relation": "attached", "comment": "", "start_pos": 178, "start_aa": "Asn", "end_pos": 178, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn178", "evidence": [ { "id": "1841", "database": "GlyConnect", "url": "https://glyconnect.expasy.org/browser/proteins/1841" }, { "id": "29741879", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "reported", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 178, "start_aa": "Asn", "end_pos": 178, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn178", "evidence": [ { "id": "O15321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15321#ptm_processing" }, { "id": "24190977", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/24190977" }, { "id": "GLY_000143", "database": "GlyGen", "url": "https://data.glygen.org/GLY_000143" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 401, "start_aa": "Asn", "end_pos": 401, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn401", "evidence": [ { "id": "O15321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15321#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 559, "start_aa": "Asn", "end_pos": 559, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn559", "evidence": [ { "id": "O15321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15321#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "High-throughput functional screening for autophagy-related genes and identification of TM9SF1 as an autophagosome-inducing gene.", "journal": "Autophagy", "date": "2009", "authors": "He P, Peng Z, Luo Y, Wang L, Yu P, Deng W, An Y, Shi T, Ma D", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" }, { "database": "RefSeq", "id": "NP_001014842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014842" } ], "reference": [ { "type": "PubMed", "id": "19029833", "url": "https://glygen.org/publication/PubMed/19029833" } ] }, { "title": "N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes.", "journal": "Molecular & cellular proteomics : MCP", "date": "2014", "authors": "Deeb SJ, Cox J, Schmidt-Supprian M, Mann M", "evidence": [ { "database": "GlyGen", "id": "GLY_000143", "url": "https://data.glygen.org/GLY_000143" } ], "reference": [ { "type": "PubMed", "id": "24190977", "url": "https://glygen.org/publication/PubMed/24190977" } ] }, { "title": "Reanalysis of Global Proteomic and Phosphoproteomic Data Identified a Large Number of Glycopeptides.", "journal": "Analytical chemistry", "date": "2018", "authors": "Hu Y, Shah P, Clark DJ, Ao M, Zhang H", "evidence": [ { "database": "GlyConnect", "id": "1841", "url": "https://glyconnect.expasy.org/browser/proteins/1841" } ], "reference": [ { "type": "PubMed", "id": "29741879", "url": "https://glygen.org/publication/PubMed/29741879" } ] }, { "title": "Cloning of a human multispanning membrane protein cDNA: evidence for a new protein family.", "journal": "Gene", "date": "1997", "authors": "Chluba-de Tapia J, de Tapia M, Jaggin V, Eberle AN", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" } ], "reference": [ { "type": "PubMed", "id": "9332367", "url": "https://glygen.org/publication/PubMed/9332367" } ] } ], "pathway": [ { "id": "hsa:10548", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10548", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "Q66HF2-1", "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "Tm9sf1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MTVLGHPRSWSCHCLPVLILLLGIGHGPRVEGVTHYKPGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRSDELLGLTHTYSVRWSETSVEHRSDRRRADDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKIIHTDVFRFPPCRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTTSLFSVPFFLTWSVVNSVHWANGSTQALPVTTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPCAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 589 }, "evidence": [ { "id": "45925576", "url": "http://www.informatics.jax.org/homology/45925576", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q9DBU0-1", "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "Tm9sf1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MTVLGYPRSWSCHCLPVLILLLGIGHGPWVEGVTHYKPGDPVILYVNKVGPYHNPQETYHYYQLPVCCPEKIRHKSLSLGEVLDGDRMAESLYEIRFRENVEKRILCHMQLSSAQVEQLRQAIEELYYFEFVVDDLPIRGFVGYMEESGFLPHSHKIGLWTHLDFHLEFHGDRIIFANVSVRDVKPHSLDGLRSDELLGLTHTYSVRWSETSVEHRSDRRRGDDGGFFPRTLEIHWLSIINSMVLVFLLVGFVAVILMRVLRNDLARYNLDEETSSGGSSDDFDQGDNGWKIIHTDVFRFPPYRGLLCAVLGVGAQFLALGTGIIVMALLGMFNVHRHGAINSAAILLYALTCCISGYVSSHFYRQIGGERWVWNIILTSSLFSVPFFLTWSVVNSVHWANGSTQALPATTILLLLTVWLLVGFPLTVIGGIFGKNNASPFDAPCRTKNIAREIPPQPWYKSTVIHMTVGGFLPFSAISVELYYIFATVWGREQYTLYGILFFVFAILLSVGACISIALTYFQLSGEDYRWWWRSVLSVGSTGLFIFLYSVFYYARRSNMSGAVQTVEFFGYSLLTGYVFFLMLGTISFFSSLKFIRYIYVNLKMD", "length": 606 }, "evidence": [ { "id": "45925576", "url": "http://www.informatics.jax.org/homology/45925576", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "autophagosome membrane", "id": "GO:0000421", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000421", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" } ], "pmid": "" }, { "name": "lysosomal membrane", "id": "GO:0005765", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005765", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" } ], "pmid": "" }, { "name": "cytoplasmic vesicle", "id": "GO:0031410", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 2, "go_terms": [ { "name": "autophagy", "id": "GO:0006914", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006914", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" } ], "pmid": "" }, { "name": "protein localization to membrane", "id": "GO:0072657", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072657", "evidence": [ { "database": "UniProtKB", "id": "O15321", "url": "https://www.uniprot.org/uniprot/O15321" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 178, "end_pos": 180, "annotation": "n_glycosylation_sequon" }, { "start_pos": 401, "end_pos": 403, "annotation": "n_glycosylation_sequon" }, { "start_pos": 437, "end_pos": 439, "annotation": "n_glycosylation_sequon" }, { "start_pos": 559, "end_pos": 561, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [ 178, 401, 559 ], "o_linked_sites": [], "snv_sites": [ 178, 240, 401, 403, 438, 451, 559, 561 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 178, "end_pos": 180 }, { "start_pos": 401, "end_pos": 403 }, { "start_pos": 437, "end_pos": 439 }, { "start_pos": 559, "end_pos": 561 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 4 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 1 }, { "field": "n_linked_glycan_sites", "count": 1 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 9 }, { "field": "total_sites", "count": 8 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 7 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 4 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }