{ "uniprot_canonical_ac": "O15165-1", "uniprot_ac": "O15165", "uniprot_id": "LRAD4_HUMAN", "mass": { "chemical_mass": 33900.0, "monoisotopic_mass": 33900.0 }, "refseq": { "ac": "NP_001003674", "name": "low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 1", "summary": "", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674" }, "gene_names": [ { "name": "LDLRAD4", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15165", "id": "O15165" }, { "name": "C18orf1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674", "id": "NP_001003674" }, { "name": "C18orf1", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15165", "id": "O15165" }, { "name": "LDLRAD4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674", "id": "NP_001003674" }, { "name": "hCG_37193", "resource": "UniProtKB", "type": "synonym", "url": "https://www.uniprot.org/uniprot/O15165", "id": "O15165" } ], "protein_names": [ { "name": "Low-density lipoprotein receptor class A domain-containing protein 4", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15165" }, { "name": "clone 22; low-density lipoprotein receptor class A domain-containing protein 4", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674", "id": "NP_001003674" }, { "name": "low-density lipoprotein receptor class A domain-containing protein 4 isoform gamma 1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674", "id": "NP_001003674" } ], "function": [ { "annotation": "Data suggest that C18ORF1 acts as a gatekeeper that abrogates excessive TGF-beta signaling.", "evidence": [ { "database": "RefSeq", "id": "NP_001003674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674" }, { "database": "PubMed", "id": "24627487", "url": "https://glygen.org/publication/PubMed/24627487" } ] }, { "annotation": "Depletion of LDLRAD4 in HepG2 liver cancer cells inhibited tumorigenesis in nude mice. These results reveal an oncogenic role of LDLRAD4 in tumorigenesis through its association with Nedd4.", "evidence": [ { "database": "RefSeq", "id": "NP_001003674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674" }, { "database": "PubMed", "id": "28888937", "url": "https://glygen.org/publication/PubMed/28888937" } ] }, { "annotation": "Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165#function" }, { "database": "PubMed", "id": "24627487", "url": "https://glygen.org/publication/PubMed/24627487" } ] }, { "annotation": "Identification of low-density lipoprotein receptor class A domain containing 4 (LDLRAD4) as a prognostic indicator in primary gastrointestinal stromal tumors.", "evidence": [ { "database": "RefSeq", "id": "NP_001003674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674" }, { "database": "PubMed", "id": "32507364", "url": "https://glygen.org/publication/PubMed/32507364" } ] } ], "disease": [], "snv": [], "mutagenesis": [], "expression_tissue": [ { "tissue": { "name": "Adult mammalian kidney", "namespace": "UBERON", "id": "0000082", "url": "http://purl.obolibrary.org/obo/UBERON_0000082" }, "score": "67.48", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Oral cavity", "namespace": "UBERON", "id": "0000167", "url": "http://purl.obolibrary.org/obo/UBERON_0000167" }, "score": "61.43", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Stomach", "namespace": "UBERON", "id": "0000945", "url": "http://purl.obolibrary.org/obo/UBERON_0000945" }, "score": "82.7", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Uterus", "namespace": "UBERON", "id": "0000995", "url": "http://purl.obolibrary.org/obo/UBERON_0000995" }, "score": "73", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Esophagus", "namespace": "UBERON", "id": "0001043", "url": "http://purl.obolibrary.org/obo/UBERON_0001043" }, "score": "81.54", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Rectum", "namespace": "UBERON", "id": "0001052", "url": "http://purl.obolibrary.org/obo/UBERON_0001052" }, "score": "83.63", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Colon", "namespace": "UBERON", "id": "0001155", "url": "http://purl.obolibrary.org/obo/UBERON_0001155" }, "score": "69.62", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Urinary bladder", "namespace": "UBERON", "id": "0001255", "url": "http://purl.obolibrary.org/obo/UBERON_0001255" }, "score": "78.33", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Thyroid gland", "namespace": "UBERON", "id": "0002046", "url": "http://purl.obolibrary.org/obo/UBERON_0002046" }, "score": "76.25", "present": "MEDIUM", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Lung", "namespace": "UBERON", "id": "0002048", "url": "http://purl.obolibrary.org/obo/UBERON_0002048" }, "score": "65.36", "present": "LOW", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Liver", "namespace": "UBERON", "id": "0002107", "url": "http://purl.obolibrary.org/obo/UBERON_0002107" }, "score": "89.67", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Prostate