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Review article", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" }, { "database": "PubMed", "id": "34014031", "url": "https://glygen.org/publication/PubMed/34014031" } ] }, { "annotation": "Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" }, { "database": "PubMed", "id": "32791513", "url": "https://glygen.org/publication/PubMed/32791513" } ] }, { "annotation": "Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" }, { "database": "PubMed", "id": "33737391", "url": "https://glygen.org/publication/PubMed/33737391" } ] }, { "annotation": "New Evidence of Gut Microbiota Involvement in the Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint Clinical and Animal Data. Publication Status: Online-Only", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" }, { "database": "PubMed", "id": "34992606", "url": "https://glygen.org/publication/PubMed/34992606" } ] }, { "annotation": "The results of this study suggested that significant novel association signals near the genes TRANK1 and provide supportive evidence for the previously reported association signals near ANK3 and within the 3p21.1 locus. Erratum:[Mol Psychiatry. 2013 Feb;18(2):264-6. Farmer, A [added]; McGuffin, P [added]; Craig, I [added]; Lewis, C [added]; Hosang, G [added]; Cohen-Woods, S [added]; Vincent, J B [added]; Kennedy, J L [added]; Strauss, J [added]]", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" }, { "database": "PubMed", "id": "22182935", "url": "https://glygen.org/publication/PubMed/22182935" } ] } ], "disease": [], "snv": [ { "evidence": [ { "id": "O15050", "database": "BioMuta", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15050" } ], "glycoeffect": [], "start_pos": 2617, "end_pos": 2617, "subjects_tested": "92", "subjects_positive": "1", "frequency": "1.1", "sequence_org": "R", "sequence_mut": "H", "comment": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.1%). 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"MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of the urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor of urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumor, urinary bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of bladder", "description": "" }, { "id": "MONDO:0001187", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0001187", "name": "malignant tumour of the 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"https://monarchinitiative.org/disease/MONDO:0005575", "name": "colon cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer with chromosomal instability, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, autosomal dominant, somatic mutation", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, somatic", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "colorectal cancer, susceptibility to, autosomal dominant, 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large bowel neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large bowel tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine neoplasm", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumor", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": "https://monarchinitiative.org/disease/MONDO:0005575", "name": "malignant large intestine tumour", "description": "" }, { "id": "MONDO:0005575", "resource": "MONDO", "url": 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"name": "Colorectal cancer", "description": "Colorectal cancer" } ] } ] } ], "species": [ { "name": "Homo sapiens", "taxid": 9606, "evidence": [ { "database": "UniProtKB", "id": "O15050", "url": "https://www.uniprot.org/uniprot/O15050" } ], "common_name": "Human" } ], "gene": [ { "name": "TRANK1", "url": "https://www.uniprot.org/uniprot/O15050", "locus": { "chromosome": "3", "start_pos": 36826819, "end_pos": 36945057, "strand": "+", "evidence": [ { "database": "Ensembl