{ "uniprot_canonical_ac": "O15297-1", "uniprot_ac": "O15297", "uniprot_id": "PPM1D_HUMAN", "mass": { "chemical_mass": 66675.0, "monoisotopic_mass": 66675.0 }, "refseq": { "ac": "NP_003611", "name": "protein phosphatase 1D", "summary": "The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" }, "gene_names": [ { "name": "PPM1D", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15297", "id": "O15297" }, { "name": "IDDGIP; JDVS; PP2C-DELTA; WIP1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611", "id": "NP_003611" }, { "name": "PPM1D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611", "id": "NP_003611" }, { "name": "WIP1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15297", "id": "O15297" } ], "protein_names": [ { "name": "Protein phosphatase 1D", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15297" }, { "name": "3.1.3.16", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15297" }, { "name": "PP2C-delta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15297" }, { "name": "Protein phosphatase 2C isoform delta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15297" }, { "name": "Protein phosphatase magnesium-dependent 1 delta", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15297" }, { "name": "p53-induced protein phosphatase 1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15297" }, { "name": "protein phosphatase 1D", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611", "id": "NP_003611" }, { "name": "wild-type p53-induced phosphatase 1; protein phosphatase Wip1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611", "id": "NP_003611" } ], "function": [ { "annotation": "A Case Study on PPM1D and 9 Other Shared Germline Alterations in a Family. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" }, { "database": "PubMed", "id": "37378944", "url": "https://glygen.org/publication/PubMed/37378944" } ] }, { "annotation": "Involved in the negative regulation of p53 expression (PubMed:23242139). Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins (PubMed:15870257, PubMed:16311512). Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297#function" }, { "database": "PubMed", "id": "15870257", "url": "https://glygen.org/publication/PubMed/15870257" }, { "database": "PubMed", "id": "21283629", "url": "https://glygen.org/publication/PubMed/21283629" }, { "database": "PubMed", "id": "16311512", "url": "https://glygen.org/publication/PubMed/16311512" }, { "database": "PubMed", "id": "23242139", "url": "https://glygen.org/publication/PubMed/23242139" }, { "database": "UniProtKB", "id": "Q9QZ67", "url": "https://www.uniprot.org/uniprot/Q9QZ67#function" } ] }, { "annotation": "Jansen-de Vries syndrome: Expansion of the PPM1D clinical and phenotypic spectrum in 34 families.", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" }, { "database": "PubMed", "id": "37183572", "url": "https://glygen.org/publication/PubMed/37183572" } ] }, { "annotation": "Low-Frequency PPM1D Gene Mutations Affect Treatment Response to CD19-Targeted CAR T-Cell Therapy in Large B-Cell Lymphoma. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" }, { "database": "PubMed", "id": "38132396", "url": "https://glygen.org/publication/PubMed/38132396" } ] }, { "annotation": "PPM1D activity promotes the replication stress caused by cyclin E1 overexpression.", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" }, { "database": "PubMed", "id": "37067201", "url": "https://glygen.org/publication/PubMed/37067201" } ] }, { "annotation": "PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" }, { "database": "PubMed", "id": "37595362", "url": "https://glygen.org/publication/PubMed/37595362" } ] }, { "annotation": "The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" } ] } ], "disease": [ { "disease_id": "DOID:1612", "recommended_name": { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast cancer", "description": "A thoracic cancer that originates in the mammary gland." }, "synonyms": [ { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "breast tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ], "evidence": [ { "id": "114480", "database": "MIM", "url": "https://www.omim.org/entry/114480" } ] }, { "disease_id": "DOID:2394", "recommended_name": { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian cancer", "description": "A female reproductive organ cancer that is located_in the ovary." }, "synonyms": [ { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant Ovarian tumor", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "malignant tumour of ovary", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovarian neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "ovary neoplasm", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "primary ovarian cancer", "description": "" }, { "id": "DOID:2394", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2394", "name": "tumor of the Ovary", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "OVCAS1", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to", "description": "" }, { "id": "MONDO:0011931", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011931", "name": "ovarian cancer, susceptibility to, 1", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "A primary or metastatic malignant neoplasm involving the ovary. Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors. Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas." }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "cancer of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant neoplasm of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovarian tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant ovary neoplasm", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumor of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "malignant tumour of the ovary", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, somatic", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumor", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian malignant tumour", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovary cancer", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "ovarian cancer, epithelial", "description": "" }, { "id": "MONDO:0008170", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0008170", "name": "primary ovarian cancer", "description": "" }, { "id": "MIM:167000", "resource": "MIM", "url": "https://www.omim.org/entry/167000", "name": "Ovarian cancer", "description": "Ovarian cancer" } ], "evidence": [ { "id": "167000", "database": "MIM", "url": "https://www.omim.org/entry/167000" } ] }, { "disease_id": "MONDO:0044318", "recommended_name": { "id": "MONDO:0044318", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0044318", "name": "intellectual developmental disorder with gastrointestinal difficulties and high pain threshold", "description": "IDDGIP is an autosomal dominant syndromic neurodevelopmental disorder characterized by delayed psychomotor development, intellectual disability with speech delay, and behavioral abnormalities. Most patients have variable additional features, including feeding and gastrointestinal difficulties, high pain threshold and/or hypersensitivity to sound, and dysmorphic features, including mild facial abnormalities, strabismus, and small hands and feet (summary by {1:Jansen et al., 2017})." }, "synonyms": [ { "id": "MONDO:0044318", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0044318", "name": "Jansen de Vries syndrome", "description": "" }, { "id": "MONDO:0044318", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0044318", "name": "intellectual developmental disorder with gastrointestinal difficulties and high pain threshold", "description": "" }, { "id": "MONDO:0044318", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0044318", "name": "IDDGIP", "description": "" }, { "id": "MIM:617450", "resource": "MIM", "url": "https://www.omim.org/entry/617450", "name": "Jansen-de Vries syndrome", "description": "Jansen-de Vries syndrome" } ], "evidence": [ { "id": "617450", "database": "MIM", "url": "https://www.omim.org/entry/617450" } ] } ], "snv": [ { "evidence": [ { "id": "rs142406693", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142406693" }, { "id": "rs142406693", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs142406693" }, { "id": "rs142406693", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs142406693" }, { "id": "rs142406693", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs142406693#frequency_tab" }, { "id": "rs142406693", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs142406693" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 479, "end_pos": 479, "sequence_org": "A", "sequence_mut": "T", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NCA->NCT).", "chr_id": "17", "chr_pos": "60663169", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "0.002596", "site_lbl": "A479", "keywords": [ "ebi", "germline" ] } ], "mutagenesis": [ { "start_pos": 314, "end_pos": 314, "sequence_org": "D", "sequence_mut": "A", "comment": "Abrogates phosphatase activity.", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" }, { "database": "PubMed", "id": "15870257", "url": "https://glygen.org/publication/PubMed/15870257" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "70.86", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "77.79", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "68.62", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "61.83", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "80.83", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "82.47", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "57.55", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "79.91", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000170836", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000170836" } ] }, { "tissue": { "name": "Thyroid gland", 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"https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", 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cancer that is located_in the colon and/or located_in the rectum." }, "synonyms": [ { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma." }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "cancer of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, advanced, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": 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somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectum cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectal tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant colorectum neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": 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}, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": 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"Protein Classification" ] }, { "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "20629", "url": "https://www.rhea-db.org/rhea/20629", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "47004", "url": "https://www.rhea-db.org/rhea/47004", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A0S2Z4W0", "url": "https://www.uniprot.org/uniprot/A0A0S2Z4W0", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A0S2Z4W0-1", "url": "https://www.uniprot.org/uniprot/A0A0S2Z4W0-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KNX5", "url": "https://www.uniprot.org/uniprot/A0A8I5KNX5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KNX5-1", "url": "https://www.uniprot.org/uniprot/A0A8I5KNX5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KT72", "url": "https://www.uniprot.org/uniprot/A0A8I5KT72", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KT72-1", "url": "https://www.uniprot.org/uniprot/A0A8I5KT72-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KUN6", "url": "https://www.uniprot.org/uniprot/A0A8I5KUN6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KUN6-1", "url": "https://www.uniprot.org/uniprot/A0A8I5KUN6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KUX8", "url": "https://www.uniprot.org/uniprot/A0A8I5KUX8", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5KUX8-1", "url": "https://www.uniprot.org/uniprot/A0A8I5KUX8-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QJK9", "url": "https://www.uniprot.org/uniprot/A0A8I5QJK9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QJK9-1", "url": "https://www.uniprot.org/uniprot/A0A8I5QJK9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QKP1", "url": "https://www.uniprot.org/uniprot/A0A8I5QKP1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8I5QKP1-1", "url": "https://www.uniprot.org/uniprot/A0A8I5QKP1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8J9C7E3", "url": "https://www.uniprot.org/uniprot/A0A8J9C7E3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A8J9C7E3-1", "url": "https://www.uniprot.org/uniprot/A0A8J9C7E3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15297-1", "url": "https://www.uniprot.org/uniprot/O15297-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15297-2", "url": "https://www.uniprot.org/uniprot/O15297-2", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC", "length": 605, "header": "sp|O15297-1|PPM1D_HUMAN Isoform 1 of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "isoforms": [ { "isoform_ac": "A0A0S2Z4W0-1", "url": "", "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLV", "length": 158, "header": "tr|A0A0S2Z4W0-1|PPM1D_HUMAN Computationally mapped isoform of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60633854, "end_pos": 60600415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000693102.1", "url": "https://www.ensembl.org/id/ENST00000693102.