gland", "namespace": "UBERON", "id": "0002367", "url": "http://purl.obolibrary.org/obo/UBERON_0002367" }, "score": "93.75", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] }, { "tissue": { "name": "Thoracic mammary gland", "namespace": "UBERON", "id": "0005200", "url": "http://purl.obolibrary.org/obo/UBERON_0005200" }, "score": "87.27", "present": "HIGH", "evidence": [ { "database": "Bgee", "id": "ENSG00000168675", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168675" } ] } ], "expression_disease": [ { "significant": "No", "trend": "down", "name": "Prostate cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:10283", "evidence": [ { "database": "BioXpress", "id": "O15165", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15165" } ], "disease": [ { "disease_id": "DOID:10283", "recommended_name": { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer", "description": "A male reproductive organ cancer that is located_in the prostate." }, "synonyms": [ { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10283", "name": "tumor of the prostate", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "prostate cancer, hereditary, type 9", "description": "" }, { "id": "MONDO:0012597", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012597", "name": "HPC9", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the EHBP1 gene." }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "EHBP1 familial prostate cancer", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "familial prostate cancer caused by mutation in EHBP1", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "prostate cancer, hereditary, type 12", "description": "" }, { "id": "MONDO:0012741", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012741", "name": "HPC12", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "prostate cancer, hereditary, type 5", "description": "" }, { "id": "MONDO:0012244", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012244", "name": "HPC5", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, hereditary, type 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "prostate cancer, susceptibility to, 3", "description": "" }, { "id": "MONDO:0012093", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012093", "name": "HPC3", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, type 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, susceptibility to, 4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "HPC4", "description": "" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, type 13", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "HPC13", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, hereditary, type 8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "HPC8", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "predisposing for prostate cancer", "description": "" }, { "id": "MONDO:0011270", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011270", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, hereditary, type 6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "HPC6", "description": "" }, { "id": "MONDO:0012300", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012300", "name": "prostate cancer, susceptibility to", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "HPC10", "description": "" }, { "id": "MONDO:0012620", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012620", "name": "prostate cancer, hereditary, 10", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate carcinoma", "description": "Prostate carcinoma that has developed in relatives of patients with a history of prostate carcinoma." }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "familial prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate cancer", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "hereditary prostate carcinoma", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, somatic", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, familial", "description": "" }, { "id": "MONDO:0023122", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0023122", "name": "prostate cancer, hereditary", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "HPC7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer, hereditary, 7", "description": "" }, { "id": "MONDO:0012470", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012470", "name": "prostate cancer aggressiveness", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "prostate