{ "uniprot_canonical_ac": "O15296-1", "uniprot_ac": "O15296", "uniprot_id": "LX15B_HUMAN", "mass": { "chemical_mass": 75857.0, "monoisotopic_mass": 75857.0 }, "refseq": { "ac": "NP_001034219", "name": "polyunsaturated fatty acid lipoxygenase ALOX15B isoform a", "summary": "This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219" }, "gene_names": [ { "name": "ALOX15B", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15296", "id": "O15296" }, { "name": "15-LOX-2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219", "id": "NP_001034219" }, { "name": "ALOX15B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219", "id": "NP_001034219" } ], "protein_names": [ { "name": "Polyunsaturated fatty acid lipoxygenase ALOX15B", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15296" }, { "name": "1.13.11.-", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "1.13.11.33", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "15-LOX-2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "15-LOX-B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "15-lipoxygenase 2", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "Arachidonate 15-lipoxygenase B", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "Arachidonate 15-lipoxygenase type II", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "Linoleate 13-lipoxygenase 15-LOb", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15296" }, { "name": "arachidonate 15-lipoxygenase, second type; arachidonate omega(6) lipoxygenase; linoleate 13-lipoxygenase 15-LOb; 15S-lipoxygenase; arachidonate 15-lipoxygenase 2; 15-LOX-B; arachidonate 15-lipoxygenase type II; polyunsaturated fatty acid lipoxygenase ALOX15B", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219", "id": "NP_001034219" }, { "name": "polyunsaturated fatty acid lipoxygenase ALOX15B isoform a", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219", "id": "NP_001034219" } ], "function": [ { "annotation": "15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection.", "evidence": [ { "database": "RefSeq", "id": "NP_001034219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219" }, { "database": "PubMed", "id": "37716021", "url": "https://glygen.org/publication/PubMed/37716021" } ] }, { "annotation": "ALOX15B expression and up-regulation in the functional and non-functional pituitary adenomas. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001034219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219" }, { "database": "PubMed", "id": "31288808", "url": "https://glygen.org/publication/PubMed/31288808" } ] }, { "annotation": "Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE.", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296#function" }, { "database": "PubMed", "id": "12704195", "url": "https://glygen.org/publication/PubMed/12704195" } ] }, { "annotation": "Low 15-LOX-2 expression is associated with lung carcinogenesis. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001034219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219" }, { "database": "PubMed", "id": "31420013", "url": "https://glygen.org/publication/PubMed/31420013" } ] }, { "annotation": "Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (PubMed:9177185, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:10542053, PubMed:24497644, PubMed:32404334) (Probable). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (PubMed:17493578, PubMed:12704195, PubMed:24282679, PubMed:9177185, PubMed:11956198, PubMed:10625675, PubMed:24497644) (Probable). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:18311922, PubMed:17493578, PubMed:11956198). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:12704195, PubMed:11839751). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809).", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296#function" }, { "database": "PubMed", "id": "22912809", "url": "https://glygen.org/publication/PubMed/22912809" }, { "database": "PubMed", "id": "18067895", "url": "https://glygen.org/publication/PubMed/18067895" }, { "database": "PubMed", "id": "10542053", "url": "https://glygen.org/publication/PubMed/10542053" }, { "database": "PubMed", "id": "9177185", "url": "https://glygen.org/publication/PubMed/9177185" }, { "database": "PubMed", "id": "10625675", "url": "https://glygen.org/publication/PubMed/10625675" }, { "database": "PubMed", "id": "27435673", "url": "https://glygen.org/publication/PubMed/27435673" }, { "database": "PubMed", "id": "12704195", "url": "https://glygen.org/publication/PubMed/12704195" }, { "database": "PubMed", "id": "27145229", "url": "https://glygen.org/publication/PubMed/27145229" }, { "database": "PubMed", "id": "32404334", "url": "https://glygen.org/publication/PubMed/32404334" }, { "database": "PubMed", "id": "18311922", "url": "https://glygen.org/publication/PubMed/18311922" }, { "database": "PubMed", "id": "11956198", "url": "https://glygen.org/publication/PubMed/11956198" }, { "database": "PubMed", "id": "11839751", "url": "https://glygen.org/publication/PubMed/11839751" }, { "database": "PubMed", "id": "17493578", "url": "https://glygen.org/publication/PubMed/17493578" }, { "database": "PubMed", "id": "24282679", "url": "https://glygen.org/publication/PubMed/24282679" }, { "database": "PubMed", "id": "16112079", "url": "https://glygen.org/publication/PubMed/16112079" }, { "database": "PubMed", "id": "24497644", "url": "https://glygen.org/publication/PubMed/24497644" } ] }, { "annotation": "This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_001034219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219" } ] }, { "annotation": "We identified a novel role for ALOX15B, and to a lesser extent ALOX15, in cholesterol homeostasis and CCL17 production in human macrophages. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_001034219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219" }, { "database": "PubMed", "id": "30197642", "url": "https://glygen.org/publication/PubMed/30197642" } ] } ], "disease": [], "snv": [], "mutagenesis": [ { "start_pos": 39, "end_pos": 39, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolishes calcium-dependent association with membranes; when associated with A-44 and A-85.", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" }, { "database": "PubMed", "id": "24497644", "url": "https://glygen.org/publication/PubMed/24497644" } ] }, { "start_pos": 44, "end_pos": 44, "sequence_org": "E", "sequence_mut": "A", "comment": "Abolishes calcium-dependent association with membranes; when associated with A-39 and A-85.", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" }, { "database": "PubMed", "id": "24497644", "url": "https://glygen.org/publication/PubMed/24497644" } ] }, { "start_pos": 602, "end_pos": 602, "sequence_org": "D", "sequence_mut": "Y", "comment": "No effect on the stereoselectivity of the oxygenation reaction. Completely changes the stereoselectivity of the oxygenation reaction to produce (8S)-HPETE instead of (15S)-HPETE; when associated with H-603.", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" }, { "database": "PubMed", "id": "10625675", "url": "https://glygen.org/publication/PubMed/10625675" } ] }, { "start_pos": 603, "end_pos": 603, "sequence_org": "V", "sequence_mut": "H", "comment": "Changes the stereoselectivity of the oxygenation reaction. Completely changes the stereoselectivity of the oxygenation reaction to produce (8S)-HPETE instead of (15S)-HPETE; when associated with Y-602.", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" }, { "database": "PubMed", "id": "10625675", "url": "https://glygen.org/publication/PubMed/10625675" } ] }, { "start_pos": 85, "end_pos": 85, "sequence_org": "D", "sequence_mut": "A", "comment": "Abolishes calcium-dependent association with membranes; when associated with A-39 and A-44.", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" }, { "database": "PubMed", "id": "24497644", "url": "https://glygen.org/publication/PubMed/24497644" } ] } ], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "57.54", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "46.21", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "60.85", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "80.79", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "56.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "47.76", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "59.83", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "61.78", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "49.99", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "92.18", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "78.41", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593" } ] } ], "expression_disease": [ { "significant": "No", "trend": "up", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O15296", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15296" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { 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"" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, 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"https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O15296", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15296" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": 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"MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "stomach cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca body - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", 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{ "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed 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cancer, male, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, protection against, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "familial cancer of the breast", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, familial Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O15296", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15296" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15296" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "up", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ { "database": "BioXpress", "id": "O15296", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15296" } ], "disease": [ { "disease_id": "DOID:3571", "recommended_name": { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "liver cancer", "description": "A hepatobiliary system cancer that is located_in the liver." }, "synonyms": [ { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Ca liver - primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "Resectable malignant neoplasm of Liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic cancer", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "hepatic neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant hepato-biliary neoplasm", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant neoplasm of liver, primary", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "malignant tumor of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": "neoplasm of liver", "description": "" }, { "id": "DOID:3571", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:3571", "name": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "common_name": "Human" } ], "gene": [ { "name": "ALOX15B", "url": "https://www.uniprot.org/uniprot/O15296", "locus": { "chromosome": "17", "start_pos": 8049134, "end_pos": 8039034, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000179593", "url": "https://www.ensembl.org/id/ENSG00000179593" } ] } } ], "crossref": [ { "id": "ENSG00000179593", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000179593", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "1.13.11.33", "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=1.13.11.33&UniProtAcc=O15296", "database": "BRENDA", "categories": [ "Enzyme and Pathway" ] }, { "id": "cd01753", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd01753", 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"https://www.ebi.ac.uk/interpro/entry/IPR001024", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001885", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001885", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013819", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013819", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020833", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020833", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020834", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020834", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036226", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036226", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036392", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036392", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR042062", "url": "https://www.ebi.ac.uk/interpro/entry/IPR042062", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:247", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:247", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "603697", "url": "http://www.omim.org/entry/603697", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O15296", "url": "https://www.nextprot.org/entry/NX_O15296", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "LHINMLA", "url": "https://omabrowser.org/oma/group/LHINMLA/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "999249at2759", "url": "http://www.orthodb.org/?query=999249at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR11771", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11771", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR11771:SF161", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11771:SF161", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "4NRE", "url": "https://www.rcsb.org/structure/4NRE", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "7LAF", "url": "https://www.rcsb.org/structure/7LAF", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF00305", "url": "http://pfam.xfam.org/family/PF00305", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF01477", "url": "http://pfam.xfam.org/family/PF01477", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O15296", "url": "https://pharos.nih.gov/targets/O15296", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O15296", "url": "http://purl.obolibrary.org/obo/PR_O15296", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-2142770", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142770", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001034219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034219", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "16869", "url": "https://www.rhea-db.org/rhea/16869", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48832", "url": "https://www.rhea-db.org/rhea/48832", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48844", "url": "https://www.rhea-db.org/rhea/48844", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "48848", "url": "https://www.rhea-db.org/rhea/48848", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50156", "url": "https://www.rhea-db.org/rhea/50156", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50180", "url": "https://www.rhea-db.org/rhea/50180", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50184", "url": "https://www.rhea-db.org/rhea/50184", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50188", "url": "https://www.rhea-db.org/rhea/50188", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "50932", "url": "https://www.rhea-db.org/rhea/50932", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53332", "url": "https://www.rhea-db.org/rhea/53332", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53652", "url": "https://www.rhea-db.org/rhea/53652", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53656", "url": "https://www.rhea-db.org/rhea/53656", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "53660", "url": "https://www.rhea-db.org/rhea/53660", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63224", "url": "https://www.rhea-db.org/rhea/63224", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63264", "url": "https://www.rhea-db.org/rhea/63264", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63268", "url": "https://www.rhea-db.org/rhea/63268", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63272", "url": "https://www.rhea-db.org/rhea/63272", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63276", "url": "https://www.rhea-db.org/rhea/63276", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63280", "url": "https://www.rhea-db.org/rhea/63280", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "63312", "url": "https://www.rhea-db.org/rhea/63312", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "64728", "url": "https://www.rhea-db.org/rhea/64728", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "I3L1D5", "url": "https://www.uniprot.org/uniprot/I3L1D5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "I3L1D5-1", "url": "https://www.uniprot.org/uniprot/I3L1D5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15296-1", "url": "https://www.uniprot.org/uniprot/O15296-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15296-2", "url": "https://www.uniprot.org/uniprot/O15296-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15296-3", "url": "https://www.uniprot.org/uniprot/O15296-3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15296-4", "url": "https://www.uniprot.org/uniprot/O15296-4", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI", "length": 676, "header": "sp|O15296-1|LX15B_HUMAN Isoform 1 of Polyunsaturated fatty acid lipoxygenase ALOX15B OS=Homo sapiens OX=9606 GN=ALOX15B PE=1 SV=3 CANONICAL=O15296-1" }, "isoforms": [ { "isoform_ac": "I3L1D5-1", "url": "", "sequence": { "sequence": "MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI", "length": 664, "header": "tr|I3L1D5-1|LX15B_HUMAN Computationally mapped isoform of Polyunsaturated fatty acid lipoxygenase ALOX15B OS=Homo sapiens OX=9606 GN=ALOX15B PE=1 SV=1 CANONICAL=O15296-1" }, "locus": { "chromosome": "17", "start_pos": 8048562, "end_pos": 8039156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000572022.5", "url": "https://www.ensembl.org/id/ENST00000572022.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000458749.1", "url": "https://www.ensembl.org/id/ENSP00000458749.1" } ] } }, { "isoform_ac": "O15296-1", "url": "", "sequence": { "sequence": "MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI", "length": 676, "header": "sp|O15296-1|LX15B_HUMAN Isoform 1 of Polyunsaturated fatty acid lipoxygenase ALOX15B OS=Homo sapiens OX=9606 GN=ALOX15B PE=1 SV=3 CANONICAL=O15296-1" }, "locus": { "chromosome": "17", "start_pos": 8048562, "end_pos": 8039156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000380183.9", "url": "https://www.ensembl.org/id/ENST00000380183.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000369530.4", "url": "https://www.ensembl.org/id/ENSP00000369530.4" } ] } }, { "isoform_ac": "O15296-2", "url": "", "sequence": { "sequence": "MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI", "length": 602, "header": "sp|O15296-2|LX15B_HUMAN Isoform 2 of Polyunsaturated fatty acid lipoxygenase ALOX15B OS=Homo sapiens OX=9606 GN=ALOX15B PE=1 SV=3 CANONICAL=O15296-1" }, "locus": { "chromosome": "17", "start_pos": 8048562, "end_pos": 8039156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000573359.1", "url": "https://www.ensembl.org/id/ENST00000573359.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000460332.2", "url": "https://www.ensembl.org/id/ENSP00000460332.2" } ] } }, { "isoform_ac": "O15296-3", "url": "", "sequence": { "sequence": "MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQVRKGQRPRWQAGGDPAPQPHSALSAFSLTPVLGCPTCHPACSCHHPPPKAWQHARAS", "length": 617, "header": "sp|O15296-3|LX15B_HUMAN Isoform 3 of Polyunsaturated fatty acid lipoxygenase ALOX15B OS=Homo sapiens OX=9606 GN=ALOX15B PE=1 SV=3 CANONICAL=O15296-1" }, "locus": {} }, { "isoform_ac": "O15296-4", "url": "", "sequence": { "sequence": "MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI", "length": 647, "header": "sp|O15296-4|LX15B_HUMAN Isoform 4 of Polyunsaturated fatty acid lipoxygenase ALOX15B OS=Homo sapiens OX=9606 GN=ALOX15B PE=1 SV=3 CANONICAL=O15296-1" }, "locus": { "chromosome": "17", "start_pos": 8048562, "end_pos": 8039156, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000380173.6", "url": "https://www.ensembl.org/id/ENST00000380173.6" }, { "database": "Ensembl Peptide", "id": "ENSP00000369520.2", "url": "https://www.ensembl.org/id/ENSP00000369520.2" } ] } } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [ "enzyme" ], "publication": [ { "title": "Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase.", "journal": "European journal of biochemistry", "date": "1999", "authors": "Kilty I, Logan A, Vickers PJ", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "10542053", "url": "https://glygen.org/publication/PubMed/10542053" } ] }, { "title": "Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2.", "journal": "The Journal of biological chemistry", "date": "2000", "authors": "Jisaka M, Kim RB, Boeglin WE, Brash