{ "uniprot_canonical_ac": "O15146-1", "uniprot_ac": "O15146", "uniprot_id": "MUSK_HUMAN", "mass": { "chemical_mass": 97056.0, "monoisotopic_mass": 97056.0 }, "refseq": { "ac": "NP_001159752", "name": "muscle, skeletal receptor tyrosine-protein kinase isoform 2", "summary": "This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009].", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752" }, "gene_names": [ { "name": "MUSK", "resource": "UniProtKB", "type": "recommended", "url": "https://www.uniprot.org/uniprot/O15146", "id": "O15146" }, { "name": "CMS9; FADS; FADS1", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752", "id": "NP_001159752" }, { "name": "MUSK", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752", "id": "NP_001159752" } ], "protein_names": [ { "name": "Muscle, skeletal receptor tyrosine-protein kinase", "resource": "UniProtKB", "type": "recommended", "url": "", "id": "O15146" }, { "name": "2.7.10.1", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15146" }, { "name": "MuSK", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15146" }, { "name": "Muscle-specific kinase receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15146" }, { "name": "Muscle-specific tyrosine-protein kinase receptor", "resource": "UniProtKB", "type": "synonym", "url": "", "id": "O15146" }, { "name": "muscle, skeletal receptor tyrosine-protein kinase isoform 2", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752", "id": "NP_001159752" }, { "name": "muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor; muscle, skeletal, receptor tyrosine kinase", "resource": "RefSeq", "type": "synonym", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752", "id": "NP_001159752" } ], "function": [ { "annotation": "A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells.", "evidence": [ { "database": "RefSeq", "id": "NP_001159752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752" }, { "database": "PubMed", "id": "36579833", "url": "https://glygen.org/publication/PubMed/36579833" } ] }, { "annotation": "Missense mutation does not affect MuSK catalytic kinase activity but diminishes expression and stability.", "evidence": [ { "database": "RefSeq", "id": "NP_001159752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752" }, { "database": "PubMed", "id": "15496425", "url": "https://glygen.org/publication/PubMed/15496425" } ] }, { "annotation": "Proteolytic ectodomain shedding of muscle-specific tyrosine kinase in myasthenia gravis.", "evidence": [ { "database": "RefSeq", "id": "NP_001159752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752" }, { "database": "PubMed", "id": "36525997", "url": "https://glygen.org/publication/PubMed/36525997" } ] }, { "annotation": "Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146#function" }, { "database": "PubMed", "id": "25537362", "url": "https://glygen.org/publication/PubMed/25537362" } ] }, { "annotation": "The collagen ColQ binds to LRP4 and regulates the activation of the Muscle-Specific Kinase-LRP4 receptor complex by agrin at the neuromuscular junction.", "evidence": [ { "database": "RefSeq", "id": "NP_001159752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752" }, { "database": "PubMed", "id": "37356721", "url": "https://glygen.org/publication/PubMed/37356721" } ] }, { "annotation": "This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009].", "evidence": [ { "database": "RefSeq", "id": "NP_001159752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752" } ] } ], "disease": [ { "disease_id": "DOID:0110670", "recommended_name": { "id": "DOID:0110670", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110670", "name": "congenital myasthenic syndrome 9", "description": "A congenital myasthenic syndrome characterized by autosomal recessive inheritance of defects in postsynaptic neuromuscular junctions, reduced miniature endplate potential amplitude, proximal muscle weakness and episodic respiratory insufficiency that has_material_basis_in homozygous or compound heterozygous mutation in the MUSK gene on chromosome 9q31." }, "synonyms": [ { "id": "DOID:0110670", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110670", "name": "congenital myasthenic syndrome 9, associated with acetylcholine receptor deficiency", "description": "" }, { "id": "DOID:0110670", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110670", "name": "CMS9", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome 9", "description": "Any congenital myasthenic syndrome in which the cause of the disease is a mutation in the MUSK gene." }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "CMS9", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "MUSK congenital myasthenic syndrome", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome 9, associated with acetylcholine receptor deficiency", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome caused by mutation in MUSK", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome type 9", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency", "description": "" }, { "id": "MIM:616325", "resource": "MIM", "url": "https://www.omim.org/entry/616325", "name": "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency", "description": "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency" } ], "evidence": [ { "id": "616325", "database": "MIM", "url": "https://www.omim.org/entry/616325" } ] }, { "disease_id": "DOID:0111375", "recommended_name": { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia deformation sequence syndrome", "description": "A syndrome characterized by decreased fetal movements, intrauterine growth restriction, joint contractures, and developmental anomalies, including lung hypoplasia, cleft palate, and cryptorchidism that often has_material_basis_in mutation in a gene associated with the neuromuscular junction." }, "synonyms": [ { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "arthrogryposis multiplex congenita-pulmonary hypoplasia syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "FADS", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia sequence", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia deformation sequence syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia sequence", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "fetal akinesia deformation sequence 1", "description": "Any fetal akinesia deformation sequence in which the cause of the disease is a mutation in the MUSK gene." }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome, type 1", "description": "" }, { "id": "MIM:208150", "resource": "MIM", "url": "https://www.omim.org/entry/208150", "name": "Fetal akinesia deformation sequence 1", "description": "Fetal akinesia deformation sequence 1" } ], "evidence": [ { "id": "208150", "database": "MIM", "url": "https://www.omim.org/entry/208150" } ] }, { "disease_id": "DOID:0111377", "recommended_name": { "id": "DOID:0111377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111377", "name": "fetal akinesia deformation sequence syndrome 1", "description": "A fetal akinesia deformation 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"name": "Pena-Shokeir syndrome, type 1", "description": "" }, { "id": "MIM:208150", "resource": "MIM", "url": "https://www.omim.org/entry/208150", "name": "Fetal akinesia deformation sequence 1", "description": "Fetal akinesia deformation sequence 1" } ], "evidence": [ { "id": "208150", "database": "MIM", "url": "https://www.omim.org/entry/208150" } ] } ], "snv": [ { "evidence": [ { "id": "rs1276383503", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs1276383503" }, { "id": "rs1276383503", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs1276383503" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 104, "end_pos": 104, "sequence_org": "G", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (NNG->NNS).", "chr_id": "9", "chr_pos": "110687220", "ref_nt": "A", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "G104", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs772324297", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772324297" }, { "id": "rs772324297", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs772324297" }, { "id": "rs772324297", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs772324297" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 193, "end_pos": 193, "sequence_org": "K", "sequence_mut": "N", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-gain (KNS->NNS).", "chr_id": "9", "chr_pos": "110697417", "ref_nt": "C", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "K193", "keywords": [ "ebi", "germline" ] }, { "evidence": [ { "id": "rs55826142", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs55826142" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 222, "end_pos": 222, "sequence_org": "N", "sequence_mut": "I", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->IVT).", "chr_id": "9", "chr_pos": "110734287", "ref_nt": "T", "alt_nt": "null", "minor_allelic_frequency": "", "site_lbl": "N222", "disease": [ { "disease_id": "DOID:0110670", "recommended_name": { "id": "DOID:0110670", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110670", "name": "congenital myasthenic syndrome 9", "description": "A congenital myasthenic syndrome characterized by autosomal recessive inheritance of defects in postsynaptic neuromuscular junctions, reduced miniature endplate potential amplitude, proximal muscle weakness and episodic respiratory insufficiency that has_material_basis_in homozygous or compound heterozygous mutation in the MUSK gene on chromosome 9q31." }, "synonyms": [ { "id": "DOID:0110670", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110670", "name": "congenital myasthenic 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acetylcholine receptor deficiency", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome caused by mutation in MUSK", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome type 9", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency", "description": "" }, { "id": "MIM:616325", "resource": "MIM", "url": "https://www.omim.org/entry/616325", "name": "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency", "description": "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency" } ] }, { "disease_id": "DOID:0111375", "recommended_name": { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia deformation sequence syndrome", "description": "A syndrome characterized by decreased fetal movements, intrauterine growth restriction, joint contractures, and developmental anomalies, including lung hypoplasia, cleft palate, and cryptorchidism that often has_material_basis_in mutation in a gene associated with the neuromuscular junction." }, "synonyms": [ { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "arthrogryposis multiplex congenita-pulmonary hypoplasia syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "FADS", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia sequence", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia deformation sequence syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia sequence", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "fetal akinesia deformation sequence 1", "description": "Any fetal akinesia deformation sequence in which the cause of the disease is a mutation in the MUSK gene." }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome, type 1", "description": "" }, { "id": "MIM:208150", "resource": "MIM", "url": "https://www.omim.org/entry/208150", "name": "Fetal akinesia deformation sequence 1", "description": "Fetal akinesia deformation sequence 1" } ] }, { "disease_id": "DOID:0111377", "recommended_name": { "id": "DOID:0111377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111377", "name": "fetal akinesia deformation sequence syndrome 1", "description": "A fetal akinesia deformation sequence that has_material_basis_in homozygous or compound heterozygous mutation in the MUSK gene on chromosome 9q31.3." }, "synonyms": [ { "id": "DOID:0111377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111377", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "fetal akinesia deformation sequence 1", "description": "Any fetal akinesia deformation sequence in which the cause of the disease is a mutation in the MUSK gene." }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome, type 1", "description": "" }, { "id": "MIM:208150", "resource": "MIM", "url": "https://www.omim.org/entry/208150", "name": "Fetal akinesia deformation sequence 1", "description": "Fetal akinesia deformation sequence 1" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "rs55826142", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs55826142" }, { "id": "rs55826142", "database": "1000Genomes", "url": "https://www.ensembl.org/homo_sapiens/Variation/Explore?v=rs55826142" }, { "id": "rs55826142", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs55826142" }, { "id": "rs55826142", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs55826142#frequency_tab" }, { "id": "rs55826142", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs55826142" } ], "glycoeffect": [ "n-glyco-sequon-loss" ], "start_pos": 222, "end_pos": 222, "sequence_org": "N", "sequence_mut": "S", "comment": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NVT->SVT).", "chr_id": "9", "chr_pos": 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"https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15146" } ], "glycoeffect": [], "start_pos": 413, "end_pos": 413, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "M", "sequence_mut": "I", "comment": "Somatic mutation passed 1 out of 6 filters: num. of cancers (3).", "chr_id": "9", "chr_pos": "110775842", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "M413", "disease": [ { "disease_id": "DOID:2531", "recommended_name": { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "hematologic cancer", "description": "An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes." }, "synonyms": [ { "id": "DOID:2531", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:2531", "name": "Hematologic malignancy", "description": "" }, { "id": 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deficiency", "description": "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency" } ] }, { "disease_id": "DOID:0111375", "recommended_name": { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia deformation sequence syndrome", "description": "A syndrome characterized by decreased fetal movements, intrauterine growth restriction, joint contractures, and developmental anomalies, including lung hypoplasia, cleft palate, and cryptorchidism that often has_material_basis_in mutation in a gene associated with the neuromuscular junction." }, "synonyms": [ { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "arthrogryposis multiplex congenita-pulmonary hypoplasia syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "FADS", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia sequence", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia deformation sequence syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia sequence", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "fetal akinesia deformation sequence 1", "description": "Any fetal akinesia deformation sequence in which the cause of the disease is a mutation in the 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homozygous or compound heterozygous mutation in the MUSK gene on chromosome 9q31.3." }, "synonyms": [ { "id": "DOID:0111377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111377", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "fetal