{ "uniprot_canonical_ac": "O15218-1", "uniprot_ac": "O15218", "uniprot_id": "GP182_HUMAN", "mass": { "chemical_mass": 45323.0, "monoisotopic_mass": 45323.0 }, "refseq": { "ac": "NP_009195", "name": "G-protein coupled receptor 182", "summary": "Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" }, "gene_names": [ { "name": "GPR182", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15218", "id": "O15218" }, { "name": "7TMR; ADMR; AM-R; AMR; G10D; gamrh; hrhAMR; L1-R", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195", "id": "NP_009195" }, { "name": "ADMR", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15218", "id": "O15218" }, { "name": "GPR182", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195", "id": "NP_009195" }, { "name": "HBCBP", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15218", "id": "O15218" } ], "protein_names": [ { "name": "G-protein coupled receptor 182", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15218" }, { "name": "G-protein coupled receptor 182", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195", "id": "NP_009195" }, { "name": "adrenomedullin receptor", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195", "id": "NP_009195" } ], "function": [ { "annotation": "ADMR mediates the stimulatory effects of adrenomedullin on cancer cells and on endothelial and stellate cells within the tumor microenvironment Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" }, { "database": "PubMed", "id": "19847298", "url": "https://glygen.org/publication/PubMed/19847298" } ] }, { "annotation": "Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008].", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" } ] }, { "annotation": "GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" }, { "database": "PubMed", "id": "33875597", "url": "https://glygen.org/publication/PubMed/33875597" } ] }, { "annotation": "GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" }, { "database": "PubMed", "id": "35013216", "url": "https://glygen.org/publication/PubMed/35013216" } ] }, { "annotation": "Gene expression of adrenomedullin receptor components are differentially regulated in the uterus during the estrous cycle. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" }, { "database": "PubMed", "id": "23442365", "url": "https://glygen.org/publication/PubMed/23442365" } ] }, { "annotation": "Orphan receptor.", "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218#function" } ] }, { "annotation": "Our data demonstrate that GPR182 is an endothelial subtype-specific marker for human sinusoidal EC of the liver, spleen, lymph node and bone marrow. In addition, we provide evidence for GPR182-dependent downstream signaling via ERK and SRF pathways that may be involved in regulating endothelial subtype-specific sinusoidal differentiation and sinusoidal functions such as permeability.", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" }, { "database": "PubMed", "id": "29408502", "url": "https://glygen.org/publication/PubMed/29408502" } ] }, { "annotation": "This putative G protein-coupled receptor remains an orphan, as the ability to bind and be activated by adrenomedullin has been refuted. A complex of CRLR and RAMP2 or RAMP3 gives a functional adrenomedullin receptor.", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" }, { "database": "PubMed", "id": "9535752", "url": "https://glygen.org/publication/PubMed/9535752" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "rs370118515", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370118515" }, { "id": "rs370118515", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs370118515" }, { "id": "rs370118515", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs370118515#frequency_tab" }, { "id": "rs370118515", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs370118515" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 284, "end_pos": 284, "sequence_org": "H", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (HGT->NGT).", "chr_id": "12", "chr_pos": "56996059", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "H284", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs138938945", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs138938945" }, { "id": "rs138938945", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs138938945" }, { "id": "rs138938945", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs138938945" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 28, "end_pos": 28, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NWT->KWT).", "chr_id": "12", "chr_pos": "56995293", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N28", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1592446112", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1592446112" }, { "id": "rs1592446112", "database": "ENSEMBL", "url": "https://www.ensembl.org/id/rs1592446112" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 28, "end_pos": 28, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NWT->SWT).", "chr_id": "12", "chr_pos": "56995292", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N28", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "O15218", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15218" }, { "id": "rs530506452", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs530506452" }, { "id": "rs530506452", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs530506452" }, { "id": "rs530506452", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs530506452" }, { "id": "rs530506452", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs530506452" }, { "id": "rs530506452", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs530506452" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 30, "end_pos": 30, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "T", "sequence_mut": "I", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-loss (NWT->NWI).", "chr_id": "12", "chr_pos": "56995298", "ref_nt": "C", "alt_nt": "T", "minor_allelic_frequency": "", "site_lbl": "T30", "disease": [ { "disease_id": "DOID:4159", "recommended_name": { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "skin cancer", "description": "An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells." }, "synonyms": [ { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "CA - skin cancer", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "malignant neoplasm of skin", "description": "" }, { "id": "DOID:4159", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:4159", "name": "melanoma and Non-melanoma skin cancer", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "rs1362904500", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1362904500" }, { "id": "rs1362904500", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1362904500" } ], "glycoeffect": [ "n-glyco-sequon-loss", "o-glyco-site-loss" ], "start_pos": 30, "end_pos": 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"N37", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs1370229726", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1370229726" }, { "id": "rs1370229726", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs1370229726#frequency_tab" }, { "id": "rs1370229726", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1370229726" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 37, "end_pos": 37, "sequence_org": "N", "sequence_mut": "K", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NHT->KHT).", "chr_id": "12", "chr_pos": "56995320", "ref_nt": "G", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N37", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs368593597", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs368593597" }, { "id": "rs368593597", "database": "ExAC", "url": 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embryonic mesoderm." }, "synonyms": [ { "id": "DOID:1115", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1115", "name": "connective and soft tissue neoplasm", "description": "" }, { "id": "DOID:1115", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1115", "name": "tumor of soft tissue and skeleton", "description": "" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] } ], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "63.91", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "42.82", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "48.88", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "49.96", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "52.45", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": 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"namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "61.52", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "47.6", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "60.69", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "47.83", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "54.9", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856" } ] } ], "expression_disease": [ { "significant": "Yes", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O15218", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15218" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, type 1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "HPC1", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "Prca1", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "HPC11", "description": "" }, { "id": "MONDO:0012768", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012768", "name": "prostate cancer, hereditary, 11", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "HPC14", "description": "" }, { "id": "MONDO:0012769", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012769", "name": "prostate cancer, hereditary, 14", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "HPC15", "description": "" }, { "id": "MONDO:0012770", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012770", "name": "prostate cancer, hereditary, 15", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "HPCX1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer, hereditary, X-linked 1", "description": "" }, { "id": "MONDO:0010257", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010257", "name": "prostate cancer susceptibility, X-linked", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "HPCX2", "description": "" }, { "id": "MONDO:0010405", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0010405", "name": "prostate cancer, hereditary, X-linked 2", "description": "" }, { "id": "MIM:611868", "resource": "MIM", "url": "https://www.omim.org/entry/611868", "name": "Prostate cancer, hereditary, 12", "description": "Prostate cancer, hereditary, 12" }, { "id": "MIM:611928", "resource": "MIM", "url": "https://www.omim.org/entry/611928", "name": "Prostate cancer, hereditary, 13", "description": "Prostate cancer, hereditary, 13" }, { "id": "MIM:176807", "resource": "MIM", "url": "https://www.omim.org/entry/176807", "name": "Prostate cancer", "description": "Prostate cancer" }, { "id": "MIM:601518", "resource": "MIM", "url": "https://www.omim.org/entry/601518", "name": "Prostate cancer, hereditary, 1", "description": "Prostate cancer, hereditary, 1" }, { "id": "MIM:611955", "resource": "MIM", "url": "https://www.omim.org/entry/611955", "name": "Prostate cancer, hereditary, 11", "description": "Prostate cancer, hereditary, 11" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Stomach cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10534", "evidence": [ { "database": "BioXpress", "id": "O15218", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15218" } ], "disease": [ { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", 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"description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": 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}, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant neoplasm of breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "malignant tumor of the breast", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary cancer", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "mammary tumor", "description": "" }, { "id": "DOID:1612", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1612", "name": "primary breast cancer", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "hereditary breast carcinoma", "description": "Breast carcinoma that has developed in relatives of patients with history of breast carcinoma." }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer susceptibility, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, early-onset, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, invasive ductal, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": "breast cancer, lobular, somatic", "description": "" }, { "id": "MONDO:0016419", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0016419", "name": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O15218", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15218" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15218" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218" } ], "common_name": "Human" } ], "gene": [ { "name": "GPR182", "url": "https://www.uniprot.org/uniprot/O15218", "locus": { "chromosome": "12", "start_pos": 56998447, "end_pos": 56994492, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000166856", "url": "https://www.ensembl.org/id/ENSG00000166856" } ] } } ], "crossref": [ { "id": "ENSG00000166856", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000166856", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O15218", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15218", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd14988", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd14988", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL4356", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4356", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "GPR182", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR182", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "11318", "url": "https://www.ncbi.nlm.nih.gov/gene/11318", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "13708", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=13708", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O15218", "url": "https://www.ebi.ac.uk/intact/interactors/id:O15218*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000276", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001350", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001350", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017452", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR047143", "url": "https://www.ebi.ac.uk/interpro/entry/IPR047143", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:11318", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11318", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "605307", "url": "http://www.omim.org/entry/605307", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O15218", "url": "https://www.nextprot.org/entry/NX_O15218", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "LYFFNHT", "url": "https://omabrowser.org/oma/group/LYFFNHT/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "3977704at2759", "url": "http://www.orthodb.org/?query=3977704at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR24226", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24226", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24226:SF0", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24226:SF0", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PF00001", "url": "http://pfam.xfam.org/family/PF00001", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O15218", "url": "https://pharos.nih.gov/targets/O15218", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O15218", "url": "http://purl.obolibrary.org/obo/PR_O15218", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A0D9SG31", "url": 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"MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS", "length": 404, "header": "sp|O15218-1|GP182_HUMAN Isoform 1 of G-protein coupled receptor 182 OS=Homo sapiens OX=9606 GN=GPR182 PE=2 SV=1 CANONICAL=O15218-1" }, "isoforms": [ { "isoform_ac": "A0A0D9SG31-1", "url": "", "sequence": { "sequence": "XSSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS", "length": 55, "header": "tr|A0A0D9SG31-1|GP182_HUMAN Computationally mapped isoform of G-protein coupled receptor 182 OS=Homo sapiens OX=9606 GN=GPR182 PE=2 SV=1 CANONICAL=O15218-1" }, "locus": { "chromosome": "12", "start_pos": 56996423, "end_pos": 56996259, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000556850.1", "url": "https://www.ensembl.org/id/ENST00000556850.