{ "uniprot_canonical_ac": "O15304-1", "uniprot_ac": "O15304", "uniprot_id": "SIVA_HUMAN", "mass": { "chemical_mass": 18695.0, "monoisotopic_mass": 18695.0 }, "refseq": { "ac": "NP_006418", "name": "apoptosis regulatory protein Siva isoform 1", "summary": "This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" }, "gene_names": [ { "name": "SIVA1", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15304", "id": "O15304" }, { "name": "CD27BP; SIVA; Siva-1; Siva-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418", "id": "NP_006418" }, { "name": "SIVA1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418", "id": "NP_006418" }, { "name": "SIVA", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15304", "id": "O15304" } ], "protein_names": [ { "name": "Apoptosis regulatory protein Siva", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15304" }, { "name": "CD27-binding (Siva) protein; apoptosis regulatory protein Siva", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418", "id": "NP_006418" }, { "name": "CD27-binding protein", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15304" }, { "name": "CD27BP", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15304" }, { "name": "apoptosis regulatory protein Siva isoform 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418", "id": "NP_006418" } ], "function": [ { "annotation": "Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304#function" }, { "database": "PubMed", "id": "12011449", "url": "https://glygen.org/publication/PubMed/12011449" }, { "database": "PubMed", "id": "15034012", "url": "https://glygen.org/publication/PubMed/15034012" }, { "database": "PubMed", "id": "16491128", "url": "https://glygen.org/publication/PubMed/16491128" }, { "database": "PubMed", "id": "14739602", "url": "https://glygen.org/publication/PubMed/14739602" }, { "database": "PubMed", "id": "15958577", "url": "https://glygen.org/publication/PubMed/15958577" }, { "database": "UniProtKB", "id": "G3V3U1", "url": "https://www.uniprot.org/uniprot/G3V3U1#function" }, { "database": "UniProtKB", "id": "PIRNR038096", "url": "https://www.uniprot.org/uniprot/PIRNR038096#function" }, { "database": "UniProtKB", "id": "B4DTY2", "url": "https://www.uniprot.org/uniprot/B4DTY2#function" } ] }, { "annotation": "Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" }, { "database": "PubMed", "id": "37303491", "url": "https://glygen.org/publication/PubMed/37303491" } ] }, { "annotation": "N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis.", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" }, { "database": "PubMed", "id": "36307991", "url": "https://glygen.org/publication/PubMed/36307991" } ] }, { "annotation": "PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1.", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" }, { "database": "PubMed", "id": "32329870", "url": "https://glygen.org/publication/PubMed/32329870" } ] }, { "annotation": "SIVA1 enhances SSBP3 ubiquitination and promotes SSBP3 protein turnover", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" }, { "database": "PubMed", "id": "30363057", "url": "https://glygen.org/publication/PubMed/30363057" } ] }, { "annotation": "Siva1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NFkappaB pathway.", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" }, { "database": "PubMed", "id": "32626967", "url": "https://glygen.org/publication/PubMed/32626967" } ] }, { "annotation": "This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018].", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 34, "end_pos": 34, "sequence_org": "Y", "sequence_mut": "F", "comment": "Abolishes phosphorylation and apoptotic activity.", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" }, { "database": "PubMed", "id": "11278261", "url": "https://glygen.org/publication/PubMed/11278261" } ] }, { "start_pos": 53, "end_pos": 53, "sequence_org": "Y", "sequence_mut": "F", "comment": "No effect on phosphorylation or apoptotic activity.", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" }, { "database": "PubMed", "id": "11278261", "url": "https://glygen.org/publication/PubMed/11278261" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "86.33", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "81.95", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "87.3", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "85.66", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "97.53", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "82.3", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "81.5", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "90.69", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "95.28", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "75.55", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "88.88", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "96.36", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "95.44", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000184990", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000184990" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O15304", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15304" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", 