Gene", "id": "ENSG00000168016", "url": "https://www.ensembl.org/id/ENSG00000168016" } ] } } ], "crossref": [ { "id": "ENSG00000168016", "url": "https://bgee.org/?page=gene&gene_id=ENSG00000168016", "database": "Bgee", "categories": [ "Gene Expression" ] }, { "id": "O15050", "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/O15050", "database": "BioMuta", "categories": [ "Variation" ] }, { "id": "TRANK1", "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRANK1", "database": "GeneCards", "categories": [ "Gene Annotation", "Organism-specific" ] }, { "id": "9881", "url": "https://www.ncbi.nlm.nih.gov/gene/9881", "database": "GeneID", "categories": [ "Genome Annotation" ] }, { "id": "29011", "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=29011", "database": "HGNC", "categories": [ "Organism-specific" ] }, { "id": "O15050", "url": "https://www.ebi.ac.uk/intact/interactors/id:O15050*", "database": "IntAct", "categories": [ "Other" ] }, { "id": "IPR002110", "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR011990", "url": "https://www.ebi.ac.uk/interpro/entry/IPR011990", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR019734", "url": "https://www.ebi.ac.uk/interpro/entry/IPR019734", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR027417", "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR036770", "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "IPR039904", "url": "https://www.ebi.ac.uk/interpro/entry/IPR039904", "database": "InterPro", "categories": [ "Protein Classification" ] }, { "id": "hsa:9881", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9881", "database": "KEGG Pathway", "categories": [ "Enzyme and Pathway" ] }, { "id": "619316", "url": "http://www.omim.org/entry/619316", "database": "MIM", "categories": [ "Other" ] }, { "id": "NX_O15050", "url": "https://www.nextprot.org/entry/NX_O15050", "database": "neXtProt", "categories": [ "Protein", "Organism-specific" ] }, { "id": "O15050", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15050", "database": "O-GlcNAc Database", "categories": [ "Glycoproteomics" ] }, { "id": "DCCWRWD", "url": 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"https://pharos.nih.gov/targets/O15050", "database": "PHAROS", "categories": [ "Organism-specific" ] }, { "id": "PR_O15050", "url": "http://purl.obolibrary.org/obo/PR_O15050", "database": "PRO", "categories": [ "Protein" ] }, { "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646", "database": "RefSeq", "categories": [ "Protein" ] }, { "id": "A0A096LPF5", "url": "https://www.uniprot.org/uniprot/A0A096LPF5", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A096LPF5-1", "url": "https://www.uniprot.org/uniprot/A0A096LPF5-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y7N6", "url": "https://www.uniprot.org/uniprot/A0A2R8Y7N6", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y7N6-1", "url": "https://www.uniprot.org/uniprot/A0A2R8Y7N6-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y890", "url": "https://www.uniprot.org/uniprot/A0A2R8Y890", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y890-1", "url": "https://www.uniprot.org/uniprot/A0A2R8Y890-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y8A3", "url": "https://www.uniprot.org/uniprot/A0A2R8Y8A3", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8Y8A3-1", "url": "https://www.uniprot.org/uniprot/A0A2R8Y8A3-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YEM9", "url": "https://www.uniprot.org/uniprot/A0A2R8YEM9", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "A0A2R8YEM9-1", "url": "https://www.uniprot.org/uniprot/A0A2R8YEM9-1", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15050", "url": "https://www.uniprot.org/uniprot/O15050", "database": "UniProtKB", "categories": [ "Protein" ] }, { "id": "O15050-1", "url": "https://www.uniprot.org/uniprot/O15050-1", "database": "UniProtKB", "categories": [ "Protein" ] } ], "sequence": { "sequence": 