akinesia deformation sequence 1", "description": "Any fetal akinesia deformation sequence in which the cause of the disease is a mutation in the MUSK gene." }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome, type 1", "description": "" }, { "id": "MIM:208150", "resource": "MIM", "url": "https://www.omim.org/entry/208150", "name": "Fetal akinesia deformation sequence 1", "description": "Fetal akinesia deformation sequence 1" } ] } ], "keywords": [ "ebi", "germline", "disease" ] }, { "evidence": [ { "id": "O15146", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15146" }, { "id": "rs199507468", "database": "dbSNP", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199507468" }, { "id": "rs199507468", "database": "ExAC", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199507468" }, { "id": "rs199507468", "database": "NCI-TCGA", "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs199507468" }, { "id": "rs199507468", "database": "TOPMed", "url": "https://www.ncbi.nlm.nih.gov/snp/rs199507468#frequency_tab" }, { "id": "rs199507468", "database": "gnomAD", "url": "http://gnomad.broadinstitute.org/awesome?query=rs199507468" } ], "glycoeffect": [ "n-glyco-sequon-gain" ], "start_pos": 763, "end_pos": 763, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "A", "sequence_mut": "T", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (NDA->NDT).", "chr_id": "9", "chr_pos": "110800665", "ref_nt": "G", "alt_nt": "A", "minor_allelic_frequency": "", "site_lbl": "A763", "disease": [ { "disease_id": "DOID:363", "recommended_name": { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine cancer", "description": "A female reproductive organ cancer that is located_in the uterus." }, "synonyms": [ { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "CA - cancer of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "Tumour of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "malignant uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "neoplasm of uterus", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterine tumor", "description": "" }, { "id": "DOID:363", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:363", "name": "uterus neoplasm", "description": "" } ] }, { "disease_id": "DOID:10534", "recommended_name": { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "stomach cancer", "description": "A gastrointestinal system cancer that is located_in the stomach." }, "synonyms": [ { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric cancer", "description": "" }, { "id": "DOID:10534", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:10534", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "A primary or metastatic malignant neoplasm involving the stomach." }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "Ca lesser curvature - stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "cancer of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer risk after h. pylori infection", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, somatic", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumor", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant gastric tumour", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant stomach neoplasm", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of greater curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of lesser curve of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumor of the stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant tumour of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant 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"https://monarchinitiative.org/disease/MONDO:0001056", "name": "ca greater curvature of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "malignant neoplasm of body of stomach", "description": "" }, { "id": "MONDO:0001056", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001056", "name": "gastric cancer, intestinal", "description": "" }, { "id": "MIM:613659", "resource": "MIM", "url": "https://www.omim.org/entry/613659", "name": "Gastric cancer", "description": "Gastric cancer" } ] }, { "disease_id": "DOID:0110670", "recommended_name": { "id": "DOID:0110670", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0110670", "name": "congenital myasthenic syndrome 9", "description": "A congenital myasthenic syndrome characterized by autosomal recessive inheritance of defects in postsynaptic neuromuscular junctions, reduced miniature endplate 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"" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "MUSK congenital myasthenic syndrome", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome 9, associated with acetylcholine receptor deficiency", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome caused by mutation in MUSK", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "congenital myasthenic syndrome type 9", "description": "" }, { "id": "MONDO:0014587", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0014587", "name": "myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency", "description": "" }, { "id": "MIM:616325", "resource": "MIM", "url": "https://www.omim.org/entry/616325", "name": "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency", "description": "Myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency" } ] }, { "disease_id": "DOID:0111375", "recommended_name": { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia deformation sequence syndrome", "description": "A syndrome characterized by decreased fetal movements, intrauterine growth restriction, joint contractures, and developmental anomalies, including lung hypoplasia, cleft palate, and cryptorchidism that often has_material_basis_in mutation in a gene associated with the neuromuscular junction." }, "synonyms": [ { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "arthrogryposis multiplex congenita-pulmonary hypoplasia syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "FADS", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "fetal akinesia sequence", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia deformation sequence syndrome", "description": "" }, { "id": "DOID:0111375", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111375", "name": "foetal akinesia sequence", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "fetal akinesia deformation sequence 1", "description": "Any fetal akinesia deformation sequence in which the cause of the disease is a mutation in the MUSK gene." }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome, type 1", "description": "" }, { "id": "MIM:208150", "resource": "MIM", "url": "https://www.omim.org/entry/208150", "name": "Fetal akinesia deformation sequence 1", "description": "Fetal akinesia deformation sequence 1" } ] }, { "disease_id": "DOID:0111377", "recommended_name": { "id": "DOID:0111377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111377", "name": "fetal akinesia deformation sequence syndrome 1", "description": "A fetal akinesia deformation sequence that has_material_basis_in homozygous or compound heterozygous mutation in the MUSK gene on chromosome 9q31.3." }, "synonyms": [ { "id": "DOID:0111377", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:0111377", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "fetal akinesia deformation sequence 1", "description": "Any fetal akinesia deformation sequence in which the cause of the disease is a mutation in the MUSK gene." }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "FADS1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome type 1", "description": "" }, { "id": "MONDO:0100101", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0100101", "name": "Pena-Shokeir syndrome, type 1", "description": "" }, { "id": "MIM:208150", "resource": "MIM", "url": "https://www.omim.org/entry/208150", "name": "Fetal akinesia deformation sequence 1", "description": "Fetal akinesia deformation sequence 1" } ] } ], "keywords": [ "biomuta", "somatic", "cancer", "disease", "ebi", "germline" ] }, { "evidence": [ { "id": "O15146", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15146" } ], "glycoeffect": [ "n-glyco-sequon-gain", "o-glyco-site-loss" ], "start_pos": 848, "end_pos": 848, "subjects_tested": "0", "subjects_positive": "0", "frequency": "0.0", "sequence_org": "S", "sequence_mut": "N", "comment": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (SFT->NFT).", 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"" }, { "id": "MONDO:0012094", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012094", "name": "prostate cancer, hereditary, on chromosome 7", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "Any familial prostate cancer in which the cause of the disease is a mutation in the MSMB gene." }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "MSMB familial prostate cancer", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "familial prostate cancer caused by mutation in MSMB", "description": "" }, { "id": "MONDO:0012758", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0012758", "name": "prostate cancer, hereditary, 13", "description": "" }, { "id": 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Male", "description": "" }, { "id": "MIM:114480", "resource": "MIM", "url": "https://www.omim.org/entry/114480", "name": "Breast cancer", "description": "Breast cancer" } ] } ] }, { "significant": "Yes", "trend": "down", "name": "Thyroid cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:1781", "evidence": [ { "database": "BioXpress", "id": "O15146", "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15146" } ], "disease": [ { "disease_id": "DOID:1781", "recommended_name": { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." }, "synonyms": [ { "id": "DOID:1781", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:1781", "name": "thyroid gland cancer", "description": "" }, { "id": "DOID:1781", "resource": "Disease Ontology", 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"https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/O15146" } ], "disease": [ { "disease_id": "DOID:263", "recommended_name": { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "kidney cancer", "description": "A urinary system cancer that is located_in the kidney." }, "synonyms": [ { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant neoplasm of kidney except pelvis", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "malignant tumour of kidney", "description": "" }, { "id": "DOID:263", "resource": "Disease Ontology", "url": "http://disease-ontology.org/term/DOID:263", "name": "renal cancer", "description": "" } ] } ] }, { "significant": "No", "trend": "down", "name": "Liver cancer [DO disease name]", "url": "http://disease-ontology.org/term/DOID:3571", "evidence": [ 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large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of colorectum", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant neoplasm of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumor of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large bowel", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant tumour of the large intestine", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "CRC", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, susceptibility to, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "large intestine cancer", "description": "" }, { "id": "MIM:114500", "resource": "MIM", "url": "https://www.omim.org/entry/114500", "name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "common_name": "Human" } ], "gene": [ { "name": "MUSK", "url": "https://www.uniprot.org/uniprot/O15146", "locus": { "chromosome": "9", "start_pos": 110806558, "end_pos": 110668779, "strand": "-", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000030304", "url": "https://www.ensembl.org/id/ENSG00000030304" } ] } } ], "crossref": [ { "id": "ENSG00000030304", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000030304", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O15146", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15146", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "cd05050", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05050", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20968", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20968", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "cd20970", "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd20970", "database": "CDD", "categories": [ "Protein Classification" ] }, { "id": "CHEMBL5684", "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL5684", "database": "ChEMBL", "categories": [ "Other" ] }, { "id": "MUSK", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=MUSK", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "4593", "url": "https://www.ncbi.nlm.nih.gov/gene/4593", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "7525", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=7525", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O15146", "url": "https://www.ebi.ac.uk/intact/interactors/id:O15146*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR000719", "url": "https://www.ebi.ac.uk/interpro/entry/IPR000719", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR001245", "url": "https://www.ebi.ac.uk/interpro/entry/IPR001245", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003598", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003598", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR003599", "url": "https://www.ebi.ac.uk/interpro/entry/IPR003599", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR007110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR008266", "url": "https://www.ebi.ac.uk/interpro/entry/IPR008266", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011009", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011009", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013098", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013098", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR013783", "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR017441", "url": "https://www.ebi.ac.uk/interpro/entry/IPR017441", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020067", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020067", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR020635", "url": "https://www.ebi.ac.uk/interpro/entry/IPR020635", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036179", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036790", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036790", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR043204", "url": "https://www.ebi.ac.uk/interpro/entry/IPR043204", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:4593", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:4593", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "208150", "url": "http://www.omim.org/entry/208150", "database": "MIM", "categories": [ "Other" ] }, { "id": "601296", "url": "http://www.omim.org/entry/601296", "database": "MIM", "categories": [ "Other" ] }, { "id": "616325", "url": "http://www.omim.org/entry/616325", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O15146", "url": "https://www.nextprot.org/entry/NX_O15146", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O15146", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15146", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "GQFYQGW", "url": "https://omabrowser.org/oma/group/GQFYQGW/", "database": "OMA", "categories": [ "Protein