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"resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O15304", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15304" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": 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results_in malignant growth located_in the urinary bladder." }, "synonyms": [ { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "bladder cancer", "description": "" }, { "id": "DOID:11054", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:11054", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "urinary bladder cancer", "description": "A primary or metastatic malignant neoplasm involving the bladder." }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "tumour of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the 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"database": "Ensembl Peptide", "id": "ENSP00000485991.1", "url": "https://www.ensembl.org/id/ENSP00000485991.1" } ] } }, { "isoform_ac": "G3V3U1-1", "url": "", "sequence": { "sequence": "MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVEPALCWKEHDVGM", "length": 169, "header": "tr|G3V3U1-1|G3V3U1_HUMAN Computationally mapped isoform of Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=1 CANONICAL=O15304-1" }, "locus": { "chromosome": "14", "start_pos": 104766826, "end_pos": 104753202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000553819.5", "url": "https://www.ensembl.org/id/ENST00000553819.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000451427.1", "url": "https://www.ensembl.org/id/ENSP00000451427.1" } ] } }, { "isoform_ac": "G3V439-1", "url": "", "sequence": { "sequence": "MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVEGYSPGGWEWTVW", "length": 169, "header": "tr|G3V439-1|G3V439_HUMAN Computationally mapped isoform of SIVA1 apoptosis inducing factor OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=1 CANONICAL=O15304-1" }, "locus": { "chromosome": "14", "start_pos": 104757311, "end_pos": 104753202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000553810.5", "url": "https://www.ensembl.org/id/ENST00000553810.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000451570.1", "url": "https://www.ensembl.org/id/ENSP00000451570.1" } ] } }, { "isoform_ac": "H0YJN1-1", "url": "", "sequence": { "sequence": "MLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET", "length": 90, "header": "tr|H0YJN1-1|H0YJN1_HUMAN Computationally mapped isoform of SIVA1 apoptosis inducing factor OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2 CANONICAL=O15304-1" }, "locus": { "chromosome": "14", "start_pos": 104759482, "end_pos": 104755767, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000556195.2", "url": "https://www.ensembl.org/id/ENST00000556195.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000451823.2", "url": "https://www.ensembl.org/id/ENSP00000451823.2" } ] } }, { "isoform_ac": "O15304-1", "url": "", "sequence": { "sequence": "MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFEKTKRLLFLGAQAYLDHVWDEGCAVVHLPESPKPGPTGAPRAARGQMLIGPDGRLIRSLGQASEADPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET", "length": 175, "header": "sp|O15304-1|SIVA_HUMAN Isoform 1 of Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2 CANONICAL=O15304-1" }, "locus": { "chromosome": "14", "start_pos": 104759482, "end_pos": 104753202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000329967.11", "url": "https://www.ensembl.org/id/ENST00000329967.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000329213.6", "url": "https://www.ensembl.org/id/ENSP00000329213.6" } ] } }, { "isoform_ac": "O15304-2", "url": "", "sequence": { "sequence": "MPKRSCPFADVAPLQLKVRVSQRELSRGVCAERYSQEVFDPSGVASIACSSCVRAVDGKAVCGQCERALCGQCVRTCWGCGSVACTLCGLVDCSDMYEKVLCTSCAMFET", "length": 110, "header": "sp|O15304-2|SIVA_HUMAN Isoform 2 of Apoptosis regulatory protein Siva OS=Homo sapiens OX=9606 GN=SIVA1 PE=1 SV=2 CANONICAL=O15304-1" }, "locus": { "chromosome": "14", "start_pos": 104759482, "end_pos": 104753202, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000347067.9", "url": "https://www.ensembl.org/id/ENST00000347067.