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"length": 2925, "header": "sp|O15050-1|TRNK1_HUMAN Isoform 1 of TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=4 CANONICAL=O15050-1" }, "isoforms": [ { "isoform_ac": "A0A096LPF5-1", "url": "", "sequence": { "sequence": "MDLTAYAELLKESGNQVLKNGNFSLAIRKYDEAIQILLQLYQWGVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSS", "length": 137, "header": "tr|A0A096LPF5-1|TRNK1_HUMAN Computationally mapped isoform of TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=1 CANONICAL=O15050-1" }, "locus": { "chromosome": "3", "start_pos": 36908453, "end_pos": 36899107, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000463764.2", "url": "https://www.ensembl.org/id/ENST00000463764.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000485569.1", "url": "https://www.ensembl.org/id/ENSP00000485569.1" } ] } }, { "isoform_ac": "A0A2R8Y7N6-1", "url": "", "sequence": { "sequence": "XPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEGCPSWSKL", "length": 941, "header": "tr|A0A2R8Y7N6-1|TRNK1_HUMAN Computationally mapped isoform of TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=1 CANONICAL=O15050-1" }, "locus": { "chromosome": "3", "start_pos": 36857632, "end_pos": 36851393, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000643881.1", "url": "https://www.ensembl.org/id/ENST00000643881.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496256.1", "url": "https://www.ensembl.org/id/ENSP00000496256.1" } ] } }, { "isoform_ac": "A0A2R8Y890-1", "url": "", "sequence": { "sequence": "XMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEGCPSWSKL", "length": 612, "header": "tr|A0A2R8Y890-1|TRNK1_HUMAN Computationally mapped isoform of TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=1 CANONICAL=O15050-1" }, "locus": { "chromosome": "3", "start_pos": 36856645, "end_pos": 36851393, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646436.1", "url": "https://www.ensembl.org/id/ENST00000646436.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496740.1", "url": "https://www.ensembl.org/id/ENSP00000496740.1" } ] } }, { "isoform_ac": "A0A2R8Y8A3-1", "url": "", "sequence": { "sequence": "MDLTAYAELLKESGNQVLKNGNFSLAIRKYDEAIQILLQLYQWGVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEVLLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEGCPSWSKL", "length": 1629, "header": "tr|A0A2R8Y8A3-1|TRNK1_HUMAN Computationally mapped isoform of TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=1 CANONICAL=O15050-1" }, "locus": { "chromosome": "3", "start_pos": 36908453, "end_pos": 36851394, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000646897.1", "url": "https://www.ensembl.org/id/ENST00000646897.1" }, { "database": "Ensembl Peptide", "id": "ENSP00000496771.1", "url": "https://www.ensembl.org/id/ENSP00000496771.1" } ] } }, { "isoform_ac": "A0A2R8YEM9-1", "url": "", "sequence": { "sequence": "MWDPRAARMDLTAYAELLKESGNQVLKNGNFSLAIRKYDEAIQILLQLYQWGVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEVLLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTSTDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPAEWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSPKEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLKTKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLKSRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLGAARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQKLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSLVRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDLDLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMRFIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPKILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILKPNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYPEEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNRDDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEPLIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFSKKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVLLDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIESRLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLMDCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEMDELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQMERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAASEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEKVDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVEDLYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDYENEVEDFGELRPRRRSRKCGKQRKY", "length": 