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509183.1", "url": "https://www.ensembl.org/id/ENSP00000509183.1" } ] } }, { "isoform_ac": "A0A8I5KNX5-1", "url": "", "sequence": { "sequence": "XPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC", "length": 487, "header": "tr|A0A8I5KNX5-1|A0A8I5KNX5_HUMAN Computationally mapped isoform of Protein phosphatase, Mg2+/Mn2+ dependent 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60663550, "end_pos": 60600527, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000686064.1", "url": "https://www.ensembl.org/id/ENST00000686064.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000508480.1", "url": "https://www.ensembl.org/id/ENSP00000508480.1" } ] } }, { "isoform_ac": "A0A8I5KT72-1", "url": "", "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGRETTN", "length": 238, "header": "tr|A0A8I5KT72-1|PPM1D_HUMAN Computationally mapped isoform of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60624483, "end_pos": 60600415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000693196.1", "url": "https://www.ensembl.org/id/ENST00000693196.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510177.1", "url": "https://www.ensembl.org/id/ENSP00000510177.1" } ] } }, { "isoform_ac": "A0A8I5KUN6-1", "url": "", "sequence": { "sequence": "VFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGRKSFLALLPKTPSGQLGRYSAILEQCNEQVWGESCSLETTSTHSQWTC", "length": 271, "header": "tr|A0A8I5KUN6-1|A0A8I5KUN6_HUMAN Computationally mapped isoform of Protein phosphatase, Mg2+/Mn2+ dependent 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60633921, "end_pos": 60600445, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000687355.1", "url": "https://www.ensembl.org/id/ENST00000687355.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509296.1", "url": "https://www.ensembl.org/id/ENSP00000509296.1" } ] } }, { "isoform_ac": "A0A8I5KUX8-1", "url": "", "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGR", "length": 234, "header": "tr|A0A8I5KUX8-1|PPM1D_HUMAN Computationally mapped isoform of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60647892, "end_pos": 60600415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000688505.1", "url": "https://www.ensembl.org/id/ENST00000688505.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000510754.1", "url": "https://www.ensembl.org/id/ENSP00000510754.1" } ] } }, { "isoform_ac": "A0A8I5QJK9-1", "url": "", "sequence": { "sequence": "XGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLETECGCVPQAGLLASSGPPALASQSTVNRNGQRL", "length": 110, "header": "tr|A0A8I5QJK9-1|PPM1D_HUMAN Computationally mapped isoform of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60623539, "end_pos": 60600659, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000689445.1", "url": "https://www.ensembl.org/id/ENST00000689445.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509769.1", "url": "https://www.ensembl.org/id/ENSP00000509769.1" } ] } }, { "isoform_ac": "A0A8I5QKP1-1", "url": "", "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLGD", "length": 159, "header": "tr|A0A8I5QKP1-1|PPM1D_HUMAN Computationally mapped isoform of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60616970, "end_pos": 60600415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000685212.1", "url": "https://www.ensembl.org/id/ENST00000685212.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000509022.1", "url": "https://www.ensembl.org/id/ENSP00000509022.1" } ] } }, { "isoform_ac": "A0A8J9C7E3-1", "url": "", "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKVYSSIVFKLCFNRHQFFG", "length": 438, "header": "tr|A0A8J9C7E3-1|PPM1D_HUMAN Computationally mapped isoform of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60656895, "end_pos": 60600415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000629650.3", "url": "https://www.ensembl.org/id/ENST00000629650.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000486573.2", "url": "https://www.ensembl.org/id/ENSP00000486573.2" } ] } }, { "isoform_ac": "O15297-1", "url": "", "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKSLEEDPWPRVNSKDHIPALVRSNAFSENFLEVSAEIARENVQGVVIPSKDPEPLEENCAKALTLRIHDSLNNSLPIGLVPTNSTNTVMDQKNLKMSTPGQMKAQEIERTPPTNFKRTLEESNSGPLMKKHRRNGLSRSSGAQPASLPTTSQRKNSVKLTMRRRLRGQKKIGNPLLHQHRKTVCVC", "length": 605, "header": "sp|O15297-1|PPM1D_HUMAN Isoform 1 of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60663549, "end_pos": 60600415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000305921.8", "url": "https://www.ensembl.org/id/ENST00000305921.8" }, { "database": "Ensembl Peptide", "id": "ENSP00000306682.2", "url": "https://www.ensembl.org/id/ENSP00000306682.2" } ] } }, { "isoform_ac": "O15297-2", "url": "", "sequence": { "sequence": "MAGLYSLGVSVFSDQGGRKYMEDVTQIVVEPEPTAEEKPSPRRSLSQPLPPRPSPAALPGGEVSGKGPAVAAREARDPLPDAGASPAPSRCCRRRSSVAFFAVCDGHGGREAAQFAREHLWGFIKKQKGFTSSEPAKVCAAIRKGFLACHLAMWKKLAEWPKTMTGLPSTSGTTASVVIIRGMKMYVAHVGDSGVVLGIQDDPKDDFVRAVEVTQDHKPELPKERERIEGLGGSVMNKSGVNRVVWKRPRLTHNGPVRRSTVIDQIPFLAVARALGDLWSYDFFSGEFVVSPEPDTSVHTLDPQKHKYIILGSDGLWNMIPPQDAISMCQDQEEKKYLMGEHGQSCAKMLVNRALGRWRQRMLRADNTSAIVICISPEVDNQGNFTNEDELYLNLTDSPSYNSQETCVMTPSPCSTPPVKDFGFELDSRK", "length": 430, "header": "sp|O15297-2|PPM1D_HUMAN Isoform 2 of Protein phosphatase 1D OS=Homo sapiens OX=9606 GN=PPM1D PE=1 SV=1 CANONICAL=O15297-1" }, "locus": { "chromosome": "17", "start_pos": 60656961, "end_pos": 60600415, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000392995.7", "url": "https://www.ensembl.org/id/ENST00000392995.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000376720.3", "url": "https://www.ensembl.org/id/ENSP00000376720.3" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "T", "relation": "attached", "comment": "O-GlcNAcylation", "start_pos": 537, "start_aa": "Thr", "end_pos": 537, "end_aa": "Thr", "residue": "Thr", "site_lbl": "Thr537", "evidence": [ { "id": "O15297", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15297" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" }, { "id": "O15297", "database": "O-GlcNAc Atlas", "url": "https://oglcnac.org/atlas/detail/O15297" } ] } ], "phosphorylation": [ { "start_pos": 40, "end_pos": 40, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" }, { "database": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" }, { "database": "iPTMnet", "id": "O15297", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15297" } ], "site_lbl": "Ser40" }, { "start_pos": 85, "end_pos": 85, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" }, { "database": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" }, { "database": "iPTMnet", "id": "O15297", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15297" }, { "database": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" } ], "site_lbl": "Ser85" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Mutations in the RUNX2 gene in patients with cleidocranial dysplasia.", "journal": "Human mutation", "date": "2002", "authors": "Otto F, Kanegane H, Mundlos S", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "11857736", "url": "https://glygen.org/publication/PubMed/11857736" } ] }, { "title": "Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter.", "journal": "Molecular and cellular biology", "date": "2002", "authors": "Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS, Li X", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "12391164", "url": "https://glygen.org/publication/PubMed/12391164" } ] }, { "title": "Core-binding factor beta interacts with Runx2 and is required for skeletal development.", "journal": "Nature genetics", "date": "2002", "authors": "Yoshida CA, Furuichi T, Fujita T, Fukuyama R, Kanatani N, Kobayashi S, Satake M, Takada K, Komori T", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "12434152", "url": "https://glygen.org/publication/PubMed/12434152" } ] }, { "title": "Cbfbeta interacts with Runx2 and has a critical role in bone development.", "journal": "Nature genetics", "date": "2002", "authors": "Kundu M, Javed A, Jeon JP, Horner A, Shum L, Eckhaus M, Muenke M, Lian JB, Yang Y, Nuckolls GH, Stein GS, Liu PP", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "12434156", "url": "https://glygen.org/publication/PubMed/12434156" } ] }, { "title": "A twist code determines the onset of osteoblast differentiation.", "journal": "Developmental cell", "date": "2004", "authors": "Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, Wu H, Yu K, Ornitz DM, Olson EN, Justice MJ, Karsenty G", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "15030764", "url": "https://glygen.org/publication/PubMed/15030764" } ] }, { "title": "PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.", "journal": "Genes & development", "date": "2005", "authors": "Lu X, Nannenga B, Donehower LA", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "reference": [ { "type": "PubMed", "id": "15870257", "url": "https://glygen.org/publication/PubMed/15870257" } ] }, { "title": "Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase.", "journal": "Cell death and differentiation", "date": "2006", "authors": "Fujimoto H, Onishi N, Kato N, Takekawa M, Xu XZ, Kosugi A, Kondo T, Imamura M, Oishi I, Yoda A, Minami Y", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "reference": [ { "type": "PubMed", "id": "16311512", "url": "https://glygen.org/publication/PubMed/16311512" } ] }, { "title": "Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation.", "journal": "The Journal of biological chemistry", "date": "2006", "authors": "Qiao M, Shapiro P, Fosbrink M, Rus H, Kumar R, Passaniti A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "16407259", "url": "https://glygen.org/publication/PubMed/16407259" } ] }, { "title": "Dominance of SOX9 function over RUNX2 during skeletogenesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2006", "authors": "Zhou G, Zheng Q, Engin F, Munivez E, Chen Y, Sebald E, Krakow D, Lee B", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "17142326", "url": "https://glygen.org/publication/PubMed/17142326" } ] }, { "title": "Mitotic control of RUNX2 phosphorylation by both CDK1/cyclin B kinase and PP1/PP2A phosphatase in osteoblastic cells.", "journal": "Journal of cellular biochemistry", "date": "2007", "authors": "Rajgopal A, Young DW, Mujeeb KA, Stein JL, Lian JB, van Wijnen AJ, Stein GS", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "17171635", "url": "https://glygen.org/publication/PubMed/17171635" } ] }, { "title": "Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.", "journal": "Oncogene", "date": "2008", "authors": "Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "18223689", "url": "https://glygen.org/publication/PubMed/18223689" } ] }, { "title": "Evaluation of the low-specificity protease elastase for large-scale phosphoproteome analysis.", "journal": "Analytical chemistry", "date": "2008", "authors": "Wang B, Malik R, Nigg EA, Korner R", "evidence": [ { "database": "iPTMnet", "id": "O15297-1", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15297-1" } ], "reference": [ { "type": "PubMed", "id": "19007248", "url": "https://glygen.org/publication/PubMed/19007248" } ] }, { "title": "Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2.", "journal": "Development (Cambridge, England)", "date": "2009", "authors": "Funato N, Chapman SL, McKee MD, Funato H, Morris JA, Shelton JM, Richardson JA, Yanagisawa H", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "19144722", "url": "https://glygen.org/publication/PubMed/19144722" } ] }, { "title": "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.", "journal": "Science signaling", "date": "2009", "authors": "Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" }, { "database": "iPTMnet", "id": "O15297", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15297" } ], "reference": [ { "type": "PubMed", "id": "19690332", "url": "https://glygen.org/publication/PubMed/19690332" } ] }, { "title": "LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).", "journal": "PloS one", "date": "2011", "authors": "An H, Lu X, Liu D, Yarbrough WG", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "reference": [ { "type": "PubMed", "id": "21283629", "url": "https://glygen.org/publication/PubMed/21283629" } ] }, { "title": "Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype.", "journal": "Journal of cellular biochemistry", "date": "2012", "authors": "Pierce AD, Anglin IE, Vitolo MI, Mochin MT, Underwood KF, Goldblum SE, Kommineni S, Passaniti A", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "21913213", "url": "https://glygen.org/publication/PubMed/21913213" } ] }, { "title": "Wip1 promotes RUNX2-dependent apoptosis in p53-negative tumors and protects normal tissues during treatment with anticancer agents.