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000329447.6", "url": "https://www.ensembl.org/id/ENSP00000329447.6" } ] } } ], "glycosylation": [], "phosphorylation": [ { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "P42684-1", "kinase_gene_name": "ABL2", "residue": "Tyr", "comment": "", "evidence": [ { "database": "iPTMnet", "id": "O15304", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15304" }, { "database": "PubMed", "id": "11278261", "url": "https://glygen.org/publication/PubMed/11278261" }, { "database": "phospho.ELM", "id": "O15304", "url": "http://phospho.elm.eu.org/byAccession/O15304.html" } ], "site_lbl": "Tyr34" }, { "start_pos": 34, "end_pos": 34, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by ABL2", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" }, { "database": "UniProtKB", "id": "B4DTY2", "url": "https://www.uniprot.org/uniprot/B4DTY2" }, { "database": "UniProtKB", "id": "G3V439", "url": "https://www.uniprot.org/uniprot/G3V439" }, { "database": "UniProtKB", "id": "G3V3U1", "url": "https://www.uniprot.org/uniprot/G3V3U1" }, { "database": "iPTMnet", "id": "O15304", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15304" }, { "database": "PubMed", "id": "11278261", "url": "https://glygen.org/publication/PubMed/11278261" } ], "site_lbl": "Tyr34" }, { "start_pos": 70, "end_pos": 70, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" }, { "database": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" }, { "database": "iPTMnet", "id": "O15304", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15304" } ], "site_lbl": "Ser70" } ], "glycation": [], "keywords": [], "publication": [ { "title": "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva.", "journal": "J. Virol.", "date": "2000", "authors": "Henke A, Launhardt H, Klement K, Stelzner A, Zell R, Munder T", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "10756043", "url": "https://glygen.org/publication/PubMed/10756043" } ] }, { "title": "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Cao C, Ren X, Kharbanda S, Koleske AJ, Prasad KV, Kufe D", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" }, { "database": "iPTMnet", "id": "O15304", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15304" } ], "reference": [ { "type": "PubMed", "id": "11278261", "url": "https://glygen.org/publication/PubMed/11278261" } ] }, { "title": "The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva.", "journal": "Virology", "date": "2001", "authors": "Henke A, Nestler M, Strunze S, Saluz HP, Hortschansky P, Menzel B, Martin U, Zell R, Stelzner A, Munder T", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "11601913", "url": "https://glygen.org/publication/PubMed/11601913" } ] }, { "title": "Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2002-05-14", "authors": "Xue Li, Chu Fei, Cheng Yuan, Sun Xiangjie, Borthakur Alip, Ramarao Manjunath, Pandey Pramod, Wu Mei, Schlossman Stuart F, Prasad Kanteti V S", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "12011449", "url": "https://glygen.org/publication/PubMed/12011449" } ] }, { "title": "The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis.", "journal": "Apoptosis : an international journal on programmed cell death", "date": "2004-01", "authors": "Chu F, Borthakur A, Sun X, Barkinge J, Gudi R, Hawkins S, Prasad K V S", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "14739602", "url": "https://glygen.org/publication/PubMed/14739602" } ] }, { "title": "Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "date": "2004-04-01", "authors": "Py B\u00e9n\u00e9dicte, Slomianny Christian, Auberger Patrick, Petit Patrice X, Benichou Serge", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "15034012", "url": "https://glygen.org/publication/PubMed/15034012" } ] }, { "title": "Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2.", "journal": "Cancer research", "date": "2005-06-15", "authors": "Chu Fei, Barkinge John, Hawkins Sarah, Gudi Radhika, Salgia Ravi, Kanteti Prasad V S", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "15958577", "url": "https://glygen.org/publication/PubMed/15958577" } ] }, { "title": "Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD).", "journal": "Oncogene", "date": "2006-06-08", "authors": "Gudi R, Barkinge J, Hawkins S, Chu F, Manicassamy S, Sun Z, Duke-Cohan J S, Prasad K V S", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "16491128", "url": "https://glygen.org/publication/PubMed/16491128" } ] }, { "title": "The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22.", "journal": "Mol. Cell. Biochem.", "date": "2006", "authors": "Nestler Matthias, Martin Ulrike, Hortschansky Peter, Saluz Hans-Peter, Henke Andreas, Munder Thomas", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "16683188", "url": "https://glygen.org/publication/PubMed/16683188" } ] }, { "title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.", "journal": "Journal of proteomics", "date": "2014", "authors": "Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" }, { "database": "iPTMnet", "id": "O15304", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15304" } ], "reference": [ { "type": "PubMed", "id": "24275569", "url": "https://glygen.org/publication/PubMed/24275569" } ] }, { "title": "[SIVA1 Regulates the Stability of Single-Stranded DNA-Binding Protein 3 Isoforms].", "journal": "Molekuliarnaia biologiia", "date": "2018", "authors": "Yin Z, Zhang K, Peng X, Jiang Z, Yuan W, Wang Y, Li Y, Ye X, Dong Y, Wan Y, Ni B, Zhu P, Fan X, Wu X, Mo X", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" } ], "reference": [ { "type": "PubMed", "id": "30363057", "url": "https://glygen.org/publication/PubMed/30363057" } ] }, { "title": "PM2.5 exposure induces alveolar epithelial cell apoptosis and causes emphysema through p53/Siva-1.", "journal": "European review for medical and pharmacological sciences", "date": "2020", "authors": "Xu F, Xu A, Guo Y, Bai Q, Wu X, Ji SP, Xia RX", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" } ], "reference": [ { "type": "PubMed", "id": "32329870", "url": "https://glygen.org/publication/PubMed/32329870" } ] }, { "title": "Siva1 regulates multidrug resistance of gastric cancer by targeting MDR1 and MRP1 via the NFkappaB pathway.", "journal": "Molecular medicine reports", "date": "2020", "authors": "Kong FB, Deng QM, Deng HQ, Dong CC, Li L, He CG, Wang XT, Xu S, Mai W", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" } ], "reference": [ { "type": "PubMed", "id": "32626967", "url": "https://glygen.org/publication/PubMed/32626967" } ] }, { "title": "N6-methyladenosine demethylase FTO enhances chemo-resistance in colorectal cancer through SIVA1-mediated apoptosis.", "journal": "Molecular therapy : the journal of the American Society of Gene Therapy", "date": "2022-10-28", "authors": "Lin Ziyou, Wan Arabella H, Sun Lei, Liang Heng, Niu Yi, Deng Yuan, Yan Shijia, Wang Qiao-Ping, Bu Xianzhang, Zhang Xiaolei, Hu Kunhua, Wan Guohui, He Weiling", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" } ], "reference": [ { "type": "PubMed", "id": "36307991", "url": "https://glygen.org/publication/PubMed/36307991" } ] }, { "title": "Inhibition of apoptosis-regulatory protein Siva-1 reverses multidrug resistance in gastric cancer by targeting PCBP1.", "journal": "Oncology research", "date": "2022", "authors": "Kong Fanbiao, Wu Kun, Pang Liming, Huang Yuliang, Li Lei, Xu Jing, Li Feitong, Qing Yan, Wang Zhongyu, Huang Xiurong, Xu Sheng, Zhong Xiaogang, Zhu Zhou, Wang Xiaotong, Yang Jianrong", "evidence": [ { "database": "RefSeq", "id": "NP_006418", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006418" } ], "reference": [ { "type": "PubMed", "id": "37303491", "url": "https://glygen.org/publication/PubMed/37303491" } ] }, { "title": "CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1997", "authors": "Prasad K V, Ao Z, Yoon Y, Wu M X, Rizk M, Jacquot S, Schlossman S F", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "reference": [ { "type": "PubMed", "id": "9177220", "url": "https://glygen.org/publication/PubMed/9177220" } ] } ], "pathway": [ { "id": "hsa:10572", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:10572", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "O54926-1", "protein_name": "Apoptosis regulatory protein Siva", "gene_name": "Siva1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPKRSCPFADAAPLQLKVHVGLKELSHGVFAERYSREVFERTKQLLFQGARAYRDHISSEDCSVNHLQESLKSGVVGAPQPARGQMLIGPDGRLTRCQAQASEGGLPRTAPIACSSCMRSVDGKAVCSQCERALCGQCVYTCWGCGALACVLCGLADYADDGEKTLCTSCAMFEA", "length": 175 }, "evidence": [ { "id": "45929768", "url": "http://www.informatics.jax.org/homology/45929768", "database": "MGI" }, { "id": "O15304", "url": "https://omabrowser.org/oma/group/O15304/", "database": "OMA" } ], "common_name": "Mouse" }, { "uniprot_canonical_ac": "P59692-1", "protein_name": "Apoptosis regulatory protein Siva", "gene_name": "Siva1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPKRSCPFTDAAPLQLKVHVSPRELSHGVFAERYSREVFERTKQLLFQGAQAYRDHIWGEGCSINHLPEPLKPGLVGAPQAARGQMLIGPDGRLTRCQAQASEAGLPGAAPIACSSCVRSVDGKAVCSQCERALCGQCVYTCWGCGALACVLCGLADYADDDDGEKTLCTSCAMFEA", "length": 177 }, "evidence": [ { "id": "O15304", "url": "https://omabrowser.org/oma/group/O15304/", "database": "OMA" } ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "nucleoplasm", "id": "GO:0005654", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "pmid": "" }, { "name": "cytoplasm", "id": "GO:0005737", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "pmid": "" }, { "name": "mitochondrion", "id": "GO:0005739", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 6, "go_terms": [ { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O15304", "url": "https://www.uniprot.org/uniprot/O15304" } ], "pmid": "" }, { "name": "zinc ion binding", "id": "GO:0008270", "url": 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