2969, "header": "tr|A0A2R8YEM9-1|TRNK1_HUMAN Computationally mapped isoform of TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=1 CANONICAL=O15050-1" }, "locus": { "chromosome": "3", "start_pos": 36944809, "end_pos": 36828278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000645898.2", "url": "https://www.ensembl.org/id/ENST00000645898.2" }, { "database": "Ensembl Peptide", "id": "ENSP00000494480.1", "url": "https://www.ensembl.org/id/ENSP00000494480.1" } ] } }, { "isoform_ac": "O15050-1", "url": "", "sequence": { "sequence": "MWDPRAARVPPRDLAVLLCNKSNAFFSLGKWNEAFVAAKECLQWDPTYVKGYYRAGYSLLRLHQPYEAARMFFEGLRLVQRSQDQAPVADFLVGVFTTMSSDSIVLQSFLPCFDHIFTTGFPTEVWQSVIEKLAKKGLWHSFLLLSAKKDRLPRNIHVPELSLKSLFEKYVFIGLYEKMEQVPKLVQWLISIGASVETIGPYPLHALMRLCIQARENHLFRWLMDHKPEWKGRINQKDGDGCTVLHVVAAHSPGYLVKRQTEDVQMLLRFGADPTLLDRQSRSVVDVLKRNKNFKAIEKINSHLEKLATCSKDLSGFSNGDGPTSENDIFRKVLEQLVKYMNSGNRLLHKNFLKQEVVQRFLRLLSTLQEIPPDLVCDINQDCATTVFKFLLEKQRWPEVLLLLTRKVSGEPPLGDCLIKDCNFSDLDICTIIPHLSTWDQRKKQLLGCLIDSGALPDGLQESQERPVVTCLKHEDFELAFLLLTKGADPRAISLTEGDTPLHAALHIFLEIKADIGFSFLSHLLDLFWSNPTEFDYLNPNVQDSNGNTLMHILFQKGMLKRVKKLLDLLVKFDINFNLKNKEGKDARHRIKKNDSLLLAWNKALMENRRRSRQDSAAHLGKLSKSTAPGHTSQLKSQGSFKSVPCGATARTLPEGSAVPDSWETLPGTQVTRKEPGALRPCSLRDCLMQDITVLIQQVEVDPSFPEDCLQSSEPLEAGAGKEGKKDDKPTLGAGAPDCSEVGEGHAQVGLGALQLVPDDNRGKEGNDDQDDWSTQEIEACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHLKGSIQLFEAKLDKGARMLWELAIDFSPRCSENPEKIIATEQNTCAMEKSGRIYTEIIRIWDIVLDHCKLADSIKAICNAYNRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKGREHVNPEYFPPASAVETEYNIMKFHSFSTNMAFNILNDTTATVEYPFRVGELEYAVIDLNPRPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLAKQVWLKRRLEVEPGKESPGGEEEEEEEDEEEEDSIEVETVESIDEQEYEACAGGAGVEPAGDGQAAEVCAPEHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNIHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIIGWSAQEESTIPSWQEDEEEAEVDGDYSEEDKAVEMRTGDSDPRVYVTFEVFKNEIWPKMTKGRTAYNPALIWKEIKSFLKGSFEALSCPHGRLTEEVYKKLGRKRCPNFKEDRSEIYSLFSLYQQIRSQKGYFDEEDVLYNISRRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNSMFLTGDTAQSIMKGVAFRFSDLRSLFHYASRNTIDKQCAVRKPKKIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTVLESCSVSDLAILLRGNKRKTQPIEFGAHQVILVANETAKEKIPEELGLALVLTIYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPTSTDSREENRPLVEVPLDKPGSSQGRSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENREKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPAEWIAQGDYYAKHQCWKVAAKCYQKGGAFEKEKLALAHDTALSMKSKKVSPKEKQLEYLELAKTYLECKEPTLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCYKDAFRCFEQIQEFDLALKMYCQEELFEEAAIAVEKYEEMLKTKTLPISKLSYSASQFYLEAAAKYLSANKMKEMMAVLSKLDIEDQLVFLKSRKRLAEAADLLNREGRREEAALLMKQHGCLLEAARLTADKDFQASCLLGAARLNVARDSDIEHTKDILREALDICYQTGQLSGIAEAHFLQGVILRDFQKLRDAFFKFDTLNHSAGVVEALYEAASQCEAEPEKILGLAPGGLEILLSLVRALKRVTNNAEKEMVKSCFEFFGISQVDAKYCQIAQNDPGPILRIIFDLDLNLREKKTKDHFLIMTDQVKLALNKHLLGRLCQITRSLLGKTYRGVCMRFIVGLKCEDENCEHFHRPLRRCEAKCLVQSKMNLVAINGLLLEAKKVFPKILAEELKEIDYILSTDMYGLCKSILDVLFPKHFHQRVLSENPMACKEILKPNYKSFRFYRFALKEYIHFLFENESARNRRESTDLWLSAMQAFLLSSNYPEEFEKLLHQEEDNYNRELKALESEKDERGRGRGSRIKGIEGKFGMLAPNRDDENMDKTHLCFIRLLENCIDQFYVYRNPEDYKRLFFRFMNVLIKRCKEPLIPSIGNTVALLEFQFIHCGVVLARLWKNVILCLPKSYIALLHYWEFLFSKKDKELGDVFSIIQEYKPKDVTRAIQDFRFHLSYLAKVLCGYENVNFNVLLDAFSEIDYVVSGEAERTLVLCLVMLVNAEEILQPYCKPLLYRHFREIESRLQLMSMDCPGQVPERLLKVVKRVLVAVNVKSVAEALQDLLFERDEEYLMDCDWRWDPVHTKGSIVRGLYYEEVRLNRLLCLDPVDYFAEPECEFGQDEMDELALEDRDHVLATILSQKQRKASIQRKLRRACLVVSLCISWRRRVGTQMERVREEAREPRAGNFKKADVDRTQCDLCGVKFTRGPENYFSPSKAFEGAASEVAVLSRAELEREECQERNSESYEQHIHLEHHQRQQVAYQKYSEFFHEKVDPAIDEGKLVVQDIEQSVWIHSHVGSKEHSHMLQKVQEHIKRVSDMVEDLYRRKAWAGAEEAMTRLVNILILSVRDARDWLMKTETRLKKEGIVQEDDYENEVEDFGELRPRRRSRKCGKQRKY", "length": 