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000487111.1", "url": "https://www.ensembl.org/id/ENSP00000487111.1" } ] } }, { "isoform_ac": "O15218-1", "url": "", "sequence": { "sequence": "MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS", "length": 404, "header": "sp|O15218-1|GP182_HUMAN Isoform 1 of G-protein coupled receptor 182 OS=Homo sapiens OX=9606 GN=GPR182 PE=2 SV=1 CANONICAL=O15218-1" }, "locus": { "chromosome": "12", "start_pos": 56996421, "end_pos": 56995210, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000300098.3", "url": "https://www.ensembl.org/id/ENST00000300098.3" }, { "database": "Ensembl Peptide", "id": "ENSP00000300098.1", "url": "https://www.ensembl.org/id/ENSP00000300098.1" } ] } }, { "isoform_ac": "Q7Z4H2-1", "url": "", "sequence": { "sequence": "MISEGGWGWQGWGRSQGLRPAPCSWVSRMVSPPAAIQETQLHFLADTLPSPLSILLPPHKQEELSQSQLLIADLLPASDLGNFQTSRETQSYQKAQPTPISFSPDHRKVSRDVIPGAALGTASSRCWQMLCPSPSVPGTRWGRPQWKLLNSVTGQSSDTVISQFSLAMSFPNFPVPQLRFLNTCSTDETKKSSVNK", "length": 196, "header": "tr|Q7Z4H2-1|GP182_HUMAN Computationally mapped isoform of G-protein coupled receptor 182 OS=Homo sapiens OX=9606 GN=GPR182 PE=2 SV=1 CANONICAL=O15218-1" }, "locus": { "chromosome": "12", "start_pos": 56997548, "end_pos": 56996961, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000622922.1", "url": "https://www.ensembl.org/id/ENST00000622922.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000486086.1", "url": "https://www.ensembl.org/id/ENSP00000486086.1" } ] } } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 28, "start_aa": "Asn", "end_pos": 28, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn28", "evidence": [ { "id": "O15218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15218#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 37, "start_aa": "Asn", "end_pos": 37, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn37", "evidence": [ { "id": "O15218", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15218#ptm_processing" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "publication": [ { "title": "The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.", "journal": "PloS one", "date": "2009", "authors": "Ramachandran V, Arumugam T, Langley R, Hwang RF, Vivas-Mejia P, Sood AK, Lopez-Berestein G, Logsdon CD", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" } ], "reference": [ { "type": "PubMed", "id": "19847298", "url": "https://glygen.org/publication/PubMed/19847298" } ] }, { "title": "Intermedin in rat uterus: changes in gene expression and peptide levels across the estrous cycle and its effects on uterine contraction.", "journal": "Reproductive biology and endocrinology : RB&E", "date": "2013", "authors": "Wong CW, O WS, Tang F", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" } ], "reference": [ { "type": "PubMed", "id": "23442365", "url": "https://glygen.org/publication/PubMed/23442365" } ] }, { "title": "GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.", "journal": "Biochemical and biophysical research communications", "date": "2018", "authors": "Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Geraud C, Goerdt S, Koch PS", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" } ], "reference": [ { "type": "PubMed", "id": "29408502", "url": "https://glygen.org/publication/PubMed/29408502" } ] }, { "title": "GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2021", "authors": "Le Mercier A, Bonnavion R, Yu W, Alnouri MW, Ramas S, Zhang Y, Jager Y, Roquid KA, Jeong HW, Sivaraj KK, Cho H, Chen X, Strilic B, Sijmonsma T, Adams R, Schroeder T, Rieger MA, Offermanns S", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" } ], "reference": [ { "type": "PubMed", "id": "33875597", "url": "https://glygen.org/publication/PubMed/33875597" } ] }, { "title": "GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.", "journal": "Nature communications", "date": "2022", "authors": "Torphy RJ, Sun Y, Lin R, Caffrey-Carr A, Fujiwara Y, Ho F, Miller EN, McCarter MD, Lyons TR, Schulick RD, Kedl RM, Zhu Y", "evidence": [ { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" } ], "reference": [ { "type": "PubMed", "id": "35013216", "url": "https://glygen.org/publication/PubMed/35013216" } ] }, { "title": "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1997", "authors": "H\u00e4nze J, Dittrich K, D\u00f6tsch J, Rascher W", "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218" } ], "reference": [ { "type": "PubMed", "id": "9367907", "url": "https://glygen.org/publication/PubMed/9367907" } ] }, { "title": "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.", "journal": "Biochem. Biophys. Res. Commun.", "date": "1998", "authors": "Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ", "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218" }, { "database": "RefSeq", "id": "NP_009195", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009195" } ], "reference": [ { "type": "PubMed", "id": "9535752", "url": "https://glygen.org/publication/PubMed/9535752" } ] } ], "pathway": [ { "id": "hsa:11318", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:11318", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "P31392-1", "protein_name": "G-protein coupled receptor 182", "gene_name": "Gpr182", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIVVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPLQRICTPTPSETCRPPLCLRTPHLHSAIP", "length": 395 }, "evidence": [ { "id": "45919938", "url": "http://www.informatics.jax.org/homology/45919938", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "P43142-1", "protein_name": "G-protein coupled receptor 182", "gene_name": "Gpr182", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": 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"https://www.ebi.ac.uk/QuickGO/term/GO:0004930", "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218" } ], "pmid": "" } ] }, { "name": "Cellular Component", "total": 2, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 1, "go_terms": [ { "name": "cell surface receptor signaling pathway", "id": "GO:0007166", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007166", "evidence": [ { "database": "UniProtKB", "id": "O15218", "url": "https://www.uniprot.org/uniprot/O15218" } ], "pmid": "" } 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