Classification" ] }, { "id": "1614410at2759", "url": "http://www.orthodb.org/?query=1614410at2759", "database": "OrthoDB", "categories": [ "Protein Classification" ] }, { "id": "PTHR10075", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10075", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24416", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "PTHR24416:SF317", "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24416:SF317", "database": "PANTHER", "categories": [ "Protein Classification" ] }, { "id": "8S9P", "url": "https://www.rcsb.org/structure/8S9P", "database": "PDB", "categories": [ "3D Structure" ] }, { "id": "PF01392", "url": "http://pfam.xfam.org/family/PF01392", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07679", "url": "http://pfam.xfam.org/family/PF07679", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF07714", "url": "http://pfam.xfam.org/family/PF07714", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "PF13927", "url": "http://pfam.xfam.org/family/PF13927", "database": "Pfam", "categories": [ "Protein Classification" ] }, { "id": "O15146", "url": "https://pharos.nih.gov/targets/O15146", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O15146", "url": "http://purl.obolibrary.org/obo/PR_O15146", "database": "PRO", "categories": [ "Protein" ] }, { "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178", "database": "Reactome", "categories": [ "Protein Classification" ] }, { "id": "NP_001159752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "10596", "url": "https://www.rhea-db.org/rhea/10596", "database": "Rhea", "categories": [ "Enzyme and Pathway" ] }, { "id": "A0A087WSY1", "url": "https://www.uniprot.org/uniprot/A0A087WSY1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A087WSY1-1", "url": "https://www.uniprot.org/uniprot/A0A087WSY1-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6XAJ2", "url": "https://www.uniprot.org/uniprot/F6XAJ2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "F6XAJ2-1", "url": "https://www.uniprot.org/uniprot/F6XAJ2-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15146-1", "url": "https://www.uniprot.org/uniprot/O15146-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15146-2", "url": "https://www.uniprot.org/uniprot/O15146-2", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15146-3", "url": "https://www.uniprot.org/uniprot/O15146-3", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": "MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV", "length": 869, "header": "sp|O15146-1|MUSK_HUMAN Isoform 1 of Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=MUSK PE=1 SV=1 CANONICAL=O15146-1" }, "isoforms": [ { "isoform_ac": "A0A087WSY1-1", "url": "", "sequence": { "sequence": "MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLAFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV", "length": 861, "header": "tr|A0A087WSY1-1|MUSK_HUMAN Computationally mapped isoform of Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=MUSK PE=1 SV=1 CANONICAL=O15146-1" }, "locus": { "chromosome": "9", "start_pos": 110800985, "end_pos": 110668905, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000416899.7", "url": "https://www.ensembl.org/id/ENST00000416899.7" }, { "database": "Ensembl Peptide", "id": "ENSP00000393608.3", "url": "https://www.ensembl.org/id/ENSP00000393608.3" } ] } }, { "isoform_ac": "F6XAJ2-1", "url": "", "sequence": { "sequence": "NGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEGAKGIHTQFVASALQLRSFLSCPQI", "length": 132, "header": "tr|F6XAJ2-1|MUSK_HUMAN Computationally mapped isoform of Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=MUSK PE=1 SV=2 CANONICAL=O15146-1" }, "locus": { "chromosome": "9", "start_pos": 110706149, "end_pos": 110687217, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374439.1", "url": "https://www.ensembl.org/id/ENST00000374439.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000363562.2", "url": "https://www.ensembl.org/id/ENSP00000363562.2" } ] } }, { "isoform_ac": "O15146-1", "url": "", "sequence": { "sequence": "MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV", "length": 869, "header": "sp|O15146-1|MUSK_HUMAN Isoform 1 of Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=MUSK PE=1 SV=1 CANONICAL=O15146-1" }, "locus": { "chromosome": "9", "start_pos": 110800985, "end_pos": 110668905, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000374448.9", "url": "https://www.ensembl.org/id/ENST00000374448.9" }, { "database": "Ensembl Peptide", "id": "ENSP00000363571.4", "url": "https://www.ensembl.org/id/ENSP00000363571.4" } ] } }, { "isoform_ac": "O15146-2", "url": "", "sequence": { "sequence": "MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEEESEPEQDTKVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLAFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV", "length": 783, "header": "sp|O15146-2|MUSK_HUMAN Isoform 2 of Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=MUSK PE=1 SV=1 CANONICAL=O15146-1" }, "locus": { "chromosome": "9", "start_pos": 110800985, "end_pos": 110668905, "strand": "-", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000189978.10", "url": "https://www.ensembl.org/id/ENST00000189978.10" }, { "database": "Ensembl Peptide", "id": "ENSP00000189978.6", "url": "https://www.ensembl.org/id/ENSP00000189978.6" } ] } }, { "isoform_ac": "O15146-3", "url": "", "sequence": { "sequence": "MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLAFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV", "length": 773, "header": "sp|O15146-3|MUSK_HUMAN Isoform 3 of Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens OX=9606 GN=MUSK PE=1 SV=1 CANONICAL=O15146-1" }, "locus": {} } ], "glycosylation": [ { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 222, "start_aa": "Asn", "end_pos": 222, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn222", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146#ptm_processing" } ] }, { "glytoucan_ac": "", "type": "N-linked", "subtype": "", "site_category": "predicted", "site_seq": "N", "relation": "attached", "comment": "N-linked (GlcNAc...) asparagine", "start_pos": 338, "start_aa": "Asn", "end_pos": 338, "end_aa": "Asn", "residue": "Asn", "site_lbl": "Asn338", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146#ptm_processing" } ] }, { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O15146", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15146" }, { "id": "28411811", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/28411811" } ] } ], "phosphorylation": [ { "start_pos": 554, "end_pos": 554, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by autocatalysis", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" }, { "database": "iPTMnet", "id": "O15146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15146" }, { "database": "PubMed", "id": "10781064", "url": "https://glygen.org/publication/PubMed/10781064" }, { "database": "PubMed", "id": "16794080", "url": "https://glygen.org/publication/PubMed/16794080" }, { "database": "PubMed", "id": "19244212", "url": "https://glygen.org/publication/PubMed/19244212" } ], "site_lbl": "Tyr554" }, { "start_pos": 681, "end_pos": 681, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" }, { "database": "iPTMnet", "id": "O15146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15146" }, { "database": "PubMed", "id": "16818610", "url": "https://glygen.org/publication/PubMed/16818610" } ], "site_lbl": "Ser681" }, { "start_pos": 698, "end_pos": 698, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Ser", "comment": "Phosphoserine; by CK2", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" }, { "database": "iPTMnet", "id": "O15146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15146" }, { "database": "PubMed", "id": "16818610", "url": "https://glygen.org/publication/PubMed/16818610" } ], "site_lbl": "Ser698" }, { "start_pos": 755, "end_pos": 755, "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "", "residue": "Tyr", "comment": "Phosphotyrosine; by autocatalysis", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "site_lbl": "Tyr755" } ], "glycation": [], "keywords": [ "enzyme", "glycoprotein", "glycoprotein_predicted", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Binding of the G domains of laminin alpha1 and alpha2 chains and perlecan to heparin, sulfatides, alpha-dystroglycan and several extracellular matrix proteins.", "journal": "The EMBO journal", "date": "1999", "authors": "Talts JF, Andac Z, Gohring W, Brancaccio A, Timpl R", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "10022829", "url": "https://glygen.org/publication/PubMed/10022829" } ] }, { "title": "Agrin in Alzheimer's disease: altered solubility and abnormal distribution within microvasculature and brain parenchyma.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "1999", "authors": "Donahue JE, Berzin TM, Rafii MS, Glass DJ, Yancopoulos GD, Fallon JR, Stopa EG", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "10339611", "url": "https://glygen.org/publication/PubMed/10339611" } ] }, { "title": "Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain.", "journal": "Molecular and cellular neurosciences", "date": "2000", "authors": "Cotman SL, Halfter W, Cole GJ", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "10673326", "url": "https://glygen.org/publication/PubMed/10673326" } ] }, { "title": "The in vitro and in vivo phosphotyrosine map of activated MuSK.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2000", "authors": "Watty A, Neubauer G, Dreger M, Zimmer M, Wilm M, Burden SJ", "evidence": [ { "database": "iPTMnet", "id": "O15146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15146" } ], "reference": [ { "type": "PubMed", "id": "10781064", "url": "https://glygen.org/publication/PubMed/10781064" } ] }, { "title": "Mutations in cartilage oligomeric matrix protein causing pseudoachondroplasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Thur J, Rosenberg K, Nitsche DP, Pihlajamaa T, Ala-Kokko L, Heinegard D, Paulsson M, Maurer P", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "11084047", "url": "https://glygen.org/publication/PubMed/11084047" } ] }, { "title": "Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helix.", "journal": "The Journal of biological chemistry", "date": "2001", "authors": "Wiberg C, Hedbom E, Khairullina A, Lamande SR, Oldberg A, Timpl R, Morgelin M, Heinegard D", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "11259413", "url": "https://glygen.org/publication/PubMed/11259413" } ] }, { "title": "Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin.", "journal": "Matrix biology : journal of the International Society for Matrix Biology", "date": "2002", "authors": "Di Cesare PE, Chen FS, Moergelin M, Carlson CS, Leslie MP, Perris R, Fang C", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "12225811", "url": "https://glygen.org/publication/PubMed/12225811" } ] }, { "title": "Mapping of binding sites for heparin, plasminogen activator inhibitor-1, and plasminogen to vitronectin's heparin-binding region reveals a novel vitronectin-dependent feedback mechanism for the control of plasmin formation.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Kost C, Stuber W, Ehrlich HJ, Pannekoek H, Preissner KT", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "1376317", "url": "https://glygen.org/publication/PubMed/1376317" } ] }, { "title": "Neurite outgrowth by the alternatively spliced region of human tenascin-C is mediated by neuronal alpha7beta1 integrin.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "date": "2004", "authors": "Mercado ML, Nur-e-Kamal A, Liu HY, Gross SR, Movahed R, Meiners S", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "14715956", "url": "https://glygen.org/publication/PubMed/14715956" } ] }, { "title": "Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias.", "journal": "The Journal of biological chemistry", "date": "2004", "authors": "Mann HH, Ozbek S, Engel J, Paulsson M, Wagener R", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "15075323", "url": "https://glygen.org/publication/PubMed/15075323" } ] }, { "title": "Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins.", "journal": "Structure (London, England : 1993)", "date": "2004", "authors": "Lundell A, Olin AI, Morgelin M, al-Karadaghi S, Aspberg A, Logan DT", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "15296743", "url": "https://glygen.org/publication/PubMed/15296743" } ] }, { "title": "Binding of the proteoglycan decorin to collagen type VI.", "journal": "The Journal of biological chemistry", "date": "1992", "authors": "Bidanset DJ, Guidry C, Rosenberg LC, Choi HU, Timpl R, Hook M", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "1544908", "url": "https://glygen.org/publication/PubMed/1544908" } ] }, { "title": "MUSK, a new target for mutations causing congenital myasthenic syndrome.", "journal": "Human molecular genetics", "date": "2004", "authors": "Chevessier F, Faraut B, Ravel-Chapuis A, Richard P, Gaudon K, Bauche S, Prioleau C, Herbst R, Goillot E, Ioos C, Azulay JP, Attarian S, Leroy JP, Fournier E, Legay C, Schaeffer L, Koenig J, Fardeau M, Eymard B, Pouget J, Hantai D", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" }, { "database": "RefSeq", "id": "NP_001159752", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159752" } ], "reference": [ { "type": "PubMed", "id": "15496425", "url": "https://glygen.org/publication/PubMed/15496425" } ] }, { "title": "Interactions between collagen IX and biglycan measured by atomic force microscopy.", "journal": "Biochemical and biophysical research communications", "date": "2006", "authors": "Chen CH, Yeh ML, Geyer M, Wang GJ, Huang MH, Heggeness MH, Hook M, Luo ZP", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "16293224", "url": "https://glygen.org/publication/PubMed/16293224" } ] }, { "title": "Involvement of tenascin-C and PG-M/versican in flexor tenosynovial pathology of idiopathic carpal tunnel syndrome.", "journal": "Histology and histopathology", "date": "2006", "authors": "Tsujii M, Hirata H, Yoshida T, Imanaka-Yoshida K, Morita A, Uchida A", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "16493581", "url": "https://glygen.org/publication/PubMed/16493581" } ] }, { "title": "The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.", "journal": "Science (New York, N.Y.)", "date": "2006", "authors": "Okada K, Inoue A, Okada M, Murata Y, Kakuta S, Jigami T, Kubo S, Shiraishi H, Eguchi K, Motomura M, Akiyama T, Iwakura Y, Higuchi O, Yamanashi Y", "evidence": [ { "database": "iPTMnet", "id": "O15146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15146" } ], "reference": [ { "type": "PubMed", "id": "16794080", "url": "https://glygen.org/publication/PubMed/16794080" } ] }, { "title": "Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction.", "journal": "Genes & development", "date": "2006", "authors": "Cheusova T, Khan MA, Schubert SW, Gavin AC, Buchou T, Jacob G, Sticht H, Allende J, Boldyreff B, Brenner HR, Hashemolhosseini S", "evidence": [ { "database": "iPTMnet", "id": "O15146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15146" } ], "reference": [ { "type": "PubMed", "id": "16818610", "url": "https://glygen.org/publication/PubMed/16818610" } ] }, { "title": "Patterns of somatic mutation in human cancer genomes.", "journal": "Nature", "date": "2007", "authors": "Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "reference": [ { "type": "PubMed", "id": "17344846", "url": "https://glygen.org/publication/PubMed/17344846" } ] }, { "title": "Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan.", "journal": "The Journal of biological