2925, "header": "sp|O15050-1|TRNK1_HUMAN Isoform 1 of TPR and ankyrin repeat-containing protein 1 OS=Homo sapiens OX=9606 GN=TRANK1 PE=2 SV=4 CANONICAL=O15050-1" }, "locus": { "chromosome": "3", "start_pos": 36944809, "end_pos": 36828278, "strand": "+", "evidence": [ { "database": "Ensembl Transcript", "id": "ENST00000429976.5", "url": "https://www.ensembl.org/id/ENST00000429976.5" }, { "database": "Ensembl Peptide", "id": "ENSP00000416168.2", "url": "https://www.ensembl.org/id/ENSP00000416168.2" } ] } } ], "glycosylation": [ { "glytoucan_ac": "G49108TO", "type": "O-linked", "subtype": "O-GlcNAcylation", "site_category": "reported_with_glycan", "site_seq": "", "relation": "attached", "comment": "O-GlcNAcylation", "evidence": [ { "id": "O15050", "database": "O-GlcNAc Database", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15050" }, { "id": "30379171", "database": "PubMed", "url": "https://glygen.org/publication/PubMed/30379171" } ] } ], "phosphorylation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_reported_with_glycan" ], "publication": [ { "title": "Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.", "journal": "Molecular psychiatry", "date": "2013", "authors": "Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ, Kassem L, Park JH, Chatterjee N, Jamain S, Cheng A, Leboyer M, Muglia P, Schulze TG, Cichon S, Nothen MM, Rietschel M, McMahon FJ, Farmer A, McGuffin P, Craig I, Lewis C, Hosang G, Cohen-Woods S, Vincent JB, Kennedy JL, Strauss J", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" } ], "reference": [ { "type": "PubMed", "id": "22182935", "url": "https://glygen.org/publication/PubMed/22182935" } ] }, { "title": "A triarylphosphine-trimethylpiperidine reagent for the one-step derivatization and enrichment of protein post-translational modifications and identification by mass spectrometry.", "journal": "Chemical communications (Cambridge, England)", "date": "2018", "authors": "Huo B, Zhang W, Zhao X, Dong H, Yu Y, Wang J, Qian X, Qin W", "evidence": [ { "database": "O-GlcNAc Database", "id": "O15050", "url": "https://www.oglcnac.mcw.edu/search/?query_protein=O15050" } ], "reference": [ { "type": "PubMed", "id": "30379171", "url": "https://glygen.org/publication/PubMed/30379171" } ] }, { "title": "Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder.", "journal": "Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology", "date": "2021", "authors": "Li W, Cai X, Li HJ, Song M, Zhang CY, Yang Y, Zhang L, Zhao L, Liu W, Wang L, Shao M, Zhang Y, Zhang C, Cai J, Zhou DS, Li X, Hui L, Jia QF, Qu N, Zhong BL, Zhang SF, Chen J, Xia B, Li Y, Song X, Fan W, Tang W, Tang W, Tang J, Chen X, Yue W, Zhang D, Fang Y, Xiao X, Li M, Lv L, Chang H", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" } ], "reference": [ { "type": "PubMed", "id": "32791513", "url": "https://glygen.org/publication/PubMed/32791513" } ] }, { "title": "Kleine-Levin syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "date": "2021", "authors": "Ambati A, Hillary R, Leu-Semenescu S, Ollila HM, Lin L, During EH, Farber N, Rico TJ, Faraco J, Leary E, Goldstein-Piekarski AN, Huang YS, Han F, Sivan Y, Lecendreux M, Dodet P, Honda M, Gadoth N, Nevsimalova S, Pizza F, Kanbayashi T, Peraita-Adrados R, Leschziner GD, Hasan R, Canellas F, Kume K, Daniilidou M, Bourgin P, Rye D, Vicario JL, Hogl B, Hong SC, Plazzi G, Mayer G, Landtblom AM, Dauvilliers Y, Arnulf I, Mignot EJ", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" } ], "reference": [ { "type": "PubMed", "id": "33737391", "url": "https://glygen.org/publication/PubMed/33737391" } ] }, { "title": "Impaired blood-brain barrier in the microbiota-gut-brain axis: Potential role of bipolar susceptibility