cancer, hereditary, 1", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene." }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "RNASEL familial prostate cancer", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0011098", "name": "familial prostate cancer caused by mutation in RNASEL", "description": "" }, { "id": "MONDO:0011098", "resource": "MONDO", "url": 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"O15165-7", "url": "https://www.uniprot.org/uniprot/O15165-7", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15165-8", "url": "https://www.uniprot.org/uniprot/O15165-8", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 306, "header": "sp|O15165-1|LRAD4_HUMAN Isoform 1 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "isoforms": [ { "isoform_ac": "A0A7I2V2E6-1", "url": "", "sequence": { "sequence": "MVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 211, "header": "tr|A0A7I2V2E6-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13645654, "end_pos": 13621167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000678400.1", "url": "https://www.ensembl.org/id/ENST00000678400.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000502869.1", "url": "https://www.ensembl.org/id/ENSP00000502869.1" } ] } }, { "isoform_ac": "A0A7I2V2Z9-1", "url": "", "sequence": { "sequence": "MSSDHLNNSTLKEAQFKDLFLKKVTHLLQHHELQRRRRGM", "length": 40, "header": "tr|A0A7I2V2Z9-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13615810, "end_pos": 13612705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000678556.1", "url": "https://www.ensembl.org/id/ENST00000678556.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000503182.1", "url": "https://www.ensembl.org/id/ENSP00000503182.1" } ] } }, { "isoform_ac": "A0A7I2V3Q9-1", "url": "", "sequence": { "sequence": "MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFN", "length": 60, "header": "tr|A0A7I2V3Q9-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13438384, "end_pos": 13387723, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000677304.1", "url": "https://www.ensembl.org/id/ENST00000677304.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000503549.1", "url": "https://www.ensembl.org/id/ENSP00000503549.1" } ] } }, { "isoform_ac": "A0A7I2V3W1-1", "url": "", "sequence": { "sequence": "MSSDHLNNSTLKEAQFKDLFLKKAELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEVLSSRAGRDLRKQAALSCPRKL", "length": 115, "header": "tr|A0A7I2V3W1-1|A0A7I2V3W1_HUMAN Computationally mapped isoform of Low density lipoprotein receptor class A domain containing 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13644710, "end_pos": 13612705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000676773.1", "url": "https://www.ensembl.org/id/ENST00000676773.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000503617.1", "url": "https://www.ensembl.org/id/ENSP00000503617.1" } ] } }, { "isoform_ac": "A0A7I2V3Z2-1", "url": "", "sequence": { "sequence": "MSSDHLNNSTLKEAQFKDLFLKKGTFPKNCYG", "length": 32, "header": "tr|A0A7I2V3Z2-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13612800, "end_pos": 13612705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000590308.1", "url": "https://www.ensembl.org/id/ENST00000590308.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000503712.1", "url": "https://www.ensembl.org/id/ENSP00000503712.1" } ] } }, { "isoform_ac": "A0A7I2V575-1", "url": "", "sequence": { "sequence": "MPEAGFQATNAFTAELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 259, "header": "tr|A0A7I2V575-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13645654, "end_pos": 13387723, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000677055.1", "url": "https://www.ensembl.org/id/ENST00000677055.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504396.1", "url": "https://www.ensembl.org/id/ENSP00000504396.1" } ] } }, { "isoform_ac": "A0A7I2YQI3-1", "url": "", "sequence": { "sequence": "MVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQ", "length": 35, "header": "tr|A0A7I2YQI3-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13621271, "end_pos": 13621167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000678309.1", "url": "https://www.ensembl.org/id/ENST00000678309.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000503755.1", "url": "https://www.ensembl.org/id/ENSP00000503755.1" } ] } }, { "isoform_ac": "K7EJM9-1", "url": "", "sequence": { "sequence": "MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQ", "length": 112, "header": "tr|K7EJM9-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=2 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13621271, "end_pos": 13387723, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000676891.1", "url": "https://www.ensembl.org/id/ENST00000676891.