AR", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "10625675", "url": "https://glygen.org/publication/PubMed/10625675" } ] }, { "title": "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.", "journal": "Genomics", "date": "2001", "authors": "Krieg P, Marks F, Furstenberger G", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "11350124", "url": "https://glygen.org/publication/PubMed/11350124" } ] }, { "title": "Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells.", "journal": "The Journal of biological chemistry", "date": "2002", "authors": "Tang S, Bhatia B, Maldonado CJ, Yang P, Newman RA, Liu J, Chandra D, Traag J, Klein RD, Fischer SM, Chopra D, Shen J, Zhau HE, Chung LW, Tang DG", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" }, { "database": "Reactome", "id": "R-HSA-2142770", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142770" } ], "reference": [ { "type": "PubMed", "id": "11839751", "url": "https://glygen.org/publication/PubMed/11839751" } ] }, { "title": "15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.", "journal": "The Journal of biological chemistry", "date": "2002-06-28", "authors": "Kozak Kevin R, Gupta Rajnish A, Moody John S, Ji Chuan, Boeglin William E, DuBois Raymond N, Brash Alan R, Marnett Lawrence J", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "11956198", "url": "https://glygen.org/publication/PubMed/11956198" } ] }, { "title": "Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants.", "journal": "The Journal of biological chemistry", "date": "2003-07-04", "authors": "Bhatia Bobby, Maldonado Carlos J, Tang Shaohua, Chandra Dhyan, Klein Russell D, Chopra Dharam, Shappell Scott B, Yang Peiying, Newman Robert A, Tang Dean G", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "12704195", "url": "https://glygen.org/publication/PubMed/12704195" } ] }, { "title": "Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist.", "journal": "Biochemical and biophysical research communications", "date": "2005-12-09", "authors": "Jisaka Mitsuo, Iwanaga Chitose, Takahashi Nobuyuki, Goto Tsuyoshi, Kawada Teruo, Yamamoto Tatsuyuki, Ikeda Izumi, Nishimura Kohji, Nagaya Tsutomu, Fushiki Tohru, Yokota Kazushige", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "16112079", "url": "https://glygen.org/publication/PubMed/16112079" } ] }, { "title": "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes.", "journal": "European journal of biochemistry", "date": "1991", "authors": "Izumi T, Radmark O, Jornvall H, Samuelsson B", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142770", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142770" } ], "reference": [ { "type": "PubMed", "id": "1662607", "url": "https://glygen.org/publication/PubMed/1662607" } ] }, { "title": "Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.", "journal": "Archives of biochemistry and biophysics", "date": "2007-08-15", "authors": "Prusakiewicz Jeffery J, Turman Melissa V, Vila Andrew, Ball Heather L, Al-Mestarihi Ahmad H, Di Marzo Vincenzo, Marnett Lawrence J", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "17493578", "url": "https://glygen.org/publication/PubMed/17493578" } ] }, { "title": "Expression of 15-lipoxygenase type-1 in human mast cells.", "journal": "Biochimica et biophysica acta", "date": "2007", "authors": "Gulliksson M, Brunnstrom A, Johannesson M, Backman L, Nilsson G, Harvima I, Dahlen B, Kumlin M, Claesson HE", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142770", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142770" } ], "reference": [ { "type": "PubMed", "id": "17662651", "url": "https://glygen.org/publication/PubMed/17662651" } ] }, { "title": "15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.", "journal": "Atherosclerosis", "date": "2008-07", "authors": "Danielsson Kristina Nor\u00e9n, Rydberg Ellen Knutsen, Ingelsten Madeleine, Aky\u00fcrek Levent M, Jirholt Pernilla, Ullstr\u00f6m Christina, Forsberg Gun-Britt, Bor\u00e9n Jan, Wiklund Olov, Hult\u00e9n Lillemor Mattsson", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "18067895", "url": "https://glygen.org/publication/PubMed/18067895" } ] }, { "title": "Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.", "journal": "Biochemistry", "date": "2008-03-25", "authors": "Turman Melissa V, Kingsley Philip J, Rouzer Carol A, Cravatt Benjamin F, Marnett Lawrence J", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "18311922", "url": "https://glygen.org/publication/PubMed/18311922" } ] }, { "title": "Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.", "journal": "Biochemistry", "date": "2008", "authors": "Wecksler AT, Kenyon V, Deschamps JD, Holman TR", "evidence": [ { "database": "Reactome", "id": "R-HSA-2142770", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2142770" } ], "reference": [ { "type": "PubMed", "id": "18570379", "url": "https://glygen.org/publication/PubMed/18570379" } ] }, { "title": "Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.", "journal": "FEBS Lett.", "date": "2008", "authors": "Yoo Hyun, Jeon Byeongwook, Jeon Myung-Shin, Lee Hyangkyu, Kim Tae-Yoon", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "18755188", "url": "https://glygen.org/publication/PubMed/18755188" } ] }, { "title": "Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.", "journal": "PloS one", "date": "2012", "authors": "Magnusson LU, Lundqvist A, Karlsson MN, Skalen K, Levin M, Wiklund O, Boren J, Hulten LM", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "reference": [ { "type": "PubMed", "id": "22912809", "url": "https://glygen.org/publication/PubMed/22912809" } ] }, { "title": "Functional characterization of genetic enzyme variations in human lipoxygenases.", "journal": "Redox 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"url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030850", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "negative regulation of cell cycle", "id": "GO:0045786", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045786", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "phospholipid metabolic process", "id": "GO:0006644", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006644", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "regulation of epithelial cell differentiation", "id": "GO:0030856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030856", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "positive regulation of peroxisome proliferator activated 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"hepoxilin biosynthetic process", "id": "GO:0051122", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051122", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "lipoxin A4 biosynthetic process", "id": "GO:2001303", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001303", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "cannabinoid biosynthetic process", "id": "GO:1901696", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901696", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 8, "go_terms": [ { "name": "iron ion binding", "id": "GO:0005506", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "id": "GO:0016702", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016702", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "calcium ion binding", "id": "GO:0005509", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "lipid binding", "id": "GO:0008289", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008289", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "linoleate 13S-lipoxygenase activity", "id": "GO:0016165", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016165", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "arachidonate 8(S)-lipoxygenase activity", "id": "GO:0036403", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036403", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "arachidonate 15-lipoxygenase activity", "id": "GO:0050473", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050473", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "linoleate 9S-lipoxygenase activity", "id": "GO:1990136", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990136", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 8, "go_terms": [ { "name": "cytosol", "id": "GO:0005829", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "nucleus", "id": "GO:0005634", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "cytoskeleton", "id": "GO:0005856", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "adherens junction", "id": "GO:0005912", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "focal adhesion", "id": "GO:0005925", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005925", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" }, { "name": "extracellular exosome", "id": "GO:0070062", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070062", "evidence": [ { "database": "UniProtKB", "id": "O15296", "url": "https://www.uniprot.org/uniprot/O15296" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 450, "end_pos": 452, "annotation": "n_glycosylation_sequon" }, { "start_pos": 598, "end_pos": 600, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [ { "id": "16869", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q02759-1", "F1LQ70-1", "Q8K4F2-1", "O15296-1", "P18054-1", "P16050-1", "P39655-1", "P39654-1" ], "evidence": [ { "id": "16869", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/16869" } ] }, { "id": "48832", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O15296-1" ], "evidence": [ { "id": "48832", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48832" } ] }, { "id": "48844", "name": "", "equation": "(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "48844", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48844" } ] }, { "id": "48848", "name": "", "equation": "(9Z,12Z)-octadecadienoate + O2 = 13-hydroperoxy-(9Z,11E)-octadecadienoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "48848", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/48848" } ] }, { "id": "50156", "name": "", "equation": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LQ70-1", "Q02759-1", "Q8K4F2-1", "P18054-1", "O15296-1", "P16050-1", "P39655-1", "P39654-1" ], "evidence": [ { "id": "50156", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50156" } ] }, { "id": "50180", "name": "", "equation": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LQ70-1", "Q02759-1", "Q8K4F2-1", "P18054-1", "O15296-1", "P16050-1", "P39655-1", "P39654-1" ], "evidence": [ { "id": "50180", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50180" } ] }, { "id": "50184", "name": "", "equation": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LQ70-1", "Q02759-1", "Q8K4F2-1", "P18054-1", "O15296-1", "P16050-1", "P39655-1", "P39654-1" ], "evidence": [ { "id": "50184", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50184" } ] }, { "id": "50188", "name": "", "equation": "N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LQ70-1", "Q02759-1", "Q8K4F2-1", "P18054-1", "O15296-1", "P16050-1", "P39655-1", "P39654-1" ], "evidence": [ { "id": "50188", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50188" } ] }, { "id": "50932", "name": "", "equation": "(8S)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + O2 = (8S,15S)-dihydroperoxy-(5Z,9E,11Z,13E)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1", "O35936-1" ], "evidence": [ { "id": "50932", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/50932" } ] }, { "id": "53332", "name": "", "equation": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "53332", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53332" } ] }, { "id": "53652", "name": "", "equation": "(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S,15S)-dihydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "53652", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53652" } ] }, { "id": "53656", "name": "", "equation": "(5S,6R)-dihydroxy-(7E,9E,11Z,14Z)-eicosatetraenoate + O2 = (5S,6R)-dihydroxy-(15S)-hydroperoxy-(7E,9E,11Z,13E)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "53656", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53656" } ] }, { "id": "53660", "name": "", "equation": "(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "53660", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/53660" } ] }, { "id": "63224", "name": "", "equation": "2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + O2 = 2-[12-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl]-glycerol", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "63224", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63224" } ] }, { "id": "63264", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphocholine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1", "O35936-1" ], "evidence": [ { "id": "63264", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63264" } ] }, { "id": "63268", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "63268", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63268" } ] }, { "id": "63272", "name": "", "equation": "1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = 1-octadecanoyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1" ], "evidence": [ { "id": "63272", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63272" } ] }, { "id": "63276", "name": "", "equation": "a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1", "O35936-1" ], "evidence": [ { "id": "63276", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63276" } ] }, { "id": "63280", "name": "", "equation": "a 1-acyl-2-(8Z,11Z,14Z-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + O2 = a 1-acyl-2-(15-hydroperoxy-8Z,11Z,13E-eicosatrienoyl)-sn-glycero-3-phospho-(1D-myo-inositol)", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1", "O35936-1" ], "evidence": [ { "id": "63280", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63280" } ] }, { "id": "63312", "name": "", "equation": "(8Z,11Z,14Z)-eicosatrienoate + O2 = 15-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q8K4F2-1", "O15296-1", "O35936-1" ], "evidence": [ { "id": "63312", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/63312" } ] }, { "id": "64728", "name": "", "equation": "(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "F1LQ70-1", "Q02759-1", "Q8K4F2-1", "O15296-1", "P18054-1", "P16050-1", "P39654-1", "P39655-1" ], "evidence": [ { "id": "64728", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/64728" } ] }, { "id": "R-HSA-2162002", "name": "Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B", "equation": "", "summary": "Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 2007, Kuhn et al. 1993, Izumi et al. 1991) and arachidonate 15-lipoxygenase B (ALOX15B) (Tang et al. 2002, Wecksler et al. 2008) are lipid peroxidising enzymes mainly expressed in airway epithelial cells, eosinophils, reticulocytes and in macrophages. They insert molecular oxygen at C-6 from the omega-end of arachidonic acid with formation of the unstable intermediate 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) which can be further converted, enzymatically or non-enzymatically, to 15S-hydroxyeicosatetraenoic acid (15S-HETE).", "cellular_location": "cytosol", "input_participant_list": [], "output_participant_list": [ "R-ALL-2142718" ], "enzyme_list": [ "O15296-1", "P16050-1" ], "evidence": [ { "id": "R-HSA-2162002", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2162002" } ] } ], "reaction_participants": [ { "participant_id": "R-ALL-2142718", "participant_name": "15S-HpETE [cytosol]", "crossref": [ { "id": "15628", "database": "ChEBI", "url": "" }, { "id": "2482", "database": "Guide to Pharmacology - Ligands", "url": "" }, { "id": "000008220105", "database": "ZINC", "url": "" }, { "id": "C05966", "database": "COMPOUND", "url": "" }, { "id": "HMDB0004244", "database": "HMDB Metabolite", "url": "" 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