gene TRANK1.", "journal": "Journal of cellular and molecular medicine", "date": "2021", "authors": "Lai J, Jiang J, Zhang P, Xi C, Wu L, Gao X, Fu Y, Zhang D, Chen Y, Huang H, Zhu Y, Hu S", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" } ], "reference": [ { "type": "PubMed", "id": "34014031", "url": "https://glygen.org/publication/PubMed/34014031" } ] }, { "title": "New Evidence of Gut Microbiota Involvement in the Neuropathogenesis of Bipolar Depression by TRANK1 Modulation: Joint Clinical and Animal Data.", "journal": "Frontiers in immunology", "date": "2021", "authors": "Lai J, Zhang P, Jiang J, Mou T, Li Y, Xi C, Wu L, Gao X, Zhang D, Chen Y, Huang H, Li H, Cai X, Li M, Zheng P, Hu S", "evidence": [ { "database": "RefSeq", "id": "NP_055646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055646" } ], "reference": [ { "type": "PubMed", "id": "34992606", "url": "https://glygen.org/publication/PubMed/34992606" } ] } ], "pathway": [ { "id": "hsa:9881", "name": "", "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:9881", "resource": "KEGG Pathway" } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZSG2-1", "protein_name": "Tetratricopeptide repeat and ankyrin repeat containing 1", "gene_name": "Trank1", "tax_id": 10116, "organism": "Rattus norvegicus", "sequence": { "sequence": "MASRTAGRRWPPRRRSSRRGPTPRSRAPGAKLSAPEAGPPRRGPLPRGGAGRDTLLGAKATPSSPATRRYVTALGPPQPRGNTDSACAALPQPVPHEPREAAFRLVPGSERRASVSPARIPRRRRRVPAMWDPRAARTPPRELAVLLCNKSNAFYSLGKWDEAFLAAKECLQWDPTYVKGYYRAGYSLLHLLQPYEAARMFFEGLRLLQRSPDQVQVPDFLVGIFTTMSSDSIVLQSFLPCFDHIFSTGFSTEVWQSVIQKLAKKGLWHSFLLLSAKKDRLPSNIHVSELSLQSLFEKYVFIGLYEKMEQVPKLVQWLISIGANIETIGPSPLHALMRLCIQSRESQLFRWVMEYKPEWKEHINYRDDAGCTVLHVAAAHFPGYTIKRQTEDVQMLLSFGADPTLLDGHARSAVDVLKRNRNFRAVDKINSHLEKLASSSKGRSEISAGLDVNRDCATTFVKFLLERQKWPEVLLLLTRKASGQHQLRNGLIKDCDLSDLDICTVIPHLSAWDQRKTQLLSRLIDSGALPEGLQDSQDRPLLMCLRHEDFDLAFLLLTKGADPRSVSLMEGDTPLHAALHIFLDINADIGFNFLSHLLDLFLSNPTEFYYLNPNVQDSNGNTLMHLLFQKGMLKRTKKLIELLVKFDINFNLKNKAGKGVRHRIKKNDALLLAWNKALTESRRKNRQDPAAHLGRLSRSSALGHTSQLKSQTSFKSLPCSTADRTLSKGVTEILPDVQVTRQEPEAMRTRSLRDRLVQDITVLIQQIELDMSLPQDYPQQGSPKMAAGMEGKKDKLQRTQSMGSSGSSRDNPVASEAGDGHAQAGPGALQLAPVGNRLRVAGGNQDNWTMQEIQACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHSKGNIQLFEAKLDKGARMLWELAIDFSARCSENSEKIMGTERNTYSMEKSGRVYTEIIRIWDIVLDHCKLSDSIMAICSAYTRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKSIEQADPEYFPPASAVETEYNIMKFHSFSTSMALNILNDMTATVEYPFRVGELEYAVIDLNPKPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLSKQILPKRRLEVEPGKEGPGQEEEENEEEEGSIKVETVDSTEEEQESEACAGGTVESAGDSQAAEGCVPDHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIVGWSTQEEFSIPSWEEDEDEVEADGNYSEEEKTTETQTGDSDPRVYVTFEVFTNEIWPKMIKGRSSYNPALIWKEIKSFLKGSFEALSCPHGRLTEEAYQKLGRKRSPNFKEDRSEIYSLFCLYQQIRSQKGYFDEEDVLYNLSWRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLLSLFHYASRNTVDKQCAVRKPKRIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTLLDSCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEMAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFIPSSDSREENCPLLDVPLEKSSSSQARSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENLEKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPDEWIIQGDYYAKHQCWKVAAKCYQKGDAFEKEKLALAHYTALNMKSKKFSPKEKELQYLELAKTYLECNEPKLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCFKDAFRCFEQIQEFDLALRMYCQEELFEEAAIAVEKYEEMLKNKTFPVPKLSYSASQFYLEAAAKYLSANKSKEMMAVLSKLDVEDQLVFLKSRKRLAEAAELLNREGRKEEAALLMKQHGCLLEAARLTANKDFQASCLLGVARLNVARDSDVEHTKAILREVLDLCYQTGHLAGIAEAQFLQGIILRDFQKLRDAFIKFDMLNHSAGMVEALYEAASQCESESQKVLALAPGGLEVLLNLVRALKNVTNNAEKEMVKSCFEFFGIFQVDAKYCQIAQNDPGPILRIILDLDLTLSEKKTKDHFLVLTDQVKLALNKHLLGRLCQITQILLGKTYPGICMRFIVGLKCEDEHCEDFHRPLRRCEAKCMVQSKMHLVAINGLLLEAKKVFPNVLAEELEEIDYILSPDTYGLCKSFLNLLFPRHFHQRVLSENPMACKEILKANYKFFRSYRFALKEYIHDLFQKESAHSRRESTDLWLSAMQAFLLSSSYPDEFEKLLHQEEDSYNRELKVLESDREDRGRGRGSRMKGIEGKFGMLVPNREDENVERSYLCFIRLLESSMDQLYVHRNPEDYKRLFFRFMNVLIKRCKAPLVPSIINTVVLLELQFVHCGAVLARLWKNAVLCLPKSYIALLHFWEFLSSKKDRESGDVFSIIQEYKPKDVTRAVRDFRFHLSYLVKVLCGYENMNFNVLLDSFSEIDYVISGEAERTLVLCLVMLVNAEEVLHPFCKPLLFRHFREIQKRLQLMSMDWPGQVPKRLQKVVQRVLMAVSVKSVAEALQDLLFERDEEYLVDCHWRWDSVHAKGTVVRGLCHEEVRLNRLLCTGPMDQFADSDWDFGEDETHELDELALEDRDNFLAAILSQKQRKALIQRKLRTACLVVSLCISWRRWIQTEHSREEDRELRPGNFKRADVDRTQCDLCGVKFARSPESYFSAGKAFEGAATEAVIISRAELEGRECRERVSESYEQHIRLEGHRRQQAAYQKYLDFFHEKVDPIIEEGKVVVQDVEQSVWIRSHLGSKEQSHMLQRKVQEHIRKVSDLVEELYRRKAWAEAEEVMTRQVKILTLSVKNAQEWLKKTELRLKDEGTVQDEEYENEVEDFGELCPRRRARKCGKQRKY", "length": 