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2012", "authors": "Goloudina AR, Tanoue K, Hammann A, Fourmaux E, Le Guezennec X, Bulavin DV, Mazur SJ, Appella E, Garrido C, Demidov ON", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "22065775", "url": "https://glygen.org/publication/PubMed/22065775" } ] }, { "title": "Wip1 sensitizes p53-negative tumors to apoptosis by regulating the Bax/Bcl-xL ratio.", "journal": "Cell cycle (Georgetown, Tex.)", "date": "2012", "authors": "Goloudina AR, Mazur SJ, Appella E, Garrido C, Demidov ON", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "22544321", "url": "https://glygen.org/publication/PubMed/22544321" } ] }, { "title": "Toward a comprehensive characterization of a human cancer cell phosphoproteome.", "journal": "Journal of proteome research", "date": "2013", "authors": "Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" }, { "database": "iPTMnet", "id": "O15297", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15297" } ], "reference": [ { "type": "PubMed", "id": "23186163", "url": "https://glygen.org/publication/PubMed/23186163" } ] }, { "title": "Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.", "journal": "Nature", "date": "2013", "authors": "Ruark E, Snape K, Humburg P, Loveday C, Bajrami I, Brough R, Rodrigues DN, Renwick A, Seal S, Ramsay E, Duarte Sdel V, Rivas MA, Warren-Perry M, Zachariou A, Campion-Flora A, Hanks S, Murray A, Ansari Pour N, Douglas J, Gregory L, Rimmer A, Walker NM, Yang TP, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Eccles D, Evans DG, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Gore M, Houlston R, Brown MA, Caufield MJ, Deloukas P, McCarthy MI, Todd JA, Turnbull C, Reis-Filho JS, Ashworth A, Antoniou AC, Lord CJ, Donnelly P, Rahman N", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "reference": [ { "type": "PubMed", "id": "23242139", "url": "https://glygen.org/publication/PubMed/23242139" } ] }, { "title": "Cbfbeta deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfbeta required for skeletal development.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2014", "authors": "Chen W, Ma J, Zhu G, Jules J, Wu M, McConnell M, Tian F, Paulson C, Zhou X, Wang L, Li YP", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "24850862", "url": "https://glygen.org/publication/PubMed/24850862" } ] }, { "title": "Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.", "journal": "Cell", "date": "2016", "authors": "Yang Xinping, Coulombe-Huntington Jasmin, Kang Shuli, Sheynkman Gloria M, Hao Tong, Richardson Aaron, Sun Song, Yang Fan, Shen Yun A, Murray Ryan R, Spirohn Kerstin, Begg Bridget E, Duran-Frigola Miquel, MacWilliams Andrew, Pevzner Samuel J, Zhong Quan, Trigg Shelly A, Tam Stanley, Ghamsari Lila, Sahni Nidhi, Yi Song, Rodriguez Maria D, Balcha Dawit, Tan Guihong, Costanzo Michael, Andrews Brenda, Boone Charles, Zhou Xianghong J, Salehi-Ashtiani Kourosh, Charloteaux Benoit, Chen Alyce A, Calderwood Michael A, Aloy Patrick, Roth Frederick P, Hill David E, Iakoucheva Lilia M, Xia Yu, Vidal Marc", "evidence": [ { "database": "UniProtKB", "id": "A0A0S2Z4W0", "url": "https://www.uniprot.org/uniprot/A0A0S2Z4W0" } ], "reference": [ { "type": "PubMed", "id": "26871637", "url": "https://glygen.org/publication/PubMed/26871637" } ] }, { "title": "De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome.", "journal": "American journal of human genetics", "date": "2017", "authors": "Jansen S, Geuer S, Pfundt R, Brough R, Ghongane P, Herkert JC, Marco EJ, Willemsen MH, Kleefstra T, Hannibal M, Shieh JT, Lynch SA, Flinter F, FitzPatrick DR, Gardham A, Bernhard B, Ragge N, Newbury-Ecob R, Bernier R, Kvarnung M, Magnusson EA, Wessels MW, van Slegtenhorst MA, Monaghan KG, de Vries P, Veltman JA, Lord CJ, Vissers LE, de Vries BB", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "reference": [ { "type": "PubMed", "id": "28343630", "url": "https://glygen.org/publication/PubMed/28343630" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O15297", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15297" }, { "database": "O-GlcNAc Atlas", "id": "O15297", "url": "https://oglcnac.org/atlas/detail/O15297" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "PPM1D activity promotes the replication stress caused by cyclin E1 overexpression.", "journal": "Molecular oncology", "date": "2024-01", "authors": "Martinikova Andra S, Stoyanov Miroslav, Oravetzova Anna, Kok Yannick P, Yu Shibo, Dobrovolna Jana, Janscak Pavel, van Vugt Marcel, Macurek Libor", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" } ], "reference": [ { "type": "PubMed", "id": "37067201", "url": "https://glygen.org/publication/PubMed/37067201" } ] }, { "title": "Jansen-de Vries syndrome: Expansion of the PPM1D clinical and phenotypic spectrum in 34 families.", "journal": "American journal of medical genetics. Part A", "date": "2023-05-14", "authors": "Wojcik Monica H, Srivastava Siddharth, Agrawal Pankaj B, Balci Tugce B, Callewaert Bert, Calvo Pier Luigi, Carli Diana, Caudle Michelle, Colaiacovo Samantha, Cross Laura, Demetriou Kalliope, Drazba Katy, Dutra-Clarke Marina, Edwards Matthew, Genetti Casie A, Grange Dorothy K, Hickey Scott E, Isidor Bertrand, K\u00fcry S\u00e9bastien, Lachman Herbert M, Lavillaureix Alinoe, Lyons Michael J, Marcelis Carlo, Marco Elysa J, Martinez-Agosto Julian A, Nowak Catherine, Pizzol Antonio, Planes Marc, Prijoles Eloise J, Riberi Evelise, Rush Eric T, Russell Bianca E, Sachdev Rani, Schmalz Betsy, Shears Deborah, Stevenson David A, Wilson Kate, Jansen Sandra, de Vries Bert B A, Curry Cynthia J", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" } ], "reference": [ { "type": "PubMed", "id": "37183572", "url": "https://glygen.org/publication/PubMed/37183572" } ] }, { "title": "A Case Study on PPM1D and 9 Other Shared Germline Alterations in a Family.", "journal": "Asian Pacific journal of cancer prevention : APJCP", "date": "2023-06-01", "authors": "Biswas Shristi, Manekar Swati, Bakshi Sonal Rajiv", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" } ], "reference": [ { "type": "PubMed", "id": "37378944", "url": "https://glygen.org/publication/PubMed/37378944" } ] }, { "title": "PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.", "journal": "Blood", "date": "2023-12-14", "authors": "Miller Peter G, Sperling Adam S, Mayerhofer Christina, McConkey Marie E, Ellegast Jana M, Da Silva Carmen, Cohen Drew N, Wang Chuqi, Sharda Azeem, Yan Ni, Saha Subha, Schluter Cameron, Schechter Ilexa, S\u0142abicki Miko\u0142aj, Sandoval Brittany, Kahn Josephine, Boettcher Steffen, Gibson Christopher J, Scadden David T, Stegmaier Kimberly, Bhatt Shruti, Lindsley R Coleman, Ebert Benjamin L", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" } ], "reference": [ { "type": "PubMed", "id": "37595362", "url": "https://glygen.org/publication/PubMed/37595362" } ] }, { "title": "Low-Frequency PPM1D Gene Mutations Affect Treatment Response to CD19-Targeted CAR T-Cell Therapy in Large B-Cell Lymphoma.", "journal": "Current oncology (Toronto, Ont.)", "date": "2023-12-13", "authors": "Seipel Katja, Frey Mich\u00e8le, Nilius Henning, Akhoundova Dilara, Banz Yara, Bacher Ulrike, Pabst Thomas", "evidence": [ { "database": "RefSeq", "id": "NP_003611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003611" } ], "reference": [ { "type": "PubMed", "id": "38132396", "url": "https://glygen.org/publication/PubMed/38132396" } ] }, { "title": "Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "date": "1997", "authors": "Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, Mercer WE, Vande Woude GF, O'Connor PM, Appella E", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "reference": [ { "type": "PubMed", "id": "9177166", "url": "https://glygen.org/publication/PubMed/9177166" } ] }, { "title": "Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development.", "journal": "Cell", "date": "1997", "authors": "Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "9182764", "url": "https://glygen.org/publication/PubMed/9182764" } ] }, { "title": "Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia.", "journal": "Nature genetics", "date": "1997", "authors": "Lee B, Thirunavukkarasu K, Zhou L, Pastore L, Baldini A, Hecht J, Geoffroy V, Ducy P, Karsenty G", "evidence": [ { "database": "Reactome", "id": "R-HSA-8878166", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166" } ], "reference": [ { "type": "PubMed", "id": "9207800", "url": "https://glygen.org/publication/PubMed/9207800" } ] } ], "pathway": [ { "id": "hsa:8493", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:8493", "resource": "KEGG Pathway" }, { "id": "R-HSA-8878166", "name": "Transcriptional regulation by RUNX2", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-8878166", "resource": "Reactome", "description": "Transcriptional regulation by RUNX2" } ], "orthologs": [ { "uniprot_canonical_ac": "B1WCA0-1", "protein_name": "Protein phosphatase, Mg2+/Mn2+ dependent, 1D", "gene_name": "Ppm1d", 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"https://www.uniprot.org/uniprot/O15297" } ], "pmid": "" }, { "name": "heterochromatin formation", "id": "GO:0031507", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031507", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "pmid": "" }, { "name": "regulation of transcription initiation by RNA polymerase II", "id": "GO:0060260", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060260", "evidence": [ { "database": "UniProtKB", "id": "O15297", "url": "https://www.uniprot.org/uniprot/O15297" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 237, "end_pos": 239, "annotation": "n_glycosylation_sequon" }, { "start_pos": 367, "end_pos": 369, "annotation": "n_glycosylation_sequon" }, { "start_pos": 384, "end_pos": 386, "annotation": "n_glycosylation_sequon" }, { "start_pos": 394, "end_pos": 396, "annotation": "n_glycosylation_sequon" }, { "start_pos": 491, "end_pos": 493, "annotation": "n_glycosylation_sequon" }, { "start_pos": 502, "end_pos": 504, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "20629", "name": "", "equation": "H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q4KLK9-1", "P62142-1", "Q3SWT6-1", "Q5I0E6-1", "Q5FWT7-1", "Q3B7T6-1", "B4F7B7-1", "Q5FVI9-1", "P63329-1", "P20651-1", "Q66H71-1", "Q80Z30-1", "Q91XQ2-1", "B2RZ50-1", "P63088-1", "Q64346-1", "P0C595-1", "Q6AXW7-1", "Q62767-1", "Q63340-1", "O54838-1", "Q64623-1", "Q9JIM4-1", "P63331-1", "O54857-1", "Q9Z1Z6-1", "F1LNI5-1", "Q562B5-1", "Q641Y6-1", "P20650-1", "P35815-1", "P62138-1", "Q5BJ92-1", "Q5M821-1", "Q5XIS1-1", "Q9WTR8-1", "Q9WVR7-1", "Q64620-1", "P53042-1", "P62716-1", "P0C089-1", "A0A8I6AF61-1", "A0A0G2K9N1-1", "D4A520-1", "A0A0G2K0J7-1", "D3ZNK9-1", "D3ZP99-1", "D4A3W6-1", "E2CWF0-1", "D3ZN69-1", "Q2YDV1-1", "M0R5X1-1", "D3ZBG7-1", "B1WC24-1", "Q8VD52-1", "M0R4W4-1", "A6HQ12-1", "A0A8I5ZU99-1", "A6K136-1", "Q8NI37-1", "P36873-1", "Q9Y5B0-1", "P62140-1", "Q9UNH5-1", "A4D256-1", "O60729-1", "Q16667-1", "P51452-1", "O95476-1", "O14595-1", "O15194-1", "Q9BV47-1", "P62136-1", "Q9BVJ7-1", "Q9H1R2-1", "Q9BY84-1", "Q9NRW4-1", "Q16828-1", "Q9H596-1", "Q13202-1", "Q4G0W2-1", "Q99956-1", "Q8NEJ0-1", "Q6B8I1-1", "B3EWF7-1", "P28562-1", "Q16690-1", "Q13115-1", "Q9GZU7-1", "Q9UNI6-1", "Q9Y6W6-1", "Q68J44-1", "Q16829-1", "Q8WTR2-1", "Q9BRF8-1", "O95147-1", "Q9UII6-1", "Q9H0C8-1", "Q99502-1", "Q9ULR3-1", "P60510-1", "P49593-1", "O15297-1", "Q5SGD2-1", "O15355-1", "Q8WY54-2", "Q8N819-1", "Q5JR12-1", "O75688-1", "O14830-1", "O14829-1", "P16298-1", "Q8IXW5-1", "O60346-1", "Q6ZVD8-1", "P67775-1", "P48454-1", "P53041-1", "O00743-1", "Q96MI6-5", "Q8WUK0-1", "P35813-1", "P62714-1", "Q96HS1-1", "Q08209-1", "P60484-1", "Q8N3J5-1", "Q8TE77-1", "Q76I76-1", "Q8WVY7-1", "Q9NP77-1", "Q8WYL5-1", "Q96GD0-1", "A0A1W2PQ27-1", "A0A1W2PR75-1", "A0A1W2PQC6-1", "A0A1W2PQD8-1", "A0A1W2PQJ5-1", "A0A1W2PQ64-1", "Q92562-1", "P63087-1", "Q9D7X3-1", "Q6PFY9-1", "Q3TP92-1", "P58465-1", "P58466-1", "Q7TSG2-1", "Q8BFS6-1", "Q6GQT0-1", "Q810P3-1", "Q8R4V2-1", "Q99N11-1", "Q9JLY7-1", "Q9WUA5-1", "O09112-1", "Q8BTR5-1", "Q9DBB1-1", "Q9D700-1", "Q8BX07-1", "Q9QYJ7-1", "Q8VE01-1", "Q91Z46-1", "P28563-1", "Q8K4T5-1", "Q6NT99-1", "Q8BK84-1", "Q8BFV3-1", "P97767-1", "Q9D0T2-1", "Q9D9D8-1", "Q9ESS0-1", "Q8R0F6-1", "Q149T7-1", "Q3UYC0-1", "P62141-1", "O35385-1", "Q8BX10-1", "Q6NVE9-1", "Q8BU27-3", "Q80TL0-1", "Q8BGL1-1", "Q8BHN0-1", "Q8CGA0-1", "Q9QZ67-1", "O35655-1", "P97470-1", "Q8BXA7-1", "Q8CHE4-1", "P49443-1", "Q61074-1", "Q5SW75-1", "P62715-1", "P63328-1", "Q8K330-1", "Q9CY97-1", "P62137-1", "P36993-1", "P48453-1", "P48455-1", "Q60676-1", "Q66GT5-1", "Q76I79-1", "Q9CQR6-1", "Q8VC34-1", "P63330-1", "O08586-1", "Q8BXN7-1", "Q8BGR9-1", "P60487-1", "Q91WF7-1", "P14747-1", "P20604-1", "P23594-1", "P23595-1", "P25646-1", "P26570-1", "P32598-1", "P33329-1", "P38757-1", "P38797-1", "P23287-1", "P53043-1", "P32345-1", "P32838-1", "P32945-1", "P38148-1", "P39966-1", "P40084-1", "P53538-1", "P34221-1", "P35182-1", "P38089-1", "Q03254-1", "Q12378-1", "Q54GL8-1", "Q54IJ8-1", "Q54M72-1", "Q54M73-1", "Q54QE5-1", "Q558Z3-1", "Q54R42-1", "Q55E39-1", "Q54T01-1", "Q54T76-1", "Q54WS9-1", "Q556S4-1", "Q55BI8-1", "Q55CS8-1", "Q8ST13-1", "Q9U9A3-1", "Q75JA4-1", "O15757-1", "O15743-1", "Q54RD6-1", "Q54Y32-1", "Q556Y8-1", "Q55CS7-1", "Q7YSW8-1", "Q9XYL0-1", "Q9XZE5-1", "Q9Y0B7-1", "Q8T9S7-1", "Q05547-1", "Q27884-1", "Q7K4Q5-1", "Q9VAH4-1", "A8DYY5-1", "O76932-1", "P11612-1", "P40421-1", "P48461-1", "Q6NN85-1", "Q86BN8-1", "Q9VJ07-1", "P12982-1", "P48462-1", "M9PFN0-1", "O46084-1", "Q9VRG7-1", "P23696-1", "Q27889-1", "Q9VXF1-1", "X2JEB8-1", "A8QI94-1", "P48456-1", "Q9VWE4-1", "Q9VVW5-1", "Q9VWF4-1", "Q7KVM5-1", "Q9XZ16-1", "Q9VQL9-1", "Q9W0E2-1", "Q9W3R1-1", "Q5LJN2-1", "Q9W2A5-1", "Q9W147-1", "Q7KMQ6-1", "Q961C5-1", "Q9W173-1", "M9PI51-1", "Q9VZS0-1", "Q7JY68-1" ], "evidence": [ { "id": "20629", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/20629" } ] }, { "id": "47004", "name": "", "equation": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "P62142-1", "Q3SWT6-1", "Q4KLK9-1", "Q5I0E6-1", "P20651-1", "Q5FWT7-1", "A0A0G2JYA4-1", "Q3B7T6-1", "B4F7B7-1", "Q5FVI9-1", "P63329-1", "Q66H71-1", "Q80Z30-1", "Q91XQ2-1", "B2RZ50-1", "P63088-1", "Q64346-1", "P0C595-1", "Q6AXW7-1", "Q62767-1", "Q63340-1", "O54838-1", "Q64623-1", "Q9JIM4-1", "P63331-1", "O54857-1", "Q9Z1Z6-1", "Q9WVR7-1", "F1LNI5-1", "P20650-1", "P35815-1", "P62138-1", "Q562B5-1", "Q5BJ92-1", "Q5M821-1", "Q5XIS1-1", "Q641Y6-1", "Q9WTR8-1", "Q64620-1", "P53042-1", "P62716-1", "P0C089-1", "A0A8I6AF61-1", "A0A0G2K9N1-1", "Q2YDV1-1", "E2CWF0-1", "D4A520-1", "D3ZN69-1", "A0A0G2K0J7-1", "D3ZNK9-1", "D4A3W6-1", "F1M4Q5-1", "M0R5X1-1", "A0A8I6B0P9-1", "D3ZBG7-1", "B1WC24-1", "M0R4W4-1", "A6HQ12-1", "A0A8I5ZU99-1", "Q8NI37-1", "P36873-1", "P60510-1", "Q16667-1", "Q9Y5B0-1", "P48454-1", "Q08209-1", "P53041-1", "P62140-1", "P62714-1", "Q9UNH5-1", "A4D256-1", "O60729-1", "P51452-1", "O95476-1", "O14595-1", "O15194-1", "O14829-1", "Q9BV47-1", "P62136-1", "O95147-1", "Q9BVJ7-1", "Q9H1R2-1", "Q9BY84-1", "Q9NRW4-1", "Q16828-1", "Q9H596-1", "Q13202-1", "Q4G0W2-1", "Q99956-1", "Q8NEJ0-1", "Q6B8I1-1", "B3EWF7-1", "P28562-1", "Q16690-1", "Q13115-1", "Q9GZU7-1", "Q9UNI6-1", "Q9Y6W6-1", "Q05923-1", "Q68J44-1", "Q16829-1", "Q8WTR2-1", "Q9BRF8-1", "Q9UII6-1", "Q9H0C8-1", "Q99502-1", "Q9ULR3-1", "P49593-1", "O15297-1", "Q5SGD2-1", "O15355-1", "Q8IXW5-1", "Q8WY54-2", "Q8N819-1", "Q5JR12-1", "O75688-1", "O14830-1", "O60346-1", "Q6ZVD8-1", "P67775-1", "P16298-1", "O00743-1", "Q96MI6-5", "Q8WUK0-1", "P35813-1", "Q96HS1-1", "P60484-1", "Q8TE77-1", "Q76I76-1", "Q8WYL5-1", "Q8WVY7-1", "Q9NP77-1", "A0A1W2PQ27-1", "A0A1W2PR75-1", "A0A1W2PQC6-1", "A0A1W2PQD8-1", "A0A1W2PQJ5-1", "A0A1W2PQ64-1", "P63087-1", "P48453-1", "Q9D7X3-1", "O35655-1", "Q9CQR6-1", "Q6PFY9-1", "Q3TP92-1", "P58465-1", "P58466-1", "Q7TSG2-1", "Q8BFS6-1", "Q6GQT0-1", "Q810P3-1", "Q8R4V2-1", "Q99N11-1", "Q9JLY7-1", "Q9WUA5-1", "O09112-1", "Q8BTR5-1", "Q9DBB1-1", "Q9D700-1", "Q8BX07-1", "Q9QYJ7-1", "Q8VE01-1", "Q91Z46-1", "P28563-1", "Q8K4T5-1", "Q6NT99-1", "Q8BK84-1", "Q8BFV3-1", "Q05922-1", "P97767-1", "Q9D0T2-1", "Q9D9D8-1", "Q9ESS0-1", "Q8R0F6-1", "Q149T7-1", "Q3UYC0-1", "P62141-1", "O35385-1", "Q8BX10-1", "Q6NVE9-1", "Q8BU27-3", "Q80TL0-1", "Q8BGL1-1", "Q8BHN0-1", "Q8CGA0-1", "Q9QZ67-1", "Q76I79-1", "P97470-1", "Q8BXA7-1", "Q8CHE4-1", "P49443-1", "Q61074-1", "Q5SW75-1", "P62715-1", "P63328-1", "Q8VC34-1", "Q8K330-1", "Q9CY97-1", "P62137-1", "P36993-1", "P48455-1", "Q60676-1", "Q66GT5-1", "P63330-1", "O08586-1", "Q7TNL7-1", "Q8BGR9-1", "Q1HL35-1", "P14747-1", "P20604-1", "P23594-1", "P23595-1", "P25646-1", "P26570-1", "P32598-1", "P33329-1", "P38757-1", "P38797-1", "P23287-1", "P53043-1", "P32345-1", "P32838-1", "P32945-1", "P38148-1", "P39966-1", "P40084-1", "P53538-1", "P34221-1", "P35182-1", "P38089-1", "Q03254-1", "Q12378-1", "Q54GL8-1", "Q54IJ8-1", "Q54M72-1", "Q54M73-1", "Q54QE5-1", "Q558Z3-1", "Q54R42-1", "Q54T01-1", "Q54T76-1", "Q54WS9-1", "Q556S4-1", "Q55BI8-1", "Q55CS8-1", "Q55E39-1", "Q8ST13-1", "Q9U9A3-1", "Q75JA4-1", "O15743-1", "O15757-1", "Q54RD6-1", "Q54Y32-1", "Q556Y8-1", "Q55CS7-1", "Q7YSW8-1", "Q9XYL0-1", "Q9XZE5-1", "Q9Y0B7-1", "Q8T9S7-1", "Q05547-1", "Q27884-1", "Q7K4Q5-1", "Q9VAH4-1", "A8DYY5-1", "O76932-1", "P11612-1", "P40421-1", "P48461-1", "Q6NN85-1", "Q9VJ07-1", "P12982-1", "P48462-1", "Q86BN8-1", "O46084-1", "Q9VRG7-1", "P23696-1", "Q27889-1", "Q9VXF1-1", "X2JEB8-1", "A8QI94-1", "Q9VVW5-1", "P48456-1", "Q9VWE4-1", "Q9VWF4-1", "Q7KVM5-1", "Q9XZ16-1", "Q95TV5-1", "Q9VQL9-1", "Q9W0E2-1", "Q9W3R1-1", "Q5LJN2-1", "Q9W2A5-1", "Q9W147-1", "Q7KMQ6-1", "Q961C5-1", "Q9W173-1", "M9PI51-1", "Q9VZS0-1", "Q7JY68-1" ], "evidence": [ { "id": "47004", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/47004" } ] }, { "id": "R-HSA-9008822", "name": "PPM1D dephosphorylates RUNX2", "equation": "", "summary": "PPM1D (Wip1), a serine/threonine phosphatase, dephosphorylates RUNX2 on serine residue S432. Since it has not been tested whether S432 affects bindng of RUNX2 to CBFB, PPM1D is shown to dephosphorylate RUNX2 in the context of its complex with CBFB. The kinase responsible for RUNX2 phosphorylation at S432 is not known. PPM1D-mediated dephosphorylation of RUNX2 promotes RUNX2-mediated transcriptional activation of BAX and may play an important role in inducing apoptosis in TP53 negative tumor cells (Goloudina, Tanoue et al. 2012, Goloudina, Mazur et al. 2012).", "cellular_location": "nucleoplasm", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O15297-1" ], "evidence": [ { "id": "R-HSA-9008822", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-9008822" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JYA4", "gene_name": "LOC100362453", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2JYA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JYA4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A0G2JYA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JYA4" } ] } ] }, { "uniprot_ac": "A0A0G2K0J7", "gene_name": "Ctdp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K0J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0J7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A0G2K0J7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K0J7" } ] } ] }, { "uniprot_ac": "A0A0G2K9N1", "gene_name": "Dusp13b", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A0G2K9N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K9N1" } ] } ] }, { "uniprot_ac": "A0A1W2PQ27", "gene_name": "SSU72L1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1W2PQ27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PQ27" } ] } ] }, { "uniprot_ac": "A0A1W2PQ64", "gene_name": "SSU72L5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1W2PQ64", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PQ64" } ] } ] }, { "uniprot_ac": "A0A1W2PQC6", "gene_name": "SSU72L4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1W2PQC6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PQC6" } ] } ] }, { "uniprot_ac": "A0A1W2PQD8", "gene_name": "SSU72L2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1W2PQD8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PQD8" } ] } ] }, { "uniprot_ac": "A0A1W2PQJ5", "gene_name": "SSU72L3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1W2PQJ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PQJ5" } ] } ] }, { "uniprot_ac": "A0A1W2PR75", "gene_name": "SSU72L6", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A1W2PR75", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A1W2PR75" } ] } ] }, { "uniprot_ac": "A0A8I5ZU99", "gene_name": "Ppm1l", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I5ZU99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZU99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8I5ZU99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZU99" } ] } ] }, { "uniprot_ac": "A0A8I6AF61", "gene_name": "Dusp3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A0A8I6AF61", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AF61" } ] } ] }, { "uniprot_ac": "A0A8I6B0P9", "gene_name": "Ssh1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A0A8I6B0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6B0P9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A0A8I6B0P9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6B0P9" } ] } ] }, { "uniprot_ac": "A4D256", "gene_name": "CDC14C", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A4D256", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A4D256" } ] } ] }, { "uniprot_ac": "A6HQ12", "gene_name": "Dusp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "A6HQ12", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6HQ12" } ] } ] }, { "uniprot_ac": "A6K136", "gene_name": "Ppm1k", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A6K136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6K136" } ] }, { "ec_number": "3.1.3.52", "activity": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "A6K136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6K136" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A6K136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A6K136" } ] } ] }, { "uniprot_ac": "A8DYY5", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A8DYY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8DYY5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A8DYY5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8DYY5" } ] } ] }, { "uniprot_ac": "A8QI94", "gene_name": "Pp1-Y1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "A8QI94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8QI94" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "A8QI94", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A8QI94" } ] } ] }, { "uniprot_ac": "B1WC24", "gene_name": "Ctdsp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B1WC24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC24" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B1WC24", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC24" } ] } ] }, { "uniprot_ac": "B2RZ50", "gene_name": "Cdkn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B2RZ50", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RZ50" } ] } ] }, { "uniprot_ac": "B3EWF7", "gene_name": "EPM2A", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B3EWF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B3EWF7" } ] } ] }, { "uniprot_ac": "B4F7B7", "gene_name": "Dusp15", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "B4F7B7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B4F7B7" } ] } ] }, { "uniprot_ac": "D3ZBG7", "gene_name": "Dusp10", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBG7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D3ZBG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBG7" } ] } ] }, { "uniprot_ac": "D3ZN69", "gene_name": "Ppef2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZN69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZN69" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D3ZN69", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZN69" } ] } ] }, { "uniprot_ac": "D3ZNK9", "gene_name": "Dusp8", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZNK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZNK9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D3ZNK9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZNK9" } ] } ] }, { "uniprot_ac": "D3ZP99", "gene_name": "Ppm1n", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D3ZP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP99" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D3ZP99", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZP99" } ] } ] }, { "uniprot_ac": "D4A3W6", "gene_name": "Dusp16", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D4A3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3W6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D4A3W6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A3W6" } ] } ] }, { "uniprot_ac": "D4A520", "gene_name": "Pptc7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "D4A520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A520" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "D4A520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A520" } ] } ] }, { "uniprot_ac": "E2CWF0", "gene_name": "Ppp3cc", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "E2CWF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E2CWF0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "E2CWF0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E2CWF0" } ] } ] }, { "uniprot_ac": "F1LNI5", "gene_name": "Ppm1g", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1LNI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNI5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1LNI5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LNI5" } ] } ] }, { "uniprot_ac": "F1M4Q5", "gene_name": "Ssh2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "F1M4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M4Q5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "F1M4Q5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M4Q5" } ] } ] }, { "uniprot_ac": "M0R4W4", "gene_name": "Ctdspl", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "M0R4W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4W4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "M0R4W4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R4W4" } ] } ] }, { "uniprot_ac": "M0R5X1", "gene_name": "Ctdsp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "M0R5X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R5X1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "M0R5X1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R5X1" } ] } ] }, { "uniprot_ac": "M9PFN0", "gene_name": "hzg", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "M9PFN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PFN0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "M9PFN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PFN0" } ] } ] }, { "uniprot_ac": "M9PI51", "gene_name": "Dmel\\CG10089", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "M9PI51", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M9PI51" } ] } ] }, { "uniprot_ac": "O00743", "gene_name": "PPP6C", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O00743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00743" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O00743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O00743" } ] } ] }, { "uniprot_ac": "O08586", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O08586", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08586" } ] } ] }, { "uniprot_ac": "O09112", "gene_name": "Dusp8", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O09112", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09112" } ] } ] }, { "uniprot_ac": "O14595", "gene_name": "CTDSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O14595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14595" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O14595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14595" } ] } ] }, { "uniprot_ac": "O14829", "gene_name": "PPEF1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O14829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14829" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O14829", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14829" } ] } ] }, { "uniprot_ac": "O14830", "gene_name": "PPEF2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O14830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14830" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O14830", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14830" } ] } ] }, { "uniprot_ac": "O15194", "gene_name": "CTDSPL", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O15194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15194" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O15194", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15194" } ] } ] }, { "uniprot_ac": "O15297", "gene_name": "PPM1D", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O15297", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15297" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O15297", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15297" } ] } ] }, { "uniprot_ac": "O15355", "gene_name": "PPM1G", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O15355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15355" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O15355", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15355" } ] } ] }, { "uniprot_ac": "O15743", "gene_name": "spnA", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O15743", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15743" } ] } ] }, { "uniprot_ac": "O15757", "gene_name": "pppB", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O15757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15757" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O15757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15757" } ] } ] }, { "uniprot_ac": "O35385", "gene_name": "Ppef2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O35385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35385" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O35385", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35385" } ] } ] }, { "uniprot_ac": "O35655", "gene_name": "Ppef1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O35655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35655" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O35655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35655" } ] } ] }, { "uniprot_ac": "O46084", "gene_name": "Pgam5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O46084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46084" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O46084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O46084" } ] } ] }, { "uniprot_ac": "O54838", "gene_name": "Dusp5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O54838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54838" } ] } ] }, { "uniprot_ac": "O54857", "gene_name": "Pten", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "O54857", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54857" } ] } ] }, { "uniprot_ac": "O60346", "gene_name": "PHLPP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O60346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60346" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O60346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60346" } ] } ] }, { "uniprot_ac": "O60729", "gene_name": "CDC14B", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O60729", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60729" } ] } ] }, { "uniprot_ac": "O75688", "gene_name": "PPM1B", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O75688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75688" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O75688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75688" } ] } ] }, { "uniprot_ac": "O76932", "gene_name": "Pp4-19C", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O76932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76932" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O76932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O76932" } ] } ] }, { "uniprot_ac": "O95147", "gene_name": "DUSP14", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "O95147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95147" } ] } ] }, { "uniprot_ac": "O95476", "gene_name": "CTDNEP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "O95476", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95476" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "O95476", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O95476" } ] } ] }, { "uniprot_ac": "P0C089", "gene_name": "Ptpmt1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "P0C089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C089" } ] } ] }, { "uniprot_ac": "P0C595", "gene_name": "Dusp29", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P0C595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C595" } ] } ] }, { "uniprot_ac": "P11612", "gene_name": "PpY-55A", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P11612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11612" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P11612", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11612" } ] } ] }, { "uniprot_ac": "P12982", "gene_name": "Pp1-87B", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P12982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12982" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P12982", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12982" } ] } ] }, { "uniprot_ac": "P14747", "gene_name": "CMP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P14747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14747" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P14747", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14747" } ] } ] }, { "uniprot_ac": "P16298", "gene_name": "PPP3CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P16298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16298" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P16298", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16298" } ] } ] }, { "uniprot_ac": "P20604", "gene_name": "SIT4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P20604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20604" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P20604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20604" } ] } ] }, { "uniprot_ac": "P20650", "gene_name": "Ppm1a", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P20650", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20650" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P20650", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20650" } ] } ] }, { "uniprot_ac": "P20651", "gene_name": "Ppp3cb", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P20651", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20651" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P20651", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20651" } ] } ] }, { "uniprot_ac": "P23287", "gene_name": "CNA1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P23287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23287" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P23287", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23287" } ] } ] }, { "uniprot_ac": "P23594", "gene_name": "PPH21", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P23594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23594" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P23594", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23594" } ] } ] }, { "uniprot_ac": "P23595", "gene_name": "PPH22", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P23595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23595" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P23595", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23595" } ] } ] }, { "uniprot_ac": "P23696", "gene_name": "mts", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P23696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23696" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P23696", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23696" } ] } ] }, { "uniprot_ac": "P25646", "gene_name": "PTC6", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] }, { "ec_number": "3.1.3.43", "activity": "H2O + O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate.", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] }, { "ec_number": "3.1.3.43", "activity": "", "evidence": [ { "id": "P25646", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25646" } ] } ] }, { "uniprot_ac": "P26570", "gene_name": "PPZ1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P26570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26570" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P26570", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26570" } ] } ] }, { "uniprot_ac": "P28562", "gene_name": "DUSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P28562", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28562" } ] } ] }, { "uniprot_ac": "P28563", "gene_name": "Dusp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P28563", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28563" } ] } ] }, { "uniprot_ac": "P32345", "gene_name": "PPH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P32345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32345" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P32345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32345" } ] } ] }, { "uniprot_ac": "P32598", "gene_name": "GLC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P32598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32598" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P32598", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32598" } ] } ] }, { "uniprot_ac": "P32838", "gene_name": "PPG1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P32838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32838" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P32838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32838" } ] } ] }, { "uniprot_ac": "P32945", "gene_name": "PPQ1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P32945", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32945" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P32945", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32945" } ] } ] }, { "uniprot_ac": "P33329", "gene_name": "PPZ2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P33329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33329" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P33329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33329" } ] } ] }, { "uniprot_ac": "P34221", "gene_name": "PTC3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P34221", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34221" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P34221", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34221" } ] } ] }, { "uniprot_ac": "P35182", "gene_name": "PTC1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P35182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35182" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P35182", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35182" } ] } ] }, { "uniprot_ac": "P35813", "gene_name": "PPM1A", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P35813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35813" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P35813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35813" } ] } ] }, { "uniprot_ac": "P35815", "gene_name": "Ppm1b", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P35815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35815" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P35815", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35815" } ] } ] }, { "uniprot_ac": "P36873", "gene_name": "PPP1CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P36873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36873" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P36873", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36873" } ] } ] }, { "uniprot_ac": "P36993", "gene_name": "Ppm1b", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P36993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36993" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P36993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36993" } ] } ] }, { "uniprot_ac": "P38089", "gene_name": "PTC4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P38089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38089" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P38089", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38089" } ] } ] }, { "uniprot_ac": "P38148", "gene_name": "PPS1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P38148", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38148" } ] } ] }, { "uniprot_ac": "P38757", "gene_name": "NEM1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P38757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38757" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P38757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38757" } ] } ] }, { "uniprot_ac": "P38797", "gene_name": "PTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P38797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38797" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P38797", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P38797" } ] } ] }, { "uniprot_ac": "P39966", "gene_name": "PTC2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P39966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39966" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P39966", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39966" } ] } ] }, { "uniprot_ac": "P40084", "gene_name": "RTR1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P40084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40084" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P40084", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40084" } ] } ] }, { "uniprot_ac": "P40421", "gene_name": "rdgC", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P40421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40421" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P40421", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P40421" } ] } ] }, { "uniprot_ac": "P48453", "gene_name": "Ppp3cb", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48453", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48453" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48453", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48453" } ] } ] }, { "uniprot_ac": "P48454", "gene_name": "PPP3CC", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48454" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48454", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48454" } ] } ] }, { "uniprot_ac": "P48455", "gene_name": "Ppp3cc", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48455" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48455" } ] } ] }, { "uniprot_ac": "P48456", "gene_name": "CanA1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48456" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48456", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48456" } ] } ] }, { "uniprot_ac": "P48461", "gene_name": "Pp1alpha-96A", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48461" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48461", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48461" } ] } ] }, { "uniprot_ac": "P48462", "gene_name": "flw", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P48462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48462" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P48462", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48462" } ] } ] }, { "uniprot_ac": "P49443", "gene_name": "Ppm1a", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P49443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49443" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P49443", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49443" } ] } ] }, { "uniprot_ac": "P49593", "gene_name": "PPM1F", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P49593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49593" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P49593", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49593" } ] } ] }, { "uniprot_ac": "P51452", "gene_name": "DUSP3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P51452", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51452" } ] } ] }, { "uniprot_ac": "P53041", "gene_name": "PPP5C", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P53041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53041" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P53041", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53041" } ] } ] }, { "uniprot_ac": "P53042", "gene_name": "Ppp5c", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P53042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53042" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P53042", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53042" } ] } ] }, { "uniprot_ac": "P53043", "gene_name": "PPT1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P53043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53043" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P53043", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53043" } ] } ] }, { "uniprot_ac": "P53538", "gene_name": "SSU72", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P53538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53538" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P53538", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53538" } ] } ] }, { "uniprot_ac": "P58465", "gene_name": "Ctdspl", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P58465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58465" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P58465", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58465" } ] } ] }, { "uniprot_ac": "P58466", "gene_name": "Ctdsp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P58466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58466" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P58466", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58466" } ] } ] }, { "uniprot_ac": "P60484", "gene_name": "PTEN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "P60484", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60484" } ] } ] }, { "uniprot_ac": "P60487", "gene_name": "Pdxp", "activity": [ { "ec_number": "3.1.3.74", "activity": "H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine.", "evidence": [ { "id": "P60487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60487" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P60487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60487" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P60487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60487" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "P60487", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60487" } ] } ] }, { "uniprot_ac": "P60510", "gene_name": "PPP4C", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P60510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60510" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P60510", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P60510" } ] } ] }, { "uniprot_ac": "P62136", "gene_name": "PPP1CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62136" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62136", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62136" } ] } ] }, { "uniprot_ac": "P62137", "gene_name": "Ppp1ca", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62137" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62137" } ] } ] }, { "uniprot_ac": "P62138", "gene_name": "Ppp1ca", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62138" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62138" } ] } ] }, { "uniprot_ac": "P62140", "gene_name": "PPP1CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62140" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62140" } ] }, { "ec_number": "3.1.3.53", "activity": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "P62140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62140" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "P62140", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62140" } ] } ] }, { "uniprot_ac": "P62141", "gene_name": "Ppp1cb", "activity": [ { "ec_number": "3.1.3.53", "activity": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "P62141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62141" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62141" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "P62141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62141" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62141", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62141" } ] } ] }, { "uniprot_ac": "P62142", "gene_name": "Ppp1cb", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62142" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62142" } ] }, { "ec_number": "3.1.3.53", "activity": "H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate.", "evidence": [ { "id": "P62142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62142" } ] }, { "ec_number": "3.1.3.53", "activity": "", "evidence": [ { "id": "P62142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62142" } ] } ] }, { "uniprot_ac": "P62714", "gene_name": "PPP2CB", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62714" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62714", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62714" } ] } ] }, { "uniprot_ac": "P62715", "gene_name": "Ppp2cb", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62715", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62715" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62715", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62715" } ] } ] }, { "uniprot_ac": "P62716", "gene_name": "Ppp2cb", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P62716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62716" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P62716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P62716" } ] } ] }, { "uniprot_ac": "P63087", "gene_name": "Ppp1cc", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P63087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63087" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P63087", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63087" } ] } ] }, { "uniprot_ac": "P63088", "gene_name": "Ppp1cc", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P63088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63088" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P63088", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63088" } ] } ] }, { "uniprot_ac": "P63328", "gene_name": "Ppp3ca", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P63328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63328" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P63328", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63328" } ] } ] }, { "uniprot_ac": "P63329", "gene_name": "Ppp3ca", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P63329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63329" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P63329", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63329" } ] } ] }, { "uniprot_ac": "P63330", "gene_name": "Ppp2ca", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P63330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63330" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P63330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63330" } ] } ] }, { "uniprot_ac": "P63331", "gene_name": "Ppp2ca", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P63331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63331" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P63331", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P63331" } ] } ] }, { "uniprot_ac": "P67775", "gene_name": "PPP2CA", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P67775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67775" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P67775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P67775" } ] } ] }, { "uniprot_ac": "P97470", "gene_name": "Ppp4c", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P97470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97470" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P97470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97470" } ] } ] }, { "uniprot_ac": "P97767", "gene_name": "Eya1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "P97767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97767" } ] } ] }, { "uniprot_ac": "Q03254", "gene_name": "FCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q03254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03254" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q03254", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03254" } ] } ] }, { "uniprot_ac": "Q05547", "gene_name": "Pp1-13C", "activity": [ { 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"url": "https://www.uniprot.org/uniprot/Q05922" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05922" } ] } ] }, { "uniprot_ac": "Q05923", "gene_name": "DUSP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05923" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q05923", "database": "UniProtKB", "url": 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"url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q64623", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64623" } ] } ] }, { "uniprot_ac": "Q66GT5", "gene_name": "Ptpmt1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q66GT5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66GT5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + 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"https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "Q7KMQ6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KMQ6" } ] } ] }, { "uniprot_ac": "Q7KVM5", "gene_name": "PpN58A", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7KVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KVM5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7KVM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KVM5" } ] } ] }, { "uniprot_ac": "Q7TNL7", "gene_name": "Dusp9", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7TNL7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TNL7" } ] } ] }, { "uniprot_ac": "Q7TSG2", "gene_name": "Ctdp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7TSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSG2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7TSG2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7TSG2" } ] } ] }, { "uniprot_ac": "Q7YSW8", "gene_name": "canA", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q7YSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7YSW8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q7YSW8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7YSW8" } ] } ] }, { "uniprot_ac": "Q80TL0", "gene_name": "Ppm1e", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q80TL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TL0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q80TL0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80TL0" } ] } ] }, { "uniprot_ac": "Q80Z30", "gene_name": "Ppm1e", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q80Z30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80Z30" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q80Z30", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q80Z30" } ] } ] }, { "uniprot_ac": "Q810P3", "gene_name": "Cdkn3", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q810P3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q810P3" } ] } ] }, { "uniprot_ac": "Q86BN8", "gene_name": "PTPMT1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q86BN8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q86BN8" } ] } ] }, { "uniprot_ac": "Q8BFS6", "gene_name": "Cpped1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BFS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFS6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BFS6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFS6" } ] } ] }, { "uniprot_ac": "Q8BFV3", "gene_name": "Dusp4", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BFV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BFV3" } ] } ] }, { "uniprot_ac": "Q8BGL1", "gene_name": "Ppm1n", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BGL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGL1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BGL1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGL1" } ] } ] }, { "uniprot_ac": "Q8BGR9", "gene_name": "Ublcp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BGR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGR9" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BGR9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BGR9" } ] } ] }, { "uniprot_ac": "Q8BHN0", "gene_name": "Ppm1l", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BHN0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BHN0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BHN0" } ] } ] }, { "uniprot_ac": "Q8BK84", "gene_name": "Dusp29", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BK84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BK84" } ] } ] }, { "uniprot_ac": "Q8BTR5", "gene_name": "Dusp28", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8BTR5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BTR5" } ] } ] }, { "uniprot_ac": "Q8BU27", "gene_name": "Ppm1m", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BU27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BU27" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BU27", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BU27" } ] } ] }, { "uniprot_ac": "Q8BX07", "gene_name": "Ctdsp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BX07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX07" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BX07", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX07" } ] } ] }, { "uniprot_ac": "Q8BX10", "gene_name": "Pgam5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BX10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX10" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BX10", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BX10" } ] } ] }, { "uniprot_ac": "Q8BXA7", "gene_name": "Phlpp2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BXA7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8BXA7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BXA7" } ] } ] }, { "uniprot_ac": "Q8BXN7", "gene_name": "Ppm1k", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8BXN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BXN7" } ] }, { "ec_number": "3.1.3.52", "activity": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q8BXN7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BXN7" } ] } ] }, { "uniprot_ac": "Q8CGA0", "gene_name": "Ppm1f", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CGA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGA0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8CGA0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CGA0" } ] } ] }, { "uniprot_ac": "Q8CHE4", "gene_name": "Phlpp1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8CHE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHE4" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8CHE4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CHE4" } ] } ] }, { "uniprot_ac": "Q8IXW5", "gene_name": "RPAP2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8IXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IXW5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8IXW5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8IXW5" } ] } ] }, { "uniprot_ac": "Q8K330", "gene_name": "Ssh3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K330", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K330" } ] } ] }, { "uniprot_ac": "Q8K4T5", "gene_name": "Dusp19", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8K4T5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8K4T5" } ] } ] }, { "uniprot_ac": "Q8N3J5", "gene_name": "PPM1K", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8N3J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3J5" } ] }, { "ec_number": "3.1.3.52", "activity": "H2O + O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] = L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + phosphate.", "evidence": [ { "id": "Q8N3J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3J5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8N3J5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N3J5" } ] } ] }, { "uniprot_ac": "Q8N819", "gene_name": "PPM1N", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8N819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N819" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8N819", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8N819" } ] } ] }, { "uniprot_ac": "Q8NEJ0", "gene_name": "DUSP18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8NEJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NEJ0" } ] } ] }, { "uniprot_ac": "Q8NI37", "gene_name": "PPTC7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8NI37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NI37" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8NI37", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8NI37" } ] } ] }, { "uniprot_ac": "Q8R0F6", "gene_name": "Ilkap", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8R0F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R0F6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8R0F6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R0F6" } ] } ] }, { "uniprot_ac": "Q8R4V2", "gene_name": "Dusp15", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8R4V2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8R4V2" } ] } ] }, { "uniprot_ac": "Q8ST13", "gene_name": "", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8ST13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ST13" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8ST13", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8ST13" } ] } ] }, { "uniprot_ac": "Q8T9S7", "gene_name": "pteN", "activity": [ { "ec_number": "3.1.3.67", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] }, { "ec_number": "3.1.3.67", "activity": "", "evidence": [ { "id": "Q8T9S7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8T9S7" } ] } ] }, { "uniprot_ac": "Q8TE77", "gene_name": "SSH3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8TE77", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8TE77" } ] } ] }, { "uniprot_ac": "Q8VC34", "gene_name": "Rpap2", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VC34" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8VC34", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VC34" } ] } ] }, { "uniprot_ac": "Q8VD52", "gene_name": "Pdxp", "activity": [ { "ec_number": "3.1.3.74", "activity": "H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine.", "evidence": [ { "id": "Q8VD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD52" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD52" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "Q8VD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD52" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8VD52", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VD52" } ] } ] }, { "uniprot_ac": "Q8VE01", "gene_name": "Dusp18", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8VE01", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VE01" } ] } ] }, { "uniprot_ac": "Q8WTR2", "gene_name": "DUSP19", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WTR2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WTR2" } ] } ] }, { "uniprot_ac": "Q8WUK0", "gene_name": "PTPMT1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.27", "activity": "1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] }, { "ec_number": "3.1.3.27", "activity": "", "evidence": [ { "id": "Q8WUK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WUK0" } ] } ] }, { "uniprot_ac": "Q8WVY7", "gene_name": "UBLCP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WVY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVY7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WVY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WVY7" } ] } ] }, { "uniprot_ac": "Q8WY54", "gene_name": "PPM1E", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WY54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY54" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WY54", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WY54" } ] } ] }, { "uniprot_ac": "Q8WYL5", "gene_name": "SSH1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q8WYL5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8WYL5" } ] } ] }, { "uniprot_ac": "Q91WF7", "gene_name": "Fig4", "activity": [ { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.86", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate.", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.36", "activity": "a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate.", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.86", "activity": "", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] }, { "ec_number": "3.1.3.36", "activity": "", "evidence": [ { "id": "Q91WF7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91WF7" } ] } ] }, { "uniprot_ac": "Q91XQ2", "gene_name": "Epm2a", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.-", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q91XQ2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91XQ2" } ] } ] }, { "uniprot_ac": "Q91Z46", "gene_name": "Dusp7", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q91Z46", "database": "UniProtKB", "url": 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"uniprot_ac": "Q95TV5", "gene_name": "Dmel\\CG11597", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q95TV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95TV5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q95TV5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q95TV5" } ] } ] }, { "uniprot_ac": "Q961C5", "gene_name": "alph", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q961C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q961C5" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q961C5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q961C5" } ] } ] }, { "uniprot_ac": "Q96GD0", "gene_name": "PDXP", "activity": [ { "ec_number": "3.1.3.74", "activity": "H2O + pyridoxine 5'-phosphate = phosphate + pyridoxine.", "evidence": [ { "id": "Q96GD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GD0" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q96GD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GD0" } ] }, { "ec_number": "3.1.3.74", "activity": "", "evidence": [ { "id": "Q96GD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GD0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q96GD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96GD0" } ] } ] }, { "uniprot_ac": "Q96HS1", "gene_name": "PGAM5", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q96HS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96HS1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q96HS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96HS1" } ] } ] }, { "uniprot_ac": "Q96MI6", "gene_name": "PPM1M", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q96MI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96MI6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q96MI6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96MI6" } ] } ] }, { "uniprot_ac": "Q99502", "gene_name": "EYA1", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q99502", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99502" } ] } ] }, { "uniprot_ac": "Q99956", "gene_name": "DUSP9", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q99956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99956" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q99956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99956" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q99956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99956" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99956" } ] } ] }, { "uniprot_ac": "Q99N11", "gene_name": "Dusp22", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q99N11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q99N11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q99N11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q99N11", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99N11" } ] } ] }, { "uniprot_ac": "Q9BRF8", "gene_name": "CPPED1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BRF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BRF8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BRF8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BRF8" } ] } ] }, { "uniprot_ac": "Q9BV47", "gene_name": "DUSP26", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9BV47", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BV47" } ] } ] }, { "uniprot_ac": "Q9BVJ7", "gene_name": "DUSP23", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BVJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BVJ7" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BVJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BVJ7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BVJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BVJ7" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9BVJ7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BVJ7" } ] } ] }, { "uniprot_ac": "Q9BY84", "gene_name": "DUSP16", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9BY84", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9BY84" } ] } ] }, { "uniprot_ac": "Q9CQR6", "gene_name": "Ppp6c", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9CQR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQR6" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9CQR6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CQR6" } ] } ] }, { "uniprot_ac": "Q9CY97", "gene_name": "Ssu72", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9CY97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY97" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9CY97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9CY97" } ] } ] }, { "uniprot_ac": "Q9D0T2", "gene_name": "Dusp12", "activity": [ { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] }, { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D0T2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D0T2" } ] } ] }, { "uniprot_ac": "Q9D700", "gene_name": "Dusp26", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D700", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D700" } ] } ] }, { "uniprot_ac": "Q9D7X3", "gene_name": "Dusp3", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D7X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7X3" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D7X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7X3" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D7X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7X3" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D7X3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D7X3" } ] } ] }, { "uniprot_ac": "Q9D9D8", "gene_name": "Dusp21", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D9D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D9D8" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9D9D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D9D8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9D9D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D9D8" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9D9D8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9D9D8" } ] } ] }, { "uniprot_ac": "Q9DBB1", "gene_name": "Dusp6", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9DBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBB1" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9DBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9DBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBB1" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9DBB1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9DBB1" } ] } ] }, { "uniprot_ac": "Q9ESS0", "gene_name": "Dusp10", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9ESS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESS0" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9ESS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESS0" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9ESS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESS0" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9ESS0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9ESS0" } ] } ] }, { "uniprot_ac": "Q9GZU7", "gene_name": "CTDSP1", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9GZU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9GZU7" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9GZU7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9GZU7" } ] } ] }, { "uniprot_ac": "Q9H0C8", "gene_name": "ILKAP", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9H0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0C8" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9H0C8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H0C8" } ] } ] }, { "uniprot_ac": "Q9H1R2", "gene_name": "DUSP15", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9H1R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H1R2" } ] }, { "ec_number": "3.1.3.48", "activity": "H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate.", "evidence": [ { "id": "Q9H1R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H1R2" } ] }, { "ec_number": "3.1.3.16", "activity": "", "evidence": [ { "id": "Q9H1R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H1R2" } ] }, { "ec_number": "3.1.3.48", "activity": "", "evidence": [ { "id": "Q9H1R2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H1R2" } ] } ] }, { "uniprot_ac": "Q9H596", "gene_name": "DUSP21", "activity": [ { "ec_number": "3.1.3.16", "activity": "H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate.", "evidence": [ { "id": "Q9H596", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H596" } ] }, { "ec_number": 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