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000503092.1", "url": "https://www.ensembl.org/id/ENSP00000503092.1" } ] } }, { "isoform_ac": "K7EMG1-1", "url": "", "sequence": { "sequence": "MVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLP", "length": 34, "header": "tr|K7EMG1-1|LRAD4_HUMAN Computationally mapped isoform of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13621268, "end_pos": 13621167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000593236.1", "url": "https://www.ensembl.org/id/ENST00000593236.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000466490.1", "url": "https://www.ensembl.org/id/ENSP00000466490.1" } ] } }, { "isoform_ac": "O15165-1", "url": "", "sequence": { "sequence": "MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 306, "header": "sp|O15165-1|LRAD4_HUMAN Isoform 1 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13645654, "end_pos": 13387723, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000359446.11", "url": "https://www.ensembl.org/id/ENST00000359446.11" }, { "database": "Ensembl Peptide", "id": "ENSP00000352420.5", "url": "https://www.ensembl.org/id/ENSP00000352420.5" } ] } }, { "isoform_ac": "O15165-2", "url": "", "sequence": { "sequence": "MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 288, "header": "sp|O15165-2|LRAD4_HUMAN Isoform 2 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13645654, "end_pos": 13387723, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000399848.7", "url": "https://www.ensembl.org/id/ENST00000399848.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000382741.2", "url": "https://www.ensembl.org/id/ENSP00000382741.2" } ] } }, { "isoform_ac": "O15165-3", "url": "", "sequence": { "sequence": "MAAELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 248, "header": "sp|O15165-3|LRAD4_HUMAN Isoform 3 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": {} }, { "isoform_ac": "O15165-4", "url": "", "sequence": { "sequence": "MAAELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 230, "header": "sp|O15165-4|LRAD4_HUMAN Isoform 4 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": {} }, { "isoform_ac": "O15165-5", "url": "", "sequence": { "sequence": "MVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 229, "header": "sp|O15165-5|LRAD4_HUMAN Isoform 5 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13645654, "end_pos": 13621167, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000677744.1", "url": "https://www.ensembl.org/id/ENST00000677744.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000504022.1", "url": "https://www.ensembl.org/id/ENSP00000504022.1" } ] } }, { "isoform_ac": "O15165-6", "url": "", "sequence": { "sequence": "MSSDHLNNSTLKEAQFKDLFLKKAELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 269, "header": "sp|O15165-6|LRAD4_HUMAN Isoform 6 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13645654, "end_pos": 13612705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000587757.5", "url": "https://www.ensembl.org/id/ENST00000587757.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000466178.1", "url": "https://www.ensembl.org/id/ENSP00000466178.1" } ] } }, { "isoform_ac": "O15165-7", "url": "", "sequence": { "sequence": "MSSDHLNNSTLKEAQFKDLFLKKAELEFAQIIIIVVVVTVMVVVIVCLLNHYKVSTRSFINRPNQSRRREDGLPQIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 251, "header": "sp|O15165-7|LRAD4_HUMAN Isoform 7 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": { "chromosome": "18", "start_pos": 13645654, "end_pos": 13612705, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000586765.1", "url": "https://www.ensembl.org/id/ENST00000586765.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000474783.1", "url": "https://www.ensembl.org/id/ENSP00000474783.1" } ] } }, { "isoform_ac": "O15165-8", "url": "", "sequence": { "sequence": "MRLDSHLECISSTQEGCLWPSDSAAPRLGASEIMHAPRSRDRFTAPSFIQRDRFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDIAMYSGGPCPPSSNSGISASTCSSNGRMEGPPPTYSEVMGHHPGASFLHHQRSNAHRGSRLQFQQNNAESTIVPIKGKDRKPGNLV", "length": 208, "header": "sp|O15165-8|LRAD4_HUMAN Isoform 8 of Low-density lipoprotein receptor class A domain-containing protein 4 OS=Homo sapiens OX=9606 GN=LDLRAD4 PE=1 SV=1 CANONICAL=O15165-1" }, "locus": {} } ], "glycosylation": [], "phosphorylation": [], "glycation": [], "keywords": [], "publication": [ { "title": "Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia.", "journal": "J. Hum. Genet.", "date": "2009", "authors": "Meerabux