2998 }, "evidence": [ { "id": "45936657", "url": "http://www.informatics.jax.org/homology/45936657", "database": "MGI" } ], "common_name": "Rat" }, { "uniprot_canonical_ac": "Q8BV79-1", "protein_name": "TPR and ankyrin repeat-containing protein 1", "gene_name": "Trank1", "tax_id": 10090, "organism": "Mus musculus", "sequence": { "sequence": "MASTTAGRRWPPRRRSSRRGPTPRSRAPGAKLSAPEAGPPRRGPLPRGGAGRDTLLGAKATPSSPAARRYVTALGPPQPRGSTDSACAALPQPVPHEPREAAFRLAPASERGASVSPARIPRRRRRVPAMWDPRAARTPPRELAMLLCNKSNAFYNLGKWNEAFLAAKECLQWDPTYVKGYYRAGYSLLHLLQPYEAARMFFEGLRLLQRSPDQLQVPDFLVGIFTTMSSDSIVLQSFLPCFDHIFTTGFSTEVWQYVIQKLAKKGLWHSFLLLSAKKDRLPSNIHVSELSLQSLFEKYVFIGFYEKLEQVPKLVQWLVSIGANIETIGPNPLHALMRLCIQARESQLFRWVMDQKPEWKEHINHRDDAGCTVLHVAAAHFPGYTSRRQTEDVQMLLSFGADPTLLDGHARTVVDVLKRNKNFRAIDKINSHLEKLASSSKGLSEIPAGLVCDVNRDCATTFIKFLLERQKWPEVLLLLTRKVSGQPQLRNGVIKDCDLSDLDICTVIPHLSSWDQRKTQLLSRLIDSGALPEGLQDSQDRPLLMCLRHEDFDLAFLLLTKGADPRSVSLVEGDTPLHAALHIFLDINADIGFNFLSHLLDLFLSNPTEFYYLNPNVQDSNGNTLMHLLFQKGMLKRTKKLIDLLVKFDINFNLKNKAGKGVRHRIKKNDALLLAWNKALTESRRKNRQDPAAHLGRLSRSSAPGHTSQLKSQTSFKSLPCGTADTTLSKGLTESLPDVQVSRQEPEAVRTRSLRDRLVQDITVLIQQVELGMPLPEDSPQRDSPKVAAGTEGKKDKLQRTQRMGSSGCSGNNPVASEAGDGAQAGPGASQLVPVGNRLGVASDNQENWTMQEIQACLQDFDNMTWEIECTSEMLKKLSSKVMTKVIKKKIILAIQQLGNGEWTQGLQKRLKHSKGNIQLFEAKLDKGARMLWELAIDFSARCSENSEKIIGTERNTYSLEKSGRVYTEIIRIWDIVLDHCKLSDSIMAICSAYTRGLSCVLRKKLKGINKGQVSANMKIQKRIPRCYVEDTEAEKSLEQVDPEYFPPASAVETEYSIMKFHSFSTNMALNILNDMTATVEYPFRVGELEYAVIDLNPKPLEPIILIGRSGTGKTTCCLYRLWKKFHVYWEKAEQAGSPLLSKQILPKRRLEVEPGKEGPGREEEEHEEEEGSIKVETVDGIDEEQESEACAGGATVEPAGDSQGAEGCVPDHPHQLEHLHQIFVTKNHVLCQEVQRNFIELSKSTKATSHYKPLDPNVHKLQDLRDENFPLFVTSKQLLLLLDASLPKPFFLRNEDGSLKRTIVGWSTQEEFSIPSWEEDDEEVEADGNYNEEEKATETQTGDSDPRVYVTFEVFTNEIWPKMIKGRSSYNPALIWKEIKSFLKGSFEALSCPHGRLTEEAYKKLGRKRSPNFKEDRSEIYSLFCLYQQIRSQKGYFDEEDVLYNLSWRLSKLRVLPWSIHELYGDEIQDFTQAELALLMKCINDPNAMFLTGDTAQSIMKGVAFRFSDLLSLFHYASRSTVDKQCAVRKPKRIHQLYQNYRSHSGILNLASGVVDLLQFYFPESFDRLPRDSGLFDGPKPTLLDSCSVSDLAILLRGNKRKTQPIEFGAHQVILVANEKAKEKIPEELGLALVLTVYEAKGLEFDDVLLYNFFTDSEAYKEWKIISSFTPSSDSREEKWPLVDVPLERSSPSQARSLMVNPEMYKLLNGELKQLYTAITRARVNLWIFDENLEKRAPAFKYFIRRDFVQVVKTDENKDFDDSMFVKTSTPYEWIIQGDYYAKHQCWKVAAKCYQKGDALEKEKLALAHYTALNMKSKKFSPKEKELQYLELAKTYLECNEPKLSLKCLSYAKEFQLSAQLCERLGKIRDAAYFYKRSQCFQDAFRCFEQIQEFDLALRMYCQEELFEEAAIAVEKYEEMLKNKTFPIPKLSYSASQFYLEAAAKYLSANKSKEMMAVLSKLDVEDQLVFLKSRKCLAEAAELLNREGRREEAALLMKQHGCLLEAARLTANKDFQASCLLGVARFNVARDSDIEHTKVILREALDLCYQTSQLAGIAEAQFLLGIILRDFQKLRDAFIKFDMLNHSAGMVEALYEAASLCESEHQKVLALAPGGLEVLLNLVRALKNVTNNAEKEMVKSCFEFFGIFQVDAKYCQIAQNDPGPILRIILDLDLTLSEKKTKDHFLIVTDQVKLALNKHLLGRLCQITQILLGKAYPGICMRFIVGLKCEDEQCEDFHRPLRRCEAKCMVQSKMHLVAINGLLLEAKKVFPNVLAEDLEEMDYILSPDTYGLCKSFLNLLFPRHFHQRVLSENPMACKDILKPNYKSFRSFRCALKEYIHDLFQKESAHSRRESTDLWLSAMQAFLLSSSYPEDFEKLLRQEEDSYNRELKVLESDREDRGRGRGSRVRGIEGKFGMLVPNREDENVEKSYLCFIRLLESSMDQLYVRRNPGDYKRLFFRFMNVLIKRCKAPLVPSIINTVVLLELQFVHCGVVLTRLWKNAVLCLPKSYIALLHFWEFLYGKKDRESGEVFSIIQEYKPKDVTRAIRDFRFHLSYLVKVLCGYENMNFNVLLDSFSEIDYVISGEAERTLVLCLVMLVNAEEVLQPFCKPLLFRHFREIQTRLQLMSMDWPGQVPKRLLKVVQRVLVAASVKSVAEALQDLLFERDEEYLVDCHWRWDSVHTKGTVVRGLCHEEVRLNRLLCTGPMDQFADSEWDFGEDETHELDELAQEDRDNFLAAILSQKQRKALIQRKLRRVCLVVSLCIRWRRWVQTEHSREDREVRPGNFKRADVDRTQCDLCGVKFTRSPESYFSPGKAFEGTATEAVLISRAELEGRECRERISESYEQHIRLEGHRRQQAAYQKYLDFFHEKVDPIIEEGKVVVQGIEQSVWIRSHLGSKEQSHMLQRKVQEHIRRVSDLVEELYRRKAWAEAEEVMTQQVKILTLSVKNAQEWLKKTELRLKDEGTVQEEEYENEVEDFGELRPRRRAQKCGKQRKH", "length": 2999 }, "evidence": [ { "id": "45936657", "url": "http://www.informatics.jax.org/homology/45936657", "database": "MGI" } ], "common_name": "Mouse" } ], "go_annotation": { "categories": [ { "name": "Molecular Function", "total": 3, "go_terms": [ { "name": "ATP binding", "id": "GO:0005524", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005524", "evidence": [ { "database": "UniProtKB", "id": "O15050", "url": "https://www.uniprot.org/uniprot/O15050" } ], "pmid": "" }, { "name": "hydrolase activity", "id": "GO:0016787", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016787", "evidence": [ { "database": "UniProtKB", "id": "O15050", "url": "https://www.uniprot.org/uniprot/O15050" } ], "pmid": "" }, { "name": "helicase activity", "id": "GO:0004386", "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004386", "evidence": [ { "database": "UniProtKB", "id": "O15050", "url": "https://www.uniprot.org/uniprot/O15050" } ], "pmid": "" } ] } ] }, "pro_annotation": [], "site_annotation": [ { "start_pos": 1372, "end_pos": 1374, "annotation": "n_glycosylation_sequon" }, { "start_pos": 1545, "end_pos": 1547, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2013, "end_pos": 2015, "annotation": "n_glycosylation_sequon" }, { "start_pos": 20, "end_pos": 22, "annotation": "n_glycosylation_sequon" }, { "start_pos": 2273, "end_pos": 2275, "annotation": "n_glycosylation_sequon" }, { "start_pos": 423, "end_pos": 425, "annotation": "n_glycosylation_sequon" }, { "start_pos": 594, "end_pos": 596, "annotation": "n_glycosylation_sequon" }, { "start_pos": 787, "end_pos": 789, "annotation": "n_glycosylation_sequon" }, { "start_pos": 998, "end_pos": 1000, "annotation": "n_glycosylation_sequon" } ], "ptm_annotation": [], "interactions": [], "reactions": [], "reaction_participants": [], "reaction_enzymes": [], "biomarkers": [], "synthesized_glycans": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "sequence_features": { "n_linked_sites": [], "o_linked_sites": [], "snv_sites": [ 2617, 2816 ], "glycation_sites": [], "phosphorylation_sites": [], "sequon_annotation_sites": [ { "start_pos": 1372, "end_pos": 1374 }, { "start_pos": 1545, "end_pos": 1547 }, { "start_pos": 2013, "end_pos": 2015 }, { "start_pos": 20, "end_pos": 22 }, { "start_pos": 2273, "end_pos": 2275 }, { "start_pos": 423, "end_pos": 425 }, { "start_pos": 594, "end_pos": 596 }, { "start_pos": 787, "end_pos": 789 }, { "start_pos": 998, "end_pos": 1000 } ] }, "section_stats": [ { "table_id": "glycosylation", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_reported", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_reported_with_glycan", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 1 }, { "field": "o_linked_glycan_sites", "count": 1 } ], "sort_fields": [ "glytoucan_ac", "type", "subtype", "site_category", "site_seq", "relation", "comment" ] }, { "table_id": "glycosylation_predicted", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "glycosylation_automatic_literature_mining", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 }, { "field": "n_linked_glycans", "count": 0 }, { "field": "n_linked_glycan_sites", "count": 0 }, { "field": "o_linked_glycans", "count": 0 }, { "field": "o_linked_glycan_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "phosphorylation", "table_stats": [ { "field": "total", "count": 0 }, { "field": "total_sites", "count": 0 } ], "sort_fields": [] }, { "table_id": "snv", "table_stats": [ { "field": "total", "count": 2 }, { "field": "total_sites", "count": 2 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "snv_non_disease", "table_stats": [ { "field": "total", "count": 1 }, { "field": "total_sites", "count": 1 } ], "sort_fields": [ "start_pos", "end_pos", "subjects_tested", "subjects_positive", "frequency", "sequence_org", "sequence_mut", "comment", "chr_id", "chr_pos", "ref_nt", "alt_nt", "minor_allelic_frequency", "site_lbl" ] }, { "table_id": "publication", "table_stats": [ { "field": "total", "count": 6 } ], "sort_fields": [ "title", "journal", "date", "authors" ] } ] }