chemistry", "date": "2007", "authors": "Chen FH, Herndon ME, Patel N, Hecht JT, Tuan RS, Lawler J", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "17588949", "url": "https://glygen.org/publication/PubMed/17588949" } ] }, { "title": "Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation.", "journal": "Science signaling", "date": "2009", "authors": "Inoue A, Setoguchi K, Matsubara Y, Okada K, Sato N, Iwakura Y, Higuchi O, Yamanashi Y", "evidence": [ { "database": "iPTMnet", "id": "O15146", "url": "http://research.bioinformatics.udel.edu/iptmnet/entry/O15146" } ], "reference": [ { "type": "PubMed", "id": "19244212", "url": "https://glygen.org/publication/PubMed/19244212" } ] }, { "title": "Refinement of the clinical phenotype in musk-related congenital myasthenic syndromes.", "journal": "Neurology", "date": "2009", "authors": "Mihaylova V, Salih MA, Mukhtar MM, Abuzeid HA, El-Sadig SM, von der Hagen M, Huebner A, Nurnberg G, Abicht A, Muller JS, Lochmuller H, Guergueltcheva V", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "reference": [ { "type": "PubMed", "id": "19949040", "url": "https://glygen.org/publication/PubMed/19949040" } ] }, { "title": "Mutations in MUSK causing congenital myasthenic syndrome impair MuSK-Dok-7 interaction.", "journal": "Human molecular genetics", "date": "2010", "authors": "Maselli RA, Arredondo J, Cagney O, Ng JJ, Anderson JA, Williams C, Gerke BJ, Soliven B, Wollmann RL", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "reference": [ { "type": "PubMed", "id": "20371544", "url": "https://glygen.org/publication/PubMed/20371544" } ] }, { "title": "Decorin interacts with fibrillar collagen of embryonic and adult human skin.", "journal": "Journal of structural biology", "date": "1991", "authors": "Fleischmajer R, Fisher LW, MacDonald ED, Jacobs L Jr, Perlish JS, Termine JD", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "2059554", "url": "https://glygen.org/publication/PubMed/2059554" } ] }, { "title": "Development and validation of a method for profiling post-translational modification activities using protein microarrays.", "journal": "PloS one", "date": "2010", "authors": "Del Rincon SV, Rogers J, Widschwendter M, Sun D, Sieburg HB, Spruck C", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "reference": [ { "type": "PubMed", "id": "20596523", "url": "https://glygen.org/publication/PubMed/20596523" } ] }, { "title": "The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.", "journal": "Mol. Cell", "date": "2010", "authors": "Bergamin E, Hallock PT, Burden SJ, Hubbard SR", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "reference": [ { "type": "PubMed", "id": "20603078", "url": "https://glygen.org/publication/PubMed/20603078" } ] }, { "title": "Dentin matrix protein 1 (DMP1) signals via cell surface integrin.", "journal": "The Journal of biological chemistry", "date": "2011", "authors": "Wu H, Teng PN, Jayaraman T, Onishi S, Li J, Bannon L, Huang H, Close J, Sfeir C", "evidence": [ { "database": "Reactome", "id": "R-HSA-3000178", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-3000178" } ], "reference": [ { "type": "PubMed", "id": "21642437", "url": "https://glygen.org/publication/PubMed/21642437" } ] }, { "title": "Collagen I and III and their decorin modified surfaces studied by atomic force microscopy and the elucidation of their affinity toward positive apolipoprotein B-100 residue by quartz crystal 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} ], "common_name": "Rat" } ], "go_annotation": { "categories": [ { "name": "Cellular Component", "total": 5, "go_terms": [ { "name": "plasma membrane", "id": "GO:0005886", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "neuromuscular junction", "id": "GO:0031594", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031594", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "receptor complex", "id": "GO:0043235", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "postsynaptic membrane", "id": "GO:0045211", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045211", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "synapse", "id": "GO:0045202", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" } ] }, { "name": "Biological Process", "total": 14, "go_terms": [ { "name": "cell adhesion", "id": "GO:0007155", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "axon guidance", "id": "GO:0007411", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007411", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "positive regulation of protein phosphorylation", "id": "GO:0001934", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001934", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase signaling pathway", "id": "GO:0007169", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007169", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "neuromuscular junction development", "id": "GO:0007528", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007528", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "memory", "id": "GO:0007613", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007613", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "positive regulation of gene expression", "id": "GO:0010628", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010628", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "positive regulation of neuron projection development", "id": "GO:0010976", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010976", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "cell differentiation", "id": "GO:0030154", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "id": "GO:0051897", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051897", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "protein autophosphorylation", "id": "GO:0046777", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046777", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "positive regulation of protein geranylgeranylation", "id": "GO:2000541", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000541", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "regulation of synaptic assembly at neuromuscular junction", "id": "GO:0008582", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008582", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "skeletal muscle acetylcholine-gated channel clustering", "id": "GO:0071340", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071340", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" } ] }, { "name": "Molecular Function", "total": 5, "go_terms": [ { "name": "protein tyrosine kinase activity", "id": "GO:0004713", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004713", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "metal ion binding", "id": "GO:0046872", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "Wnt-protein binding", "id": "GO:0017147", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017147", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" }, { "name": "transmembrane receptor protein tyrosine kinase activity", "id": "GO:0004714", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004714", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 222, "end_pos": 224, "annotation": "n_glycosylation_sequon" }, { "start_pos": 338, "end_pos": 340, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [ { "annotation": "Neddylated.", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" }, { "database": "PubMed", "id": "20596523", "url": "https://glygen.org/publication/PubMed/20596523" } ] }, { "annotation": "Phosphorylated (By similarity). Phosphorylation is induced by AGRIN in a LRP4-dependent manner (By similarity). Autophosphorylated (PubMed:25029443). Autophosphorylation at Tyr-554 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (By similarity).", "evidence": [ { "database": "UniProtKB", "id": "O15146", "url": "https://www.uniprot.org/uniprot/O15146" }, { "database": "PubMed", "id": "25029443", "url": "https://glygen.org/publication/PubMed/25029443" } ] } ], "interactions": [], "reactions": [ { "id": "10596", "name": "", "equation": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]", "summary": "", "cellular_location": "", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "Q9WUD9-1", "P57760-1", "P35739-1", "F1LYY7-1", "A0A8I6GCV6-1", "Q63132-1", "Q63117-1", "Q5U2X5-1", "Q63474-1", "Q4V8A3-1", "O08680-1", "O35346-1", "P54757-1", "P54758-1", "P54759-1", "P70600-1", "Q00495-1", "Q03351-1", "Q04589-1", "P06494-1", "P09759-1", "P29321-1", "P32577-1", "Q6XUX2-1", "Q62662-1", "Q62799-1", "Q62844-1", "Q62956-1", "Q63184-1", "Q63470-1", "Q498D6-1", "Q01621-1", "Q6P6U0-1", "Q63604-1", "P09760-1", "Q01986-1", "Q62862-1", "Q63572-1", "Q07014-1", "Q4KSH7-1", "G3V9H8-1", "P15127-1", "O08775-1", "P53767-1", "Q05030-1", "P55146-1", "Q64725-1", "Q63802-1", "Q64716-1", "P09215-1", "Q62689-1", "F1LM93-1", "P36506-1", "P20786-1", "P24062-1", "Q924U5-1", "Q63272-1", "B2RYC7-1", "P41243-1", "M0RDA4-1", "Q62838-1", "Q63116-1", "A0A8I6AM23-1", "P50545-1", "P57097-1", "P97523-1", "Q91ZT1-1", "D4A7W7-1", "F1LVI0-1", "E9PSY0-1", "A0A0G2K6M9-1", "F1LSN4-1", "F1MAJ0-1", "A0A0R4J8U1-1", "A0A8I6A5T6-1", "D3ZDS3-1", "D4ADZ5-1", "F1LSG7-1", "F1LRZ0-1", "D3ZBN3-1", "F1M0N1-1", "G3V6K6-1", "D3ZD03-1", "D3ZZK3-1", "E9PT20-1", "D4A584-1", "D3ZDH4-1", "A0A8I5ZVE3-1", "A0A8I6AWX7-1", "Q4KM97-1", "Q501W1-1", "B5DFD6-1", "Q5FVG7-1", "D3ZCD0-1", "A0A8I5ZP97-1", "A0A0G2JW59-1", "B1WC09-1", "Q01134-1", "P11980-1", "G3V783-1", "D3ZJI4-1", "Q4KSH6-1", "M0R7E7-1", "Q925D6-1", "Q9UM73-1", "O15146-1", "P42679-1", "P08922-1", "P07947-1", "Q12866-1", "P00519-1", "Q07912-1", "P42684-1", "Q9UF33-1", "P10721-1", "P08069-1", "P06239-1", "P04626-1", "P51451-1", "Q06187-1", "P51813-1", "Q9UIG0-1", "P49760-1", "P49761-4", "Q9HAZ1-1", "P49759-1", "P07333-1", "Q5JZY3-1", "Q6XUX3-1", "P00533-1", "Q9Y463-1", "P29317-1", "Q9NR20-1", "Q13627-1", "P54760-1", "P41240-1", "Q16832-1", "Q15375-1", "P29323-1", "P22455-1", "P16591-1", "P29322-1", "P54756-1", "P29320-1", "Q08345-1", "Q92630-1", "P54753-1", "Q15303-1", "P21860-1", "Q14289-1", "O43781-1", "P54764-1", "P19525-1", "P21709-1", "P54762-1", "P22607-1", "P21802-1", "P52333-1", "P11362-1", "P42685-1", "P06213-1", "P14616-1", "Q05655-1", "Q08881-1", "P07332-1", "P08631-1", "P29376-1", "Q05397-1", "O60674-1", "P23458-1", "P36888-1", "P09769-1", "P06241-1", "P43405-1", "P07948-1", "P46734-1", "P45985-1", "Q02750-1", "P52564-1", "O14733-1", "Q13163-1", "Q16288-1", "P36507-1", "Q16620-1", "P08581-1", "P04629-1", "Q14680-1", "Q01974-1", "P09619-1", "P07949-1", "Q504Y2-1", "P34925-1", "P16234-1", "Q13882-1", "Q04912-1", "O43353-1", "Q06418-1", "P30530-1", "Q96KB5-1", "Q15569-1", "Q96S53-1", "Q6J9G0-1", "P42680-1", "P35916-2", "P0C1S8-1", "P17948-1", "P29597-1", "P42681-1", "P35590-1", "Q13470-1", "P33981-1", "P30291-1", "P12931-1", "P35968-1", "P43403-1", "O75716-1", "Q02763-1", "Q9H3Y6-1", "P35790-1", "P14618-1", "P24604-1", "Q9Z188-1", "P35969-1", "P52332-1", "P08923-1", "Q00342-1", "Q62120-1", "Q4JIM5-1", "P97504-1", "P42682-1", "Q60629-1", "O54967-1", "P00520-1", "P97793-1", "P16277-1", "O35491-1", "O35492-1", "O35493-1", "Q9Z277-1", "P35991-1", "P22518-1", "Q8BYG9-1", "P54754-1", "P54761-1", "Q6XUX1-1", "Q62371-1", "Q60750-1", "Q61527-1", "Q62413-1", "Q61214-1", "Q61772-1", "Q61851-1", "Q922Y0-1", "Q922K9-1", "O09127-1", "P16092-1", "Q03142-1", "P29319-1", "Q01279-1", "P70424-1", "P21803-1", "Q8CBF3-1", "P41241-1", "Q03963-1", "Q8BI55-1", "P54763-3", "P16879-1", "P09581-1", "P34152-3", "P14234-1", "P39688-1", "Q03146-1", "Q03145-1", "Q61526-1", "P70451-1", "Q5U4C9-1", "Q9QVP9-1", "Q03137-1", "Q60751-1", "Q62137-1", "P28867-1", "P25911-1", "P48025-1", "Q9WTL4-1", "P41242-1", "P05532-1", "P06240-1", "P08103-1", "P15208-1", "Q03526-1", "Q9WVS7-1", "P70236-1", "P31938-1", "P47809-1", "Q61846-1", "Q60805-1", "Q63932-1", "O09110-1", "P26618-1", "Q8CE90-1", "P16056-1", "P05622-1", "P15209-1", "Q6VNS1-1", "Q61006-1", "Q3UFB7-1", "Q5RJI4-1", "Q9JJ78-1", "P58801-1", "Q8VCT9-1", "O70146-1", "Q62190-1", "Q62270-1", "P35546-1", "P35761-1", "Q9Z138-1", "Q9R117-1", "O88697-1", "P05480-2", "Q01887-1", "Q02858-1", "Q06806-1", "Q00993-1", "Q64434-1", "Q6J9G1-1", "Q99ML2-1", "Q78DX7-1", "P55144-1", "P43404-1", "P35917-1", "P47810-1", "P35918-1", "Q04736-1", "Q66JT0-1", "O54804-1", "P52480-1", "P14680-1", "P21965-1", "P22216-1", "P32490-1", "P06784-1", "P08018-1", "P32350-1", "P32491-1", "P54199-1", "Q54G28-1", "Q54N73-1", "Q54R58-1", "P18160-1", "P18161-1", "Q54BC9-1", "Q54I36-1", "Q54QV3-1", "Q552C6-1", "Q55CL6-1", "Q75JK0-1", "Q76NV1-1", "Q23977-1", "P18475-1", "P13368-1", "Q24145-1", "Q24488-1", "Q27324-1", "P08630-1", "P00522-1", "P00528-1", "P04412-1", "Q9V422-1", "Q9V6K3-1", "Q9V9J3-1", "Q9VBW3-1", "P09208-1", "P49762-1", "P83102-1", "Q24324-1", "Q9VPC0-1", "P49657-1", "P54350-1", "P18106-4", "Q07407-1", "Q09147-1", "Q24592-1", "Q9I7F7-1", "Q9V3D5-1", "Q9VZI2-1", "Q8INJ8-1", "Q7KJ08-1", "Q9VJ04-1", "E1JHB7-1", "Q9VE06-1", "O61444-1", "O62602-1", "Q9VZA8-1", "Q7KT06-1" ], "evidence": [ { "id": "10596", "database": "Rhea", "url": "https://www.rhea-db.org/rhea/10596" } ] }, { "id": "R-HSA-2467633", "name": "AGRN binds LRP4:MUSK", "equation": "", "summary": "Agrin (AGRN) is a large multidomain heparan sulfate proteoglycan found in basement membranes, named for its ability to promote aggregation of AChR clusters on the muscle surface directly beneath the nerve terminal (Nitkin et al. 1987). It is a critical organizer of postsynaptic differentiation at the skeletal neuromuscular junction; synaptogenesis is profoundly disrupted in its absence (Gautam et al. 1996). Two alternate N termini exist with differential expression, tissue localization and function. The predominant longer LN form (Burgess et al. 2000) starts with a secretion signal sequence and a laminin-binding domain (Denzer et al. 1995, Kammerer et al. 1999); the shorter SN form associates with the plasma membrane (Burgess et al. 2000, Neumann et al. 2001). Following the SN or LN regions are 8 follistatin repeats, known to bind growth factors and inhibit proteases in other proteins. The central region has two repeats homologous to domain III of laminin. The C-terminal portion, which is responsible for the molecule's known signaling functions, contains four EGF repeats and three LG (G) domains homologous to those found in laminin alpha chains, neurexins and slits (Timpl et al. 2000).