JM, Ohba H, Iwayama Y, Maekawa M, Detera-Wadleigh SD, DeLisi LE, Yoshikawa T", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" } ], "reference": [ { "type": "PubMed", "id": "19461657", "url": "https://glygen.org/publication/PubMed/19461657" } ] }, { "title": "C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.", "journal": "The Journal of biological chemistry", "date": "2014", "authors": "Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" }, { "database": "RefSeq", "id": "NP_001003674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674" } ], "reference": [ { "type": "PubMed", "id": "24627487", "url": "https://glygen.org/publication/PubMed/24627487" } ] }, { "title": "Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells.", "journal": "Experimental cell research", "date": "2017", "authors": "Liu Z, Huo X, Zhao S, Yang J, Shi W, Jing L, Li W, Li Y, Ma L, Gao Y, Diao A", "evidence": [ { "database": "RefSeq", "id": "NP_001003674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674" } ], "reference": [ { "type": "PubMed", "id": "28888937", "url": "https://glygen.org/publication/PubMed/28888937" } ] }, { "title": "Identification of low-density lipoprotein receptor class A domain containing 4 (LDLRAD4) as a prognostic indicator in primary gastrointestinal stromal tumors.", "journal": "Current problems in cancer", "date": "2020", "authors": "Xie W, Xiao H, Luo J, Zhao L, Jin F, Ma J, Li J, Xiong K, Chen C, Wang G", "evidence": [ { "database": "RefSeq", "id": "NP_001003674", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003674" } ], "reference": [ { "type": "PubMed", "id": "32507364", "url": "https://glygen.org/publication/PubMed/32507364" } ] }, { "title": "Multiple transcriptional variants and RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains on 18p11.2.", "journal": "Genomics", "date": "1998", "authors": "Yoshikawa T, Sanders AR, Esterling LE, Detera-Wadleigh SD", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" } ], "reference": [ { "type": "PubMed", "id": "9479497", "url": "https://glygen.org/publication/PubMed/9479497" } ] } ], "pathway": [ { "id": "hsa:753", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:753", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "A0A8I5ZUC8-1", "protein_name": "Low density lipoprotein receptor class A domain containing 4", "gene_name": "Ldlrad4", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQVLIIVVVVTVMVVVVVCLLNHYKVSTRSFINRPNQSQRQEDGLQPEGSLWPSDSSVQRPGASEIMCAPRGRDRFTTPSFIQRDPFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTIFDSDLIDISMYNGGPCPPSSHSGISAATCSSNGRMEGPPPTYSEVMGHYPGTSFFHHQHSNAHRGSRQQFQPNNSEGTIVPIKGKDRKPGDLV", "length": 306 }, "evidence": [ { "id": "45922725", "url": "http://www.informatics.jax.org/homology/45922725", "database": "MGI" }, { "id": "O15165", "url": "https://omabrowser.org/oma/group/O15165/", "database": "OMA" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BWJ4-1", "protein_name": "Low-density lipoprotein receptor class A domain-containing protein 4", "gene_name": "Ldlrad4", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MPEAGFQATNAFTECKFTCTSGKCLYLGSLVCNQQNDCGDNSDEENCLLVTEHPPPGIFNSELEFAQILIIVVVVTVMVVVVVCLLNHYKVSTRSFINRPNQSQRQEDGLQPEGSLWPSDSSVQRPGASEIMCAPRGRDRFTTPSFIQRDPFSRFQPTYPYVQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQMELNRESVRAPPNRTVFDSDLIDISMYNGGPCPPSSHSGISAATCSSNGRMEGPPPTYSEVMGHYPGTSFFHHQHSNTHRGSRPQFQPNNSEGTIVPIKGKDRKPGDLV", "length": 306 }, "evidence": [ { "id": "45922725", "url": "http://www.informatics.jax.org/homology/45922725", "database": "MGI" }, { "id": "O15165", "url": "https://omabrowser.org/oma/group/O15165/", "database": "OMA" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 4, "go_terms": [ { "name": "intracellular membrane-bounded organelle", "id": "GO:0043231", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" } ], "pmid": "" }, { "name": "early endosome membrane", "id": "GO:0031901", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031901", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" } ], "pmid": "" }, { "name": "Golgi membrane", "id": "GO:0000139", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" } ], "pmid": "" }, { "name": "membrane", "id": "GO:0016020", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 4, "go_terms": [ { "name": "negative regulation of transforming growth factor beta receptor signaling pathway", "id": "GO:0030512", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030512", "evidence": [ { "database": "UniProtKB", "id": "O15165", "url": "https://www.uniprot.org/uniprot/O15165" } ], "pmid": "" }, { "name": "negative 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