AGRN binds a complex of the tyrosine kinase receptor MuSK, which is responsible for mediating agrin's ability to cluster AChR (Glass et al. 1996, Sanes & Lichtman 2001, Burden et al. 2003) and the coreceptor LRP4 (Kim et al. 2008, Zhang et al. 2008, Zong et al. 2012).", "cellular_location": "extracellular region, plasma membrane", "input_participant_list": [], "output_participant_list": [], "enzyme_list": [ "O15146-1" ], "evidence": [ { "id": "R-HSA-2467633", "database": "Reactome", "url": "https://www.reactome.org/PathwayBrowser/#R-HSA-2467633" } ] } ], "reaction_participants": [], "reaction_enzymes": [ { "uniprot_ac": "A0A0G2JW59", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A0G2JW59", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2JW59" } ] } ] }, { "uniprot_ac": "A0A0G2K6M9", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0G2K6M9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0G2K6M9" } ] } ] }, { "uniprot_ac": "A0A0R4J8U1", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A0R4J8U1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A0R4J8U1" } ] } ] }, { "uniprot_ac": "A0A8I5ZP97", "gene_name": "Dyrk1b", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I5ZP97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZP97" } ] } ] }, { "uniprot_ac": "A0A8I5ZVE3", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I5ZVE3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I5ZVE3" } ] } ] }, { "uniprot_ac": "A0A8I6A5T6", "gene_name": "Mst1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6A5T6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6A5T6" } ] } ] }, { "uniprot_ac": "A0A8I6AM23", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "A0A8I6AM23", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AM23" } ] } ] }, { "uniprot_ac": "A0A8I6AWX7", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "A0A8I6AWX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6AWX7" } ] } ] }, { "uniprot_ac": "A0A8I6GCV6", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "A0A8I6GCV6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/A0A8I6GCV6" } ] } ] }, { "uniprot_ac": "B1WC09", "gene_name": "Ddr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B1WC09", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B1WC09" } ] } ] }, { "uniprot_ac": "B2RYC7", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "B2RYC7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B2RYC7" } ] } ] }, { "uniprot_ac": "B5DFD6", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "B5DFD6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/B5DFD6" } ] } ] }, { "uniprot_ac": "D3ZBN3", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZBN3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZBN3" } ] } ] }, { "uniprot_ac": "D3ZCD0", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZCD0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZCD0" } ] } ] }, { "uniprot_ac": "D3ZD03", "gene_name": "Tyk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZD03", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZD03" } ] } ] }, { "uniprot_ac": "D3ZDH4", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZDH4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDH4" } ] } ] }, { "uniprot_ac": "D3ZDS3", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZDS3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZDS3" } ] } ] }, { "uniprot_ac": "D3ZJI4", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D3ZJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZJI4" } ] } ] }, { "uniprot_ac": "D3ZZK3", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "D3ZZK3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D3ZZK3" } ] } ] }, { "uniprot_ac": "D4A584", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A584", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A584" } ] } ] }, { "uniprot_ac": "D4A7W7", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4A7W7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4A7W7" } ] } ] }, { "uniprot_ac": "D4ADZ5", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "D4ADZ5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/D4ADZ5" } ] } ] }, { "uniprot_ac": "E1JHB7", "gene_name": "Pvr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E1JHB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E1JHB7" } ] } ] }, { "uniprot_ac": "E9PSY0", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "E9PSY0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PSY0" } ] } ] }, { "uniprot_ac": "E9PT20", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "E9PT20", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/E9PT20" } ] } ] }, { "uniprot_ac": "F1LM93", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LM93", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LM93" } ] } ] }, { "uniprot_ac": "F1LRZ0", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LRZ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LRZ0" } ] } ] }, { "uniprot_ac": "F1LSG7", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSG7" } ] } ] }, { "uniprot_ac": "F1LSN4", "gene_name": "Fgfr3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1LSN4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LSN4" } ] } ] }, { "uniprot_ac": "F1LVI0", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1LVI0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LVI0" } ] } ] }, { "uniprot_ac": "F1LYY7", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "F1LYY7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1LYY7" } ] } ] }, { "uniprot_ac": "F1M0N1", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "F1M0N1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1M0N1" } ] } ] }, { "uniprot_ac": "F1MAJ0", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "F1MAJ0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/F1MAJ0" } ] } ] }, { "uniprot_ac": "G3V6K6", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V6K6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V6K6" } ] } ] }, { "uniprot_ac": "G3V783", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "G3V783", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V783" } ] } ] }, { "uniprot_ac": "G3V9H8", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "G3V9H8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/G3V9H8" } ] } ] }, { "uniprot_ac": "M0R7E7", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "M0R7E7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0R7E7" } ] } ] }, { "uniprot_ac": "M0RDA4", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "M0RDA4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/M0RDA4" } ] } ] }, { "uniprot_ac": "O08680", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08680" } ] } ] }, { "uniprot_ac": "O08775", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O08775", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O08775" } ] } ] }, { "uniprot_ac": "O09110", "gene_name": "Map2k3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O09110", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09110" } ] } ] }, { "uniprot_ac": "O09127", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O09127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O09127" } ] } ] }, { "uniprot_ac": "O14733", "gene_name": "MAP2K7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O14733", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O14733" } ] } ] }, { "uniprot_ac": "O15146", "gene_name": "MUSK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "O15146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O15146" } ] } ] }, { "uniprot_ac": "O35346", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O35346", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35346" } ] } ] }, { "uniprot_ac": "O35491", "gene_name": "Clk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35491" } ] } ] }, { "uniprot_ac": "O35492", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35492", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35492" } ] } ] }, { "uniprot_ac": "O35493", "gene_name": "Clk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O35493", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O35493" } ] } ] }, { "uniprot_ac": "O43353", "gene_name": "RIPK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O43353", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43353" } ] } ] }, { "uniprot_ac": "O43781", "gene_name": "DYRK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O43781", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O43781" } ] } ] }, { "uniprot_ac": "O54804", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "O54804", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54804" } ] } ] }, { "uniprot_ac": "O54967", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O54967", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O54967" } ] } ] }, { "uniprot_ac": "O60674", "gene_name": "JAK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "O60674", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O60674" } ] } ] }, { "uniprot_ac": "O61444", "gene_name": "Mkk4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O61444", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O61444" } ] } ] }, { "uniprot_ac": "O62602", "gene_name": "lic", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "O62602", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O62602" } ] } ] }, { "uniprot_ac": "O70146", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "O70146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O70146" } ] } ] }, { "uniprot_ac": "O75716", "gene_name": "STK16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O75716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O75716" } ] } ] }, { "uniprot_ac": "O88697", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "O88697", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/O88697" } ] } ] }, { "uniprot_ac": "P00519", "gene_name": "ABL1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00519", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00519" } ] } ] }, { "uniprot_ac": "P00520", "gene_name": "Abl1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00520", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00520" } ] } ] }, { "uniprot_ac": "P00522", "gene_name": "Abl", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00522", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00522" } ] } ] }, { "uniprot_ac": "P00528", "gene_name": "Src64B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P00528", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00528" } ] } ] }, { "uniprot_ac": "P00533", "gene_name": "EGFR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P00533", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P00533" } ] } ] }, { "uniprot_ac": "P04412", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04412", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04412" } ] } ] }, { "uniprot_ac": "P04626", "gene_name": "ERBB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04626", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04626" } ] } ] }, { "uniprot_ac": "P04629", "gene_name": "NTRK1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P04629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P04629" } ] } ] }, { "uniprot_ac": "P05480", "gene_name": "Src", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P05480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05480" } ] } ] }, { "uniprot_ac": "P05532", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05532", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05532" } ] } ] }, { "uniprot_ac": "P05622", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P05622", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P05622" } ] } ] }, { "uniprot_ac": "P06213", "gene_name": "INSR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06213", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06213" } ] } ] }, { "uniprot_ac": "P06239", "gene_name": "LCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06239", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06239" } ] } ] }, { "uniprot_ac": "P06240", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06240" } ] } ] }, { "uniprot_ac": "P06241", "gene_name": "FYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P06241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06241" } ] } ] }, { "uniprot_ac": "P06494", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P06494", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06494" } ] } ] }, { "uniprot_ac": "P06784", "gene_name": "STE7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P06784", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P06784" } ] } ] }, { "uniprot_ac": "P07332", "gene_name": "FES", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07332" } ] } ] }, { "uniprot_ac": "P07333", "gene_name": "CSF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07333" } ] } ] }, { "uniprot_ac": "P07947", "gene_name": "YES1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07947", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07947" } ] } ] }, { "uniprot_ac": "P07948", "gene_name": "LYN", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P07948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07948" } ] } ] }, { "uniprot_ac": "P07949", "gene_name": "RET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P07949", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P07949" } ] } ] }, { "uniprot_ac": "P08018", "gene_name": "PBS2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P08018", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08018" } ] } ] }, { "uniprot_ac": "P08069", "gene_name": "IGF1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08069", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08069" } ] } ] }, { "uniprot_ac": "P08103", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08103", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08103" } ] } ] }, { "uniprot_ac": "P08581", "gene_name": "MET", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08581" } ] } ] }, { "uniprot_ac": "P08630", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08630", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08630" } ] } ] }, { "uniprot_ac": "P08631", "gene_name": "HCK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P08631", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08631" } ] } ] }, { "uniprot_ac": "P08922", "gene_name": "ROS1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08922", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08922" } ] } ] }, { "uniprot_ac": "P08923", "gene_name": "Ltk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P08923", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P08923" } ] } ] }, { "uniprot_ac": "P09208", "gene_name": "InR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09208" } ] } ] }, { "uniprot_ac": "P09215", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P09215", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09215" } ] } ] }, { "uniprot_ac": "P09581", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09581", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09581" } ] } ] }, { "uniprot_ac": "P09619", "gene_name": "PDGFRB", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09619", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09619" } ] } ] }, { "uniprot_ac": "P09759", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P09759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09759" } ] } ] }, { "uniprot_ac": "P09760", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09760" } ] } ] }, { "uniprot_ac": "P09769", "gene_name": "FGR", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P09769", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P09769" } ] } ] }, { "uniprot_ac": "P0C1S8", "gene_name": "WEE2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P0C1S8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P0C1S8" } ] } ] }, { "uniprot_ac": "P10721", "gene_name": "KIT", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P10721", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P10721" } ] } ] }, { "uniprot_ac": "P11362", "gene_name": "FGFR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P11362", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11362" } ] } ] }, { "uniprot_ac": "P11980", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P11980", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P11980" } ] } ] }, { "uniprot_ac": "P12931", "gene_name": "SRC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P12931", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P12931" } ] } ] }, { "uniprot_ac": "P13368", "gene_name": "sev", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P13368", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P13368" } ] } ] }, { "uniprot_ac": "P14234", "gene_name": "Fgr", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P14234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14234" } ] } ] }, { "uniprot_ac": "P14616", "gene_name": "INSRR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P14616", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14616" } ] } ] }, { "uniprot_ac": "P14618", "gene_name": "PKM", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14618" } ] } ] }, { "uniprot_ac": "P14680", "gene_name": "YAK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P14680" } ] } ] }, { "uniprot_ac": "P15127", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15127", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15127" } ] } ] }, { "uniprot_ac": "P15208", "gene_name": "Insr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15208", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15208" } ] } ] }, { "uniprot_ac": "P15209", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P15209", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P15209" } ] } ] }, { "uniprot_ac": "P16056", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16056", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16056" } ] } ] }, { "uniprot_ac": "P16092", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16092", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16092" } ] } ] }, { "uniprot_ac": "P16234", "gene_name": "PDGFRA", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P16234", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16234" } ] } ] }, { "uniprot_ac": "P16277", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16277", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16277" } ] } ] }, { "uniprot_ac": "P16591", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16591", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16591" } ] } ] }, { "uniprot_ac": "P16879", "gene_name": "Fes", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P16879", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P16879" } ] } ] }, { "uniprot_ac": "P17948", "gene_name": "FLT1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P17948", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P17948" } ] } ] }, { "uniprot_ac": "P18106", "gene_name": "FER", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18106", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18106" } ] } ] }, { "uniprot_ac": "P18160", "gene_name": "splA", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18160", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18160" } ] } ] }, { "uniprot_ac": "P18161", "gene_name": "splB", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P18161", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18161" } ] } ] }, { "uniprot_ac": "P18475", "gene_name": "tor", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P18475", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P18475" } ] } ] }, { "uniprot_ac": "P19525", "gene_name": "EIF2AK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P19525", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P19525" } ] } ] }, { "uniprot_ac": "P20786", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P20786", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P20786" } ] } ] }, { "uniprot_ac": "P21709", "gene_name": "EPHA1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21709", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21709" } ] } ] }, { "uniprot_ac": "P21802", "gene_name": "FGFR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21802" } ] } ] }, { "uniprot_ac": "P21803", "gene_name": "Fgfr2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21803", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21803" } ] } ] }, { "uniprot_ac": "P21860", "gene_name": "ERBB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P21860", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21860" } ] } ] }, { "uniprot_ac": "P21965", "gene_name": "MCK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P21965", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P21965" } ] } ] }, { "uniprot_ac": "P22216", "gene_name": "RAD53", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22216", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22216" } ] } ] }, { "uniprot_ac": "P22455", "gene_name": "FGFR4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22455", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22455" } ] } ] }, { "uniprot_ac": "P22518", "gene_name": "Clk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P22518", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22518" } ] } ] }, { "uniprot_ac": "P22607", "gene_name": "FGFR3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P22607", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P22607" } ] } ] }, { "uniprot_ac": "P23458", "gene_name": "JAK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P23458", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P23458" } ] } ] }, { "uniprot_ac": "P24062", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P24062", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24062" } ] } ] }, { "uniprot_ac": "P24604", "gene_name": "Tec", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P24604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P24604" } ] } ] }, { "uniprot_ac": "P25911", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P25911", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P25911" } ] } ] }, { "uniprot_ac": "P26618", "gene_name": "Pdgfra", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P26618", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P26618" } ] } ] }, { "uniprot_ac": "P28867", "gene_name": "Prkcd", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "P28867", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P28867" } ] } ] }, { "uniprot_ac": "P29317", "gene_name": "EPHA2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29317", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29317" } ] } ] }, { "uniprot_ac": "P29319", "gene_name": "Epha3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29319", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29319" } ] } ] }, { "uniprot_ac": "P29320", "gene_name": "EPHA3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29320", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29320" } ] } ] }, { "uniprot_ac": "P29321", "gene_name": "Epha8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29321", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29321" } ] } ] }, { "uniprot_ac": "P29322", "gene_name": "EPHA8", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29322", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29322" } ] } ] }, { "uniprot_ac": "P29323", "gene_name": "EPHB2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29323", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29323" } ] } ] }, { "uniprot_ac": "P29376", "gene_name": "LTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P29376", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29376" } ] } ] }, { "uniprot_ac": "P29597", "gene_name": "TYK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P29597", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P29597" } ] } ] }, { "uniprot_ac": "P30291", "gene_name": "WEE1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P30291", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30291" } ] } ] }, { "uniprot_ac": "P30530", "gene_name": "AXL", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P30530", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P30530" } ] } ] }, { "uniprot_ac": "P31938", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P31938", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P31938" } ] } ] }, { "uniprot_ac": "P32350", "gene_name": "KNS1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P32350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32350" } ] } ] }, { "uniprot_ac": "P32490", "gene_name": "MKK1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32490", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32490" } ] } ] }, { "uniprot_ac": "P32491", "gene_name": "MKK2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P32491", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32491" } ] } ] }, { "uniprot_ac": "P32577", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P32577", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P32577" } ] } ] }, { "uniprot_ac": "P33981", "gene_name": "TTK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P33981", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P33981" } ] } ] }, { "uniprot_ac": "P34152", "gene_name": "Ptk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P34152", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34152" } ] } ] }, { "uniprot_ac": "P34925", "gene_name": "RYK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P34925", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P34925" } ] } ] }, { "uniprot_ac": "P35546", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35546", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35546" } ] } ] }, { "uniprot_ac": "P35590", "gene_name": "TIE1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35590", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35590" } ] } ] }, { "uniprot_ac": "P35739", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35739", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35739" } ] } ] }, { "uniprot_ac": "P35761", "gene_name": "Ttk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P35761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35761" } ] } ] }, { "uniprot_ac": "P35790", "gene_name": "CHKA", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "P35790", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35790" } ] } ] }, { "uniprot_ac": "P35916", "gene_name": "FLT4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35916", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35916" } ] } ] }, { "uniprot_ac": "P35917", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35917", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35917" } ] } ] }, { "uniprot_ac": "P35918", "gene_name": "Kdr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35918", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35918" } ] } ] }, { "uniprot_ac": "P35968", "gene_name": "KDR", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35968", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35968" } ] } ] }, { "uniprot_ac": "P35969", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P35969", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35969" } ] } ] }, { "uniprot_ac": "P35991", "gene_name": "Btk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P35991", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P35991" } ] } ] }, { "uniprot_ac": "P36506", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36506", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36506" } ] } ] }, { "uniprot_ac": "P36507", "gene_name": "MAP2K2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P36507", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36507" } ] } ] }, { "uniprot_ac": "P36888", "gene_name": "FLT3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P36888", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P36888" } ] } ] }, { "uniprot_ac": "P39688", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P39688", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P39688" } ] } ] }, { "uniprot_ac": "P41240", "gene_name": "CSK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41240", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41240" } ] } ] }, { "uniprot_ac": "P41241", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41241", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41241" } ] } ] }, { "uniprot_ac": "P41242", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41242", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41242" } ] } ] }, { "uniprot_ac": "P41243", "gene_name": "Matk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P41243", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P41243" } ] } ] }, { "uniprot_ac": "P42679", "gene_name": "MATK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42679", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42679" } ] } ] }, { "uniprot_ac": "P42680", "gene_name": "TEC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42680" } ] } ] }, { "uniprot_ac": "P42681", "gene_name": "TXK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42681", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42681" } ] } ] }, { "uniprot_ac": "P42682", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42682", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42682" } ] } ] }, { "uniprot_ac": "P42684", "gene_name": "ABL2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42684", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42684" } ] } ] }, { "uniprot_ac": "P42685", "gene_name": "FRK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P42685", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P42685" } ] } ] }, { "uniprot_ac": "P43403", "gene_name": "ZAP70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43403", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43403" } ] } ] }, { "uniprot_ac": "P43404", "gene_name": "Zap70", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43404", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43404" } ] } ] }, { "uniprot_ac": "P43405", "gene_name": "SYK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P43405", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P43405" } ] } ] }, { "uniprot_ac": "P45985", "gene_name": "MAP2K4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P45985", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P45985" } ] } ] }, { "uniprot_ac": "P46734", "gene_name": "MAP2K3", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P46734", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P46734" } ] } ] }, { "uniprot_ac": "P47809", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P47809", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47809" } ] } ] }, { "uniprot_ac": "P47810", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P47810", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P47810" } ] } ] }, { "uniprot_ac": "P48025", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P48025", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P48025" } ] } ] }, { "uniprot_ac": "P49657", "gene_name": "mnb", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49657", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49657" } ] } ] }, { "uniprot_ac": "P49759", "gene_name": "CLK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49759" } ] } ] }, { "uniprot_ac": "P49760", "gene_name": "CLK2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49760" } ] } ] }, { "uniprot_ac": "P49761", "gene_name": "CLK3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49761" } ] } ] }, { "uniprot_ac": "P49762", "gene_name": "Doa", "activity": [ { "ec_number": "2.7.11.-", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P49762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P49762" } ] } ] }, { "uniprot_ac": "P50545", "gene_name": "Hck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P50545", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P50545" } ] } ] }, { "uniprot_ac": "P51451", "gene_name": "BLK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51451" } ] } ] }, { "uniprot_ac": "P51813", "gene_name": "BMX", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P51813", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P51813" } ] } ] }, { "uniprot_ac": "P52332", "gene_name": "Jak1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52332", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52332" } ] } ] }, { "uniprot_ac": "P52333", "gene_name": "JAK3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P52333", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52333" } ] } ] }, { "uniprot_ac": "P52480", "gene_name": "Pkm", "activity": [ { "ec_number": "2.7.1.40", "activity": "CTP + pyruvate = CDP + H(+) + phosphoenolpyruvate.", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.1.40", "activity": "", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52480", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52480" } ] } ] }, { "uniprot_ac": "P52564", "gene_name": "MAP2K6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P52564", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P52564" } ] } ] }, { "uniprot_ac": "P53767", "gene_name": "Flt1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P53767", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P53767" } ] } ] }, { "uniprot_ac": "P54199", "gene_name": "MPS1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P54199", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54199" } ] } ] }, { "uniprot_ac": "P54350", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P54350", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54350" } ] } ] }, { "uniprot_ac": "P54753", "gene_name": "EPHB3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54753", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54753" } ] } ] }, { "uniprot_ac": "P54754", "gene_name": "Ephb3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54754", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54754" } ] } ] }, { "uniprot_ac": "P54756", "gene_name": "EPHA5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54756", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54756" } ] } ] }, { "uniprot_ac": "P54757", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54757", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54757" } ] } ] }, { "uniprot_ac": "P54758", "gene_name": "Epha6", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54758", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54758" } ] } ] }, { "uniprot_ac": "P54759", "gene_name": "Epha7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54759", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54759" } ] } ] }, { "uniprot_ac": "P54760", "gene_name": "EPHB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54760" } ] } ] }, { "uniprot_ac": "P54761", "gene_name": "Ephb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54761", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54761" } ] } ] }, { "uniprot_ac": "P54762", "gene_name": "EPHB1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54762", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54762" } ] } ] }, { "uniprot_ac": "P54763", "gene_name": "Ephb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54763" } ] } ] }, { "uniprot_ac": "P54764", "gene_name": "EPHA4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P54764", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P54764" } ] } ] }, { "uniprot_ac": "P55144", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55144", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55144" } ] } ] }, { "uniprot_ac": "P55146", "gene_name": "Tyro3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P55146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P55146" } ] } ] }, { "uniprot_ac": "P57097", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P57097", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57097" } ] } ] }, { "uniprot_ac": "P57760", "gene_name": "Stk16", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P57760", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P57760" } ] } ] }, { "uniprot_ac": "P58801", "gene_name": "Ripk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "P58801", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P58801" } ] } ] }, { "uniprot_ac": "P70236", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "P70236", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70236" } ] } ] }, { "uniprot_ac": "P70424", "gene_name": "Erbb2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P70424", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70424" } ] } ] }, { "uniprot_ac": "P70451", "gene_name": "Fer", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70451", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70451" } ] } ] }, { "uniprot_ac": "P70600", "gene_name": "Ptk2b", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P70600", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P70600" } ] } ] }, { "uniprot_ac": "P83102", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "P83102", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P83102" } ] } ] }, { "uniprot_ac": "P97504", "gene_name": "Bmx", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "P97504", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97504" } ] } ] }, { "uniprot_ac": "P97523", "gene_name": "Met", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97523", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97523" } ] } ] }, { "uniprot_ac": "P97793", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "P97793", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/P97793" } ] } ] }, { "uniprot_ac": "Q00342", "gene_name": "Flt3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00342", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00342" } ] } ] }, { "uniprot_ac": "Q00495", "gene_name": "Csf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00495", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00495" } ] } ] }, { "uniprot_ac": "Q00993", "gene_name": "Axl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q00993", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q00993" } ] } ] }, { "uniprot_ac": "Q01134", "gene_name": "Chka", "activity": [ { "ec_number": "2.7.1.82", "activity": "ATP + ethanolamine = ADP + H(+) + phosphoethanolamine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.82", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "ATP + choline = ADP + H(+) + phosphocholine.", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] }, { "ec_number": "2.7.1.32", "activity": "", "evidence": [ { "id": "Q01134", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01134" } ] } ] }, { "uniprot_ac": "Q01279", "gene_name": "Egfr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01279", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01279" } ] } ] }, { "uniprot_ac": "Q01621", "gene_name": "Lck", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q01621", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01621" } ] } ] }, { "uniprot_ac": "Q01887", "gene_name": "Ryk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01887", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01887" } ] } ] }, { "uniprot_ac": "Q01974", "gene_name": "ROR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q01974", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01974" } ] } ] }, { "uniprot_ac": "Q01986", "gene_name": "Map2k1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q01986", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q01986" } ] } ] }, { "uniprot_ac": "Q02750", "gene_name": "MAP2K1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q02750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02750" } ] } ] }, { "uniprot_ac": "Q02763", "gene_name": "TEK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02763", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02763" } ] } ] }, { "uniprot_ac": "Q02858", "gene_name": "Tek", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q02858", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q02858" } ] } ] }, { "uniprot_ac": "Q03137", "gene_name": "Epha4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03137", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03137" } ] } ] }, { "uniprot_ac": "Q03142", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03142", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03142" } ] } ] }, { "uniprot_ac": "Q03145", "gene_name": "Epha2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03145" } ] } ] }, { "uniprot_ac": "Q03146", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03146", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03146" } ] } ] }, { "uniprot_ac": "Q03351", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q03351", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03351" } ] } ] }, { "uniprot_ac": "Q03526", "gene_name": "Itk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q03526", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03526" } ] } ] }, { "uniprot_ac": "Q03963", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q03963", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q03963" } ] } ] }, { "uniprot_ac": "Q04589", "gene_name": "Fgfr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04589", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04589" } ] } ] }, { "uniprot_ac": "Q04736", "gene_name": "Yes1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q04736", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04736" } ] } ] }, { "uniprot_ac": "Q04912", "gene_name": "MST1R", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q04912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q04912" } ] } ] }, { "uniprot_ac": "Q05030", "gene_name": "Pdgfrb", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q05030", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05030" } ] } ] }, { "uniprot_ac": "Q05397", "gene_name": "PTK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q05397", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05397" } ] } ] }, { "uniprot_ac": "Q05655", "gene_name": "PRKCD", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] }, { "ec_number": "2.7.11.13", "activity": "", "evidence": [ { "id": "Q05655", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q05655" } ] } ] }, { "uniprot_ac": "Q06187", "gene_name": "BTK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q06187", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06187" } ] } ] }, { "uniprot_ac": "Q06418", "gene_name": "TYRO3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06418", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06418" } ] } ] }, { "uniprot_ac": "Q06806", "gene_name": "Tie1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q06806", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q06806" } ] } ] }, { "uniprot_ac": "Q07014", "gene_name": "Lyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07014", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07014" } ] } ] }, { "uniprot_ac": "Q07407", "gene_name": "htl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q07407", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07407" } ] } ] }, { "uniprot_ac": "Q07912", "gene_name": "TNK2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q07912", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q07912" } ] } ] }, { "uniprot_ac": "Q08345", "gene_name": "DDR1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q08345", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08345" } ] } ] }, { "uniprot_ac": "Q08881", "gene_name": "ITK", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q08881", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q08881" } ] } ] }, { "uniprot_ac": "Q09147", "gene_name": "btl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q09147", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q09147" } ] } ] }, { "uniprot_ac": "Q12866", "gene_name": "MERTK", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q12866", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q12866" } ] } ] }, { "uniprot_ac": "Q13163", "gene_name": "MAP2K5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q13163", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13163" } ] } ] }, { "uniprot_ac": "Q13470", "gene_name": "TNK1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13470" } ] } ] }, { "uniprot_ac": "Q13627", "gene_name": "DYRK1A", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q13627", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13627" } ] } ] }, { "uniprot_ac": "Q13882", "gene_name": "PTK6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q13882", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q13882" } ] } ] }, { "uniprot_ac": "Q14289", "gene_name": "PTK2B", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q14289", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14289" } ] } ] }, { "uniprot_ac": "Q14680", "gene_name": "MELK", "activity": [ { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] }, { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q14680", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q14680" } ] } ] }, { "uniprot_ac": "Q15303", "gene_name": "ERBB4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15303", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15303" } ] } ] }, { "uniprot_ac": "Q15375", "gene_name": "EPHA7", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q15375", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15375" } ] } ] }, { "uniprot_ac": "Q15569", "gene_name": "TESK1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q15569", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q15569" } ] } ] }, { "uniprot_ac": "Q16288", "gene_name": "NTRK3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16288", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16288" } ] } ] }, { "uniprot_ac": "Q16620", "gene_name": "NTRK2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16620", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16620" } ] } ] }, { "uniprot_ac": "Q16832", "gene_name": "DDR2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q16832", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q16832" } ] } ] }, { "uniprot_ac": "Q23977", "gene_name": "hep", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q23977", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q23977" } ] } ] }, { "uniprot_ac": "Q24145", "gene_name": "Shark", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24145", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24145" } ] } ] }, { "uniprot_ac": "Q24324", "gene_name": "Dsor1", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q24324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24324" } ] } ] }, { "uniprot_ac": "Q24488", "gene_name": "Ror", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q24488", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24488" } ] } ] }, { "uniprot_ac": "Q24592", "gene_name": "hop", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q24592", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q24592" } ] } ] }, { "uniprot_ac": "Q27324", "gene_name": "drl", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q27324", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q27324" } ] } ] }, { "uniprot_ac": "Q3UFB7", "gene_name": "Ntrk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q3UFB7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q3UFB7" } ] } ] }, { "uniprot_ac": "Q498D6", "gene_name": "Fgfr4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q498D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q498D6" } ] } ] }, { "uniprot_ac": "Q4JIM5", "gene_name": "Abl2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4JIM5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4JIM5" } ] } ] }, { "uniprot_ac": "Q4KM97", "gene_name": "Blk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q4KM97", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KM97" } ] } ] }, { "uniprot_ac": "Q4KSH6", "gene_name": "Map2k4", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH6" } ] } ] }, { "uniprot_ac": "Q4KSH7", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q4KSH7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4KSH7" } ] } ] }, { "uniprot_ac": "Q4V8A3", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q4V8A3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q4V8A3" } ] } ] }, { "uniprot_ac": "Q501W1", "gene_name": "Txk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q501W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q501W1" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q501W1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q501W1" } ] } ] }, { "uniprot_ac": "Q504Y2", "gene_name": "PKDCC", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q504Y2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q504Y2" } ] } ] }, { "uniprot_ac": "Q54BC9", "gene_name": "dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54BC9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54BC9" } ] } ] }, { "uniprot_ac": "Q54G28", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54G28", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54G28" } ] } ] }, { "uniprot_ac": "Q54I36", "gene_name": "pyk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54I36", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54I36" } ] } ] }, { "uniprot_ac": "Q54N73", "gene_name": "7tmk1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q54N73", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54N73" } ] } ] }, { "uniprot_ac": "Q54QV3", "gene_name": "yakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q54QV3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54QV3" } ] } ] }, { "uniprot_ac": "Q54R58", "gene_name": "", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q54R58", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q54R58" } ] } ] }, { "uniprot_ac": "Q552C6", "gene_name": "zak2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q552C6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q552C6" } ] } ] }, { "uniprot_ac": "Q55CL6", "gene_name": "mekA", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q55CL6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q55CL6" } ] } ] }, { "uniprot_ac": "Q5FVG7", "gene_name": "Srms", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5FVG7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5FVG7" } ] } ] }, { "uniprot_ac": "Q5JZY3", "gene_name": "EPHA10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q5JZY3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5JZY3" } ] } ] }, { "uniprot_ac": "Q5RJI4", "gene_name": "Pkdcc", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5RJI4", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5RJI4" } ] } ] }, { "uniprot_ac": "Q5U2X5", "gene_name": "Tnk2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q5U2X5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U2X5" } ] } ] }, { "uniprot_ac": "Q5U4C9", "gene_name": "Dyrk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q5U4C9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q5U4C9" } ] } ] }, { "uniprot_ac": "Q60629", "gene_name": "Epha5", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60629" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60629", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60629" } ] } ] }, { "uniprot_ac": "Q60750", "gene_name": "Epha1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60750", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60750" } ] } ] }, { "uniprot_ac": "Q60751", "gene_name": "Igf1r", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60751", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60751" } ] } ] }, { "uniprot_ac": "Q60805", "gene_name": "Mertk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q60805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60805" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q60805", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q60805" } ] } ] }, { "uniprot_ac": "Q61006", "gene_name": "Musk", 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"database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62838", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62838" } ] } ] }, { "uniprot_ac": "Q62844", "gene_name": "Fyn", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q62844", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62844" } ] } ] }, { "uniprot_ac": "Q62862", "gene_name": "Map2k5", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q62862", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62862" } ] } ] }, { "uniprot_ac": "Q62956", "gene_name": "Erbb4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q62956", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q62956" } ] } ] }, { "uniprot_ac": "Q63116", "gene_name": "Kit", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63116", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63116" } ] } ] }, { "uniprot_ac": "Q63117", "gene_name": "Clk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63117", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63117" } ] } ] }, { "uniprot_ac": "Q63132", "gene_name": "Ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63132", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63132" } ] } ] }, { "uniprot_ac": "Q63184", "gene_name": "Eif2ak2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] }, { "ec_number": "2.7.11.1", "activity": "", "evidence": [ { "id": "Q63184", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63184" } ] } ] }, { "uniprot_ac": "Q63272", "gene_name": "Jak3", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63272", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63272" } ] } ] }, { "uniprot_ac": "Q63470", "gene_name": "Dyrk1a", "activity": [ { "ec_number": "2.7.11.23", "activity": "[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.11.23", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63470", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63470" } ] } ] }, { "uniprot_ac": "Q63474", "gene_name": "Ddr1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63474", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63474" } ] } ] }, { "uniprot_ac": "Q63572", "gene_name": "Tesk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q63572", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63572" } ] } ] }, { "uniprot_ac": "Q63604", "gene_name": "Ntrk2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q63604", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63604" } ] } ] }, { "uniprot_ac": "Q63802", "gene_name": "Wee1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q63802", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63802" } ] } ] }, { "uniprot_ac": "Q63932", "gene_name": "Map2k2", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q63932", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q63932" } ] } ] }, { "uniprot_ac": "Q64434", "gene_name": "Ptk6", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64434" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q64434", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64434" } ] } ] }, { "uniprot_ac": "Q64716", "gene_name": "Insrr", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q64716", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64716" } ] } ] }, { "uniprot_ac": "Q64725", "gene_name": "Syk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q64725", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q64725" } ] } ] }, { "uniprot_ac": "Q66JT0", "gene_name": "Wee2", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q66JT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q66JT0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q66JT0" } ] } ] }, { "uniprot_ac": "Q6J9G0", "gene_name": "STYK1", 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O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q6P6U0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6P6U0" } ] } ] }, { "uniprot_ac": "Q6VNS1", "gene_name": "Ntrk3", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VNS1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q6VNS1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6VNS1" } ] } ] }, { "uniprot_ac": "Q6XUX1", "gene_name": "Dstyk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX1" } ] } ] }, { "uniprot_ac": "Q6XUX2", "gene_name": "Dstyk", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX2" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX2" } ] } ] }, { "uniprot_ac": "Q6XUX3", "gene_name": "DSTYK", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q6XUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX3" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q6XUX3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q6XUX3" } ] } ] }, { "uniprot_ac": "Q75JK0", "gene_name": "zakA", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q75JK0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q75JK0" } ] } ] }, { "uniprot_ac": "Q76NV1", "gene_name": "dyrk1", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q76NV1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q76NV1" } ] } ] }, { "uniprot_ac": "Q78DX7", "gene_name": "Ros1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q78DX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78DX7" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q78DX7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q78DX7" } ] } ] }, { "uniprot_ac": "Q7KJ08", "gene_name": "Alk", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q7KJ08", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KJ08" } ] } ] }, { "uniprot_ac": "Q7KT06", "gene_name": "Ret", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q7KT06", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q7KT06" } ] } ] }, { "uniprot_ac": "Q8BI55", "gene_name": "Dyrk4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8BI55", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BI55" } ] } ] }, { "uniprot_ac": "Q8BYG9", "gene_name": "Epha10", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8BYG9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8BYG9" } ] } ] }, { "uniprot_ac": "Q8CBF3", "gene_name": "Ephb1", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q8CBF3", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CBF3" } ] } ] }, { "uniprot_ac": "Q8CE90", "gene_name": "Map2k7", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q8CE90", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8CE90" } ] } ] }, { "uniprot_ac": "Q8INJ8", "gene_name": "Csk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q8INJ8", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8INJ8" } ] } ] }, { "uniprot_ac": "Q8VCT9", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q8VCT9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q8VCT9" } ] } ] }, { "uniprot_ac": "Q91ZT1", "gene_name": "Flt4", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q91ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZT1" } ] }, { "ec_number": "2.7.10.1", "activity": "", "evidence": [ { "id": "Q91ZT1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q91ZT1" } ] } ] }, { "uniprot_ac": "Q922K9", "gene_name": "Frk", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q922K9", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922K9" } ] } ] }, { "uniprot_ac": "Q922Y0", "gene_name": "Dyrk3", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q922Y0", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q922Y0" } ] } ] }, { "uniprot_ac": "Q924U5", "gene_name": "Tesk2", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q924U5", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q924U5" } ] } ] }, { "uniprot_ac": "Q925D6", "gene_name": "Map2k6", "activity": [ { "ec_number": "2.7.12.2", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q925D6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q925D6" } ] } ] }, { "uniprot_ac": "Q92630", "gene_name": "DYRK2", "activity": [ 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"evidence": [ { "id": "Q96S53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96S53" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q96S53", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q96S53" } ] } ] }, { "uniprot_ac": "Q99ML2", "gene_name": "Tnk1", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q99ML2", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q99ML2" } ] } ] }, { "uniprot_ac": "Q9H3Y6", "gene_name": "SRMS", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9H3Y6", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9H3Y6" } ] } ] }, { "uniprot_ac": "Q9HAZ1", "gene_name": "CLK4", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9HAZ1", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9HAZ1" } ] } ] }, { "uniprot_ac": "Q9I7F7", "gene_name": "Ack-like", "activity": [ { "ec_number": "2.7.10.2", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9I7F7" } ] }, { "ec_number": "2.7.10.2", "activity": "", "evidence": [ { "id": "Q9I7F7", "database": "UniProtKB", 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"Q9WVS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS7" } ] }, { "ec_number": "2.7.12.2", "activity": "", "evidence": [ { "id": "Q9WVS7", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9WVS7" } ] } ] }, { "uniprot_ac": "Q9Y463", "gene_name": "DYRK1B", "activity": [ { "ec_number": "2.7.12.1", "activity": "ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein].", "evidence": [ { "id": "Q9Y463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y463" } ] }, { "ec_number": "2.7.12.1", "activity": "", "evidence": [ { "id": "Q9Y463", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Y463" } ] } ] }, { "uniprot_ac": "Q9Z138", "gene_name": "Ror2", "activity": [ { "ec_number": "2.7.10.1", "activity": "ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein].", "evidence": [ { "id": "Q9Z138", "database": "UniProtKB", "url": "https://www.uniprot.org/uniprot/Q9Z138" } ] }, { "ec_number": 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"https://www.uniprot.org/uniprot/Q9Z277" } ] } ] } ], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "sequence_features": { "n_linked_sites": [ 222, 338 ], "o_linked_sites": [], "snv_sites": [ 104, 193, 222, 242, 300, 338, 413, 479, 500, 528, 575, 669, 750, 763, 848, 854 ], "glycation_sites": [], "phosphorylation_sites": [ 554, 681, 698, 755 ], "sequon_annotation_sites": [ { "start_pos": 222, "end_pos": 224 }, { "start_pos": 338, "end_pos": 340 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 3 }, { "field": "total_sites", "count": 3 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 2 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment", "start_pos", "start_aa", "end_pos", "end_aa", "residue", "site_lbl" ] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 4 }, { "field": "total_sites", "count": 4 } ], "sort_fields": [ "start_pos", "end_pos", "kinase_uniprot_canonical_ac", "kinase_gene_name", "residue", "comment", "site_lbl" ] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 18 }, { "field": "total_sites", "count": 16 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 12 }, { "field": "total_sites", "count": 11 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 6 }, { "field": "total_sites", "count": 6 } ], "sort_fields": [ "start_pos", "end_pos", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl", "subjects_tested", "subjects_positive", "frequency" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 61 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }